spinal nerves

Summary

Summary: The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.

Top Publications

  1. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003
  2. ncbi A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006
  3. ncbi ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 114:149-59. 2005
  4. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
  5. ncbi Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
    G Wu
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 21:RC140. 2001
  6. ncbi Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain
    Michael S Gold
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 23:158-66. 2003
  7. ncbi Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    R W Colburn
    Department of Pharmacology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neuroimmunol 79:163-75. 1997
  8. ncbi Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:3028-38. 2003
  9. ncbi Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats
    Xiu Gao
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 116:62-72. 2005
  10. pmc CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain
    Ling Cao
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Eur J Immunol 38:448-58. 2008

Detail Information

Publications215 found, 100 shown here

  1. ncbi Inhibition of microglial activation attenuates the development but not existing hypersensitivity in a rat model of neuropathy
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Pharmacol Exp Ther 306:624-30. 2003
    ....
  2. ncbi A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance
    Zhi Ye Zhuang
    Department of Anesthesiology, Pain Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 26:3551-60. 2006
    ..Targeting the JNK pathway in spinal astroglia may present a new and efficient way to treat neuropathic pain symptoms...
  3. ncbi ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Pain 114:149-59. 2005
    ..The sequential activation of ERK in dorsal horn microglia and then in astrocytes might reflect distinct roles for these two subtypes of glia in the temporal evolution of neuropathic pain...
  4. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
    ..Coactivation of p38 in DRG neurons and spinal microglia may contribute to later phases of neuropathic pain...
  5. ncbi Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
    G Wu
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 21:RC140. 2001
    ..an L5 dorsal root rhizotomy does not reverse this pain behavior, suggesting that signals from other uninjured spinal nerves are involved. We asked if abnormal activity develops in an adjacent, uninjured root...
  6. ncbi Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain
    Michael S Gold
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 23:158-66. 2003
    ..These observations suggest that aberrant activity in uninjured C-fibers is a necessary component of pain associated with partial nerve injury. They also suggest that blocking Na(V)1.8 would be an effective treatment of neuropathic pain...
  7. ncbi Dissociation of microglial activation and neuropathic pain behaviors following peripheral nerve injury in the rat
    R W Colburn
    Department of Pharmacology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    J Neuroimmunol 79:163-75. 1997
    ..The current findings support the use of bupivacaine as a tool to suppress microglial activation and challenge the putative role of microglia in initiating or potentiating pain behaviors which result from nerve injury...
  8. ncbi Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:3028-38. 2003
    ..We conclude that injured and adjacent uninjured DRG neurons are sensitized to TNF after SNL. Sensitization to endogenous TNF may be essential for the development and maintenance of neuropathic pain...
  9. ncbi Enhancement of NMDA receptor phosphorylation of the spinal dorsal horn and nucleus gracilis neurons in neuropathic rats
    Xiu Gao
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    Pain 116:62-72. 2005
    ..Many pNR1-immunoreactive neurons were identified as projection neurons by retrograde tracer. The data suggest that PKA mediated NMDA receptor phosphorylation plays an important role in spinal nerve ligation induced neuropathic pain...
  10. pmc CNS-infiltrating CD4+ T lymphocytes contribute to murine spinal nerve transection-induced neuropathic pain
    Ling Cao
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Eur J Immunol 38:448-58. 2008
    ..These results strongly support a contributing role of spinal cord-infiltrating CD4(+) T lymphocytes versus peripheral CD4(+) T lymphocytes in the maintenance of nerve injury-induced neuropathic pain...
  11. ncbi Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
    B Shim
    Brain Research Institute, Brain Korea 21 Project for Medical Science, and Department of Physiology, Yonsei University College of Medicine, C P O Box 8044, 120 752, Seoul, South Korea
    Neuroscience 132:193-201. 2005
    ..This nociceptor sensitization can contribute to neuropathic pain...
  12. pmc MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage
    Hideo Kobayashi
    Department of Anesthesiology, University of California, San Diego, CA 92093 0629, USA
    Mol Cell Neurosci 39:619-27. 2008
    ..In conclusion, MMPs mediate the initiation and maintenance of mechanical nociception through Schwann cell-mediated MBP processing and support of neuroinflammation...
  13. ncbi Long-term synaptic plasticity in the spinal dorsal horn and its modulation by electroacupuncture in rats with neuropathic pain
    Guo Gang Xing
    Department of Neurobiology, Key Laboratory for Neuroscience of the Ministry of Education and Public Health, Peking University, 38 Xue Yuan Road, Beijing 100083, People s Republic of China
    Exp Neurol 208:323-32. 2007
    ..LTD of synaptic strength in the spinal dorsal horn in SNL rats may contribute to the long-lasting analgesic effects of EA at 2 Hz...
  14. pmc Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice
    Yun Guan
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 355 Ross, 720 Rutland Ave, Baltimore, Maryland 21205, USA
    Mol Pain 3:29. 2007
    ..Our findings suggest that nNOS, especially in the dorsal root ganglion, may participate in the development and/or maintenance of mechanical hypersensitivity after nerve injury...
  15. ncbi The role of spinal neuroimmune activation in morphine tolerance/hyperalgesia in neuropathic and sham-operated rats
    Vasudeva Raghavendra
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA
    J Neurosci 22:9980-9. 2002
    ..Targeting central cytokine production and glial activation may improve the effectiveness of morphine and reduce the incidence of morphine withdrawal-induced hyperalgesia and allodynia in neuropathic pain conditions...
  16. pmc Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain
    Xiao peng Mei
    Department of Anesthesiology, School of Stomatology, Fourth Military Medical University, Xi an, PR China
    J Neuroinflammation 8:6. 2011
    ..We hypothesized that inhibition of astrocytic JNK activation might be involved in the suppressive effect of ketamine on SNL-induced spinal astrocytic activation...
  17. pmc Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine
    Zhi Ye Zhuang
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Medical Research Building, Boston, MA 02115, USA
    Brain Behav Immun 21:642-51. 2007
    ....
  18. ncbi A peripherally acting Na(v)1.7 sodium channel blocker reverses hyperalgesia and allodynia on rat models of inflammatory and neuropathic pain
    Erin McGowan
    Merck Research Laboratories, Department of Pharmacology and Medicinal Chemistry, Rahway, New Jersey, USA
    Anesth Analg 109:951-8. 2009
    ..7 over Na(v)1.8 and Na(v)1.5...
  19. pmc p38 MAPK, microglial signaling, and neuropathic pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mol Pain 3:33. 2007
    ..Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management...
  20. pmc Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Medical Research Building, Room 604, Boston, Massachusetts 02115, USA
    Nat Med 14:331-6. 2008
    ..Inhibition of MMP may provide a novel therapeutic approach for the treatment of neuropathic pain at different phases...
  21. ncbi The role of uninjured nerve in spinal nerve ligated rats points to an improved animal model of neuropathic pain
    Doo H Lee
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eur J Pain 7:473-9. 2003
    ..As a first set of experiments, in addition to tight ligation of the left L5 and L6 spinal nerves, the intact L4 spinal nerve was manipulated either (1) by gentle repeated stretching of the L4 spinal nerve ..
  22. pmc Critical role of microglial CD40 in the maintenance of mechanical hypersensitivity in a murine model of neuropathic pain
    Ling Cao
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Eur J Immunol 39:3562-9. 2009
    ..These data establish a novel role of microglial CD40 in the maintenance of nerve injury-induced behavioral hypersensitivity, a behavioral sign of neuropathic pain...
  23. ncbi Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study
    Delphine Magis
    Headache Research Unit, Department of Neurology, Liege University, CHR Citadelle, Liege, Belgium
    Lancet Neurol 6:314-21. 2007
    ..Occipital nerve stimulation (ONS) is a new, safe strategy for intractable headaches. We undertook a prospective pilot trial of ONS in drCCH to assess clinical efficacy and pain perception...
  24. pmc Axotomy depletes intracellular calcium stores in primary sensory neurons
    Marcel Rigaud
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
    Anesthesiology 111:381-92. 2009
    ..The authors examined the effect of injury on intracellular Ca stores of the endoplasmic reticulum, which critically regulate the Ca signal and neuronal function...
  25. ncbi Experiments with nitric oxide synthase inhibitors in spinal nerve ligated rats provide no evidence of a role for nitric oxide in neuropathic mechanical allodynia
    Doo H Lee
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neurosci Lett 385:179-83. 2005
    ..NOS), both before and after the induction of mechanical allodynia by tight ligation of the left L5 and L6 spinal nerves in rats (SNL rats)...
  26. ncbi Brain-derived neurotrophic factor increases in the uninjured dorsal root ganglion neurons in selective spinal nerve ligation model
    T Fukuoka
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    J Neurosci 21:4891-900. 2001
    ..These dynamic alterations in the expression and content of BDNF and NGF in the uninjured DRG neurons might be involved in the pathomechanisms of neuropathic pain...
  27. ncbi Activation of p38 mitogen-activated protein kinase in spinal hyperactive microglia contributes to pain hypersensitivity following peripheral nerve injury
    Makoto Tsuda
    Division of Biosignaling, National Institute of Health Sciences, Tokyo, Japan
    Glia 45:89-95. 2004
    ..Taken together, our results demonstrate that nerve injury-induced pain hypersensitivity depends on activation of the p38MAPK signaling pathway in hyperactive microglia in the dorsal horn following peripheral nerve injury...
  28. ncbi Contralateral neuropathic pain and neuropathology in dorsal root ganglion and spinal cord following hemilateral nerve injury in rats
    Satoshi Hatashita
    Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, Japan
    Spine (Phila Pa 1976) 33:1344-51. 2008
    ..The contralateral pain-related behavioral and immunohistochemical changes after hemilateral spinal nerve injury in rats were investigated...
  29. ncbi P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury
    Makoto Tsuda
    Division of Biosignaling, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
    Nature 424:778-83. 2003
    ..Thus, blocking P2X4Rs in microglia might be a new therapeutic strategy for pain induced by nerve injury...
  30. ncbi Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
    ..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation...
  31. pmc The CNS role of Toll-like receptor 4 in innate neuroimmunity and painful neuropathy
    Flobert Y Tanga
    Department of Anesthesiology, Dartmouth Medical School, Lebanon, NH 03756, USA
    Proc Natl Acad Sci U S A 102:5856-61. 2005
    ..Further understanding of this early, specific, innate CNS/microglial response and how it leads to sustained glial/neuronal hypersensitivity may point to new therapies for the prevention and treatment of neuropathic pain syndromes...
  32. ncbi The excitatory effects of the chemokine CCL2 on DRG somata are greater after an injury of the ganglion than after an injury of the spinal or peripheral nerve
    Chang Hui Wang
    Department of Respiratory Medicine, The Tenth People s Hospital of Tongji University, Shanghai 200072, People s Republic of China
    Neurosci Lett 475:48-52. 2010
    ....
  33. ncbi Progesterone receptor antagonist is effective in relieving neuropathic pain
    Daisuke Kondo
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Eur J Pharmacol 541:44-8. 2006
    Injury to the spinal nerves of mice induces allodynia and hyperalgesia. Intrathecal injection of the progesterone/estrogen receptor antagonist ICI 182,780 produced antinociceptive effects...
  34. ncbi Effect of pulsed Nd:YAG laser radiation on action potential conduction in isolated mammalian spinal nerves
    R Orchardson
    Institute of Biomedical and Life Sciences, University of Glasgow, Scotland, United Kingdom
    Lasers Surg Med 21:142-8. 1997
    ..Dental lasers are claimed to produce analgesia, but the mechanisms and extent of any effects are uncertain. This study investigated the effects of lasing on nerve conduction in isolated nerves...
  35. pmc Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity
    Tamara King
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 95724, USA
    Pain 152:1997-2005. 2011
    ....
  36. ncbi A novel spinal action of mexiletine in spinal somatosensory transmission of nerve injured rats
    V Chapman
    Department of Pharmacology, University College London, UK
    Pain 77:289-96. 1998
    ..the spontaneous and peripherally evoked responses of spinal neurones of nerve injured (selective ligation of spinal nerves L5-L6; SNL) rats. Sham controls for the surgical intervention were performed...
  37. ncbi Diagnostic exercise: astrocytoma with involvement of medulla oblongata, spinal cord, and spinal nerves in a raccoon (Procyon lotor)
    A N Hamir
    College of Veterinary Medicine, Oregon State University, Corvallis, OR, USA
    Vet Pathol 45:949-51. 2008
    ..Procyon lotor) with an astrocytoma that involved medulla, cervical spinal cord, and roots of the cervical spinal nerves. Microscopically, the neoplastic cells revealed some pleomorphism but generally had fusiform morphology and ..
  38. pmc Restoration of calcium influx corrects membrane hyperexcitability in injured rat dorsal root ganglion neurons
    Quinn Hogan
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Anesth Analg 107:1045-51. 2008
    ..From this, we predicted that increasing I(Ca) in injured neurons should correct their hyperexcitability...
  39. ncbi Differential action potentials and firing patterns in injured and uninjured small dorsal root ganglion neurons after nerve injury
    Xu Feng Zhang
    Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064, USA
    Brain Res 1009:147-58. 2004
    ....
  40. pmc Changes in expression of sensory organ-specific microRNAs in rat dorsal root ganglia in association with mechanical hypersensitivity induced by spinal nerve ligation
    B T Aldrich
    Department of Anesthesia, University of Iowa, 51 Newton Road, Iowa City, IA 52242, USA
    Neuroscience 164:711-23. 2009
    ..Moreover, SGs were suggested to be assembled and associated with microRNAs after SNL, which may play a role in modification of microRNA-mediated gene regulation in DRG neurons...
  41. pmc Store-operated Ca2+ entry in sensory neurons: functional role and the effect of painful nerve injury
    Geza Gemes
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci 31:3536-49. 2011
    ....
  42. ncbi Painful nerve injury decreases resting cytosolic calcium concentrations in sensory neurons of rats
    Andreas Fuchs
    Department of Anesthesiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Anesthesiology 102:1217-25. 2005
    ..Although cytoplasmic calcium ([Ca]c) critically regulates neuronal function, the effects of peripheral nerve injury on resting sensory neuronal [Ca]c are unknown...
  43. ncbi Characterization of hemangioblastomas of spinal nerves
    Sven Glasker
    Department of Neurosurgery, Albert Ludwigs University, Freiburg, Germany
    Neurosurgery 56:503-9; discussion 503-9. 2005
    ..Peripheral nervous system hemangioblastomas to date have been described only in a few case reports. Experience in treating patients with these rare lesions, which harbor diagnostic and therapeutic pitfalls, is limited...
  44. ncbi Evidence from cadavers suggestive of entrapment of fifth lumbar spinal nerves by lumbosacral ligaments
    J M Olsewski
    Department of Orthopaedic Surgery, State University of New York, Buffalo
    Spine (Phila Pa 1976) 16:336-47. 1991
    ..were examined both grossly and under the dissecting microscope for evidence of compression of fifth lumbar spinal nerves by their respective lumbosacral ligaments...
  45. ncbi Hyperexcitability in sensory neurons of rats selected for high versus low neuropathic pain phenotype
    C N Liu
    Department of Cell and Animal Biology, Institute of Life Sciences, Hebrew University of Jerusalem, 91904, Jerusalem, Israel
    Neuroscience 105:265-75. 2001
    ..Heritable differences in electrical response to axotomy in a specific afferent cell type appear to be a fundamental determinant of neuropathic pain...
  46. pmc Mammalian target of rapamycin signaling in the spinal cord is required for neuronal plasticity and behavioral hypersensitivity associated with neuropathy in the rat
    Curtis O Asante
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    J Pain 11:1356-67. 2010
    ..We also assessed the anatomical distribution of spinal mTOR signaling pathways. Specifically, we ligated rat spinal nerves L5 and L6 to produce a model of neuropathic pain...
  47. ncbi Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model
    Yeong Ray Wen
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Anesthesiology 107:312-21. 2007
    ..Nerve injury-induced ectopic spontaneous activity is essential for the generation of neuropathic pain. The authors examined whether peripheral neural activity is necessary for p38 activation in spinal microglia...
  48. ncbi ATF3 expression in L4 dorsal root ganglion neurons after L5 spinal nerve transection
    Peter J Shortland
    Neuroscience Centre, Institute of Cell and Molecular Science, Bart s and The London School of Medicine and Dentistry, 4 Newark Street, Whitechapel, London E1 2AT, UK
    Eur J Neurosci 23:365-73. 2006
    ..Our results strongly suggest that the surgical exposure of spinal nerves induces ATF3 in the L4-5 DRG, irrespective of whether the L5 nerve is subsequently cut...
  49. ncbi Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain
    T Philip Malan
    Department of Anesthesiology, The University of Arizona, Tucson, Arizona 85724 5114, USA
    Anesthesiology 96:1161-7. 2002
    ..This study tests the hypothesis that loss of spinal activity of gamma-aminobutyric acid (GABA) contributes to the allodynia and hyperalgesia observed after peripheral nerve injury...
  50. ncbi Ectopic discharges from injured nerve fibers are highly correlated with tactile allodynia only in early, but not late, stage in rats with spinal nerve ligation
    Qian Sun
    Neuroscience Research Institute, Peking University, Key Laboratory of Neuroscience, Ministry of Education, Beijing 100083, China
    Exp Neurol 191:128-36. 2005
    ..These findings suggest that ectopic discharges may be crucial in the triggering of neuropathic pain in the early stage, but their importance become more limited over time...
  51. pmc The contributing role of CD14 in toll-like receptor 4 dependent neuropathic pain
    L Cao
    Department of Anesthesiology, HB 7125, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Neuroscience 158:896-903. 2009
    ..Together, these data demonstrate that CD14 plays a contributing role in TLR4-dependent nerve injury-induced neuropathic pain...
  52. pmc Familial occipital and nervus intermedius neuralgia in a Swiss family
    Franz Riederer
    Department of Neurology, University Hospital Zurich, Zurich, Switzerland
    J Headache Pain 11:335-8. 2010
    ..This is suggestive of an X-linked dominant or an autosomal dominant mode of inheritance...
  53. ncbi (-)-Linalool attenuates allodynia in neuropathic pain induced by spinal nerve ligation in c57/bl6 mice
    Laura Berliocchi
    Department of Pharmacobiological Sciences, University of Catanzaro Magna Graecia, Catanzaro 88100, Italy
    Int Rev Neurobiol 85:221-35. 2009
    ..The data suggest that mechanisms other than an action on inflammatory processes may mediate linalool ability to reduce mechanical allodynia in this model of neuropathic pain...
  54. ncbi VR1, but not P2X(3), increases in the spared L4 DRG in rats with L5 spinal nerve ligation
    Tetsuo Fukuoka
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pain 99:111-20. 2002
    ....
  55. ncbi Cervicogenic headache: prevalence and response to local steroid therapy
    M Anthony
    Department of Neurology, Prince of Wales Hospital, Randwick, NSW, Australia
    Clin Exp Rheumatol 18:S59-64. 2000
    ....
  56. ncbi Pharmacological evaluation of the selective spinal nerve ligation model of neuropathic pain in the rat
    Christopher J LaBuda
    Department of Pharmacology, Adolor Corporation, 700 Pennsylvania Drive, Exton, PA 19341, USA
    J Neurosci Methods 144:175-81. 2005
    ..These results suggest that the L5 SNL model can be utilized to determine the anti-allodynic activity of novel compounds...
  57. ncbi Proteomics study of neuropathic and nonneuropathic dorsal root ganglia: altered protein regulation following segmental spinal nerve ligation injury
    Naoka Komori
    Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    Physiol Genomics 29:215-30. 2007
    ..To understand the molecular mechanisms underlying neuropathic pain, we need to comprehend such dynamic aspect of protein modulations that follow nerve injury...
  58. ncbi Intrathecal lidocaine reverses tactile allodynia caused by nerve injuries and potentiates the antiallodynic effect of the COX inhibitor ketorolac
    Weiya Ma
    Pain Mechanisms Laboratory, Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity, Wake Forest University School of Medicine, wisnton Salem, North Carolina 27157 1009, USA
    Anesthesiology 98:203-8. 2003
    ....
  59. ncbi Effects of systemic carbamazepine and gabapentin on spinal neuronal responses in spinal nerve ligated rats
    V Chapman
    Department of Pharmacology, University College London, UK
    Pain 75:261-72. 1998
    ..carbamazepine and gabapentin, on spinal neuronal responses of nerve injured rats (selective ligation of spinal nerves L5 and L6, SNL) and sham-operated rats...
  60. ncbi Occipital afferent activation of second order neurons in the trigeminocervical complex in rat
    K Le Doaré
    Headache Group, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Neurosci Lett 403:73-7. 2006
    ....
  61. ncbi Anti-hyperalgesic and morphine-sparing actions of propentofylline following peripheral nerve injury in rats: mechanistic implications of spinal glia and proinflammatory cytokines
    Vasudeva Raghavendra
    Department of Anesthesiology, HB 7125, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
    Pain 104:655-64. 2003
    ....
  62. ncbi Distinct functional types of macrophage in dorsal root ganglia and spinal nerves proximal to sciatic and spinal nerve transections in the rat
    Ping Hu
    Prince of Wales Medical Research Institute and the University of New South Wales, Randwick, NSW 2031, Australia
    Exp Neurol 184:590-605. 2003
    ..Four functional subtypes of macrophage within the DRGs were distinct from ED1+ foamy cells that phagocytosed myelin after spinal nerve transection...
  63. ncbi Resolution of inflammation-induced axonal mechanical sensitivity and conduction slowing in C-fiber nociceptors
    Andrew Dilley
    Department of Anesthesia, Critical Care and Pain Management, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Pain 9:185-92. 2008
    ..Therefore, in patients with persistent movement-induced radiating limb pain with few clinically apparent signs of nerve damage, there may be a persisting inflammatory lesion affecting the nerve...
  64. ncbi Intrathecal anti-IL-6 antibody and IgG attenuates peripheral nerve injury-induced mechanical allodynia in the rat: possible immune modulation in neuropathic pain
    J L Arruda
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center, HB 7125, 1 Medical Center Drive, Lebanon, NH 03756, USA
    Brain Res 879:216-25. 2000
    ..Spinal glial activation was unaltered by any treatment. These data provide further evidence for the role of central IL-6 and neuroimmune modulation in the etiology of mechanical allodynia following peripheral nerve injury...
  65. ncbi Low-frequency short-time nociceptive stimulation of the greater occipital nerve does not modulate the trigeminal system
    T P Jürgens
    Department of Neurology, University of Regensburg, Regensburg, and Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany
    Cephalalgia 28:842-6. 2008
    ..One explanation for a missing modulatory effect in our study is the relatively short duration of the stimulation...
  66. ncbi Occipital (Arnold) neuralgia secondary to greater occipital nerve schwannoma
    Beatriz Ballesteros-Del Rio
    Department of Internal Medicine, Secretaria 10 HPS, Complejo Hospitalario de Leon, Altos de Nava s n, 24071 Leon, Spain
    Headache 43:804-7. 2003
  67. ncbi Tumor necrosis factor-alpha induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:2517-21. 2003
    ..Parallel inhibition of p38 activation and allodynia may represent a clinically relevant therapeutic window. These data suggest a sequential role for TNF and p38 in the induction of neuropathic pain...
  68. ncbi Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Neurosci 24:10211-22. 2004
    ....
  69. ncbi Osteochondroma of the cervical spine causing occipital nerve neuralgia. Case report
    S Baer-Henney
    Department of Neurosurgery, Hannover Medical School, Germany
    Neurol Res 23:777-9. 2001
    ..Complete removal of the tumor was performed with release of the pain. The literature is reviewed and etiology, diagnosis, treatment and differential diagnosis are discussed...
  70. ncbi Inhibition of spinal protein kinase C reduces nerve injury-induced tactile allodynia in neuropathic rats
    X Y Hua
    Department of Anesthesiology, University of California, San Diego, La Jolla 92093 0818, USA
    Neurosci Lett 276:99-102. 1999
    ..kinases including PKC, PKA and PKG on tactile allodynia in rats with a unilateral tight ligation on L5/L6 spinal nerves (Chung model)...
  71. pmc Morphometric effects of acute shortening of the spine: the kinking and the sliding of the cord, response of the spinal nerves
    Kadir Bahadir Alemdaroğlu
    2nd Orthopedics and Trauma Clinic, Ankara Training and Research Hospital, 76 Sok 9 4 Emek, 06510 Ankara, Turkey
    Eur Spine J 16:1451-7. 2007
    ..The mean sliding of the spinal cord was 9 mm cranially and 7.8 mm caudally. T11 spinal nerves became more vertical caudally, and T12 spinal nerves achieved an ascending position with gradual shortening...
  72. pmc Injury discharges regulate calcium channel alpha-2-delta-1 subunit upregulation in the dorsal horn that contributes to initiation of neuropathic pain
    Amin Boroujerdi
    Department of Pharmacology, University of California Irvine, Irvine, CA 92697, USA
    Pain 139:358-66. 2008
    ..ligated rats after blocking injury induced neural activity with a local brief application of lidocaine on spinal nerves before the ligation. The lidocaine pretreatment blocked ligation-induced discharges in a dose-dependent manner...
  73. pmc Gene transfer of glutamic acid decarboxylase reduces neuropathic pain
    Shuanglin Hao
    Department of Neurology, University of Michigan Health System and Ann Arbor VA Healthcare System, Ann Arbor, MI 48109 0316, USA
    Ann Neurol 57:914-8. 2005
    ..QHGAD67 inoculation also suppressed induction of c-Fos and phosphorylated extracellular signal-regulated kinase 1 and 2 in the spinal cord...
  74. ncbi Toll-like receptor 3 contributes to spinal glial activation and tactile allodynia after nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    J Neurochem 105:2249-59. 2008
    ..Thus, blocking TLR3 in the spinal glial cells might provide a fruitful strategy for treating neuropathic pain...
  75. pmc Upregulation of substance P in low-threshold myelinated afferents is not required for tactile allodynia in the chronic constriction injury and spinal nerve ligation models
    David I Hughes
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom
    J Neurosci 27:2035-44. 2007
    ..They also suggest that any release of substance P from injured Abeta afferents is unlikely to activate NK1 receptors in the dorsal horn or contribute to neuropathic pain...
  76. ncbi Intrathecal interleukin-1 receptor antagonist in combination with soluble tumor necrosis factor receptor exhibits an anti-allodynic action in a rat model of neuropathic pain
    S Sweitzer
    Department of Pharmacology and Toxicology, Hinman Box 7650, Dartmouth College, Hanover, NH 03755, USA
    Neuroscience 103:529-39. 2001
    ..05) in male rats. These findings further support a role for central interleukin-1beta and tumor necrosis factor in the development and maintenance of neuropathic pain through induction of a proinflammatory cytokine cascade...
  77. ncbi Nerve injury-induced tactile allodynia is mediated via ascending spinal dorsal column projections
    H Sun
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Pain 90:105-11. 2001
    ..This neuronal pathway is consistent with the interpretation that tactile allodynia pursuant to peripheral nerve injury is transmitted to the central nervous system by means of large diameter, myelinated fibers...
  78. ncbi Effects of spinal nerve ligation on immunohistochemically identified neurons in the L4 and L5 dorsal root ganglia of the rat
    Donna L Hammond
    Department of Anesthesia, The University of Iowa, Iowa City, Iowa 52242, USA
    J Comp Neurol 475:575-89. 2004
    ..method was used to count neurons in the ipsilateral L4 and L5 DRG 1-20 weeks after ligation of the L5 and L6 spinal nerves, sham surgery, or no surgery...
  79. ncbi Ketamine potentiates the effect of electroacupuncture on mechanical allodynia in a rat model of neuropathic pain
    Cheng Huang
    Key Laboratory of Neuroscience, Neuroscience Research Institute, Peking University, 38 Xueyuan Road, Beijing 100083, PR China
    Neurosci Lett 368:327-31. 2004
    ..p. injection of naloxone (2.0 mg/kg). These results suggested that ketamine potentiate the anti-allodynic of EA in rats with spinal nerve ligation, and endogenous opioid system is likely to be involved in this process...
  80. pmc Neuronal nitric oxide synthase is upregulated in a subset of primary sensory afferents after nerve injury which are necessary for analgesia from alpha2-adrenoceptor stimulation
    Weiya Ma
    Department of Anesthesiology and Center for the Study of Pharmacologic Plasticity in the Presence of Pain, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1009, USA
    Brain Res 1127:52-8. 2007
    ....
  81. pmc Spinal dorsal horn calcium channel alpha2delta-1 subunit upregulation contributes to peripheral nerve injury-induced tactile allodynia
    Chun Ying Li
    Department of Anesthesiology, College of Medicine, University of California, Irvine, Irvine, California 92717, USA
    J Neurosci 24:8494-9. 2004
    ..Thus, changes in presynaptic alpha2delta-1 subunit expression contribute to injury-induced spinal neuroplasticity and central sensitization that underlies neuropathic pain development and maintenance...
  82. pmc Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6
    V Chapman
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Physiol 507:881-94. 1998
    ..2. Ligation of two (L5-L6) of the three spinal nerves that form the sciatic nerve produces a partial denervation of the hindlimb...
  83. ncbi P2Y12 receptors in spinal microglia are required for neuropathic pain after peripheral nerve injury
    Hidetoshi Tozaki-Saitoh
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi, Fukuoka 812 8582, Japan
    J Neurosci 28:4949-56. 2008
    ....
  84. ncbi Proteomic identification of a novel isoform of collapsin response mediator protein-2 in spinal nerves peripheral to dorsal root ganglia
    Tayo Katano
    Department of Medical Chemistry, Kansai Medical University, Moriguchi, Japan
    Proteomics 6:6085-94. 2006
    ..These results suggest that periCRMP-2 is a C-terminal truncated isoform polarized in the peripheral side of spinal nerves and may be involved in nerve degeneration and regeneration.
  85. ncbi Comparison of five different rat models of peripheral nerve injury
    Tom Dowdall
    Johnson and Johnson Pharmaceutical Research and Development, CNS Pain and Alzheimer, Turnhoutseweg 30, B 2340 Beerse, Belgium
    Pharmacol Biochem Behav 80:93-108. 2005
    ..Overall, all five models of neuropathic pain produced signs of allodynia and hyperalgesia to various stimuli. However, the duration and magnitude of the evoked responses varied considerably between the different models...
  86. ncbi Acute peripheral inflammation induces moderate glial activation and spinal IL-1beta expression that correlates with pain behavior in the rat
    S M Sweitzer
    Department of Pharmacology, Dartmouth Medical School, Hanover, NH 03755, USA
    Brain Res 829:209-21. 1999
    ..These findings support a unifying theory that glial activation and cytokine expression have a similar, if not related, role in producing hyperalgesia following either peripheral inflammation or peripheral nerve injury...
  87. ncbi The anatomic relation of lateral mass screws to the spinal nerves. A comparison of the Magerl, Anderson, and An techniques
    R Xu
    Department of Orthopaedic Surgery, Medical College of Ohio, Toledo, USA
    Spine (Phila Pa 1976) 24:2057-61. 1999
    ..CONCLUSIONS: The results of this study indicate that the potential risk of nerve root violation is higher with the Magerl and Anderson techniques than with the An technique...
  88. ncbi Danger of damaging the medial branches of the posterior rami of spinal nerves during a dorsomedian approach to the spine
    A Boelderl
    Department of Traumatology, Anichstr 35, Innsbruck, Austria
    Clin Anat 15:77-81. 2002
    ..specifically, this complication may be caused by damaging the medial branches of the posterior rami of the spinal nerves during lateral retraction of the muscles...
  89. ncbi A combination of gabapentin and morphine mediates enhanced inhibitory effects on dorsal horn neuronal responses in a rat model of neuropathy
    Elizabeth A Matthews
    Department of Pharmacology, University College London, London, United Kingdom
    Anesthesiology 96:633-40. 2002
    ..Improved management of the diverse symptoms and mechanisms of neuropathic pain may arise from combination therapy, based on multiple pharmacologic targets and low drug doses...
  90. ncbi Neuronal nitric oxide synthase mRNA upregulation in rat sensory neurons after spinal nerve ligation: lack of a role in allodynia development
    Z D Luo
    Department of Anesthesiology 0818, University of California, San Diego, La Jolla, California 92093, USA
    J Neurosci 19:9201-8. 1999
    ..DRG) of rats with tactile allodynia because of either tight ligation of the left fifth and sixth lumbar spinal nerves or streptozotocin-induced diabetic neuropathy...
  91. ncbi The role of uninjured C-afferents and injured afferents in the generation of mechanical hypersensitivity after partial peripheral nerve injury in the rat
    Jun Ho Jang
    Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Exp Neurol 204:288-98. 2007
    ....
  92. ncbi Selective mediation of nerve injury-induced tactile hypersensitivity by neuropeptide Y
    Michael H Ossipov
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 22:9858-67. 2002
    ..gracilis. Selective reversal of injury-induced tactile allodynia by NPY receptor antagonists would have significant implications for human neuropathic conditions...
  93. ncbi Transforming growth factor-activated kinase 1 induced in spinal astrocytes contributes to mechanical hypersensitivity after nerve injury
    Hirokazu Katsura
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
    Glia 56:723-33. 2008
    ..Thus, preventing the TAK1/JNK1 signaling cascade in astrocytes might provide a fruitful strategy for treating intractable neuropathic pain...
  94. ncbi Upregulation of FGF-2 in reactive spinal cord astrocytes following unilateral lumbar spinal nerve ligation
    Francesca Madiai
    Department of Internal Medicine, The Ohio State University, William H Davis Medical Research Center, 480 W 9th Avenue, Columbus, OH 43210, USA
    Exp Brain Res 148:366-76. 2003
    ..the expression of fibroblast growth factor-2 (FGF-2) was examined following tight ligation of L5 and L6 spinal nerves. FGF-2 is a pleiotropic cytokine that is synthesized and secreted by neurons and astrocytes...
  95. ncbi Chronic neuropathic pain is accompanied by global changes in gene expression and shares pathobiology with neurodegenerative diseases
    H Wang
    Department of Molecular Pharmacology, Merck Research Laboratories, WP26A 2000, West Point, PA 19486, USA
    Neuroscience 114:529-46. 2002
    ..The results of our study provide a new picture of the molecular mechanisms that underlie the complexity of neuropathic pain and suggest that chronic pain shares common pathobiology with progressive neurodegenerative disease...
  96. ncbi Coupling gene chip analyses and rat genetic variances in identifying potential target genes that may contribute to neuropathic allodynia development
    Carolina R Valder
    Department of Anesthesiology, University of California San Diego, La Jolla, USA
    J Neurochem 87:560-73. 2003
    ....
  97. ncbi VR1 protein expression increases in undamaged DRG neurons after partial nerve injury
    L J Hudson
    Novartis Institute for Medical Sciences, 5 Gower Place, London WC1E 6BN, UK
    Eur J Neurosci 13:2105-14. 2001
    ..This persistence in the nerve proximal to the lesion after nerve section, together with increased VR1 in DRG neurons left undamaged after partial nerve injury, may be crucial to the development or maintenance of neuropathic pain...
  98. ncbi Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat
    Michael P Hefferan
    Division of Basic Medical Sciences, Faculty of Medicine, and School of Pharmacy, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Anesthesiology 99:1180-8. 2003
    ..The current study tested the hypothesis that spinal nerve ligation-induced allodynia is composed of an early prostaglandin-dependent phase, the disruption of which prevents allodynia...
  99. ncbi Lyn tyrosine kinase is required for P2X(4) receptor upregulation and neuropathic pain after peripheral nerve injury
    Makoto Tsuda
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi, Fukuoka, Japan
    Glia 56:50-8. 2008
    ..Together, our findings suggest that Lyn may be a critical kinase mediating nerve injury-induced P2X(4)R upregulation and neuropathic pain...
  100. ncbi Propentofylline, a glial modulating agent, exhibits antiallodynic properties in a rat model of neuropathic pain
    S M Sweitzer
    Department of Pharmacology and Toxicology, Dartmouth College, Hanover, New Hampshire, USA
    J Pharmacol Exp Ther 297:1210-7. 2001
    ....
  101. pmc Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel
    H Saegusa
    Department of Pharmacology and Neurobiology, Graduate School of Medicine, Tokyo Medical and Dental University and CREST, Japan Science and Technology Corporation, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    EMBO J 20:2349-56. 2001
    ..This finding clearly demonstrates that the N-type VDCC is essential for development of neuropathic pain and, therefore, controlling the activity of this channel can be of great importance for the management of neuropathic pain...

Research Grants57

  1. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..pathways involved in brain Fos expression produced by cisplatin and LiCI using lesions of the vagus and GI spinal nerves, and (4) the neurotransmitter receptors that play a role in the brain Fos response produced by cisplatin and ..
  2. Mechanisms/Treatments of Lower Urinary Tract Dysfunction After Spinal Cord Injury
    ANTHONY JOHN KANAI; Fiscal Year: 2013
    ..utilize unique mouse and rat preparations including spinal cord slices, bladder-urethra sheets, sheets with spinal nerves, wall cross-sections and 'inline'primary urothelial, neuronal, interstitial and smooth muscle cells...
  3. Biphasic Intervertebral Disc Regeneration using Biomimetic Scaffolds
    Benjamin R Whatley; Fiscal Year: 2012
    ..Discectomy promotes further compression of the spinal nerves and an increase in patient pain, while current implants exhibit a large compliance mismatch from the native ..
  4. Inspiratory Muscle Activation via High Frequency Spinal Cord Stimulation
    Anthony F DiMarco; Fiscal Year: 2013
    ..Following long term stimulation, pathologic examination of the spinal cord structures, spinal nerves and muscles will be undertaken...
  5. GENETIC BASIS OF VERTEBRATE SEGMENTATION
    Christopher Kintner; Fiscal Year: 2007
    ..organization is critical for the subsequent development of structures such as the vertebral column, associated spinal nerves, muscles and other tissues...
  6. The role of pFRG neurons in the respiratory network.
    SERAPIO BACA; Fiscal Year: 2009
    ..rhythmic center (pFRG or preBotC) while continuously monitoring breathing-related motor activity on distinct spinal nerves (Aim2A)...
  7. Searching for Genes Responsibile for Neuropathic Pain
    Zhigang Luo; Fiscal Year: 2004
    ..to that in sham-operated rats using a well defined rat neuropathic pain model: tight ligation of L5/L6 lumbar spinal nerves. To distinguish potential target genes linked to neuropathic pain from those linked to nerve injury only, gene ..
  8. CENTRAL MECHANISMS MODULATING VISCERAL HYPERSENSITIVITY
    BEVERLY GREENWOOD VAN MEERVELD; Fiscal Year: 2001
    ..Recordings will be made from rat lumbosacral spinal nerves in response to colonic distention following treatment with corticosterone or specific antagonists delivered to ..
  9. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....
  10. Ca permeable non-NMDAr: New spinal sensitization pathway
    Linda Sorkin; Fiscal Year: 2005
    ..We propose to investigate the effects of Ca-permeable non-NMDAr activation on ERK and CREB phosphorylation (using Western blots and immunohistochemistry), expression of c-fos and development of hyperalgesia. ..
  11. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  12. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  13. URINARY BLADDER MUSCARINIC RECEPTOR SUBTYPES
    MICHAEL RUGGIERI; Fiscal Year: 2003
    ..3. To characterize the changes in M2 M3 receptor phosphorylation that may accompany receptor desensitization and receptor up and down regulation. ..
  14. BIFUNCTIONAL OPIOID/CCK LIGANDS FOR PAIN
    Frank Porreca; Fiscal Year: 2006
    ..This novel mechanism of action should yield therapeutic utility as well as provide an increased understanding of opioid-CCK interactions in normal and pathological pain states. ..
  15. Nicotinic Acetylcholine Receptors in Neuropathic Pain
    Michelle Vincler; Fiscal Year: 2008
    ..The results of these studies will further define spinal nicotinic anatomy and functioning in the nerve-injured animal thereby, providing unique potential targets for the pharmacological treatment of neuropathic pain. ..
  16. Cytokine and MAP Kinase Involvement in Neuropathic Pain
    Linda Sorkin; Fiscal Year: 2008
    ..This approach has the potential for avoiding some of the problems that occur with complete inhibition of p38 function. ..
  17. Annual Meeting of the American Pain Society
    Linda Sorkin; Fiscal Year: 2005
    ..Abstracts will be judged on scientific merit and published in The Journal of Pain. We believe that these awards will encourage meeting attendance by trainees. ..
  18. 2008 AUA/SBUR Summer Research Conference
    Arthur Burnett; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Molecular Mechanism of Polarized Cubilin Expression
    JOHN FYFE; Fiscal Year: 2004
    ..Results of these efforts are expected to open a window onto a new aspect of nutrient absorption and membrane receptor biology. ..
  20. G-Protein Coupled Receptor Oligomerization in the CNS
    LAURA STONE; Fiscal Year: 2004
    ..These studies could therefore have a significant impact in future drug discovery and treatment approaches to narcotic addiction and the treatment of severe acute and chronic pain. ..
  21. Continued Development for The Image-guided Surgical Toolkit Project (IGSTK)
    Kevin Cleary; Fiscal Year: 2009
    ....
  22. Regulation of spinal NK1R expression by chronic stress
    Sylvie Bradesi; Fiscal Year: 2006
    ..This proposal is expected to provide new insights into the mechanisms by which stress affects the processing of visceral nociception. ..
  23. Comparison of post-SCI locomotor training techniques
    EDELLE FIELD FOTE; Fiscal Year: 2006
    ..In addition, they will provide information about neural and cardiorespiratory bases of these functional changes. ..
  24. PARASPINAL MUSCLE DENERVATION AND SYMPTOMS IN LUMBAR SS
    Andrew Haig; Fiscal Year: 2005
    ..Subjects will repeat the test battery (MRI, EMG, and clinical evaluation) approximately 18 months later. Appropriate statistics will test each of the four hypotheses. ..
  25. Role of Endogenous Opioid System in the Placebo Effect
    James Campbell; Fiscal Year: 2006
    ..3) Identify relationships between the magnitude of the placebo response and regional mu opioid receptor availability in a non-painful condition. ..
  26. CT fluoroscopy guided robotically assisted lung biopsy
    Kevin Cleary; Fiscal Year: 2005
    ..The system will be validated in phantom and animal studies. The R33 phase will result in a system that is ready for clinical trials. ..
  27. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
  28. HARNESSING MOTONEURON ACTIVITY: FROM LAB TO CLINIC
    Carlo De Luca; Fiscal Year: 2004
    ..As well as testing specific hypotheses, these studies will be used to test and improve the evolving design of the new decomposition system. ..
  29. SELECTIVE BLOCKADE OF TTX-R SODIUM CHANNELS FOR PAIN
    Josephine Lai; Fiscal Year: 2001
    ..These studies may have great practical significance towards the development of an effective therapy for neuropathic pain with few, or no, side effects. ..
  30. MOLECULAR PATHOGENESIS OF FELINE SPINAL MUSCULAR ATROPHY
    JOHN FYFE; Fiscal Year: 2002
    ..Initial candidate genes will be those implicated in human SMA, but otherwise a comparative positional-candidate gene approach will be taken. ..
  31. Astroglial mechanisms for inflammatory pain
    Ru Rong Ji; Fiscal Year: 2010
    ....
  32. Ischemic Stroke Treatment with Microbubbles, a Novel Clot Lysis Therapeutic
    William C Culp; Fiscal Year: 2010
    ..Our proposed pilot study will determine which of these treatments is most successful, and future studies will further explore that treatment. (End of Abstract) ..
  33. Cannabinoids and Neuroimmune Interactions
    Edgar Alfonso Romero Sandoval; Fiscal Year: 2010
    ..The development of new drug strategies to treat acute and chronic pain safely and effectively will result in an invaluable improvement for millions of patients. ..
  34. SENSORY NEURON ADDITION IN RAT
    PAUL FAREL; Fiscal Year: 2002
    ..We will also determine whether the presumed population of type-L neurons differs from nature sensory neurons in the functional differentiation. ..
  35. Paraspinal Denervation in Low Back Pain
    Andrew J Haig; Fiscal Year: 2010
    ..The results will help doctors avoid unnecessary surgery and help scientists to understand more about how spinal stenosis disables so many older people. ..
  36. NITRIC OXIDE REGULATORY SYSTEM IN THE PENIS
    Arthur Burnett; Fiscal Year: 2002
    ....
  37. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  38. Wearable-Sensor System for Monitoring Motor Function
    Carlo J De Luca; Fiscal Year: 2010
    ..The successful development of this technology will be transferred for commercial development with the financial assistance of the Massachusetts Community Technology Foundation. ..
  39. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
  40. OR2020 Workshop: Operating Room of the Future
    Kevin Cleary; Fiscal Year: 2004
    ..The workshop is currently scheduled to be held from April 16-17, 2004, at Turf Valley Conference Center in Ellicot City, Maryland. ..
  41. ERK/MAPK Activation and Pain Hypersensitivity
    Ru Rong Ji; Fiscal Year: 2004
    ..These results should provide insights into the role of intracellular signal transduction cascades in the pathogenesis of pain. ..
  42. Trancellular Labeling from Defined Taste Receptor Cells
    Thomas Finger; Fiscal Year: 2005
    ..These mice also will be informative about the kinetics of protein handling, exocytosis and uptake by various cell types within the taste bud. ..
  43. Software Toolkit for Image Guided Surgery
    Kevin Cleary; Fiscal Year: 2005
    ..Dissemination activities will be undertaken with the aim of fostering the use of the toolkit in research and clinical applications. ..
  44. Role of Spinal GABA Receptors in Neuropathic Pain
    Donna Hammond; Fiscal Year: 2006
    ..abstract_text> ..
  45. PAIN EVOKED RELEASE OF AMINO ACIDS AND PROSTANOIDS
    Tony Yaksh; Fiscal Year: 2005
    ....
  46. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  47. DEVELOPMENT OF THE GUSTATORY SYSTEM
    RICHARD NORTHCUTT; Fiscal Year: 2005
    ..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
  48. Interstitial Cystitis Clinical Research Network (ICCRN)
    Robert Mayer; Fiscal Year: 2007
    ..abstract_text> ..
  49. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  50. MECHANISMS OF NEUROPATHIC PAIN
    James Campbell; Fiscal Year: 2008
    ..These studies will provide a biological rationale for the development of peripheral treatments for neuropathic pain. [unreadable] [unreadable] [unreadable]..
  51. RVM CCK and Neuropathic Pain
    Josephine Lai; Fiscal Year: 2007
    ..In this regard, the proposed experiments may reveal an important role for CCK receptor antagonists as therapy for neuropathic pain. ..
  52. Robotically Assisted Mouse Interventions
    Kevin Cleary; Fiscal Year: 2008
    ..3. Perform a feasibility study using 10 mice to demonstrate the ability of the robot to biopsy the mouse flank as selected on the MRI images and evaluate the accuracy of the system. [unreadable] [unreadable] [unreadable]..
  53. Non-Invasive System for Identifying Neural Behavior
    Carlo De Luca; Fiscal Year: 2009
    ..It will be useful to clinicians for assessing the degree of dysfunction in upper motoneuron diseases such as Cerebral Palsy, Parkinson's Disease, ALS, Stroke, and other disorders. ..
  54. Transgene for morphine tolerance and withdrawal
    Shuanglin Hao; Fiscal Year: 2005
    ....
  55. MECHANISMS AND SITES OF VENTILATORY NEUROGENESIS
    WALTER ST JOHN; Fiscal Year: 2008
    ..Such information might provide insights into dysfunctions of the control of ventilation in humans, such as in "sleep apnea" or the "sudden infant death syndrome." [unreadable] [unreadable] [unreadable]..