tibial nerve

Summary

Summary: The medial terminal branch of the sciatic nerve. The tibial nerve fibers originate in lumbar and sacral spinal segments (L4 to S2). They supply motor and sensory innervation to parts of the calf and foot.

Top Publications

  1. ncbi Functional recovery and histomorphometric assessment following tibial nerve injury in the mouse
    Laura T George
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Reconstr Microsurg 19:41-8. 2003
  2. ncbi Neuromodulative treatment with percutaneous tibial nerve stimulation for intractable detrusor instability: outcomes following a shortened 6-week protocol
    Wai Yoong
    Department of Obstetrics and Gynaecology, North Middlesex University Hospital, London, UK
    BJU Int 106:1673-6. 2010
  3. ncbi Recovery of electromyographic activity after transection and surgical repair of the rat sciatic nerve
    Arthur W English
    Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Room 405P, Atlanta, GA 30322, USA
    J Neurophysiol 97:1127-34. 2007
  4. ncbi Evaluation of asymptomatic central neuropathy in type I diabetes mellitus
    N Uzun
    Istanbul University, Cerrahpasa Medical Faculty, Neurology Department
    Electromyogr Clin Neurophysiol 46:131-7. 2006
  5. ncbi On the methods employed to record and measure the human soleus H-reflex
    Maria Knikou
    Department of Rehabilitation Medicine, Staten Island University Hospital, Staten Island, NY 10314, USA
    Somatosens Mot Res 23:55-62. 2006
  6. ncbi Long-term durability of percutaneous tibial nerve stimulation for the treatment of overactive bladder
    Scott A MacDiarmid
    Alliance Urology Specialists, Greensboro, North Carolina 27403, USA
    J Urol 183:234-40. 2010
  7. ncbi Percutaneous tibial nerve stimulation effects on detrusor overactivity incontinence are not due to a placebo effect: a randomized, double-blind, placebo controlled trial
    Enrico Finazzi-Agrò
    Department of Surgery Urology, Tor Vergata University, Rome, Italy
    J Urol 184:2001-6. 2010
  8. ncbi Randomized trial of percutaneous tibial nerve stimulation versus extended-release tolterodine: results from the overactive bladder innovative therapy trial
    Kenneth M Peters
    William Beaumont Hospital, Royal Oak, Michigan, USA
    J Urol 182:1055-61. 2009
  9. ncbi Morphological and functional changes in the diabetic peripheral nerve: using diagnostic ultrasound and neurosensory testing to select candidates for nerve decompression
    Doohi Lee
    Texas Diagnostic Imaging PA, Plano, TX, USA
    J Am Podiatr Med Assoc 95:433-7. 2005
  10. ncbi Percutaneous tibial nerve stimulation for the treatment of urinary frequency, urinary urgency, and urge incontinence: results from a community-based clinic
    Leslie Saltzstein Wooldridge
    Bladder Control Clinic, Mercy Health Partners at the Lakes, Muskegon, MI, USA
    Urol Nurs 29:177-85. 2009

Research Grants

Detail Information

Publications225 found, 100 shown here

  1. ncbi Functional recovery and histomorphometric assessment following tibial nerve injury in the mouse
    Laura T George
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Reconstr Microsurg 19:41-8. 2003
    ..Injury to the tibial nerve offers several advantages to sciatic nerve injury, including improved lower extremity sensation and end-organ ..
  2. ncbi Neuromodulative treatment with percutaneous tibial nerve stimulation for intractable detrusor instability: outcomes following a shortened 6-week protocol
    Wai Yoong
    Department of Obstetrics and Gynaecology, North Middlesex University Hospital, London, UK
    BJU Int 106:1673-6. 2010
    To describe our initial outcome data following a shortened 6-week treatment protocol with percutaneous tibial nerve stimulation (PTNS) in women with overactive bladder syndrome (OABS) unresponsive to bladder retraining and anticholinergic ..
  3. ncbi Recovery of electromyographic activity after transection and surgical repair of the rat sciatic nerve
    Arthur W English
    Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, Room 405P, Atlanta, GA 30322, USA
    J Neurophysiol 97:1127-34. 2007
    ..Spontaneous EMG activity in SOL and GAS and direct muscle (M) responses to posterior tibial nerve stimulation persisted for < or =2 days after sciatic nerve transection, but SOL and GAS H-reflexes ..
  4. ncbi Evaluation of asymptomatic central neuropathy in type I diabetes mellitus
    N Uzun
    Istanbul University, Cerrahpasa Medical Faculty, Neurology Department
    Electromyogr Clin Neurophysiol 46:131-7. 2006
    ....
  5. ncbi On the methods employed to record and measure the human soleus H-reflex
    Maria Knikou
    Department of Rehabilitation Medicine, Staten Island University Hospital, Staten Island, NY 10314, USA
    Somatosens Mot Res 23:55-62. 2006
    ..The ISI refers to the time delay between the single pulses delivered to the posterior tibial nerve within a single trial...
  6. ncbi Long-term durability of percutaneous tibial nerve stimulation for the treatment of overactive bladder
    Scott A MacDiarmid
    Alliance Urology Specialists, Greensboro, North Carolina 27403, USA
    J Urol 183:234-40. 2010
    ..Therapy Trial during phase 1 was a randomized trial demonstrating comparable effectiveness of percutaneous tibial nerve stimulation and extended-release tolterodine during 12 weeks of therapy for frequency, nocturia, urgency, ..
  7. ncbi Percutaneous tibial nerve stimulation effects on detrusor overactivity incontinence are not due to a placebo effect: a randomized, double-blind, placebo controlled trial
    Enrico Finazzi-Agrò
    Department of Surgery Urology, Tor Vergata University, Rome, Italy
    J Urol 184:2001-6. 2010
    This is a prospective, double-blind, placebo controlled study, based on an original placebo technique, performed to evaluate the efficacy of percutaneous tibial nerve stimulation in female patients with detrusor overactivity incontinence.
  8. ncbi Randomized trial of percutaneous tibial nerve stimulation versus extended-release tolterodine: results from the overactive bladder innovative therapy trial
    Kenneth M Peters
    William Beaumont Hospital, Royal Oak, Michigan, USA
    J Urol 182:1055-61. 2009
    ..Therapy trial was a randomized, multicenter, controlled study that compared the effectiveness of percutaneous tibial nerve stimulation to extended-release tolterodine...
  9. ncbi Morphological and functional changes in the diabetic peripheral nerve: using diagnostic ultrasound and neurosensory testing to select candidates for nerve decompression
    Doohi Lee
    Texas Diagnostic Imaging PA, Plano, TX, USA
    J Am Podiatr Med Assoc 95:433-7. 2005
    ..It has further been hypothesized that the tibial nerve in the tarsal tunnel is at risk for chronic nerve compression related to this swelling...
  10. ncbi Percutaneous tibial nerve stimulation for the treatment of urinary frequency, urinary urgency, and urge incontinence: results from a community-based clinic
    Leslie Saltzstein Wooldridge
    Bladder Control Clinic, Mercy Health Partners at the Lakes, Muskegon, MI, USA
    Urol Nurs 29:177-85. 2009
    ..This retrospective analysis evaluated the application of percutaneous tibial nerve stimulation (PTNS), a minimally invasive neuromodulation therapy, in a population of patients who failed to ..
  11. ncbi Generators of tibial nerve somatosensory evoked potential: recorded from the mesial surface of the human brain using subdural electrodes
    Kiyohito Terada
    Department of Neurology, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi ku, Shizuoka, Japan
    J Clin Neurophysiol 26:13-6. 2009
    The generators of the initial cortical component of somatosensory evoked potentials in response to tibial nerve stimulation (Tib-somatosensory evoked potentials) are still uncertain...
  12. ncbi Percutaneous tibial nerve stimulation for the treatment of urge fecal incontinence
    Derek J Boyle
    University of London, London, UK
    Dis Colon Rectum 53:432-7. 2010
    Percutaneous tibial nerve stimulation has been shown to be an effective treatment in patients with urinary disorders, but its benefit in fecal incontinence is uncertain...
  13. ncbi Efficiency of posterior tibial nerve stimulation in category IIIB chronic prostatitis/chronic pelvic pain: a Sham-Controlled Comparative Study
    Sahin Kabay
    Department of Urology, Dumlupinar University Faculty of Medicine, Kutahya, Turkey
    Urol Int 83:33-8. 2009
    To evaluate the efficacy of percutaneous posterior tibial nerve stimulation (PTNS) for treatment of the patients with category IIIB chronic non-bacterial prostatitis/chronic pelvic pain syndrome.
  14. ncbi Evaluation of the use of posterior tibial nerve stimulation for the treatment of fecal incontinence: preliminary results of a prospective study
    Fernando de la Portilla
    Coloproctology Unit, Department of General Surgery, Hospital Juan Ramon Jimenez, Huelva, Spain
    Dis Colon Rectum 52:1427-33. 2009
    ..Intermittent percutaneous tibial nerve stimulation is a new, minimally invasive treatment option for these patients...
  15. ncbi [Posterior tibial nerve stimulation in the management of overactive bladder: a prospective and controlled study]
    Patricia O Bellette
    Servicio de Urologia, Facultad de Medicina, Universidad Estatal de Campinas Unicamp, Brasil
    Actas Urol Esp 33:58-63. 2009
    The aim of this study was to evaluate the efficacy of the Posterior Tibial Nerve stimulation in women with overactivity bladder symptoms and the impact in the quality of life using the Overactivity Bladder Questionnaire (OABq).
  16. ncbi Percutaneous tibial nerve stimulation in the treatment of refractory overactive bladder syndrome: is maintenance treatment necessary?
    Floor van der Pal
    Rijnstate Hospital, Arnhem, The Netherlands
    BJU Int 97:547-50. 2006
    To determine the effect of a pause in percutaneous tibial nerve stimulation (PTNS) in successfully treated patients with an overactive bladder (OAB), and the reproducibility of successful treatment when restored.
  17. ncbi Transcutaneous electrical tibial nerve stimulation in the treatment of fecal incontinence: a randomized trial (CONSORT 1a)
    A M Leroi
    INSERM U1073, Service de Physiologie Digestive, Hopital Charles Nicolle, CHU Rouen, Inserm CIC 0204, Rouen, France
    Am J Gastroenterol 107:1888-96. 2012
    The objective of this study was to show that although transcutaneous electrical tibial nerve stimulation (TENS) is being increasingly used to treat fecal incontinence (FI), its efficacy has never been proved using controlled trials.
  18. pmc Peripheral neuromodulation via posterior tibial nerve stimulation - a potential treatment for faecal incontinence?
    John M Findlay
    Department of Digestive Diseases and Thoracics, Queen s Medical Centre, Nottingham, UK
    Ann R Coll Surg Engl 92:385-90. 2010
    ..Peripheral neuromodulation via posterior tibial nerve stimulation (PTNS) has been assessed in urinary incontinence, but there is minimal evidence for its use in ..
  19. ncbi Scalp distribution of the earliest cortical somatosensory evoked potential to tibial nerve stimulation: proposal of a new recording montage
    M Valeriani
    Department of Neurology, Universita Cattolica del Sacro Cuore, L go A Gemelli 8, 00168 Roma, Italy
    Clin Neurophysiol 111:1469-77. 2000
    To investigate the most reliable method to record the earliest cortical somatosensory evoked potential (SEP) after tibial nerve stimulation. The 'gating' phenomenon was used to dissociate the overlapping cortical SEP components.
  20. ncbi Percutaneous afferent neuromodulation for the refractory overactive bladder: results of a multicenter study
    F E Govier
    Virginia Mason Medical Center, Seattle, Washington, USA
    J Urol 165:1193-8. 2001
    ..Patients received weekly percutaneous electrical stimulations via a 34 gauge needle placed near the tibial nerve 3 finger breadths above the ankle...
  21. ncbi Posterior tibial nerve stimulation in the treatment of voiding dysfunction: urodynamic data
    Vera Vandoninck
    Department of Urology, University Medical Center Nijmegen, PO Box 9101, NL 6500 HB Nijmegen, The Netherlands
    Neurourol Urodyn 23:246-51. 2004
    To determine urodynamic changes and predictive factors in patients with voiding dysfunction who underwent 12 percutaneous tibial nerve stimulations.
  22. ncbi Transcutaneous posterior tibial nerve stimulation for fecal incontinence in inflammatory bowel disease patients: a therapeutic option?
    Veronique Vitton
    Hospices Civils de Lyon, Digestive Physiology, Hopital Edouard Herriot, Lyon, France
    Inflamm Bowel Dis 15:402-5. 2009
    ..Two recent studies showed that transcutaneous posterior tibial nerve stimulation may improve fecal continence...
  23. ncbi Randomized trial of percutaneous tibial nerve stimulation versus Sham efficacy in the treatment of overactive bladder syndrome: results from the SUmiT trial
    Kenneth M Peters
    Department of Urology, Beaumont Hospital, Royal Oak, Michigan 48073, USA
    J Urol 183:1438-43. 2010
    ..SUmiT) was a multicenter, double-blind, randomized, controlled trial comparing the efficacy of percutaneous tibial nerve stimulation to sham through 12 weeks of therapy...
  24. ncbi Alcohol neurolysis of tibial nerve motor branches to the gastrocnemius muscle to treat ankle spasticity in patients with hemiplegic stroke
    Sung Ho Jang
    Department of Physical Medicine and Rehabilitation, Yeungnam University School of Medicine, Taegu, South Korea
    Arch Phys Med Rehabil 85:506-8. 2004
    To evaluate the effectiveness of alcohol neurolysis of tibial nerve motor branches to the gastrocnemius muscle for the treatment of ankle plantarflexor spasticity in patients with hemiplegic stroke.
  25. ncbi Posterior tibial nerve somatosensory cortical evoked potentials in adolescent idiopathic scoliosis
    J C Cheng
    Department of Orthopaedics and Traumatology, Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong
    Spine (Phila Pa 1976) 23:332-7. 1998
    ..SUBJECTS AND METHODS: Posterior tibial nerve somatosensory cortical evoked potentials were evaluated on 147 young patients with adolescent idiopathic ..
  26. ncbi Posterior tibial nerve stimulation for faecal incontinence after partial spinal injury: preliminary report
    B B Mentes
    Department of Surgery, Gazi University Medical School, Besevler 06500 Ankara, Turkey
    Tech Coloproctol 11:115-9. 2007
    This study evaluated the possible effects of posterior tibial nerve stimulation in two patients with faecal incontinence due to partial spinal cord injury.
  27. ncbi Responses of human soleus motor units to low-threshold stimulation of the tibial nerve
    Erdal Binboğa
    Department of Biophysics, Faculty of Medicine, Ege University, Izmir, Turkey
    Exp Brain Res 213:73-86. 2011
    ..Nine men and five women healthy subjects participated in this study. Electrical stimuli were delivered to the tibial nerve in the popliteal fossa...
  28. ncbi Reliability of measuring sciatic and tibial nerve movement with diagnostic ultrasound during a neural mobilisation technique
    Richard Ellis
    Health and Rehabilitation Research Centre, School of Physiotherapy, AUT University, Auckland, New Zealand
    Ultrasound Med Biol 34:1209-16. 2008
    ..39-0.76) compared with excellent (ICC = 0.75) for analysis of longitudinal movement. Diagnostic ultrasound presents a reliable, noninvasive, real-time, in vivo method for analysis of sciatic nerve movement...
  29. ncbi Reliability and size of the measurement error when determining the cross-sectional area of the tibial nerve at the tarsal tunnel with ultrasonography
    Ali M Alshami
    School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Queensland 4072, Australia
    Ultrasound Med Biol 35:1098-102. 2009
    An in depth analysis of the reliability of ultrasonography to measure the cross-sectional area of the tibial nerve or any other peripheral nerve is not available in the literature...
  30. ncbi Insulin receptor in rat peripheral nerve: its localization and alternatively spliced isoforms
    K Sugimoto
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Diabetes Metab Res Rev 16:354-63. 2000
    ..In this study, we investigated the immunolocalization of the insulin receptor (IR) and the expression of its two alternatively spliced isoforms in adult rat peripheral nerve...
  31. ncbi Medial plantar and dorsal sural nerve conduction studies increase the sensitivity in the detection of neuropathy in diabetic patients
    Kayihan Uluc
    Marmara University Hospital, Department of Neurology, Tophanelioglu Cad 13 15 Altunizade, 34640 Istanbul, Turkey
    Clin Neurophysiol 119:880-5. 2008
    ..In the present study, we aimed to evaluate the medial plantar and dorsal sural NCS in a group of diabetic patients with distal sensory neuropathy (DSN) and in healthy controls...
  32. ncbi The clinical and urodynamic results of a 3-month percutaneous posterior tibial nerve stimulation treatment in patients with multiple sclerosis-related neurogenic bladder dysfunction
    Sahin Kabay
    Faculty of Medicine, Department of Urology, Dumlupinar University, Kutahya, Turkey
    Neurourol Urodyn 28:964-8. 2009
    ..The aim of this study was to investigate the effect of PTNS after 12 weeks, on the urodynamic findings in the Multiple Sclerosis (MS) patients with neurogenic detrusor overactivity (NDO)...
  33. ncbi Medial dorsal superficial peroneal nerve studies in patients with polyneuropathy and normal sural responses
    Mark Kushnir
    Department of Neurology, Assaf Harofeh Medical Center, Zerifin 70300, Israel
    Muscle Nerve 31:386-9. 2005
    ..MDSP nerve amplitude, tibial nerve motor velocity, and H reflexes were the most sensitive for detection of mild chronic symmetrical axonal ..
  34. ncbi Urodynamic effect of acute transcutaneous posterior tibial nerve stimulation in overactive bladder
    G Amarenco
    Department of Neurologic Rehabilitation, Urodynamic and Neurophysiology Laboratory, Hopital Rothschild, Assistance Publique Hopitaux de Paris, Paris, France
    J Urol 169:2210-5. 2003
    ..Recently peripheral electrical stimulation of the posterior tibial nerve was proposed for irritative symptoms in first intention or for intractable incontinence...
  35. ncbi Ultrasound improves the success rate of a tibial nerve block at the ankle
    Kirsten E Redborg
    Department of Anesthesiology, Dartmouth Medical School, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Reg Anesth Pain Med 34:256-60. 2009
    The tibial nerve provides the majority of sensation to the foot. Although multiple techniques have been described, there exists little evidence-based medicine evaluating different techniques for blocking the tibial nerve at the ankle...
  36. ncbi Behavioural and anatomical analysis of selective tibial nerve branch transfer to the deep peroneal nerve in the rat
    Stephen W P Kemp
    Department of Clinical Neuroscience, Faculty of Medicine, Hotchkiss Brain Institute, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Eur J Neurosci 31:1074-90. 2010
    ..labelling studies confirmed that the peroneal nerve-innervated muscles were innervated by neurons from the tibial nerve pool in the nerve transfer group...
  37. ncbi Long-term efficacy of percutaneous tibial nerve stimulation for different types of lower urinary tract dysfunction in children
    Maria Luisa Capitanucci
    Department of Nephrology Urology, Children s Hospital Bambino Gesu, Rome, Italy
    J Urol 182:2056-61. 2009
    We evaluated the efficacy of percutaneous tibial nerve stimulation for different types of pediatric lower urinary tract dysfunction.
  38. ncbi Posterior tibial nerve block in the therapeutic management of painful calcaneal spur (plantar fasciitis): a preliminary experience
    Ramasamy Govindarajan
    Can J Anaesth 50:862-3. 2003
  39. ncbi Source generators of the early somatosensory evoked potentials to tibial nerve stimulation: an intracerebral and scalp recording study
    M Valeriani
    Istituto di Neurologia, Universita Cattolica del Sacro Cuore, L go A Gemelli 8, 00168, Rome, Italy
    Clin Neurophysiol 112:1999-2006. 2001
    To investigate the location of the cerebral generators of the early scalp somatosensory evoked potentials (SEPs) after tibial nerve stimulation.
  40. ncbi Percutaneous tibial nerve stimulation in the treatment of overactive bladder: urodynamic data
    Vera Vandoninck
    Department of Urology, University Medical Center Nijmegen, The Netherlands
    Neurourol Urodyn 22:227-32. 2003
    The aim of this study was to evaluate urodynamic changes after percutaneous tibial nerve stimulation (PTNS) for the treatment of complaints related to overactive bladder syndrome and to search for urodynamic-based predictive factors.
  41. ncbi Anatomic site for proximal tibial nerve compression: a cadaver study
    Eric H Williams
    Division of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore MD, USA
    Ann Plast Surg 62:322-5. 2009
    Primary compression of the tibial nerve beneath the fibromuscular sling of the origin of the soleus muscle is rarely discussed in the literature...
  42. ncbi Plantar nerve AP and skin biopsy in sensory neuropathies with normal routine conduction studies
    D N Herrmann
    Department of Neurology, University of Rochester, NY, USA
    Neurology 63:879-85. 2004
    ..To assess the medial plantar nerve action potential (NAP) and skin biopsy in the evaluation of suspected distal sensory neuropathies (SN) with normal routine nerve conduction studies (NCS)...
  43. ncbi Effect of retinoic acid on tibial nerve regeneration after anastomosis in rats: histological and functional analyses
    M O Taha
    Department of Surgery, Universidade Federal de Sao Paulo UNIFESP, Escola Paulista de Medicina EPM, Sao Paulo, Brazil
    Transplant Proc 36:404-8. 2004
  44. ncbi Effects of movement and movement imagery on somatosensory evoked magnetic fields following posterior tibial nerve stimulation
    R Kakigi
    Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Brain Res Cogn Brain Res 5:241-53. 1997
    ..without actual movements) on somatosensory evoked magnetic fields (SEFs) following stimulation of the posterior tibial nerve in normal subjects...
  45. ncbi Percutaneous tibial nerve stimulation as neuromodulative treatment of chronic pelvic pain
    Michael R van Balken
    Department of Urology, University Medical Center Nijmegen, Geert Grooteplein 10, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Eur Urol 43:158-63; discussion 163. 2003
    ..Intermittent Percutaneous Tibial Nerve Stimulation (PTNS) is a new, minimally invasive treatment option, which has shown to significantly decrease ..
  46. ncbi [Oral analgesia versus posterior tibial nerve block for postoperative pain in ambulatory open hallux valgus surgery: a randomized clinical trial]
    C Ferrer Gómez
    Servicio de Anestesiologia y Reanimacion, Hospital Universitari Joan XXIII, Tarragona
    Rev Esp Anestesiol Reanim 53:220-5. 2006
    This trial assessed the safety and efficacy of a continuous posterior tibial nerve block in the ankle provided in the patient's home by elastomeric pump infusion of 0.375% ropivacaine after ambulatory hallux valgus surgery.
  47. ncbi End-to-side nerve grafting of the tibial nerve to bridge a neuroma-in-continuity
    James M Kerns
    Department of Anatomy and Cell Biology, Rush University Medical Center, 600 S Paulina Street, Chicago, IL 60612, USA
    Microsurgery 25:155-64; discussion 164-6. 2005
    ..An 8-mm portion of tibial nerve was resected in 20 rats...
  48. ncbi The central loop of H-reflex in the S1 spinal nerve: normal values and constitutional influencing factors
    M R Ghavanini
    Department of Physical Medicine and Rehabilitation, Shiraz University of Medical Sciences, Shiraz, Iran
    Electromyogr Clin Neurophysiol 41:259-62. 2001
    ..To investigate the central loop of H reflex in the S1 nerve and the constitutional influencing factors in normal healthy individuals...
  49. ncbi Sexual functioning in patients with lower urinary tract dysfunction improves after percutaneous tibial nerve stimulation
    M R van Balken
    Department of Urology, Rijnstate Hospital, Arnhem, The Netherlands
    Int J Impot Res 18:470-5; discussion 476. 2006
    ..e. percutaneous tibial nerve stimulation, PTNS)...
  50. ncbi Dynamic F wave study in patients suffering from peripheral arterial occlusive disease
    A A Argyriou
    EMG Laboratory, Department of Neurology, University of Patras Medical School, Rion Patras, Greece
    Acta Neurol Scand 115:84-9. 2007
    ..To prospectively detect significant transient F wave abnormalities obtained after exercise in patients with peripheral arterial disease (PAD) and to assess the potential diagnostic sensitivity of dynamic F wave study in such a context...
  51. ncbi Pitfalls in the electrodiagnostic studies of sacral plexopathies
    Jinny Tavee
    Naval Medical Center Portsmouth, 620 John Paul Jones Circle, Division of Neurology, Portsmouth, Virgina 23703, USA
    Muscle Nerve 35:725-9. 2007
    ..Findings in the EDX evaluation of SPs are often complex and difficult to localize to a specific site due to multiple complicating factors. Frequently, SPs cannot be diagnosed definitively by EDX assessment alone...
  52. ncbi Effect of rhythmic arm movement on reflexes in the legs: modulation of soleus H-reflexes and somatosensory conditioning
    Alain Frigon
    Neural Control of Human Movement Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurophysiol 91:1516-23. 2004
    ..It is proposed that activation of these networks may assist in reflex linkages between the arms and legs during locomotor tasks...
  53. ncbi [Impact of hypoglycemic episodes on nerves conduction and auditory and visual evoked potentials in children with type 1 diabetes]
    Marta Wysocka-Mincewicz
    Klinika Pediatrii Centrum Zdrowia Dziecka w Warszawie
    Pediatr Endocrinol Diabetes Metab 13:17-22. 2007
    ..The aim of the study was to establish the influence of hypoglycemic moderate and severe episodes on the function of peripheral nerves, hearing and visual pathway...
  54. ncbi Inter-nerves and intra-nerve conduction heterogeneity in CMTX with Arg(15)Gln mutation
    M Capasso
    Neurodegenerative Diseases Unit, Institute of Aging, University G D Annunzio, Ospedale SS Annunziata, Via dei Vestini, I 66013 Chieti, Italy
    Clin Neurophysiol 115:64-70. 2004
    ..We report a CMTX family with a striking heterogeneity of nerve conductions between and within nerves...
  55. ncbi The role of a barrier between two nerve fascicles in adjacency after transection and repair of a peripheral nerve trunk
    Barbara S Lutz
    Department of Plastic Surgery, University Hospital Orebro, Institute for Biomedicine and Surgery, Faculty of Health Sciences, Linkoping, Sweden
    Neurol Res 26:363-70. 2004
    ..Non-vascularized autologous fascia however, reduces also criss-crossing of regenerating axons between the fascicles, but causes significant nerve compression...
  56. ncbi [Subclinical lesions of peripheral nervous system in multiple sclerosis patients]
    Robert Pogorzelski
    Klinika Neurologii Akademia Medyczna w Białymstoku
    Neurol Neurochir Pol 38:257-64. 2004
    ..The aim of our study was to perform an electrophysiological evaluation of the peripheral nervous system in patients with a definite diagnosis of multiple sclerosis and without any clinical signs of peripheral neuropathy...
  57. ncbi Impact of different stimulation types on orthostatic tremor
    J Spiegel
    Department of Neurology, University of the Saarland, Homburg Saar, D 66421 Germany
    Clin Neurophysiol 115:569-75. 2004
    ..Primary orthostatic tremor (OT) is thought to be generated by a unique supraspinal tremor generator. Here we studied the effect of ipsi- and contralateral stimulation of the central and peripheral nervous system on OT...
  58. ncbi Electrophysiologic response recorded in the first dorsal interosseous muscle with stimulation of the tibial and deep fibular nerves
    Kathleen M Galloway
    Department of Physical Therapy, Oakland University, Rochester, Michigan 48309, USA
    Clin Anat 17:312-7. 2004
    ..muscle (FDI) is innervated by the deep branch of the lateral plantar nerve (LPN) from the main trunk of the tibial nerve. Contribution from the deep fibular nerve (DFN) may also play a role in the supply of the FDI...
  59. pmc Parallel facilitatory reflex pathways from the foot and hip to flexors and extensors in the injured human spinal cord
    Maria Knikou
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, and Department of Physical Medicine and Rehabilitation, Feinberg Medical School, Northwestern University, Chicago, IL 60611, USA
    Exp Neurol 206:146-58. 2007
    ..The interactive effects of these sensory signals may be a feature of impaired gait, but when they are appropriately excited, they may contribute to locomotion recovery in these patients...
  60. ncbi Nerve conduction study in Sydenham's chorea
    Francisco Cardoso
    Movement Disorders Clinic, Department of Psychiatry and Neurology, The Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Mov Disord 20:360-3. 2005
    ..Our findings suggest that the possible autoimmune dysfunction in SC patients is not targeted against epitopes present in peripheral nerves...
  61. ncbi [Gunshot injuries of peripheral nervous system: the questions of classification and diagnostics]
    A V Musaev
    Zh Nevrol Psikhiatr Im S S Korsakova 104:10-7. 2004
    ..An evaluation of monosynaptic reflex has a substantial significance for the determination of the level of low extremities injuries...
  62. ncbi Wide-pulse-width, high-frequency neuromuscular stimulation: implications for functional electrical stimulation
    Evan R L Baldwin
    Centre for Neuroscience, E 435 Van Vliet Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2H9
    J Appl Physiol 101:228-40. 2006
    ..as torque increased by 412% after the 100-Hz stimulation, and was more consistent and stable compared with tibial nerve stimulation...
  63. pmc Presynaptic control of group Ia afferents in relation to acquisition of a visuo-motor skill in healthy humans
    Monica A Perez
    Department of Physical Exercise and Sport Science and, Department of Medical Physiology, Panum Institute, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    J Physiol 568:343-54. 2005
    ..Somatosensory evoked potentials (SEPs) evoked by stimulation of the tibial nerve (TN) were also unchanged, suggesting that transmission in ascending pathways was unaltered following the visuo-..
  64. ncbi Estimation of peroneal and tibial afferent activity from a multichannel cuff placed on the sciatic nerve
    Hang Shing Cheng
    Department of Mechanical Engineering, National Cheng Kung University, Tainan, Taiwan
    Muscle Nerve 32:589-99. 2005
    ..The estimation technique provides a powerful tool for in vivo investigation of sensory information transmitted in a peripheral nerve and facilitates implementation of advanced functional neuromuscular stimulation systems...
  65. ncbi Diurnal H-reflex variation in mice
    Jonathan S Carp
    Laboratory of Nervous System Disorders, Wadsworth Center, New York State Department of Health, State University of New York, Albany, NY 12201 0509, USA
    Exp Brain Res 168:517-28. 2006
    ..Six mice were implanted with tibial nerve cuff electrodes and electrodes in the soleus and gastrocnemius muscles, for recording of ongoing and nerve-..
  66. ncbi [Somatosensory evoked potential]
    Satoru Fukuda
    Department of Anesthesiology and Pain Medicine, Faculty of Medical Science, University of Fukui, Fukui 910 1193
    Masui 55:280-93. 2006
    ..For the detection of spinal cord abnormality during operation, posterior tibial nerve stimulation is often used...
  67. ncbi Vitamin B12 deficiency: a clinical and electrophysiological profile
    V Puri
    Department of Neurology, GB Pant Hospital, New Delhi, India
    Electromyogr Clin Neurophysiol 45:273-84. 2005
    ..The present study was conducted to evaluate the clinical and electrophysiological profile of vitamin B12 deficiency syndrome and whether a correlation exists between the disease process and the various electrophysiological parameters...
  68. ncbi Postural uncertainty leads to dynamic control of cutaneous reflexes from the foot during human walking
    Carlos Haridas
    Centre for Neuroscience, University of Alberta, Edmonton, AB, Canada
    Brain Res 1062:48-62. 2005
    ..We argue that the specific adaptation of cutaneous reflexes observed with SP nerve stimulation supports the hypothesis that cutaneous reflexes from the foot contribute to the maintenance of stability during walking...
  69. ncbi Evaluation of the neurosensory function of the medial meniscus in humans
    Baransel Saygi
    PTT Hospital, Department of Orthopaedic Surgery, Istanbul, Turkey
    Arthroscopy 21:1468-72. 2005
    ..The purpose of the study was to investigate whether stimulation of the menisci initiates a cortical response. The reaction of the end organ to the reflex arc is also evaluated...
  70. ncbi Use of an intact sensory nerve to bridge a motor nerve defect: an experimental study
    Serçin Tirelioğlu
    Department of Plastic and Reconstructive Surgery, Anatomy, and Physiology, Faculty of Medicine, Uludag University, Bursa, Turkey
    J Neurosurg 104:804-9. 2006
    ..The goal of this study was to identify the source of the regenerating axons...
  71. ncbi Pulse pressure is independently associated with sensorimotor peripheral neuropathy in patients with type 2 diabetes
    E A Jarmuzewska
    Department of Internal Medicine, Policlinico IRCCS, Ospedale Maggiore, University of Milan, Milan, Italy
    J Intern Med 258:38-44. 2005
    ..e. systolic, SBP; diastolic, DBP; or pulse pressure, PP) is primarily involved. We sought to determine the relationship between BP components and parameters of nerve function in type 2 diabetes...
  72. ncbi Interest of peripheral anesthetic blocks as a diagnosis and prognosis tool in patients with spastic equinus foot: a clinical and electrophysiological study of the effects of block of nerve branches to the triceps surae muscle
    Kevin Buffenoir
    Service de Neurochirurgie, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Clin Neurophysiol 116:1596-600. 2005
    ..To evaluate clinically and electrophysiologically the effects of selective anesthetic blocks of motor nerve branches to the triceps surae muscle on lower limb stretch reflex in patients with spastic equinus foot...
  73. ncbi Long-term physical exercise and somatosensory event-related potentials
    Masako Iwadate
    College of Humanities and Sciences, Nihon University, 3 25 40 Sakurajosui, Setagaya Ku, 156 0045, Tokyo, Japan
    Exp Brain Res 160:528-32. 2005
    ..two oddball tasks following separate somatosensory stimulation at the median nerve (upper-limb task) and at the tibial nerve (lower-limb task)...
  74. ncbi Motor axonal polyneuropathy in the course of ulcerative colitis: a case report
    Zeki Yesilova
    Department of Gastroenterology, Gulhane School of Medicine, Ankara, Turkey
    Turk J Gastroenterol 17:58-61. 2006
    ..Axonal motor polyneuropathy is an unusual extraintestinal manifestation of ulcerative colitis, and is probably associated with an autoimmune process...
  75. ncbi Changes in the centrifugal gating effect on somatosensory evoked potentials depending on the level of contractile force
    T Wasaka
    Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan
    Exp Brain Res 166:118-25. 2005
    ..We recorded SEPs following stimulation of the tibial nerve at the popliteal fossa during the preparatory period of a 20% maximal voluntary contraction (MVC) and 50% MVC...
  76. ncbi Origin of regenerated axons in nerve bypass grafts
    Nobuyuki Tanigawa
    Department of Orthopedic Surgery, Kansai Medical University, Osaka, Japan
    J Neurotrauma 22:605-12. 2005
    ....
  77. pmc The electrophysiological profile of hereditary motor and sensory neuropathy-Lom
    B A Ishpekova
    Department of Medical Neurology, Medical University, Sofia, Bulgaria
    J Neurol Neurosurg Psychiatry 76:875-8. 2005
    ..To make electrophysiological observations on a large kindred with hereditary motor and sensory neuropathy-Lom (HMSN-L) containing 27 affected individuals...
  78. ncbi Hypertriglyceridemia and peripheral neuropathy in neurologically asymptomatic patients
    Hania S Kassem
    Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon
    Neuro Endocrinol Lett 26:775-9. 2005
    ..In this study we intended to find a correlation between hypertriglyceridemia and peripheral neuropathy (PN) in patients with a high triglyceride level and no neurological complaints...
  79. ncbi Subclinical neuromuscular transmission abnormality detected by single-fibre EMG is more pronounced in cluster headache than in migraine with aura
    A Coban
    Department of Neurology, Clinical Neurophysiology and Headache Subunits, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
    Cephalalgia 27:788-92. 2007
    ..The subclinical NMT abnormality shown by SFEMG is more common in CH than in MA. These two primary headache syndromes may have some shared functional abnormality of NMT constituents which is more evident in CH...
  80. pmc A new approach to estimation of the number of central synapse(s) included in the H-reflex
    Mohammadreza Alavian Ghavanini
    Department of Physical Medicine and Rehabilitation, Shiraz Medical School, Zand Avenue, Shiraz, Iran
    BMC Neurol 5:13. 2005
    ..The main goal of this study is the estimation of the H-reflex number of synapse(s) for better understanding of the physiology of this practical reflex...
  81. ncbi Short-latency crossed inhibitory responses in extensor muscles during locomotion in the cat
    Alain Frigon
    Groupe de Recherche sur le Système Nerveux Central, Department of Physiology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    J Neurophysiol 99:989-98. 2008
    ..Short-latency crossed inhibition in ankle extensors appears to be an integral component of cutaneous reflex pathways in intact cats during locomotion, which could be important in synchronizing EMG bursts in muscles of both legs...
  82. ncbi [Evaluation of polyneuropathy severity in chronic renal failure patients on continuous ambulatory peritoneal dialysis or on maintenance hemodialysis]
    Katarzyna Janda
    Katedra i Klinika Nefrologii UJ CM, Krakow
    Przegl Lek 64:423-30. 2007
    ..5 +/- 46.5 months. Both groups were age matched (48.9 +/- 12.4 vs. 50.6 +/- 11.9 yrs; p= NS). Patients with co-existing diseases that could lead to disturbances in nerve conduction were excluded from the study group...
  83. ncbi The effect of autogenous vein grafts on nerve repair with size discrepancy in rats: an electrophysiological and stereological analysis
    Murat Acar
    Department of Plastic, Reconstructive and Aesthetic Surgery, Ondokuz Mayis University School of Medicine, TR 55139 Samsun, Turkey
    Brain Res 1198:171-81. 2008
    ..of nerves were exposed on the hind legs with the nerves cut on the right side, while the proximal stump of the tibial nerve and distal stump of the peroneal nerve were sutured to each other...
  84. ncbi Altered electromyographic activity pattern of rat soleus muscle transposed into the bed of antagonist muscle
    Urszula Slawinska
    Neurophysiology Department, Nencki Institute of Experimental Biology, 02 093 Warsaw, Poland
    J Neurosci 22:5808-12. 2002
    ..Two factors might be responsible for this readjustment: the immaturity of the nervous system at the moment of surgery and preserved afferent innervation of the transposed muscle...
  85. ncbi Reduction of the muscle activity associated with self-imposed electrical stimulation of mixed nerves supplying lower limb muscles in man
    L Gerilovsky
    Institute of Biophysics, Bulgarian Academy of Sciences, Acad G Bontchev Str, Bl 21, 1113 Sofia, Bulgaria
    J Electromyogr Kinesiol 12:247-58. 2002
    ..It is suggested, that in contrast to the classic anticipatory postural adjustments, the anticipatory RMA is presumably an alternative mode of feed-forward control diminishing the undesired effects of the afferent inputs...
  86. ncbi Cardiovascular responses during stimulation of hindlimb skeletal muscle nerves in anaesthetized rats
    Takeshi Ishide
    Department of Cardiovascular Science and Medicine, Chiba University School of Medicine, Chiba, Japan
    Clin Exp Pharmacol Physiol 29:689-95. 2002
    ..Following stimulation of the tibial nerve, blood pressure, heart rate and muscle tension increased by 23 +/- 3 mmHg, 31 +/- 5 b.p.m...
  87. doi Pregabalin-induced cortical negative myoclonus in a patient with neuropathic pain
    Sabine Hellwig
    Epilepsy Behav 13:418-20. 2008
    ..Our findings reveal that even in patients without a history of seizures, pregabalin can cause a cortical negative myoclonus...
  88. ncbi A new concept in the electrophysiological evaluation of syringomyelia
    Florian Roser
    Department of Neurosurgery, University of Tubingen, Germany
    J Neurosurg Spine 8:517-23. 2008
    ..Early-stage syringomyelia is anatomically predisposed to affect decussating spinothalamic fibers that convey pain and sensation primarily. Silent periods have been proven to be a sensitive tool for detecting alterations in this pathway...
  89. ncbi Acute motor conduction block neuropathy pattern occurring in the course of an acute inflammatory demyelinating polyradiculoneuropathy
    J L Fernández-Torre
    Department of Clinical Neurophysiology, University Hospital Marqués de Valdecilla UC and IFIMAV, Avda Valdecilla, s n 39008 Santander, Cantabria, Spain
    Neurophysiol Clin 38:211-6. 2008
    ....
  90. ncbi Abnormalities of somatosensory evoked potentials in konzo--an upper motor neuron disorder
    D Tshala-Katumbay
    Department of Neurology, University Hospital, Kinshasa, Congo
    Clin Neurophysiol 113:10-5. 2002
    ..To determine whether the somatosensory pathways are involved or not in konzo...
  91. pmc Group I projections from intrinsic foot muscles to motoneurones of leg and thigh muscles in humans
    P Marque
    Neurophysiologie Clinique, , , 47 boulevard de l'Hpital, 75651 Paris Cedex 13, France
    J Physiol 536:313-27. 2001
    ..lateralis (VL), semitendinosus (ST) and biceps (Bi) were studied after electrical stimuli applied to: (i) the tibial nerve (TN) at ankle level, (ii) the corresponding homonymous nerve, and (iii) the skin of the heel, to mimic the TN-..
  92. ncbi New aspects of clinical pathology and electro-physiological muscle disturbances in patients with history of trichinellosis
    W Kociecka
    Clinic of Parasitic and Tropical Diseases, KMUMS, Przybyszewskiego 49, Poznan, Poland
    Parasite 8:S173-5. 2001
    ..These observations illustrate a disturbed function of motor neurones and of impulse transmission at the myoneural junction in patients chronically infected with Trichinella...
  93. ncbi Reinnervation after end-to-side nerve coaptation in a rat model
    Z Zhang
    Department of Orthopaedic Surgery, University of Ioannina School of Medicine, Greece
    Am J Orthop 30:400-6; discussion 407. 2001
    ..The right peroneal nerve was cut and sutured to the tibial nerve in an end-to-side fashion...
  94. ncbi Relationship between electroneurographic changes and serum ubiquitin levels in patients with type 2 diabetes
    E Akarsu
    Department of Endocrinology, Faculty of Medicine, , Erzurum, Turkey
    Diabetes Care 24:100-3. 2001
    ..Further studies are required to confirm this relationship...
  95. ncbi Intersession reliability for H-reflex measurements arising from the soleus, peroneal, and tibialis anterior musculature
    Riann M Palmieri
    Sports Medicine Athletic Training Research Laboratory, Department of Human Services, University of Virginia, Charlottesville, Virginia 22904, USA
    Int J Neurosci 112:841-50. 2002
    ..This protocol allows the clinician/researcher to reliably investigate the alpha motoneuron excitability of multiple motoneuron pools about the ankle at a single point in time...
  96. ncbi Electrophysiological evaluation of genito-sphincteric dysfunction in multiple system atrophy
    A Pellegrinetti
    Department of Neuroscience, Section of Neurology, University of Pisa, Pisa, Italy
    Int J Neurosci 113:1353-69. 2003
    ..Even if diagnostic yield is not improved using these investigations they provide evidence of multiple lesion sites other than Onuf's nucleus...
  97. ncbi Evaluation of atrophy of foot muscles in diabetic neuropathy -- a comparative study of nerve conduction studies and ultrasonography
    Kaare Severinsen
    Department of Neurology, Aarhus University Hospital, 8000 Aarhus C, Denmark
    Clin Neurophysiol 118:2172-5. 2007
    ..To evaluate the relation between the findings at nerve conduction studies and the size of small foot muscles determined by ultrasonography...
  98. ncbi Facioscapulohumeral muscular dystrophy. Multimodal evoked potentials and electroretinogram
    J P Stübgen
    Department of Neurology, University of Pretoria, South Africa
    Electromyogr Clin Neurophysiol 47:233-41. 2007
    ..Clinical or subclinical abnormalities of the central nervous system (CNS) have been reported in a range of primary muscle diseases, including the muscular dystrophies...
  99. ncbi Correlation of vibratory quantitative sensory testing and nerve conduction studies in patients with diabetes
    John C Kincaid
    Department of Neurology, Indiana University, Indianapolis, Indiana, USA
    Muscle Nerve 36:821-7. 2007
    ..189 to 0.480 (Pearson correlation coefficients, P < 0.001). The low to moderate correlation between QST and NCS suggests that these tests cannot replace each other but are complementary...
  100. ncbi Reference values for peroneal nerve motor conduction to the tibialis anterior and for peroneal vs. tibial latencies
    Ralph M Buschbacher
    Department of Physical Medicine and Rehabilitation, Indiana University, Indianapolis 46202, USA
    Am J Phys Med Rehabil 82:296-301. 2003
    ..To generate a large normative database for the peroneal study to the tibialis anterior and to analyze differences between the peroneal latency to the extensor digitorum brevis and the tibial latency to the abductor hallucis...
  101. ncbi Diabetic neuropathy and surface sway-referencing disrupt somatosensory information for postural stability in stance
    Fay B Horak
    Neurological Sciences Institute, Oregon Health and Science University, Portland, Oregon, USA
    Somatosens Mot Res 19:316-26. 2002
    ....

Research Grants44

  1. Neuro-Musculoskeletal Plasticity after SCI
    Richard K Shields; Fiscal Year: 2010
    ..The proposed method not only has excellent potential for efficacy, but is also likely to be economical and easily integrated into the daily lives of people with SCI. ..
  2. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..toe spread significantly recovered after transplantation of hair-follicle bulge cells between the severed tibial nerve indicating the transplanted mice recovered the ability to walk normally...
  3. Beaumont Interstitial Cystitis Clinical Research Network
    Kenneth Peters; Fiscal Year: 2007
    ..Adverse events and complications will be monitored. Ancillary studies as agreed upon by the ICCRN will be carried out in conjunction with the clinical trial. ..
  4. Efficacy of Hypothermia in Pediatric TBI
    P David Adelson; Fiscal Year: 2004
    ..Parallel clinical specific aims will define the effect of neurotransmitter release in response to treatment with HYPO and the age-related impact of HYPO on early and delayed cell death in children. ..
  5. HYPOTHERMIA FOR SEVERE TBI IN CHILDREN
    P David Adelson; Fiscal Year: 2004
    ....
  6. CARDIOPULMONARY MODULATION OF SPINAL PAIN TRANSMISSION
    Alan Randich; Fiscal Year: 1990
    ..range") and class 3 ("nociceptive specific") neurons of the lumbar spinal dorsal horn activated by either tibial nerve stimulation (A-fiber and A- and C-fiber intensities) or noxious heat stimulation applied to the plantar surface ..
  7. CARDIOVASCULAR/PAIN - REGULATORY SYSTEM INTERACTIONS
    Alan Randich; Fiscal Year: 1993
    ..electrophysiological recordings of responses of class 2 and class 3 lumbar spinal dorsal horn neurons to either tibial nerve stimulation (A- and C-fiber intensities) or noxious heating of the foot during either electrical stimulation or ..
  8. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  9. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  10. Neurophysiological mechanisms underlying spasms in SCI
    Maria Knikou; Fiscal Year: 2004
    ..A future study can be concentrated on the potential reflex pathways underlying spasms and their relation to hip extension (end of stance phase) during assisted locomotion in incomplete SCI patients. ..
  11. SPINAL MOTOR CONDUCTION AND RECOVERY AFTER HUMAN SCI
    Blair Calancie; Fiscal Year: 2009
    ..A slow-release formulation the K-channel blocker 4-aminopyridine will be tested for its effects on conduction in some cases. ..
  12. BODY WEIGHT SUPPORTED AMBULATION TRAINING AFTER SCI
    Blair Calancie; Fiscal Year: 2004
    ..abstract_text> ..
  13. STIMULUS-SPECIFIC SI CORTICOCORTICAL INTERACTIONS
    Barry Whitsel; Fiscal Year: 2007
    ..abstract_text> ..
  14. MUSCULOSKELETAL PLASTICITY AFTER SPINAL CORD INJURY
    RICHARD SHIELDS; Fiscal Year: 2003
    ..The benefits of this newly developed adaptive feedback controlled exercise may provide a standard that individuals with paralysis may use in an effort to maintain their musculoskeletal properties following paralysis. ..
  15. MUSCLE FUNCTION IN HUMAN CERVICAL SPINAL CORD INJURY
    Christine Thomas; Fiscal Year: 2007
    ..The information obtained will also provide a rationale for the design of new rehabilitation that will aim to dampen involuntary muscle activity or to use it effectively to perform functional tasks. ..
  16. DIABETIC NEUROPATHY STUDY
    PETER DYCK; Fiscal Year: 2008
    ..abstract_text> ..
  17. Targeted tumoricidal bacteria
    Ming Zhao; Fiscal Year: 2007
    ..Future human trials of the tumor-killing bacteria can be held after the Phase I and Phase II grant periods are completed. [unreadable] [unreadable] [unreadable]..
  18. Physical Activity and Quality of Life in Multiple Sclerosis
    Robert Motl; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. Assessment of Penile Autonomic Innervation
    Claire Yang; Fiscal Year: 2007
    ..The ability to detect cavernous neuropathy is relevant to the evaluation of erectile dysfunction, as well as the development of disease-specific treatments for neurogenic erectile dysfunction. [unreadable] [unreadable]..
  20. Electromechanical Stimuli on the Development of Engineered Myotendinous Junction
    Lisa Larkin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. RESCUE OF DENERVATED MUSCLE
    Christine Thomas; Fiscal Year: 2007
    ..Equally important, reinnervation may maintain muscle tissue, making it more receptive to renewed neural activity established by regeneration of peripheral or central axons. ..
  22. RHOMOCYCSTEINASE FOR HOMOCYSTEINE ASSAY
    Yuying Tan; Fiscal Year: 2002
    ..The tHCY enzymatic kits for these applications will be ready for commercial launch at this point. PROPOSED COMMERCIAL APPLICATION: Not Available ..
  23. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  24. Imageable tumor-targeting bacteria
    Ming Zhao; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  25. DONOR SPECIFIC IMMUNOSUPPRESSION TO TRACHEAL ALLOGRAFTS
    Eric Genden; Fiscal Year: 2004
    ..Specific Aim II will focus on alternative methods of inducing donor specific tolerance to tracheal allografts. Specific Aim III will focus on the behavior of the tracheal allograft and its affect upon the established state of tolerance. ..
  26. MUSCLE FUNCTION IN HUMAN CERVICAL SPINAL CORD INJURY
    Christine K Thomas; Fiscal Year: 2010
    ..Analysis of whether exercise and/or anti-spasm medication reduces involuntary contractions will clarify whether the treatments currently used to control unwanted muscle contractions need revision. ..
  27. Discovery of novel fluorescent reporter genes
    Ming Zhao; Fiscal Year: 2004
    ..Reporters with spectral properties that can be used for whole-body imaging of tumors in the lung and their metastases will be candidates for further development for numerous applications of multi-color imaging. ..
  28. ACUTE REPAIR OF SPINAL INJURY WITH FUSOGENS
    Richard Borgens; Fiscal Year: 2002
    ..An anatomical evaluation of the degree of axonal repair between control and PEG treated spinal cords using a horseradish peroxidase dye exclusion test and conventional histology. ..
  29. Cognitive Function After Intracranial Aneurysm Surgery
    Satwant Samra; Fiscal Year: 2005
    ..Information gained from this investigation will be important in giving a prognosis for returning back to work as well as planning rehabilitation of patients suffering from aneurysmal SAH in future. ..
  30. THE CPA: SOMATIC AND AUTONOMIC SYSTEMS
    W Panneton; Fiscal Year: 2004
    ..Understanding the brainstem mechanisms governing he vascular constriction after either of these somatic stimuli may provide a neurological explanation for this. Such knowledge may lead to an understanding of essential hypertension. ..
  31. Treatment of Persistent Postprostatectomy Incontinence
    Patricia Goode; Fiscal Year: 2007
    ..abstract_text> ..
  32. Adenoviral GFP targeting of metastatic human tumors using multiple delivery route
    Hiroyuki Kishimoto; Fiscal Year: 2008
    ..Having obtained these results, we can move forward in the Phase II grant application with experiments to bring OBP-401 to the clinic for use in cancer surgery in human patients. [unreadable] [unreadable] [unreadable]..
  33. Inhibitors of 5alpha-reductase for acne therapy
    Lingna Li; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATIONS: Liposomal 4-MA will be developed as a topical selectively targeted therapeutic for acne for which they should be a very market. ..
  34. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  35. Orthotopic models of tumor angiogenesis and blood flow
    Meng Yang; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  36. Neurite density in skin as a marker for neuropathic pain
    Anne Louise Oaklander; Fiscal Year: 2005
    ..abstract_text> ..
  37. Dual-color tumor-host imaging models
    Meng Yang; Fiscal Year: 2007
    ..These models have significant commercial potential for discovery and development of stroma-targeted and anti-angiogenesis drugs. [unreadable] [unreadable] [unreadable]..
  38. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  39. Enzyme therapy for hyperhomocysteinemia
    Yuying Tan; Fiscal Year: 2005
    ..Phase II results will lead to an IND for MEGC-PEG-rMETase for end stage renal disease patients and other patients with intractable hyperhomocysteinemia and high cardiovascular disease mortality. ..
  40. REGULATION OF MASTICATORY MUSCLE FIBER PHENOTYPE
    ARTHUR ENGLISH; Fiscal Year: 2002
    ..The new knowledge generated will impact significantly several areas of clinical dentistry. ..
  41. Proteoglycan degradation and functional recovery after peripheral nerve injury
    ARTHUR ENGLISH; Fiscal Year: 2007
    ..This proposal seeks to evaluate a technology for medical treatment of peripheral nerve injuries which, if successful, could have an important impact on a relatively large group of under-treated patients. [unreadable] [unreadable]..
  42. AXONAL GROWTH IN THE CHRONICALLY INJURED SPINAL CORD
    JOHN HOULE; Fiscal Year: 2003
    ..abstract_text> ..
  43. In-Vivo Confocal Imaging of Meissner's Corpuscles as a Measure of HIV Neuropathy
    David Herrmann; Fiscal Year: 2008
    ..In-vivo RCM of MCs may prove to have wide application for early identification of sensory peripheral neuropathies, and to assess effectiveness of therapy. [unreadable] [unreadable] [unreadable]..
  44. Epidermal Innervation as an Outcome Measure
    David Herrmann; Fiscal Year: 2006
    ..Dr. Herrmann will also examine a method to simplify the analysis of skin biopsy specimens, for easier application in large clinical trials. ..