presynaptic terminals

Summary

Summary: The distal terminations of axons which are specialized for the release of neurotransmitters. Also included are varicosities along the course of axons which have similar specializations and also release transmitters. Presynaptic terminals in both the central and peripheral nervous systems are included.

Top Publications

  1. ncbi A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization
    Qi Li
    Cellular and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8 Canada
    J Neurosci 24:4070-81. 2004
  2. ncbi Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    Dhananjay A Wagh
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Am Hubland, D 97074 Wurzburg, Germany
    Neuron 49:833-44. 2006
  3. pmc RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
    Pascal S Kaeser
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5453, USA
    Cell 144:282-95. 2011
  4. ncbi Presynaptic inhibition in the vertebrate spinal cord revisited
    P Rudomin
    Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Apartado Postal 14 740, Mexico DF 07000, Mexico
    Exp Brain Res 129:1-37. 1999
  5. pmc Release probability of hippocampal glutamatergic terminals scales with the size of the active zone
    Noémi Holderith
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Nat Neurosci 15:988-97. 2012
  6. ncbi Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
    Robert J Kittel
    European Neuroscience Institute Göttingen, Grisebachstrasse 5, 37077 Gottingen, Germany
    Science 312:1051-4. 2006
  7. pmc Examining size-strength relationships at hippocampal synapses using an ultrastructural measurement of synaptic release probability
    Tiago Branco
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK
    J Struct Biol 172:203-10. 2010
  8. pmc RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
    Yunyun Han
    Laboratory of Synaptic Mechanisms, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Neuron 69:304-16. 2011
  9. pmc Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
    Shernaz X Bamji
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:719-31. 2003
  10. pmc Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
    Azlina Ahmad-Annuar
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 174:127-39. 2006

Detail Information

Publications326 found, 100 shown here

  1. ncbi A syntaxin 1, Galpha(o), and N-type calcium channel complex at a presynaptic nerve terminal: analysis by quantitative immunocolocalization
    Qi Li
    Cellular and Molecular Biology Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, M5T 2S8 Canada
    J Neurosci 24:4070-81. 2004
    ..2 and Galpha(O), as well as in large clusters remote from the release site with MUNC18-1. These syntaxin 1 protein complexes may play distinct roles in presynaptic biology...
  2. ncbi Bruchpilot, a protein with homology to ELKS/CAST, is required for structural integrity and function of synaptic active zones in Drosophila
    Dhananjay A Wagh
    Lehrstuhl für Genetik und Neurobiologie, Theodor Boveri Institut für Biowissenschaften, Am Hubland, D 97074 Wurzburg, Germany
    Neuron 49:833-44. 2006
    ..We propose that BRP is critical for intact AZ structure and normal-evoked neurotransmitter release at chemical synapses of Drosophila...
  3. pmc RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
    Pascal S Kaeser
    Department of Molecular and Cellular Physiology, Stanford University, Stanford, CA 94305 5453, USA
    Cell 144:282-95. 2011
    ..We propose that RIMs tether N- and P/Q-type Ca(2+) channels to presynaptic active zones via a direct PDZ-domain-mediated interaction, thereby enabling fast, synchronous triggering of neurotransmitter release at a synapse...
  4. ncbi Presynaptic inhibition in the vertebrate spinal cord revisited
    P Rudomin
    Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Apartado Postal 14 740, Mexico DF 07000, Mexico
    Exp Brain Res 129:1-37. 1999
    ..This central control of information flow in peripheral afferents appears to play an important role in the generation of integrated movements and processing of sensory information, including nociceptive information...
  5. pmc Release probability of hippocampal glutamatergic terminals scales with the size of the active zone
    Noémi Holderith
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary
    Nat Neurosci 15:988-97. 2012
    ..Our results demonstrate that the numbers of several active-zone proteins, including presynaptic calcium channels, as well as the number of docked vesicles and the release probability, scale linearly with the active-zone area...
  6. ncbi Bruchpilot promotes active zone assembly, Ca2+ channel clustering, and vesicle release
    Robert J Kittel
    European Neuroscience Institute Göttingen, Grisebachstrasse 5, 37077 Gottingen, Germany
    Science 312:1051-4. 2006
    ..BRP-like proteins seem to establish proximity between Ca2+ channels and vesicles to allow efficient transmitter release and patterned synaptic plasticity...
  7. pmc Examining size-strength relationships at hippocampal synapses using an ultrastructural measurement of synaptic release probability
    Tiago Branco
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK
    J Struct Biol 172:203-10. 2010
    ..The lack of a direct correlation between total synaptic size and performance in these terminals suggests that factors other than the absolute magnitude of the synapse are the most important determinants of synaptic efficacy...
  8. pmc RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone
    Yunyun Han
    Laboratory of Synaptic Mechanisms, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, 1015 Lausanne, Switzerland
    Neuron 69:304-16. 2011
    ..Thus, RIM proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca²+ channel density and vesicle docking at the active zone...
  9. pmc Role of beta-catenin in synaptic vesicle localization and presynaptic assembly
    Shernaz X Bamji
    Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 40:719-31. 2003
    ..This study defines a specific role for cadherins and catenins in synapse organization beyond their roles in mediating cell adhesion...
  10. pmc Signaling across the synapse: a role for Wnt and Dishevelled in presynaptic assembly and neurotransmitter release
    Azlina Ahmad-Annuar
    Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, England, UK
    J Cell Biol 174:127-39. 2006
    ..These findings demonstrate that Wnts signal across the synapse on Dvl-expressing presynaptic terminals to regulate synaptic assembly and suggest a potential novel function for Wnts in neurotransmitter release.
  11. ncbi The synaptic vesicle cycle
    Thomas C Sudhof
    Center for Basic Neuroscience, Department of Molecular Genetics, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA Thomas
    Annu Rev Neurosci 27:509-47. 2004
    ..The present review attempts to relate these molecular data with physiological results in an emerging view of nerve terminals as macromolecular machines...
  12. ncbi Inhibitory synapse dynamics: coordinated presynaptic and postsynaptic mobility and the major contribution of recycled vesicles to new synapse formation
    Frederick A Dobie
    Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Neurosci 31:10481-93. 2011
    ..Altogether, the long-term imaging of GABAergic presynaptic and postsynaptic components reveals complex dynamics and perpetual remodeling with implications for mechanisms of assembly and synaptic integration...
  13. pmc A vesicle superpool spans multiple presynaptic terminals in hippocampal neurons
    Kevin Staras
    School of Life Sciences, University of Sussex, Brighton, UK
    Neuron 66:37-44. 2010
    ....
  14. ncbi Calcium channel regulation and presynaptic plasticity
    William A Catterall
    Department of Pharmacology, University of Washington, Seattle, WA 98195 7280, USA
    Neuron 59:882-901. 2008
    ..We propose that presynaptic Ca(2+) channels serve as the regulatory node in a dynamic, multilayered signaling network that exerts short-term control of neurotransmission in response to synaptic activity...
  15. ncbi Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development
    Katsunori Nakata
    Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California 95064, USA
    Cell 120:407-20. 2005
    ..DLK-1 protein levels are elevated in rpm-1 mutants. The RPM-1 RING finger can stimulate ubiquitination of DLK-1. Our data reveal a presynaptic role of a previously unknown p38 MAP kinase cascade...
  16. ncbi Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo
    John R Cirrito
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 48:913-22. 2005
    ..The findings also have important implications for treatment development...
  17. pmc A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction
    Jan Pielage
    Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, USA
    J Cell Biol 175:491-503. 2006
    ..We propose a model in which a postsynaptic Spectrin-actin lattice acts as an organizing scaffold upon which pre- and postsynaptic development are arranged...
  18. ncbi Presynaptic glutamate receptors: physiological functions and mechanisms of action
    Paulo S Pinheiro
    Laboratoire Physiologie Cellulaire de la Synapse, Centre National de la Recherche Scientifique Unite mixte de recherche 5091, Bordeaux Neuroscience Institute, University of Bordeaux, 33077 Bordeaux, France
    Nat Rev Neurosci 9:423-36. 2008
    ..Furthermore, we discuss the physiological conditions that are necessary for their activation, the source of the glutamate that activates them, their mechanisms of action and their involvement in higher brain function...
  19. pmc LRP4 serves as a coreceptor of agrin
    Bin Zhang
    Program of Developmental Neurobiology, Institute of Molecular Medicine and Genetics, Department of Neurology, Medical College of Georgia, Augusta, GA 30912, USA
    Neuron 60:285-97. 2008
    ..These observations indicate that LRP4 is a coreceptor of agrin that is necessary for MuSK signaling and AChR clustering and identify a potential target protein whose mutation and/or autoimmunization may cause muscular dystrophies...
  20. pmc An unbiased expression screen for synaptogenic proteins identifies the LRRTM protein family as synaptic organizers
    Michael W Linhoff
    The Brain Research Centre and Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
    Neuron 61:734-49. 2009
    ..These results suggest a prevalence of LRR domain proteins in trans-synaptic signaling and provide a cellular basis for the reported linkage of LRRTM1 to handedness and schizophrenia...
  21. pmc Quantal analysis reveals a functional correlation between presynaptic and postsynaptic efficacy in excitatory connections from rat neocortex
    Neil R Hardingham
    The University Laboratory of Physiology, Oxford University, Oxford, OX1 3PT, United Kingdom
    J Neurosci 30:1441-51. 2010
    ..The efficacy of a cortical connection is thus set by coordinated presynaptic and postsynaptic strength...
  22. ncbi The synaptic vesicle protein CSP alpha prevents presynaptic degeneration
    Rafael Fernandez-Chacon
    Center for Basic Neuroscience, Department of Molecular Genetics and Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Neuron 42:237-51. 2004
    ....
  23. pmc Dynamin I phosphorylation by GSK3 controls activity-dependent bulk endocytosis of synaptic vesicles
    Emma L Clayton
    Centre for Integrative Physiology, George Square, University of Edinburgh, Edinburgh, Scotland, UK
    Nat Neurosci 13:845-51. 2010
    ..These results demonstrate a presynaptic role for GSK3 and they indicate that a protein kinase signaling cascade prepares synaptic vesicles for retrieval during elevated neuronal activity...
  24. ncbi A selective activity-dependent requirement for dynamin 1 in synaptic vesicle endocytosis
    Shawn M Ferguson
    Howard Hughes Medical Institute, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 316:570-4. 2007
    ..Thus, dynamin 1-independent mechanisms can support limited synaptic vesicle endocytosis, but dynamin 1 is needed during high levels of neuronal activity...
  25. ncbi Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential
    Yousheng Shu
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 441:761-5. 2006
    ....
  26. ncbi RIM-binding protein, a central part of the active zone, is essential for neurotransmitter release
    Karen S Y Liu
    Department of Genetics, Institute for Biology, Free University Berlin, 14195 Berlin, Germany
    Science 334:1565-9. 2011
    ..Our data identify RBP family proteins as prime effectors of the AZ scaffold that are essential for the coupling of SVs, Ca(2+) channels, and the SV fusion machinery...
  27. pmc α2δ expression sets presynaptic calcium channel abundance and release probability
    Michael B Hoppa
    Department of Biochemistry, Weill Cornell Medical College, New York, New York 10023, USA
    Nature 486:122-5. 2012
    ..Our data reveal dual functionality of these clinically important VGCC subunits, allowing synapses to make more efficient use of Ca(2+) entry to drive neurotransmitter release...
  28. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
    ..The map of the whole cortical circuit shows that there are very few "strong" but many "weak" excitatory projections, each of which may involve only a few percentage of the total complement of excitatory synapses of a single neuron...
  29. pmc A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
    Jianyuan Sun
    Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nature 450:676-82. 2007
    ..We propose a dual-Ca2+-sensor model of release that quantitatively describes the contributions of synchronous and asynchronous release under conditions of different presynaptic Ca2+ dynamics...
  30. ncbi Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling
    Susan M Voglmaier
    Department of Neurology, Graduate Programs in Cell Biology, Neuroscience and Biomedical Sciences, UCSF School of Medicine, 600 16th Street, San Francisco, California 94143, USA
    Neuron 51:71-84. 2006
    ..After stimulation, however, inhibition of the AP3 pathway prevents the full recovery of VGLUT1 by endocytosis, implicating the AP3 pathway specifically in compensatory endocytosis...
  31. pmc Rapid activity-dependent modifications in synaptic structure and function require bidirectional Wnt signaling
    Bulent Ataman
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Neuron 57:705-18. 2008
    ..We propose that activation of the postsynaptic Wg pathway is required for the assembly of the postsynaptic apparatus, while activation of the presynaptic Wg pathway regulates cytoskeletal dynamics...
  32. ncbi Molecular dynamics of a presynaptic active zone protein studied in Munc13-1-enhanced yellow fluorescent protein knock-in mutant mice
    Stefan Kalla
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Neurosci 26:13054-66. 2006
    ..They demonstrate the usefulness of the knock-in approach in general and of Munc13-1-EYFP knock-in mice in particular for imaging synaptic protein dynamics...
  33. ncbi Cadherin regulates dendritic spine morphogenesis
    Hideru Togashi
    Department of Cell and Developmental Biology, Graduate School of Biostudies, Kyoto University, Kitashirakawa, Sakyo ku, Japan
    Neuron 35:77-89. 2002
    ..These findings suggest that cadherin regulates dendritic spine morphogenesis and related synaptic functions, presumably cooperating with cadherin-independent adhesive mechanisms to maintain spine-axon contacts...
  34. pmc Bassoon, a novel zinc-finger CAG/glutamine-repeat protein selectively localized at the active zone of presynaptic nerve terminals
    S tom Dieck
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Cell Biol 142:499-509. 1998
    ..These data indicate that Bassoon is a strong candidate to be involved in cytomatrix organization at the site of neurotransmitter release...
  35. ncbi The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn
    A J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Eur J Neurosci 17:13-27. 2003
    ..As all primary afferents are thought to be glutamatergic, this raises the possibility that unmyelinated afferents, most of which are nociceptors, express a different vesicular glutamate transporter...
  36. ncbi New roles for astrocytes: regulation of synaptic transmission
    Eric A Newman
    Department of Neuroscience, University of Minnesota, 6 145 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA
    Trends Neurosci 26:536-42. 2003
    ..Based on these new findings, glia should be considered an active partner at the synapse, dynamically regulating synaptic transmission...
  37. ncbi Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    A Abeliovich
    Department of Neurology, University of California, San Francisco 94143, USA
    Neuron 25:239-52. 2000
    ..These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission...
  38. pmc The Alzheimer's β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
    Patty C Kandalepas
    Department of Cell and Molecular Biology, The Feinberg School of Medicine, Northwestern University, 300 East Superior Street, Tarry 8 713, Chicago, IL 60611 3006, USA
    Acta Neuropathol 126:329-52. 2013
    ..In addition, BACE1 accumulated in swollen dystrophic autophagosome-poor presynaptic terminals surrounding amyloid plaques in 5XFAD cortex and hippocampus...
  39. ncbi The existence of a second vesicular glutamate transporter specifies subpopulations of glutamatergic neurons
    E Herzog
    , , , France
    J Neurosci 21:RC181. 2001
    ..At the protein level, we could only detect either VGLUT1- or VGLUT2-expressing presynaptic boutons. The existence of two VGLUTs thus defines distinct subsets of glutamatergic neurons...
  40. ncbi Regulation of presynaptic terminal organization by C. elegans RPM-1, a putative guanine nucleotide exchanger with a RING-H2 finger domain
    M Zhen
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064, USA
    Neuron 26:331-43. 2000
    b>Presynaptic terminals contain highly organized subcellular structures to facilitate neurotransmitter release. In C. elegans, the typical presynaptic terminal has an electron-dense active zone surrounded by synaptic vesicles...
  41. pmc RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13
    Lunbin Deng
    Department of Molecular and Cellular Physiology, Stanford University, Lorry Lokey Building, 265 Campus Drive, Stanford, CA 94305 5453, USA
    Neuron 69:317-31. 2011
    ..Both mutant and wild-type Munc13, however, rescued priming in Munc13-deficient synapses. Thus, homodimerization of Munc13 inhibits its priming function, and RIMs activate priming by disrupting Munc13 homodimerization...
  42. ncbi Cooperation of Syd-1 with Neurexin synchronizes pre- with postsynaptic assembly
    David Owald
    Freie Universitat Berlin, Institute for Biology Genetics, Berlin, Germany
    Nat Neurosci 15:1219-26. 2012
    ..Thus, cooperation between Syd-1 and Nrx-1-Nlg1 seems to orchestrate early assembly processes between pre- and postsynaptic membranes, promoting avidity of newly forming synaptic scaffolds...
  43. pmc Distinct FGFs promote differentiation of excitatory and inhibitory synapses
    Akiko Terauchi
    Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 2200, USA
    Nature 465:783-7. 2010
    ..growth factor (FGF) family, FGF22 and FGF7, promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers...
  44. pmc Neurexin mediates the assembly of presynaptic terminals
    Camin Dean
    Department of Molecular and Cell Biology, University of California, Berkeley, 271 LSA, California 94720, USA
    Nat Neurosci 6:708-16. 2003
    ..In response to this clustering, neurexins nucleate the assembly of a cytoplasmic scaffold to which the exocytotic apparatus is recruited...
  45. ncbi Neuronal P2X7 receptors are targeted to presynaptic terminals in the central and peripheral nervous systems
    S A Deuchars
    School of Biomedical Sciences, University of Leeds, LS2 9NQ, Leeds, United Kingdom
    J Neurosci 21:7143-52. 2001
    ..P2X(7) receptor protein with immunohistochemistry and electron microscopy revealed that it is targeted to presynaptic terminals in the CNS...
  46. pmc Rab3 dynamically controls protein composition at active zones
    Ethan R Graf
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Neuron 64:663-77. 2009
    ..While previous studies of Rab3 have focused on its role in the synaptic vesicle cycle, these findings demonstrate an additional and unexpected function for Rab3 in the localization of presynaptic proteins to active zones...
  47. pmc Target-specific expression of presynaptic NMDA receptors in neocortical microcircuits
    Katherine A Buchanan
    Department of Neuroscience, Physiology, and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Neuron 75:451-66. 2012
    ..We conclude that postsynaptic cell type determines presynaptic terminal molecular identity and that preNMDARs govern information processing in neocortical columns...
  48. pmc A specific role for Ca2+-dependent adenylyl cyclases in recovery from adaptive presynaptic silencing
    Krista L Moulder
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 28:5159-68. 2008
    ....
  49. pmc Local presynaptic activity gates homeostatic changes in presynaptic function driven by dendritic BDNF synthesis
    Sonya K Jakawich
    Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA
    Neuron 68:1143-58. 2010
    ..and that the induction of presynaptic, but not postsynaptic, changes requires coincident local activity in presynaptic terminals. This "state-dependent" modulation of presynaptic function requires postsynaptic release of brain-derived ..
  50. pmc Presynaptic NMDA receptors: newly appreciated roles in cortical synaptic function and plasticity
    Rebekah Corlew
    Curriculum in Neurobiology, Neuroscience Center, University of North Carolina, Chapel Hill, NC 27599 7545, USA
    Neuroscientist 14:609-25. 2008
    ..They discuss the prevalence, function, and development of these receptors, and their potential modification by experience and in brain pathology...
  51. ncbi The presynaptic particle web: ultrastructure, composition, dissolution, and reconstitution
    G R Phillips
    The Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology and The Fishberg Research Center for Neurobiology, New York, NY 10029, USA
    Neuron 32:63-77. 2001
    ..The CNS synaptic junction may therefore be conceptualized as a complicated macromolecular scaffold that isostatically bridges two closely aligned plasma membranes...
  52. pmc Presynaptic local signaling by a canonical wingless pathway regulates development of the Drosophila neuromuscular junction
    Claudia Miech
    F M Kirby Neurobiology Center, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 28:10875-84. 2008
    ....
  53. ncbi M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals
    Maria Martire
    Institute of Pharmacology, School of Medicine, Catholic University of Sacred Heart, 00168 Rome, Italy
    J Neurosci 24:592-7. 2004
    ..These findings provide novel evidence for a major regulatory role of KCNQ2 K+ channel subunits in neurotransmitter release from rat hippocampal nerve endings...
  54. pmc Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals
    Marco Feligioni
    Department of Anatomy, MRC Centre for Synaptic Plasticity, School of Medical Sciences, University of Bristol, Bristol, UK
    Eur J Neurosci 29:1348-56. 2009
    ..These results demonstrate that, in addition to postsynaptic effects, protein SUMOylation acts to modulate neurotransmitter release and thereby regulate synaptic function...
  55. ncbi Quantitative comparison of glutamatergic and GABAergic synaptic vesicles unveils selectivity for few proteins including MAL2, a novel synaptic vesicle protein
    Mads Grønborg
    Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    J Neurosci 30:2-12. 2010
    ....
  56. ncbi Vesicle pools and short-term synaptic depression: lessons from a large synapse
    Ralf Schneggenburger
    Max Planck Institut fur biophysikalische Chemie, Abteilung Membranbiophysik, Am Fassberg, D 37077 Gottingen, Germany
    Trends Neurosci 25:206-12. 2002
    ..By influencing the synaptic output during repetitive activity, vesicle pool dynamics are expected to modulate information processing in neuronal networks of the CNS...
  57. ncbi Bulk membrane retrieval in the synaptic terminal of retinal bipolar cells
    Matthew Holt
    Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 2QH, United Kingdom
    J Neurosci 23:1329-39. 2003
    ..Bulk retrieval did not play an essential role in maintaining the vesicle cycle during maintained stimulation, but we suggest that it may play a role in the structural plasticity of this synaptic terminal...
  58. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children s Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
    ..recordings of striatal dopamine release to directly measure effects of dopamine at the level of individual presynaptic terminals. Dopamine released by either electrical stimulation or amphetamine acted via D2 receptors to inhibit the ..
  59. ncbi Synaptic theory of working memory
    Gianluigi Mongillo
    Group for Neural Theory, Departement d Etudes Cognitives, Ecole Normale Supérieure et Collège de France, Paris, France
    Science 319:1543-6. 2008
    ..The duration and stability of working memory can be regulated by modulating the spontaneous activity in the network...
  60. ncbi Light evokes Ca2+ spikes in the axon terminal of a retinal bipolar cell
    D A Protti
    Max Planck Institute for Biophysical Chemistry, Gottingen, Germany
    Neuron 25:215-27. 2000
    ..Signaling via spikes in a specific class of bipolar cells may serve to accelerate and amplify small photo-receptor signals, thereby securing the synaptic transmission of dim and rapidly changing visual input...
  61. ncbi SYD-2 Liprin-alpha organizes presynaptic active zone formation through ELKS
    Ya Dai
    Department of Molecular, Cell and Developmental Biology, Sinsheimer Laboratories, University of California, 1156 High Street, Santa Cruz, California 95064, USA
    Nat Neurosci 9:1479-87. 2006
    ..The mutant SYD-2 shows increased association with ELKS. These results establish a functional dependency for assembly of the presynaptic active zone in which SYD-2 plays a key role...
  62. pmc Beta-secretase-1 elevation in transgenic mouse models of Alzheimer's disease is associated with synaptic/axonal pathology and amyloidogenesis: implications for neuritic plaque development
    Xue Mei Zhang
    Department of Anatomy, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA
    Eur J Neurosci 30:2271-83. 2009
    ..Prior to plaque onset, localized BACE1/Abeta IR occurred at swollen presynaptic terminals and fine axonal processes...
  63. ncbi Development of the vertebrate neuromuscular junction
    J R Sanes
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 22:389-442. 1999
    ..Finally, we consider the extent to which the NMJ is a suitable model for development of neuron-neuron synapses...
  64. ncbi RIM1alpha forms a protein scaffold for regulating neurotransmitter release at the active zone
    Susanne Schoch
    The Center for Basic Neuroscience and Department of Molecular Genetics, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9111, USA
    Nature 415:321-6. 2002
    ..These data indicate that RIM1alpha has a central function in integrating active zone proteins and synaptic vesicles into a molecular scaffold that controls neurotransmitter release...
  65. ncbi Diversification of synaptic strength: presynaptic elements
    Harold L Atwood
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    Nat Rev Neurosci 3:497-516. 2002
    ..Closing the gap between molecular and physiological synaptic diversification still represents a considerable challenge...
  66. ncbi Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses
    Pablo García-Junco-Clemente
    Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío Consejo Superior de Investigaciones Cientificas, Universidad de Sevilla, Sevilla, Spain
    J Neurosci 30:7377-91. 2010
    ..These findings demonstrate that elevated neural activity increases synapse vulnerability and that CSP-alpha is essential to maintain presynaptic function under a physiologically high-activity regimen...
  67. ncbi Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
    Fabian Feiguin
    International Centre for Genetic Engineering and Biotechnology, Padriciano 99, Trieste, Italy
    FEBS Lett 583:1586-92. 2009
    ..Our results demonstrate the role of this protein in vivo and suggest an alternative explanation to ALS pathogenesis that may be more due to the lack of TDP 43 function than to the toxicity of the aggregates...
  68. pmc The molecular architecture of ribbon presynaptic terminals
    George Zanazzi
    Department of Neurobiology and Behavior, State Universtiy of New York, Stony Brook, NY 11794 5230, USA
    Mol Neurobiol 39:130-48. 2009
    ..Consistent with its functional importance, abnormalities in a variety of functional aspects of the ribbon presynaptic terminal underlie several forms of auditory neuropathy and retinopathy...
  69. ncbi Presynaptic NMDARs in the hippocampus facilitate transmitter release at theta frequency
    Lindsay McGuinness
    Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, UK
    Neuron 68:1109-27. 2010
    ..We use this novel estimator to show that p(r) increases following the induction of long-term potentiation...
  70. ncbi Molecular determinants of synapsin targeting to presynaptic terminals
    Daniel Gitler
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 24:3711-20. 2004
    Although synapsins are abundant synaptic vesicle proteins that are widely used as markers of presynaptic terminals, the mechanisms that target synapsins to presynaptic terminals have not been elucidated...
  71. ncbi The immunoglobulin superfamily protein SYG-1 determines the location of specific synapses in C. elegans
    Kang Shen
    Department of Anatomy, Howard Hughes Medical Institute, Box 0452, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 112:619-30. 2003
    ..SYG-1 is related to Drosophila IrreC and vertebrate NEPH1 proteins, which mediate cell-cell recognition in diverse developmental contexts...
  72. ncbi Activity-dependent regulation of synaptic vesicle exocytosis and presynaptic short-term plasticity
    Sumiko Mochida
    Department of Physiology, Tokyo Medical University, 1 1, Shinjuku 6 chome, Shinjuku ku, Tokyo 160 8402, Japan
    Neurosci Res 70:16-23. 2011
    ..Mitochondria-deficient synapses with impaired anterograde transport of mitochondria in neuronal processes show defects in presynaptic short-term plasticity...
  73. pmc Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission
    Samantha A Spangler
    Department of Neuroscience, Erasmus Medical Center, 3015GE Rotterdam, Netherlands
    J Cell Biol 201:915-28. 2013
    ..after photobleaching showed that depletion of liprin-α2 resulted in reduced turnover of RIM1 and CASK at presynaptic terminals, suggesting that liprin-α2 promotes dynamic scaffolding for molecular complexes that facilitate synaptic ..
  74. pmc Synaptogenesis and outer segment formation are perturbed in the neural retina of Crx mutant mice
    Eric M Morrow
    Department of Genetics and Howard Hughes Medical Institute, Harvard Medical School, New Research Building, Room 360K, NRB, Room 360K, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    BMC Neurosci 6:5. 2005
    ..Mutations in genes that affect the development and/or function of photoreceptor cells have been found to be responsible in some families. These examples include mutations in the photoreceptor transcription factor, Crx...
  75. ncbi Regulation of the exocytotic machinery by cAMP-dependent protein kinase: implications for presynaptic plasticity
    G J O Evans
    Physiological Laboratory, Department of Physiology, Crown St, University of Liverpool, Liverpool L69 3BX, UK
    Biochem Soc Trans 31:824-7. 2003
    ..We also discuss how the function of CSP and Snapin phosphorylation might fit into an interesting aspect of the PKA-dependent enhancement of exocytosis: presynaptic plasticity in the brain...
  76. ncbi Maturation of astrocyte morphology and the establishment of astrocyte domains during postnatal hippocampal development
    Eric A Bushong
    Biomedical Sciences Program, University of California, San Diego, La Jolla 92093 0608, USA
    Int J Dev Neurosci 22:73-86. 2004
    ..These observations suggest that domain formation is largely the consequence of competition between astrocyte processes, similar to the well-studied competitive interactions between certain neuronal dendritic fields...
  77. pmc Independent regulation of basal neurotransmitter release efficacy by variable Ca²+ influx and bouton size at small central synapses
    Yaroslav S Ermolyuk
    UCL Institute of Neurology, University College London, United Kingdom
    PLoS Biol 10:e1001396. 2012
    ....
  78. pmc α-Synuclein inhibits intersynaptic vesicle mobility and maintains recycling-pool homeostasis
    David Scott
    Department of Pathology, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 32:10129-35. 2012
    ....
  79. pmc Activation of silent and weak synapses by cAMP-dependent protein kinase in cultured cerebellar granule neurons
    Michael A Cousin
    Membrane Biology Group, Centre for Integrative Physiology, George Square, University of Edinburgh, Edinburgh EH8 9XD, UK
    J Physiol 589:1943-55. 2011
    ..These data are consistent with the idea that PKA regulates synaptic vesicle recycling downstream of Ca(2+) influx and that this pathway is highly active in recently activated synapses...
  80. ncbi Role of Drosophila alpha-adaptin in presynaptic vesicle recycling
    M Gonzalez-Gaitan
    Max Planck Institut fur biophysikalische Chemie, Abt Molekulare Entwicklungsbiologie, Gottingen, Germany
    Cell 88:767-76. 1997
    ..Here we show its role in presynaptic vesicle recycling. In presynaptic terminals, alpha-adaptin defines a network-like membrane structure to which the GTPase dynamin is recruited...
  81. ncbi Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences
    Richard Fairless
    Institute of Anatomy and Molecular Neurobiology, Westfalische Wilhelms University, D 48149 Munster, Germany
    J Neurosci 28:12969-81. 2008
    ....
  82. ncbi Preferential localization of glutamate receptors opposite sites of high presynaptic release
    Scott B Marrus
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110 USA
    Curr Biol 14:924-31. 2004
    ..Hence, this is an ideal preparation for the investigation of whether receptor clustering is sensitive to the morphological and physiological properties of the apposed active zones...
  83. ncbi Quantitative analysis of calcium-dependent vesicle recruitment and its functional role at the calyx of Held synapse
    Nobutake Hosoi
    Department of Membrane Biophysics, Max Planck Institute for Biophysical Chemistry, 37077 Gottingen, Germany
    J Neurosci 27:14286-98. 2007
    ..We could also demonstrate an approximate sixfold increase in release probability (facilitation) during the initial 5-15 AP-like stimuli of such trains in our experimental condition, regardless of EPSC depression...
  84. ncbi The liprin protein SYD-2 regulates the differentiation of presynaptic termini in C. elegans
    M Zhen
    Department of Biology, Sinsheimer Laboratories, University of California, Santa Cruz 95064, USA
    Nature 401:371-5. 1999
    ..We propose that SYD-2 regulates the differentiation of presynaptic termini in particular the formation of the active zone, by acting as an intracellular anchor for RPTP signalling at synaptic junctions...
  85. ncbi Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages
    David Bartolomé-Martín
    Departamento de Bioquimica, Facultad de Veterinaria, Universidad Complutense, Madrid 28040, Spain
    J Cell Sci 125:422-34. 2012
    ..Furthermore, cell maturation in culture increased the proportion of synaptic boutons that were capable of an intense release response, whereas the chronic blockage of synaptic activity diminished the capacity of boutons to release dye...
  86. pmc Deconstructing complexity: serial block-face electron microscopic analysis of the hippocampal mossy fiber synapse
    Scott A Wilke
    Neurobiology Section, Division of Biological Sciences and National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 33:507-22. 2013
    ....
  87. pmc Calcium-dependent isoforms of protein kinase C mediate posttetanic potentiation at the calyx of Held
    Diasynou Fioravante
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 70:1005-19. 2011
    ..These experiments establish that PKCα and PKCβ are crucial for PTP and suggest that long-lasting presynaptic calcium increases produced by tetanic stimulation may activate these isoforms to produce PTP...
  88. ncbi Pre- and postsynaptic inhibitory control in the spinal cord dorsal horn
    Rita Bardoni
    Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy
    Ann N Y Acad Sci 1279:90-6. 2013
    ....
  89. pmc Synaptotagmin-1 functions as a Ca2+ sensor for spontaneous release
    Jun Xu
    Department of Molecular and Cellular Physiology, Stanford University, Palo Alto, California, USA
    Nat Neurosci 12:759-66. 2009
    ..These data suggest that Syt1 controls both evoked and spontaneous release at a synapse as a simultaneous Ca2+-dependent activator and clamp of exocytosis...
  90. pmc Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
    Konrad Talbot
    Department of Psychiatry Center for Neurobiology and Behavior, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6140, USA
    J Clin Invest 113:1353-63. 2004
    ..Such changes may contribute to the cognitive deficits common in schizophrenia...
  91. ncbi Molecular circuitry of endocytosis at nerve terminals
    Jeremy Dittman
    Department of Biochemistry, Weill Cornell Medical College, New York, NY 10065, USA
    Annu Rev Cell Dev Biol 25:133-60. 2009
    b>Presynaptic terminals are specialized compartments of neurons responsible for converting electrical signals into secreted chemicals...
  92. ncbi In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice
    Etienne Herzog
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    J Neurosci 31:15544-59. 2011
    ..We provide a detailed analysis of synaptic vesicle sharing in vitro, and show that network homeostasis leads to dynamic scaling of synaptic VGLUT1 levels...
  93. ncbi Presynaptic mechanism underlying cAMP-dependent synaptic potentiation
    Masahiro Kaneko
    Department of Neurophysiology, University of Tokyo Graduate School of Medicine, Tokyo 113 0033, Japan
    J Neurosci 24:5202-8. 2004
    ..Bath application of forskolin or intracellular application of cAMP into presynaptic terminals strongly potentiated EPSCs...
  94. ncbi Neuronal activity drives matching of pre- and postsynaptic function during synapse maturation
    Louise Kay
    MRC Centre for Developmental Neurobiology, King s College London, London, UK
    Nat Neurosci 14:688-90. 2011
    ....
  95. pmc β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation
    Yan Cai
    Department of Anatomy and Neurobiology, Central South University Xiangya Medical School, Changsha, Hunan, China
    Eur J Neurosci 32:1223-38. 2010
    ..The data provide a mechanistic explanation for why senile plaques are present preferentially near the cerebral vasculature...
  96. ncbi Novel presynaptic mechanisms for coincidence detection in synaptic plasticity
    Ian Duguid
    Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Neurobiol 16:312-22. 2006
    ..Recent studies also indicate the existence of presynaptic coincidence detection that is independent of NMDA receptors, suggesting that such mechanisms have a widespread role in plasticity...
  97. pmc Synaptic heterogeneity between mouse paracapsular intercalated neurons of the amygdala
    Raffaella Geracitano
    MRC Anatomical Neuropharmacology Unit, Mansfield Road, Oxford OX1 3TH, UK
    J Physiol 585:117-34. 2007
    ....
  98. pmc Exchange and redistribution dynamics of the cytoskeleton of the active zone molecule bassoon
    Shlomo Tsuriel
    Department of Physiology, Technion Faculty of Medicine, Lorry Lokey Interdisciplinary Center for Life Sciences and Engineering, The Rappaport Family Institute for Research in the Medical Sciences, Haifa, Israel
    J Neurosci 29:351-8. 2009
    ..Our findings indicate that Bassoon is engaged in relatively stable associations within the CAZ and thus support the notion that the CAZ or some of its components might constitute a relatively stable presynaptic core scaffold...
  99. ncbi EphA4 signaling in juveniles establishes topographic specificity of structural plasticity in the hippocampus
    Ivan Galimberti
    Friedrich Miescher Institut, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Neuron 65:627-42. 2010
    ..Therefore, plastic synapse specification in juveniles defines sites of synaptic remodeling in the adult, and hippocampal circuit plasticity follows unexpected topographic principles...
  100. pmc Transmitter release modulation by intracellular Ca2+ buffers in facilitating and depressing nerve terminals of pyramidal cells in layer 2/3 of the rat neocortex indicates a target cell-specific difference in presynaptic calcium dynamics
    A Rozov
    Abteilung Zellphysiologie, Max-Planck-Institut fur medizinische Forschung, Jahnstrasse 29, D-69120 Heidelberg, Germany
    J Physiol 531:807-26. 2001
    ..This would lead to a lower [Ca2+] at release sites and would also explain the higher apparent K(D) of the Ca2+ sensor in facilitating terminals...
  101. pmc Neuropeptide delivery to synapses by long-range vesicle circulation and sporadic capture
    Man Yan Wong
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    Cell 148:1029-38. 2012
    ..Therefore, vesicle circulation, which includes long-range retrograde transport and inefficient bidirectional capture, overcomes the limitations of one-way anterograde transport to uniformly supply release sites with DCVs...

Research Grants63

  1. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..in hippocampal slices can enhance excitatory neurotransmission by stimulating glutamate release from presynaptic terminals. These findings lead to the formulation of the central hypothesis guiding this proposal: convulsant ..
  2. Presynaptic NMDAR Regulation of Substance P Release in the RVM After Injury
    UCHECHUKWU PATRICK MADUKA; Fiscal Year: 2013
    ..the ability of glutamate or NMDA to promote the release of substance P will be investigated in isolated presynaptic terminals (synaptosomes) from the RVM of rats that received an intraplantar injection of saline- or CFA four hrs, ..
  3. Regulation of Synapse Morphogenesis in Drosophila
    David L Van Vactor; Fiscal Year: 2013
    ..of multiple stimuli and regulatory pathways, miR-8 is required in muscle cells to promote the growth of presynaptic terminals. Our analysis suggests that miR-8 is required for the normal architecture of the cytomatrix which defines ..
  4. Homeostatic Regulation of Presynaptic Function by Dendritic mTORC1
    FREDRICK EARL HENRY; Fiscal Year: 2013
    ..local translational program in dendrites that functions to modulate neurotransmitter release from apposed presynaptic terminals. Guided by extensive preliminary data collected in the applicant's laboratory, this hypothesis will ..
  5. PRESYNAPTIC LONG-TERM SYNAPTIC DEPRESSION
    Patric K Stanton; Fiscal Year: 2012
    ..oxide (NO), production of cyclic GMP and inhibition of cyclic AMP-dependent protein kinase, which acts on presynaptic terminals to persistently reduce transmitter release...
  6. G Protein Coupled Receptor Modulation of Synaptic Transmission
    EDAENI YISHAK HAMID; Fiscal Year: 2010
    ..In hippocampus, the 5-HT1B receptor is expressed on presynaptic terminals of CA1 pyramidal cells that synapse locally and also project to the subiculum and entorhinal cortex...
  7. FUNCTIONAL ANALYSIS OF CALCIUM CHANNEL MUTATIONS IN TRIGEMINAL NOCICEPTION
    Yuqing Cao; Fiscal Year: 2010
    ..a key player in supporting voltage-dependent Ca2+ entry that is critical for neurotransmitter release at presynaptic terminals and postsynaptic Ca2+ signaling in soma and dendrites...
  8. Molecular mechanisms of aging in the intrinsic laryngeal muscles
    Colleen McMullen; Fiscal Year: 2009
    ..Specific Aim 3 will assess to what extent age alters the acetylcholine vesicle release system in the presynaptic terminals of the intrinsic laryngeal NMJs...
  9. Investigating the Role of Atg1 in the Regulation of Glutamate Receptors
    Faith Liebl; Fiscal Year: 2009
    ..This process is dependent upon the spatially correct formation of presynaptic terminals and the localization of postsynaptic receptors...
  10. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2013
    ..BDNF) is required for synaptic AMPAR incorporation and conditioning, and morphological alterations of presynaptic terminals. Here, we will assess whether the coordinate pre- and postsynaptic modifications that occur during ..
  11. Vesicular retrieval and reuse at CNS nerve terminals
    Richard W Tsien; Fiscal Year: 2012
    ..to a single quantum dot (Qdot), will allow us to assess the prevalence of K&R and reuse in whole presynaptic terminals. The pH signals from single vesicles, and possibly signals reflecting chloride and glutamate ..
  12. Glucocorticoids and endocannabinoids in vagal complex
    Bret N Smith; Fiscal Year: 2013
    ..Both effects occur by activation of receptors on presynaptic terminals. Preliminary evidence suggests that eCB ligands are released from DMV neurons, and that glucocorticoids or ..
  13. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2012
    ..The LFP represents synchronized sub- and supra-threshold activity in presynaptic terminals and postsynaptic neurons...
  14. Presynaptic Release of Endocannabinoids in the Nucleus Accumbens
    Yanhua H Huang; Fiscal Year: 2013
    ..acylphosphatidylethanolamine phospholipase D (NAPE-PLD), an enzyme that synthesizes AEA, is identified in presynaptic terminals within the NAc...
  15. Chronic Ethanol's Effects on Endocannabinoid Modulation of Neocrotical Up-states
    Matthew J Pava; Fiscal Year: 2010
    ..In the cortex, CBI is localized to presynaptic terminals at both glutamatergic and GABAergic synapses, and activation of CBI at either type of synapse results in ..
  16. Stress Regulation of Synaptic Transmission
    Derek Sieburth; Fiscal Year: 2013
    ..We found that WDR-23 promotes the secretion of neurotransmitter from presynaptic terminals by antagonizing the activity of the transcription factor SKN-1...
  17. The role of spontaneous neurotransmission in synaptic plasticity and behavior
    Devon C Crawford; Fiscal Year: 2013
    ..Canonically, calcium entry during action potential stimulation of presynaptic terminals causes synchronous fusion of many synaptic vesicles arising from multiple synapses...
  18. Role of Rab-5 regulators in neuronal development
    Sharon B Sann; Fiscal Year: 2012
    ..The Rab-5 GTPase is associated with canonical early endosomes, and known to be present in presynaptic terminals. Previous research has shown that biasing the cycling state of Rab-5 towards a primarily GTP-bound form ..
  19. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..CBIRs are localized to presynaptic terminals of cholecystokinin-(CCK) expressing basket cells, a class of GABAergic interneurons...
  20. Mechanisms of Synaptic Specificity in C. elegans
    Kang Shen; Fiscal Year: 2013
    ..suggesting that molecular mechanisms regulate the assembly of synaptic vesicle precursors locally at the presynaptic terminals. When the appropriate number of vesicles is recruited, there might be a negative feedback system to shut ..
  21. Dopaminergic modulation of dentritic excitability
    Srdjan D Antic; Fiscal Year: 2010
    ..strongly implicated in pathophysiology of schizophrenia) individual dendritic spines are occupied by two presynaptic terminals;one axon terminal that secretes the excitatory transmitter (glutamate), and the other one that secretes ..
  22. Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
    RYAN MICHAEL DRENAN; Fiscal Year: 2010
    ..I will test the idea that nicotinic receptors containing 16 subunits, which are found on dopamine presynaptic terminals, are important mediators of dopamine release...
  23. Food Reward and Stress
    YVONNE MICHELLE ULRICH-LAI; Fiscal Year: 2013
    ..In support of this idea, immunolabeling for synaptophysin (a marker of presynaptic terminals), phosphorylated cAMP response element-binding protein (pCREB;a postsynaptic marker associated with ..
  24. Glial-cytokine-neuronal interactions in neuropathic pain
    Han Rong Weng; Fiscal Year: 2012
    ..of pain singals have mainly focused either on the presynaptic levels to block glutamate release from presynaptic terminals or on the postsynaptic levels to block glutamate receptors and glutamate activated signal transduction ..
  25. Excitatory and inhibitory synaptogenesis by FGFs and their role in epilepsy
    Hisashi Umemori; Fiscal Year: 2013
    ..We have recently found that FGF22 and FGF7 promote the organization of excitatory and inhibitory presynaptic terminals, respectively, as target-derived presynaptic organizers in the hippocampus...
  26. A conditional, tissue specific 5-HT1B knockout mouse
    John F Neumaier; Fiscal Year: 2013
    ..are expressed in diverse neuron types throughout the brain where they act as inhibitory receptors on presynaptic terminals. When expressed by serotonergic neurons they are autoreceptors whereas in other types of neurons they act ..
  27. MODULATION OF NEOCORTICAL INTERNEURONAL FUNCTION
    DAVID ALLAN PRINCE; Fiscal Year: 2013
    ..produced by actions of neuropeptide Y and GABA at their receptors and selective Ca++ current blockers on presynaptic terminals of major classes of inhibitory interneurons...
  28. GABA Channel Activation Domains and Mechanisms
    David S Weiss; Fiscal Year: 2013
    ..GABA, released from presynaptic terminals, binds to postsynaptic GABA receptors thereby gating an integral chloride pore...
  29. Roles of Kainate Receptors in Compulsive-Like Behaviors
    Jian Xu; Fiscal Year: 2013
    ..mediated transduction of cortical neurons followed by two-photon laser scanning microscopy (2PLSM) of presynaptic terminals in striatum will be used to determine whether kainate receptors modulate corticostriatal synapses...
  30. Mechanisms of Endosome Trafficking in Neurons
    Victor Faundez; Fiscal Year: 2012
    A defining feature of presynaptic terminals is the presence of synaptic vesicles (SVs), secretory organelles that store and secrete neurotransmitters. SVs functions are specified by the organelle membrane protein composition...
  31. Cocaine-induced Adaptation in NMDA receptors
    Yan Dong; Fiscal Year: 2013
    ..synapse-based synaptic re-organization within the BLA-to-NAc afferent is initiated by the formation of new presynaptic terminals and new postsynaptic partners enriched in NR2B subunit- containing NMDARs;and ii) is completed by ..
  32. Mechanisms of Synapse Formation: Function and Trafficking of Presynaptic NMDARs
    SHASTA SABO; Fiscal Year: 2013
    ..1 will test the novel hypothesis that NMDA receptors control the biochemical differentiation of excitatory presynaptic terminals in cerebral cortical neurons in a cell-autonomous manner...
  33. Molecular Basis of Infantile NCL
    Sandra L Hofmann; Fiscal Year: 2010
    ..spontaneous and evoked neurotransmitter release, fluorescent dye imaging, and ultrastructural analysis of presynaptic terminals in cortical and hippocampal cultures derived from PPT1 knockout and control mice...
  34. Development of a model system for presynaptic study
    David Zenisek; Fiscal Year: 2009
    ..We intend to extend the utility of this preparation to the study of the physiology of presynaptic terminals from ribbon-type synapses after vision has been established...
  35. NOVELTY, DOPAMINE AND RESPONSE TO AMPHETAMINE
    Michael T Bardo; Fiscal Year: 2013
    ..behavioral changes are accompanied by a reduction in uptake and metabolism of dopamine (DA) in presynaptic terminals in medial prefrontal cortex (mPFC), a brain region known to be involved in both drug reward and behavioral ..
  36. Synaptic mechanisms of auditory memory
    Stanislav S Zakharenko; Fiscal Year: 2013
    ..gating mechanisms during postnatal development that can be released by activating cholinergic receptors on presynaptic terminals of TC projections...
  37. Control of cortico-limbic feeding behavior using optogenetics
    Benjamin B Land; Fiscal Year: 2012
    ..specific wavelengths to either excite (with channelrhodopsin) or inhibit (with halorhodopsin) only those presynaptic terminals arriving from the prefrontal cortex in accumbens, allowing unprecedented spatial selectivity...
  38. Synapse Maturation by Activity-Dependent Ectodomain Shedding of SIRP
    Hisashi Umemori; Fiscal Year: 2012
    ..cluster synaptic vesicles in cultured neurons as a bioassay, we have purified molecules that can organize presynaptic terminals from developing brains...
  39. Alpha6* nAChRs in Dopamine Transmission and Nicotine Dependence
    RYAN MICHAEL DRENAN; Fiscal Year: 2013
    ..will test the idea that nicotinic receptors containing [unreadable]6 subunits, which are found on dopamine presynaptic terminals, are important mediators of dopamine release...
  40. HIV Neurotoxicity-Mechanism &Modulation by Cannabinoids
    Stanley A Thayer; Fiscal Year: 2013
    ..from synapse loss requires changes in NMDA receptor function and is guided by the location of pre-existing presynaptic terminals will be tested...
  41. 2014 Synaptic Transmission Gordon Research Conference and Gordon Research Seminar
    Peter Jonas; Fiscal Year: 2013
    ..eight sessions that address different aspects of synaptic signaling, including mechanisms of exocytosis, presynaptic terminals, synaptic spines, pre- and postsynaptic plasticity, connectomics, synaptic diseases, and function of ..
  42. Regulation of HCN channel trafficking and function in the brain by TRIP8b
    Steven A Siegelbaum; Fiscal Year: 2013
    ..HCN1 is targeted to distal dendrites in hippocampal CA1 pyramidal neurons, the channel is targeted to presynaptic terminals in inhibitory basket cells. Moreover the pattern of channel expression is dynamic...
  43. Inhibitory synaptic control of social avoidance behavior
    Mitra Heshmati; Fiscal Year: 2013
    ..Preliminary data also shows a decrease in inhibitory presynaptic terminals in the NAc following chronic social defeat stress...
  44. Translational regulation of glutamate transporter EAAT2 & therapeutic application
    Chien Liang Glenn Lin; Fiscal Year: 2010
    ..Under disease conditions, elevated extracellular glutamate concentrations can occur when the release from presynaptic terminals is augmented or when the reuptake from the synaptic cleft is insufficient...
  45. Induction pathways in hippocampal adaptive synaptic plasticity
    Devon C Crawford; Fiscal Year: 2010
    ..In glutamatergic neurons of the hippocampus, the number of functionally active presynaptic terminals is decreased after prolonged periods of increased activity...
  46. ROLE OF PEPTIDES IN OCULOMOTOR NEUROTRANSMISSION
    VINCENT CHIAPPINELLI; Fiscal Year: 1992
    ..The cell bodies of autonomic ganglion cells in this pathway are located in the ciliary ganglion. All presynaptic terminals in the ciliary ganglion originate in the midbrain in the Edinger-Westphal nucleus...
  47. Regulation of HCN channel trafficking and function in the brain by TRIP8b
    Steven A Siegelbaum; Fiscal Year: 2012
    ..HCN1 is targeted to distal dendrites in hippocampal CA1 pyramidal neurons, the channel is targeted to presynaptic terminals in inhibitory basket cells. Moreover the pattern of channel expression is dynamic...
  48. Labeling of Cocaine-generated Nascent Excitatory Synapses
    Yan Dong; Fiscal Year: 2012
    ..Our strategy is to split GFP into two halves, one expressed in potential presynaptic terminals and the other in potential postsynaptic terminals...
  49. Nicotinic Receptor Effects on Neurophysiology of Dorsolateral Prefrontal Cortex
    Min Wang; Fiscal Year: 2013
    ..a4b2 and a7 nicotinic receptor subtypes are localized on presynaptic terminals in PFC, and a7 receptors are also post-synaptic on spines...
  50. Genetics of New Synaptic Components and Their Functions
    Thomas L Schwarz; Fiscal Year: 2013
    ..The maturation of presynaptic terminals from growth cones to synaptic boutons is a critical late step in synaptogenesis but poorly understood...
  51. NICOTINIC MODULATION OF DOPAMINE RELEASE STUDIED WITH A CHANNEL-BASED BIOSENSOR
    Steven J Mennerick; Fiscal Year: 2013
    ..For instance, nicotine directly modulates dopamine release through nicotinic receptors on presynaptic terminals of dopaminergic neurons...
  52. QUANTITATIVE STUDY OF PRESYNAPTIC FACILITATION
    Maria Bykhovskaia; Fiscal Year: 2010
    ..Our proposal relies on the combination of experimentation and modeling, since presynaptic terminals are not easily accessible for experimental manipulations, and all the vesicle pools cannot be measured ..
  53. Axonal Signaling in the Hippocampus
    Steven J Mennerick; Fiscal Year: 2010
    ..summary: Axons are typically viewed as an all-or-none transmission line between the neuronal soma and presynaptic terminals. To test this assumption, we circumvented some of the limitations of classic techniques for studying ..
  54. AGE RELATED SYNAPTIC CHANGES IN THE AUDITORY BRAINSTEM
    Robert Helfert; Fiscal Year: 1999
    ..in GABA-mediated inhibition, alterations in the levels of EAA receptors, and loss of "excitatory-type" presynaptic terminals similar to those that use an EAA neurotransmitter...
  55. GLUTAMATE TRANSPORT IN EXCITOTOXIC CELL DEATH
    Margaret Sutherland; Fiscal Year: 1999
    ..acid neurotransmitters from the synaptic cleft occurs through diffusion and reuptake of glutamate into presynaptic terminals and surrounding glial cells via high-affinity neuronal and glial glutamate transporters...
  56. PSYCHOSTIMULANT ACTION AT MESOACCUMBENS SYNAPSES
    Stephen Rayport; Fiscal Year: 1999
    ..This is due to action at the presynaptic terminals of ventral tegmental area dopamine neurons...
  57. MOLECULAR INTERACTIONS OF BRAIN SPECTRIN
    Leszek Kotula; Fiscal Year: 1999
    ..Neuronal compartmentalization of brain spectrin isoforms into axons and presynaptic terminals (nonerythroid spectrin) and into cell body and dendrites (erythroid spectrin) suggests that brain spectrin ..
  58. Voltage-gated calcium channels in taste buds
    Nirupa Chaudhari; Fiscal Year: 2003
    ..In most neurons, transmitter release at presynaptic terminals is dependent upon voltage-gated calcium channels (VGCCs)...
  59. Cannabinoid modulation of epileptiform activity in mice
    Bret Smith; Fiscal Year: 2006
    ..central effects of cannabinoids are mediated by cannabinoid type 1 receptors (CB1R), usually located on presynaptic terminals. In the hippocampus, cannabinoids suppress synaptic input-especially feedback inhibition--to principal ..
  60. METABOTROPIC GLUTAMATE RECEPTORS IN BASAL GANGLIA
    COLLEEN NISWENDER; Fiscal Year: 2009
    ..mGlu4 is localized on presynaptic terminals in the synapse between the striatum an the globus pallidus (the striato-pallidal synapse)...
  61. Mechanisms of Vesicle Exocytosis at Tonic Synapses
    George Zanazzi; Fiscal Year: 2009
    ..The presynaptic terminals of photoreceptors and bipolar cells contain varying numbers of an organelle, the synaptic ribbon, which ..
  62. Innervation-Dependent Transcription
    STEVEN BURDEN; Fiscal Year: 2004
    ..program in the synaptic region, and signals from the muscle in turn regulate the differentiation of the presynaptic terminals. Two different transcriptional signaling pathways lead to the localization of acetylcholine receptors (..
  63. PROTEIN PHISPHORYLATION AND NEUROSECRETION
    Michael Browning; Fiscal Year: 1990
    ..Moreover, this protein is localized in presynaptic terminals in association with synaptic vesicles...