Genomes and Genes
Summary: The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB.
Publications210 found, 100 shown here
- Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cordR Deumens
Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, 6200 MD, Maastricht, The Netherlands
Exp Neurol 200:89-103. 2006Cellular transplantation, including olfactory ensheathing cells (OEC) and olfactory nerve fibroblasts (ONF), after experimental spinal cord injury in the rat has previously resulted in regrowth of severed corticospinal (CS) axons across ..
- Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminalsM Ennis
Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Neurophysiol 86:2986-97. 2001Olfactory receptor neurons of the nasal epithelium project via the olfactory nerve (ON) to the glomeruli of the main olfactory bulb, where they form glutamatergic synapses with the apical dendrites of mitral and tufted cells, the output ..
- Intranasal delivery of insulin via the olfactory nerve pathwayDan B Renner
Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, St Paul, MN 55101, USA
J Pharm Pharmacol 64:1709-14. 2012..an investigation into the pathways by which intranasal administration delivers insulin to the CNS, this study has focused on the direct delivery of insulin from the olfactory mucosa to the olfactory bulbs via the olfactory nerve pathway.
- Neural regeneration and the peripheral olfactory systemJames E Schwob
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
Anat Rec 269:33-49. 2002..e., the olfactory epithelium reconstitutes, the olfactory nerve regenerates, and the olfactory bulb is reinnervated, with a facility that is unique within the mammalian ..
- Composition of the migratory mass during development of the olfactory nerveAlexandra M Miller
Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Comp Neurol 518:4825-41. 2010The embryonic development of the olfactory nerve includes the differentiation of cells within the olfactory placode, migration of cells into the mesenchyme from the placode, and extension of axons by the olfactory sensory neurons (OSNs)...
- Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathwayAlbrecht F Kiderlen
Department of Infectious Diseases, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
Parasitol Res 94:49-52. 2004..A similar invasion pathway has been described for N. fowleri. The data suggest that the olfactory nerve pathway is a likely route for natural infection of the brain by B. mandrillaris amebae.
- A balance of BMP and notch activity regulates neurogenesis and olfactory nerve formationEsther Maier
Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
PLoS ONE 6:e17379. 2011..system has been thoroughly studied, the molecular mechanisms regulating the initial formation of the olfactory nerve, the first cranial nerve, remain poorly defined...
- Olfactory ensheathing cells: the primary innate immunocytes in the olfactory pathway to engulf apoptotic olfactory nerve debrisZhida Su
Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Ministry of Education, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, China
Glia 61:490-503. 2013..of the apoptotic ORNs corpses is a fundamental process serving important functions in the regulation of olfactory nerve turnover and regeneration. However, little is known about the underlying mechanisms...
- Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminalsZ Shao
Program in Neuroscience, University of Maryland School of Medicine, Baltimore, 21201 MD, USA
J Neurophysiol 101:1988-2001. 2009b>Olfactory nerve axons terminate in olfactory bulb glomeruli forming excitatory synapses onto the dendrites of mitral/tufted (M/T) and juxtaglomerular cells, including external tufted (ET) and periglomerular (PG) cells...
- Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibresYing Li
Spinal Repair Unit, Institute of Neurology, University College London, London, United Kingdom
Glia 52:245-51. 2005..their outer surface, the olfactory ensheathing cell channels have a basal lamina and an outer encirclement of olfactory nerve fibroblasts...
- An updated review of clinical olfactionEric H Holbrook
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
Curr Opin Otolaryngol Head Neck Surg 14:23-8. 2006..Disorders of the sense of smell can result through hundreds of different processes, but most commonly occur from upper-respiratory-tract infections, trauma, and chronic rhinosinusitis...
- External tufted cells drive the output of olfactory bulb glomeruliDidier De Saint Jan
Institut National de la Santé et de la Recherche Médicale U603, Universite Paris Descartes, and Centre National de la Recherche Scientifique, UMR 8154, 75006 Paris, France
J Neurosci 29:2043-52. 2009..Stimulation of the olfactory nerve induced similar population bursts and activated ET cells at a lower threshold than mitral cells, suggesting ..
- Cytoskeletal organization of the developing mouse olfactory nerve layerMichael R Akins
Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Comp Neurol 494:358-67. 2006Olfactory sensory neuron (OSN) axonal extension and targeting occur within the olfactory nerve layer (ONL) of the olfactory bulb (OB)...
- [Researchers of the olfactory nerve function were awarded the Medicine and Physiology Nobel prize]Matti Jokelainen
Suomen Terveystalo Oyj, Hemon lääkärikeskus, Lahti
Duodecim 120:2865-7. 2004
- Microglial/macrophage cells in mammalian olfactory nerve fasciclesLaura J Smithson
Department of Anatomy and Cell Biology, Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
J Neurosci Res 88:858-65. 2010..markers Iba1 and annexin A3, and reactivity to bulbectomy (in adult rats), these cells found within the olfactory nerve fascicles of both mammalian species meet several important criteria for their designation as microglia/..
- Thallium transport and the evaluation of olfactory nerve connectivity between the nasal cavity and olfactory bulbYayoi Kinoshita
Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920, Japan
Chem Senses 33:73-8. 2008Little is known regarding how alkali metal ions are transported in the olfactory nerve following their intranasal administration...
- Abnormalities of axon growth in human olfactory mucosaEric H Holbrook
Department of Otolaryngology, MA Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Laryngoscope 115:2144-54. 2005..However, detailed analysis of the subepithelial tissue with specific attention to the fascicles of the olfactory nerve and abnormalities of axonal growth may improve the correlation of histopathology with sensory function.
- Odor detection ability and thallium-201 transport in the olfactory nerve of traumatic olfactory-impaired miceHideaki Shiga
Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920, Japan
Chem Senses 33:633-7. 2008Although olfactory nerve damage is a contributing factor in the diagnosis of posttraumatic olfactory loss, at present, there are no methods to directly assess injury to these nerves...
- CRBP I and CRABP I localisation during olfactory nerve developmentA L Gustafson
Department of Pharmaceutical Bioscience, Division of Toxicology, Uppsala Biomedical Centre, Uppsala University, Box 594, 751 24, Uppsala, Sweden
Brain Res Dev Brain Res 114:121-6. 1999..Our results indicate that RA produced by the CRBP I-expressing 'glia-like' cells may act as a neurotrophic factor for the CRABP I-expressing immature olfactory axons...
- Axonal transport of rubidium and thallium in the olfactory nerve of miceYousuke Kanayama
School of Health Sciences, Faculty of Medicine, Kanazawa University, Ishikawa, Japan
Nucl Med Biol 32:505-12. 2005..administration of radioactive (86)Rb(+) and (201)Tl(+) in mice, we observed this direct transport via the olfactory nerve pathway...
- Delayed olfactory nerve regeneration in ApoE-deficient miceBritto P Nathan
Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
Brain Res 1041:87-94. 2005..OB) following olfactory epithelium (OE) lesion in mice, and hypothesized that apoE may play a vital role in olfactory nerve (ON) regeneration...
- Neurotrophic effect of gonadotropin-releasing hormone on neurite extension and neuronal migration of embryonic gonadotropin-releasing hormone neurons in chick olfactory nerve bundle cultureYoh Ichiro Kanaho
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
J Neurosci Res 87:2237-44. 2009..study the role of GnRH in the migratory process of GnRH neurons, we established an in vitro chick embryonic olfactory nerve bundle explant model. Embryonic day 7...
- Nicotinic receptor-mediated filtering of mitral cell responses to olfactory nerve inputs involves the α3β4 subtypeRinaldo D D'Souza
Department of Physiology and Biophysics and Neuroscience Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
J Neurosci 32:3261-6. 2012..nAChRs) in regulating the responses of mitral cells (MCs), the output neurons of the olfactory bulb, to olfactory nerve input...
- Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathwayDan B Renner
Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, 640 Jackson St, St Paul, MN 55101, USA
Neurosci Lett 513:193-7. 2012..study examined delivery of fluorescently labeled siRNA from the nasal cavity to the olfactory bulbs via the olfactory nerve pathway...
- Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cellsQ Yuan
Laboratory for Neuronal Circuit Dynamics, RIKEN Brain Science Institute, Wako Shi, Saitama, 351 0198, Japan
J Neurophysiol 95:3097-104. 2006..Here we characterized a slow mGluR1-mediated potential that was evoked by high-frequency (100-Hz) olfactory nerve (ON) stimulation in the presence of NBQX and D-APV, blockers of ionotropic glutamate receptors, and that was ..
- Use of thallium transport to visualize functional olfactory nerve regeneration in vivoHideaki Shiga
Department of Otorhinolaryngology Head and Neck Surgery, Kanazawa University, Kahokugun, Ishikawa, Japan
Rhinology 47:460-4. 2009To image olfactory nerve regeneration in vivo using a high-resolution gamma cam- era and radiography after nasal administration of thallium-201 (olfacto-scintigraphy).
- Olfactory nerve recovery following mild and severe injury and the efficacy of dexamethasone treatmentMasayoshi Kobayashi
Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0551, USA
Chem Senses 34:573-80. 2009To investigate factors that influence the degree of neural regeneration and recovery, we studied 2 olfactory nerve injury models...
- Evaluation of the olfactory nerve transport function by SPECT-MRI fusion image with nasal thallium-201 administrationHideaki Shiga
Department of Otorhinolaryngology Head and Neck Surgery, Kanazawa Medical University, Kahokugun, Ishikawa, Japan
Mol Imaging Biol 13:1262-6. 2011..The aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 ((201)Tl) administration...
- Rhinotopy is disrupted during the re-innervation of the olfactory bulb that follows transection of the olfactory nerveM D Christensen
Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Chem Senses 26:359-69. 2001Re-innervation of the olfactory bulb was investigated after transection of the olfactory nerve using monoclonal antibody RB-8 to assess whether rhinotopy of the primary olfactory projection is restored...
- Usefulness and feasibility of psychophysical and electrophysiological olfactory testing in the rhinology clinicP Rombaux
Department of Otorhinolaryngology, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
Rhinology 47:28-35. 2009..The purpose of this study is to assess the usefulness and feasibility of these diagnostic tools in the rhinology clinic and to correlate these results to the olfactory disorder aetiology...
- Theta bursts in the olfactory nerve paired with beta-adrenoceptor activation induce calcium elevation in mitral cells: a mechanism for odor preference learning in the neonate ratQi Yuan
University of California at San Diego, La Jolla, California 92093, USA
Learn Mem 16:676-81. 2009..Here a mechanism for enhanced mitral cell signaling is described. Theta bursts in the olfactory nerve (ON) produce long-term potentiation (LTP) of glomerular excitatory postsynaptic potentials (EPSPs) and of ..
- Signal-to-noise ratio of chemosensory event-related potentialsSanne Boesveldt
Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
Clin Neurophysiol 118:690-5. 2007..We investigated the influence of the number of stimuli on signal-to-noise (S/N) ratio of CSERP...
- Axon fasciculation in the developing olfactory nerveAlexandra M Miller
Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Neural Dev 5:20. 2010..While regional segregation occurs in the mesenchyme, the final convergence of OR-specific subpopulations does not occur until the axons reach the inner nerve layer of the OB...
- Calcium signaling in mitral cell dendrites of olfactory bulbs of neonatal rats and mice during olfactory nerve Stimulation and beta-adrenoceptor activationQi Yuan
Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, Wako Shi, Saitama, 351 0198, Japan
Learn Mem 11:406-11. 2004Synapses formed by the olfactory nerve (ON) provide the source of excitatory synaptic input onto mitral cells (MC) in the olfactory bulb...
- Olfactory system involvement in natural scrapie diseaseCristiano Corona
CEA, Italian Reference Laboratory for TSE, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Turin, Italy
J Virol 83:3657-67. 2009..infection by prions following intracerebral challenge suggested a potential centrifugal spread along the olfactory nerve fibers of the pathological prion protein (PrP(Sc))...
- The influence of training on chemosensory event-related potentials and interactions between the olfactory and trigeminal systemsAndrew Livermore
School of Social Sciences and Liberal Studies, Charles Sturt University, Bathurst, NSW 2790, Australia
Chem Senses 29:41-51. 2004..This was supported by a significant decrease of amplitudes of the event-related potentials at frontal recording sites following training with the test odor only..
- BIG-2 mediates olfactory axon convergence to target glomeruliTomomi Kaneko-Goto
Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351 0198, Japan
Neuron 57:834-46. 2008..These results suggest that BIG-2 is one of the axon guidance molecules crucial for the formation and maintenance of functional odor map in the olfactory bulb...
- Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cordT Imaizumi
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 18:6176-85. 1998..These data support the conclusion that transplantation of neonatal OECs results in quantitatively extensive and functional remyelination of demyelinated dorsal column axons...
- Activation of the Wnt/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cellsYa Zhou Wang
Department of Cell Biology and Human Anatomy, University of California, Davis, School of Medicine, and Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, California 95817, USA
Dev Dyn 237:3157-68. 2008..During early postnatal development, betagal+ cells were located in the inner olfactory nerve layer (ONLi) and co-labeled with olfactory ensheathing cell (OEC) markers S100beta and NPY but not with ..
- Olfactory nerve--a novel invasion route of Neisseria meningitidis to reach the meningesHong Sjölinder
Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
PLoS ONE 5:e14034. 2010..Taken together, N. meningitidis is able to pass directly from nasopharynx to meninges through the olfactory nerve system. This study enhances our understanding how N. meningitidis invades the meninges...
- Role of interleukin-15 in the development of mouse olfactory nerveTsuyoshi Umehara
Department of Otorhinolaryngology, Faculty of Medicine, Shimane University, Izumo, Japan
Congenit Anom (Kyoto) 49:253-7. 2009..Adult IL-15R alpha knockout mice had fewer mature olfactory neurons and proliferating cells than wild-type. Our results suggest that IL-15 plays an important role in regulating cell proliferation in olfactory neurogenesis...
- Glutamate and synaptic plasticity at mammalian primary olfactory synapsesM Ennis
Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201, USA
Ann N Y Acad Sci 855:457-66. 1998Glutamate is the transmitter at synapses from the olfactory nerve (ON) to mitral (Mi)/tufted cells, but very little is known about the functional properties of this synapse...
- Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neuronsP R Kramer
Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
Genes Dev 14:1824-34. 2000..These results demonstrate that NELF plays a role as a common guidance molecule for olfactory axon projections and subsequently, either directly or indirectly, in the neurophilic migration of LHRH cells...
- Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulbSusan J Harrison
Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
Cereb Cortex 18:1604-17. 2008..In addition, the olfactory nerve failed to extend past the ventral-medial region of the OB in Sall1-deficient animals...
- Microsurgical anatomic features of the olfactory nerve: relevance to olfaction preservation in the pterional approachSalvatore Cardali
Neurosurgical Clinic, Department of Neurosciences, University of Messina Medical School, Messina, Italy
Neurosurgery 57:17-21; discussion 17-21. 2005....
- Intercellular interactions in the mammalian olfactory nerveKaren J Blinder
Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
J Comp Neurol 466:230-9. 2003..We recently demonstrated ephaptic interactions between these axons in the olfactory nerve layer, the layer of the olfactory bulb in which the axon fascicles interweave and rearrange extensively...
- Olfactory bulb DA receptors may be located on terminals of the olfactory nerveW T Nickell
Department of Anatomy, University of Cincinnati College of Medicine, OH 45267
Neuroreport 2:9-12. 1991..3H]SCH23390 was slightly above background and was distributed through all layers of the bulb except the olfactory nerve layer...
- Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cellsMatthew Ennis
Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
J Neurophysiol 95:2233-41. 2006..on the apical dendrites of olfactory bulb mitral cells and thus may be activated by glutamate released from olfactory nerve (ON) terminals. Previous studies have shown that mGluR1 agonists directly excite mitral cells...
- Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cordT Kato
Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan
Glia 30:209-18. 2000..These results provide evidence that adult human OECs are able to produce Schwann cell-like myelin sheaths around demyelinated axons in the adult mammalian CNS in vivo...
- Expression of the dm-20 isoform of the plp gene in olfactory nerve ensheathing cells: evidence from developmental studiesP J Dickinson
Applied Neurobiology Group, University of Glasgow Veterinary School, Bearsden, UK
J Neurocytol 26:181-9. 1997..plp gene activity was present in the non-myelinated olfactory nerve layer of the bulb from E14 through to adult ages...
- Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in the developing olfactory bulb and subventricular zone rostral extensionSilvana S Gomes
Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
J Neurosci Res 73:471-80. 2003..They also raise the possibility that a minor fraction of OB oligodendrocytes might derive from the SVZ-RE...
- Interplay between local GABAergic interneurons and relay neurons generates gamma oscillations in the rat olfactory bulbSamuel Lagier
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 75724 Paris, France
J Neurosci 24:4382-92. 2004..We showed that a single and brief electrical stimulation of olfactory nerve elicited LFP oscillations in the mitral cell body layer lasting >1 sec...
- Olfactory nerve stimulation-induced calcium signaling in the mitral cell distal dendritic tuftQ Yuan
Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, Saitama, Japan
J Neurophysiol 95:2417-26. 2006Olfactory receptor neuron axons form the olfactory nerve (ON) and project to the glomerular layer of the olfactory bulb, where they form excitatory synapses with terminal arborizations of the mitral cell (MC) tufted primary dendrite...
- Structure of intraglomerular dendritic tufts of mitral cells and their contacts with olfactory nerve terminals and calbindin-immunoreactive type 2 periglomerular neuronsK Kosaka
Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Comp Neurol 440:219-35. 2001..In particular, the relationships of BDA-labeled tufts with olfactory nerve (ON) terminals and processes of calbindin D-28K-immunoreactive (CB-IR) cells were investigated with confocal ..
- The relationship of particle size to olfactory nerve uptake of a non-soluble form of manganese into brainLaurence D Fechter
Department of Occupational and Environmental Health and Pharmaceutical Sciences, College of Pharmacy, Oklahoma Center for Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
Neurotoxicology 23:177-83. 2002..Recent data suggest that a third route of exposure, transport by the olfactory nerve directly to the brain, might have importance in toxicology since such a route would bypass liver uptake and ..
- Expression of netrin-1 and netrin-1 receptor, DCC, in the rat olfactory nerve pathway during development and axonal regenerationL Astic
Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS UMR 5020, Université VClaude Bernard Lyon 1, France
Neuroscience 109:643-56. 2002..This expression was transient since from embryonic day 16 onwards, DCC was no longer detected along the olfactory nerve path...
- Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulbJohn E Rash
Department of Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
J Neurocytol 34:307-41. 2005..immunofluorescence microscopy to examine Cx36, Cx43 and Cx45 protein in gap junctions in olfactory mucosa, olfactory nerve and OB in adult rats and mice and early postnatal rats...
- Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminalsGabe J Murphy
Neuroscience Graduate Program and Department of Neuroscience, University of California, San Diego School of Medicine, La Jolla, California 92093 0608, USA
J Neurosci 24:3023-30. 2004..firing of ORNs is transmitted to the brain, we examined the properties of glutamate release from olfactory nerve (ON) terminals in slices of the rat olfactory bulb...
- Semaphorin 3A is required for guidance of olfactory axons in miceG A Schwarting
The Shriver Center, Waltham, Massachusetts 02452, USA
J Neurosci 20:7691-7. 2000..These observations indicate that Sema3A expression by ensheathing cells plays an important role in guiding olfactory axons into specific compartments of the OB...
- Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAMAndreas Walz
The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
Mol Cell Neurosci 32:1-14. 2006..Instead, OCAM is required for establishing or maintaining the compartmental organization and the segregation of axodendritic and dendrodendritic synapses within glomeruli...
- EphB2 and two of its ligands have dynamic protein expression patterns in the developing olfactory systemJ A St John
Neurodevelopment Laboratory, Department of Anatomical Sciences, The University of Queensland, 4072, Brisbane, Australia
Brain Res Dev Brain Res 126:43-56. 2001....
- Reciprocal interactions between olfactory receptor axons and olfactory nerve glia cultured from the developing moth Manduca sextaEric S Tucker
Department of Cell Biology and Anatomy, University of Arizona, PO Box 245044, Tucson, AZ 85724 5044, USA
Dev Biol 260:9-30. 2003....
- Lymphatic vessels gain access to cerebrospinal fluid through unique association with olfactory nervesAndrei Zakharov
Neuroscience Research, Department of Laboratory Medicine and Pathobiology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
Lymphat Res Biol 2:139-46. 2004..Especially important is CSF transport through the cribriform plate in association with the olfactory nerves. This study examined the anatomical connections that link the CSF and extracranial lymphatics at the base of the brain...
- Axon behavior in the olfactory nerve reflects the involvement of catenin-cadherin mediated adhesionMichael R Akins
Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
J Comp Neurol 499:979-89. 2006..We demonstrate that axons remain restricted to the outer olfactory nerve layer (ONLo) until they are proximal to their target glomeruli, where they enter the inner ONL (ONLi), ..
- Imaging the olfactory tract (cranial nerve #1)Thierry P Duprez
Department of Radiology and Medical Imaging, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium
Eur J Radiol 74:288-98. 2010..Techniques for collecting quantitative data on olfactory bulb volume and on olfactory sulcus depth are described. At last, insights into functional imaging of olfactory sense are shown...
- [Axonal mRNAs: from histochemical visualization to functional analyses]Alain Trembleau
Equipe Avenir INSERM Développement et Plasticité des Réseaux Neuronaux, CNRS UMR 7102, Universite Pierre et Marie Curie Paris 6, Boîte 12, 9 Quai St Bernard, 75005 Paris, France
J Soc Biol 203:65-73. 2009..The aim of this paper is to illustrate, taking mainly the mouse olfactory system as an example, conceptual and methodological approaches developed in particular in my group, that aim at identifying the function of these axonal mRNAs...
- Target tissue influences the peripheral trajectory of mouse primary sensory olfactory axonsMelonie J Storan
Department of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
J Neurobiol 61:175-88. 2004....
- Defining the role of olfactory ensheathing cells in facilitating axon remyelination following damage to the spinal cordJ Gordon Boyd
Department of Anatomy and Cell Biology, Queen s University, Room 926, Botterell Hall, Kingston, ON, Canada K7L 3N6
FASEB J 19:694-703. 2005..Together with Schwann cells, OECs create a 3-dimensional matrix that provides a permissive microenvironment for successful axon regeneration in the adult mammalian central nervous system...
- LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cordJ G Boyd
Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada K7L 3N6
Proc Natl Acad Sci U S A 101:2162-6. 2004..These observations suggest that the role of OECs as the primary mediators of the beneficial effects on axon growth, myelination, and functional recovery after spinal cord injury may require re-evaluation...
- Promoting central nervous system regeneration: lessons from cranial nerve IMarc J Ruitenberg
Experimental and Regenerative Neuroscience EaRN, School of Anatomy and Human Biology M309, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
Restor Neurol Neurosci 26:183-96. 2008The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells...
- Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouseThomas Bozza
The Rockefeller University, New York, NY 10065, USA
Neuron 61:220-33. 2009..Axons from the two OSN types segregate already within the olfactory nerve and form distinct domains of glomeruli in the OB...
- Expression of EphA5 during development of the olfactory nerve pathway in ratJ A St John
Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
J Comp Neurol 416:540-50. 2000..The mechanisms responsible for persistent growth and guidance of primary olfactory axons along the olfactory nerve are unknown...
- Evaluation of olfactory nerve function after aneurysmal subarachnoid hemorrhage and clip occlusionJoost De Vries
Departments of Neurosurgery, Radboud University, Nijmegen, The Netherlands
J Neurosurg 107:1126-9. 2007In this study, the olfactory nerve function (ONF) in patients with an aneurysmal subarachnoid hemorrhage (SAH) who underwent neurosurgical clip occlusion for intracranial aneurysm was assessed pre- and postoperatively.
- The neural representation of odor is modulated by the presence of a trigeminal stimulus during odor encodingM Bensafi
Laboratoire Neurosciences and Systèmes Sensoriels, CNRS UMR5020, Universite Claude Bernard Lyon 1, 50, Avenue Tony Garnier, 69366 Lyon Cedex 07, France
Clin Neurophysiol 118:696-701. 2007..The present study set out to examine whether the presence of a pure trigeminal stimulus during odor encoding may modulate odor perception at both behavioral and cortical levels...
- The olfactory nerve has a role in the body temperature and brain cytokine responses to influenza virusVictor H Leyva-Grado
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, USA
Brain Behav Immun 24:281-8. 2010..To determine whether signals from the olfactory nerve influence the unfolding of the acute phase response (APR), we surgically transected the olfactory nerve in ..
- Evidence that olfactory sensitivities to calcium and sodium are mediated by different mechanisms in the goldfish Carassius auratusPeter C Hubbard
Centro de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8005 139 Faro, Portugal
Neurosci Lett 414:90-3. 2007..However, there seems to be a degree of overlap between the two mechanisms. The exact mechanisms involved, and their biological roles, remain to be established...
- Effect of ginkgo biloba and dexamethasone in the treatment of 3-methylindole-induced anosmia mouse modelChul Hee Lee
Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
Am J Rhinol 22:292-6. 2008..This study is designed to identify the effect of ginkgo biloba, an antioxidant that acts as a free radical scavenger, in the treatment of olfactory injury aggravated by dexamethasone...
- External tufted cells: a major excitatory element that coordinates glomerular activityAbdallah Hayar
Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
J Neurosci 24:6676-85. 2004..ET cells spontaneously fired rhythmic spike bursts in the theta frequency range and received monosynaptic olfactory nerve (ON) input. In contrast, all SA and most PG cells lacked monosynaptic ON input...
- Theoretical consideration of olfactory axon projection with an activity-dependent neural network modelHirokazu Tozaki
Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Mishima 411 8540, Japan
Mol Cell Neurosci 26:503-17. 2004..Taken together, the activity-dependent targeting of olfactory axons seems to be a simple probable mechanism that can provide a unified explanation of glomerular formation...
- [From nose to brain : a subtle connection]Aurélie Mouret
Med Sci (Paris) 23:252-5. 2007
- 3D atlas describing the ontogenic evolution of the primary olfactory projections in the olfactory bulb of Xenopus laevisArnaud Gaudin
Centre des Sciences du Goût Unité Mixte de Recherche 5170 Centre National de la Recherche Scientifique Université de Bourgogne Institut National de la Recherche Agronomique, F 21000 Dijon, France
J Comp Neurol 489:403-24. 2005..We generated a 3D atlas at several stages which are representative of the reorganization process. This will be a useful tool for future studies of development and function...
- Olfactory and sensory attributes of the noseBozena B Wrobel
Department of Otolaryngology Head and Neck Surgery, University of Southern California, 1520 San Pablo Street, Suite 4600, Los Angeles, CA 90033, USA
Otolaryngol Clin North Am 38:1163-70. 2005..Healthy olfactory mucosa allows for appreciation of pleasant aromas and food flavors. The olfactory nerve, in concert with the trigeminal nerve, serves as a main interpreter and modulator of chemosensory information...
- The shape of the olfactory bulb influences axon targetingFatemeh Chehrehasa
Brain Growth and Regeneration Lab, Discipline of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
Brain Res 1169:17-23. 2007..To begin to understand the role of the olfactory bulb in the formation of the olfactory nerve pathway, we developed a model whereby the gross shape of the bulb in the P2-IRES-tau-LacZ line of mice was ..
- Early upregulation in nasal epithelium and strong expression in olfactory bulb glomeruli suggest a role for Aquaporin-4 in olfactionJan Gunnar Sørbø
Center for Molecular Biology and Neuroscience CMBN, University of Oslo, Norway
FEBS Lett 581:4884-90. 2007..However, in the nasal epithelium AQP4 is upregulated as early as in the brain. Furthermore, AQP4 is strongly expressed in the glomerulus, the synaptic unit of the olfactory bulb, suggesting a role for AQP4 in olfactory function...
- Activation of postsynaptic GABAB receptors modulates the bursting pattern and synaptic activity of olfactory bulb juxtaglomerular neuronsNikolay Karpuk
Deptepartment of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
J Neurophysiol 99:308-19. 2008..that gamma-aminobutyric acid (GABA) released from PG neurons presynaptically inhibits glutamate release from olfactory nerve terminals via activation of GABA(B) receptors (GABA(B)-Rs)...
- Optical mapping of spatiotemporal emergence of functional synaptic connections in the embryonic chick olfactory pathwayK Sato
Department of Physiology, Tokyo Medical and Dental University, Graduate School and Faculty of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
Neuroscience 144:1334-46. 2007..we elucidate the functional maturation of forebrain circuits by investigating neural networks related to the olfactory nerve (N. I) of chicken embryo. In the isolated N...
- Multipotent stem and progenitor cells of the olfactory epitheliumI V Viktorov
V P Serbsky State Research Center of Social and Forensic Psychiatry, Moscow
Bull Exp Biol Med 142:495-502. 2006....
- Signal processing with temporal sequences in olfactory systemsAndrzej G Lozowski
Department of Electrical and Computer Engineering, Southern Illinois University, Edwardsville, IL 62026, USA
IEEE Trans Neural Netw 15:1268-75. 2004..Ultimately, such pattern matching results in ability to recognize odors and offer a hypothetic model for signal processing occurring in the primary stage of the olfactory system...
- Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functionsOliver Pfaar
Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, D 01307 Dresden, Germany
Chem Senses 31:27-31. 2006..This might become a valuable model of hyposmia for future investigations...
- Development of wiring specificity in the olfactory systemTakaki Komiyama
Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA, 94305, USA
Curr Opin Neurobiol 16:67-73. 2006....
- [Recent progress in diagnosis of otorhinolaryngologic diseases: brain map--basic studies on dysosmia related olfactory sense]Kensaku Mori
Nihon Jibiinkoka Gakkai Kaiho 108:1067-70. 2005
- Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory systemAlexandra Veyrac
UMR 5020, Neurosciences et Systemes Sensoriels, CNRS Universite Claude Bernard Lyon 1, 50 avenue Tony Garnier, F 69366 Lyon Cedex 07, France
Eur J Neurosci 21:2635-48. 2005....
- Retinoic acid receptor-dependent survival of olfactory sensory neurons in postnatal and adult miceMaria Hägglund
Department of Molecular Biology, Umea University, SE901 87 Umea, Sweden
J Neurosci 26:3281-91. 2006..Collectively, the results provide evidence for a role of locally regulated retinoid metabolism in neuroprotection and in determining population size of neurons at a late stage of neural circuit formation...
- Formation of glomerular maps in the olfactory systemJörg Strotmann
University of Hohenheim, Institute of Physiology, Garbenstrasse 30, D 70599 Stuttgart, Germany
Semin Cell Dev Biol 17:402-10. 2006..While the initial process of glomerulization requires mainly molecular determinants, activity-dependent processes lead to a refinement of glomerular organization...
- Temporal profiling of gene expression during neurogenesis and remodeling in the olfactory epithelium at short intervals after target ablationThomas V Getchell
Department of Physiology, University of Kentucky, Lexington, 40536 0230, USA
J Neurosci Res 80:309-29. 2005..These studies are an important first step in defining early time-dependent changes in gene expression after target ablation that lead to neurogenesis in the olfactory sensory epithelium...
- Odor-driven activity in the olfactory cortex of an in vitro isolated guinea pig whole brain with olfactory epitheliumTakahiro Ishikawa
Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
J Neurophysiol 97:670-9. 2007..This study provides the basis for clarifying the sequence of neural activities underlying odor information processing in the brain in vitro following natural olfactory stimulation...
- Imaging of olfaction and gustationIvanka Savic-Berglund
Karolinska Institutet Centre of Gender Related Medicine, Stockholm, Sweden
Nutr Rev 62:S205-7; discussion S224-41. 2004..More irritating, burning odors (e.g., acetone) project via the trigeminal rather than the olfactory nerve and induce changes in the brain stem and the cortex...
- Implantation of a scaffold following bulbectomy induces laminar organization of regenerating olfactory axonsFatemeh Chehrehasa
Brain Growth and Regeneration Lab, Discipline of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
Brain Res 1119:58-64. 2006Primary olfactory axons expressing different odorant receptors are interspersed within the olfactory nerve. However, upon reaching the outer nerve fiber layer of the olfactory bulb they defasciculate, sort out, and refasciculate prior to ..
- Characterization of somatostatin- and cholecystokinin-immunoreactive periglomerular cells in the rat olfactory bulbMaría Gutierrez-Mecinas
Departamento de Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Valencia, E 46100 Burjasot, Spain
J Comp Neurol 489:467-79. 2005..of the olfactory bulb (OB) that modulate the first synaptic relay of the olfactory information from the olfactory nerve to the dendrites of the bulbar principal cells...
- The alteration of odor-induced c-Fos immunoreactivity in the rat olfactory bulb after olfactory nerve transectionMasahiro Kawamoto
Department of Otolaryngology and Sensory Organ Surgery E8, Osaka University School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 5650871, Japan
J Neurol 250:51-4. 2003We used the rats in which one olfactory nerve had been transected and observed the odor (Propionic acid) -induced c-Fos immunoreactivity in the bulb at different times (2, 4, 8 weeks) after nerve transection...
- The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouseGiovanni Levi
Laboratoire de Physiologie Général et Comparée, CNRS, UMR 8572, Museum national d histoire naturelle, Paris, France
Mol Cell Neurosci 22:530-43. 2003..Thus, the absence of Dlx5 in the OB does not per se prevent ORN axon ingrowth. In conclusion, Dlx5 plays major roles in the connectivity of ORN axons and in the differentiation of OB interneurons...
- Development of the primary olfactory pathwayHelen Treloar; Fiscal Year: 2005..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
- Cognitive modulation of primary sensory processing in olfactory receptor neuronsJohn P McGann; Fiscal Year: 2013..odor without the tone evokes much less presynaptic calcium influx and less neurotransmitter release from the olfactory nerve than when the odor follows the cue...
- Mechanisms of prion transportRichard A Bessen; Fiscal Year: 2013..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion ..
- fMRI Correlates of Olfactory and Visual Cues in Tobacco SmokingSTEVEN BRADLEY LOWEN; Fiscal Year: 2010..The use of new brain mapping tools will allow such relationships to be identified. ..
- Acitivity-Dependent Plasticity of Sensory Synapses in the Olfactory BulbHong Wei Dong; Fiscal Year: 2009..My new preliminary data demonstrate that brief, high frequency bursts (theta-burst stimulation, TBS) of olfactory nerve (ON) stimulation produce robust, long-term changes in the strength of neurotransmission at ON synapses in the ..
- The Olfactory NerveCharles A Greer; Fiscal Year: 2013..What is the relationship of individual axons to the olfactory ensheathing cells along the course of the olfactory nerve and olfactory nerve layer? How are growth cones distributed and organized in the fascicles both during early ..
- Olfactory Support CellsTimothy S McClintock; Fiscal Year: 2010..chemicals, in part by generating a favorable microenvironment and retaining the ability to replace damaged olfactory nerve cells even as aging occurs...
- Biophysics of forward and lateral connections in a genetically-tractable circuitHokto Kazama; Fiscal Year: 2010..transmission will be characterized by recording from identified PNs while electrically stimulating the olfactory nerve. Interglomerular interactions among PNs and LNs will be characterized using genetically encoded "triggers" to ..
- Enhancement of olfactory neuron survival and targeting via odorant exposureEric H Holbrook; Fiscal Year: 2010..tested through three specific aims all utilizing the mouse model of recovery from methyl bromide exposure or olfactory nerve transection...
- Extracellular Matrix Mediates Axonal Integrity Following Brain InjuryLinda L Phillips; Fiscal Year: 2013..TBI : 1) to document OPN/MMP2,9 during axonal injury within fiber environments enriched in unmyelinated (ON, olfactory nerve) and myelinated fibers (IC, internal capsule), and determine if OPN KO and MMP9KO alters these changes, 2) to ..
- Depth-resolved Optical Imaging of Neural Action PotentialsTaner Akkin; Fiscal Year: 2013..for depth-resolved imaging of neural activity in various preparations including squid giant axon, pike olfactory nerve, and salamander and mouse retinas...
- A Role for Migrating Olfactory Placode Cells in Olfactory Nerve DevelopmentAlexandra Miller; Fiscal Year: 2010..Specifically, this proposal focuses on the development of the primary olfactory nerve pathway (ONP), which connects the olfactory sensory neurons (OSNs), which reside in the OE, to the olfactory ..
- Relating Synaptic Plasticity to Changes in Odor Representation and PerceptionJohn P McGann; Fiscal Year: 2012..that the olfactory system exhibits rapid feedback presynaptic inhibition of transmitter release from the olfactory nerve. I hypothesize that the rapid plasticity of this circuit provides adaptive gain control for the primary ..
- Neuron Glial InteractionsCharles A Greer; Fiscal Year: 2010DESCRIPTION (provided by applicant): The mechanisms influencing the capacity of the olfactory nerve for ongoing replacement of olfactory sensory neuron axons is not well understood...
- DEVELOPMENT AND MIGRATION OF LHRH NEURONSRobert Norgren; Fiscal Year: 1999..Recent studies have demonstrated that X-linked Kallmann's disease is due to a failure of the olfactory nerve to enter the telencephalon and LHRH neurons to migrate into the brain...
- LOCUS COERULEUS MODULATION OF OLFACTORY NETWORK FUNCTIONMichael Shipley; Fiscal Year: 2005..in vivo has a dramatic 'modulatory' action increasing mitral cells (MCs) responses to weak but not strong olfactory nerve (ON) shocks...
- NEUROTROPHINS IN OLFACTORY DEVELOPMENTKathleen Guthrie; Fiscal Year: 2002..mRNAs are expressed by olfactory sensory neurons and if neurotrophin proteins are localized within olfactory nerve projections...
- NUTRITIONAL MODULATION OF OLFACTORY SYSTEM INTEGRITYNANCY RAWSON; Fiscal Year: 1999..or IGF-I mRNA, or their receptor proteins or mRNAs in the olfactory bulb and epithelium change in response to olfactory nerve section; (4) Determine whether altered nutritional status (PR and StD) influences repair of the olfactory ..
- HEAT SHOCK PROTEINS IN THE OLFACTORY EPITHELIUMVIRGINIA CARR; Fiscal Year: 1993..and physiological stresses (olfactory bulbectomy and bulbectomy-induced synaptic target deprivation, olfactory nerve axotomy neonatal naris closure, decreased O2, and hyperthermia)...
- MODEL TO STUDY THE PHYSIOLOGY OF SMALL NERVE FIBERSGEORGE KRACKE; Fiscal Year: 1993..The garfish olfactory nerve is a unique experimental model system in which to study the physiology of C fibers...
- ODOR RESPONSES AND ANATOMY OF OLFACTORY BULB NEURONSKathryn Hamilton; Fiscal Year: 1991..except in one pattern evoked by high odor concentration, unlike in responses to electrical stimulation of the olfactory nerve or tract. In the responses to electrical stimulation, excitation always preceded inhibition...
- COMPLEX LIPID METABOLISM IN THE AXONRobert Gould; Fiscal Year: 1991..By studying the lipid enzymes from axoplasm (squid giant axons) and axolemma (frog olfactory nerve) in a comparative way, we can begin to understand how activities of the key axonal enzymes might be regulated ..
- Relating Synaptic Plasticity to Changes in Odor Representation and PerceptionJOHN MCGANN; Fiscal Year: 2009..that the olfactory system exhibits rapid feedback presynaptic inhibition of transmitter release from the olfactory nerve. I hypothesize that the rapid plasticity of this circuit provides adaptive gain control for the primary ..
- Cyclic nucleotide modulation of olfactory sensory inputGABE MURPHY; Fiscal Year: 2003..To do this, neurons that receive synaptic input from the olfactory nerve will be whole cell patch clamped...
- MECHANISMS OF AXONAL PLASTICITY FOLLOWING INJURYCHARLES GREER; Fiscal Year: 2002..the hypothesis that specific subpopulations of glial cells, in particular the ensheathing cells of the olfactory nerve, may provide an optimal substrate...
- CYTOSKELETON OF THE OLFACTORY NEURONPaul Burton; Fiscal Year: 1990..The substructure of isolated neurofilaments and neurofilaments in situ will be studied. Homogenates of olfactory nerve will be examined by SDS disc and slab gel electrophoresis to characterize the kinds of proteins present, ..
- Interaction of ApoE with Estrogen in the Olfactory SystemBritto Nathan; Fiscal Year: 2008..This hypothesis is based on the following observations. First, olfactory nerve regeneration was severely delayed in apoE-gene knockout (KO) mice as compared to wild-type (WT) litermates...
- DEAFFERENTATION OF THE OLFACTORY BULB IN ADULT ZEBRAFISHChristine Byrd; Fiscal Year: 2004..2: Does removal of only odor-induced activity cause the same changes in the olfactory bulb as physical deafferentation? Specific Aim 3: Does transection of the olfactory nerve induce the same effect as ablation of the olfactory organ?
- Strategies for Restoring Olfactory NeurogenesisJAMES SCHWOB; Fiscal Year: 2004..abstract_text> ..
- Gene Expression Profiling of Adult Olfactory Stem and Progenitor CellsJAMES SCHWOB; Fiscal Year: 2008..adult stem cells resemble in both molecular and functional terms, give rise to the specialized glia of the olfactory nerve, which may promote functional recovery after spinal cord injury...
- DEVELOPMENT OF THE PRIMARY OLFACTORY PROJECTIONJAMES SCHWOB; Fiscal Year: 2005..Attempts to foster recovery in the clinical population require an understanding in depth of the inherent limits and capacities for regeneration. ..
- DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISHKATHLEEN WHITLOCK; Fiscal Year: 2004..These sensory axons create a pathway, the olfactory nerve, connecting the peripheral and central nervous system...
- Mechanisms of prion transportRICHARD BESSEN; Fiscal Year: 2008..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion ..
- Development of gonadotropin releasing hormone cellsKATHLEEN WHITLOCK; Fiscal Year: 2009..is likely only a consequence of the disruption in the migration of GnRH cells to the hypothalamus along the olfactory nerve. Consistent with this interpretation we have shown, in zebrafish, that mutant embryos lacking their pituitary ..
- THYROID HORMONE REGULATION OF NEURAL DEVELOPMENTGAIL BURD; Fiscal Year: 2002..The goal of this research is to provide insight into thyroid hormone regulation of olfactory system development using an experimentally-favorable model system. ..
- Integrative mechanisms of cortical circuitsGORDON MURRAY SHEPHERD; Fiscal Year: 2010..The results will therefore suggest new principles for the functioning of cortical modules, and for the neural basis of normal odor processing. ..
- Targeting the Apical Surface of Human Airway EpitheliaPAOLA DRAPKIN; Fiscal Year: 2003..The major goals of this proposal are to generate candidate-targeting molecules with the hope of increasing efficiency of gene transfer vectors to the airways. ..
- Distribution and Role of CaMKII in Mouse Olfactory BulbDong Jing Zou; Fiscal Year: 2003..In particular, we will investigate whether CaMKII activity regulates the development of granule cells, the most abundant neurons in the olfactory bulb. ..
- Development of the primary olfactory pathwayHelen Treloar; Fiscal Year: 2009..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
- OLFACTORY AXON REGULATE OLFACTORY BULB CYTOGENESISQizhi Gong; Fiscal Year: 2003..The determination of critical regulatory steps during cytogenesis will facilitate further analysis of the molecular players involved in this process. ..
- PROPERTIES OF OLFACTORY RECEPTORS - NEURAL REGENERATIONRICHARD COSTANZO; Fiscal Year: 2009..An established model of olfactory nerve injury will be used to investigate the role of MMPs following nerve injury and recovery processes during the ..
- NPY DEPRESSION OF HIPPOCAMPAL EPILEPSYAnthony van den Pol; Fiscal Year: 2002..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
- ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONSThomas Getchell; Fiscal Year: 2005..Understanding the signaling regulating neurogenesis in the OE will yield insights into mechanisms for restoring olfactory function compromised by aging, trauma, and neurodegenerative diseases. ..
- FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAYIgor Kratskin; Fiscal Year: 2003..These studies will demonstrate the function of taurine in the olfactory epithelium and potential mechanisms of taurine action on primary olfactory neurons. ..
- Cytokine activation of neuronsCAROL REISS; Fiscal Year: 2009..They elucidate previously unsuspected interactions between the immune system and the central nervous system. ..
- Extracellular matrix in chloracetanilide carcinogenesisMary Beth Genter; Fiscal Year: 2004..abstract_text> ..
- Sphingolipid signaling in olfactory mucosaMary Beth Genter; Fiscal Year: 2004..abstract_text> ..
- DEVELOPMENT OF THE GUSTATORY SYSTEMRICHARD NORTHCUTT; Fiscal Year: 2005..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
- IMPROVED CELL COUNTING USING THE OPTICAL DISECTORCHRISTOPHER VON BARTHELD; Fiscal Year: 2004....
- Gap Junctions and Connexins in Developing CNSJOHN RASH; Fiscal Year: 2005....
- OLFACTION IN EPILEPSYRICHARD DOTY; Fiscal Year: 2004..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
- NEURAL CIRCUITRY MEDIATING SUCROSE INDUCED ANALGESIAMatthew Ennis; Fiscal Year: 2003..This work will lead to a better understanding of neural circuits controlling taste and pain and how these circuits regulate analgesia in newborns. ..
- PHYSIOLOGICAL ANALYSIS OF THE OLFACTORY PROJECTIONSJohn Scott; Fiscal Year: 2006..These results will be of importance for understanding the sense of smell. ..
- Odorant Receptors and Functional MappingThomas Bozza; Fiscal Year: 2004..The general approach of targeting expression of exogenous proteins (e.g., genetically encoded optical indicators) to defined neuronal populations could provide new methods to monitor neuronal activity in intact neuronal circuits. ..
- Analgesic effects of adrenal chromaffin cell transplantsGeorge Pappas; Fiscal Year: 2007..abstract_text> ..
- Genetic approaches to image neural activity in the brainThomas Bozza; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Senselab: Integration of Multidisciplinary Sensory DataGordon Shepherd; Fiscal Year: 2008..abstract_text> ..
- DEVELOPMENT OF OLFACTORY CONNECTIONSQizhi Gong; Fiscal Year: 2007..of the differentiation and the targeting of the mitral cell dendrites, the postsynaptic partner of the olfactory nerve. We propose to investigate the following hypotheses concerning the control of mitral/tufted cell ..
- Connexins in Neuronal and Glial Gap Junctions in the Central Nervous SystemJOHN RASH; Fiscal Year: 2007..abstract_text> ..
- GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUSAnthony van den Pol; Fiscal Year: 2008..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
- VSV INFECTION OF THE CENTRAL NERVOUS SYSTEMCAROL REISS; Fiscal Year: 2005..This work has both basic and clinical applications, as viral encephalitis and pathological changes in the BBB are important medical problems. ..
- REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENTAnthony S LaMantia; Fiscal Year: 2010....
- POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTIONRICHARD DOTY; Fiscal Year: 2005..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..