sural nerve

Summary

Summary: A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.

Top Publications

  1. ncbi The spectrum of neuropathy in diabetes and impaired glucose tolerance
    C J Sumner
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 60:108-11. 2003
  2. ncbi Enhancement of axonal potassium conductance reduces nerve hyperexcitability in an in vitro model of oxaliplatin-induced acute neuropathy
    Ruth Sittl
    Institute of Physiology, Ludwig Maximilians University, Pettenkoferstr 12, Munich, Germany
    Neurotoxicology 31:694-700. 2010
  3. pmc Function of sural nerve reflexes during human walking
    E P Zehr
    Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Physiol 507:305-14. 1998
  4. ncbi Pathology and pathogenetic mechanisms of diabetic neuropathy: correlation with clinical signs and symptoms
    Soroku Yagihashi
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Diabetes Res Clin Pract 77:S184-9. 2007
  5. ncbi Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination
    L E Warner
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 17:451-60. 1996
  6. ncbi Accuracy of sampling methods in morphometric studies of human sural nerves
    Z Cai
    Department of Neurology and University Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia
    J Clin Neurosci 9:181-6. 2002
  7. ncbi Automated morphometric analysis in peripheral neuropathies
    P Campadelli
    Dipartimento di Scienze dell Informazione, Universita degli Studi di Milano, Milan, Italy
    Comput Biol Med 29:147-56. 1999
  8. ncbi Peculiarities of the sural nerve complex morphologic types in human fetuses
    S Ugrenovic
    Institute of Anatomy, Faculty of Medicine Nis, Brace Taskovica Blvd 81, 18000, Nis, Serbia, Serbia and Montenegro
    Surg Radiol Anat 27:25-9. 2005
  9. ncbi An ultrasound study of anatomic variants of the sural nerve
    Jiaan Zhu
    Department of Ultrasound, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, China
    Muscle Nerve 43:560-2. 2011
  10. ncbi Two-year outcome of unilateral sural nerve interposition graft after radical prostatectomy
    Hong Gee Sim
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Urology 68:1290-4. 2006

Research Grants

  1. Bioengineered scaffolds for peripheral nerve repair
    Ravi V Bellamkonda; Fiscal Year: 2010
  2. Biomarkers in Diabetic Neuropathy
    EVA LUCILLE FELDMAN; Fiscal Year: 2010
  3. Mechanisms of HIV-Induced PNS Disease: The SIV Macaque Model
    Joseph Mankowski; Fiscal Year: 2009
  4. Rho GTPases and Neuroprotection Model in Cancer Therapy
    Qun Lu; Fiscal Year: 2012
  5. OPTIC NEUROPATHY FROM MITOCHONDRIAL DERANGEMENT
    Alfredo Sadun; Fiscal Year: 1999
  6. Supraspinal Modulation of Neuropathic Pain
    Bradley Taylor; Fiscal Year: 2007
  7. MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDEN
    Benjamin Gelman; Fiscal Year: 2004
  8. NON-INVASIVE SURROGATE MARKERS FOR DIABETIC NEUROPATHY
    Andrew Boulton; Fiscal Year: 2004
  9. Neurophysiological mechanisms underlying spasms in SCI
    Maria Knikou; Fiscal Year: 2004
  10. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002

Detail Information

Publications220 found, 100 shown here

  1. ncbi The spectrum of neuropathy in diabetes and impaired glucose tolerance
    C J Sumner
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 60:108-11. 2003
    ..To compare the neuropathy associated with impaired glucose tolerance (IGT) and diabetes mellitus (DM) determined by oral glucose tolerance testing (OGTT)...
  2. ncbi Enhancement of axonal potassium conductance reduces nerve hyperexcitability in an in vitro model of oxaliplatin-induced acute neuropathy
    Ruth Sittl
    Institute of Physiology, Ludwig Maximilians University, Pettenkoferstr 12, Munich, Germany
    Neurotoxicology 31:694-700. 2010
    ..These findings were also confirmed in isolated human sural nerve segments...
  3. pmc Function of sural nerve reflexes during human walking
    E P Zehr
    Division of Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    J Physiol 507:305-14. 1998
    ..of ipsilateral cutaneous reflexes were studied with short trains of stimuli presented pseudorandomly to the sural nerve during human walking...
  4. ncbi Pathology and pathogenetic mechanisms of diabetic neuropathy: correlation with clinical signs and symptoms
    Soroku Yagihashi
    Department of Pathology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    Diabetes Res Clin Pract 77:S184-9. 2007
    ..Clinical trials based on this background confirmed that fundamental treatment is in fact beneficial for the prevention and halting of this intractable disorder...
  5. ncbi Clinical phenotypes of different MPZ (P0) mutations may include Charcot-Marie-Tooth type 1B, Dejerine-Sottas, and congenital hypomyelination
    L E Warner
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 17:451-60. 1996
    ..Furthermore, we hypothesize the differences in clinical severity seen with mutations in MPZ are related to the type of mutation and its subsequent effect on protein function (i.e., loss of function versus dominant negative)...
  6. ncbi Accuracy of sampling methods in morphometric studies of human sural nerves
    Z Cai
    Department of Neurology and University Department of Neurology, Royal Adelaide Hospital, Adelaide, South Australia
    J Clin Neurosci 9:181-6. 2002
    ..fibre density (MFD), myelinated fibre diameter (Ds) and axonal diameter (Da) in morphometric studies of sural nerve biopsies...
  7. ncbi Automated morphometric analysis in peripheral neuropathies
    P Campadelli
    Dipartimento di Scienze dell Informazione, Universita degli Studi di Milano, Milan, Italy
    Comput Biol Med 29:147-56. 1999
    ..The results obtained on 25 images are reported and compared with corresponding measurements made by neurologists...
  8. ncbi Peculiarities of the sural nerve complex morphologic types in human fetuses
    S Ugrenovic
    Institute of Anatomy, Faculty of Medicine Nis, Brace Taskovica Blvd 81, 18000, Nis, Serbia, Serbia and Montenegro
    Surg Radiol Anat 27:25-9. 2005
    The sural nerve is the most frequently used sensory nerve in nerve transplantation. It can be transplanted alone or together with the other elements of the neurovascular stalk within the superficial sural flap...
  9. ncbi An ultrasound study of anatomic variants of the sural nerve
    Jiaan Zhu
    Department of Ultrasound, Shanghai Jiao Tong University Affiliated Sixth People s Hospital, 600 Yishan Road, Shanghai 200233, China
    Muscle Nerve 43:560-2. 2011
    There are anatomic variations of the sural nerve (SN). Knowledge of these morphological types and the length of the SN are important for planning surgical reconstruction of peripheral nerves...
  10. ncbi Two-year outcome of unilateral sural nerve interposition graft after radical prostatectomy
    Hong Gee Sim
    Department of Urology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Urology 68:1290-4. 2006
    To study 41 men treated for prostate cancer with unilateral nerve-sparing radical prostatectomy and contralateral sural nerve grafting from January 2000 to September 2003.
  11. ncbi Autogenous grafts/allografts/conduits for bridging peripheral trigeminal nerve gaps
    Larry M Wolford
    Department of Oral and Maxillofacial Surgery, Texas A and M University Health Science Center, Baylor College of Dentistry, Dallas, TX, USA
    Atlas Oral Maxillofac Surg Clin North Am 19:91-107. 2011
    ..However, more research studies using these materials for TN repairs are essential to validate the superiority of these procedures...
  12. ncbi 147th ENMC international workshop: guideline on processing and evaluation of sural nerve biopsies, 15-17 December 2006, Naarden, The Netherlands
    C Sommer
    Department of Neurology, University of Wurzburg, Wurzburg, Josef Schneider Str 11, 97080 Wurzburg, Germany
    Neuromuscul Disord 18:90-6. 2008
  13. pmc Parallel facilitatory reflex pathways from the foot and hip to flexors and extensors in the injured human spinal cord
    Maria Knikou
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, and Department of Physical Medicine and Rehabilitation, Feinberg Medical School, Northwestern University, Chicago, IL 60611, USA
    Exp Neurol 206:146-58. 2007
    ..The interactive effects of these sensory signals may be a feature of impaired gait, but when they are appropriately excited, they may contribute to locomotion recovery in these patients...
  14. ncbi Human intracranially-recorded cortical responses evoked by painful electrical stimulation of the sural nerve
    R Dowman
    Department of Psychology, Clarkson University, Potsdam, NY 13699 5825, USA
    Neuroimage 34:743-63. 2007
    ..SEP) components that appear to be involved in orienting attention towards a potentially threatening, painful sural nerve electrical stimulus...
  15. pmc Hip-phase-dependent flexion reflex modulation and expression of spasms in patients with spinal cord injury
    Maria Knikou
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, Chicago, IL 60610, USA
    Exp Neurol 204:171-81. 2007
    ..The flexion reflex was elicited by low-intensity stimulation (300 Hz, 30 ms pulse train) of the right sural nerve at the lateral malleolus, and recorded from the tibialis anterior (TA) muscle...
  16. ncbi Randomized phase II trial evaluation of erectile function after attempted unilateral cavernous nerve-sparing retropubic radical prostatectomy with versus without unilateral sural nerve grafting for clinically localized prostate cancer
    John W Davis
    Department of Urology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Eur Urol 55:1135-43. 2009
    Nonrandomized studies of unilateral nerve-sparing (UNS) radical prostatectomy (RP) have reported improved recovery of erectile function if the sacrificed cavernous nerve is reconstructed with a sural nerve graft (SNG).
  17. ncbi Clinical utility of dorsal sural nerve conduction studies in healthy and diabetic children
    Nilda Turgut
    Department of Neurology, Trakya University Medical Faculty, 22030 Edirne, Turkey
    Clin Neurophysiol 115:1452-6. 2004
    ..We tried to determine the normal dorsal sural nerve conduction values of the childhood population and assessed the clinical utility of this method in diabetic ..
  18. ncbi A comparison of nerve regeneration across a sural nerve graft and a vascularized pseudosheath
    S E Mackinnon
    Division of Plastic Surgery and Neurosurgery, University of Toronto, Ont, Canada
    J Hand Surg Am 13:935-42. 1988
    Nerve regeneration across a vascularized pseudosheath and a sural nerve graft was compared in a primate model using histologic and electrophysiologic parameters for regeneration...
  19. ncbi Is laparoscopic unilateral sural nerve grafting during radical prostatectomy effective in retaining sexual potency?
    Francesco Porpiglia
    Division of Urology, Department of Clinical and Biological Sciences, University of Turin San Luigi Hospital, Turin, Italy
    BJU Int 95:1267-71. 2005
    To present a pilot study of laparoscopic unilateral sural nerve grafting during radical prostatectomy, with the aim of preserving sexual potency.
  20. ncbi The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve
    Ruth Sittl
    Institute of Physiology, University of Munich, Munich, Germany
    J Peripher Nerv Syst 15:63-72. 2010
    ..the effect of flupirtine on the electrical excitability of myelinated axons in isolated segments of rat sural nerve. Axonal excitability was studied in vitro with the same parameters used by clinical neurophysiologists to ..
  21. ncbi Sex-related difference in collateral sprouting of nociceptive axons after peripheral nerve injury in the rat
    U Kovacic
    Institute of Pathophysiology, Medical Faculty, University of Ljubljana, Zalosbreve ka 4, 1000, Ljubljana, Slovenia
    Exp Neurol 184:479-88. 2003
    ..Eight weeks after nerve injury, skin pinch tests revealed that the nociceptive area of the noninjured sural nerve in the instep skin expanded faster in females; the final result was a 30% larger increase in females than in ..
  22. ncbi Ultrasound-guided needle positioning in sensory nerve conduction study of the sural nerve
    Christian P Kamm
    Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Switzerland
    Clin Neurophysiol 120:1342-5. 2009
    To evaluate the usefulness of ultrasound imaging to improve the positioning of the recording needle for nerve conduction studies (NCS) of the sural nerve.
  23. ncbi A comparison of sural nerve conduction studies in patients with impaired oral glucose tolerance test
    A Kocer
    Duzce Medical Faculty, Neurology Department, Duzce University, Duzce Turkey
    Acta Neurol Scand 116:399-405. 2007
    Monitoring of the sural nerve is a sensitive method for detection of neuropathies. We examined different methods of studying sural nerve conduction in a group of patients with impaired glucose tolerance (IGT) in the same study.
  24. ncbi Ultrasound imaging of the sural nerve: ultrasound anatomy and rationale for investigation
    S Ricci
    Università Campus Bio Medico di Roma, Area di Geriatria, Centro per la Salute dell Anziano, Roma, Italy
    Eur J Vasc Endovasc Surg 39:636-41. 2010
    Damage to the sural nerve (SuN) may arise from surgical stripping or thermal ablation of the small saphenous vein (SSV).
  25. ncbi Sorbitol and myo-inositol levels and morphology of sural nerve in relation to peripheral nerve function and clinical neuropathy in men with diabetic, impaired, and normal glucose tolerance
    G Sundkvist
    Department of Endocrinology, University of Lund, Malmo University Hospital, Sweden
    Diabet Med 17:259-68. 2000
    Sorbitol and myo-inositol levels and morphology of sural nerve were compared with nerve function and clinical neuropathy in men with diabetic, impaired (IGT), and normal glucose tolerance.
  26. ncbi Identification of the characteristic vascular changes in a sural nerve biopsy of a case with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
    J M Schroder
    Institute of Neuropathology, Medical Faculty, Technical University Aachen, Germany
    Acta Neuropathol 89:116-21. 1995
    ..that similar vascular changes as described in the central nervous system are present in blood vessels of the sural nerve, although less pronounced and, therefore, affording electron microscopy for their unequivocal detection...
  27. ncbi A modified approach to sural nerve biopsy: minimizing complications
    Ivica Ducic
    Department of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA
    Ann Plast Surg 62:220-2. 2009
    The traditional sural nerve biopsy is performed through a distal incision at or just above the ankle. Although a simple procedure, these biopsies are associated with significant morbidity...
  28. ncbi Sural nerve donor-site morbidity: thirty-four years of follow-up
    Frank F A IJpma
    University Medical Centre Groningen, Groningen, The Department of Plastic Surgery, Groningen, The Netherlands
    Ann Plast Surg 57:391-5. 2006
    This study presents a long-term evaluation of sural nerve donor-site morbidity in patients with at least 15 years' follow-up (mean 26 years) after sural nerve harvesting for peripheral nerve repair...
  29. ncbi Topographic analysis of painful laser and sural nerve electrical evoked potentials
    Robert Dowman
    Department of Psychology, Clarkson University, Potsdam, NY 13699 5825, USA
    Brain Topogr 16:169-79. 2004
    ..was used to compare evoked potentials elicited by painful laser (LEP) and electrical stimulation of the sural nerve (snSEP) in 22 healthy adults...
  30. ncbi Utility of dorsal sural nerve in early determination of diabetic polyneuropathy
    Kemal Balci
    J Peripher Nerv Syst 10:342-3. 2005
  31. ncbi Erectile function following unilateral cavernosal nerve replacement
    Gregory R Hanson
    Section of Urology, Virginia Mason Medical Center, Seattle, Washington, USA
    Can J Urol 15:3990-3. 2008
    ..We evaluate a large group of patients who underwent a unilateral cavernosal nerve replacement...
  32. ncbi Diagnostic value of sural nerve biopsy in patients with suspected Borrelia neuropathy
    Maria Schäfers
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 13:81-91. 2008
    ..Standard histology and immunohistochemistry were performed on sural nerve biopsies using antibodies to CD4, CD68 and membrane attack complex C5b-9, intercellular adhesion molecule (ICAM)..
  33. ncbi A clinical test to avoid sural nerve injuries in percutaneous Achilles tendon repairs
    R Flavin
    Department of Trauma and Orthopaedics, St Vincent s University Hospital, Elm Park, Dublin 4, Ireland
    Injury 38:845-7. 2007
    ..due the reduced incidence of wound complications, however its use is still limited by the high incidence of sural nerve injuries associated with these repairs...
  34. ncbi Macrophage clustering as a diagnostic marker in sural nerve biopsies of patients with CIDP
    C Sommer
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    Neurology 65:1924-9. 2005
    ..The authors previously observed clustering of macrophages around endoneurial blood vessels in sural nerve biopsies from patients with CIDP.
  35. ncbi Anatomical variations of the sural nerve in the leg: a fetal study
    Nachiket Shankar
    Department of Anatomy, St John s Medical College, Bangalore, India
    Neurol India 58:24-8. 2010
    ..importance, numerous studies have been conducted worldwide documenting the anatomical variations of the sural nerve (SN)...
  36. ncbi The effect of anatomical variation of the sural nerve on nerve conduction studies
    Sung Bom Pyun
    Department of Rehabilitation Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea
    Am J Phys Med Rehabil 87:438-42. 2008
    To investigate the types of sural nerve formation through cadaver study, and to evaluate the relationship between anatomical variation and nerve conduction study (NCS).
  37. ncbi Genetic modification of human sural nerve segments by a lentiviral vector encoding nerve growth factor
    Martijn R Tannemaat
    Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Neurosurgery 61:1286-94; discussion 1294-6. 2007
    ..These problems may be overcome with the use of lentiviral (LV) vectors that direct sustained local transgene expression in cells...
  38. pmc Anatomy of the sural nerve in a computer-assisted model: implications for surgical minimal-invasive Achilles tendon repair
    Musa Citak
    Trauma Department, Hannover Medical School, Hannover, Germany
    Br J Sports Med 41:456-8; discussion 458. 2007
    b>Sural nerve injuries are an evident risk especially of minimal-invasive surgical Achilles tendon repair...
  39. ncbi Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials
    Anders A F Sima
    Department of Pathology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Diabetes Care 28:89-94. 2005
    ..We evaluated frozen databases from two 52-week randomized placebo-controlled clinical diabetic neuropathy trials testing two doses of acetyl-L-carnitine (ALC): 500 and 1,000 mg/day t.i.d...
  40. ncbi The anatomic features of the sural nerve with an emphasis on its clinical importance
    Z Asli Aktan Ikiz
    Medicine Anatomy Department, Gül sokak No 30, D 11, Alsancak, Izmir, 35100, Turkey
    Foot Ankle Int 26:560-7. 2005
    The sural nerve is formed by the union of the medial and lateral cutaneous nerves of the leg that originate from the tibial and common peroneal nerves...
  41. ncbi Increased sural nerve epineurial blood flow in human subjects with painful diabetic neuropathy
    S E M Eaton
    Diabetes Research Unit, Royal Hallamshire Hospital, Glossop Road, Sheffield, UK
    Diabetologia 46:934-9. 2003
    ..The aim of this study was to compare epineurial haemodynamics in patients with chronic painful and painless neuropathy...
  42. ncbi Retigabine reduces the excitability of unmyelinated peripheral human axons
    P M Lang
    Department of Physiology, University of Munich, Pettenkoferstrasse 12, D 80336 Munich, Germany
    Neuropharmacology 54:1271-8. 2008
    ..the effects of retigabine on excitability parameters of C-type nerve fibers in isolated fascicles of human sural nerve. Application of retigabine (3-10 microM) produced an increase in membrane threshold...
  43. ncbi Ameliorative potential of rosiglitazone in tibial and sural nerve transection-induced painful neuropathy in rats
    Vivek Jain
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India
    Pharmacol Res 59:385-92. 2009
    ..of rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, in tibial and sural nerve transection-induced neuropathic pain in rats...
  44. ncbi Sural nerve grafting for long defects of the femoral nerve after resection of a retroperitoneal tumour
    T Tsuchihara
    Department of Orthopaedic Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitami 359 8513, Japan
    J Bone Joint Surg Br 90:1097-100. 2008
    ..We describe two cases of iatrogenic femoral nerve injury which recovered well after reconstruction with long sural nerve grafts...
  45. ncbi Medial dorsal superficial peroneal nerve studies in patients with polyneuropathy and normal sural responses
    Mark Kushnir
    Department of Neurology, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Muscle Nerve 31:386-9. 2005
    ..MDSP) nerves in 52 patients with clinical evidence of mild chronic sensorimotor polyneuropathy and normal sural nerve responses, in order to assess the diagnostic sensitivity and usefulness of MDSP nerve testing in ..
  46. ncbi Graft of pre-injured sural nerve promotes regeneration of corticospinal tract and functional recovery in rats with chronic spinal cord injury
    Shi qing Feng
    Department of Human Physiology and Centre for Neuroscience, Flinders University School of Medicine, Adelaide SA 5001, Australia
    Brain Res 1209:40-8. 2008
    ..The resulting sprouting and growth past the injury site is associated with a significant improvement in locomotor function...
  47. ncbi Avoiding sural nerve injuries during percutaneous Achilles tendon repair
    Martin Majewski
    Department of Orthopaedic Surgery, Kantonsspital Liestal, Rheinstrasse 26, CH 4410 Liestal, Switzerland
    Am J Sports Med 34:793-8. 2006
    b>Sural nerve injury is a reported risk during percutaneous repair of the Achilles tendon.
  48. ncbi Medial plantar nerve conduction studies in healthy controls and diabetics
    Sissel Løseth
    Department of Neurology, Institute of Clinical Medicine, University of Tromsø and University Hospital of North Norway, Tromsø, Norway
    Clin Neurophysiol 118:1155-61. 2007
    ..To collect a reference material of the medial plantar nerve action potential, to test intra/interobserver reliability in healthy controls and to apply the test to a group of patients with diabetes mellitus...
  49. ncbi Calf-contouring surgery of gastrocnemius hypertrophy: selective neurectomy of the sural nerve
    S C Kim
    The Plastic Surgery, 135 894 Gu jeong B D 5F, Sinsa dong 610 5 Kangnam gu, Seoul, Korea
    Aesthetic Plast Surg 32:889-93. 2008
    ..Using a popliteal incision, the sural nerve branches to the medial and/or lateral gastrocnemius muscles were dissected from the posterior tibial nerve...
  50. ncbi Diagnostic value of sural nerve demyelination in chronic inflammatory demyelinating polyneuropathy
    W M Bosboom
    Department of Neurology, University Medical Center Utrecht, The Netherlands
    Brain 124:2427-38. 2001
    ..The objective of the study was to determine the diagnostic value of features of demyelination and inflammation in sural nerve biopsy specimens of patients with chronic inflammatory demyelinating polyneuropathy (CIDP)...
  51. pmc Microscopic anatomy of the sural nerve in the postnatal developing rat: a longitudinal and lateral symmetry study
    André Jeronimo
    Department of Biological Sciences, School of Medicine of Triangulo Mineiro, Uberaba, Minas Gerais, Brazil
    J Anat 206:93-9. 2005
    Rat sural nerve is widely used in experimental studies investigating injury and regeneration of the peripheral nervous system...
  52. ncbi Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy
    Aaron I Vinik
    Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, 23510, USA
    Muscle Nerve 32:619-25. 2005
    ..004; OR = 0.896). For patients with abnormal VDT, preserved sural SNAP identifies a patient population with less severe DPN who may respond to therapeutic intervention in clinical trials...
  53. ncbi Medial plantar and dorsal sural nerve conduction studies increase the sensitivity in the detection of neuropathy in diabetic patients
    Kayihan Uluc
    Marmara University Hospital, Department of Neurology, Tophanelioglu Cad 13 15 Altunizade, 34640 Istanbul, Turkey
    Clin Neurophysiol 119:880-5. 2008
    ..In the present study, we aimed to evaluate the medial plantar and dorsal sural NCS in a group of diabetic patients with distal sensory neuropathy (DSN) and in healthy controls...
  54. ncbi Superficial peroneal sensory and sural nerve conduction studies in peripheral neuropathy
    Y L Lo
    Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Outram Road, Singapore 169608, Singapore
    J Clin Neurosci 13:547-9. 2006
    ..5%) was significantly higher (P<0.001) compared with sural NCS (75%). The superficial peroneal NCS appeared to have a higher detection rate for peripheral neuropathy in our study, and its study can be adjunctive to sural NCS...
  55. ncbi Clinical utility of dorsal sural nerve conduction studies
    J M Killian
    Department of Neurology, Baylor College of Medicine, 6501 Fannin, Suite NB302 Houston, Texas 77030, USA
    Muscle Nerve 24:817-20. 2001
    A technique of testing sensory nerve conduction of the dorsal sural nerve in the foot was used in 38 normal subjects and 70 patients with peripheral neuropathies...
  56. ncbi Effect of hydroalcoholic extract of Acorus calamus on tibial and sural nerve transection-induced painful neuropathy in rats
    Arunachalam Muthuraman
    Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, India
    J Nat Med 65:282-92. 2011
    ..to investigate the therapeutic potential of hydroalcoholic extracts of Acorus calamus (AC) in tibial and sural nerve transection (TST)-induced neuropathic pain in rats...
  57. ncbi Critical illness polyneuromyopathy: the electrophysiological components of a complex entity
    Josef Bednarik
    Department of Neurology, University Hospital, Masaryk University, Jihlavska 20, 63900 Brno, The Czech Republic
    Intensive Care Med 29:1505-14. 2003
    ..To evaluate the spectrum and time profile of electrophysiological parameters in the detection of neuromuscular involvement in critically ill patients and establish their correlation with biopsy findings...
  58. pmc Does the tibial and sural nerve transection model represent sympathetically independent pain?
    Dong Woo Han
    Department of Anesthesiology, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea
    Yonsei Med J 47:847-51. 2006
    ..Rats with tibial and sural nerve transection (TST) produce neuropathic pain behaviors, including spontaneous pain, tactile allodynia, and cold ..
  59. ncbi Cytokines in sural nerve biopsies from inflammatory and non-inflammatory neuropathies
    Thies Lindenlaub
    , Josef Schneider Strasse 11, 97080, , Germany
    Acta Neuropathol 105:593-602. 2003
    ..Here we studied the cytokine expression in sural nerve biopsy specimens from patients with vasculitic and other inflammatory and non-inflammatory neuropathies, and ..
  60. ncbi A mouse model of sural nerve injury-induced neuropathy: gabapentin inhibits pain-related behaviors and the hyperactivity of wide-dynamic range neurons in the dorsal horn
    Yu Omori
    Department of Applied Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani, Toyama, Japan
    J Pharmacol Sci 109:532-9. 2009
    ..b>Sural nerve ligation did not affect motor function of the affected hind paw, but tibial and common peroneal nerve ligation ..
  61. ncbi Evidence of changes in sural nerve conduction mediated by light emitting diode irradiation
    Elke Vinck
    Department of Rehabilitation Sciences and Physiotherapy, Ghent University, 9000 Ghent, Belgium
    Lasers Med Sci 20:35-40. 2005
    ..A randomised controlled study was conducted by measuring antidromic nerve conduction on the peripheral sural nerve of healthy subjects (n=64)...
  62. ncbi Ultrasound improves the success rate of a sural nerve block at the ankle
    Kirsten E Redborg
    Departments of Anesthesiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Reg Anesth Pain Med 34:24-8. 2009
    During ankle block performance, anesthetizing the sural nerve is important for generating complete anesthesia of the lateral aspect of the foot...
  63. ncbi Aldose reductase inhibition by AS-3201 in sural nerve from patients with diabetic sensorimotor polyneuropathy
    Vera Bril
    Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes Care 27:2369-75. 2004
    ..of this investigation was to determine whether AS-3201, a new aldose reductase inhibitor, penetrates the sural nerve and inhibits sorbitol and fructose accumulation in patients with diabetic sensorimotor polyneuropathy (DSP)...
  64. ncbi Sural nerve pathology in diabetic patients with minimal but progressive neuropathy
    R A Malik
    Department of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
    Diabetologia 48:578-85. 2005
    The early pathological features of human diabetic neuropathy are not clearly defined. Therefore we quantified nerve fibre and microvascular pathology in sural nerve biopsies from diabetic patients with minimal neuropathy.
  65. ncbi A novel strategy for repairing preganglionic cervical root avulsion in brachial plexus injury by sural nerve grafting
    Jau Ching Wu
    Department of Neurosurgery, Taipei Veterans General Hospital, Taipei, Taiwan
    J Neurosurg 110:775-85. 2009
    ....
  66. ncbi A morphometric study on the longitudinal and lateral symmetry of the sural nerve in mature and aging female rats
    André Jeronimo
    Department of Biological Sciences, Federal University of Triangulo Mineiro, Uberaba, Minas Gerais, Brazil
    Brain Res 1222:51-60. 2008
    ..We investigated morphological and morphometric aspects of the sural nerve in aging rats...
  67. ncbi Long-term effects of ranirestat (AS-3201) on peripheral nerve function in patients with diabetic sensorimotor polyneuropathy
    Vera Bril
    Department of Medicine, University of Toronto, Canada
    Diabetes Care 29:68-72. 2006
    ..We aimed to determine whether ranirestat, an aldose reductase inhibitor, maintains the improved nerve function observed in patients with diabetic sensorimotor polyneuropathy (DSP) after completing a 12-week nerve biopsy study...
  68. pmc The relative contributions of the medial sural and peroneal communicating nerves to the sural nerve
    Chang Hwan Kim
    Department of Physical Medicine and Rehabilitation, Inha University Hospital, Jung Gu, Inchon 400 711, Korea
    Yonsei Med J 47:415-22. 2006
    ..medial sural cutaneous nerve (MSCN) and peroneal communicating nerve (PCN) conjoin in the calf area to form the sural nerve (SN)...
  69. ncbi Dysmyelinating sensory-motor neuropathy in merosin-deficient congenital muscular dystrophy
    A Di Muzio
    Center for Neuromuscular Diseases, University G D Annunzio, Chieti, Italy
    Muscle Nerve 27:500-6. 2003
    ..Thus, in congenital muscular dystrophy, merosin expression may be dissociated in different tissues, and the neuropathy is sensory-motor and due to abnormal myelinogenesis...
  70. ncbi Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy
    Vera Bril
    Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Diabetes Care 25:2048-52. 2002
    ..to determine the validity of the Toronto Clinical Scoring System (CSS) in reflecting the presence and severity of diabetic peripheral sensorimotor polyneuropathy (DSP) as determined by myelinated fiber density (FD) on sural nerve biopsy.
  71. pmc Axonal phenotype of Charcot-Marie-Tooth disease associated with a mutation in the myelin protein zero gene
    F Chapon
    Laboratoire de Neuropathologie, Centre Hospitalier Universitaire de Caen, 14033 Caen, France
    J Neurol Neurosurg Psychiatry 66:779-82. 1999
    ..One of the patients, presently 30 years old, showed only Argyll Robertson-like pupils as an objective sign but no clinical or electrophysiological signs of peripheral neuropathy...
  72. ncbi Sural nerve fibre pathology in diabetic patients with mild neuropathy: relationship to pain, quantitative sensory testing and peripheral nerve electrophysiology
    R A Malik
    University Department of Medicine, Manchester Royal Infirmary, Oxford Road, M13 9WL, UK
    Acta Neuropathol 101:367-74. 2001
    ..b>Sural nerve myelinated and unmyelinated fibre pathology was morphometrically quantified and related to the presence of pain ..
  73. ncbi The Thr124Met mutation in the peripheral myelin protein zero (MPZ) gene is associated with a clinically distinct Charcot-Marie-Tooth phenotype
    P De Jonghe
    Department of Biochemistry, Flanders Interuniversity Institute for Biotechnology VIB, University of Antwerp UIA, University Hospital Antwerpen UZA, Belgium
    Brain 122:281-90. 1999
    ..Clusters of remyelinating axons in a sural nerve biopsy demonstrate an axonal involvement, with axonal regeneration...
  74. ncbi Neurophysiological and ultrasound findings in sural nerve lesions following stripping of the small saphenous vein
    S Simonetti
    Division of Neurology, E O Ospedali Galliera, Mura delle Cappuccine 14, I 16128 Genoa, Italy
    Muscle Nerve 22:1724-6. 1999
    We describe the neurophysiological and ultrasound (US) findings in two patients with right sural nerve lesions following stripping of the small saphenous vein for varicose vein treatment...
  75. ncbi Anatomy of the sural nerve and its relation to the Achilles tendon
    J Webb
    Department of Trauma and Orthopedic Surgery, North Bristol NHS Trust, Southmead Hospital, UK
    Foot Ankle Int 21:475-7. 2000
    b>Sural nerve injury is a complication of Achilles Tendon (TA) rupture. We dissected 30 cadaveric lower limbs to describe the course of the sural nerve in relation to the TA...
  76. pmc Diagnostic value of sural nerve biopsy in chronic inflammatory demyelinating polyneuropathy
    D S Molenaar
    Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 64:84-9. 1998
    To investigate the additional diagnostic value of sural nerve biopsy of 64 patients in whom chronic inflammatory demyelinating polyneuropathy (CIDP) was considered, as sural nerve biopsy is recommended in the research criteria of an ad ..
  77. ncbi Epidermal nerve fiber density and sural nerve morphometry in peripheral neuropathies
    D N Herrmann
    Department of Neurology, University of Rochester, NY 14642, USA
    Neurology 53:1634-40. 1999
    To study intraepidermal nerve fiber (IENF) density in distal leg skin biopsies, sural nerve morphometry, electrophysiology, and clinical features in patients with peripheral neuropathies.
  78. ncbi Early myelin breakdown following sural nerve crush: a freeze-fracture study
    A M Martinez
    Departamento de Histologia e Embriologia, Instituto de Ciencias Biomedicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil
    Braz J Med Biol Res 33:1477-82. 2000
    ..These alterations are compatible with a direct injury to the myelin sheath following nerve crush. The results are discussed in terms of a similar mechanism underlying both axon and myelin breakdown...
  79. ncbi Diagnostic and therapeutic value due to suspected diagnosis, long-term complications, and indication for sural nerve biopsy
    Albert Ruth
    Department of Neurosurgery, University of Regensburg, Franz Josef Strauss Allee 11, D 93042 Regensburg, Germany
    Clin Neurol Neurosurg 107:214-7. 2005
    In order to elicit the usefulness of sural nerve biopsy we retrospectively evaluated the courses of disease of every patient, who underwent this procedure in our department between January 1995 and March 2000...
  80. ncbi Sural nerve harvest: anatomy and technique
    Berish Strauch
    Department of Plastic and Reconstructive Surgery, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA
    J Reconstr Microsurg 21:133-6. 2005
    A minimally-invasive technique of sural nerve harvesting using an initial blunt tip harvesting device, combined with a recessed sharp cutting mechanism for final severance of the nerve, has been developed...
  81. ncbi Subjective outcomes following sural nerve harvest
    Michael Miloro
    Oral and Maxillofacial Surgery, University of Nebraska Medical Center, Omaha, NE 68198 5180, USA
    J Oral Maxillofac Surg 63:1150-4. 2005
    The goal of this study was to assess subjective patient recovery of donor site sensory deficit following sural nerve harvest for trigeminal nerve repair surgery.
  82. ncbi Origin and make up of the human sural nerve
    H Mestdagh
    Laboratoire d'Anatomie, , Place de Verdun, F-59045 Lille, France
    Surg Radiol Anat 23:307-12. 2001
    The dissection of 37 cadavers has shown that in only a third of cases, the sural nerve comes from the communication between the medial cutaneous nerve, derived from the tibial nerve, and the communicating branch of the lateral cutaneous ..
  83. ncbi Transperineurial arterioles in human sural nerve
    J Beggs
    Division of Neuropathology, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013
    J Neuropathol Exp Neurol 50:704-18. 1991
    ..Axon varicosities exhibit a variety of morphologically distinct vesicles including dense-cored and a diversity of agranular vesicles. These findings suggest that TPA play a role in the neurogenic control of endoneurial blood flow...
  84. ncbi Sural and saphenous 14-cm antidromic sensory nerve conduction studies
    Ralph M Buschbacher
    Indiana University, Indianapolis, Indiana, USA
    Am J Phys Med Rehabil 82:421-6. 2003
    ..To create a large database of normal values for the sural and saphenous nerve conduction studies and to compare the results for the two nerves...
  85. ncbi Anatomical variations of the sural nerve
    Pasuk Mahakkanukrauh
    Department of Anatomy, Faculty of Medicine, Chiangmai University, Chiangmai, Thailand 50200
    Clin Anat 15:263-6. 2002
    An anatomical study of the formation of the sural nerve (SN) was carried out on 76 Thai cadavers. The results revealed that 67...
  86. pmc Late onset axonal Charcot-Marie-Tooth phenotype caused by a novel myelin protein zero mutation
    H M E Bienfait
    Department of Neurology, Academic Medical Centre, University of Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:534-7. 2006
    ..The primary axonal disease process in these patients points to a function of MPZ in maintenance of the myelinated axons, apart from securing stability of the myelin layer...
  87. ncbi "Double whammy" neuropathy: a 37-year-old woman with burning and weakness in both legs
    Simon J Hickman
    Department of Neurology, The National Hospital for Neurology and Neurosurgery, London, UK
    Lancet Neurol 5:632-6. 2006
  88. ncbi [Histopathological features of biopsied peroneus brevis muscle in patients with peripheral neuropathies]
    Mariko Yamashita
    Department of Neurology, Osaka Saiseikai Nakatsu Hospital, 2 10 39 Shibata, Kita ku, Osaka 530 0012, Japan
    No To Shinkei 55:1033-9. 2003
    ..milder in the PB muscles of CIDP patients and more marked in those showing definite axonal degeneration in the sural nerve. The severity of the neuropathic changes in the PB muscles, however, did not necessarily correlate with the ..
  89. ncbi Electrophysiology of small peripheral nerve fibers in man. A study using the cutaneous silent period
    Jovita Svilpauskaite
    Department of Neurology, Kaunas University of Medicine, Lithuania
    Medicina (Kaunas) 42:300-13. 2006
    ..The cutaneous silent period (CuSP), a transient suppression of electromyographic voluntary activity that follows painful stimuli, could serve as an objective functional measure of the A delta fibers...
  90. ncbi Use of an intact sensory nerve to bridge a motor nerve defect: an experimental study
    Serçin Tirelioğlu
    Department of Plastic and Reconstructive Surgery, Anatomy, and Physiology, Faculty of Medicine, Uludag University, Bursa, Turkey
    J Neurosurg 104:804-9. 2006
    ..The goal of this study was to identify the source of the regenerating axons...
  91. ncbi Phenotypic and cellular expression of two novel connexin32 mutations causing CMT1X
    K A Kleopa
    Department of Clinical Neurosciences, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
    Neurology 66:396-402. 2006
    ..To determine the phenotypic and cellular expression of two novel connexin32 (Cx32) mutations causing X-linked Charcot-Marie-Tooth disease (CMT1X)...
  92. ncbi Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial
    P Kaufmann
    Department of Neurology, Columbia University, New York 10032, USA
    Neurology 66:324-30. 2006
    ..To evaluate the efficacy of dichloroacetate (DCA) in the treatment of mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS)...
  93. ncbi Peripheral neuropathy in genetic mitochondrial diseases
    David E Stickler
    Department of Neurology, University of Florida, Gainesville, Florida, USA
    Pediatr Neurol 34:127-31. 2006
    ....
  94. ncbi Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients
    Hania S Kassem
    Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Neuro Endocrinol Lett 26:775-9. 2005
    ..In this study we intended to find a correlation between hypertriglyceridemia and peripheral neuropathy (PN) in patients with a high triglyceride level and no neurological complaints...
  95. ncbi Chronic sensory neuronopathy associated with human T-cell lymphotropic virus type I infection
    Rie Shimazaki
    Third Department of Internal Medicine, Oita Medical University, Hasama 1 1, 879 5593, Oita, Japan
    J Neurol Sci 194:55-8. 2002
    ..A sural nerve specimen revealed severe degeneration of myelinated and unmyelinated axons...
  96. ncbi Clinicopathologic features of nonsystemic vasculitic neuropathy and microscopic polyangiitis-associated neuropathy: a comparative study
    M Sugiura
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Neurol Sci 241:31-7. 2006
    ..To compare clinicopathologic findings in nonsystemic vasculitic neuropathy (NSVN) and microscopic polyangiitis-associated neuropathy (MPAN)...
  97. ncbi The effect of height on paclitaxel nerve damage
    Harry Openshaw
    Department of Neurology, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010 3000, USA
    J Neurooncol 74:207-10. 2005
    ..Nerve length is probably one of these factors. To determine whether the effect of height is clinically important would require additional study with a larger number of subjects and longer clinical follow-up...
  98. ncbi Reversible multifocal conduction block in sarcoid neuropathy
    Chieko Suzuki
    J Peripher Nerv Syst 11:93-5. 2006
  99. ncbi Thalidomide neuropathy in patients treated for metastatic prostate cancer
    F M Molloy
    EMG Section, National Institute of Neurological Disorders and Stroke (NINDS, 10 Center Drive, MSC 1404, Bethesda, Maryland 20892-1404, USA
    Muscle Nerve 24:1050-7. 2001
    ..Older age and cumulative dose were possible contributing factors. Neuropathy may thus be a common complication of thalidomide in older patients. The SNAP index can be used to monitor peripheral neuropathy, but not for early detection...
  100. ncbi Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial
    Irina A Anselm
    Neurology 67:1313; author reply 1313. 2006
  101. ncbi [Clinical characteristics of Cuban epidemic neuropathy]
    N Gómez-Viera
    Hospital Clinico Quirurgico Hermanos Ameijeiras, La Habana, Cuba
    Rev Neurol 25:1848-52. 1997
    ..At the beginning of 1992 an epidemic neuropathy was seen in Cuba...

Research Grants49

  1. Bioengineered scaffolds for peripheral nerve repair
    Ravi V Bellamkonda; Fiscal Year: 2010
    ..The clinical "gold standard" for bridging peripheral nerve gaps is autografts (typically using sensory sural nerve), where 40~50% of patients regain useful function...
  2. Biomarkers in Diabetic Neuropathy
    EVA LUCILLE FELDMAN; Fiscal Year: 2010
    ..DN and measure its progression include nerve conduction studies, quantitative sensory measures and decreased sural nerve myelinated fiber density (MFD)...
  3. Mechanisms of HIV-Induced PNS Disease: The SIV Macaque Model
    Joseph Mankowski; Fiscal Year: 2009
    ..inflammation of the dorsal root ganglia with abundant replication of SIV in macrophages and neuronal loss, sural nerve inflammation, and reduction in the number of epidermal nerve fibers in the feet...
  4. Rho GTPases and Neuroprotection Model in Cancer Therapy
    Qun Lu; Fiscal Year: 2012
    ..inhibitor CCG-1423) combinations enhance anti-cancer efficacy while reducing CIPN (measured by improving sural nerve conduction and touch sensation) in immunocompetent mice inoculated with syngeneic Lewis Lung carcinoma cells...
  5. OPTIC NEUROPATHY FROM MITOCHONDRIAL DERANGEMENT
    Alfredo Sadun; Fiscal Year: 1999
    ..given the investigator unparalleled access to examine patients and obtain tissues (150 sera and CSF samples, sural nerve biopsies, and an eye with optic nerve all secured at the height of the epidemic) from CEON patients...
  6. Supraspinal Modulation of Neuropathic Pain
    Bradley Taylor; Fiscal Year: 2007
    ..develops following transection of the tibial and common peroneal branches of the sciatic nerve, leaving the sural nerve intact...
  7. MYELOPATHY AND NEUROPATHY DURING CHANGING HIV BURDEN
    Benjamin Gelman; Fiscal Year: 2004
    ..AIM 3 will approach the problem retrospectively using a unique asset. We archived fresh spinal cord and sural nerve specimens over a period of 13 years spanning from the pre-AZT, pre-neurotoxic, pre-protease inhibitor, and the ..
  8. NON-INVASIVE SURROGATE MARKERS FOR DIABETIC NEUROPATHY
    Andrew Boulton; Fiscal Year: 2004
    ..Moreover, subjects who have either recently undergone or are planned to undergo fascicular sural nerve biopsy will also have assessment of corneal nerve morphology and the p75NTR titre to define their exact ..
  9. Neurophysiological mechanisms underlying spasms in SCI
    Maria Knikou; Fiscal Year: 2004
    ..A future study can be concentrated on the potential reflex pathways underlying spasms and their relation to hip extension (end of stance phase) during assisted locomotion in incomplete SCI patients. ..
  10. ENDOTHELIAL DYSFUNCTION IN HUMAN DIABETIC NEUROPATHY
    CHARLENE HAFER MACKO; Fiscal Year: 2002
    ....
  11. MOLECULAR BASIS OF HEREDITARY NEURALGIC AMYOTROPHY
    PHILLIP CHANCE; Fiscal Year: 2008
    ..Moreover, characterization of the HNA gene may have broader pathophysiological and therapeutic implications for more common idiopathic forms of brachial neuropathy. [unreadable] [unreadable]..
  12. 2007 International Peripheral Nerve Society Meeting at Snowbird, Utah
    A Smith; Fiscal Year: 2007
    ..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
  13. Identification and characterization of the ALS4 gene
    PHILLIP CHANCE; Fiscal Year: 2006
    ..Specific Aim (5) is to develop an animal model of ALS4 by introducing an identified disease-causing mutation into the germline of the mouse by employing either transgenesis or gene targeting. ..
  14. DIABETIC NEUROPATHY STUDY
    PETER DYCK; Fiscal Year: 2008
    ..abstract_text> ..
  15. Oxidative Stress and Nerve Pathology in Diabetes
    Andrew Mizisin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  16. Standards of Scientific Conduct
    Michael Kalichman; Fiscal Year: 2008
    ..Effective teaching about standards of the [unreadable] responsible conduct of research will help to promote public health by fostering integrity in the conduct of biomedical research. [unreadable] [unreadable] [unreadable]..
  17. Multi-Joint Sensorimotor Dysfunction of the Stroke Arm
    BRIAN SCHMIT; Fiscal Year: 2008
    ..In addition, conventional therapies may be applied more efficiently or effectively using the principles that will be demonstrated by this study. ..
  18. HEARING DEFICIT DUE TO AUDITORY NEUROPATHY
    Arnold Starr; Fiscal Year: 2009
    ..The results of our studies could have major impact on the diagnosis, classification, understanding, and treatment of auditory neuropathy. ..
  19. SPINAL MOTOR CONDUCTION AND RECOVERY AFTER HUMAN SCI
    Blair Calancie; Fiscal Year: 2009
    ..A slow-release formulation the K-channel blocker 4-aminopyridine will be tested for its effects on conduction in some cases. ..
  20. Reducing Risk Factors in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ....
  21. Reflex Regulation of Motor function in Human SCI
    BRIAN D contact SCHMIT; Fiscal Year: 2010
    ..This study has important implications for therapies aimed at restoring movement in SCI and for the treatment of spasticity to improve functional movements. ..
  22. Exercise-based Motivational Interviewing for Fibromyalgia
    DENNIS CHUA ANG; Fiscal Year: 2010
    ..Furthermore, if proven efficacious, Ml could readily be applied to other chronically painful conditions (e.g. chronic back pain). ..
  23. HYPERTENSION, RISK FOR HYPERTENSION AND HYPOALGESIA
    Christopher France; Fiscal Year: 2003
    ..Three studies are proposed that will use the nociceptive flexion reflex (NFR), defined as the intensity of sural nerve stimulation required to elicit leg withdrawal, as an objective measure of nociception...
  24. Magnetic Resonance in Peripheral Arterial Disease
    Mary Mcgrae McDermott; Fiscal Year: 2010
    ..This knowledge, in subsequent studies, is expected to lead to new therapies for PAD-related functional impairment and functional decline. ..
  25. Peptidergic Neurotransmission in the Spinal Cord
    VIRGINIA SEYBOLD; Fiscal Year: 2009
    ..If the hypothesis is proven to be true, the data will provide evidence for a new therapeutic strategy that may be effective in treating peripheral inflammatory diseases. ..
  26. Preventing Adverse Reactions in Novice Blood Donors
    Christopher R France; Fiscal Year: 2010
    ..Because we are working directly with the American Red Cross, our findings can be quickly translated into practice. ..
  27. In-Vivo Confocal Imaging of Meissner's Corpuscles as a Measure of HIV Neuropathy
    David Herrmann; Fiscal Year: 2008
    ..In-vivo RCM of MCs may prove to have wide application for early identification of sensory peripheral neuropathies, and to assess effectiveness of therapy. [unreadable] [unreadable] [unreadable]..
  28. Inflammation and Peripheral Arterial Disease Outcomes
    Mary McDermott; Fiscal Year: 2008
    ..Results will be used to develop interventions to improve functioning and prevent functional decline in PAD. ..
  29. INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION
    Roger Madison; Fiscal Year: 2007
    ..Many collaborations for translational studies are formed at this symposium. [unreadable] [unreadable] [unreadable]..
  30. SENSORY NEURON ADDITION IN RAT
    PAUL FAREL; Fiscal Year: 2002
    ..We will also determine whether the presumed population of type-L neurons differs from nature sensory neurons in the functional differentiation. ..
  31. IGFS MEDIATE MOTILITY IN HUMAN NEUROBLASTOMA CELLS
    Eva Feldman; Fiscal Year: 2002
    ..Clearly, anti-growth factory therapy, targeted at specific genes, has both theoretical and practical appear in the treatment of NBL. ..
  32. INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION
    Roger Madison; Fiscal Year: 2003
    ..This format has been very successful during the previous eight symposia. ..
  33. BODY WEIGHT SUPPORTED AMBULATION TRAINING AFTER SCI
    Blair Calancie; Fiscal Year: 2004
    ..abstract_text> ..
  34. BLOOD FACTORS AND PERIPHERAL ARTERIAL DISEASE OUTCOMES
    Mary McDermott; Fiscal Year: 2004
    ....
  35. ROLE OF INTERNEURONAL CIRCUITS IN HUMAN SPINAL CORD INJU
    BRIAN SCHMIT; Fiscal Year: 2004
    ..The principles developed in this study will form the basis for new treatment modalities for spasticity in spinal cord injury. ..
  36. GLUCOTOXICITY MEDIATES APOPTOSIS IN DIABETIC NEUROPATHY
    Eva Feldman; Fiscal Year: 2005
    ..Use genetically altered mice to characterize the death pathway in clinical diabetic neuropathy and determine the point of IGF-I protection ..
  37. TRAINING IN CLINICAL RESEARCH ETHICS
    Michael Kalichman; Fiscal Year: 2005
    ....
  38. Mechanisms of Disability in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2005
    ..Results will be used to develop interventions designed to improve lower extremity functioning and prevent functional decline in persons with PAD. ..
  39. Neurophysiological Changes in Mild Cognitive Impairment
    Arnold Starr; Fiscal Year: 2005
    ..Experimental findings may also have clinical applications for determining the risk of conversion from MCI to Alzheimer's disease in individual MCI patients, and could provide objective measures of treatment efficacy. ..
  40. INTERNATIONAL SYMPOSIUM ON NEURAL REGENERATION
    Roger Madison; Fiscal Year: 2005
    ..This format has been very successful during the previous ten symposia. ..
  41. Epidermal Innervation as an Outcome Measure
    David Herrmann; Fiscal Year: 2006
    ..measures which include: a) a patient generated pain scale; b) quantitative sensory testing; c) sural nerve conduction; and d) autonomic function. Dr...
  42. ETHNIC DISPARITY IN THE USE OF JOINT ARTHROPLASTY
    DENNIS ANG; Fiscal Year: 2007
    ..The Program Director, Munro Peacock, M.D., was appointed in July 1987. The GCRC was ..
  43. The Manahattan HIV Brain Bank
    Susan Morgello; Fiscal Year: 2007
    ....
  44. Surgical Management of Facial Nerve Injury
    Theresa Hadlock; Fiscal Year: 2007
    ..The academic environment is one of complete dedication to advancing both biomedical science and patient care through careful study and diligent investigation, and of support for the mentored investigator. [unreadable] [unreadable]..
  45. HYPOGLYCEMIA AND AUTONOMIC NERVOUS SYSTEM FUNCTION
    Roy Freeman; Fiscal Year: 2007
    ..Thus, the broad long term objectives of the proposal are to fully understand the mechanisms and consequences of hypoglycemia associated autonomic failure with the ultimate goal of finding an efficacious treatment. ..
  46. Improving Functioning in Peripheral Arterial Disease
    Mary McDermott; Fiscal Year: 2007
    ..By identifying the optimal exercise program for improving functioning in PAD patients with and without IC, our findings will have substantial clinical and public health implications for millions of patients with PAD. ..
  47. PERIPHERAL ARTERIAL DISEASE AND FUNCTIONAL OUTCOMES
    Mary McDermott; Fiscal Year: 2001
    ..They further state that the results of this study will be used to develop subsequent intervention studies designed to improve quality of life and prevent functional decline among men and women with PAD. ..