Genomes and Genes
Summary: The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the trigeminal ganglion and project to the trigeminal nucleus of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
Publications330 found, 100 shown here
- White matter brain and trigeminal nerve abnormalities in temporomandibular disorderMassieh Moayedi
Institute of Medical Science, University of Toronto, Toronto, ON, Canada
Pain 153:1467-77. 2012..cognitive function in TMD, but it is not known whether there are white matter (WM) abnormalities along the trigeminal nerve (CNV) or in the brain...
- Compartmental study of T(1) and T(2) in rat brain and trigeminal nerve in vivoMark D Does
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8042, USA
Magn Reson Med 47:274-83. 2002The integrated T(1)-T(2) characteristics of rat brain and trigeminal nerve water were studied in vivo using a rapid method for acquiring a series of images that depend on T(1) and T(2) relaxation times...
- Anatomical and electrophysiological analysis of the trigeminal nerve in a teleost fish, Oncorhynchus mykissLynne U Sneddon
Roslin Institute, Welfare Biology, Roslin, Midlothian, UK
Neurosci Lett 319:167-71. 2002The trigeminal nerve in the rainbow trout, Oncorhynchus mykiss, was examined for the presence of A-delta and C fibres...
- Use of a novel thermal operant behavioral assay for characterization of orofacial pain sensitivityJohn K Neubert
Department of Orthodontics, College of Dentistry, University of Florida, 1600 SW Archer Road, P O Box 100444, Gainesville, FL 32610 0444, USA
Pain 116:386-95. 2005..These data reflect an orofacial pain behavior profile that was based on an animal's responses in an operant escape paradigm. This technique allows evaluation of nociceptive processing and modulation throughout the neuraxis...
- Cerebral activation to intranasal chemosensory trigeminal stimulationJulie A Boyle
Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
Chem Senses 32:343-53. 2007..The overlapping pattern of cortical activation for trigeminal and olfactory stimuli is assumed to be due to the intimate connections in the processing of information from the 2 major intranasal chemosensory systems...
- Partial infraorbital nerve ligation as a model of trigeminal nerve injury in the mouse: behavioral, neural, and glial reactionsMei Xu
Department of Pharmacology, University of Washington, Seattle, Washington 98195 7280, USA
J Pain 9:1036-48. 2008b>Trigeminal nerve damage often leads to chronic pain syndromes including trigeminal neuralgia, a severely debilitating chronic orofacial pain syndrome...
- Differences and similarities between atypical facial pain and trigeminal neuropathic painHeli Forssell
Department of Oral Diseases, University Hospital, PL 52, FIN 20521 Turku, Finland
Neurology 69:1451-9. 2007....
- Delayed upregulation of ATP P2X3 receptors of trigeminal sensory neurons by calcitonin gene-related peptideElsa Fabbretti
Consiglio Nazionale delle Ricerche, Istituto Nazionale di Fisica della Materia Democritos National Simulation Center, International School for Advanced Studies, 34014 Trieste, Italy
J Neurosci 26:6163-71. 2006..This mechanism might contribute to pain sensitization and represents a model of neuronal plasticity in response to a migraine mediator...
- Magnetic field changes activate the trigeminal brainstem complex in a migratory birdDominik Heyers
Arbeitsgruppe Neurosensorik Animal Navigation, Institut für Biologie und Umweltwissenschaften, University of Oldenburg, D 26111 Oldenburg, Germany
Proc Natl Acad Sci U S A 107:9394-9. 2010..contains putative magnetosensory ferro-magnetic structures, is innervated by the ophthalmic branch of the trigeminal nerve (V1)...
- Comparison of P2X and TRPV1 receptors in ganglia or primary culture of trigeminal neurons and their modulation by NGF or serotoninManuela Simonetti
Neurobiology Sector, International School for Advanced Studies SISSA, Via Beirut 4, 34014 Trieste, Italy
Mol Pain 2:11. 2006..The characteristics of such receptors after short-term culture were compared with those of ganglia. Furthermore, their modulation by chronically-applied serotonin or NGF was investigated...
- Molecular mechanisms of sensitization of pain-transducing P2X3 receptors by the migraine mediators CGRP and NGFRashid Giniatullin
Neurobiology Sector and Italian Institute of Technology Unit, International School for Advanced Studies SISSA, 34014 Trieste, Italy
Mol Neurobiol 37:83-90. 2008..The different time domains of P2X3 receptor modulation by NGF and CGRP suggest that the therapeutic efficacy of novel antimigraine drugs depends on the time of administration...
- Impaired trigeminal nociceptive processing in patients with trigeminal neuralgiaM Obermann
Department of Neurology, University Duisburg Essen, Essen, Germany
Neurology 69:835-41. 2007..Between the attacks the patient is usually asymptomatic, but a constant dull background pain may persist in some cases. The mechanisms associated with the development of this chronic pain are not well understood...
- Orofacial deep and cutaneous tissue inflammation and trigeminal neuronal activation. Implications for persistent temporomandibular painH Imbe
Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School, Baltimore, MD, USA
Cells Tissues Organs 169:238-47. 2001..Since deep inputs may be more effective in inducing central neuronal excitation than cutaneous inputs, greater sensory disturbances may occur in pain conditions involving deep tissues than in those involving cutaneous tissues...
- Neuromodulation for depression: invasive and noninvasive (deep brain stimulation, transcranial magnetic stimulation, trigeminal nerve stimulation)Ian A Cook
UCLA Depression Research and Clinic Program, Semel Institute for Neuroscience and Human Behavior at UCLA, David Geffen School of Medicine at UCLA, Henry Samueli School of Engineering at UCLA, 760 Westwood Plaza, Los Angeles, CA 90095, USA Electronic address
Neurosurg Clin N Am 25:103-16. 2014..update readers on 3 particular interventions: deep brain stimulation, transcranial magnetic stimulation, and trigeminal nerve stimulation...
- Hoxa2- and rhombomere-dependent development of the mouse facial somatosensory mapFranck Oury
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, UMR 7104, BP 10142, Communaute Urbaine de Strasbourg, 67404 Illkirch Cedex, France
Science 313:1408-13. 2006..Moreover, early Hoxa2 expression in neuroepithelium prevents the trigeminal nerve from ectopically projecting to the cerebellum, whereas late expression in the principal sensory nucleus ..
- Conditioned response to a magnetic anomaly in the Pekin duck (Anas platyrhynchos domestica) involves the trigeminal nerveRafael Freire
School of Animal and Veterinary Sciences, Charles Sturt University, Locked Bag 588, Wagga Wagga, NSW 2650, Australia
J Exp Biol 215:2399-404. 2012..The trigeminal nerve was anaesthetised by injection of lignocaine hydrochloride 2-3 mm caudal to the medial canthus of each eye, ..
- Determinants for nasal trigeminal detection of volatile organic compoundsJ Enrique Cometto-Muniz
Chemosensory Perception Laboratory, Department of Surgery, University of California, San Diego, 9500 Gilman Drive, Mail Code 0957, La Jolla, CA 92093 0957, USA
Chem Senses 30:627-42. 2005....
- Magnetic field perception in the rainbow trout Oncorynchus mykiss: magnetite mediated, light dependent or both?Jens Hellinger
Lehrstuhl für Allgemeine Zoologie und Neurobiologie, Ruhr Universitat Bochum, Bochum, Germany
J Comp Physiol A Neuroethol Sens Neural Behav Physiol 198:593-605. 2012..Inactivation of the ophthalmic branch of the trigeminal nerve by local anaesthesia revealed its role in the perception of intensity/inclination of the magnetic field by ..
- Trigeminal nerve dysfunction after Gamma Knife surgery for trigeminal neuralgia: a detailed analysisShinji Matsuda
Gamma Knife House, Chiba Cardiovascular Center, Ichihara, Japan
J Neurosurg 113:184-90. 2010..The incidence of trigeminal nerve dysfunction, such as facial numbness or dysesthesia, has been reported to be higher than previously published,..
- The influence of training on chemosensory event-related potentials and interactions between the olfactory and trigeminal systemsAndrew Livermore
School of Social Sciences and Liberal Studies, Charles Sturt University, Bathurst, NSW 2790, Australia
Chem Senses 29:41-51. 2004..This was supported by a significant decrease of amplitudes of the event-related potentials at frontal recording sites following training with the test odor only..
- Molecular mechanism for local anesthetic action of eugenol in the rat trigeminal systemChul Kyu Park
National Research Laboratory for Pain, Dental Research Institute and Department of Physiology, School of Dentistry, Seoul National University, 28 2 Yeongeon Dong, Chongno Ku, Seoul 110 749, Republic of Korea
Pain 144:84-94. 2009..Taken together, these results suggest that eugenol may serve as local anesthetics for other pathological pain conditions in addition to its wide use in dental clinic...
- Visualization of vascular compression of the trigeminal nerve with high-resolution 3T MRI: a prospective study comparing preoperative imaging analysis to surgical findings in 40 consecutive patients who underwent microvascular decompression for trigeminalPaulo Roberto Lacerda Leal
Department of Neurosurgery, University Lyon 1, Lyon, France
Neurosurgery 69:15-25; discussion 26. 2011..High-resolution three-dimensional (3D) magnetic resonance imaging (MRI) has demonstrated its ability to predict fine trigeminal neurovascular anatomy...
- Trigeminal neuralgia associated with an anomalous artery originating from the persistent primitive trigeminal arteryYoshitaka Yamada
Department of Neurosurgery, Brain and Spine Surgery Center, Shiroyama Hospital, Osaka, Japan
Neurol Med Chir (Tokyo) 46:194-7. 2006..Microvascular decompression surgery disclosed the trigeminal nerve compressed by this AICA variant together with the superior cerebellar artery...
- Frequency of trigeminal nerve injuries following third molar removalRichard C Robert
Department of Oral and Maxillofacial Surgery, University of California, San Francisco 94143 0440, USA
J Oral Maxillofac Surg 63:732-5; discussion 736. 2005....
- Brainstem mechanisms underlying feeding behaviorsJ P Lund
Faculty of Dentistry Department of Physiology, McGill University, Montreal, Quebec, Canada
Curr Opin Neurobiol 8:718-24. 1998..Orofacial sensory feedback, antidromic firing in spindle afferents and intrinsic properties of motoneurons also contribute to the final masticatory motor output...
- Brainstem and trigeminal nerve changes after radiosurgery for trigeminal painAlessandra Gorgulho
Division of Neurosurgery, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095, USA
Surg Neurol 66:127-35; discussion 135. 2006..To evaluate the significance of radiological changes on follow-up MRIs after SRS for TN...
- Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the ratH Alimohammadi
Department of Biology, Wake Forest University, Winston Salem, NC 27109, USA
Chem Senses 25:61-6. 2000..to be scattered throughout the nasal epithelium, and arise from the nasopalatine and ethmoid branches of the trigeminal nerve. In the present study, the effects of nicotinic acetylcholine receptor (nAChR) blockers on ethmoid nerve ..
- High spatiotemporal resolution imaging of the neurovascular response to electrical stimulation of rat peripheral trigeminal nerve as revealed by in vivo temporal laser speckle contrastNan Li
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
J Neurosci Methods 176:230-6. 2009..Dural vessels enlarged by 40+/-8% and the blood velocity increased by 50+/-5%. The method described here could be very useful in understanding and studying disorders in the neurovascular system...
- TRPM5-expressing microvillous cells in the main olfactory epitheliumWeihong Lin
Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
BMC Neurosci 9:114. 2008..Here we examined the morphology and immunocytochemical properties of these microvillous-like cells using immunocytochemical methods...
- Olfactory/trigeminal interactions in nasal chemoreceptionGerard Brand
Laboratoire de Neurosciences, Universite de Franche Comte, Place Leclerc, 25000 Besancon, France
Neurosci Biobehav Rev 30:908-17. 2006..However, several structural, functional and methodological questions remain unsolved in the field of olfactory/trigeminal interactions and deserve further research...
- Trigeminocardiac reflex. A clinical phenomenon or a new physiological entity?B Schaller
Max Planck Institute for Neurological Research, Gleueler Strasse 50, 50931 Cologne, Germany
J Neurol 251:658-65. 2004..hypotension, apnea or gastric hypermotility during stimulation of any of the sensory branches of the trigeminal nerve. The sensory nerve endings of the trigeminal nerve send neuronal signals via the Gasserian ganglion to the ..
- Nasal chemosensory cells use bitter taste signaling to detect irritants and bacterial signalsMarco Tizzano
Rocky Mountain Taste and Smell Center, Department of Cell and Developmental Biology, University of Colorado Denver, Aurora, CO 80045, USA
Proc Natl Acad Sci U S A 107:3210-5. 2010..Detection of such irritants by the trigeminal nerve evokes protective reflexes, including sneezing, apnea, and local neurogenic inflammation of the mucosa...
- Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in ratsYoshiyuki Tsuboi
Department of Physiology, School of Dentistry, Nihon University, Kanda Surugadai, Chiyoda ku, Tokyo 101 8310, Japan Division of Functional Morphology, Dental Research Center, Nihon University School of Dentistry, Tokyo 101 8310, Japan
Pain 111:323-34. 2004....
- Outcome of trigeminal nerve section in the treatment of chronic cluster headacheR G Jarrar
Departments of Neurology, Mayo Clinic, Rochester, MN, USA
Neurology 60:1360-2. 2003..The authors followed 17 patients with intractable chronic cluster headache who underwent trigeminal nerve section...
- Pain in the trigeminal system: irritation of the nasal mucosa using short- and long-lasting stimuliThomas Hummel
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Germany
Int J Psychophysiol 47:147-58. 2003..g. induced by environmental agents...
- Randomized controlled trial of trigeminal nerve stimulation for drug-resistant epilepsyChristopher M DeGiorgio
Departments of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Neurology 80:786-91. 2013To explore the safety and efficacy of external trigeminal nerve stimulation (eTNS) in patients with drug-resistant epilepsy (DRE) using a double-blind randomized controlled trial design, and to test the suitability of treatment and ..
- Occipital nerve blockade in chronic cluster headache patients and functional connectivity between trigeminal and occipital nervesV Busch
Department of Neurology, University of Regensburg, Regensburg, Germany
Cephalalgia 27:1206-14. 2007....
- Trigeminal neuralgia due to multiple sclerosis: ultrastructural findings in trigeminal rhizotomy specimensS Love
Department of Neuropathology, Institute of Clinical Neurosciences, Frenchay Hospital, Bristol BS16 1LE, UK
Neuropathol Appl Neurobiol 27:238-44. 2001..The demyelination and associated juxtaposition of axons may therefore account for key aspects of the pathogenesis of trigeminal neuralgia...
- Trigeminal nerve stimulation: seminal animal and human studies for epilepsy and depressionChristopher M DeGiorgio
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Neurosurg Clin N Am 22:449-56, v. 2011..In humans thus far the technique has been applied noninvasively, and is termed external trigeminal nerve stimulation (eTNSTM).
- Neural coding of stimulus concentration in the human olfactory and intranasal trigeminal systemsM Bensafi
Universite Claude Bernard, Lyon, Laboratoire de Neurosciences Sensorielles, Comportement, Cognition, UMR 5020, Institut Federatif des Neurosciences de Lyon, IFR19, CNRS, Lyon, France
Neuroscience 154:832-8. 2008..Taken together, these results suggest separate but overlapping neural networks involved in encoding stimulus intensity in the two chemosensory systems...
- Nasal solitary chemoreceptor cell responses to bitter and trigeminal stimulants in vitroBrian D Gulbransen
Rocky Mountain Taste and Smell Center, University of Colorado Denver School of Medicine, Aurora, CO 80045, USA
J Neurophysiol 99:2929-37. 2008..alpha-gustducin, PLCbeta2, and TRPM5, leading to speculation that SCCs are the receptor cells that mediate trigeminal nerve responses to bitter taste receptor ligands...
- Progesterone produces antinociceptive and neuroprotective effects in rats with microinjected lysophosphatidic acid in the trigeminal nerve rootMin Ji Kim
Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, South Korea
Mol Pain 8:16. 2012In our present study, we studied the role of demyelination of the trigeminal nerve root in the development of prolonged nociceptive behavior in the trigeminal territory.
- Autogenous grafts/allografts/conduits for bridging peripheral trigeminal nerve gapsLarry M Wolford
Department of Oral and Maxillofacial Surgery, Texas A and M University Health Science Center, Baylor College of Dentistry, Dallas, TX, USA
Atlas Oral Maxillofac Surg Clin North Am 19:91-107. 2011..However, more research studies using these materials for TN repairs are essential to validate the superiority of these procedures...
- Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cellsMakoto Ohmoto
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Mol Cell Neurosci 38:505-17. 2008..Thus, the t1r3-WGA transgenic mice revealed the sweet/umami gustatory pathways from taste receptor cells and the trigeminal neural pathway from solitary chemoreceptor cells...
- An animal model for trigeminal neuralgia by compression of the trigeminal nerve rootDao Shu Luo
Department of Anatomy, Histology and Embryology, Basic Medical College, Fujian Medical University, Fuzhou, China
Pain Physician 15:187-96. 2012Microvascular compression of the trigeminal nerve root is a major cause of most trigeminal neuralgia (TN) in patients; however, no reliable animal model to further study the pathogenesis of TN currently exists.
- Reduction of pentylenetetrazole-induced seizure activity in awake rats by seizure-triggered trigeminal nerve stimulationE E Fanselow
Departments of Neurobiology and Biomedical Engineering, Duke University Medical Center, Durham, North Carolina 27710, USA
J Neurosci 20:8160-8. 2000..Here, we report that stimulation of another cranial nerve, the trigeminal nerve, can also cause cortical and thalamic desynchronization, resulting in a reduction of seizure activity in ..
- Brain activity during stimulation of the trigeminal nerve with noxious heatReny de Leeuw
Orofacial Pain Center, College of Dentistry, University of Kentucky, Lexington, KY 40536 0297, USA
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102:750-7. 2006The aim of this study was to observe areas of brain activation with painful hot stimulation to the trigeminal nerve.
- A rat model of radiofrequency ablation of trigeminal innervation via a ventral approach with stereotaxic surgeryEdward K Wong
Ophthalmology, University of California, Med Surge I, Room 118, Irvine 92697 4375, USA
Exp Eye Res 79:297-303. 2004..The purpose of this study was to create a rat model for neurotrophic keratopathy by denervating the trigeminal nerve through a ventral approach with stereotaxic surgery...
- Trigeminal nerve palsy in nasopharyngeal carcinoma: correlation between clinical findings and magnetic resonance imagingChunyan Cui
Imaging Diagnosis and Interventional Center, State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat Sen University, Guangzhou 510060, People s Republic of China
Head Neck 31:822-8. 2009Our aim was to document the relationship between clinical and MRI evidence of trigeminal nerve involvement.
- Oral irritant properties of menthol: sensitizing and desensitizing effects of repeated application and cross-desensitization to nicotineJ M Dessirier
Section of Neurobiology, Physiology and Behavior, University of California-Davis, One Shields Avenue, Davis, CA 95616, USA
Physiol Behav 73:25-36. 2001..Repeated application of menthol at the same short ISI was then resumed, and resulted in a significant mean increase in irritant intensity consistent with stimulus-induced recovery (SIR)...
- Iatrogenic injury to oral branches of the trigeminal nerve: records of 449 casesSøren Hillerup
Department of Oral and Maxillofacial Surgery, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
Clin Oral Investig 11:133-42. 2007The aims of this study were threefold: (1) to describe iatrogenic lesions to oral branches of the trigeminal nerve, signs and symptoms, and functional status, (2) to report on a simple neurosensory examination method, and (3) to discuss ..
- Compartmental study of diffusion and relaxation measured in vivo in normal and ischemic rat brain and trigeminal nerveM D Does
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8042, USA
Magn Reson Med 43:837-44. 2000The correlation between the apparent diffusion coefficient (ADC) and T(2) of water in rat brain and trigeminal nerve was investigated using a hybrid diffusion-weighted-CPMG imaging sequence...
- Clinical evaluation of targeting accuracy of gamma knife radiosurgery in trigeminal neuralgiaNicolas Massager
Gamma Knife Center and Department of Neurosurgery, University Hospital Erasme, Universite Libre de Bruxelles, Brussels, Belgium
Int J Radiat Oncol Biol Phys 69:1514-20. 2007..We also studied the applied radiation dose within the area of focal contrast enhancement on the trigeminal nerve root following radiosurgery.
- Species differences in the reflex effects of lingual afferent nerve stimulation on lip blood flow and arterial pressureS Koeda
Department of Maxillofacial Surgery, Tohoku University Graduate School of Dentistry, 980 8575 Sendai, Japan
J Comp Physiol B 173:629-36. 2003..Thus, species variability exists in the sympathetic-mediated systemic arterial blood pressure changes and parasympathetic-mediated lip blood flow responses themselves, and in the relationship between them...
- Trigeminal nerve stimulation in major depressive disorder: first proof of concept in an open pilot trialLara M Schrader
David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Epilepsy Behav 22:475-8. 2011Modulation of brain activity via trigeminal nerve stimulation is an emerging therapy in drug-resistant epilepsy...
- Focal enhancement of cranial nerve V after radiosurgery with the Leksell gamma knife: experience in 15 patients with medically refractory trigeminal neuralgiaR A Alberico
Departments of Diagnostic Radiology (R.A.A.) and Neurosurgery (R.A.F, Roswell Park Cancer Institute, Buffalo, NY
AJNR Am J Neuroradiol 22:1944-8. 2001..No correlation of enhancement with treatment response or time to follow-up existed (P >.05). CONCLUSION: The trigeminal nerve often enhances at the target site after radiosurgery...
- Persistence of attacks of cluster headache after trigeminal nerve root sectionManjit S Matharu
Headache Group, Institute of Neurology, University College London, UK
Brain 125:976-84. 2002..We report a patient with a trigeminal nerve section who continued to have attacks...
- Histologic analysis of a human trigeminal nerve after failed stereotactic radiosurgery: case reportAndrew B Foy
Department of Neurologic Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
Surg Neurol 68:655-8; discussion 658-9. 2007..However, little is known about the mechanism of pain relief after trigeminal neuralgia radiosurgery. We report the histologic findings of a human trigeminal nerve after failed radiosurgery for trigeminal neuralgia.
- Trigeminal nerve injuries after mandibular implant placement--practical knowledge for cliniciansFrederick Hegedus
Department of Oral and Maxillofacial Surgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
Int J Oral Maxillofac Implants 21:111-6. 2006Endosseous mandibular implant placement can result in injuries to the peripheral branches of the trigeminal nerve even with the most careful preoperative planning and intraoperative technique...
- Trigeminal activation using chemical, electrical, and mechanical stimuliE Iannilli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, Dresden, Germany
Pain 139:376-88. 2008..proprioceptive, and nociceptive information, including also chemosensory functions are expressed in the trigeminal nerve sensory response...
- The trigeminal nerve. Part IV: the mandibular divisionW E Shankland
Cranio 19:153-61. 2001The mandibular or third division of the trigeminal nerve is the largest of the three divisions. It is considered a mixed nerve. That is, like the ophthalmic and maxillary divisions, the mandibular conveys afferent fibers...
- Trigemino-cardiac reflex: the trigeminal depressor responses during skull base surgeryQingli Meng
Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan, Shandong, PR China
Clin Neurol Neurosurg 110:662-6. 2008..To observe and analyze the occurrence and management of the trigemino-cardiac reflex (TCR) defined as the phenomenon of abrupt drops in heart rate (HR) and blood pressure during skull base surgery...
- Trigeminal nerve stimulation for epilepsyChristopher M DeGiorgio
Department of Neurology, Geffen School of Medicine at UCLA, Los Angeles, USA
Neurology 61:421-2. 2003
- Trigeminal nerve injury associated with injection of local anesthetics: needle lesion or neurotoxicity?Søren Hillerup
Rigshospitalet and Dental School, University of Copenhagen, Denmark
J Am Dent Assoc 142:531-9. 2011..The authors used comprehensive national registry and clinical data to conduct a study of adverse drug reactions (ADRs), in particular neurosensory disturbance (NSD), associated with local anesthetics used in dentistry..
- Imaging the trigeminal nerveAlexandra Borges
Radiology Department, Instituto Portugues de Oncologia Francisco Gentil, Centro de Lisboa, Rua Prof Lima Basto, 1093, Lisboa, Portugal
Eur J Radiol 74:323-40. 2010Of all cranial nerves, the trigeminal nerve is the largest and the most widely distributed in the supra-hyoid neck. It provides sensory input from the face and motor innervation to the muscles of mastication...
- Trigeminal-parabrachial connections: possible pathway for nociception-induced cardiovascular reflex responsesG V Allen
Faculty of Medicine, Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
Brain Res 715:125-35. 1996..8 +/- 3.5 S.E.M.) subnuclei. The results demonstrate that nociceptive dental input received by the three subnuclei of the spinal trigeminal nucleus, particularly the subnucleus caudalis, is relayed to the lateral parabrachial nucleus...
- Pilot study of trigeminal nerve stimulation (TNS) for epilepsy: a proof-of-concept trialChristopher M DeGiorgio
UCLA Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Epilepsia 47:1213-5. 2006The safety and preliminary efficacy of trigeminal nerve stimulation (TNS) for epilepsy was evaluated in a pilot feasibility study of transcutaneous stimulation of the infraorbital and supraorbital branches of the trigeminal nerve...
- Acute and long-term safety of external trigeminal nerve stimulation for drug-resistant epilepsyJuliana Pop
Department of Neurology, Olive View Internal Medicine Program, UCLA School of Medicine, Los Angeles, CA 90095, USA
Epilepsy Behav 22:574-6. 2011b>Trigeminal nerve stimulation (TNS) is a novel therapy for drug-resistant epilepsy...
- Utility of magnetic resonance cisternography using three-dimensional fast asymmetric spin-echo sequences with multiplanar reconstruction: the evaluation of sites of neurovascular compression of the trigeminal nerveTatsurou Tanaka
Department of Dental Radiology, Kyushu Dental College, Kitakyushu, Japan
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:215-25. 2005....
- Responses to olfactory and intranasal trigeminal stimuli: relation to the respiratory cycleA Haehner
Department of Otorhinolaryngology, University of Dresden Medical School, 01307 Dresden, Fetscherstr 74, Germany
Neuroscience 175:178-83. 2011..These data indicate on an electrophysiological level that there is priming of both olfactory and trigeminally mediated sensations in relation to the respiratory cycle...
- Trigeminal nerve-mediated reflex arterial blood pressure decrease and vasodilatation in lower lip of the rabbitMakoto Yasuda
Dento oral Anesthesiology, Tohoku University Graduate School of Dentistry, 980 8575 Sendai, Japan
Brain Res 987:59-66. 2003..In contrast, the evoked decrease in contralateral LBF was proportional to the decrease in arterial blood pressure, suggesting that the former was secondary to the latter...
- Application of a pro-inflammatory agent to the orbital portion of the rat infraorbital nerve induces changes indicative of ongoing trigeminal painRafael Benoliel
The Department of Oral Diagnosis, Hadassah School of Dental Medicine, The Hebrew University, Jerusalem, Israel
Pain 99:567-78. 2002..This model of inflammation-induced neuropathic pain is highly applicable to the study of neuroinflammatory orofacial pain...
- BOLD responses to trigeminal nerve stimulationNathalie Just
Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
Magn Reson Imaging 28:1143-51. 2010..investigates a new model of barrel cortex activation using stimulation of the infraorbital branch of the trigeminal nerve. A robust and reproducible activation of the rat barrel cortex was obtained following trigeminal nerve ..
- Clinical characteristics of trigeminal nerve injury referrals to a university centreA B G Tay
Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina at Chapel Hill, CB 7450, Chapel Hill, NC 27599 7450, USA
Int J Oral Maxillofac Surg 36:922-7. 2007The aim of this retrospective study was to determine the aetiology and characteristics of trigeminal nerve injuries referred to a university centre with nerve injury care...
- Radiosurgery for trigeminal neuralgia: is sensory disturbance required for pain relief?Bruce E Pollock
Department of Neurological Surgery, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Neurosurg 105:103-6. 2006..Over the past 15 years stereotactic radiosurgery has become an accepted surgical option for patients with medically unresponsive trigeminal neuralgia (TN). The mechanism whereby radiosurgery causes pain relief remains unclear...
- Intranasal chemosensory function of the trigeminal nerve and aspects of its relation to olfactionThomas Hummel
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, 01307 Dresden, Germany
Int Arch Occup Environ Health 75:305-13. 2002..The review outlines characteristics of the intranasal trigeminal chemosensory system. In addition, it provides selective comparisons of the trigeminal and olfactory systems, the two of which interact at multiple levels...
- Heterotopic ischemic pain attenuates somatosensory evoked potentials induced by electrical tooth stimulation: diffuse noxious inhibitory controls in the trigeminal nerve territoryKeiko Fujii
Anesthesiology and Clinical Physiology, Department of Oral Restitution, Division of Oral Health Sciences, Graduate School, Tokyo Medical and Dental University, Yushima, Bunkyo ku, Japan
Eur J Pain 10:495-504. 2006..electrical tooth stimulation, triggering diffuse noxious inhibitory controls (DNIC) and after-effects in the trigeminal nerve territory...
- Inflammatory pseudotumor of the trigeminal nerve: a neoplastic mimic you do not want to missJ G Seol
Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
AJNR Am J Neuroradiol 30:1941-3. 2009..We present a case of pseudotumor originating from the trigeminal nerve in a patient who presented with headache and facial numbness...
- Subjects with congenital anosmia have larger peripheral but similar central trigeminal responsesJ Frasnelli
Smell and Taste Clinic, Department of Otorhinolaryngology, University of Dresden Medical School, Dresden, Germany
Cereb Cortex 17:370-7. 2007Most odorants not only stimulate olfactory receptor neurons but also activate the intranasal trigeminal nerve. The simultaneous activation of the olfactory and the trigeminal system leads to an interaction in the brain...
- Chemosensory event-related potentials change with ageT Hummel
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
Electroencephalogr Clin Neurophysiol 108:208-17. 1998..The age-related decrease of CSERP amplitudes appeared to follow a different time course for responses to trigeminal and olfactory stimulants...
- A new animal model of trigeminal neuralgia produced by administration of cobra venom to the infraorbital nerve in the ratJian Xiong An
Department of Anesthesiology, Central South University Xiangya Hospital, Changsha, China
Anesth Analg 113:652-6. 2011..We have developed an experimental animal model for trigeminal neuralgia using a technique of injecting cobra venom into the infraorbital nerve (ION) trunk...
- Effectiveness of cervical sympathetic ganglia block on regeneration of the trigeminal nerve following transection in ratsNaotoshi Hanamatsu
Department of Anesthesiology, School of Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan
Reg Anesth Pain Med 27:268-76. 2002Stellate ganglion block (SGB) is one treatment option for human trigeminal nerve injury...
- TRPV1 receptors and nasal trigeminal chemesthesisWayne L Silver
Department of Biology, Wake Forest University, Winston Salem, NC 27106, USA
Chem Senses 31:807-12. 2006The trigeminal nerve responds to a wide variety of irritants...
- Solitary chemoreceptor cell survival is independent of intact trigeminal innervationBrian Gulbransen
Department of Cell and Developmental Biology, Neuroscience Program and Rocky Mountain Taste and Smell Center, School of Medicine University of Colorado Denver, Aurora, Colorado 80045, USA
J Comp Neurol 508:62-71. 2008..2003] Proc Natl Acad Sci USA 100:8981-8986). SCCs are innervated by peptidergic trigeminal nerve fibers (Finger et al...
- SUNCT: bilateral hypothalamic activation during headache attacks and resolving of symptoms after trigeminal decompressionTill Sprenger
Department of Neurology, Technische Universitat Munchen, Klinikum rechts der Isar, Moehlstr 28, D 81675 Munich, Germany
Pain 113:422-6. 2005..Interestingly, this patient became completely pain free after surgical decompression of the ipsilateral trigeminal nerve. We hypothesize that in this case with a central predisposition for trigeminal autonomic cephalgias, a ..
- Management of patients with trigeminal nerve injuries after mandibular implant placementRichard A Kraut
Oral and Maxillofacial Surgery, Montefiore Medical Center, Department of Dentistry, Bronx, NY 10467, USA
J Am Dent Assoc 133:1351-4. 2002..All dentists who place mandibular implants should be aware of the appropriate early management of these injuries, as well as the appropriate time to refer patients with these injuries to a microneurosurgeon...
- Cavernous malformation of the trigeminal nerve manifesting with trigeminal neuralgia: case reportVivek R Deshmukh
Division of Neurological Surgery, Barrow Neurological Institute, St Joseph s Hospital and Medical Center, Phoenix, Arizona 85013, USA
Neurosurgery 56:E623; discussion E623. 2005We describe a patient with a cavernous malformation within the trigeminal nerve at the nerve root entry zone who presented with trigeminal neuralgia.
- Microvascular decompression of the trigeminal nerve in the treatment of SUNCT and SUNAMax Williams
Department of Neurology, Gold Coast Hospital, Southport, Australia
J Neurol Neurosurg Psychiatry 81:992-6. 2010....
- Calcitonin gene-related peptide and nitric oxide in the trigeminal ganglion: cerebral vasodilatation from trigeminal nerve stimulation involves mainly calcitonin gene-related peptideL Edvinsson
Department of Internal Medicine, Lund University Hospital, Sweden
J Auton Nerv Syst 70:15-22. 1998..These data suggest that although NOS is seen in several trigeminal ganglion cells and coexists with CGRP in a subpopulation of the sensory neurons, its role in trigeminally mediated vasodilatation was not significant...
- Event-related fMRI with painful electrical stimulation of the trigeminal nerveSabine Fitzek
Department of Neurology, Friedrich Schiller University Jena, Jena, Germany
Magn Reson Imaging 22:205-9. 2004..The aim of the present study was to develop and implement painful stimulation of the trigeminal nerve, which can be applied with event-related paradigms by using MRI...
- Peripheral mechanisms for the initiation of pain following trigeminal nerve injuryPeter P Robinson
Department of Oral and Maxillofacial Surgery, School of Clinical Dentistry, University of Sheffield, Claremont Crescent, Sheffield S10 2TA United Kingdom
J Orofac Pain 18:287-92. 2004Injury to a branch of the trigeminal nerve may lead to the development of chronic pain in the affected area...
- Activation of glia and microglial p38 MAPK in medullary dorsal horn contributes to tactile hypersensitivity following trigeminal sensory nerve injuryZheng Gen Piao
Department of Physiology, College of Dentistry and Dental Research Institute, Seoul National University, Seoul 110 749, Republic of Korea
Pain 121:219-31. 2006..These results suggest that glial activation in MDH plays an important role in the development of neuropathic pain and activation of p38 MAPK in hyperactive microglia contributes to pain hypersensitivity in IAMNT model...
- Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot studyDelphine Magis
Headache Research Unit, Department of Neurology, Liege University, CHR Citadelle, Liege, Belgium
Lancet Neurol 6:314-21. 2007..Occipital nerve stimulation (ONS) is a new, safe strategy for intractable headaches. We undertook a prospective pilot trial of ONS in drCCH to assess clinical efficacy and pain perception...
- Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine modelHayrunnisa Bolay
Stroke and Neurovascular Regulation Laboratory, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 8:136-42. 2002Although the trigeminal nerve innervates the meninges and participates in the genesis of migraine headaches, triggering mechanisms remain controversial and poorly understood...
- Interactions between olfaction and the trigeminal system: what can be learned from olfactory lossJohannes Frasnelli
Cognitive Neuroscience Unit, Montreal Neurological Institute, Montreal, Quebec, Canada
Cereb Cortex 17:2268-75. 2007The olfactory and the trigeminal systems have a close relationship. Most odorants also stimulate the trigeminal nerve. Further, subjects with no sense of smell exhibit a decreased trigeminal sensitivity with unclear underlying mechanisms...
- The trigemino-cervical reflex in normal subjectsI Milanov
St Naum University Neurological Hospital, Sofia, Bulgaria
Funct Neurol 16:129-34. 2001..In conclusion, the trigemino-cervical reflex may be most easily obtained from the relaxed sternocleidomastoid muscle after supraorbital nerve stimulation...
- The fine branches of the human trigeminal nerveM Yu Uryvaev
Department of Human Anatomy, Moscow State Medical Stomatological University, Russia
Neurosci Behav Physiol 38:157-60. 2008..The results showed that numerous branches of diameter 50-150 microm ran directly from the trigeminal nerve, more from the outer and less from the deeper surface, innervating the walls of the trigeminal cavity...
- Intracisternal administration of NR2 subunit antagonists attenuates the nociceptive behavior and p-p38 MAPK expression produced by compression of the trigeminal nerve rootHye J Jeon
Department of Oral Physiology, School of Dentistry, Kyungpook National University, Daegu, Korea
Mol Pain 7:46. 2011..in the modulation of nociceptive behavior and p-p38 MAPK expression in a rat model with compression of the trigeminal nerve root...
- Therapeutic implications of central and peripheral neurologic mechanisms in migraineChristian Waeber
Neuroscience Center, Department of Radiology, Massachusetts General Hospital Harvard Medical School, Charlestown, MA 02129, USA
Neurology 61:S9-20. 2003
- Central demyelination of the Vth nerve root in trigeminal neuralgia associated with vascular compressionS Love
Department of Neuropathology, Frenchay Hospital, Bristol, UK
Brain Pathol 8:1-11; discussion 11-2. 1998..The partly aberrant nature of the myelination within the region of vascular compression may contribute to the persistence of symptoms in some patients after decompressive surgery...
- Ultrastructural analysis of a putative magnetoreceptor in the beak of homing pigeonsGerta Fleissner
Zoologisches Institut, J W Goethe Universität Frankfurt am Main, Siesmayerstrasse 70, D 60054 Frankfurt am Main, Germany
J Comp Neurol 458:350-60. 2003....
- Intranasal CNS delivery of drugs against organophosphorous threat agentsARYAN MANGALAM NAMBOODIRI; Fiscal Year: 2013..involves possible transport through the neuroepithelial cells of olfactory epithelium as well as through trigeminal nerve pathways...
- Nicotine Modulation of Parasympathetic Cardiac NeuronsDavid Mendelowitz; Fiscal Year: 2013..Electrical or mechanical stimulation of the trigeminal nerve evokes a dramatic decrease in heart rate in animals including man, and has often been termed the `..
- Satellite Glial CellsLuc Jasmin; Fiscal Year: 2013..the contribution of SGC-specific genes to the control of neuronal excitability and sensory behavior following trigeminal nerve injury...
- Defining Target Contribution to Orofacial Pain by Antisense OligonucleotidesZhigang Luo; Fiscal Year: 2009..in vitro biochemical studies and non-orofacial, nerve injury-induced chronic pain models, we hypothesize that trigeminal nerve injury leads to altered expression of the calcium channel alpha-2-delta-1 subunit (Cava2d1) and ..
- Trigeminal Nerve Stimulation for EpilepsyChristopher DeGiorgio; Fiscal Year: 2012..to the ultimate FDA approval and commercialization of a new minimally invasive treatment for epilepsy, Trigeminal Nerve Stimulation...
- NEURONAL PATHWAYS UNDERLYING IN VITRO MOTOR LEARNINGJoyce Keifer; Fiscal Year: 2013..stimuli as in behaving animals we use paired stimulation of the auditory nerve (the "tone" CS) with the trigeminal nerve (the "airpuff" US) that results in burst discharge in the abducens nerve, which controls blinking in this ..
- Development of a Mouse Trigeminal Pain ModelANDREW RUSSO; Fiscal Year: 2009..We will use intranasal administration to target the trigeminal nerve, which innervates the nasal mucosa...
- Netrin5 in Mammalian NeurodevelopmentRobert W Burgess; Fiscal Year: 2013..points and dorsal root entry zones in the mouse embryonic spinal cord, and is associated with the sensory trigeminal nerve and possibly other cranial nerves...
- Aberrant Blink Reflex Motor Learning in a Rat Model of Parkinsons DiseaseJAIME A KAMINER; Fiscal Year: 2013..inducing protocols involving the presentation of high frequency stimulation to the supraorbital branch of the trigeminal nerve. These data will demonstrate the degree of disruption for short-term plasticity and long term learning of ..
- Nasal solitary chemosensory cells linking irritation to inflammationMarco Tizzano; Fiscal Year: 2013..solitary chemosensory cells (SCCs) which are specialized chemo-sensitive epithelial cells innervated by the trigeminal nerve. SCCs express elements of the bitter taste transduction cascade, i.e...
- International collaborative research to develop quantitive sensory testing guidelMark Drangsholt; Fiscal Year: 2009..Quantitative sensory testing (QST) of the trigeminal nerve has helped elucidate the mechanisms of a subset of these pain conditions...
- Civamide Nasal Spray for the Treatment of Postherpetic Neuralgia of the TrigeminaScott B Phillips; Fiscal Year: 2013..of concept clinical study of Civamide Nasal Spray for the treatment of postherpetic neuralgia (PHN) of the trigeminal nerve [(TN), a severely disabling facial pain syndrome]...
- Gene Therapy for Nerve InjuryLuc Jasmin; Fiscal Year: 2010..Oral, facial, and head pain from trigeminal nerve dysfunction is a common clinical problem and one of the most challenging to treat...
- A novel pathway mediating the development of chronic orofacial neuropathic painOswald Steward; Fiscal Year: 2013..Based on our preliminary data from a trigeminal nerve injury model and in non-orofacial pain models, we hypothesize that trigeminal nerve injury induced ..
- Nasal Solitary Chemoreceptor Cells: Detection of Pathogenic BacteriaSue Kinnamon; Fiscal Year: 2013..of specialized chemoreceptor cells (solitary chemosensory cells) that form functional contacts with the trigeminal nerve. Activation of the trigeminal nerve either directly by irritants or through the agency of these cells evokes ..
- IONTOPHORESIS OF ANTIVIRALS TO HERPES EYE INFECTIONSJames Hill; Fiscal Year: 1980..from the homogenates of the trigeminal ganglia, superior cervical ganglia, the ophthalmic branch of the trigeminal nerve, and the root-entry zone of the trigeminal nerve...
- TRIGEMINOHYPOTHALAMIC TRACTRami Burstein; Fiscal Year: 1999..painful stimuli of the face suggests that sensory information that originates in structures Innervated by the trigeminal nerve is available to these neurons...
- Development of an Implantable Trigeminal Nerve Stimulation System for Drug ResistChristopher DeGiorgio; Fiscal Year: 2013..b>Trigeminal Nerve Stimulation (TNS) is an emerging neuromodulation therapy for DRE, which has unique advantages over other ..
- Primary Afferent Transmission in the Trigeminal Dorsal HornTALLY MARIE MILNES; Fiscal Year: 2013..to investigate the cellular mechanisms underlying synaptic transmission between the central terminals of the trigeminal nerve (trigeminal afferents) and neurons located in the spinal trigeminal nucleus caudalis (Vc), a brainstem region ..
- TRIGGERING MECHANISMS FOR MIGRANINE HEADACHEMOSKOWITZ MICHAEL; Fiscal Year: 2006..Although the headache phase involves cerebral and extracerebral blood vessels and perivascular trigeminal nerve fibers, the triggering mechanisms of migraine are not known...
- Novel Operant Thermal Assessments of Orofacial PainJOHN NEUBERT; Fiscal Year: 2007..be investigated: Aim #1, to evaluate an operant model of thermal hyperalgesia and allodynia for evaluating trigeminal nerve mediated pain; and Aim #2, to investigate the effects of opioid and non-opioid mediated analgesia on thermal ..
- MOLECULAR GENETICS OF SENSORY GANGLIA DEVELOPMENTAlexander Schier; Fiscal Year: 2007..Injuries and malformations of the trigeminal nerve are clinically and cosmetically devastating and are often associated with trigeminal neuralgia, a severe and ..
- Recombinant Herpes Injection into Trigeminal GangliaDavid Yeomans; Fiscal Year: 2004..In so doing, we hope to provide initial support for what may be a new long-lasting treatment for trigeminal nerve-related pain.
- Roles of neurotrophic factors in dental pulp innervationChristopher Nosrat; Fiscal Year: 2003..It is anatomically well-defined and becomes richly innervated by trigeminal nerve fibers...
- VASCULAR RESPONSES DURING CORTICAL SPREADING DEPRESSIONDavid Busija; Fiscal Year: 2001..arterioles via mechanisms intrinsic to the vessel wall--activation of perivascular fibers associated with the trigeminal nerve, or by an endothelium-dependent pial arteriolar dilation arising secondary to dilation of intracortical ..
- Chronic Compression of the Trigeminal GangliaDavid Yeomans; Fiscal Year: 2009..In the majority of cases, the pain can be traced to chronic compression of the trigeminal nerve roots by a blood vessel, leading to demyelination of the compressed roots...
- AGE-RELATED CHANGE IN TRIGEMINAL GANGLION EXCITABILITYThomas Baumann; Fiscal Year: 2003..While vascular compression of the trigeminal nerve root appears to be the main element in the etiology of trigeminal neuralgia, an age-related change in the ..
- BEHAVIORAL CORRELATES OF NEURAL PLASTICITYV Ramachandran; Fiscal Year: 2001..We will also perform 3 additional experiments. First, we will examine patients after section of the trigeminal nerve (ganglion) to find out if they refer sensations from the hand to the face...
- NERVE-MUSCLE INTERACTIONS DURING JAW MUSCLE DEVELOPMENTCHARLES WIDMER; Fiscal Year: 2002..of masticatory muscle fibers and the muscle fiber distribution within each jaw muscle are dependent on trigeminal nerve-muscle interactions...
- OROFACIAL PAIN RESEARCH CENTERGlenn Clark; Fiscal Year: 1990..One of these projects involve an animal model. This project is on herpes simplex virus and its effect on trigeminal nerve function in guinea pigs...
- UTILIZATION OF TRIGEMINAL EVOKED POTENTIALS IN DENTISTRYCHARLES WIDMER; Fiscal Year: 1990..electrophysiological techniques to investigate and evaluate the peripheral and central pathways of the trigeminal nerve and to apply these techniques to dental disorders such as trigeminal nerve injury...
- EFFECT OF UNTRAOCULAR GRAFTING ON THE CORNEALawrence Borges; Fiscal Year: 1992..In a pilot study we have examined two animal models of neuroparalytic keratitis: One as a result of trigeminal nerve transection and the other as a consequence of systemic administration of capsaicin (a drug known to destroy ..
- MOLECULAR BASIS OF ACTION OF NOVEL SENSORY IRRITANTSIgor Mezine; Fiscal Year: 1999..using the digital fluorescent determination of intracellular calcium in trigeminal sensory neurons in vitro, trigeminal nerve recordings in vivo and in artificial lipid bilayers...
- DENTAL SENSORY MECHANISMSThomas Baumann; Fiscal Year: 1999..The hydrodynamic theory implies the presence of mechanosensitive transducer elements in trigeminal nerve endings. We hypothesize that the transducer elements are mechanosensitive ion channels...
- EARLY CHANGES IN POTENTIAL BRAIN TUMOR TISSUESHIRLEY SOUKUP; Fiscal Year: 1980..Our main objective is to study early stages of oncogenesis in neural target tissues. Brain and trigeminal nerve ganglia are removed from rats treated transplacentally with ENU...
- NERVE GROWTH FACTOR AND OROFACIAL NEUROPATHIC PAINLeigh Anderson; Fiscal Year: 2001..Finally, clinical studies suggest that lesions of the trigeminal nerve lead to chronic pain conditions that differ from those of segmental nerves (e.g...
- DEVELOPMENT OF FUNGIFORM PAPILLA AND TASTE BUDSAlbert Farbman; Fiscal Year: 1992..sensory nerves, the chorda tympani (CT), which innervates TBs exclusively, and the lingual, a branch of the trigeminal nerve, which provides somatosensory innervation to the papilla and the entire mucosa of the anterior part of the ..
- HERPES REACTIVATIONS AFTER CRANIAL NERVE SURGERYJohn Armstrong; Fiscal Year: 1980After microvascular decompression of the trigeminal nerve for relief of tic douloreux, about 70% of patients with a positive history of cold sores develop herpes lesions with onsets 2-5 days after surgery...
- Purinergic Receptors in Olfactory SystemColleen Hegg; Fiscal Year: 2003..This application will test the general hypothesis that noxious or trigeminal nerve stimulation of the peripheral olfactory system evokes the release of ATP that modulates responsiveness of ..
- MECHANISMS OF OROFACIAL NEUROPATHIC PAINJOHN NEUBERT; Fiscal Year: 1999..Orofacial neuropathic pain will be induced in an established guinea pig model of trigeminal nerve injury...
- ASSAY DEVELOPMENT FOR KAPPA2 OPIATE RECEPTORSPatricia Maguire; Fiscal Year: 1993..It is found in many regions of the central nervous system, including the spinal tract of the trigeminal nerve, making it an important target area in orofacial pain management...
- Trigeminal Pain, Mechanisms and ControlJon Levine; Fiscal Year: 2005..guidance of trigeminal sensory axons during development, addressing the genesis of the three divisions of the trigeminal nerve, discrete projects in the maxillary distribution, and divergence of projections for large- and small-diameter ..
- OPIOID PEPTIDE GENE EXPRESSION IN NUCLEUS CAUDALISMichael Moskowitz; Fiscal Year: 1992..in the neuronal expression of each of these genes that we have found after removal or stimulation of the trigeminal nerve in preliminary studies...
- CONFOCAL FLUORESCENCE IMAGING SYSTEMDavid Lagunoff; Fiscal Year: 1990..quantitation of fluorescence and the capability for 3-D image reconstruction will enhance ongoing studies of trigeminal nerve injury, serotonergic axons in the area dentata, neurotensin localization in the CNS, structure of retinal ..
- Molecular Boundaries For Trigeminal Chemosensory ImpactJ Cometto Muniz; Fiscal Year: 2006..abstract_text> ..
- CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTIONJ Enrique Cometto Muniz; Fiscal Year: 2010..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
- Sensory Re-training following Orthognathic SurgeryCeib Phillips; Fiscal Year: 2005..Our primary focus will be on the patient's perception of the negative impact of altered sensation on daily life. ..
- DRUG SENSITIVITY IN ELDERLY PSYCHIATRIC PATIENTSIan Cook; Fiscal Year: 2002..Cook will be well prepared to undertake independent and collaborative investigations, to expand his teaching roles, and to play a role in bridging basic science and clinical research within the Department. ..
- DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATIONMARGARET BYERS; Fiscal Year: 2003..Our goal is to understand neuroinflammatory interactions in inflamed teeth in order to develop better treatments for dental pain. ..
- RESPONSE VARIABILITY IN TREATMENT RESISTANT DEPRESSIONIan Cook; Fiscal Year: 2006..Secondary analyses will use general linear models and growth mixture modeling to examine how early cordance changes relate to patient and illness factors and to functional outcomes. [unreadable] [unreadable]..
- Ethanol, neurotrophins, and thalamocortical matchingSANDRA MOONEY; Fiscal Year: 2006..There are 33% fewer neurons in the principal sensory nucleus of the trigeminal nerve and somatosensory cortex (2nd and 4th order neurons) in ethanol-treated rats...
- Putative pheromones in the main olfactory systemWeihong Lin; Fiscal Year: 2007..abstract_text> ..
- Caspase Mechanisms after Brain InjuryMichael Moskowitz; Fiscal Year: 2006..Together these experiments will explore death receptor-mediated acute cell killing within brain in order to identify mechanisms and potential targets of ischemic and traumatic brain injury. ..
- Dine' Network For Environmental Health (DiNEH) ProjectJohnnye Lewis; Fiscal Year: 2007..Its results will be generalizable throughout the Navajo Nation and to other land-based communities. ..
- Cytokine Regulation of Periradicular Pain in HumansAsma Khan; Fiscal Year: 2007..Dr Kenneth Kornman of IL Genetics will serve as a consultant on this project and will oversee the genotyping and genetic analysis. Statistical consultation will be provided by Dr. Brad Pollock. ..
- INTERDEPARTMENTAL STROKE PROGRAMMichael Moskowitz; Fiscal Year: 2008..abstract_text> ..
- Web-based Sleep Research Protocols and StandardsMichael Chase; Fiscal Year: 2004..It will also provide an infrastructure for the development of interactions and linkages between basic and clinical areas of investigation...
- Mechanisms of Nicotine Induced Neurogenic InflammationKenneth Hargreaves; Fiscal Year: 2005....
- Nitric Oxide Control of CGRP in Trigeminal NeuronsPaul Durham; Fiscal Year: 2002..abstract_text> ..
- NEUROPATHIC PAIN FROM AN EXPERIMENTAL NEURITISGary Bennett; Fiscal Year: 2002..Electrophysiological recordings from identified sensory axons will determine if abnormal discharge arises at the site of inflammation and if there is peripheral sensitization due to an antidromically-conducted ectopic discharge. ..
- GONADAL STEROID REGULATION OF THE BIOLOGICAL CLOCKTamas Horvath; Fiscal Year: 2003..abstract_text> ..
- Circle of Willis variability and migraineBRETT LEE CUCCHIARA; Fiscal Year: 2010..If this hypothesis is confirmed, this could lead to new treatments based on a better understanding of migraine mechanisms and might help identify patients with migraine who are at risk of stroke. ..