sciatic nerve

Summary

Summary: A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.

Top Publications

  1. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
  2. ncbi Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve
    Magdalena Bremer
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Erlangen, Germany
    Glia 59:1022-32. 2011
  3. ncbi Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Japan
    J Neurochem 82:1129-36. 2002
  4. pmc Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    TracyAnn Perry
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Room 2C13, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Exp Neurol 203:293-301. 2007
  5. pmc Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration
    Poonam Verma
    Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, United Kingdom
    J Neurosci 25:331-42. 2005
  6. ncbi Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells
    M Dezawa
    Department of Anatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004 Japan
    Eur J Neurosci 14:1771-6. 2001
  7. pmc Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
    Hua Sheng Xiao
    Laboratory of Sensory System, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 99:8360-5. 2002
  8. ncbi Gene expression profile in rat dorsal root ganglion following sciatic nerve injury and systemic neurotrophin-3 administration
    Lu Ting Kuo
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Yun Lin branch, No 579, Sec 2, Yun lin Rd, Dou Liou City, Yun Lin County, 640, Taiwan
    J Mol Neurosci 43:503-15. 2011
  9. pmc Soluble neuregulin-1 has bifunctional, concentration-dependent effects on Schwann cell myelination
    Neeraja Syed
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:6122-31. 2010
  10. pmc MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway
    Sharmila Chattopadhyay
    Department of Anesthesiology, University of California, San Diego, California 92093 0629, USA
    Glia 57:1316-25. 2009

Detail Information

Publications317 found, 100 shown here

  1. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
    ..CFA administration induced marked up-regulation of CCR2 mRNA in the skin and a moderate increase in the sciatic nerve and dorsal root ganglia (DRG)...
  2. ncbi Sox10 is required for Schwann-cell homeostasis and myelin maintenance in the adult peripheral nerve
    Magdalena Bremer
    Institut fur Biochemie, Emil Fischer Zentrum, Universitat Erlangen Nurnberg, Erlangen, Germany
    Glia 59:1022-32. 2011
    ..Our report is the first evidence that Sox10 is still essentially required for Schwann-cell function in the adult PNS and establishes a useful model in which to study human peripheral neuropathies...
  3. ncbi Analysis of genes induced in peripheral nerve after axotomy using cDNA microarrays
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Japan
    J Neurochem 82:1129-36. 2002
    ..peripheral nerve regeneration, we analyzed a cDNA library derived from the distal stumps of post-injured sciatic nerve which was enriched in non-myelinating Schwann cells using cDNA microarrays...
  4. pmc Evidence of GLP-1-mediated neuroprotection in an animal model of pyridoxine-induced peripheral sensory neuropathy
    TracyAnn Perry
    Drug Design and Development Section, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Room 2C13, Gerontology Research Center, 5600 Nathan Shock Dr, Baltimore, MD 21224, USA
    Exp Neurol 203:293-301. 2007
    ..Our findings suggest a potential role for these peptides in the treatment of neuropathies, including that associated with type II diabetes mellitus...
  5. pmc Axonal protein synthesis and degradation are necessary for efficient growth cone regeneration
    Poonam Verma
    Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, United Kingdom
    J Neurosci 25:331-42. 2005
    ..Collectively, these findings suggest that local protein synthesis and degradation, controlled by various TOR-, p38 MAPK-, and caspase-dependent pathways, underlie growth cone initiation after axotomy...
  6. ncbi Sciatic nerve regeneration in rats induced by transplantation of in vitro differentiated bone-marrow stromal cells
    M Dezawa
    Department of Anatomy, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, Yokohama, 236 0004 Japan
    Eur J Neurosci 14:1771-6. 2001
    ..The results suggest that MSCs are able to differentiate into myelinating cells, capable of supporting nerve fibre re-growth, and they can therefore be applied to induce nerve regeneration...
  7. pmc Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
    Hua Sheng Xiao
    Laboratory of Sensory System, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 99:8360-5. 2002
    ..Our findings therefore reveal dynamic and complex changes in molecular diversity among DRG neurons after axotomy. Sequences reported in this paper have been deposited in the GenBank database (accession numbers BG 662484-BG 673712)..
  8. ncbi Gene expression profile in rat dorsal root ganglion following sciatic nerve injury and systemic neurotrophin-3 administration
    Lu Ting Kuo
    Division of Neurosurgery, Department of Surgery, National Taiwan University Hospital, Yun Lin branch, No 579, Sec 2, Yun lin Rd, Dou Liou City, Yun Lin County, 640, Taiwan
    J Mol Neurosci 43:503-15. 2011
    Following sciatic nerve transection in adult rats, a proportion of injured dorsal root ganglion (DRG) neurons die, through apoptosis, over the following 6 months...
  9. pmc Soluble neuregulin-1 has bifunctional, concentration-dependent effects on Schwann cell myelination
    Neeraja Syed
    Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:6122-31. 2010
    ..Furthermore, our studies suggest that there may be two distinct steps in Schwann cell myelination: an initial phase dependent on juxtacrine Nrg1 signaling and a later phase that can be promoted by paracrine stimulation...
  10. pmc MMP-9 controls Schwann cell proliferation and phenotypic remodeling via IGF-1 and ErbB receptor-mediated activation of MEK/ERK pathway
    Sharmila Chattopadhyay
    Department of Anesthesiology, University of California, San Diego, California 92093 0629, USA
    Glia 57:1316-25. 2009
    ..We also report on the early changes of MMP-9 mRNA expression (within 24 h) after axotomy. These studies establish that MMP-9 controls critical trophic signal transduction pathways and phenotypic remodeling of Schwann cells...
  11. ncbi Fluorescent nanoparticles for observing primo vascular system along sciatic nerve
    Zhao Feng Jia
    Biomedical Physics Laboratory, Department of Physics and Astronomy, Seoul National University, 599 Gwanak, Gwanak Gu, Seoul, Korea
    J Acupunct Meridian Stud 3:150-5. 2010
    The primo vascular system was found in the epineurium along the rat sciatic nerve following subcutaneous injection of fluorescent nanoparticles at the Zusanli acupoint (ST-36)...
  12. ncbi Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain
    Michael S Gold
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 23:158-66. 2003
    ..8 immunoreactivity along the sciatic nerve. The distribution of Na(V)1...
  13. pmc MicroRNAs modulate Schwann cell response to nerve injury by reinforcing transcriptional silencing of dedifferentiation-related genes
    Andreu Viader
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 31:17358-69. 2011
    ..in SCs are also regulated posttranscriptionally by miRNAs, we performed miRNA expression profiling of mouse sciatic nerve distal segment after crush injury...
  14. ncbi Comparative proteomic profile of rat sciatic nerve and gastrocnemius muscle tissues in ageing by 2-D DIGE
    Daniele Capitanio
    Department of Sciences and Biomedical Technologies, University of Milan, Segrate, MI, Italy
    Proteomics 9:2004-20. 2009
    ..the qualitative and quantitative differences in the proteome and morphology of rat gastrocnemius muscle and sciatic nerve, in healthy 22-month-old rats...
  15. ncbi Dicer in Schwann cells is required for myelination and axonal integrity
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule ETH Zurich, CH 8093 Zurich, Switzerland
    J Neurosci 30:6763-75. 2010
    ..Thus, our data indicate that miRNAs critically regulate Schwann cell gene expression that is required for myelination and to maintain axons via axon-glia interactions...
  16. ncbi The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 55:3335-43. 2006
    ..They also had increased sorbitol pathway activity in the sciatic nerve and increased nitrotyrosine and poly(ADP-ribose) immunofluorescence in the sciatic nerve, spinal cord, and ..
  17. ncbi Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth
    Iris E Bonilla
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:1303-15. 2002
    ..We have used cDNA microarrays to survey those genes induced during successful sciatic nerve regeneration...
  18. ncbi Therapeutic neovascularization using cord blood-derived endothelial progenitor cells for diabetic neuropathy
    Keiko Naruse
    Department of Internal Medicine, Aichi Gakuin University, School of Dentistry 2 11 Suemori dori, Chikusa ku, Nagoya, 464 8651, Japan
    Diabetes 54:1823-8. 2005
    ..into hindlimb skeletal muscles significantly ameliorated impaired sciatic motor nerve conduction velocity and sciatic nerve blood flow in the EPC-injected side of streptozotocin-induced diabetic nude rats compared with the saline-..
  19. pmc Neuroprotective effect of the glucagon-like peptide-1 receptor agonist, synthetic exendin-4, in streptozotocin-induced diabetic rats
    Wei Jing Liu
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, South Korea
    Br J Pharmacol 164:1410-20. 2011
    ..The aim of this study was to investigate the effect of the GLP-1 pathway on peripheral nerves in streptozotocin-induced diabetic rats...
  20. ncbi Periaxin, a novel protein of myelinating Schwann cells with a possible role in axonal ensheathment
    C S Gillespie
    Department of Biological and Molecular Sciences, University of Stirling, Scotland
    Neuron 12:497-508. 1994
    ..first uncompacted whorls of membrane that ensheathe the axon, and further synthesis of the protein in the rat sciatic nerve parallels the deposition of myelin...
  21. ncbi Lumbar transplant of neurons genetically modified to secrete galanin reverse pain-like behaviors after partial sciatic nerve injury
    M J Eaton
    The Miami Project to Cure Paralysis, University of Miami School of Medicine, FL 33136, USA
    J Peripher Nerv Syst 4:245-57. 1999
    ..grafts in a model of chronic neuropathic pain induced by unilateral chronic constriction injury (CCI) of the sciatic nerve. Pain-related behaviors, including cold and tactile allodynia and thermal and mechanical hyperalgesia, were ..
  22. ncbi Effect of NGF and anti-NGF on neuropathic pain in rats following chronic constriction injury of the sciatic nerve
    L S Ro
    Second Department of Neurology, Chang Gung Memorial Hospital and Medical College, Chang Gung University, Taipei, Taiwan
    Pain 79:265-74. 1999
    ....
  23. ncbi The endogenous fatty acid amide, palmitoylethanolamide, has anti-allodynic and anti-hyperalgesic effects in a murine model of neuropathic pain: involvement of CB(1), TRPV1 and PPARgamma receptors and neurotrophic factors
    Barbara Costa
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Italy
    Pain 139:541-50. 2008
    ..PEA was administered i.p. to mice with chronic constriction injury of sciatic nerve (CCI) once a day for one week starting the day after the lesion...
  24. pmc A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool
    A N Garratt
    Max Delbrück Centrum for Molecular Medicine, 13125 Berlin, Germany
    J Cell Biol 148:1035-46. 2000
    ..The thickness of the myelin sheath is determined by the axon diameter, and we suggest that trophic signals provided by the nerve determine the number of times a Schwann cell wraps an axon...
  25. ncbi Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation
    Huarui Zheng
    Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Cancer Cell 13:117-28. 2008
    ..Subsequent degeneration of abnormal Remak bundles was accompanied by initial expansion of nonmyelinating Schwann cells. We suggest abnormally differentiated Remak bundles as a cell of origin for plexiform neurofibroma...
  26. ncbi Spatiotemporal quantification of tumor necrosis factor-alpha and interleukin-10 after crush injury in rat sciatic nerve utilizing immunohistochemistry
    Tomokazu Sawada
    Department of Orthopaedic Surgery, Hamamatsu University School of Medicine, 1 20 1 Handayama, Hamamatsu, Shizuoka 431 3192, Japan
    Neurosci Lett 417:55-60. 2007
    ..immunopositive cells during Wallerian degeneration and the following regeneration after crush injury in rat sciatic nerve using immunohistochemistry and enzyme linked immunosorbent assay (ELISA)...
  27. ncbi Bridging small-gap peripheral nerve defects using biodegradable chitin conduits with cultured schwann and bone marrow stromal cells in rats
    Peixun Zhang
    Department of Orthopaedics and Trauma, Peking University People s Hospital, Beijing, China
    J Reconstr Microsurg 21:565-71. 2005
    ....
  28. pmc MicroRNA-deficient Schwann cells display congenital hypomyelination
    Beth Yun
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 30:7722-8. 2010
    ..In SC differentiation, this is particularly relevant in the key developmental transition from a promyelinating to myelinating SC...
  29. ncbi Histologic analysis of Schwann cell migration and peripheral nerve regeneration in the autogenous venous nerve conduit (AVNC)
    Charles Y Tseng
    Center for Restorative Surgery, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    J Reconstr Microsurg 19:331-40. 2003
    ....
  30. ncbi The effects of electroacupuncture on peripheral nerve regeneration in rats
    Motohiro Inoue
    Meiji University of Oriental Medicine, Kyoto, Japan
    Acupunct Med 21:9-17. 2003
    ..The left sciatic nerve of 55 7-month-old rats was crushed at the thigh...
  31. ncbi Partial sciatic nerve ligation induces increase in the phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun N-terminal kinase (JNK) in astrocytes in the lumbar spinal dorsal horn and the gracile nucleus
    Weiya Ma
    Department of Psychiatry, Douglas Hospital Research Center, McGill University, 6875 Boulevard LaSalle, Verdun, Montreal, Quebec, Canada H4H 1R3
    Pain 99:175-84. 2002
    ..intracellular signal transduction pathway associated with glial cells, which have been activated by partial sciatic nerve ligation (PSNL), a well-characterized rat model of neuropathic pain...
  32. ncbi Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination
    Scott E Leblanc
    Molecular and Cellular Pharmacology Training Program, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurochem 93:737-48. 2005
    ..During myelination of sciatic nerve, there is a very significant induction of SREBP1 and SREBP2, as well as their target genes, suggesting that ..
  33. ncbi Fibrin conduit supplemented with human mesenchymal stem cells and immunosuppressive treatment enhances regeneration after peripheral nerve injury
    Aleksandra M McGrath
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    Neurosci Lett 516:171-6. 2012
    ..of MSC on axonal regeneration in the conduit and reaction of activated macrophages were investigated using sciatic nerve injury model...
  34. ncbi Local anesthetic sciatic nerve block and nerve fiber damage in diabetic rats
    Jeffrey S Kroin
    Department of Anesthesiology, Rush University Medical Center, Chicago, IL 60612, USA
    Reg Anesth Pain Med 35:343-50. 2010
    ..However, it is not clear whether a smaller local anesthetic dose that produces negligible nerve fiber damage in normal rats will produce significant nerve damage in diabetic rats and if adding adjuvant drugs modulates this effect...
  35. ncbi Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    R W Colburn
    Department of Pharmacology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neuroimmunol 79:163-75. 1997
    ..The current findings support the use of bupivacaine as a tool to suppress microglial activation and challenge the putative role of microglia in initiating or potentiating pain behaviors which result from nerve injury...
  36. ncbi Delayed reinnervation by nonpeptidergic nociceptive afferents of the glabrous skin of the rat hindpaw in a neuropathic pain model
    Jennifer C Peleshok
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Comp Neurol 519:49-63. 2011
    ..foot in a well-established rat model of neuropathic pain, namely, the chronic constriction injury (CCI) of the sciatic nerve. We used the immunofluorescence detection of calcitonin gene-related peptide (CGRP), purinergic receptor P2X3, ..
  37. ncbi Nav1.7 accumulates and co-localizes with phosphorylated ERK1/2 within transected axons in early experimental neuromas
    Anna Karin Persson
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Neurol 230:273-9. 2011
    ..7 within axons in neuromas. We demonstrate increased levels of Na(V)1.7 in experimental rat sciatic nerve neuromas, 2weeks after nerve ligation and transaction...
  38. pmc Beneficial effects of exendin-4 on experimental polyneuropathy in diabetic mice
    Tatsuhito Himeno
    Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Diabetes 60:2397-406. 2011
    ..The therapeutic potential of exendin-4, an agonist of the glucagon-like peptide-1 receptor (GLP-1R), on diabetic polyneuropathy (DPN) in streptozotocin (STZ)-induced diabetic mice was investigated...
  39. ncbi Functional recovery after peripheral nerve injury is dependent on the pro-inflammatory cytokines IL-1β and TNF: implications for neuropathic pain
    Sylvain Nadeau
    Centre de recherche du Centre hospitalier de l Université Laval and Department of Molecular Medicine, Universite Laval, Quebec, G1V 4G2, Canada
    J Neurosci 31:12533-42. 2011
    ..we demonstrate that mRNA and protein levels of IL-1β and TNF are rapidly upregulated in the injured mouse sciatic nerve. Mice lacking both IL-1β and TNF, or both IL-1 type 1 receptor (IL-1R1) and TNF type 1 receptor (TNFR1), ..
  40. ncbi Altered sciatic nerve fiber morphology and endoneural microvessels in mouse models relevant for obesity, peripheral diabetic polyneuropathy, and the metabolic syndrome
    Marcin Nowicki
    Institute of Anatomy, University of Leipzig, Leipzig, Germany
    J Neurosci Res 90:122-31. 2012
    ..We conclude that changes in nerve fibers and in endoneural microvessels are present in sciatic nerve of both mouse models of type 2 diabetes...
  41. ncbi miR-221 and miR-222 promote Schwann cell proliferation and migration by targeting LASS2 after sciatic nerve injury
    Bin Yu
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, China
    J Cell Sci 125:2675-83. 2012
    ..Here we report dynamic alteration of miRNA expression following rat sciatic nerve injury using microarray analysis...
  42. ncbi Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination
    Laurent Cotter
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule ETH Zurich, CH 8093 Zurich, Switzerland
    Science 328:1415-8. 2010
    ..Indeed, the Dlg1 brake is no longer functional in a mouse model of Charcot-Marie-Tooth disease. Therefore, negative regulation of myelination appears to be essential for optimization of nerve conduction velocity and myelin maintenance...
  43. pmc Timing in the absence of supraspinal input I: variable, but not fixed, spaced stimulation of the sciatic nerve undermines spinally-mediated instrumental learning
    K M Baumbauer
    Department of Psychology, Texas A and M University, College Station, TX 77843 4325, USA
    Neuroscience 155:1030-47. 2008
    ..The present paper begins to explore these relations by demonstrating that direct stimulation of the sciatic nerve also impairs instrumental learning...
  44. pmc Voluntary exercise increases axonal regeneration from sensory neurons
    Raffaella Molteni
    Department of Neurosurgery, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8473-8. 2004
    ....
  45. ncbi Modulation of P2X receptors via adrenergic pathways in rat dorsal root ganglion neurons after sciatic nerve injury
    Keishi Maruo
    Department of Physiology, Hyogo College of Medicine, Nishinomiya, Japan
    Pain 120:106-12. 2006
    ..examined noradrenaline-induced modulation of ATP-evoked currents in dorsal root ganglion (DRG) neurons after sciatic nerve injury (transection)...
  46. ncbi Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats
    Ajit K Naik
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar
    Eur J Pharmacol 530:59-69. 2006
    ..to examine the role of nitric oxide (NO) in peripheral neuropathy induced by chronic constriction injury of sciatic nerve of rats by using NO precursor, NO donors and nitric oxide synthase (NOS) inhibitors...
  47. ncbi Morphologic and morphometric evaluation of experimental acute crush injuries of the sciatic nerve of rats
    Patrícia Yume Cantalejo Nagima Mazzer
    The Laboratory of Microsurgery, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirao Preto School of Medicine, Sao Paulo University, 14049 900 Ribeirao Preto SP, Brazil
    J Neurosci Methods 173:249-58. 2008
    ..The injury was produced under general anesthesia on a 5mm-long intermediate segment of the right sciatic nerve for 10 min using a dead-weight machine...
  48. ncbi MicroRNAs 144, 145, and 214 are down-regulated in primary neurons responding to sciatic nerve transection
    Hai Ying Zhang
    Department of Anatomy, Hainan Medical College, Haikou 571101, Hainan, China
    Brain Res 1383:62-70. 2011
    ..analysis was performed, and a total of 21 miRNAs were found to be down-regulated following unilateral sciatic nerve transection...
  49. pmc Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase
    Britta J Eickholt
    Medical Research Council Centre for Developmental Neurobiology, King s College London, London, United Kingdom
    PLoS ONE 2:e869. 2007
    ..Our data identify p110delta as an important signaling component for efficient axonal elongation in the developing and regenerating nervous system...
  50. pmc Peripheral nerve injury and TRPV1-expressing primary afferent C-fibers cause opening of the blood-brain barrier
    Simon Beggs
    Program in Neurosciences and Mental Health, Hospital for Sick Children, Department of Physiology, University of Toronto, and University of Toronto Centre for the Study of Pain, Toronto, ON, Canada
    Mol Pain 6:74. 2010
    ..Whether discharge activity of sensory afferents entering the CNS may open the BBB or blood-spinal cord barrier (BSCB) remains an open question...
  51. ncbi Receptor for advanced glycation end products (RAGEs) and experimental diabetic neuropathy
    Cory Toth
    University of Calgary, Department of Clinical Neurosciences, Room 155, 3330 Hospital Dr, N W, Calgary, Alberta T2N 4N1, Canada
    Diabetes 57:1002-17. 2008
    ..We studied experimental diabetic neuropathy and its relationship with RAGE expression using streptozotocin-induced diabetic mice including a RAGE(-/-) cohort exposed to long-term diabetes compared with littermates without diabetes...
  52. ncbi Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury
    S D Novakovic
    Center for Biological Research, Roche Bioscience, Palo Alto, CA 94304 1397, USA
    Pain 80:273-82. 1999
    ..Following a chronic constriction injury to the sciatic nerve, the number of P2X3 positive small and medium diameter neurons increased in dorsal root ganglia when compared ..
  53. ncbi Myelinating Schwann cells determine the internodal localization of Kv1.1, Kv1.2, Kvbeta2, and Caspr
    E J Arroyo
    Department of Neurology, The University of Pennsylvania Medical Center, Pennsylvania, USA
    J Neurocytol 28:333-47. 1999
    ..1 genes. At all of these locations, Caspr and Kv1.1/Kv1.2/Kvbeta2 define distinct but interrelated domains of the axonal membrane that appear to be organized by the myelin sheath...
  54. ncbi Angiotensin II accelerates functional recovery in the rat sciatic nerve in vivo: role of the AT2 receptor and the transcription factor NF-kappaB
    Kirstin Reinecke
    Institute of Pharmacology, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    FASEB J 17:2094-6. 2003
    ..angiotensin II (ANG II) via its AT2 receptor not only promotes regeneration but also functional recovery after sciatic nerve crush in adult rats...
  55. pmc Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes
    Beatriz Duran-Jimenez
    Faculty of Life Sciences, University of Manchester, Manchester, U K
    Diabetes 58:2893-903. 2009
    ..We also investigated the impact of advanced glycation end product (AGE) residue content of ECM on neurite outgrowth from sensory neurons...
  56. ncbi Activation of TRPV1 contributes to morphine tolerance: involvement of the mitogen-activated protein kinase signaling pathway
    Yong Chen
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 28:5836-45. 2008
    ..immunoreactivity (IR) was detected in L4 dorsal root ganglion (DRG) neurons, spinal cord dorsal horn, and sciatic nerve. Real-time reverse transcription (RT)-PCR demonstrated that TRPV1 mRNA was upregulated in spinal cord and ..
  57. ncbi Recombinant human glial growth factor 2 (rhGGF2) improves functional recovery of crushed peripheral nerve (a double-blind study)
    L E Chen
    Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA
    Neurochem Int 33:341-51. 1998
    ..human glial growth factor 2 (rhGGF2), a Schwann cell mitogen, on the recovery of motor function of rat sciatic nerve following crush injury. Seventy three rats were divided into three groups...
  58. ncbi The invulnerability of adult neurons: a critical role for p73
    Gregory S Walsh
    Developmental Biology and Cancer Research, Hospital for Sick Children, Department of Medical Genetics, University of Toronto, Toronto, Ontario, Canada M5G 1X8
    J Neurosci 24:9638-47. 2004
    ..Thus, one way adult neurons become invulnerable is to enhance endogenous survival pathways, and one critical component of these survival pathways is p73...
  59. ncbi Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation
    Jin Qiu
    Wolfson Centre for Age Related Diseases, Guy s, King s, and St Thomas s School of Biomedical Science, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 25:1645-53. 2005
    ..However, if the sciatic nerve is axotomized before injury of the dorsal column, injured axons can regenerate a short distance in the spinal ..
  60. ncbi Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration
    Kazuho Hirata
    Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Microsc Res Tech 57:541-7. 2002
    ..e., opsonin-independent, whereas that of macrophages is mainly opsonin-dependent. It is important to note that SCs and macrophages cooperatively accomplish myelin phagocytosis...
  61. pmc Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 159:361-72. 2002
    ..The presence of these different tight junction proteins in regions of noncompact myelin may be required to maintain the intricate cytoarchitecture of myelinating Schwann cells...
  62. ncbi 'CatWalk' automated quantitative gait analysis as a novel method to assess mechanical allodynia in the rat; a comparison with von Frey testing
    Dorien H Vrinten
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Pain 102:203-9. 2003
    ..We tested rats with a chronic constriction injury of the sciatic nerve, a model of neuropathic pain, both with von Frey filaments and the CatWalk method...
  63. ncbi Differentially promoted peripheral nerve regeneration by grafted Schwann cells over-expressing different FGF-2 isoforms
    Kirsten Haastert
    Department of Neuroanatomy, Hannover Medical School, OE 4140, Carl Neuberg Str 1, 30625 Hannover, Germany
    Neurobiol Dis 21:138-53. 2006
    ..The results contribute to the development of new therapeutic strategies in peripheral nerve repair...
  64. ncbi Peri-sciatic proinflammatory cytokines, reactive oxygen species, and complement induce mirror-image neuropathic pain in rats
    Carin M Twining
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345 Boulder, CO 80309 0345, USA
    Pain 110:299-309. 2004
    ..Here, inflammatory neuropathy is created by injecting an immune activator (zymosan) around one sciatic nerve via an indwelling catheter...
  65. ncbi Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss
    Suzhen Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Neurosci 6:1186-93. 2003
    ..a process that may result from reduced GDNF (glial cell line-derived neurotrophic factor) expression in the sciatic nerve. Neuregulin 1 (NRG1)-ErbB signaling mediates, therefore, reciprocal interactions between non-myelinating ..
  66. ncbi Nociceptive response to innocuous mechanical stimulation is mediated via myelinated afferents and NK-1 receptor activation in a rat model of neuropathic pain
    Graham M Pitcher
    Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
    Exp Neurol 186:173-97. 2004
    ..peripheral neuropathy induced in male Sprague-Dawley rats by placing a 2-mm polyethylene cuff around the left sciatic nerve according to the method of Mosconi and Kruger...
  67. ncbi Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model
    Yeong Ray Wen
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 107:312-21. 2007
    ..Nerve injury-induced ectopic spontaneous activity is essential for the generation of neuropathic pain. The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia...
  68. ncbi Absence of thermal hyperalgesia in serotonin transporter-deficient mice
    Carola Vogel
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurosci 23:708-15. 2003
    ..we investigated 5-HTT-/- mice and compared their pain-related behavior after a unilateral chronic constrictive sciatic nerve injury (CCI) with that of wild-type littermates...
  69. ncbi Conditioning injury-induced spinal axon regeneration fails in interleukin-6 knock-out mice
    William B J Cafferty
    Centre for Neuroscience Research, Guy s, Kings and St Thomas School of Biomedical Science, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 24:4432-43. 2004
    ..In adult mice, conditioning injury to the sciatic nerve 1 week before bilateral dorsal column crush resulted in regeneration of dorsal column axons up to and beyond ..
  70. ncbi Perineural dexmedetomidine provides an increased duration of analgesia to a thermal stimulus when compared with a systemic control in a rat sciatic nerve block
    Chad M Brummett
    Division of Pain Medicine, Department of Anesthesiology, University of Michigan Health System, 1500 E Medical Center Dr, 1H247 UH, Box 0048, Ann Arbor, MI 48109, USA
    Reg Anesth Pain Med 35:427-31. 2010
    ..The present study was designed to test the hypothesis that perineural dexmedetomidine provides a longer duration of analgesia than the same dose given subcutaneously in a peripheral nerve block in rats...
  71. ncbi Dual regeneration of muscle and nerve by intravenous administration of human amniotic fluid-derived mesenchymal stem cells regulated by stromal cell-derived factor-1α in a sciatic nerve injury model
    Dar Yu Yang
    Department of Neurosurgery, Chang Bing Show Chwan Memorial Hospital, Changhua, Taiwan
    J Neurosurg 116:1357-67. 2012
    ..In this study, the authors investigated the feasibility of intravenous administration of AFMSCs according to SDF-1α expression time profiles to facilitate neural regeneration in a sciatic nerve crush injury model.
  72. pmc Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration
    Jung Eun Shin
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 74:1015-22. 2012
    ..These data demonstrate that DLK enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program...
  73. pmc Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain
    Anna K Clark
    Novartis Institutes for BioMedical Research, London WC1E 6BS, United Kingdom
    Proc Natl Acad Sci U S A 104:10655-60. 2007
    ....
  74. pmc Axotomy-induced miR-21 promotes axon growth in adult dorsal root ganglion neurons
    Iain T Strickland
    School of Clinical Sciences, University of Bristol, Bristol, United Kingdom
    PLoS ONE 6:e23423. 2011
    ..changes in a population of small noncoding RNAs known as microRNAs (miRNAs) in the L4 and L5 DRG following sciatic nerve transection...
  75. ncbi Effects of repeated administered ghrelin on chronic constriction injury of the sciatic nerve in rats
    Ensari Guneli
    Department of Laboratory Animal Science, Institute of Health Science, Dokuz Eylul University, 35340 Inciralti, Izmir, Turkey
    Neurosci Lett 479:226-30. 2010
    ..Wistar rats underwent sciatic nerve ligation to induce CCI fallowed by repeated ghrelin administrations (50 and 100microg/kg i.p...
  76. ncbi P0-Cre transgenic mice for inactivation of adhesion molecules in Schwann cells
    M L Feltri
    Department of Neurology, San Raffaele Scientific Institute, Milano, Italy
    Ann N Y Acad Sci 883:116-23. 1999
    ....
  77. ncbi Functional effects of local thyroid hormone administration after sciatic nerve injury in rats
    Ioannis Papakostas
    Pharmacology Department, Medical School of Athens, Athens, Greece
    Microsurgery 29:35-41. 2009
    ..Forty adult male Lewis rats were included in this study. After complete transection of the right sciatic nerve, the gap between the stumps was bridged with a silicone tube...
  78. pmc μ-Conotoxins that differentially block sodium channels NaV1.1 through 1.8 identify those responsible for action potentials in sciatic nerve
    Michael J Wilson
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 108:10302-7. 2011
    ..of the panel was tested on A- and C-compound action potentials recorded from isolated preparations of rat sciatic nerve. The results show that the major subtypes in the corresponding A- and C-fibers were Na(V)1.6 and 1...
  79. ncbi Statin treatment reduces oxidative stress-associated apoptosis of sciatic nerve in diabetes mellitus
    T Gurpinar
    Department of Pharmacology, Celal Bayar University, Faculty of Medicine Manisa, Turkey
    Biotech Histochem 86:373-8. 2011
    ..The aim of our study was to explore the effects of atorvastatin on oxidative stress and apoptosis in the sciatic nerve due to hyperglycemia. Diabetes was induced by streptozotocin...
  80. ncbi Sciatic nerve regeneration by microporous nerve conduits seeded with glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor gene transfected neural stem cells
    Keng Yen Fu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei
    Artif Organs 35:363-72. 2011
    ..promote nerve cell survival and regeneration, but their efficacy in repairing a longer gap defect of rat sciatic nerve (15 mm) has not been established...
  81. ncbi Is the Sciatic Functional Index always reliable and reproducible?
    Vanessa Vilela Monte-Raso
    Orthopedic and Rehabilitation Postgraduation Program, Department of Biomechanics, Medicine and Rehabilitation of the Locomotor Apparatus, Ribeirao Preto School of Medicine, Sao Paulo University, Brazil
    J Neurosci Methods 170:255-61. 2008
    The Sciatic Functional Index (SFI) is a quite useful tool for the evaluation of functional recovery of the sciatic nerve of rats in a number of experimental injuries and treatments...
  82. ncbi The regeneration of transected sciatic nerves of adult rats using chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells
    Qiang Ao
    Department of Physiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, PR China
    Biomaterials 32:787-96. 2011
    ..myelinated axon count, in nerves bridged with BMSC-derived Schwann cells were similar to those treated with sciatic nerve-derived Schwann cells (p > 0...
  83. ncbi Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
    Weiya Ma
    Pain Mechanism Laboratory, Department of Anaesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 15:1037-47. 2002
    ..In the present study, 2 and 4 weeks following partial sciatic nerve ligation (PSNL), we observed a dramatic increase in the prostaglandin synthesizing enzyme cyclooxygenase (COX)..
  84. pmc Locus-wide identification of Egr2/Krox20 regulatory targets in myelin genes
    Sung Wook Jang
    Program in Cellular and Molecular Biology, University of Wisconsin Madison, Madison, Wisconsin 53705, USA
    J Neurochem 115:1409-20. 2010
    ..expression during myelination, we have performed chromatin immunoprecipitation analysis on myelinating rat sciatic nerve in vivo...
  85. pmc Axo-glial interactions regulate the localization of axonal paranodal proteins
    J L Dupree
    Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Cell Biol 147:1145-52. 1999
    ....
  86. ncbi STAT3 phosphorylation in injured axons before sensory and motor neuron nuclei: potential role for STAT3 as a retrograde signaling transcription factor
    Nancy Lee
    Department of Molecular and Cellular Physiology, University of Cincinnati, Cincinnati, Ohio 45267 0576, USA
    J Comp Neurol 474:535-45. 2004
    ..presented here demonstrate that STAT3 is similarly but not identically affected in sciatic motor neurons after sciatic nerve injury...
  87. pmc Sensory nerve innervation of epineurial arterioles of the sciatic nerve containing calcitonin gene-related peptide: effect of streptozotocin-induced diabetes
    M A Yorek
    Department of Internal Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, IA 52246, USA
    Exp Diabesity Res 5:187-93. 2004
    The authors have determined that epineurial arterioles of the sciatic nerve are innervated by nonadrenergic, noncholinergic nerves that contribute to the regulation of vasodilation...
  88. ncbi Methods for the experimental functional assessment of rat sciatic nerve regeneration
    Artur S Varejão
    Department of Pathology and Veterinary Clinics, CETAV, University of Tras os Montes e Alto Douro, P O Box 1013, 5001 911 Vila Real, Portugal
    Neurol Res 26:186-94. 2004
    In experimental peripheral nerve studies, the rat sciatic nerve model is widely used to examine functional changes after different surgical repairs or pharmacological treatments, following nerve injury...
  89. pmc Capsaicin combined with local anesthetics preferentially prolongs sensory/nociceptive block in rat sciatic nerve
    Peter Gerner
    Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Anesthesiology 109:872-8. 2008
    ..05% capsaicin, in a rat sciatic nerve block model.
  90. pmc Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerve
    Lawrence J Coppey
    Veterans Affairs Medical Center, Department of Internal Medicine, University of Iowa, Iowa City 52246, USA
    Int J Exp Diabetes Res 3:21-36. 2002
    ..However, the effect these treatments have on vascular reactivity of epineurial vessels of the sciatic nerve is unknown...
  91. ncbi Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered etanercept into injured and uninjured rat sciatic nerve
    K Kato
    Department of Anesthesiology, University of California, San Diego and the VA Medical Center, 9500 Gilman Drive, La Jolla, CA 92093 0629, USA
    Neuroscience 160:492-500. 2009
    ..and binding specificity for TNF isoforms of locally administered etanercept into injured and uninjured rat sciatic nerve. Distribution and co-localization of etanercept and TNF in the injured and uninjured nerve was evaluated at 1, ..
  92. ncbi Early changes of microRNAs expression in the dorsal root ganglia following rat sciatic nerve transection
    Songlin Zhou
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, JS 226001, PR China
    Neurosci Lett 494:89-93. 2011
    ..Here we report early alterations of miRNAs expression following rat sciatic nerve injury using microarray analysis...
  93. ncbi T lymphocytes play a role in neuropathic pain following peripheral nerve injury in rats
    G Moalem
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267 0521, USA
    Neuroscience 129:767-77. 2004
    ..populations of type 1 and type 2 T cells, with different cytokine secretion profiles, from spleens of sciatic nerve-injured heterozygous rats...
  94. ncbi Macrophage response to peripheral nerve injury: the quantitative contribution of resident and hematogenous macrophages
    Marcus Mueller
    Department of Neurology, Universitatsklinikum Munster, Munster, Germany
    Lab Invest 83:175-85. 2003
    ..After sciatic nerve crush injury, both GFP(-) and GFP(+) resident macrophages, the latter having undergone physiological turnover ..
  95. ncbi Minimal local anaesthetic volumes for sciatic nerve block: evaluation of ED 99 in volunteers
    D Latzke
    Department of Anaesthesia, Intensive Care Medicine and Pain Therapy, Medical University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Br J Anaesth 104:239-44. 2010
    This randomized, double-blinded volunteer study was designed to evaluate the ED(99) volume of local anaesthetic for sciatic nerve blocks using a step-up/step-down methodology.
  96. ncbi Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
    G Wu
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 21:RC140. 2001
    ..Because L4 afferents comingle with degenerating L5 axons in the peripheral nerve, we hypothesize that products associated with Wallerian degeneration lead to an alteration in the properties of the adjacent, uninjured afferents...
  97. ncbi The protective effects of Achyranthes bidentata polypeptides in an experimental model of mouse sciatic nerve crush injury
    Ying Yuan
    Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China
    Brain Res Bull 81:25-32. 2010
    ..We investigated the effects of ABPP administration on peripheral nerve regeneration in a mouse sciatic nerve crush injury model...
  98. ncbi Glial cell responses, complement, and clusterin in the central nervous system following dorsal root transection
    L Liu
    Department of Anatomy, Biomedical Center, Uppsala University, Sweden
    Glia 23:221-38. 1998
    ....
  99. ncbi Leukemia inhibitory factor determines the growth status of injured adult sensory neurons
    W B Cafferty
    Centre for Neuroscience Research, Guy s, King s, and St Thomas School of Biomedical Science, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 21:7161-70. 2001
    ..LIF is also functionally protective to peptidergic sensory neurons after nerve damage in vivo. Our results indicate that the alteration in intrinsic growth status of injured sensory neurons depends, at least in part, on LIF...
  100. pmc Transduced Schwann cells promote axon growth and myelination after spinal cord injury
    Kevin L Golden
    The Miami Project to Cure Paralysis and the Neuroscience Program, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
    Exp Neurol 207:203-17. 2007
    ..These results demonstrate the therapeutic potential for utilizing neurotrophin-transduced SCs to repair the injured spinal cord...
  101. ncbi Preoperative sciatic nerve block decreases mechanical allodynia more in young rats: is preemptive analgesia developmentally modulated?
    Douglas G Ririe
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1009, USA
    Anesth Analg 99:140-5. 2004
    ..In this study, we hypothesized that preoperative sciatic nerve block (SNB), by providing preemptive analgesia, would result in better analgesia than postoperative SNB in the ..

Research Grants63

  1. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ..somatosensory (sciatic nerve) distribution...
  2. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2013
    ..In mice with streptozotocin- induced diabetes, the PI-BMDCs also migrate to and fuse with neurons in the sciatic nerve and dorsal root ganglion (DRG), leading to abnormal nerve function, premature apoptosis of neurons and ..
  3. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..COG112 can significantly prevent axonal degeneration and promote axonal regeneration and remyelination in a sciatic nerve crush model...
  4. Neurotoxicity of Magnetic Nanoparticles
    Veronica Shubayev; Fiscal Year: 2010
    ..In a series of pilot in vivo studies, we used rat sciatic nerve as a combination model for assessment of direct neurotoxicity and effective intraneuronal macrophage ..
  5. Role of 12/15-lipoxygenase in mechanisms of muscle atrophy during aging
    Arunabh Bhattacharya; Fiscal Year: 2013
    ..In Specific Aim 2, the sciatic nerve transection model will be used to determine whether the inhibition of 12/15-LO protects against denervation-..
  6. Molecular, Genetic &Physiological Studies of Calcium-activated Chloride Channels
    Lily Y Jan; Fiscal Year: 2013
    ..specific aim of this proposal is to examine the involvement of TMEM16A in CaCC of DRG neurons with or without sciatic nerve lesion, and to explore potential roles of TMEM16A in pain sensitivity and neuropathic pain, which develops ..
  7. Biomarkers in Diabetic Neuropathy
    EVA LUCILLE FELDMAN; Fiscal Year: 2010
    ..b. Perform cross-species validation between sciatic nerve microarrays from mice with type 2 diabetes and the human sural nerve microarrays in Aim 1a...
  8. Optogenetic inhibition of motor neuron and muscle activity in vivo
    Scott L Delp; Fiscal Year: 2013
    ..Our laboratory has recently reported the first use of optogenetics to excite sciatic nerve motor neurons in transgenic mice...
  9. Genetic analysis of a spontaneous mutation in a rat with a novel hind limb defect
    Debasish Sinha; Fiscal Year: 2010
    ..Histological analysis of frogleg sciatic nerve revealed some abnormal changes in Schwann cells...
  10. Imaging NFkB Activity in Relation to Animal Behavior in Peripheral Neuropathy
    ROBERT D BOWLES; Fiscal Year: 2013
    ..In Aim 1, a model of chronic constriction injury (CCI) of the sciatic nerve will be developed in transgenic mice (NFkB-RE-Luc) containing a luciferase NF-kB reporter...
  11. Profiling and characterizing axonal precursor micro RNAs in regenerating nerve
    Soonmoon Yoo; Fiscal Year: 2013
    ..to profile changes of the precursor and mature miRNA expression levels in the axonal compartments following sciatic nerve injury;(2) To identify the cis-acting region(s) of precursor miRNAs and trans-acting factor(s) that are ..
  12. Mutant human a-synuclein toxicity in mice
    Deborah E Cabin; Fiscal Year: 2012
    ..overexpressed in motor neurons, a-synuclein causes an axonopathy that can be studied in the easily accessible sciatic nerve (Cabin et al. 2005;Giasson et al. 2002;Lee et al...
  13. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ..treatment on Rho-GTPase dependent expression of E-selectin, ICAM-1 and VCAM-1 in primary cultures of rat sciatic nerve endothelial cells and (2) the effect of lovastatin and simvastatin treatment on cell-specific expression of E-..
  14. MicroRNA-29 in postnatal skeletal muscle development and disease
    JASON ROBERT O'ROURKE; Fiscal Year: 2012
    ..progression of muscle atrophy will be monitored in de-nervated wild type and miR-29 mutant mice subjected to sciatic nerve dissection...
  15. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..g.,TNF1);2) application of gp120 to sciatic nerve increases TNF1 in nerve and results in the activation of spinal glia and the pain-related behavior;3) systemic ..
  16. The Regulation of CBF by Adenosine
    H Winn; Fiscal Year: 2009
    ..ADO receptor subtype involved in vasodilation induced by ADO in vitro and during cortical activation evoked by sciatic nerve stimulation (SNS) in vivo;(2) determined that diffusion and counter current mechanisms are not involved in ..
  17. LRP-1 is a multifunctional regulator during peripheral nerve injury and pain.
    Wendy M Campana; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Direct injury to the sciatic nerve and other major nerves in the peripheral nervous system (PNS) may cause chronic neuropathic pain...
  18. Nerve Repair through Muscle Progenitor Cell Transplantation
    Johnny Huard; Fiscal Year: 2013
    ..undergoing in vitro and in vivo neurogenic and glial cell differentiation, and inducing functionl healing of sciatic nerve defects in mice...
  19. Analgesic actions of adenosine A1 receptor along axonal tracts in chronic pain
    Takahiro Takano; Fiscal Year: 2013
    ..adenosine, delivered in the acupoint, potently reduces the conductance of A(delta) and C pain fibers in the sciatic nerve in mice with chronic pain, we propose to evaluate whether A1 receptor signaling in peripheral pain pathways ..
  20. Calcineurin and Neuropathic Pain
    Vjekoslav Miletic; Fiscal Year: 2013
    ..neurons in animals exhibiting neuropathic pain behavior following chronic constriction injury (CCI) of the sciatic nerve or spinal nerve ligation (SNL)...
  21. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2010
    ..Recently we adapted the model of rat endometriosis to involve the sciatic nerve. This model is very similar to the rat endometriosis model where a section of uterus is transplanted to a ..
  22. Cell Cycle Pathway Inhibition Decreases Peripheral Neuropathic Pain
    Junfang Wu; Fiscal Year: 2013
    ..recording, Western blot and immunohistochemical analyses in a mouse model of peripheral nerve injury (partial sciatic nerve ligation), we will test our hypothesis with the following Specific Aims...
  23. Glial-cytokine-neuronal interactions in neuropathic pain
    Han Rong Weng; Fiscal Year: 2012
    ..will be conducted in control (normal naove and sham operated) rats and neuropathic rats induced by partial sciatic nerve ligation, which is known to mimic neuropathic pain induced by partial nerve injury in patients...
  24. HIV and NRTI's-induced painful pathogenic mechanisms and gene therapy
    Shuanglin Hao; Fiscal Year: 2013
    ..The recent development of animal models, created by application of gp120 to the sciatic nerve along with systemic administration of nucleoside reverse transcriptase inhibitors (NRTIs), have allowed ..
  25. Chronic pain and alcohol dependence
    Igor Spigelman; Fiscal Year: 2013
    ..induced by forced chronic intermittent ethanol (CIE) administration, b) peripheral neuropathy induced by sciatic nerve entrapment (SNE) and c) voluntary (2-bottle choice, 2BC) regimen of ethanol (EtOH) consumption...
  26. Pathogenesis of Nerve Injury: Role of Matrix Metalloproteinases
    Veronica Shubayev; Fiscal Year: 2012
    ..as key modulators of neuroimmune activation, demyelination, neuronal death and neuropathic pain after sciatic nerve injury, used as a successful mammalian model of neuronal regeneration...
  27. Mechanisms of cancer cell chemotaxis in perineural invasion
    Richard J Wong; Fiscal Year: 2013
    ..in vitro Matrigel model of PNI that assesses interactions between nerves and cancer cells, an in vivo murine sciatic nerve model of PNI, and studies of surgically resected human cancers...
  28. Sodium Channel Nav1.6 and Pathophysiology of Pain
    Sulayman Dib-Hajj; Fiscal Year: 2012
    ..fibers, consistent with our previous finding of impaired C-fiber compound action potential conduction in sciatic nerve of Nav1.6-null mice. The continued presence of Nav1...
  29. Enhancing Neuroprosthesis Performance with Nerve Cuff Electrodes
    Ronald J Triolo; Fiscal Year: 2010
    ..for standing and stepping after paralysis, 3) design and validate new configurations of the FINE for the human sciatic nerve to control ankle motion, and 4) exploit the fascicular selectivity of these new neural interfaces to extend ..
  30. A novel bioengineered technique to rapidly and permanently repair cut PNS nerves
    GEORGE DAVIS BITTNER; Fiscal Year: 2013
    ..We performance optimize tissue (biocompatability) responses of acutely or chronically excised sciatic nerve segments that are used as inter- position autografts or allografts to PEG-fuse repair acutely or chronically ..
  31. The mechanisms of action of T-lymphocytes in neuropathic pain
    Michael Costigan; Fiscal Year: 2013
    ..phenomenon to perform a whole genome expression screen of the spinal dorsal horns ipsilateral to the injured sciatic nerve from neonates (with no hypersensitivity) and adults (with chronic pain-like symptoms)...
  32. Transplantation of Autologous Schwann Cells for the Repair of Segmental Periphera
    Allan D Levi; Fiscal Year: 2010
    ..autologous Schwann cells suspended in serum with a NeuraGen(R) tube to repair a lengthy gap of the rat sciatic nerve (13 mm)...
  33. Mediators of C-Fiber Response to Partial Nerve Injury
    Beth B Murinson; Fiscal Year: 2010
    ..of neuropathic pain that implants a degenerating nerve segment from an inbred donor over a fenestration in the sciatic nerve of a recipient animal...
  34. Investigating the neuronal physiology of TMEM16A Ca++ activated Cl- channels
    JAMES BERG; Fiscal Year: 2012
    ..At a number of time points following sciatic nerve lesion, the expression of TMEM16a will be examined via quantitative RT-PCR...
  35. Separated-interface Electrodes for use with High Frequency Nerve Conduction Block
    Narendra Bhadra; Fiscal Year: 2013
    ..Acute in vivo studies will be performed on the rat sciatic nerve to evaluate the effectiveness of the SINE in producing a DC nerve conduction block that can be maintained for ..
  36. A Photo-triggered on-demand drug delivery system for chronic pain
    BRIAN PAUL TIMKO; Fiscal Year: 2012
    ..into drug reservoir capsules, and assess the ability of the device to locally deliver anesthesia at the sciatic nerve in a rat model...
  37. Optimizing Peripheral Nerve Regeneration using Computational Intelligence based T
    Xiaojun Yu; Fiscal Year: 2011
    ..predicted by using SWIRL-ANN based analytical and prediction system for bridging peripheral nerve gaps in rat sciatic nerve injury model in vivo...
  38. Thymosin Beta 4 Promotes Recovery of Peripheral Neuropathy in Diabetic Mice
    Lei Wang; Fiscal Year: 2013
    ..In a novel set of experiments, our data show that Tbeta4 remarkably improved sciatic nerve vascular function and peripheral nerve function in diabetic mice, indicating that T[unreadable]4 may have a ..
  39. CA IN MYELIN PRODUCING CELLS
    Ken McCarthy; Fiscal Year: 1993
    ..Cultured Schwann cells isolated from immature and adult sciatic nerve, DRG and sympathetic ganglia will be examined to see whether cells exhibit neuroligand receptors...
  40. NEUROENDOCRINE ETIOLOGY OF DIABETIC GASTROPATHY
    Thomas Nowak; Fiscal Year: 1999
    ..These studies examine the influence of the duration of the diabetic state on vagal and sciatic nerve concentrations of glucose, fructose, sorbitol, myoinositol, and Na+-K+-ATPase activity...
  41. PEPTIDE RELEASE FROM PERIPHERAL TERMINALS OF AFFERENTS
    Tony Yaksh; Fiscal Year: 1991
    ..Specifically, we will examine the SP-LI secretion evoked by antidromic stimulation of the sciatic nerve, with regard to effective stimulus intensity, frequency dependency, apparent relative refractory period; Ca++ ..
  42. Erythropoietin for Neuroregeneration
    John Elfar; Fiscal Year: 2013
    ..systemic erythropoietin (EPO) administration speeds functional recovery after experimental crush injury to the sciatic nerve, even when EPO is administered one week after injury...
  43. Surface Modified Nanofibers for Nerve Regeneration
    JOSEPH COREY; Fiscal Year: 2009
    ..aligned nanofibers will be placed in semipermeable membranes as nerve guides and implanted in rat sciatic nerve gaps...
  44. NERVE REPAIR BY SYNTHETIC AND BIOLOGICAL POLYMERS
    Riyi Shi; Fiscal Year: 2003
    ..adhesive for anastomosing the severed nerve trunks after PEG-fusion of the cell membranes in an isolated sciatic nerve transection model...
  45. Therapeutic hair follicle-derived neurospheres
    Meng Yang; Fiscal Year: 2007
    ..The severed sciatic nerve of C57BL/6 immunocompetent mice was transplanted with ND-GFP cells from the bulge by injection between the two ..
  46. LIPOPROTEIN LIPASE, NUTRITION AND NERVE MYELINATION
    Robert Eckel; Fiscal Year: 2003
    ..Two viral gene delivery systems will be evaluated for their ability to deliver hLPL to rat sciatic nerve: retrovirus-mediated gene delivery, which targets dividing cells, and adenovirus-mediated gene delivery, which ..
  47. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2009
    ..Recently obtained evidence shows that during healing of the transected rat sciatic nerve, contractile fibroblasts organize in a capsule that surrounds the regenerating nerve...
  48. Mechanisms of Motor Neuron Death
    Lee Martin; Fiscal Year: 2006
    ..The profiles of human and mouse ALS MN will be compared to MN induced to degenerate (by sciatic nerve avulsion) through a process that is unequivocally apoptosis and is p53- and Bax-dependent and also involves ..
  49. SCANNING TRANSMISSION ELECTRON MICROSCOPE +XRAY ANALYZER
    Meredith Bond; Fiscal Year: 1990
    ..and other elements: during the cardiac cycle in hamster heart in vivo (Dr Bond), in axonal preparations from sciatic nerve in response to parathyroid hormone stimulation (Dr Breuer) and following exposure to oxidized low density ..
  50. Signal Transduction in Myelinating Cells
    Charles Stiles; Fiscal Year: 2006
    ..biological context to address signaling in myelinated axons is the Wallerian degeneration response of rodent sciatic nerve. In preliminary studies, we have shown that transmembrane receptor tyrosine kinase erbB2 is localized to ..
  51. Prevention of Diabetic Neuropathy with ACE Inhibitors
    Mark Yorek; Fiscal Year: 2007
    ..Previously we demonstrated that in epineurial arterioles of the sciatic nerve acetylcholine-mediated endothelium-dependent vascular relaxation is mediated by nitric oxide (NO) and ..
  52. Remote Viral Gene Delivery in a Mouse Model of ALS
    Bret Mobley; Fiscal Year: 2003
    ..After peripheral injection of vector into either the mouse sciatic nerve or brachial plexus, we will examine the corresponding CNS gene expression...
  53. IN VIVO EXPRESSION OF SCHWANN CELL NA CHANNEL
    GING WANG; Fiscal Year: 1990
    ..The Na channel mRNAs in sciatic nerve will be identified by Northern blot analysis or S1 nuclease mapping using rat brain Na channel cDNA clones...
  54. AXONAL REGENERATION IN SPINAL CORD
    RAYMOND LASEK; Fiscal Year: 1991
    ..cell axons by axonal transport and measure the latency and rate of axonal regeneration in the dorsal root and sciatic nerve. After characterizing the properties of regeneration of the axons in the dorsal root, we will evaluate the ..
  55. VASCULAR DISEASE IN DIABETIC NEUROPATHY
    Mark Yorek; Fiscal Year: 2003
    ..motor nerve conduction velocity (MNCV) and vasorelaxation of arteriole branches that supply circulation to the sciatic nerve. Since nerve ischemia is a primary factor in the development of diabetic neuropathy (DN), understanding the ..
  56. NERVE GROWTH FACTOR PROTECTS SENSORY NEURONS
    Keith Rich; Fiscal Year: 1990
    ..neuronal cell body reaction in rat lumbar dorsal root ganglia (DRG) neurons after ipsilateral axotomy of the sciatic nerve. The influence of the type of lesion and surgical manipulation upon the DRG neuron will be evaluated ..
  57. ALLODYNIC EFFECTS OF SCIATIC INFLAMMATORY NEURITIS
    Linda Watkins; Fiscal Year: 2004
    ..stimuli) induced by immune activation and release of immune cells products in and around one healthy sciatic nerve (sciatic inflammatory neuritis (SIN)...
  58. Molecular probing for the mechanism of neuropathic pain
    Ichiro Nishimura; Fiscal Year: 2006
    ..The Pi's group recently observed that NaV1.8 mRNA is significantly increased in the rat sciatic nerve after sciatic nerve entrapment (SNE) injury but not spinal nerve ligation (SNL) injury...
  59. PLASTICITY AND NEUROPATHOLOGY OF PAIN AND TRANSPLANTS
    Jacqueline Sagen; Fiscal Year: 1999
    ..this work, experiments are proposed using rats with persistent pain due to experimentally-induced arthritis or sciatic nerve constriction...
  60. NEUROPATHIC PAIN FROM AN EXPERIMENTAL NEURITIS
    Gary Bennett; Fiscal Year: 2002
    DESCRIPTION: An experimental inflammation of the rat's sciatic nerve (a neuritis) has been produced by applying Complete Freunds Adjuvant to the surface of the nerve at the mid-thigh level...
  61. Neurorestorative Strategy for Chemotherapy-induced Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2009
    ..mimetics, can significantly prevent axonal degeneration and promote axonal regeneration and remyelination in a sciatic nerve crush model...
  62. ROLE OF INSULIN-LIKE GROWTH FACTORS IN THE PNS
    Eva Feldman; Fiscal Year: 1993
    ..plan to use immunohistochemistry to determine the distribution of IGF-I and II in normal and regenerating rat sciatic nerve. Later, IGF-I and II production sites will be localized with in situ hybridization techniques...
  63. LOCAL ANESTHETIC NEUROTOXICITY IN THE SPINAL CORD
    Michael Kalichman; Fiscal Year: 1991
    ..Using a rat sciatic nerve model, the applicant has demonstrated that local anesthetic-induced peripheral nerve injury is mediated by an ..