trigeminal nerve

Summary

Summary: The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the trigeminal ganglion and project to the trigeminal nucleus of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.

Top Publications

  1. ncbi White matter brain and trigeminal nerve abnormalities in temporomandibular disorder
    Massieh Moayedi
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Pain 153:1467-77. 2012
  2. ncbi Compartmental study of T(1) and T(2) in rat brain and trigeminal nerve in vivo
    Mark D Does
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8042, USA
    Magn Reson Med 47:274-83. 2002
  3. ncbi Anatomical and electrophysiological analysis of the trigeminal nerve in a teleost fish, Oncorhynchus mykiss
    Lynne U Sneddon
    Roslin Institute, Welfare Biology, Roslin, Midlothian, UK
    Neurosci Lett 319:167-71. 2002
  4. ncbi Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 SW Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Pain 116:386-95. 2005
  5. ncbi Cerebral activation to intranasal chemosensory trigeminal stimulation
    Julie A Boyle
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Chem Senses 32:343-53. 2007
  6. pmc Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions
    Mei Xu
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Pain 9:1036-48. 2008
  7. ncbi Differences and similarities between atypical facial pain and trigeminal neuropathic pain
    Heli Forssell
    Department of Oral Diseases, University Hospital, PL 52, FIN 20521 Turku, Finland
    Neurology 69:1451-9. 2007
  8. ncbi Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide
    Elsa Fabbretti
    Consiglio Nazionale delle Ricerche, Istituto Nazionale di Fisica della Materia Democritos National Simulation Center, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 26:6163-71. 2006
  9. pmc Magnetic field changes activate the trigeminal brainstem complex in a migratory bird
    Dominik Heyers
    Arbeitsgruppe Neurosensorik Animal Navigation, Institut für Biologie und Umweltwissenschaften, University of Oldenburg, D 26111 Oldenburg, Germany
    Proc Natl Acad Sci U S A 107:9394-9. 2010
  10. pmc Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin
    Manuela Simonetti
    Neurobiology Sector, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    Mol Pain 2:11. 2006

Detail Information

Publications330 found, 100 shown here

  1. ncbi White matter brain and trigeminal nerve abnormalities in temporomandibular disorder
    Massieh Moayedi
    Institute of Medical Science, University of Toronto, Toronto, ON, Canada
    Pain 153:1467-77. 2012
    ..cognitive function in TMD, but it is not known whether there are white matter (WM) abnormalities along the trigeminal nerve (CNV) or in the brain...
  2. ncbi Compartmental study of T(1) and T(2) in rat brain and trigeminal nerve in vivo
    Mark D Does
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8042, USA
    Magn Reson Med 47:274-83. 2002
    The integrated T(1)-T(2) characteristics of rat brain and trigeminal nerve water were studied in vivo using a rapid method for acquiring a series of images that depend on T(1) and T(2) relaxation times...
  3. ncbi Anatomical and electrophysiological analysis of the trigeminal nerve in a teleost fish, Oncorhynchus mykiss
    Lynne U Sneddon
    Roslin Institute, Welfare Biology, Roslin, Midlothian, UK
    Neurosci Lett 319:167-71. 2002
    The trigeminal nerve in the rainbow trout, Oncorhynchus mykiss, was examined for the presence of A-delta and C fibres...
  4. ncbi Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivity
    John K Neubert
    Department of Orthodontics, College of Dentistry, University of Florida, 1600 SW Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
    Pain 116:386-95. 2005
    ..These data reflect an orofacial pain behavior profile that was based on an animal's responses in an operant escape paradigm. This technique allows evaluation of nociceptive processing and modulation throughout the neuraxis...
  5. ncbi Cerebral activation to intranasal chemosensory trigeminal stimulation
    Julie A Boyle
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Chem Senses 32:343-53. 2007
    ..The overlapping pattern of cortical activation for trigeminal and olfactory stimuli is assumed to be due to the intimate connections in the processing of information from the 2 major intranasal chemosensory systems...
  6. pmc Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactions
    Mei Xu
    Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
    J Pain 9:1036-48. 2008
    b>Trigeminal nerve damage often leads to chronic pain syndromes including trigeminal neuralgia, a severely debilitating chronic orofacial pain syndrome...
  7. ncbi Differences and similarities between atypical facial pain and trigeminal neuropathic pain
    Heli Forssell
    Department of Oral Diseases, University Hospital, PL 52, FIN 20521 Turku, Finland
    Neurology 69:1451-9. 2007
    ....
  8. ncbi Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptide
    Elsa Fabbretti
    Consiglio Nazionale delle Ricerche, Istituto Nazionale di Fisica della Materia Democritos National Simulation Center, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 26:6163-71. 2006
    ..This mechanism might contribute to pain sensitization and represents a model of neuronal plasticity in response to a migraine mediator...
  9. pmc Magnetic field changes activate the trigeminal brainstem complex in a migratory bird
    Dominik Heyers
    Arbeitsgruppe Neurosensorik Animal Navigation, Institut für Biologie und Umweltwissenschaften, University of Oldenburg, D 26111 Oldenburg, Germany
    Proc Natl Acad Sci U S A 107:9394-9. 2010
    ..contains putative magnetosensory ferro-magnetic structures, is innervated by the ophthalmic branch of the trigeminal nerve (V1)...
  10. pmc Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotonin
    Manuela Simonetti
    Neurobiology Sector, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
    Mol Pain 2:11. 2006
    ..The characteristics of such receptors after short-term culture were compared with those of ganglia. Furthermore, their modulation by chronically-applied serotonin or NGF was investigated...
  11. ncbi Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGF
    Rashid Giniatullin
    Neurobiology Sector and Italian Institute of Technology Unit, International School for Advanced Studies SISSA, 34014 Trieste, Italy
    Mol Neurobiol 37:83-90. 2008
    ..The different time domains of P2X3 receptor modulation by NGF and CGRP suggest that the therapeutic efficacy of novel antimigraine drugs depends on the time of administration...
  12. ncbi Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia
    M Obermann
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Neurology 69:835-41. 2007
    ..Between the attacks the patient is usually asymptomatic, but a constant dull background pain may persist in some cases. The mechanisms associated with the development of this chronic pain are not well understood...
  13. ncbi Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular pain
    H Imbe
    Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD, USA
    Cells Tissues Organs 169:238-47. 2001
    ..Since deep inputs may be more effective in inducing central neuronal excitation than cutaneous inputs, greater sensory disturbances may occur in pain conditions involving deep tissues than in those involving cutaneous tissues...
  14. ncbi Neuromodulation for depression: invasive and noninvasive (deep brain stimulation, transcranial magnetic stimulation, trigeminal nerve stimulation)
    Ian A Cook
    UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Henry Samueli School of Engineering at UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA Electronic address
    Neurosurg Clin N Am 25:103-16. 2014
    ..update readers on 3 particular interventions: deep brain stimulation, transcranial magnetic stimulation, and trigeminal nerve stimulation...
  15. ncbi Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory map
    Franck Oury
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, UMR 7104, BP 10142, Communaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
    Science 313:1408-13. 2006
    ..Moreover, early Hoxa2 expression in neuroepithelium prevents the trigeminal nerve from ectopically projecting to the cerebellum, whereas late expression in the principal sensory nucleus ..
  16. ncbi Conditioned response to a magnetic anomaly in the Pekin duck (Anas platyrhynchos domestica) involves the trigeminal nerve
    Rafael Freire
    School of Animal and Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, NSW 2650, Australia
    J Exp Biol 215:2399-404. 2012
    ..The trigeminal nerve was anaesthetised by injection of lignocaine hydrochloride 2-3 mm caudal to the medial canthus of each eye, ..
  17. ncbi Determinants for nasal trigeminal detection of volatile organic compounds
    J Enrique Cometto-Muniz
    Chemosensory Perception Laboratory, Department of Surgery, University of California, San Diego, 9500 Gilman Drive, Mail Code 0957, La Jolla, CA 92093 0957, USA
    Chem Senses 30:627-42. 2005
    ....
  18. ncbi Magnetic field perception in the rainbow trout Oncorynchus mykiss: magnetite mediated, light dependent or both?
    Jens Hellinger
    Lehrstuhl für Allgemeine Zoologie und Neurobiologie, Ruhr Universitat Bochum, Bochum, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:593-605. 2012
    ..Inactivation of the ophthalmic branch of the trigeminal nerve by local anaesthesia revealed its role in the perception of intensity/inclination of the magnetic field by ..
  19. ncbi Trigeminal nerve dysfunction after Gamma Knife surgery for trigeminal neuralgia: a detailed analysis
    Shinji Matsuda
    Gamma Knife House, Chiba Cardiovascular Center, Ichihara, Japan
    J Neurosurg 113:184-90. 2010
    ..The incidence of trigeminal nerve dysfunction, such as facial numbness or dysesthesia, has been reported to be higher than previously published,..
  20. ncbi The influence of training on chemosensory event-related potentials and interactions between the olfactory and trigeminal systems
    Andrew Livermore
    School of Social Sciences and Liberal Studies, Charles Sturt University, Bathurst, NSW 2790, Australia
    Chem Senses 29:41-51. 2004
    ..This was supported by a significant decrease of amplitudes of the event-related potentials at frontal recording sites following training with the test odor only..
  21. ncbi Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal system
    Chul Kyu Park
    National Research Laboratory for Pain, Dental Research Institute and Department of Physiology, School of Dentistry, Seoul National University, 28 2 Yeongeon Dong, Chongno Ku, Seoul 110 749, Republic of Korea
    Pain 144:84-94. 2009
    ..Taken together, these results suggest that eugenol may serve as local anesthetics for other pathological pain conditions in addition to its wide use in dental clinic...
  22. ncbi Visualization of vascular compression of the trigeminal nerve with high-resolution 3T MRI: a prospective study comparing preoperative imaging analysis to surgical findings in 40 consecutive patients who underwent microvascular decompression for trigeminal
    Paulo Roberto Lacerda Leal
    Department of Neurosurgery, University Lyon 1, Lyon, France
    Neurosurgery 69:15-25; discussion 26. 2011
    ..High-resolution three-dimensional (3D) magnetic resonance imaging (MRI) has demonstrated its ability to predict fine trigeminal neurovascular anatomy...
  23. ncbi Trigeminal neuralgia associated with an anomalous artery originating from the persistent primitive trigeminal artery
    Yoshitaka Yamada
    Department of Neurosurgery, Brain and Spine Surgery Center, Shiroyama Hospital, Osaka, Japan
    Neurol Med Chir (Tokyo) 46:194-7. 2006
    ..Microvascular decompression surgery disclosed the trigeminal nerve compressed by this AICA variant together with the superior cerebellar artery...
  24. ncbi Frequency of trigeminal nerve injuries following third molar removal
    Richard C Robert
    Department of Oral and Maxillofacial Surgery, University of California, San Francisco 94143 0440, USA
    J Oral Maxillofac Surg 63:732-5; discussion 736. 2005
    ....
  25. ncbi Brainstem mechanisms underlying feeding behaviors
    J P Lund
    Faculty of Dentistry Department of Physiology, McGill University, Montreal, Quebec, Canada
    Curr Opin Neurobiol 8:718-24. 1998
    ..Orofacial sensory feedback, antidromic firing in spindle afferents and intrinsic properties of motoneurons also contribute to the final masticatory motor output...
  26. ncbi Brainstem and trigeminal nerve changes after radiosurgery for trigeminal pain
    Alessandra Gorgulho
    Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Surg Neurol 66:127-35; discussion 135. 2006
    ..To evaluate the significance of radiological changes on follow-up MRIs after SRS for TN...
  27. ncbi Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the rat
    H Alimohammadi
    Department of Biology, Wake Forest University, Winston Salem, NC 27109, USA
    Chem Senses 25:61-6. 2000
    ..to be scattered throughout the nasal epithelium, and arise from the nasopalatine and ethmoid branches of the trigeminal nerve. In the present study, the effects of nicotinic acetylcholine receptor (nAChR) blockers on ethmoid nerve ..
  28. ncbi High spatiotemporal resolution imaging of the neurovascular response to electrical stimulation of rat peripheral trigeminal nerve as revealed by in vivo temporal laser speckle contrast
    Nan Li
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Neurosci Methods 176:230-6. 2009
    ..Dural vessels enlarged by 40+/-8% and the blood velocity increased by 50+/-5%. The method described here could be very useful in understanding and studying disorders in the neurovascular system...
  29. pmc TRPM5-expressing microvillous cells in the main olfactory epithelium
    Weihong Lin
    Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
    BMC Neurosci 9:114. 2008
    ..Here we examined the morphology and immunocytochemical properties of these microvillous-like cells using immunocytochemical methods...
  30. ncbi Olfactory/trigeminal interactions in nasal chemoreception
    Gerard Brand
    Laboratoire de Neurosciences, Universite de Franche Comte, Place Leclerc, 25000 Besancon, France
    Neurosci Biobehav Rev 30:908-17. 2006
    ..However, several structural, functional and methodological questions remain unsolved in the field of olfactory/trigeminal interactions and deserve further research...
  31. ncbi Trigeminocardiac reflex. A clinical phenomenon or a new physiological entity?
    B Schaller
    Max Planck Institute for Neurological Research, Gleueler Strasse 50, 50931 Cologne, Germany
    J Neurol 251:658-65. 2004
    ..hypotension, apnea or gastric hypermotility during stimulation of any of the sensory branches of the trigeminal nerve. The sensory nerve endings of the trigeminal nerve send neuronal signals via the Gasserian ganglion to the ..
  32. pmc Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signals
    Marco Tizzano
    Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, CO 80045, USA
    Proc Natl Acad Sci U S A 107:3210-5. 2010
    ..Detection of such irritants by the trigeminal nerve evokes protective reflexes, including sneezing, apnea, and local neurogenic inflammation of the mucosa...
  33. ncbi Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats
    Yoshiyuki Tsuboi
    Department of Physiology, School of Dentistry, Nihon University, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Tokyo 101 8310, Japan
    Pain 111:323-34. 2004
    ....
  34. ncbi Outcome of trigeminal nerve section in the treatment of chronic cluster headache
    R G Jarrar
    Departments of Neurology, Mayo Clinic, Rochester, MN, USA
    Neurology 60:1360-2. 2003
    ..The authors followed 17 patients with intractable chronic cluster headache who underwent trigeminal nerve section...
  35. ncbi Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuli
    Thomas Hummel
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
    Int J Psychophysiol 47:147-58. 2003
    ..g. induced by environmental agents...
  36. pmc Randomized controlled trial of trigeminal nerve stimulation for drug-resistant epilepsy
    Christopher M DeGiorgio
    Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Neurology 80:786-91. 2013
    To explore the safety and efficacy of external trigeminal nerve stimulation (eTNS) in patients with drug-resistant epilepsy (DRE) using a double-blind randomized controlled trial design, and to test the suitability of treatment and ..
  37. ncbi Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nerves
    V Busch
    Department of Neurology, University of Regensburg, Regensburg, Germany
    Cephalalgia 27:1206-14. 2007
    ....
  38. ncbi Trigeminal neuralgia due to multiple sclerosis: ultrastructural findings in trigeminal rhizotomy specimens
    S Love
    Department of Neuropathology, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK
    Neuropathol Appl Neurobiol 27:238-44. 2001
    ..The demyelination and associated juxtaposition of axons may therefore account for key aspects of the pathogenesis of trigeminal neuralgia...
  39. ncbi Trigeminal nerve stimulation: seminal animal and human studies for epilepsy and depression
    Christopher M DeGiorgio
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neurosurg Clin N Am 22:449-56, v. 2011
    ..In humans thus far the technique has been applied noninvasively, and is termed external trigeminal nerve stimulation (eTNSTM).
  40. ncbi Neural coding of stimulus concentration in the human olfactory and intranasal trigeminal systems
    M Bensafi
    Universite Claude Bernard, Lyon, Laboratoire de Neurosciences Sensorielles, Comportement, Cognition, UMR 5020, Institut Federatif des Neurosciences de Lyon, IFR19, CNRS, Lyon, France
    Neuroscience 154:832-8. 2008
    ..Taken together, these results suggest separate but overlapping neural networks involved in encoding stimulus intensity in the two chemosensory systems...
  41. pmc Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitro
    Brian D Gulbransen
    Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
    J Neurophysiol 99:2929-37. 2008
    ..alpha-gustducin, PLCbeta2, and TRPM5, leading to speculation that SCCs are the receptor cells that mediate trigeminal nerve responses to bitter taste receptor ligands...
  42. pmc Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve root
    Min Ji Kim
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, South Korea
    Mol Pain 8:16. 2012
    In our present study, we studied the role of demyelination of the trigeminal nerve root in the development of prolonged nociceptive behavior in the trigeminal territory.
  43. ncbi Autogenous grafts/allografts/conduits for bridging peripheral trigeminal nerve gaps
    Larry M Wolford
    Department of Oral and Maxillofacial Surgery, Texas A and M University Health Science Center, Baylor College of Dentistry, Dallas, TX, USA
    Atlas Oral Maxillofac Surg Clin North Am 19:91-107. 2011
    ..However, more research studies using these materials for TN repairs are essential to validate the superiority of these procedures...
  44. ncbi Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells
    Makoto Ohmoto
    Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Mol Cell Neurosci 38:505-17. 2008
    ..Thus, the t1r3-WGA transgenic mice revealed the sweet/umami gustatory pathways from taste receptor cells and the trigeminal neural pathway from solitary chemoreceptor cells...
  45. ncbi An animal model for trigeminal neuralgia by compression of the trigeminal nerve root
    Dao Shu Luo
    Department of Anatomy, Histology and Embryology, Basic Medical College, Fujian Medical University, Fuzhou, China
    Pain Physician 15:187-96. 2012
    Microvascular compression of the trigeminal nerve root is a major cause of most trigeminal neuralgia (TN) in patients; however, no reliable animal model to further study the pathogenesis of TN currently exists.
  46. ncbi Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulation
    E E Fanselow
    Departments of Neurobiology and Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 20:8160-8. 2000
    ..Here, we report that stimulation of another cranial nerve, the trigeminal nerve, can also cause cortical and thalamic desynchronization, resulting in a reduction of seizure activity in ..
  47. ncbi Brain activity during stimulation of the trigeminal nerve with noxious heat
    Reny de Leeuw
    Orofacial Pain Center, College of Dentistry, University of Kentucky, Lexington, KY 40536 0297, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:750-7. 2006
    The aim of this study was to observe areas of brain activation with painful hot stimulation to the trigeminal nerve.
  48. ncbi A rat model of radiofrequency ablation of trigeminal innervation via a ventral approach with stereotaxic surgery
    Edward K Wong
    Ophthalmology, University of California, Med Surge I, Room 118, Irvine 92697 4375, USA
    Exp Eye Res 79:297-303. 2004
    ..The purpose of this study was to create a rat model for neurotrophic keratopathy by denervating the trigeminal nerve through a ventral approach with stereotaxic surgery...
  49. ncbi Trigeminal nerve palsy in nasopharyngeal carcinoma: correlation between clinical findings and magnetic resonance imaging
    Chunyan Cui
    Imaging Diagnosis and Interventional Center, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, People s Republic of China
    Head Neck 31:822-8. 2009
    Our aim was to document the relationship between clinical and MRI evidence of trigeminal nerve involvement.
  50. ncbi Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotine
    J M Dessirier
    Section of Neurobiology, Physiology and Behavior, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
    Physiol Behav 73:25-36. 2001
    ..Repeated application of menthol at the same short ISI was then resumed, and resulted in a significant mean increase in irritant intensity consistent with stimulus-induced recovery (SIR)...
  51. ncbi Iatrogenic injury to oral branches of the trigeminal nerve: records of 449 cases
    Søren Hillerup
    Department of Oral and Maxillofacial Surgery, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Clin Oral Investig 11:133-42. 2007
    The aims of this study were threefold: (1) to describe iatrogenic lesions to oral branches of the trigeminal nerve, signs and symptoms, and functional status, (2) to report on a simple neurosensory examination method, and (3) to discuss ..
  52. ncbi Compartmental study of diffusion and relaxation measured in vivo in normal and ischemic rat brain and trigeminal nerve
    M D Does
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8042, USA
    Magn Reson Med 43:837-44. 2000
    The correlation between the apparent diffusion coefficient (ADC) and T(2) of water in rat brain and trigeminal nerve was investigated using a hybrid diffusion-weighted-CPMG imaging sequence...
  53. ncbi Clinical evaluation of targeting accuracy of gamma knife radiosurgery in trigeminal neuralgia
    Nicolas Massager
    Gamma Knife Center and Department of Neurosurgery, University Hospital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
    Int J Radiat Oncol Biol Phys 69:1514-20. 2007
    ..We also studied the applied radiation dose within the area of focal contrast enhancement on the trigeminal nerve root following radiosurgery.
  54. ncbi Species differences in the reflex effects of lingual afferent nerve stimulation on lip blood flow and arterial pressure
    S Koeda
    Department of Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, 980 8575 Sendai, Japan
    J Comp Physiol B 173:629-36. 2003
    ..Thus, species variability exists in the sympathetic-mediated systemic arterial blood pressure changes and parasympathetic-mediated lip blood flow responses themselves, and in the relationship between them...
  55. ncbi Trigeminal nerve stimulation in major depressive disorder: first proof of concept in an open pilot trial
    Lara M Schrader
    David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Epilepsy Behav 22:475-8. 2011
    Modulation of brain activity via trigeminal nerve stimulation is an emerging therapy in drug-resistant epilepsy...
  56. ncbi Focal enhancement of cranial nerve V after radiosurgery with the Leksell gamma knife: experience in 15 patients with medically refractory trigeminal neuralgia
    R A Alberico
    Departments of Diagnostic Radiology (R.A.A.) and Neurosurgery (R.A.F, Roswell Park Cancer Institute, Buffalo, NY
    AJNR Am J Neuroradiol 22:1944-8. 2001
    ..No correlation of enhancement with treatment response or time to follow-up existed (P >.05). CONCLUSION: The trigeminal nerve often enhances at the target site after radiosurgery...
  57. ncbi Persistence of attacks of cluster headache after trigeminal nerve root section
    Manjit S Matharu
    Headache Group, Institute of Neurology, University College London, UK
    Brain 125:976-84. 2002
    ..We report a patient with a trigeminal nerve section who continued to have attacks...
  58. ncbi Histologic analysis of a human trigeminal nerve after failed stereotactic radiosurgery: case report
    Andrew B Foy
    Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Surg Neurol 68:655-8; discussion 658-9. 2007
    ..However, little is known about the mechanism of pain relief after trigeminal neuralgia radiosurgery. We report the histologic findings of a human trigeminal nerve after failed radiosurgery for trigeminal neuralgia.
  59. ncbi Trigeminal nerve injuries after mandibular implant placement--practical knowledge for clinicians
    Frederick Hegedus
    Department of Oral and Maxillofacial Surgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Int J Oral Maxillofac Implants 21:111-6. 2006
    Endosseous mandibular implant placement can result in injuries to the peripheral branches of the trigeminal nerve even with the most careful preoperative planning and intraoperative technique...
  60. ncbi Trigeminal activation using chemical, electrical, and mechanical stimuli
    E Iannilli
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, Dresden, Germany
    Pain 139:376-88. 2008
    ..proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response...
  61. ncbi The trigeminal nerve. Part IV: the mandibular division
    W E Shankland
    Cranio 19:153-61. 2001
    The mandibular or third division of the trigeminal nerve is the largest of the three divisions. It is considered a mixed nerve. That is, like the ophthalmic and maxillary divisions, the mandibular conveys afferent fibers...
  62. ncbi Trigemino-cardiac reflex: the trigeminal depressor responses during skull base surgery
    Qingli Meng
    Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan, Shandong, PR China
    Clin Neurol Neurosurg 110:662-6. 2008
    ..To observe and analyze the occurrence and management of the trigemino-cardiac reflex (TCR) defined as the phenomenon of abrupt drops in heart rate (HR) and blood pressure during skull base surgery...
  63. ncbi Trigeminal nerve stimulation for epilepsy
    Christopher M DeGiorgio
    Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, USA
    Neurology 61:421-2. 2003
  64. ncbi Trigeminal nerve injury associated with injection of local anesthetics: needle lesion or neurotoxicity?
    Søren Hillerup
    Rigshospitalet and Dental School, University of Copenhagen, Denmark
    J Am Dent Assoc 142:531-9. 2011
    ..The authors used comprehensive national registry and clinical data to conduct a study of adverse drug reactions (ADRs), in particular neurosensory disturbance (NSD), associated with local anesthetics used in dentistry..
  65. ncbi Imaging the trigeminal nerve
    Alexandra Borges
    Radiology Department, Instituto Portugues de Oncologia Francisco Gentil, Centro de Lisboa, Rua Prof Lima Basto, 1093, Lisboa, Portugal
    Eur J Radiol 74:323-40. 2010
    Of all cranial nerves, the trigeminal nerve is the largest and the most widely distributed in the supra-hyoid neck. It provides sensory input from the face and motor innervation to the muscles of mastication...
  66. ncbi Trigeminal-parabrachial connections: possible pathway for nociception-induced cardiovascular reflex responses
    G V Allen
    Faculty of Medicine, Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Brain Res 715:125-35. 1996
    ..8 +/- 3.5 S.E.M.) subnuclei. The results demonstrate that nociceptive dental input received by the three subnuclei of the spinal trigeminal nucleus, particularly the subnucleus caudalis, is relayed to the lateral parabrachial nucleus...
  67. ncbi Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trial
    Christopher M DeGiorgio
    UCLA Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Epilepsia 47:1213-5. 2006
    The safety and preliminary efficacy of trigeminal nerve stimulation (TNS) for epilepsy was evaluated in a pilot feasibility study of transcutaneous stimulation of the infraorbital and supraorbital branches of the trigeminal nerve...
  68. ncbi Acute and long-term safety of external trigeminal nerve stimulation for drug-resistant epilepsy
    Juliana Pop
    Department of Neurology, Olive View Internal Medicine Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Epilepsy Behav 22:574-6. 2011
    b>Trigeminal nerve stimulation (TNS) is a novel therapy for drug-resistant epilepsy...
  69. ncbi Utility of magnetic resonance cisternography using three-dimensional fast asymmetric spin-echo sequences with multiplanar reconstruction: the evaluation of sites of neurovascular compression of the trigeminal nerve
    Tatsurou Tanaka
    Department of Dental Radiology, Kyushu Dental College, Kitakyushu, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:215-25. 2005
    ....
  70. ncbi Responses to olfactory and intranasal trigeminal stimuli: relation to the respiratory cycle
    A Haehner
    Department of Otorhinolaryngology, University of Dresden Medical School, 01307 Dresden, Fetscherstr 74, Germany
    Neuroscience 175:178-83. 2011
    ..These data indicate on an electrophysiological level that there is priming of both olfactory and trigeminally mediated sensations in relation to the respiratory cycle...
  71. ncbi Trigeminal nerve-mediated reflex arterial blood pressure decrease and vasodilatation in lower lip of the rabbit
    Makoto Yasuda
    Dento oral Anesthesiology, Tohoku University Graduate School of Dentistry, 980 8575 Sendai, Japan
    Brain Res 987:59-66. 2003
    ..In contrast, the evoked decrease in contralateral LBF was proportional to the decrease in arterial blood pressure, suggesting that the former was secondary to the latter...
  72. ncbi Application of a pro-inflammatory agent to the orbital portion of the rat infraorbital nerve induces changes indicative of ongoing trigeminal pain
    Rafael Benoliel
    The Department of Oral Diagnosis, Hadassah School of Dental Medicine, The Hebrew University, Jerusalem, Israel
    Pain 99:567-78. 2002
    ..This model of inflammation-induced neuropathic pain is highly applicable to the study of neuroinflammatory orofacial pain...
  73. ncbi BOLD responses to trigeminal nerve stimulation
    Nathalie Just
    Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    Magn Reson Imaging 28:1143-51. 2010
    ..investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve ..
  74. ncbi Clinical characteristics of trigeminal nerve injury referrals to a university centre
    A B G Tay
    Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina at Chapel Hill, CB 7450, Chapel Hill, NC 27599 7450, USA
    Int J Oral Maxillofac Surg 36:922-7. 2007
    The aim of this retrospective study was to determine the aetiology and characteristics of trigeminal nerve injuries referred to a university centre with nerve injury care...
  75. ncbi Radiosurgery for trigeminal neuralgia: is sensory disturbance required for pain relief?
    Bruce E Pollock
    Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Neurosurg 105:103-6. 2006
    ..Over the past 15 years stereotactic radiosurgery has become an accepted surgical option for patients with medically unresponsive trigeminal neuralgia (TN). The mechanism whereby radiosurgery causes pain relief remains unclear...
  76. ncbi Intranasal chemosensory function of the trigeminal nerve and aspects of its relation to olfaction
    Thomas Hummel
    Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
    Int Arch Occup Environ Health 75:305-13. 2002
    ..The review outlines characteristics of the intranasal trigeminal chemosensory system. In addition, it provides selective comparisons of the trigeminal and olfactory systems, the two of which interact at multiple levels...
  77. ncbi Heterotopic ischemic pain attenuates somatosensory evoked potentials induced by electrical tooth stimulation: diffuse noxious inhibitory controls in the trigeminal nerve territory
    Keiko Fujii
    Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Japan
    Eur J Pain 10:495-504. 2006
    ..electrical tooth stimulation, triggering diffuse noxious inhibitory controls (DNIC) and after-effects in the trigeminal nerve territory...
  78. ncbi Inflammatory pseudotumor of the trigeminal nerve: a neoplastic mimic you do not want to miss
    J G Seol
    Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
    AJNR Am J Neuroradiol 30:1941-3. 2009
    ..We present a case of pseudotumor originating from the trigeminal nerve in a patient who presented with headache and facial numbness...
  79. ncbi Subjects with congenital anosmia have larger peripheral but similar central trigeminal responses
    J Frasnelli
    Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
    Cereb Cortex 17:370-7. 2007
    Most odorants not only stimulate olfactory receptor neurons but also activate the intranasal trigeminal nerve. The simultaneous activation of the olfactory and the trigeminal system leads to an interaction in the brain...
  80. ncbi Chemosensory event-related potentials change with age
    T Hummel
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Electroencephalogr Clin Neurophysiol 108:208-17. 1998
    ..The age-related decrease of CSERP amplitudes appeared to follow a different time course for responses to trigeminal and olfactory stimulants...
  81. ncbi A new animal model of trigeminal neuralgia produced by administration of cobra venom to the infraorbital nerve in the rat
    Jian Xiong An
    Department of Anesthesiology, Central South University Xiangya Hospital, Changsha, China
    Anesth Analg 113:652-6. 2011
    ..We have developed an experimental animal model for trigeminal neuralgia using a technique of injecting cobra venom into the infraorbital nerve (ION) trunk...
  82. ncbi Effectiveness of cervical sympathetic ganglia block on regeneration of the trigeminal nerve following transection in rats
    Naotoshi Hanamatsu
    Department of Anesthesiology, School of Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
    Reg Anesth Pain Med 27:268-76. 2002
    Stellate ganglion block (SGB) is one treatment option for human trigeminal nerve injury...
  83. ncbi TRPV1 receptors and nasal trigeminal chemesthesis
    Wayne L Silver
    Department of Biology, Wake Forest University, Winston Salem, NC 27106, USA
    Chem Senses 31:807-12. 2006
    The trigeminal nerve responds to a wide variety of irritants...
  84. pmc Solitary chemoreceptor cell survival is independent of intact trigeminal innervation
    Brian Gulbransen
    Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, School of Medicine University of Colorado Denver, Aurora, Colorado 80045, USA
    J Comp Neurol 508:62-71. 2008
    ..2003] Proc Natl Acad Sci USA 100:8981-8986). SCCs are innervated by peptidergic trigeminal nerve fibers (Finger et al...
  85. ncbi SUNCT: bilateral hypothalamic activation during headache attacks and resolving of symptoms after trigeminal decompression
    Till Sprenger
    Department of Neurology, Technische Universitat Munchen, Klinikum rechts der Isar, Moehlstr 28, D 81675 Munich, Germany
    Pain 113:422-6. 2005
    ..Interestingly, this patient became completely pain free after surgical decompression of the ipsilateral trigeminal nerve. We hypothesize that in this case with a central predisposition for trigeminal autonomic cephalgias, a ..
  86. ncbi Management of patients with trigeminal nerve injuries after mandibular implant placement
    Richard A Kraut
    Oral and Maxillofacial Surgery, Montefiore Medical Center, Department of Dentistry, Bronx, NY 10467, USA
    J Am Dent Assoc 133:1351-4. 2002
    ..All dentists who place mandibular implants should be aware of the appropriate early management of these injuries, as well as the appropriate time to refer patients with these injuries to a microneurosurgeon...
  87. ncbi Cavernous malformation of the trigeminal nerve manifesting with trigeminal neuralgia: case report
    Vivek R Deshmukh
    Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
    Neurosurgery 56:E623; discussion E623. 2005
    We describe a patient with a cavernous malformation within the trigeminal nerve at the nerve root entry zone who presented with trigeminal neuralgia.
  88. ncbi Microvascular decompression of the trigeminal nerve in the treatment of SUNCT and SUNA
    Max Williams
    Department of Neurology, Gold Coast Hospital, Southport, Australia
    J Neurol Neurosurg Psychiatry 81:992-6. 2010
    ....
  89. ncbi Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptide
    L Edvinsson
    Department of Internal Medicine, Lund University Hospital, Sweden
    J Auton Nerv Syst 70:15-22. 1998
    ..These data suggest that although NOS is seen in several trigeminal ganglion cells and coexists with CGRP in a subpopulation of the sensory neurons, its role in trigeminally mediated vasodilatation was not significant...
  90. ncbi Event-related fMRI with painful electrical stimulation of the trigeminal nerve
    Sabine Fitzek
    Department of Neurology, Friedrich Schiller University Jena, Jena, Germany
    Magn Reson Imaging 22:205-9. 2004
    ..The aim of the present study was to develop and implement painful stimulation of the trigeminal nerve, which can be applied with event-related paradigms by using MRI...
  91. ncbi Peripheral mechanisms for the initiation of pain following trigeminal nerve injury
    Peter P Robinson
    Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA United Kingdom
    J Orofac Pain 18:287-92. 2004
    Injury to a branch of the trigeminal nerve may lead to the development of chronic pain in the affected area...
  92. ncbi Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injury
    Zheng Gen Piao
    Department of Physiology, College of Dentistry and Dental Research Institute, Seoul National University, Seoul 110 749, Republic of Korea
    Pain 121:219-31. 2006
    ..These results suggest that glial activation in MDH plays an important role in the development of neuropathic pain and activation of p38 MAPK in hyperactive microglia contributes to pain hypersensitivity in IAMNT model...
  93. ncbi Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study
    Delphine Magis
    Headache Research Unit, Department of Neurology, Liege University, CHR Citadelle, Liege, Belgium
    Lancet Neurol 6:314-21. 2007
    ..Occipital nerve stimulation (ONS) is a new, safe strategy for intractable headaches. We undertook a prospective pilot trial of ONS in drCCH to assess clinical efficacy and pain perception...
  94. ncbi Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model
    Hayrunnisa Bolay
    Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 8:136-42. 2002
    Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms remain controversial and poorly understood...
  95. ncbi Interactions between olfaction and the trigeminal system: what can be learned from olfactory loss
    Johannes Frasnelli
    Cognitive Neuroscience Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
    Cereb Cortex 17:2268-75. 2007
    The olfactory and the trigeminal systems have a close relationship. Most odorants also stimulate the trigeminal nerve. Further, subjects with no sense of smell exhibit a decreased trigeminal sensitivity with unclear underlying mechanisms...
  96. ncbi The trigemino-cervical reflex in normal subjects
    I Milanov
    St Naum University Neurological Hospital, Sofia, Bulgaria
    Funct Neurol 16:129-34. 2001
    ..In conclusion, the trigemino-cervical reflex may be most easily obtained from the relaxed sternocleidomastoid muscle after supraorbital nerve stimulation...
  97. ncbi The fine branches of the human trigeminal nerve
    M Yu Uryvaev
    Department of Human Anatomy, Moscow State Medical Stomatological University, Russia
    Neurosci Behav Physiol 38:157-60. 2008
    ..The results showed that numerous branches of diameter 50-150 microm ran directly from the trigeminal nerve, more from the outer and less from the deeper surface, innervating the walls of the trigeminal cavity...
  98. pmc Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve root
    Hye J Jeon
    Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea
    Mol Pain 7:46. 2011
    ..in the modulation of nociceptive behavior and p-p38 MAPK expression in a rat model with compression of the trigeminal nerve root...
  99. ncbi Therapeutic implications of central and peripheral neurologic mechanisms in migraine
    Christian Waeber
    Neuroscience Center, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
    Neurology 61:S9-20. 2003
  100. ncbi Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compression
    S Love
    Department of Neuropathology, Frenchay Hospital, Bristol, UK
    Brain Pathol 8:1-11; discussion 11-2. 1998
    ..The partly aberrant nature of the myelination within the region of vascular compression may contribute to the persistence of symptoms in some patients after decompressive surgery...
  101. ncbi Ultrastructural analysis of a putative magnetoreceptor in the beak of homing pigeons
    Gerta Fleissner
    Zoologisches Institut, J W Goethe Universität Frankfurt am Main, Siesmayerstrasse 70, D 60054 Frankfurt am Main, Germany
    J Comp Neurol 458:350-60. 2003
    ....

Research Grants65

  1. Intranasal CNS delivery of drugs against organophosphorous threat agents
    ARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013
    ..involves possible transport through the neuroepithelial cells of olfactory epithelium as well as through trigeminal nerve pathways...
  2. Nicotine Modulation of Parasympathetic Cardiac Neurons
    David Mendelowitz; Fiscal Year: 2013
    ..Electrical or mechanical stimulation of the trigeminal nerve evokes a dramatic decrease in heart rate in animals including man, and has often been termed the `..
  3. Satellite Glial Cells
    Luc Jasmin; Fiscal Year: 2013
    ..the contribution of SGC-specific genes to the control of neuronal excitability and sensory behavior following trigeminal nerve injury...
  4. Defining Target Contribution to Orofacial Pain by Antisense Oligonucleotides
    Zhigang Luo; Fiscal Year: 2009
    ..in vitro biochemical studies and non-orofacial, nerve injury-induced chronic pain models, we hypothesize that trigeminal nerve injury leads to altered expression of the calcium channel alpha-2-delta-1 subunit (Cava2d1) and ..
  5. Trigeminal Nerve Stimulation for Epilepsy
    Christopher DeGiorgio; Fiscal Year: 2012
    ..to the ultimate FDA approval and commercialization of a new minimally invasive treatment for epilepsy, Trigeminal Nerve Stimulation...
  6. NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNING
    Joyce Keifer; Fiscal Year: 2013
    ..stimuli as in behaving animals we use paired stimulation of the auditory nerve (the "tone" CS) with the trigeminal nerve (the "airpuff" US) that results in burst discharge in the abducens nerve, which controls blinking in this ..
  7. Development of a Mouse Trigeminal Pain Model
    ANDREW RUSSO; Fiscal Year: 2009
    ..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa...
  8. Netrin5 in Mammalian Neurodevelopment
    Robert W Burgess; Fiscal Year: 2013
    ..points and dorsal root entry zones in the mouse embryonic spinal cord, and is associated with the sensory trigeminal nerve and possibly other cranial nerves...
  9. Aberrant Blink Reflex Motor Learning in a Rat Model of Parkinsons Disease
    JAIME A KAMINER; Fiscal Year: 2013
    ..inducing protocols involving the presentation of high frequency stimulation to the supraorbital branch of the trigeminal nerve. These data will demonstrate the degree of disruption for short-term plasticity and long term learning of ..
  10. Nasal solitary chemosensory cells linking irritation to inflammation
    Marco Tizzano; Fiscal Year: 2013
    ..solitary chemosensory cells (SCCs) which are specialized chemo-sensitive epithelial cells innervated by the trigeminal nerve. SCCs express elements of the bitter taste transduction cascade, i.e...
  11. International collaborative research to develop quantitive sensory testing guidel
    Mark Drangsholt; Fiscal Year: 2009
    ..Quantitative sensory testing (QST) of the trigeminal nerve has helped elucidate the mechanisms of a subset of these pain conditions...
  12. Civamide Nasal Spray for the Treatment of Postherpetic Neuralgia of the Trigemina
    Scott B Phillips; Fiscal Year: 2013
    ..of concept clinical study of Civamide Nasal Spray for the treatment of postherpetic neuralgia (PHN) of the trigeminal nerve [(TN), a severely disabling facial pain syndrome]...
  13. Gene Therapy for Nerve Injury
    Luc Jasmin; Fiscal Year: 2010
    ..Oral, facial, and head pain from trigeminal nerve dysfunction is a common clinical problem and one of the most challenging to treat...
  14. A novel pathway mediating the development of chronic orofacial neuropathic pain
    Oswald Steward; Fiscal Year: 2013
    ..Based on our preliminary data from a trigeminal nerve injury model and in non-orofacial pain models, we hypothesize that trigeminal nerve injury induced ..
  15. Nasal Solitary Chemoreceptor Cells: Detection of Pathogenic Bacteria
    Sue Kinnamon; Fiscal Year: 2013
    ..of specialized chemoreceptor cells (solitary chemosensory cells) that form functional contacts with the trigeminal nerve. Activation of the trigeminal nerve either directly by irritants or through the agency of these cells evokes ..
  16. IONTOPHORESIS OF ANTIVIRALS TO HERPES EYE INFECTIONS
    James Hill; Fiscal Year: 1980
    ..from the homogenates of the trigeminal ganglia, superior cervical ganglia, the ophthalmic branch of the trigeminal nerve, and the root-entry zone of the trigeminal nerve...
  17. TRIGEMINOHYPOTHALAMIC TRACT
    Rami Burstein; Fiscal Year: 1999
    ..painful stimuli of the face suggests that sensory information that originates in structures Innervated by the trigeminal nerve is available to these neurons...
  18. Development of an Implantable Trigeminal Nerve Stimulation System for Drug Resist
    Christopher DeGiorgio; Fiscal Year: 2013
    ..b>Trigeminal Nerve Stimulation (TNS) is an emerging neuromodulation therapy for DRE, which has unique advantages over other ..
  19. Primary Afferent Transmission in the Trigeminal Dorsal Horn
    TALLY MARIE MILNES; Fiscal Year: 2013
    ..to investigate the cellular mechanisms underlying synaptic transmission between the central terminals of the trigeminal nerve (trigeminal afferents) and neurons located in the spinal trigeminal nucleus caudalis (Vc), a brainstem region ..
  20. TRIGGERING MECHANISMS FOR MIGRANINE HEADACHE
    MOSKOWITZ MICHAEL; Fiscal Year: 2006
    ..Although the headache phase involves cerebral and extracerebral blood vessels and perivascular trigeminal nerve fibers, the triggering mechanisms of migraine are not known...
  21. Novel Operant Thermal Assessments of Orofacial Pain
    JOHN NEUBERT; Fiscal Year: 2007
    ..be investigated: Aim #1, to evaluate an operant model of thermal hyperalgesia and allodynia for evaluating trigeminal nerve mediated pain; and Aim #2, to investigate the effects of opioid and non-opioid mediated analgesia on thermal ..
  22. MOLECULAR GENETICS OF SENSORY GANGLIA DEVELOPMENT
    Alexander Schier; Fiscal Year: 2007
    ..Injuries and malformations of the trigeminal nerve are clinically and cosmetically devastating and are often associated with trigeminal neuralgia, a severe and ..
  23. Recombinant Herpes Injection into Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2004
    ..In so doing, we hope to provide initial support for what may be a new long-lasting treatment for trigeminal nerve-related pain.
  24. Roles of neurotrophic factors in dental pulp innervation
    Christopher Nosrat; Fiscal Year: 2003
    ..It is anatomically well-defined and becomes richly innervated by trigeminal nerve fibers...
  25. VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSION
    David Busija; Fiscal Year: 2001
    ..arterioles via mechanisms intrinsic to the vessel wall--activation of perivascular fibers associated with the trigeminal nerve, or by an endothelium-dependent pial arteriolar dilation arising secondary to dilation of intracortical ..
  26. Chronic Compression of the Trigeminal Ganglia
    David Yeomans; Fiscal Year: 2009
    ..In the majority of cases, the pain can be traced to chronic compression of the trigeminal nerve roots by a blood vessel, leading to demyelination of the compressed roots...
  27. AGE-RELATED CHANGE IN TRIGEMINAL GANGLION EXCITABILITY
    Thomas Baumann; Fiscal Year: 2003
    ..While vascular compression of the trigeminal nerve root appears to be the main element in the etiology of trigeminal neuralgia, an age-related change in the ..
  28. BEHAVIORAL CORRELATES OF NEURAL PLASTICITY
    V Ramachandran; Fiscal Year: 2001
    ..We will also perform 3 additional experiments. First, we will examine patients after section of the trigeminal nerve (ganglion) to find out if they refer sensations from the hand to the face...
  29. NERVE-MUSCLE INTERACTIONS DURING JAW MUSCLE DEVELOPMENT
    CHARLES WIDMER; Fiscal Year: 2002
    ..of masticatory muscle fibers and the muscle fiber distribution within each jaw muscle are dependent on trigeminal nerve-muscle interactions...
  30. OROFACIAL PAIN RESEARCH CENTER
    Glenn Clark; Fiscal Year: 1990
    ..One of these projects involve an animal model. This project is on herpes simplex virus and its effect on trigeminal nerve function in guinea pigs...
  31. UTILIZATION OF TRIGEMINAL EVOKED POTENTIALS IN DENTISTRY
    CHARLES WIDMER; Fiscal Year: 1990
    ..electrophysiological techniques to investigate and evaluate the peripheral and central pathways of the trigeminal nerve and to apply these techniques to dental disorders such as trigeminal nerve injury...
  32. EFFECT OF UNTRAOCULAR GRAFTING ON THE CORNEA
    Lawrence Borges; Fiscal Year: 1992
    ..In a pilot study we have examined two animal models of neuroparalytic keratitis: One as a result of trigeminal nerve transection and the other as a consequence of systemic administration of capsaicin (a drug known to destroy ..
  33. MOLECULAR BASIS OF ACTION OF NOVEL SENSORY IRRITANTS
    Igor Mezine; Fiscal Year: 1999
    ..using the digital fluorescent determination of intracellular calcium in trigeminal sensory neurons in vitro, trigeminal nerve recordings in vivo and in artificial lipid bilayers...
  34. DENTAL SENSORY MECHANISMS
    Thomas Baumann; Fiscal Year: 1999
    ..The hydrodynamic theory implies the presence of mechanosensitive transducer elements in trigeminal nerve endings. We hypothesize that the transducer elements are mechanosensitive ion channels...
  35. EARLY CHANGES IN POTENTIAL BRAIN TUMOR TISSUE
    SHIRLEY SOUKUP; Fiscal Year: 1980
    ..Our main objective is to study early stages of oncogenesis in neural target tissues. Brain and trigeminal nerve ganglia are removed from rats treated transplacentally with ENU...
  36. NERVE GROWTH FACTOR AND OROFACIAL NEUROPATHIC PAIN
    Leigh Anderson; Fiscal Year: 2001
    ..Finally, clinical studies suggest that lesions of the trigeminal nerve lead to chronic pain conditions that differ from those of segmental nerves (e.g...
  37. DEVELOPMENT OF FUNGIFORM PAPILLA AND TASTE BUDS
    Albert Farbman; Fiscal Year: 1992
    ..sensory nerves, the chorda tympani (CT), which innervates TBs exclusively, and the lingual, a branch of the trigeminal nerve, which provides somatosensory innervation to the papilla and the entire mucosa of the anterior part of the ..
  38. HERPES REACTIVATIONS AFTER CRANIAL NERVE SURGERY
    John Armstrong; Fiscal Year: 1980
    After microvascular decompression of the trigeminal nerve for relief of tic douloreux, about 70% of patients with a positive history of cold sores develop herpes lesions with onsets 2-5 days after surgery...
  39. Purinergic Receptors in Olfactory System
    Colleen Hegg; Fiscal Year: 2003
    ..This application will test the general hypothesis that noxious or trigeminal nerve stimulation of the peripheral olfactory system evokes the release of ATP that modulates responsiveness of ..
  40. MECHANISMS OF OROFACIAL NEUROPATHIC PAIN
    JOHN NEUBERT; Fiscal Year: 1999
    ..Orofacial neuropathic pain will be induced in an established guinea pig model of trigeminal nerve injury...
  41. ASSAY DEVELOPMENT FOR KAPPA2 OPIATE RECEPTORS
    Patricia Maguire; Fiscal Year: 1993
    ..It is found in many regions of the central nervous system, including the spinal tract of the trigeminal nerve, making it an important target area in orofacial pain management...
  42. Trigeminal Pain, Mechanisms and Control
    Jon Levine; Fiscal Year: 2005
    ..guidance of trigeminal sensory axons during development, addressing the genesis of the three divisions of the trigeminal nerve, discrete projects in the maxillary distribution, and divergence of projections for large- and small-diameter ..
  43. OPIOID PEPTIDE GENE EXPRESSION IN NUCLEUS CAUDALIS
    Michael Moskowitz; Fiscal Year: 1992
    ..in the neuronal expression of each of these genes that we have found after removal or stimulation of the trigeminal nerve in preliminary studies...
  44. CONFOCAL FLUORESCENCE IMAGING SYSTEM
    David Lagunoff; Fiscal Year: 1990
    ..quantitation of fluorescence and the capability for 3-D image reconstruction will enhance ongoing studies of trigeminal nerve injury, serotonergic axons in the area dentata, neurotensin localization in the CNS, structure of retinal ..
  45. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  46. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  47. Sensory Re-training following Orthognathic Surgery
    Ceib Phillips; Fiscal Year: 2005
    ..Our primary focus will be on the patient's perception of the negative impact of altered sensation on daily life. ..
  48. DRUG SENSITIVITY IN ELDERLY PSYCHIATRIC PATIENTS
    Ian Cook; Fiscal Year: 2002
    ..Cook will be well prepared to undertake independent and collaborative investigations, to expand his teaching roles, and to play a role in bridging basic science and clinical research within the Department. ..
  49. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 2003
    ..Our goal is to understand neuroinflammatory interactions in inflamed teeth in order to develop better treatments for dental pain. ..
  50. RESPONSE VARIABILITY IN TREATMENT RESISTANT DEPRESSION
    Ian Cook; Fiscal Year: 2006
    ..Secondary analyses will use general linear models and growth mixture modeling to examine how early cordance changes relate to patient and illness factors and to functional outcomes. [unreadable] [unreadable]..
  51. Ethanol, neurotrophins, and thalamocortical matching
    SANDRA MOONEY; Fiscal Year: 2006
    ..There are 33% fewer neurons in the principal sensory nucleus of the trigeminal nerve and somatosensory cortex (2nd and 4th order neurons) in ethanol-treated rats...
  52. Putative pheromones in the main olfactory system
    Weihong Lin; Fiscal Year: 2007
    ..abstract_text> ..
  53. Caspase Mechanisms after Brain Injury
    Michael Moskowitz; Fiscal Year: 2006
    ..Together these experiments will explore death receptor-mediated acute cell killing within brain in order to identify mechanisms and potential targets of ischemic and traumatic brain injury. ..
  54. Dine' Network For Environmental Health (DiNEH) Project
    Johnnye Lewis; Fiscal Year: 2007
    ..Its results will be generalizable throughout the Navajo Nation and to other land-based communities. ..
  55. Cytokine Regulation of Periradicular Pain in Humans
    Asma Khan; Fiscal Year: 2007
    ..Dr Kenneth Kornman of IL Genetics will serve as a consultant on this project and will oversee the genotyping and genetic analysis. Statistical consultation will be provided by Dr. Brad Pollock. ..
  56. INTERDEPARTMENTAL STROKE PROGRAM
    Michael Moskowitz; Fiscal Year: 2008
    ..abstract_text> ..
  57. Web-based Sleep Research Protocols and Standards
    Michael Chase; Fiscal Year: 2004
    ..It will also provide an infrastructure for the development of interactions and linkages between basic and clinical areas of investigation...
  58. Mechanisms of Nicotine Induced Neurogenic Inflammation
    Kenneth Hargreaves; Fiscal Year: 2005
    ....
  59. Nitric Oxide Control of CGRP in Trigeminal Neurons
    Paul Durham; Fiscal Year: 2002
    ..abstract_text> ..
  60. NEUROPATHIC PAIN FROM AN EXPERIMENTAL NEURITIS
    Gary Bennett; Fiscal Year: 2002
    ..Electrophysiological recordings from identified sensory axons will determine if abnormal discharge arises at the site of inflammation and if there is peripheral sensitization due to an antidromically-conducted ectopic discharge. ..
  61. GONADAL STEROID REGULATION OF THE BIOLOGICAL CLOCK
    Tamas Horvath; Fiscal Year: 2003
    ..abstract_text> ..
  62. Circle of Willis variability and migraine
    BRETT LEE CUCCHIARA; Fiscal Year: 2010
    ..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..