vestibular nerve

Summary

Summary: The vestibular part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The vestibular nerve fibers arise from neurons of Scarpa's ganglion and project peripherally to vestibular hair cells and centrally to the VESTIBULAR NUCLEI of the BRAIN STEM. These fibers mediate the sense of balance and head position.

Top Publications

  1. ncbi Functional organization of vestibular commissural connections in frog
    David Malinvaud
    Laboratoire de Neurobiologie des Réseaux Sensorimoteur, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7060, Universite Paris 5, Paris Cedex 06, France
    J Neurosci 30:3310-25. 2010
  2. ncbi New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative Pôle 3C, Comportement, Cerveau, Cognition, Centre de St Charles, Case B, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    Eur J Neurosci 25:47-58. 2007
  3. ncbi The ocular vestibular-evoked myogenic potential to air-conducted sound; probable superior vestibular nerve origin
    Ian S Curthoys
    Vestibular Research Laboratory, School of Psychology, The University of Sydney, NSW, Australia
    Clin Neurophysiol 122:611-6. 2011
  4. ncbi Vestibular functions in motion sickness susceptible individuals
    Fuat Buyuklu
    Department of Otorhinolaryngology, Baskent University Faculty of Medicine, Bahcelievler, 06490, Ankara, Turkey
    Eur Arch Otorhinolaryngol 266:1365-71. 2009
  5. pmc Efferent-mediated fluctuations in vestibular nerve discharge: a novel, positive-feedback mechanism of efferent control
    Meir Plotnik
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 E 58th Street, Chicago, IL 60637, USA
    J Assoc Res Otolaryngol 6:311-23. 2005
  6. pmc Efferent-mediated responses in vestibular nerve afferents of the alert macaque
    Soroush G Sadeghi
    Department of Physiology, McTGill University, 3655 Prom Sir William Osler, Rm 1218, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 101:988-1001. 2009
  7. ncbi Effects of unilateral dysfunction of the inferior vestibular nerve system on postural stability
    Chisato Fujimoto
    Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, Japan
    Clin Neurophysiol 121:1279-84. 2010
  8. ncbi Cavernous angioma of the vestibular nerve: case report and literature review
    Kazuhide Adachi
    Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan
    Surg Neurol 70:82-6; discussion 86. 2008
  9. pmc Characterization of the electrically evoked compound action potential of the vestibular nerve
    Kaibao Nie
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Otol Neurotol 32:88-97. 2011
  10. ncbi Retrograde neuron tracing with microspheres reveals projection of CGRP-immunolabeled vestibular afferent neurons to the vestibular efferent nucleus in the brainstem of rats
    Fang Lu Chi
    Department of Otology and Skull Base Surgery, Eye and ENT Hospital, Fudan University, Shanghai, PR China
    Neuroendocrinology 85:131-8. 2007

Detail Information

Publications259 found, 100 shown here

  1. ncbi Functional organization of vestibular commissural connections in frog
    David Malinvaud
    Laboratoire de Neurobiologie des Réseaux Sensorimoteur, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7060, Universite Paris 5, Paris Cedex 06, France
    J Neurosci 30:3310-25. 2010
    ....
  2. ncbi New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative Pôle 3C, Comportement, Cerveau, Cognition, Centre de St Charles, Case B, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    Eur J Neurosci 25:47-58. 2007
    ..Morphological analysis showed two subtypes of GABAergic neurons: medium and small (30 vs. 10 microm, respectively). This is the first report of reactive neurogenesis in the deafferented VN in the adult mammalian CNS...
  3. ncbi The ocular vestibular-evoked myogenic potential to air-conducted sound; probable superior vestibular nerve origin
    Ian S Curthoys
    Vestibular Research Laboratory, School of Psychology, The University of Sydney, NSW, Australia
    Clin Neurophysiol 122:611-6. 2011
    ..and it has been suggested that it does so by stimulating saccular receptors and afferents in the inferior vestibular nerve and so activating a crossed sacculo-ocular pathway...
  4. ncbi Vestibular functions in motion sickness susceptible individuals
    Fuat Buyuklu
    Department of Otorhinolaryngology, Baskent University Faculty of Medicine, Bahcelievler, 06490, Ankara, Turkey
    Eur Arch Otorhinolaryngol 266:1365-71. 2009
    ..We evaluated vestibular system functioning via a caloric test (which assesses functioning of the superior vestibular nerve) and the vestibular-evoked myogenic potentials (VEMP) test (which assesses inferior vestibular nerve ..
  5. pmc Efferent-mediated fluctuations in vestibular nerve discharge: a novel, positive-feedback mechanism of efferent control
    Meir Plotnik
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, 947 E 58th Street, Chicago, IL 60637, USA
    J Assoc Res Otolaryngol 6:311-23. 2005
    We compared the background discharge of vestibular nerve afferents in barbiturate-anesthetized and unanesthetized, decerebrate chinchillas...
  6. pmc Efferent-mediated responses in vestibular nerve afferents of the alert macaque
    Soroush G Sadeghi
    Department of Physiology, McTGill University, 3655 Prom Sir William Osler, Rm 1218, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 101:988-1001. 2009
    ..We found that efferent-mediated rotational responses could be obtained from vestibular nerve fibers innervating the semicircular canals after conventional afferent responses were nulled by placing the ..
  7. ncbi Effects of unilateral dysfunction of the inferior vestibular nerve system on postural stability
    Chisato Fujimoto
    Department of Otolaryngology, Faculty of Medicine, The University of Tokyo, Japan
    Clin Neurophysiol 121:1279-84. 2010
    To investigate whether disorders of the inferior vestibular nerve (IVN) system affect postural stability.
  8. ncbi Cavernous angioma of the vestibular nerve: case report and literature review
    Kazuhide Adachi
    Department of Neurosurgery, School of Medicine, Keio University, Tokyo, Japan
    Surg Neurol 70:82-6; discussion 86. 2008
    ..We describe a case of a small, extraaxial cavernous angioma of the vestibular nerve. We also propose a reclassification system for cavernous angioma of the CPA based on the tumor's site of ..
  9. pmc Characterization of the electrically evoked compound action potential of the vestibular nerve
    Kaibao Nie
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington, USA
    Otol Neurotol 32:88-97. 2011
    ....
  10. ncbi Retrograde neuron tracing with microspheres reveals projection of CGRP-immunolabeled vestibular afferent neurons to the vestibular efferent nucleus in the brainstem of rats
    Fang Lu Chi
    Department of Otology and Skull Base Surgery, Eye and ENT Hospital, Fudan University, Shanghai, PR China
    Neuroendocrinology 85:131-8. 2007
    ....
  11. pmc Bidirectional plasticity gated by hyperpolarization controls the gain of postsynaptic firing responses at central vestibular nerve synapses
    Lauren E McElvain
    Neurosciences Graduate Program, University of California San Diego, San Diego, CA 92093, USA
    Neuron 68:763-75. 2010
    ..Here, we examine plasticity at a candidate site of motor learning: vestibular nerve synapses onto neurons that mediate reflexive movements...
  12. ncbi Molecular probes of the vestibular nerve. II. Characterization of neurons in Scarpa's ganglion to determine separate populations within the nerve
    Golda Anne Kevetter
    Department of Otolaryngology, University of Texas Medical Branch, 301 University Dr, Galveston, TX 77555 1043, USA
    Brain Res 928:18-29. 2002
    ..This study has provided an anatomical instrument (in addition to intracellular physiological methods) to study separate populations of vestibular afferents...
  13. pmc Effects of biphasic current pulse frequency, amplitude, duration, and interphase gap on eye movement responses to prosthetic electrical stimulation of the vestibular nerve
    Natan S Davidovics
    Departments of Otolaryngology Head and Neck Surgery and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
    IEEE Trans Neural Syst Rehabil Eng 19:84-94. 2011
    An implantable prosthesis that stimulates vestibular nerve branches to restore sensation of head rotation and vision-stabilizing reflexes could benefit individuals disabled by bilateral loss of vestibular (inner ear balance) function...
  14. pmc Effects of canal plugging on the vestibuloocular reflex and vestibular nerve discharge during passive and active head rotations
    Soroush G Sadeghi
    Department of Physiology, McGill University, 3655 Prom Sir William Osler, Room 1218, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 102:2693-703. 2009
    ..Our results demonstrate that afferents innervating plugged canals respond robustly during voluntary movements, a finding that has implications for understanding the effects of canal plugging in clinical practice...
  15. ncbi Central projections of the vestibular nerve: a review and single fiber study in the Mongolian gerbil
    Shawn D Newlands
    Department of Otolaryngology, University of Texas Medical Branch, Galveston, TX 77555 0521, USA
    Brain Res Bull 60:475-95. 2003
    The primary purpose of this article is to review the anatomy of central projections of the vestibular nerve in amniotes...
  16. ncbi The role of the superior vestibular nerve in generating ocular vestibular-evoked myogenic potentials to bone conducted vibration at Fz
    S Iwasaki
    Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Neurophysiol 120:588-93. 2009
    ..If the n10 is due primarily to utricular activation then diseases which affect only the superior division of the vestibular nerve (SVN) should reduce or eliminate n10.
  17. ncbi Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents
    Hortencia Chávez
    Instituto de Fisiología BUAP, Universidad Autonoma de Puebla, Apartado Postal 406, Puebla, Pue CP 72000, Mexico
    Brain Res 1064:1-9. 2005
    ..The present data show that the inhibitory action of the afferent neurons discharge previously described for BH is not restricted to this molecule but is also shared by other H3 antagonists...
  18. ncbi Gamma amino butyric acid (GABA) immunoreactivity in the vestibular nuclei of normal and unilateral vestibular neurectomized cats
    B Tighilet
    , , , 13397 Marseille Cedex 20, France
    Eur J Neurosci 13:2255-67. 2001
    ..Those found in the compensated cats would be more functionally implicated in the dynamic aspects of vestibular compensation...
  19. ncbi Vertigo from herpes zoster oticus: superior or inferior vestibular nerve origin?
    Ying Chih Lu
    Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan
    Laryngoscope 113:307-11. 2003
    This study aims to analyze which division of vestibular nerve in the internal auditory canal is responsible for inducing vertigo in patients with herpes zoster oticus (HZO).
  20. ncbi Effects of vestibular nerve section on sound-evoked myogenic potentials in the sternocleidomastoid muscle of monkeys
    Masahito Tsubota
    Department of Otolaryngology, University of Toyama, 2630 Sugitani, Toyama, Japan
    Clin Neurophysiol 118:1488-93. 2007
    ..The aim of this study was to elucidate the neural pathway for sound-evoked myogenic potentials (SEMPs) in monkeys with characteristics similar to those of vestibular evoked myogenic potentials in humans...
  21. ncbi Treatment of vestibular schwannomas. Why, when and how?
    E Myrseth
    Department of Neurosurgery, Institute of Surgical Science, Haukeland University Hospital, University of Bergen, Bergen, Norway
    Acta Neurochir (Wien) 149:647-60; discussion 660. 2007
    ..Furthermore, we review the literature concerning quality of life in patients with VS. Finally, we present our experience with a management strategy applied to more than 300 cases since 2001...
  22. ncbi The differential response of astrocytes within the vestibular and cochlear nuclei following unilateral labyrinthectomy or vestibular afferent activity blockade by transtympanic tetrodotoxin injection in the rat
    A Campos-Torres
    Department of Microbiology, University of Alabama at Birmingham, 845 19th Street South, BBRB 842, Birmingham, AL 35294, USA
    Neuroscience 130:853-65. 2005
    ..Early trans-ganglionic changes due to vestibular nerve dendrites lesion provoked by the mechanical destruction of vestibular receptors, most probably induced the ..
  23. ncbi Comparative morphology of rodent vestibular periphery. II. Cristae ampullares
    Sapan S Desai
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, M C 512 808 S Wood St, Room 578, Chicago, IL 60612, USA
    J Neurophysiol 93:267-80. 2005
    ..Apart from this eminentia cruciatum, there are no statistical differences between horizontal and vertical cristae with regard to area, width, length, the number and type of hair cells, and number of calretinin-labeled calyx afferents...
  24. ncbi Imaging findings of cochlear nerve deficiency
    Christine M Glastonbury
    Department of Radiology, University Hospital, Salt Lake City, UT, USA
    AJNR Am J Neuroradiol 23:635-43. 2002
    ..Depiction of cochlear nerve integrity may be important for diagnosis and management of SNHL...
  25. ncbi Vestibular nerve section versus intratympanic gentamicin for Meniere's disease
    Todd A Hillman
    Pittsburgh Ear Associates, 429 East North Avenue, Suite 422, Pittsburgh, PA, USA
    Laryngoscope 114:216-22. 2004
    b>Vestibular nerve section and transtympanic gentamicin administration are procedures with proven efficacy in the treatment of vertigo associated with Meniere's disease refractory to medical management...
  26. ncbi The effect of vestibular nerve section upon tinnitus
    D M Baguley
    Department of Audiology, University of Cambridge, Cambridge, UK
    Clin Otolaryngol Allied Sci 27:219-26. 2002
    This paper reviews the published evidence regarding the effect of vestibular nerve section upon tinnitus...
  27. ncbi Effects of unilateral vestibular deafferentation on the linear vestibulo-ocular reflex evoked by impulsive eccentric roll rotation
    S T Aw
    Neurology Department, Royal Prince Alfred Hospital, Sydney NSW 2050, Australia
    J Neurophysiol 89:969-78. 2003
    ..After UVD, LVOR is bilaterally and largely symmetrically reduced, but latency remains unchanged and modulation by viewing distance is still present...
  28. pmc Acute rotatory vertigo caused by a small haemorrhage of the vestibular cortex
    J Boiten
    J Neurol Neurosurg Psychiatry 74:388. 2003
  29. ncbi Gentamicin ototoxicity: clinical features and the effect on the human vestibulo-ocular reflex
    Gail Ishiyama
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Acta Otolaryngol 126:1057-61. 2006
    ..Sinusoidal rotational stimuli with high accelerations such as the bedside head-thrust test or rotational step changes in velocity are useful to diagnose bilateral vestibulopathy...
  30. ncbi Subjective visual tilt and lateral instability after vestibular deafferentation
    Anna Hafstrom
    Department of Otorhinolaryngology, Head and Neck Surgery, Clinical Sciences, Lund University Hospital, Lund, Sweden
    Acta Otolaryngol 126:1176-81. 2006
    ..Defective utricular function, reflected by deviation of the perceived visual horizontal or vertical, cannot by itself explain increased postural sway in the lateral direction for patients with unilateral vestibular deafferentation (uVD)...
  31. ncbi Convergence of the anterior semicircular canal and otolith afferents on cat single vestibular neurons
    X Zhang
    Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
    Exp Brain Res 147:407-17. 2002
    ..The remaining vestibulospinal and vestibulooculospinal neurons descended through the ipsilateral lateral vestibulospinal tract...
  32. ncbi [Vestibular compensation in patients with vestibular neuronitis]
    Anna Pajor
    Katedra Otolaryngologii UM w Lodzi, Uniwersytecki Szpital Kliniczny nr 1 im N Barlickiego
    Otolaryngol Pol 60:747-52. 2006
    ..The aim of the study was to compare the clinical and ENG outcome in different time in patients with peripheral vestibular loss diagnosed as a vestibular neuronitis in order to establish degree of compensation...
  33. ncbi Epidemiology of vertigo
    Hannelore K Neuhauser
    Department of Epidemiology, Robert Koch Institute, Berlin, Germany
    Curr Opin Neurol 20:40-6. 2007
    ..This article gives an overview of the epidemiology of the vestibular symptom vertigo and of four specific vestibular disorders: benign paroxysmal positional vertigo, migrainous vertigo, Menière's disease and vestibular neuritis...
  34. ncbi Age-related changes in vestibular evoked myogenic potentials
    Krister Brantberg
    Department of Audiology, Karolinska Hospital, Stockholm, Sweden
    Audiol Neurootol 12:247-53. 2007
    ..Thus, the finding of a large VEMP amplitude in response to a high-intensity sound stimulation is not, per se, distinctive for a significant vestibular hypersensitivity to sounds...
  35. ncbi Gradual and reversible central vestibular reorganization in frog after selective labyrinthine nerve branch lesions
    Fumiyuki Goto
    Department of Physiology, Pettenkoferstrasse 12, 80336 Munich, Germany
    Exp Brain Res 147:374-86. 2002
    ..nerve section, became receptive to additional, excitatory synaptic inputs, preferentially from intact vestibular nerve afferent fibers...
  36. ncbi Total sleep deprivation can increase vestibulo-ocular responses
    G Quarck
    UPRES EA no 3917 Attention, Orientation et Fonctions Exécutives, Faculte de Medecine, Universite de Caen Basse Normandie, Caen Cedex, France
    J Sleep Res 15:369-75. 2006
    ..It is therefore our hypothesis that the difference between the effects of these two vestibular stimulations results from a sleep deprivation-induced modulation of the right temporoparietal cortex...
  37. ncbi Subcellular immunolocalization of NMDA receptor subunit NR1, 2A, 2B in the rat vestibular periphery
    Gail Ishiyama
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res 935:16-23. 2002
    ..The receptor subtype(s) may be a combination of NR1/NR2A, NR1/NR2B, and/or NR1/NR2A/NR2B...
  38. ncbi Preservation of tap vestibular evoked myogenic potentials despite resection of the inferior vestibular nerve
    Krister Brantberg
    Department of Audiology, Karolinska Hospital, Stockholm, Sweden
    J Vestib Res 14:347-51. 2004
    ..Postoperative caloric testing suggested sparing of superior vestibular nerve function on the operated side...
  39. ncbi Ocular vestibular evoked myogenic potentials (OVEMPs) produced by air- and bone-conducted sound
    Neil P McAngus Todd
    Faculty of Life Science, University of Manchester, Manchester M60 1QD, UK
    Clin Neurophysiol 118:381-90. 2007
    ..To determine the origin and properties of short latency extraocular potentials produced by activation of the vestibular apparatus using two modes of acoustic stimulation...
  40. ncbi Reflections of efferent activity in rotational responses of chinchilla vestibular afferents
    Meir Plotnik
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurophysiol 88:1234-44. 2002
    ..We conclude that the efferent system receives a sufficiently powerful vestibular input from both the ipsilateral and contralateral labyrinths to affect afferent discharge...
  41. ncbi Recovery of subjective visual horizontal after unilateral vestibular deafferentation by intratympanic instillation of gentamicin
    Yoshinari Takai
    Department of Otolaryngology, University of Tokyo, Japan
    J Vestib Res 16:69-73. 2006
    ..The reasons why the recovery of SVH took longer than the disappearance of spontaneous nystagmus are discussed in this report...
  42. ncbi [Bilateral vestibular loss. Diagnosis and follow-up]
    K A Frese
    Klinik fur Hals, Nasen und Ohrenheilkunde, Kopf und Halschirurgie, Universitatsklinikum Kiel
    HNO 51:221-5. 2003
    ..Atypical symptom in patients with bilateral vestibular loss is head movement-induced oscillopsia. The paucity of precise complaints in many patients is surprising. Therefore, bilateral loss of vestibular function is often undiagnosed...
  43. ncbi Independent effects of simultaneous inputs from the saccule and lateral semicircular canal. Evaluation using VEMPs
    Shotaro Karino
    Department of Otolaryngology Head and Neck Surgery, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Neurophysiol 116:1707-15. 2005
    ..To determine the effects of stimulation of bilateral lateral semicircular canals (LSCCs) by accelerated rotation and caloric stimulation of unilateral LSCC on vestibular evoked myogenic potentials (VEMPs) in healthy volunteers...
  44. ncbi Vestibular evoked myogenic potentials: history and overview
    Guangwei Zhou
    Massachusetts Eye and Ear Infirmary, Boston, USA
    Am J Audiol 13:135-43. 2004
    ..limb arises from acoustically sensitive cells in the saccule, with signals conducted via the inferior vestibular nerve. We will review the history of the response and detail the anatomy and physiology associated with the test...
  45. ncbi Function of semicircular canals, utricles and saccules in deaf children
    Arne Tribukait
    Department of Audiology, Karolinska Hospital, Stockholm, Sweden
    Acta Otolaryngol 124:41-8. 2004
    ..To study vestibular function in deaf children...
  46. ncbi Benign paroxysmal positional vertigo: diagnosis and treatment
    F Salvinelli
    Department of Otolaryngology, University Campus Bio Medico Rome, Italy
    Clin Ter 155:395-400. 2004
    ..In our review we consider the possible pathogenesis of this disease and the best therapies, like repositioning maneuvers, in a patient affected by BPPV...
  47. ncbi Properties of horizontal semicircular canal nerve-activated vestibulospinal neurons in cats
    Akemi Sugita
    Department of Otolaryngology, St Marianna University School of Medicine, 2 16 1 Sugao, Miyamae ku, Kawasaki, 216 8511 Kanagawa, Japan
    Exp Brain Res 156:478-86. 2004
    ..It is likely that the majority of HC nerve-activated vestibulospinal neurons terminate in the cervical cord and have strong connections with neck motoneurons...
  48. ncbi Clinical experience with the vestibular evoked myogenic potential
    David A Zapala
    Audiology Section, Department of Otolaryngology Head and Neck Surgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Am Acad Audiol 15:198-215. 2004
    ..Combining both tests improved sensitivity. However, VEMP false-positive rates hampered specificity. VEMP testing may be refined to improve false-positive rates and clinical utility...
  49. ncbi Surgical treatment of peripheral vertigo and vertiginous diseases
    Nebil Goksu
    Department of Otolaryngology and Head and Neck Surgery, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey
    ORL J Otorhinolaryngol Relat Spec 67:1-9. 2005
    ..Selection of the approach depends on the type of vertiginous disease. This review mainly focuses on the current status and outcome of the surgeries used in the treatment of a variety of vertiginous diseases...
  50. ncbi Vestibular evoked myogenic potentials versus vestibular test battery in patients with Meniere's disease
    Steven D Rauch
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston University Medical Center, Boston, Massachusetts 02114, USA
    Otol Neurotol 25:981-6. 2004
    ....
  51. ncbi Latency of adaptive vergence eye movements induced by vergence-vestibular interaction training in monkeys
    Teppei Akao
    Department of Physiology, Hokkaido University School of Medicine, West 7, North 15, 060 8638, Sapporo, Japan
    Exp Brain Res 158:129-32. 2004
    ..These results indicate that vestibular information can be used effectively to initiate vergence eye movements following vergence-vestibular training...
  52. ncbi Responses of primary vestibular neurons to galvanic vestibular stimulation (GVS) in the anaesthetised guinea pig
    Juno Kim
    The Vestibular Research Laboratory, School of Psychology, The University of Sydney, NSW 2006, Australia
    Brain Res Bull 64:265-71. 2004
    ....
  53. ncbi Bilateral processing of vestibular responses revealed by injecting lidocaine into the eighth cranial nerve in vitro
    Michael Ariel
    Department of Anatomy and Neurobiology, 1402 S Grand Boulevard, Saint Louis University, Saint Louis, MO 63104 1004, USA
    Brain Res 999:106-17. 2004
    ..An alternate model is described in which vestibular neurons receive bilateral excitation, and that excitatory input is antagonized by crossed inhibition during contraversive motion...
  54. ncbi Otolith and canal integration on single vestibular neurons in cats
    Y Uchino
    Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo, 160 8402, Japan
    Exp Brain Res 164:271-85. 2005
    ..of vestibular afferent inputs onto single vestibular neurons activated by selective stimulation of individual vestibular nerve branches...
  55. ncbi The role of vestibular rehabilitation in the treatment of Meniere's disease
    Kim R Gottshall
    Department of Defense Spatial Orientation Center, Naval Medical Center San Diego, CA 92134, USA
    Otolaryngol Head Neck Surg 133:326-8. 2005
    ..To study the role of vestibular rehabilitation is treating patients with Meniere's disease...
  56. ncbi A general framework for neurobiological modeling: an application to the vestibular system
    Chris Eliasmith
    Department of Philosophy, Department of Systems Design Engineering, University of Waterloo, Waterloo, Ont, Canada
    Neurocomputing 44:1071-6. 2002
    ..The model is constructed using general principles of neurobiological simulation (J. Neurophys. 84 (2000) 2113)...
  57. ncbi Vestibular evoked myogenic potentials in brainstem stroke
    Chia Hung Chen
    Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei
    Laryngoscope 113:990-3. 2003
    ..The purpose of the study was to establish the role of VEMP in patients with brainstem stroke...
  58. ncbi Axonal pathways and projection levels of anterior semicircular canal nerve-activated vestibulospinal neurons in cats
    Naoharu Kitajima
    Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
    Neurosci Lett 406:1-5. 2006
    ..Most of the c-LVST neurons were also activated antidromically from the oculomotor nucleus, suggesting that they are closely related to the control of combined eye-head movements...
  59. ncbi The effects of unilateral eighth nerve block on fictive VOR in the turtle
    Michael S Jones
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 S Grand Blvd, St Louis, MO 63104, USA
    Brain Res 1094:149-62. 2006
    ..We examined the effect of sectioning or injecting lidocaine (1-2 microL of 0.5%) into the right vestibular nerve. Nerve block caused a striking phase shift in the evoked response of right oculomotor and left trochlear ..
  60. pmc Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Exp Brain Res 176:575-87. 2007
    ..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation...
  61. ncbi [Vestibular evoked myogenic potentials]
    K F Hamann
    Hals, Nasen, Ohrenklinik und Poliklinik, Klinikum rechts der Isar, TU Munchen, Ismaninger Strasse 22, 81675 Munchen
    HNO 54:415-26; quiz 427. 2006
    ..neuro-otologic method which gives specific information about the function of the sacculus and the inferior vestibular nerve on each side separately...
  62. ncbi Function tests of the otolith or statolith system
    Herman Kingma
    Division of Balance Disorders, Department of ENT, University Hospital Maastricht, Maastricht Research Institute Brain and Behaviour, Maastricht University, The Netherlands
    Curr Opin Neurol 19:21-5. 2006
    ..This review aims to provide an overview of recent advances in tests to evaluate otolith function over the last 2 years...
  63. ncbi Central projections of the saccular and utricular nerves in macaques
    Shawn D Newlands
    Department of Otolaryngology, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Comp Neurol 466:31-47. 2003
    ....
  64. ncbi [Effect of nitric oxide in vestibular compensation]
    Zi dong Jiang
    Department of Otolaryngology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:612-4. 2003
    ..To study the effect of nitric oxide (NO) in vestibular compensation after unilateral vestibular deafferentation...
  65. ncbi Signal processing of semicircular canal and otolith signals in the vestibular nuclei during passive and active head movements
    Robert A McCrea
    Department of Neurobiology, Pharmacology, and Physiology, University of Chicago, Chicago, Illinois 60637, USA
    Ann N Y Acad Sci 1004:169-82. 2003
    The vestibular nerve sends signals to the brain that code the movement and position of the head in space...
  66. ncbi An in situ hybridization and immunofluorescence study of GABA(A) and GABA(B) receptors in the vestibular nuclei of the intact and unilaterally labyrinthectomized rat
    Lyndell Eleore
    LNRS, CNRS Paris 5, Centre Universitaire des Saints Peres, 45 Rue des Saints Peres, 75270, Paris Cedex 06, France
    Exp Brain Res 160:166-79. 2005
    ..e., in the restoration of a normal resting discharge of the deafferented vestibular neurons and consequently in the recovery of a normal posture and eye position...
  67. ncbi Differential intrinsic response dynamics determine synaptic signal processing in frog vestibular neurons
    Mathieu Beraneck
    Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7060, Universite Paris Descartes, 75270 Paris Cedex 06, France
    J Neurosci 27:4283-96. 2007
    ....
  68. ncbi Intratympanic gentamicin therapy for vertigo in nonserviceable ears
    P W Bauer
    Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, Boston, MA, USA
    Am J Otolaryngol 22:111-5. 2001
    ..CONCLUSIONS: Intratympanic gentamicin therapy offers a minimally invasive, ambulatory, low morbidity, cost-effective means of managing vertigo in patients with nonserviceable hearing...
  69. ncbi How body position changes visual vertical perception after unilateral vestibular loss
    Christophe Lopez
    Laboratoire de Neurobiologie Integrative et Adaptative, CNRS Université de Provence, Marseille, France
    Neuropsychologia 46:2435-40. 2008
    ..The present data indicate that visual vertical perception improves when postural control is more demanding. This suggests that postural balance is a key reference for vertical perception, at least up to one month after vestibular loss...
  70. ncbi Vestibular-evoked myogenic potential thresholds normalize on plugging superior canal dehiscence
    Miriam S Welgampola
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Neurology 70:464-72. 2008
    ..Lowered thresholds for eliciting vestibular-evoked myogenic potentials (VEMPs) provide additional conformation...
  71. ncbi Preserved vestibular evoked myogenic potentials (VEMP) in some patients with walking-induced oscillopsia due to bilateral vestibulopathy
    Krister Brantberg
    Department of Audiology, Karolinska Hospital, Stockholm, Sweden
    J Vestib Res 17:33-8. 2007
    ..Further, the findings in these patients suggest that saccular function probably contributes little to prevent walking-induced vertical oscillopsia...
  72. ncbi Mechanism of posterior semicircular canal stimulation in patients with benign paroxysmal positional vertigo
    V Honrubia
    UCLA School of Medicine, Victor Goodhill Ear Center, Division of Head and Neck Surgery, Los Angeles, CA 90095-1624, USA
    Acta Otolaryngol 121:234-40. 2001
    ..The estimated pressure exerted on the crista is approximately 10(-2) dyn/cm2...
  73. ncbi Tuning in caudal fastigial nucleus units during natural and galvanic labyrinth stimulation
    H G Schlosser
    , Fachbereich Humanmedizin, , Department of Physiology, Germany
    Neuroreport 12:1443-7. 2001
    ..Two classes of neurons could be distinguished: up to 1 Hz responders and up to 10 Hz responders. In addition a group of fastigial cells showed a tuning within a small range of frequencies (sharp-tuning responders)...
  74. ncbi Transmastoid labyrinthectomy versus translabyrinthine vestibular nerve section: does cutting the vestibular nerve make a difference in outcome?
    Antonio De la Cruz
    House Ear Institute, Los Angeles, California 90057, USA
    Otol Neurotol 28:801-8. 2007
    Analyze differences in outcomes between labyrinthectomy with and without vestibular nerve section, including characteristics of symptoms and time course for improvement.
  75. ncbi Labyrinthectomy versus vestibular neurectomy: long-term physiologic and clinical outcomes
    D J Eisenman
    Department of Otolaryngology-Head and Neck Surgery, Division of Otology-Neurotology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otol Neurotol 22:539-48. 2001
    ..There is a high incidence of incomplete VC after both procedures, though this does not usually produce a significant balance handicap...
  76. ncbi A place principle for vertigo
    Richard R Gacek
    Department of Otolaryngology, Head and Neck Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Auris Nasus Larynx 35:1-10. 2008
    ..To provide a road map of the vestibular labyrinth and its innervation leading to a place principle for different forms of vertigo...
  77. ncbi The clinical utility of search coil horizontal vestibulo-ocular reflex testing
    Paul Kessler
    Otoneurology Laboratory, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Acta Otolaryngol 128:29-37. 2008
    ..It identifies high and low frequency/acceleration vestibular abnormalities that are frequently missed using other methods...
  78. ncbi Otolith-activated vestibulothalamic neurons in cats
    H Meng
    Department of Physiology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan
    Exp Brain Res 141:415-24. 2001
    ..b>Vestibular nerve branches other than the tested nerve were transected...
  79. ncbi Horizontal vestibulo-ocular reflex dynamics in acute vestibular neuritis and viral labyrinthitis: evidence of otolith-canal interaction
    Raphael Maire
    Clinic of Otolaryngology Head and Neck Surgery, Neurotology Unit, University Hospital Lausanne, Lausanne, Switzerland
    Acta Otolaryngol 124:36-40. 2004
    ....
  80. ncbi Properties of utricular-activated vestibular neurons that project to the contralateral vestibular nuclei in the cat
    R Bai
    Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
    Exp Brain Res 147:419-25. 2002
    ..We also studied convergent inputs from the posterior semicircular canal (PC) nerve onto UT-activated commissural neurons. Five of 27 UT-activated commissural neurons received converging inputs from the PC nerves...
  81. ncbi Vestibular compensation after ganglionectomy: ultrastructural study of the tangential vestibular nucleus and behavioral study of the hatchling chick
    Eric M Aldrich
    Department of Anatomy and Cell Biology and Neuroscience Program, George Washington University Medical Center, Washington, DC 20037, USA
    J Neurosci Res 67:122-38. 2002
    ..This rapid behavioral recovery of function distinguishes the vestibular system from other sensory systems, which, in general, exhibit much less robust recovery after injury to their peripheral receptors...
  82. ncbi The behavior and vestibular nuclear morphology of otoconia-deficient pallid mutant mice
    D R Trune
    J Neurogenet 1:53-69. 1983
    ..It was tentatively concluded that the sensory deprivation resulting from reduced gravity receptor input was responsible for the behavioral and central morphological abnormalities...
  83. ncbi Vestibular function in auditory neuropathy
    K Sheykholeslami
    Department of Otolaryngology, Faculty of Medicine, Tokyo University, Japan
    Acta Otolaryngol 120:849-54. 2000
    ..They additionally manifest a disorder of the vestibular nerve and its end organs...
  84. ncbi [Hearing evaluation in patients with vertigo]
    Wiesław Konopka
    Zakład Diagnostyki Audiologicznej i Elektrofizjologicznej, Katedry Chirurgii Głowy i Szyi UM w Lodzi
    Otolaryngol Pol 60:239-41. 2006
    ..Vertigo is the illusory sensation of motion. True vertigo is caused by pathology in the peripheral end organ, the vestibular nerve, and the pathways that connect them in the brainstem and rarely, in the cortex.
  85. ncbi Plastic changes underlying vestibular compensation in the guinea-pig persist in isolated, in vitro whole brain preparations
    N Vibert
    Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, CNRS ESA 7060, Paris, France
    Neuroscience 93:413-32. 1999
    ..to search for a similar imbalance in vitro in brains taken from labyrinthectomized animals, where the intact vestibular nerve is cut during the dissection...
  86. ncbi Afferent innervation of the vestibular nuclei in the chinchilla. II. Description of the vestibular nerve and nuclei
    A Newman
    Division of Head and Neck Surgery, UCLA School of Medicine 90024 1624
    Brain Res 597:278-97. 1992
    ..8-0.9 mm medial to the root entry zone. It contained a few large cells (greater than 20 microns in diameter), many medium-sized cells, and some small cells.(ABSTRACT TRUNCATED AT 400 WORDS)..
  87. ncbi Vestibular evoked myogenic potentials in humans: a review
    C Ferber-Viart
    Fédération d Explorations Audiovestibulaires, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Acta Otolaryngol 119:6-15. 1999
    ..to originate in the saccule, the afferent pathways being either the vestibulocochlear nerve or the inferior vestibular nerve, and the efferent pathways the vestibulospinal tract...
  88. ncbi [Herpes zoster oticus: symptom constellation and serological diagnosis]
    L E Walther
    Universitäts HNO Klinik, Friedrich Schiller Universitat Jena
    Laryngorhinootologie 83:355-62. 2004
    ..The clinical symptoms, the symptom constellation, diagnostics and therapy, however, have been examined till now only in few studies...
  89. ncbi Differential central projections of vestibular afferents in pigeons
    J D Dickman
    Department of Surgery Otolaryngology, University of Mississippi Medical Center, Jackson 39216, USA
    J Comp Neurol 367:110-31. 1996
    ..the individual semicircular canal and otolith organs was produced by sectioning individual branches of the vestibular nerve that innervate the different receptor organs and applying crystals of horseradish peroxidase, or a ..
  90. ncbi Development of the vestibular apparatus and central vestibular connections in a wallaby (Macropus eugenii)
    S U McCluskey
    Department of Anatomy, School of Medical Sciences, The University of NSW, Sydney, N S W, Australia
    Brain Behav Evol 71:271-86. 2008
    ..b>Vestibular nerve fibers can be traced into the brainstem to the developing vestibular nuclei, which are not yet ..
  91. ncbi Floccular modulation of vestibuloocular pathways and cerebellum-related plasticity: An in vitro whole brain study
    A L Babalian
    Laboratoire de la Neurobiologie des Réseaux Sensorimoteures, Centre National de la Recherche Scientifique, 75270 Paris Cedex 06, France
    J Neurophysiol 84:2514-28. 2000
    ..properties; to search for possible flocculus-dependent plasticity at the FTN level by pairing of vestibular nerve and floccular stimulations; and to study the possibility of induction of long-term depression (LTD) in ..
  92. ncbi Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents
    J Bäurle
    Freie Universitat Berlin, Fachbereich Humanmedizin, Universitatsklinikum Benjamin Franklin, Department of Physiology, Germany
    J Comp Neurol 402:111-28. 1998
    ..Calb + terminals were also present in the small cell group Y and Cajal's interstitial nucleus of the vestibular nerve as well as in defined areas of the reticular formation. All Calb + PVA are strictly unilateral...
  93. ncbi Stress in hearing and balance in Meniere's disease
    K C Horner
    Equipe Inserm EPI 9902, Laboratoire Otologie NeuroOtologie, University Mediterranee Aix Marseille II, Faculte de Medecine Nord, Marseille, Cedex 20, France
    Noise Health 5:29-34. 2003
    ..we carried out a retrospective study on a series of Ménière's patients who had undergone a neurotomy of the vestibular nerve in the dept of ORL at the Hopital Nord, Marseille...
  94. ncbi [Squirrel monkey--an ideal primate (correction of prmate) model of space physiology]
    K Matsunami
    Institute of Equilibrium Research, Gifu University School of Medicine, Japan
    Biol Sci Space 11:87-111. 1997
    ..A transfer function was proposed to explain the behaviors of regular and irregular unit activity of vestibular nerve fibers...
  95. pmc Muscarinic acetylcholine receptor subtype expression in avian vestibular hair cells, nerve terminals and ganglion cells
    G Q Li
    Department of Otolaryngology, University of Texas Medical Branch at Galveston, Galveston, TX 77550 1063, USA
    Neuroscience 146:384-402. 2007
    ..M1-M5) in the pigeon vestibular end organs (semicircular canal ampullary cristae and utricular maculae), vestibular nerve fibers and the vestibular (Scarpa's) ganglion using tissue immunohistochemistry (IH), dissociated single cell ..
  96. ncbi The central vestibular complex in dolphins and humans: functional implications of Deiters' nucleus
    A Kern
    Department of Anatomy III, J W Goethe University Frankfurt a M, Germany
    Brain Behav Evol 73:102-10. 2009
    ..Concomitantly, the vestibular nerve and most of the vestibular nuclei are thin and small, respectively, in comparison with those in terrestrial ..
  97. ncbi The results of vestibular evoked myogenic potentials, with consideration of age-related changes, in vestibular neuritis, benign paroxysmal positional vertigo, and Meniere's disease
    Seok Min Hong
    Department of Otorhinolaryngology Head and Neck Surgery, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, Korea
    Acta Otolaryngol 128:861-5. 2008
    ..We found different abnormal VEMP rates among the three diseases, as well as differences in the proportion of parameters that were abnormal, according to the type of disease...
  98. ncbi Cogan's syndrome: clinical significance of antibodies against the inner ear and cornea
    C Helmchen
    Department of Neurology, University of Munich, Klinikum Grosshadern, Germany
    Acta Otolaryngol 119:528-36. 1999
    ..In the acute stage, HR-MRI revealed abnormal MRI signals in the vestibule, semicircular canals, vestibular nerve, or cochlea...
  99. ncbi Contributions of regularly and irregularly discharging vestibular-nerve inputs to the discharge of central vestibular neurons in the alert squirrel monkey
    C Chen-Huang
    Department of Pharmacological and Physiological Sciences, University of Chicago, IL 60637, USA
    Exp Brain Res 114:405-22. 1997
    ..Many of the neurons were monosynaptically related to the ipsilateral vestibular nerve. Eye-position and vestibular components of the rotation response were separated by multiple regression...
  100. ncbi Development of calretinin immunoreactivity in the mouse inner ear
    C J Dechesne
    Laboratoire de Neurophysiologie Sensorielle, Unité INSERM 254, Montpellier, France
    J Comp Neurol 346:517-29. 1994
    ..At postnatal day 4 (P4), a few vestibular nerve fibers and ganglion neurons were reactive...
  101. ncbi [Ramsay Hunt syndrome with cranial polyneuropathy involving cranial nerves VII, VIII, IX, and X]
    Akemi Sugita-Kitajima
    Department of Otolaryngology, St Marianna University School of Medicine, Kawasaki
    Nihon Jibiinkoka Gakkai Kaiho 112:656-9. 2009
    In addition to facial and vestibular nerve paralysis, patients with Ramsay Hunt syndrome may also show glossopharyngeal, vagal, and hypoglossal nerve paralysis...

Research Grants66

  1. Contribution of c-Jun N-terminal kinase activity to vestibular schwannoma growth
    Marlan R Hansen; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vestibular schwannomas (VSs) develop from the Schwann cells (SCs) of the vestibular nerve. They cause significant morbidity including deafness, tinnitus, facial paralysis, imbalance, and brainstem ..
  2. Structure-function analyses on novel processes of type II vestibular hair cells
    Jennifer S Stone; Fiscal Year: 2013
    ..in the inner ear, which convert head movements into electrical signals that are sent to the brain via the vestibular nerve. Hair cell death has many causes, including gene mutation, injury, infection, therapeutic surgery and drug ..
  3. Electrical Stimulation to Restore Three Dimensional Vestibular Sensation
    Charles C Della Santina; Fiscal Year: 2012
    ..Because the vestibular nerve should be intact in many of these patients, electrical stimuli encoding head rotation should be able to drive ..
  4. PHYSIOLOGY OF VESTIBULAR COMPENSATION
    Charles C Della Santina; Fiscal Year: 2013
    ..Sudden, permanent loss of vestibular nerve input from one labyrinth causes disequilibrium and visual blurring due to disruption of the vestibulo-ocular ..
  5. Safe Direct Current Neural Stimulation System
    GENE YEVGENY FRIDMAN; Fiscal Year: 2013
    ..In a very well-characterized chinchilla model of prosthetic stimulation of the vestibular nerve, we will compare performance of a neural prosthesis incorporating SCDS technology to that of a "traditional" ..
  6. Vestibulo-spinal influences on reflex performance
    GREG GDOWSKI; Fiscal Year: 2009
    ..Secondary VS neurons will be orthodromically identified from the vestibular nerve and antidromically identified as projecting to the spinal cord...
  7. CELLULAR ANALYSIS OF THE VESTIBULO-OCULAR REFLEX
    Sascha du Lac; Fiscal Year: 2013
    ..The influence of vestibular nerve, commissural, and cerebellar synaptic activity will be examined in cerebellar target neurons and in other ..
  8. RESEARCH AND TRAINING CENTER IN HEARING AND BALANCE
    Eric Young; Fiscal Year: 1999
    ..of awake, behaving animals; electrophysiological study of recovery processes in the vestibular nuclei after vestibular nerve section; behavioral study of short-term adaptation of the vestibuloocular reflex in normal human subjects; ..
  9. WEARABLE ARTIFICIAL LABYRINTH IN MOTION SICKNESS/VERTIGO
    WESLEY KRUEGER; Fiscal Year: 2005
    ..the symptoms of motion sickness and in the rehabilitative process in patients with dizziness following vestibular nerve section or removal of a skull base lesion such as acoustic tumor...
  10. Vestibular Hair Cell Regeneration
    LARRY HOFFMAN; Fiscal Year: 2007
    ..of GM; 2) Parallel measurements of the changes in the Vestibulo Ocular Reflex (VOR) function and of single vestibular nerve fibers physiological responses to be compared with the anatomical changes; 3) Investigation of the potential ..
  11. MORPHOPHYSIOLOGICAL ANALYSIS OF VESTIBULAR NEURONS
    ADRIAN PERACHIO; Fiscal Year: 2001
    ..These and other central projections of the separate branches of the vestibular nerve will be reexamined in anatomical studies performed on primates to determine whether the sensory projections ..
  12. Stimulation model and experiments for a vestubular prosthesis.
    Gene Fridman; Fiscal Year: 2009
    ..implanted in the semicircular canals of chinchillas indicate that the separation between the branches of the vestibular nerve is too narrow to allow a clean stimulation signal to be delivered separately to each targeted branch of the ..
  13. HUMAN MODEL OF VESTIBULAR DEAFFERENTATION
    Akira Ishiyama; Fiscal Year: 2001
    ..vestibular periphery will be obtained: 1) Is there a dependency of the vestibular neuroepithelium on the vestibular nerve for survival? 2) Reciprocally, is the vestibular nerve dependent on the vestibular hair cells for survival? 3)..
  14. INFORMATION CHANNELS IN THE VESTIBULAR NERVE
    ELLENGENE PETERSON; Fiscal Year: 2000
    ..To understand vestibular control of head movements we need to know the functional components of the vestibular nerve and the role each component plays in the control of posture and gaze...
  15. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..comparisons will be made to data from subjects who underwent surgical destruction of the labyrinth or vestibular nerve in order to determine if complete ablation is necessary or not...
  16. Electrical Stimulation to Restore Vestibular Function
    CHARLES DELLA SANTINA; Fiscal Year: 2007
    ..Because the vestibular nerve should be intact in these patients, selectively applied electrical currents should be able to drive the nerve ..
  17. FUNCTION OF THE EFFERENT VESTIBULAR SYSTEM
    Jay Goldberg; Fiscal Year: 2003
    ..Some information on vestibular inputs to the EVS are best obtained in acute preparations; these experiments will be done in decerebrate chinchillas. ..
  18. PROCESSING OF INFORMATION BY THE VESTIBULOSPINAL SYSTEM
    ROBERT SCHOR; Fiscal Year: 1993
    ..Recordings will be made from single identified neurons at various levels (e.g. vestibular nerve, vestibular and other brainstem relay nuclei)...
  19. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..We also want to know what these doses of gentamicin do to the vestibular part of the inner ear and the vestibular nerve afferents...
  20. Efferent Vestibular Mechanisms
    MEIR PLOTNIK PELEG; Fiscal Year: 2003
    ..Recent work on efferent-mediated responses recorded from vestibular nerve-afferents suggested that the efferent vestibular system (EVS) conveys vestibular input to modify subsequent ..
  21. INTENSITY CODING IN ACOUSTIC AND ELECTRIC HEARING
    Fan Gang Zeng; Fiscal Year: 1999
    ....
  22. NEW METHOD TO IDENTIFY UNILATERAL VESTIBULAR DYSFUNCTION
    Robert Peterka; Fiscal Year: 2002
    ..Experimental results from subjects with different levels of partial unilateral vestibular loss will determine the effectiveness and reliability of the proposed new rotation test. ..
  23. CLINICAL AND GENETIC ANALYSIS OF SCHWANNOMATOSIS
    Mia MacCollin; Fiscal Year: 2001
    ..either associated with the classic tumor suppressor gene syndrome neurofibromatosis 2 (NF2) or without vestibular nerve involvement (schwannomatosis)...
  24. REGENERATION OF THE EIGHTH CRANIAL NERVE
    ANITA NEWMAN; Fiscal Year: 1992
    ..of this project is to investigate in mammals the morphological and functional regenerative capacity of the vestibular nerve following surgical sectioning...
  25. PHYSIOLOGY & ADAPTIVE CONTROL OF OTOLITH/OCULAR REFLEXES
    Richard Clendaniel; Fiscal Year: 2001
    ..b>Vestibular nerve afferents innervating the otoliths cannot distinguish between movements leading to each of these three ..
  26. Galvanic Effects on the Human Vestibuloocular Reflex
    Americo Migliaccio; Fiscal Year: 2007
    ..applicant): The long-term objectives of this project are to better understand the contribution of irregular vestibular nerve afferent fibers to the human vestibulo-ocular reflex (VOR), and to understand the functional impact of ..
  27. Neurophysiology Studies Electrical Stimulation For Vestibular Nerve
    James Phillips; Fiscal Year: 2010
    This project will provide research and development of methods for electrically stimulating the vestibular nerve following loss of function from the vestibular end organs...
  28. Neurophysiology Studies Electrical Stimulation For Vestibular Nerve
    James Phillips; Fiscal Year: 2011
    This project will provide research and development of methods for electrically stimulating the vestibular nerve following loss of function from the vestibular end organs...
  29. BIOCHEMICAL CORRELATE OF VESTIBULAR FUNCTION
    Ruediger Thalmann; Fiscal Year: 1980
    ..a) the cerebellar flocculus; b) the nodulus-uvula; and c) the vestibular endorgans; we will section the vestibular nerve; and we will lesion the commissural vestibular pathways...
  30. Structure-Function Studies of Avian MVN Neurons
    Adria Gottesman Davis; Fiscal Year: 2009
    ..As the basic mechanisms involved in vestibular reflex function are better understood, more effective therapies may be devised to treat vestibular disorders resulting from disease, injury and aging. ..
  31. Advanced Vestibular Evoked Myogenic Potential (VEMP) Screening and Testing System
    EDWARD MISKIEL; Fiscal Year: 2009
    ..as an indirect measure of the functional integrity of the saccule, a portion of the otoliths, the inferior vestibular nerve or other central connections of the saccule...
  32. Eye Movement Studies with a Vestibular Prosthesis
    Michael Saginaw; Fiscal Year: 2006
    ..This investigation will study the vestibular system in guinea pigs and squirrel monkeys by stimulating the vestibular nerve with modulated electrical pulses that contain signals at a variety of frequencies, and characterizing the ..
  33. Motion Sensor Array for Vestibular-deficient Individuals
    Conrad Wall; Fiscal Year: 2005
    ..selected because there is not presently a practical way of providing direct electric stimulation to the human vestibular nerve using implantable devices...
  34. VESTIBULAR AFFERENT AND EFFERENT ACTIVITY
    STEPHEN HIGHSTEIN; Fiscal Year: 1990
    ..will be utilized to determine the synaptic events in hair cells following stimulation of the efferent vestibular nerve. This experiment will be crucial to our understanding of efferent function because of the differential ..
  35. VESTIBULAR AND AUDITORY AFFERENT AND EFFERENT ACTIVITY
    STEPHEN HIGHSTEIN; Fiscal Year: 1993
    ..will be utilized to determine the synaptic events in hair cells following stimulation of the efferent vestibular nerve. This experiment will be crucial to our understanding of efferent function because of the differential ..
  36. Mechanism of Opiate Induced Audiovestibular Dysfunction
    Gail Ishiyama; Fiscal Year: 2006
    ....
  37. Vestibular Influences on Head Direction Cell Activity
    Bill Yates; Fiscal Year: 2004
    ..This work may also provide insights into potential effects of peripheral and central vestibular lesions on spatial cognition in humans. ..
  38. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  39. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  40. QUANTITATIVE MORPHOPHYSIOLOGY OF VESTIBULAR AFFERENTS
    GOLDA KEVETTER; Fiscal Year: 2004
    ..This could prove important for treatment of patients with vestibular disorders, such as those suffering with Meniere's disease or even normal aging. ..
  41. Physiology of vestibulo-thalamic pathways
    Robert McCrea; Fiscal Year: 2005
    ..abstract_text> ..
  42. Methylphenidate & gene expression in the rat brain.
    JOAN BAIZER; Fiscal Year: 2004
    ..abstract_text> ..
  43. Vestibular Compensation During Volitional Head Movements
    SHAWN NEWLANDS; Fiscal Year: 2004
    ..This work is an extension and supplementation of the P.I.'s ongoing career development award project (K-08-DC00182). ..
  44. Vestibular Pathology in Meniere's Disease
    Akira Ishiyama; Fiscal Year: 2007
    ..1) regional total type I, type II, and supporting cell counts in each of the five vestibular endorgans 2) vestibular nerve fiber counts and diameter distribution 3) Scarpa's ganglion neuronal counts and volume distribution...
  45. VESTIBULAR NUCLEUS ACTIVITY IN VESTIBULAR COMPENSATION
    SHAWN NEWLANDS; Fiscal Year: 2003
    ..abstract_text> ..
  46. Herpesviruses in Vestibular Neuritis
    JEFFREY VRABEC; Fiscal Year: 2003
    ..This information can help determine why some individuals with latent virus in the vestibular ganglion develop clinical symptoms due to reactivation and some do not. ..
  47. VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING
    Sergei Yakushin; Fiscal Year: 2002
    ..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..
  48. EFFERENT INNERVATION OF IDENTIFIED VESTIBULAR AFFERENTS
    Anna Lysakowski; Fiscal Year: 2008
    ..The intent is to produce a body of morphological, neurochemical and cell biological knowledge from which physiologically and pharmacologically testable hypotheses can be derived. [unreadable] [unreadable] [unreadable]..
  49. PHYSIOLOGY OF OCULOMOTOR PREMOTOR PATHWAYS
    Robert McCrea; Fiscal Year: 2007
    ..The results should increase our understanding of the central mechanisms that allow clear vision of objects in a 3D environment during passive and active head movements. ..
  50. Regulation of auditory neuron neurite growth by activity
    Marlan Hansen; Fiscal Year: 2008
    ..The results of these studies will provide critical data on the consequences of electrical activity on SGN neurite growth and cochlear innervation. ..
  51. CELLULAR AND MOLECULAR STUDIES OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 2007
    ..The two specific aims of this project are linked in that one drives studies of the the effector pKir2.1 and the second directs studies the msucarinic receptors in the pathway proposed above. ..
  52. MORPHOPHYSIOLOGY OF PRE-NUCLEAR OCULOMOTOR NEURONS
    STEPHEN HIGHSTEIN; Fiscal Year: 2008
    ..abstract_text> ..
  53. Retinoids and Substances of Abuse in HIV-1 Infection
    Walter Royal; Fiscal Year: 2006
    ..These studies will broaden our understanding of the immune effects of retinoid compounds in individuals with HIV infection, and may lead to effective approaches to the treatment of the infection and its complications with vitamin A...
  54. Restoration of postural control after spinal cord injury
    TATIANA DELIAGINA; Fiscal Year: 2008
    ..These experiments will provide insights into the role of descending commands for activation of spinal postural mechanisms, and into the nature of postural dysfunction after SCI. ..
  55. BIOCHEMISTRY OF VESTIBULAR COMPENSATION
    DONALD GODFREY; Fiscal Year: 2001
    ....
  56. In Vitro Analysis of Embryonic Inner Ear Cells
    LYNNE BIANCHI; Fiscal Year: 2002
    ..Together, these experiments will provide information regarding the mechanisms used for organizing normal auditory and vestibular epithelia and may provide insight into means of treating congenital anomalies of the inner ear...
  57. PROCESSING OF BILATERAL INPUTS TO VESTIBULAR NUCLEUS
    Michael Ariel; Fiscal Year: 2002
    ..This project analyzes these bilateral inputs to gain an understanding of their role in the natural processing that results in a normal sense of balance or produces the feeling of vertigo during a pathological condition. ..
  58. VESTIBULAR MECHANISMS IN THE DYNAMICS OF LOCOMOTION
    Theodore Raphan; Fiscal Year: 2006
    ....
  59. DEVELOPMENT OF VESTIBULAR NUCLEI NEURONS
    KENNA PEUSNER; Fiscal Year: 2005
    ..abstract_text> ..
  60. Cerebellar Afferent Integration Studied In Vitro
    Michael Ariel; Fiscal Year: 2007
    ..This in vitro preparation will thereby provide a unique model system for the study of learning and adaptation of motor behaviors. [unreadable] [unreadable]..
  61. VESTIBULAR INFLUENCES ON SPATIAL ORIENTATION
    Richard Lewis; Fiscal Year: 2008
    ..abstract_text> ..
  62. MULTIDIMENSIONAL DYNAMIC OF THE VESTIBULO OCULAR REFLEX
    Theodore Raphan; Fiscal Year: 2008
    ..When the study is completed, we will have a quantitative model of how the vestibular system contributes to maintenance of binocular gaze stability while moving. ..
  63. Function of Vestibular-Nerve Afferent Types
    Timothy Hullar; Fiscal Year: 2008
    ..Findings from this study will allow better understanding of pathologies of the peripheral vestibular system. ..
  64. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    Kenna D Peusner; Fiscal Year: 2010
    ..As we learn more about the pathology induced by vestibular deafferentation at the level of vestibular nuclei neurons, effective therapies can be targeted selectively to improve the clinical management of patients with balance disorders. ..