olfactory nerve

Summary

Summary: The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB.

Top Publications

  1. ncbi Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cord
    R Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, 6200 MD, Maastricht, The Netherlands
    Exp Neurol 200:89-103. 2006
  2. ncbi Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals
    M Ennis
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 86:2986-97. 2001
  3. ncbi Intranasal delivery of insulin via the olfactory nerve pathway
    Dan B Renner
    Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, St Paul, MN 55101, USA
    J Pharm Pharmacol 64:1709-14. 2012
  4. ncbi Neural regeneration and the peripheral olfactory system
    James E Schwob
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Anat Rec 269:33-49. 2002
  5. pmc Composition of the migratory mass during development of the olfactory nerve
    Alexandra M Miller
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 518:4825-41. 2010
  6. ncbi Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway
    Albrecht F Kiderlen
    Department of Infectious Diseases, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Parasitol Res 94:49-52. 2004
  7. pmc A balance of BMP and notch activity regulates neurogenesis and olfactory nerve formation
    Esther Maier
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 6:e17379. 2011
  8. ncbi Olfactory ensheathing cells: the primary innate immunocytes in the olfactory pathway to engulf apoptotic olfactory nerve debris
    Zhida Su
    Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Ministry of Education, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, China
    Glia 61:490-503. 2013
  9. pmc Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals
    Z Shao
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, 21201 MD, USA
    J Neurophysiol 101:1988-2001. 2009
  10. ncbi Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibres
    Ying Li
    Spinal Repair Unit, Institute of Neurology, University College London, London, United Kingdom
    Glia 52:245-51. 2005

Detail Information

Publications210 found, 100 shown here

  1. ncbi Olfactory ensheathing cells, olfactory nerve fibroblasts and biomatrices to promote long-distance axon regrowth and functional recovery in the dorsally hemisected adult rat spinal cord
    R Deumens
    Department of Psychiatry and Neuropsychology, Division Neuroscience, European Graduate School of Neuroscience EURON, University of Maastricht, 6200 MD, Maastricht, The Netherlands
    Exp Neurol 200:89-103. 2006
    Cellular transplantation, including olfactory ensheathing cells (OEC) and olfactory nerve fibroblasts (ONF), after experimental spinal cord injury in the rat has previously resulted in regrowth of severed corticospinal (CS) axons across ..
  2. ncbi Dopamine D2 receptor-mediated presynaptic inhibition of olfactory nerve terminals
    M Ennis
    Department of Anatomy and Neurobiology and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurophysiol 86:2986-97. 2001
    Olfactory receptor neurons of the nasal epithelium project via the olfactory nerve (ON) to the glomeruli of the main olfactory bulb, where they form glutamatergic synapses with the apical dendrites of mitral and tufted cells, the output ..
  3. ncbi Intranasal delivery of insulin via the olfactory nerve pathway
    Dan B Renner
    Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, St Paul, MN 55101, USA
    J Pharm Pharmacol 64:1709-14. 2012
    ..an investigation into the pathways by which intranasal administration delivers insulin to the CNS, this study has focused on the direct delivery of insulin from the olfactory mucosa to the olfactory bulbs via the olfactory nerve pathway.
  4. ncbi Neural regeneration and the peripheral olfactory system
    James E Schwob
    Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA
    Anat Rec 269:33-49. 2002
    ..e., the olfactory epithelium reconstitutes, the olfactory nerve regenerates, and the olfactory bulb is reinnervated, with a facility that is unique within the mammalian ..
  5. pmc Composition of the migratory mass during development of the olfactory nerve
    Alexandra M Miller
    Department of Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 518:4825-41. 2010
    The embryonic development of the olfactory nerve includes the differentiation of cells within the olfactory placode, migration of cells into the mesenchyme from the placode, and extension of axons by the olfactory sensory neurons (OSNs)...
  6. ncbi Balamuthia mandrillaris, an opportunistic agent of granulomatous amebic encephalitis, infects the brain via the olfactory nerve pathway
    Albrecht F Kiderlen
    Department of Infectious Diseases, Robert Koch Institute, Nordufer 20, 13353 Berlin, Germany
    Parasitol Res 94:49-52. 2004
    ..A similar invasion pathway has been described for N. fowleri. The data suggest that the olfactory nerve pathway is a likely route for natural infection of the brain by B. mandrillaris amebae.
  7. pmc A balance of BMP and notch activity regulates neurogenesis and olfactory nerve formation
    Esther Maier
    Umeå Center for Molecular Medicine, Umea University, Umea, Sweden
    PLoS ONE 6:e17379. 2011
    ..system has been thoroughly studied, the molecular mechanisms regulating the initial formation of the olfactory nerve, the first cranial nerve, remain poorly defined...
  8. ncbi Olfactory ensheathing cells: the primary innate immunocytes in the olfactory pathway to engulf apoptotic olfactory nerve debris
    Zhida Su
    Institute of Neuroscience and Key Laboratory of Molecular Neurobiology of Ministry of Education, Neuroscience Research Center of Changzheng Hospital, Second Military Medical University, Shanghai, China
    Glia 61:490-503. 2013
    ..of the apoptotic ORNs corpses is a fundamental process serving important functions in the regulation of olfactory nerve turnover and regeneration. However, little is known about the underlying mechanisms...
  9. pmc Two GABAergic intraglomerular circuits differentially regulate tonic and phasic presynaptic inhibition of olfactory nerve terminals
    Z Shao
    Program in Neuroscience, University of Maryland School of Medicine, Baltimore, 21201 MD, USA
    J Neurophysiol 101:1988-2001. 2009
    b>Olfactory nerve axons terminate in olfactory bulb glomeruli forming excitatory synapses onto the dendrites of mitral/tufted (M/T) and juxtaglomerular cells, including external tufted (ET) and periglomerular (PG) cells...
  10. ncbi Olfactory ensheathing cells and olfactory nerve fibroblasts maintain continuous open channels for regrowth of olfactory nerve fibres
    Ying Li
    Spinal Repair Unit, Institute of Neurology, University College London, London, United Kingdom
    Glia 52:245-51. 2005
    ..their outer surface, the olfactory ensheathing cell channels have a basal lamina and an outer encirclement of olfactory nerve fibroblasts...
  11. ncbi An updated review of clinical olfaction
    Eric H Holbrook
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, Massachusetts 02114, USA
    Curr Opin Otolaryngol Head Neck Surg 14:23-8. 2006
    ..Disorders of the sense of smell can result through hundreds of different processes, but most commonly occur from upper-respiratory-tract infections, trauma, and chronic rhinosinusitis...
  12. ncbi External tufted cells drive the output of olfactory bulb glomeruli
    Didier De Saint Jan
    Institut National de la Santé et de la Recherche Médicale U603, Universite Paris Descartes, and Centre National de la Recherche Scientifique, UMR 8154, 75006 Paris, France
    J Neurosci 29:2043-52. 2009
    ..Stimulation of the olfactory nerve induced similar population bursts and activated ET cells at a lower threshold than mitral cells, suggesting ..
  13. pmc Cytoskeletal organization of the developing mouse olfactory nerve layer
    Michael R Akins
    Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 494:358-67. 2006
    Olfactory sensory neuron (OSN) axonal extension and targeting occur within the olfactory nerve layer (ONL) of the olfactory bulb (OB)...
  14. ncbi [Researchers of the olfactory nerve function were awarded the Medicine and Physiology Nobel prize]
    Matti Jokelainen
    Suomen Terveystalo Oyj, Hemon lääkärikeskus, Lahti
    Duodecim 120:2865-7. 2004
  15. ncbi Microglial/macrophage cells in mammalian olfactory nerve fascicles
    Laura J Smithson
    Department of Anatomy and Cell Biology, Centre for Neuroscience Studies, Queen s University, Kingston, Ontario, Canada
    J Neurosci Res 88:858-65. 2010
    ..markers Iba1 and annexin A3, and reactivity to bulbectomy (in adult rats), these cells found within the olfactory nerve fascicles of both mammalian species meet several important criteria for their designation as microglia/..
  16. ncbi Thallium transport and the evaluation of olfactory nerve connectivity between the nasal cavity and olfactory bulb
    Yayoi Kinoshita
    Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920, Japan
    Chem Senses 33:73-8. 2008
    Little is known regarding how alkali metal ions are transported in the olfactory nerve following their intranasal administration...
  17. ncbi Abnormalities of axon growth in human olfactory mucosa
    Eric H Holbrook
    Department of Otolaryngology, MA Eye and Ear Infirmary, and Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 115:2144-54. 2005
    ..However, detailed analysis of the subepithelial tissue with specific attention to the fascicles of the olfactory nerve and abnormalities of axonal growth may improve the correlation of histopathology with sensory function.
  18. ncbi Odor detection ability and thallium-201 transport in the olfactory nerve of traumatic olfactory-impaired mice
    Hideaki Shiga
    Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920, Japan
    Chem Senses 33:633-7. 2008
    Although olfactory nerve damage is a contributing factor in the diagnosis of posttraumatic olfactory loss, at present, there are no methods to directly assess injury to these nerves...
  19. ncbi CRBP I and CRABP I localisation during olfactory nerve development
    A L Gustafson
    Department of Pharmaceutical Bioscience, Division of Toxicology, Uppsala Biomedical Centre, Uppsala University, Box 594, 751 24, Uppsala, Sweden
    Brain Res Dev Brain Res 114:121-6. 1999
    ..Our results indicate that RA produced by the CRBP I-expressing 'glia-like' cells may act as a neurotrophic factor for the CRABP I-expressing immature olfactory axons...
  20. ncbi Axonal transport of rubidium and thallium in the olfactory nerve of mice
    Yousuke Kanayama
    School of Health Sciences, Faculty of Medicine, Kanazawa University, Ishikawa, Japan
    Nucl Med Biol 32:505-12. 2005
    ..administration of radioactive (86)Rb(+) and (201)Tl(+) in mice, we observed this direct transport via the olfactory nerve pathway...
  21. ncbi Delayed olfactory nerve regeneration in ApoE-deficient mice
    Britto P Nathan
    Department of Biological Sciences, Eastern Illinois University, 600 Lincoln Avenue, Charleston, IL 61920, USA
    Brain Res 1041:87-94. 2005
    ..OB) following olfactory epithelium (OE) lesion in mice, and hypothesized that apoE may play a vital role in olfactory nerve (ON) regeneration...
  22. ncbi Neurotrophic effect of gonadotropin-releasing hormone on neurite extension and neuronal migration of embryonic gonadotropin-releasing hormone neurons in chick olfactory nerve bundle culture
    Yoh Ichiro Kanaho
    Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
    J Neurosci Res 87:2237-44. 2009
    ..study the role of GnRH in the migratory process of GnRH neurons, we established an in vitro chick embryonic olfactory nerve bundle explant model. Embryonic day 7...
  23. pmc Nicotinic receptor-mediated filtering of mitral cell responses to olfactory nerve inputs involves the α3β4 subtype
    Rinaldo D D'Souza
    Department of Physiology and Biophysics and Neuroscience Program, University of Colorado School of Medicine, Aurora, Colorado 80045, USA
    J Neurosci 32:3261-6. 2012
    ..nAChRs) in regulating the responses of mitral cells (MCs), the output neurons of the olfactory bulb, to olfactory nerve input...
  24. ncbi Intranasal delivery of siRNA to the olfactory bulbs of mice via the olfactory nerve pathway
    Dan B Renner
    Alzheimer s Research Center at Regions Hospital, HealthPartners Research Foundation, 640 Jackson St, St Paul, MN 55101, USA
    Neurosci Lett 513:193-7. 2012
    ..study examined delivery of fluorescently labeled siRNA from the nasal cavity to the olfactory bulbs via the olfactory nerve pathway...
  25. ncbi Olfactory nerve stimulation-evoked mGluR1 slow potentials, oscillations, and calcium signaling in mouse olfactory bulb mitral cells
    Q Yuan
    Laboratory for Neuronal Circuit Dynamics, RIKEN Brain Science Institute, Wako Shi, Saitama, 351 0198, Japan
    J Neurophysiol 95:3097-104. 2006
    ..Here we characterized a slow mGluR1-mediated potential that was evoked by high-frequency (100-Hz) olfactory nerve (ON) stimulation in the presence of NBQX and D-APV, blockers of ionotropic glutamate receptors, and that was ..
  26. ncbi Use of thallium transport to visualize functional olfactory nerve regeneration in vivo
    Hideaki Shiga
    Department of Otorhinolaryngology Head and Neck Surgery, Kanazawa University, Kahokugun, Ishikawa, Japan
    Rhinology 47:460-4. 2009
    To image olfactory nerve regeneration in vivo using a high-resolution gamma cam- era and radiography after nasal administration of thallium-201 (olfacto-scintigraphy).
  27. pmc Olfactory nerve recovery following mild and severe injury and the efficacy of dexamethasone treatment
    Masayoshi Kobayashi
    Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298 0551, USA
    Chem Senses 34:573-80. 2009
    To investigate factors that influence the degree of neural regeneration and recovery, we studied 2 olfactory nerve injury models...
  28. ncbi Evaluation of the olfactory nerve transport function by SPECT-MRI fusion image with nasal thallium-201 administration
    Hideaki Shiga
    Department of Otorhinolaryngology Head and Neck Surgery, Kanazawa Medical University, Kahokugun, Ishikawa, Japan
    Mol Imaging Biol 13:1262-6. 2011
    ..The aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 ((201)Tl) administration...
  29. ncbi Rhinotopy is disrupted during the re-innervation of the olfactory bulb that follows transection of the olfactory nerve
    M D Christensen
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Chem Senses 26:359-69. 2001
    Re-innervation of the olfactory bulb was investigated after transection of the olfactory nerve using monoclonal antibody RB-8 to assess whether rhinotopy of the primary olfactory projection is restored...
  30. ncbi Usefulness and feasibility of psychophysical and electrophysiological olfactory testing in the rhinology clinic
    P Rombaux
    Department of Otorhinolaryngology, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Brussels, Belgium
    Rhinology 47:28-35. 2009
    ..The purpose of this study is to assess the usefulness and feasibility of these diagnostic tools in the rhinology clinic and to correlate these results to the olfactory disorder aetiology...
  31. pmc Theta bursts in the olfactory nerve paired with beta-adrenoceptor activation induce calcium elevation in mitral cells: a mechanism for odor preference learning in the neonate rat
    Qi Yuan
    University of California at San Diego, La Jolla, California 92093, USA
    Learn Mem 16:676-81. 2009
    ..Here a mechanism for enhanced mitral cell signaling is described. Theta bursts in the olfactory nerve (ON) produce long-term potentiation (LTP) of glomerular excitatory postsynaptic potentials (EPSPs) and of ..
  32. ncbi Signal-to-noise ratio of chemosensory event-related potentials
    Sanne Boesveldt
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Clin Neurophysiol 118:690-5. 2007
    ..We investigated the influence of the number of stimuli on signal-to-noise (S/N) ratio of CSERP...
  33. pmc Axon fasciculation in the developing olfactory nerve
    Alexandra M Miller
    Department of Neurosurgery, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neural Dev 5:20. 2010
    ..While regional segregation occurs in the mesenchyme, the final convergence of OR-specific subpopulations does not occur until the axons reach the inner nerve layer of the OB...
  34. pmc Calcium signaling in mitral cell dendrites of olfactory bulbs of neonatal rats and mice during olfactory nerve Stimulation and beta-adrenoceptor activation
    Qi Yuan
    Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, Wako Shi, Saitama, 351 0198, Japan
    Learn Mem 11:406-11. 2004
    Synapses formed by the olfactory nerve (ON) provide the source of excitatory synaptic input onto mitral cells (MC) in the olfactory bulb...
  35. pmc Olfactory system involvement in natural scrapie disease
    Cristiano Corona
    CEA, Italian Reference Laboratory for TSE, Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d Aosta, Turin, Italy
    J Virol 83:3657-67. 2009
    ..infection by prions following intracerebral challenge suggested a potential centrifugal spread along the olfactory nerve fibers of the pathological prion protein (PrP(Sc))...
  36. ncbi The influence of training on chemosensory event-related potentials and interactions between the olfactory and trigeminal systems
    Andrew Livermore
    School of Social Sciences and Liberal Studies, Charles Sturt University, Bathurst, NSW 2790, Australia
    Chem Senses 29:41-51. 2004
    ..This was supported by a significant decrease of amplitudes of the event-related potentials at frontal recording sites following training with the test odor only..
  37. ncbi BIG-2 mediates olfactory axon convergence to target glomeruli
    Tomomi Kaneko-Goto
    Laboratory for Neurobiology of Synapse, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    Neuron 57:834-46. 2008
    ..These results suggest that BIG-2 is one of the axon guidance molecules crucial for the formation and maintenance of functional odor map in the olfactory bulb...
  38. pmc Transplanted olfactory ensheathing cells remyelinate and enhance axonal conduction in the demyelinated dorsal columns of the rat spinal cord
    T Imaizumi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 18:6176-85. 1998
    ..These data support the conclusion that transplantation of neonatal OECs results in quantitatively extensive and functional remyelination of demyelinated dorsal column axons...
  39. pmc Activation of the Wnt/beta-catenin signaling reporter in developing mouse olfactory nerve layer marks a specialized subgroup of olfactory ensheathing cells
    Ya Zhou Wang
    Department of Cell Biology and Human Anatomy, University of California, Davis, School of Medicine, and Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, California 95817, USA
    Dev Dyn 237:3157-68. 2008
    ..During early postnatal development, betagal+ cells were located in the inner olfactory nerve layer (ONLi) and co-labeled with olfactory ensheathing cell (OEC) markers S100beta and NPY but not with ..
  40. pmc Olfactory nerve--a novel invasion route of Neisseria meningitidis to reach the meninges
    Hong Sjölinder
    Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e14034. 2010
    ..Taken together, N. meningitidis is able to pass directly from nasopharynx to meninges through the olfactory nerve system. This study enhances our understanding how N. meningitidis invades the meninges...
  41. ncbi Role of interleukin-15 in the development of mouse olfactory nerve
    Tsuyoshi Umehara
    Department of Otorhinolaryngology, Faculty of Medicine, Shimane University, Izumo, Japan
    Congenit Anom (Kyoto) 49:253-7. 2009
    ..Adult IL-15R alpha knockout mice had fewer mature olfactory neurons and proliferating cells than wild-type. Our results suggest that IL-15 plays an important role in regulating cell proliferation in olfactory neurogenesis...
  42. ncbi Glutamate and synaptic plasticity at mammalian primary olfactory synapses
    M Ennis
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore 21201, USA
    Ann N Y Acad Sci 855:457-66. 1998
    Glutamate is the transmitter at synapses from the olfactory nerve (ON) to mitral (Mi)/tufted cells, but very little is known about the functional properties of this synapse...
  43. pmc Novel gene expressed in nasal region influences outgrowth of olfactory axons and migration of luteinizing hormone-releasing hormone (LHRH) neurons
    P R Kramer
    Cellular and Developmental Neurobiology Section, National Institute of Neurological Disorders and Stroke NINDS, National Institutes of Health NIH, Bethesda, Maryland 20892, USA
    Genes Dev 14:1824-34. 2000
    ..These results demonstrate that NELF plays a role as a common guidance molecule for olfactory axon projections and subsequently, either directly or indirectly, in the neurophilic migration of LHRH cells...
  44. ncbi Sall1 regulates mitral cell development and olfactory nerve extension in the developing olfactory bulb
    Susan J Harrison
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Cereb Cortex 18:1604-17. 2008
    ..In addition, the olfactory nerve failed to extend past the ventral-medial region of the OB in Sall1-deficient animals...
  45. ncbi Microsurgical anatomic features of the olfactory nerve: relevance to olfaction preservation in the pterional approach
    Salvatore Cardali
    Neurosurgical Clinic, Department of Neurosciences, University of Messina Medical School, Messina, Italy
    Neurosurgery 57:17-21; discussion 17-21. 2005
    ....
  46. pmc Intercellular interactions in the mammalian olfactory nerve
    Karen J Blinder
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Comp Neurol 466:230-9. 2003
    ..We recently demonstrated ephaptic interactions between these axons in the olfactory nerve layer, the layer of the olfactory bulb in which the axon fascicles interweave and rearrange extensively...
  47. ncbi Olfactory bulb DA receptors may be located on terminals of the olfactory nerve
    W T Nickell
    Department of Anatomy, University of Cincinnati College of Medicine, OH 45267
    Neuroreport 2:9-12. 1991
    ..3H]SCH23390 was slightly above background and was distributed through all layers of the bulb except the olfactory nerve layer...
  48. pmc Olfactory nerve-evoked, metabotropic glutamate receptor-mediated synaptic responses in rat olfactory bulb mitral cells
    Matthew Ennis
    Department of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    J Neurophysiol 95:2233-41. 2006
    ..on the apical dendrites of olfactory bulb mitral cells and thus may be activated by glutamate released from olfactory nerve (ON) terminals. Previous studies have shown that mGluR1 agonists directly excite mitral cells...
  49. pmc Transplantation of human olfactory ensheathing cells elicits remyelination of demyelinated rat spinal cord
    T Kato
    Department of Neurosurgery, Sapporo Medical University School of Medicine, Sapporo, Japan
    Glia 30:209-18. 2000
    ..These results provide evidence that adult human OECs are able to produce Schwann cell-like myelin sheaths around demyelinated axons in the adult mammalian CNS in vivo...
  50. ncbi Expression of the dm-20 isoform of the plp gene in olfactory nerve ensheathing cells: evidence from developmental studies
    P J Dickinson
    Applied Neurobiology Group, University of Glasgow Veterinary School, Bearsden, UK
    J Neurocytol 26:181-9. 1997
    ..plp gene activity was present in the non-myelinated olfactory nerve layer of the bulb from E14 through to adult ages...
  51. ncbi Expression of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in the developing olfactory bulb and subventricular zone rostral extension
    Silvana S Gomes
    Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil
    J Neurosci Res 73:471-80. 2003
    ..They also raise the possibility that a minor fraction of OB oligodendrocytes might derive from the SVZ-RE...
  52. ncbi Interplay between local GABAergic interneurons and relay neurons generates gamma oscillations in the rat olfactory bulb
    Samuel Lagier
    Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 75724 Paris, France
    J Neurosci 24:4382-92. 2004
    ..We showed that a single and brief electrical stimulation of olfactory nerve elicited LFP oscillations in the mitral cell body layer lasting >1 sec...
  53. ncbi Olfactory nerve stimulation-induced calcium signaling in the mitral cell distal dendritic tuft
    Q Yuan
    Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, Saitama, Japan
    J Neurophysiol 95:2417-26. 2006
    Olfactory receptor neuron axons form the olfactory nerve (ON) and project to the glomerular layer of the olfactory bulb, where they form excitatory synapses with terminal arborizations of the mitral cell (MC) tufted primary dendrite...
  54. ncbi Structure of intraglomerular dendritic tufts of mitral cells and their contacts with olfactory nerve terminals and calbindin-immunoreactive type 2 periglomerular neurons
    K Kosaka
    Department of Anatomy and Neurobiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Comp Neurol 440:219-35. 2001
    ..In particular, the relationships of BDA-labeled tufts with olfactory nerve (ON) terminals and processes of calbindin D-28K-immunoreactive (CB-IR) cells were investigated with confocal ..
  55. ncbi The relationship of particle size to olfactory nerve uptake of a non-soluble form of manganese into brain
    Laurence D Fechter
    Department of Occupational and Environmental Health and Pharmaceutical Sciences, College of Pharmacy, Oklahoma Center for Toxicology, University of Oklahoma Health Sciences Center, Oklahoma City 73190, USA
    Neurotoxicology 23:177-83. 2002
    ..Recent data suggest that a third route of exposure, transport by the olfactory nerve directly to the brain, might have importance in toxicology since such a route would bypass liver uptake and ..
  56. ncbi Expression of netrin-1 and netrin-1 receptor, DCC, in the rat olfactory nerve pathway during development and axonal regeneration
    L Astic
    Laboratoire de Neurosciences et Systèmes Sensoriels, CNRS UMR 5020, Université VClaude Bernard Lyon 1, France
    Neuroscience 109:643-56. 2002
    ..This expression was transient since from embryonic day 16 onwards, DCC was no longer detected along the olfactory nerve path...
  57. pmc Ultrastructural localization of connexins (Cx36, Cx43, Cx45), glutamate receptors and aquaporin-4 in rodent olfactory mucosa, olfactory nerve and olfactory bulb
    John E Rash
    Department of Biomedical Sciences, Colorado State University, Fort Collins, 80523, USA
    J Neurocytol 34:307-41. 2005
    ..immunofluorescence microscopy to examine Cx36, Cx43 and Cx45 protein in gap junctions in olfactory mucosa, olfactory nerve and OB in adult rats and mice and early postnatal rats...
  58. ncbi Sensory neuron signaling to the brain: properties of transmitter release from olfactory nerve terminals
    Gabe J Murphy
    Neuroscience Graduate Program and Department of Neuroscience, University of California, San Diego School of Medicine, La Jolla, California 92093 0608, USA
    J Neurosci 24:3023-30. 2004
    ..firing of ORNs is transmitted to the brain, we examined the properties of glutamate release from olfactory nerve (ON) terminals in slices of the rat olfactory bulb...
  59. ncbi Semaphorin 3A is required for guidance of olfactory axons in mice
    G A Schwarting
    The Shriver Center, Waltham, Massachusetts 02452, USA
    J Neurosci 20:7691-7. 2000
    ..These observations indicate that Sema3A expression by ensheathing cells plays an important role in guiding olfactory axons into specific compartments of the OB...
  60. ncbi Disrupted compartmental organization of axons and dendrites within olfactory glomeruli of mice deficient in the olfactory cell adhesion molecule, OCAM
    Andreas Walz
    The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Mol Cell Neurosci 32:1-14. 2006
    ..Instead, OCAM is required for establishing or maintaining the compartmental organization and the segregation of axodendritic and dendrodendritic synapses within glomeruli...
  61. ncbi EphB2 and two of its ligands have dynamic protein expression patterns in the developing olfactory system
    J A St John
    Neurodevelopment Laboratory, Department of Anatomical Sciences, The University of Queensland, 4072, Brisbane, Australia
    Brain Res Dev Brain Res 126:43-56. 2001
    ....
  62. ncbi Reciprocal interactions between olfactory receptor axons and olfactory nerve glia cultured from the developing moth Manduca sexta
    Eric S Tucker
    Department of Cell Biology and Anatomy, University of Arizona, PO Box 245044, Tucson, AZ 85724 5044, USA
    Dev Biol 260:9-30. 2003
    ....
  63. ncbi Lymphatic vessels gain access to cerebrospinal fluid through unique association with olfactory nerves
    Andrei Zakharov
    Neuroscience Research, Department of Laboratory Medicine and Pathobiology, Sunnybrook and Women s College Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada
    Lymphat Res Biol 2:139-46. 2004
    ..Especially important is CSF transport through the cribriform plate in association with the olfactory nerves. This study examined the anatomical connections that link the CSF and extracranial lymphatics at the base of the brain...
  64. ncbi Axon behavior in the olfactory nerve reflects the involvement of catenin-cadherin mediated adhesion
    Michael R Akins
    Interdepartmental Neuroscience Graduate Program, Yale University School of Medicine, New Haven, Connecticut 06520 8082, USA
    J Comp Neurol 499:979-89. 2006
    ..We demonstrate that axons remain restricted to the outer olfactory nerve layer (ONLo) until they are proximal to their target glomeruli, where they enter the inner ONL (ONLi), ..
  65. ncbi Imaging the olfactory tract (cranial nerve #1)
    Thierry P Duprez
    Department of Radiology and Medical Imaging, Universite Catholique de Louvain, Cliniques Universitaires Saint Luc, Avenue Hippocrate, 10, 1200 Brussels, Belgium
    Eur J Radiol 74:288-98. 2010
    ..Techniques for collecting quantitative data on olfactory bulb volume and on olfactory sulcus depth are described. At last, insights into functional imaging of olfactory sense are shown...
  66. ncbi [Axonal mRNAs: from histochemical visualization to functional analyses]
    Alain Trembleau
    Equipe Avenir INSERM Développement et Plasticité des Réseaux Neuronaux, CNRS UMR 7102, Universite Pierre et Marie Curie Paris 6, Boîte 12, 9 Quai St Bernard, 75005 Paris, France
    J Soc Biol 203:65-73. 2009
    ..The aim of this paper is to illustrate, taking mainly the mouse olfactory system as an example, conceptual and methodological approaches developed in particular in my group, that aim at identifying the function of these axonal mRNAs...
  67. ncbi Target tissue influences the peripheral trajectory of mouse primary sensory olfactory axons
    Melonie J Storan
    Department of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
    J Neurobiol 61:175-88. 2004
    ....
  68. ncbi Defining the role of olfactory ensheathing cells in facilitating axon remyelination following damage to the spinal cord
    J Gordon Boyd
    Department of Anatomy and Cell Biology, Queen s University, Room 926, Botterell Hall, Kingston, ON, Canada K7L 3N6
    FASEB J 19:694-703. 2005
    ..Together with Schwann cells, OECs create a 3-dimensional matrix that provides a permissive microenvironment for successful axon regeneration in the adult mammalian central nervous system...
  69. pmc LacZ-expressing olfactory ensheathing cells do not associate with myelinated axons after implantation into the compressed spinal cord
    J G Boyd
    Department of Anatomy and Cell Biology, Queen s University, Kingston, ON, Canada K7L 3N6
    Proc Natl Acad Sci U S A 101:2162-6. 2004
    ..These observations suggest that the role of OECs as the primary mediators of the beneficial effects on axon growth, myelination, and functional recovery after spinal cord injury may require re-evaluation...
  70. ncbi Promoting central nervous system regeneration: lessons from cranial nerve I
    Marc J Ruitenberg
    Experimental and Regenerative Neuroscience EaRN, School of Anatomy and Human Biology M309, The University of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia
    Restor Neurol Neurosci 26:183-96. 2008
    The olfactory nerve differs from cranial nerves III-XII in that it contains a specialised type of glial cell, called 'olfactory ensheathing cell' (OEC), rather than Schwann cells...
  71. pmc Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse
    Thomas Bozza
    The Rockefeller University, New York, NY 10065, USA
    Neuron 61:220-33. 2009
    ..Axons from the two OSN types segregate already within the olfactory nerve and form distinct domains of glomeruli in the OB...
  72. ncbi Expression of EphA5 during development of the olfactory nerve pathway in rat
    J A St John
    Department of Anatomical Sciences, University of Queensland, Brisbane, Australia
    J Comp Neurol 416:540-50. 2000
    ..The mechanisms responsible for persistent growth and guidance of primary olfactory axons along the olfactory nerve are unknown...
  73. ncbi Evaluation of olfactory nerve function after aneurysmal subarachnoid hemorrhage and clip occlusion
    Joost De Vries
    Departments of Neurosurgery, Radboud University, Nijmegen, The Netherlands
    J Neurosurg 107:1126-9. 2007
    In this study, the olfactory nerve function (ONF) in patients with an aneurysmal subarachnoid hemorrhage (SAH) who underwent neurosurgical clip occlusion for intracranial aneurysm was assessed pre- and postoperatively.
  74. ncbi The neural representation of odor is modulated by the presence of a trigeminal stimulus during odor encoding
    M Bensafi
    Laboratoire Neurosciences and Systèmes Sensoriels, CNRS UMR5020, Universite Claude Bernard Lyon 1, 50, Avenue Tony Garnier, 69366 Lyon Cedex 07, France
    Clin Neurophysiol 118:696-701. 2007
    ..The present study set out to examine whether the presence of a pure trigeminal stimulus during odor encoding may modulate odor perception at both behavioral and cortical levels...
  75. pmc The olfactory nerve has a role in the body temperature and brain cytokine responses to influenza virus
    Victor H Leyva-Grado
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, WA 99164 6520, USA
    Brain Behav Immun 24:281-8. 2010
    ..To determine whether signals from the olfactory nerve influence the unfolding of the acute phase response (APR), we surgically transected the olfactory nerve in ..
  76. ncbi Evidence that olfactory sensitivities to calcium and sodium are mediated by different mechanisms in the goldfish Carassius auratus
    Peter C Hubbard
    Centro de Ciencias do Mar, Universidade do Algarve, Campus de Gambelas, 8005 139 Faro, Portugal
    Neurosci Lett 414:90-3. 2007
    ..However, there seems to be a degree of overlap between the two mechanisms. The exact mechanisms involved, and their biological roles, remain to be established...
  77. ncbi Effect of ginkgo biloba and dexamethasone in the treatment of 3-methylindole-induced anosmia mouse model
    Chul Hee Lee
    Department of Otorhinolaryngology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea
    Am J Rhinol 22:292-6. 2008
    ..This study is designed to identify the effect of ginkgo biloba, an antioxidant that acts as a free radical scavenger, in the treatment of olfactory injury aggravated by dexamethasone...
  78. ncbi External tufted cells: a major excitatory element that coordinates glomerular activity
    Abdallah Hayar
    Department of Anatomy and Neurobiology, Program in Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 24:6676-85. 2004
    ..ET cells spontaneously fired rhythmic spike bursts in the theta frequency range and received monosynaptic olfactory nerve (ON) input. In contrast, all SA and most PG cells lacked monosynaptic ON input...
  79. ncbi Theoretical consideration of olfactory axon projection with an activity-dependent neural network model
    Hirokazu Tozaki
    Division of Brain Function, National Institute of Genetics, Graduate University for Advanced Studies, Mishima 411 8540, Japan
    Mol Cell Neurosci 26:503-17. 2004
    ..Taken together, the activity-dependent targeting of olfactory axons seems to be a simple probable mechanism that can provide a unified explanation of glomerular formation...
  80. ncbi [From nose to brain : a subtle connection]
    Aurélie Mouret
    Med Sci (Paris) 23:252-5. 2007
  81. ncbi 3D atlas describing the ontogenic evolution of the primary olfactory projections in the olfactory bulb of Xenopus laevis
    Arnaud Gaudin
    Centre des Sciences du Goût Unité Mixte de Recherche 5170 Centre National de la Recherche Scientifique Université de Bourgogne Institut National de la Recherche Agronomique, F 21000 Dijon, France
    J Comp Neurol 489:403-24. 2005
    ..We generated a 3D atlas at several stages which are representative of the reorganization process. This will be a useful tool for future studies of development and function...
  82. ncbi Olfactory and sensory attributes of the nose
    Bozena B Wrobel
    Department of Otolaryngology Head and Neck Surgery, University of Southern California, 1520 San Pablo Street, Suite 4600, Los Angeles, CA 90033, USA
    Otolaryngol Clin North Am 38:1163-70. 2005
    ..Healthy olfactory mucosa allows for appreciation of pleasant aromas and food flavors. The olfactory nerve, in concert with the trigeminal nerve, serves as a main interpreter and modulator of chemosensory information...
  83. ncbi The shape of the olfactory bulb influences axon targeting
    Fatemeh Chehrehasa
    Brain Growth and Regeneration Lab, Discipline of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
    Brain Res 1169:17-23. 2007
    ..To begin to understand the role of the olfactory bulb in the formation of the olfactory nerve pathway, we developed a model whereby the gross shape of the bulb in the P2-IRES-tau-LacZ line of mice was ..
  84. ncbi Early upregulation in nasal epithelium and strong expression in olfactory bulb glomeruli suggest a role for Aquaporin-4 in olfaction
    Jan Gunnar Sørbø
    Center for Molecular Biology and Neuroscience CMBN, University of Oslo, Norway
    FEBS Lett 581:4884-90. 2007
    ..However, in the nasal epithelium AQP4 is upregulated as early as in the brain. Furthermore, AQP4 is strongly expressed in the glomerulus, the synaptic unit of the olfactory bulb, suggesting a role for AQP4 in olfactory function...
  85. pmc Activation of postsynaptic GABAB receptors modulates the bursting pattern and synaptic activity of olfactory bulb juxtaglomerular neurons
    Nikolay Karpuk
    Deptepartment of Neurobiology and Developmental Sciences, Center for Translational Neuroscience, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Neurophysiol 99:308-19. 2008
    ..that gamma-aminobutyric acid (GABA) released from PG neurons presynaptically inhibits glutamate release from olfactory nerve terminals via activation of GABA(B) receptors (GABA(B)-Rs)...
  86. ncbi Optical mapping of spatiotemporal emergence of functional synaptic connections in the embryonic chick olfactory pathway
    K Sato
    Department of Physiology, Tokyo Medical and Dental University, Graduate School and Faculty of Medicine, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Neuroscience 144:1334-46. 2007
    ..we elucidate the functional maturation of forebrain circuits by investigating neural networks related to the olfactory nerve (N. I) of chicken embryo. In the isolated N...
  87. ncbi Multipotent stem and progenitor cells of the olfactory epithelium
    I V Viktorov
    V P Serbsky State Research Center of Social and Forensic Psychiatry, Moscow
    Bull Exp Biol Med 142:495-502. 2006
    ....
  88. ncbi Signal processing with temporal sequences in olfactory systems
    Andrzej G Lozowski
    Department of Electrical and Computer Engineering, Southern Illinois University, Edwardsville, IL 62026, USA
    IEEE Trans Neural Netw 15:1268-75. 2004
    ..Ultimately, such pattern matching results in ability to recognize odors and offer a hypothetic model for signal processing occurring in the primary stage of the olfactory system...
  89. ncbi Mechanical obstruction of the olfactory cleft reveals differences between orthonasal and retronasal olfactory functions
    Oliver Pfaar
    Department of Otorhinolaryngology, University of Dresden Medical School, Fetscherstrasse 74, D 01307 Dresden, Germany
    Chem Senses 31:27-31. 2006
    ..This might become a valuable model of hyposmia for future investigations...
  90. ncbi Development of wiring specificity in the olfactory system
    Takaki Komiyama
    Howard Hughes Medical Institute, Department of Biological Sciences and Neurosciences Program, Stanford University, Stanford, CA, 94305, USA
    Curr Opin Neurobiol 16:67-73. 2006
    ....
  91. ncbi [Recent progress in diagnosis of otorhinolaryngologic diseases: brain map--basic studies on dysosmia related olfactory sense]
    Kensaku Mori
    Nihon Jibiinkoka Gakkai Kaiho 108:1067-70. 2005
  92. ncbi Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system
    Alexandra Veyrac
    UMR 5020, Neurosciences et Systemes Sensoriels, CNRS Universite Claude Bernard Lyon 1, 50 avenue Tony Garnier, F 69366 Lyon Cedex 07, France
    Eur J Neurosci 21:2635-48. 2005
    ....
  93. ncbi Retinoic acid receptor-dependent survival of olfactory sensory neurons in postnatal and adult mice
    Maria Hägglund
    Department of Molecular Biology, Umea University, SE901 87 Umea, Sweden
    J Neurosci 26:3281-91. 2006
    ..Collectively, the results provide evidence for a role of locally regulated retinoid metabolism in neuroprotection and in determining population size of neurons at a late stage of neural circuit formation...
  94. ncbi Formation of glomerular maps in the olfactory system
    Jörg Strotmann
    University of Hohenheim, Institute of Physiology, Garbenstrasse 30, D 70599 Stuttgart, Germany
    Semin Cell Dev Biol 17:402-10. 2006
    ..While the initial process of glomerulization requires mainly molecular determinants, activity-dependent processes lead to a refinement of glomerular organization...
  95. ncbi Temporal profiling of gene expression during neurogenesis and remodeling in the olfactory epithelium at short intervals after target ablation
    Thomas V Getchell
    Department of Physiology, University of Kentucky, Lexington, 40536 0230, USA
    J Neurosci Res 80:309-29. 2005
    ..These studies are an important first step in defining early time-dependent changes in gene expression after target ablation that lead to neurogenesis in the olfactory sensory epithelium...
  96. ncbi Odor-driven activity in the olfactory cortex of an in vitro isolated guinea pig whole brain with olfactory epithelium
    Takahiro Ishikawa
    Division of Systems Neuroscience, Tohoku University Graduate School of Life Sciences, 2 1 1 Katahira, Aoba ku, Sendai 980 8577, Japan
    J Neurophysiol 97:670-9. 2007
    ..This study provides the basis for clarifying the sequence of neural activities underlying odor information processing in the brain in vitro following natural olfactory stimulation...
  97. ncbi Imaging of olfaction and gustation
    Ivanka Savic-Berglund
    Karolinska Institutet Centre of Gender Related Medicine, Stockholm, Sweden
    Nutr Rev 62:S205-7; discussion S224-41. 2004
    ..More irritating, burning odors (e.g., acetone) project via the trigeminal rather than the olfactory nerve and induce changes in the brain stem and the cortex...
  98. ncbi Implantation of a scaffold following bulbectomy induces laminar organization of regenerating olfactory axons
    Fatemeh Chehrehasa
    Brain Growth and Regeneration Lab, Discipline of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane 4072, Australia
    Brain Res 1119:58-64. 2006
    Primary olfactory axons expressing different odorant receptors are interspersed within the olfactory nerve. However, upon reaching the outer nerve fiber layer of the olfactory bulb they defasciculate, sort out, and refasciculate prior to ..
  99. ncbi Characterization of somatostatin- and cholecystokinin-immunoreactive periglomerular cells in the rat olfactory bulb
    María Gutierrez-Mecinas
    Departamento de Biologia Celular, Facultad de Ciencias Biologicas, Universidad de Valencia, E 46100 Burjasot, Spain
    J Comp Neurol 489:467-79. 2005
    ..of the olfactory bulb (OB) that modulate the first synaptic relay of the olfactory information from the olfactory nerve to the dendrites of the bulbar principal cells...
  100. ncbi The alteration of odor-induced c-Fos immunoreactivity in the rat olfactory bulb after olfactory nerve transection
    Masahiro Kawamoto
    Department of Otolaryngology and Sensory Organ Surgery E8, Osaka University School of Medicine, 2 2 Yamadaoka, Suita City, Osaka 5650871, Japan
    J Neurol 250:51-4. 2003
    We used the rats in which one olfactory nerve had been transected and observed the odor (Propionic acid) -induced c-Fos immunoreactivity in the bulb at different times (2, 4, 8 weeks) after nerve transection...
  101. ncbi The Dlx5 homeodomain gene is essential for olfactory development and connectivity in the mouse
    Giovanni Levi
    Laboratoire de Physiologie Général et Comparée, CNRS, UMR 8572, Museum national d histoire naturelle, Paris, France
    Mol Cell Neurosci 22:530-43. 2003
    ..Thus, the absence of Dlx5 in the OB does not per se prevent ORN axon ingrowth. In conclusion, Dlx5 plays major roles in the connectivity of ORN axons and in the differentiation of OB interneurons...

Research Grants63

  1. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2005
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  2. Cognitive modulation of primary sensory processing in olfactory receptor neurons
    John P McGann; Fiscal Year: 2013
    ..odor without the tone evokes much less presynaptic calcium influx and less neurotransmitter release from the olfactory nerve than when the odor follows the cue...
  3. Mechanisms of prion transport
    Richard A Bessen; Fiscal Year: 2013
    ..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion ..
  4. fMRI Correlates of Olfactory and Visual Cues in Tobacco Smoking
    STEVEN BRADLEY LOWEN; Fiscal Year: 2010
    ..The use of new brain mapping tools will allow such relationships to be identified. ..
  5. Acitivity-Dependent Plasticity of Sensory Synapses in the Olfactory Bulb
    Hong Wei Dong; Fiscal Year: 2009
    ..My new preliminary data demonstrate that brief, high frequency bursts (theta-burst stimulation, TBS) of olfactory nerve (ON) stimulation produce robust, long-term changes in the strength of neurotransmission at ON synapses in the ..
  6. The Olfactory Nerve
    Charles A Greer; Fiscal Year: 2013
    ..What is the relationship of individual axons to the olfactory ensheathing cells along the course of the olfactory nerve and olfactory nerve layer? How are growth cones distributed and organized in the fascicles both during early ..
  7. Olfactory Support Cells
    Timothy S McClintock; Fiscal Year: 2010
    ..chemicals, in part by generating a favorable microenvironment and retaining the ability to replace damaged olfactory nerve cells even as aging occurs...
  8. Biophysics of forward and lateral connections in a genetically-tractable circuit
    Hokto Kazama; Fiscal Year: 2010
    ..transmission will be characterized by recording from identified PNs while electrically stimulating the olfactory nerve. Interglomerular interactions among PNs and LNs will be characterized using genetically encoded "triggers" to ..
  9. Enhancement of olfactory neuron survival and targeting via odorant exposure
    Eric H Holbrook; Fiscal Year: 2010
    ..tested through three specific aims all utilizing the mouse model of recovery from methyl bromide exposure or olfactory nerve transection...
  10. Extracellular Matrix Mediates Axonal Integrity Following Brain Injury
    Linda L Phillips; Fiscal Year: 2013
    ..TBI : 1) to document OPN/MMP2,9 during axonal injury within fiber environments enriched in unmyelinated (ON, olfactory nerve) and myelinated fibers (IC, internal capsule), and determine if OPN KO and MMP9KO alters these changes, 2) to ..
  11. Depth-resolved Optical Imaging of Neural Action Potentials
    Taner Akkin; Fiscal Year: 2013
    ..for depth-resolved imaging of neural activity in various preparations including squid giant axon, pike olfactory nerve, and salamander and mouse retinas...
  12. A Role for Migrating Olfactory Placode Cells in Olfactory Nerve Development
    Alexandra Miller; Fiscal Year: 2010
    ..Specifically, this proposal focuses on the development of the primary olfactory nerve pathway (ONP), which connects the olfactory sensory neurons (OSNs), which reside in the OE, to the olfactory ..
  13. Relating Synaptic Plasticity to Changes in Odor Representation and Perception
    John P McGann; Fiscal Year: 2012
    ..that the olfactory system exhibits rapid feedback presynaptic inhibition of transmitter release from the olfactory nerve. I hypothesize that the rapid plasticity of this circuit provides adaptive gain control for the primary ..
  14. Neuron Glial Interactions
    Charles A Greer; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The mechanisms influencing the capacity of the olfactory nerve for ongoing replacement of olfactory sensory neuron axons is not well understood...
  15. DEVELOPMENT AND MIGRATION OF LHRH NEURONS
    Robert Norgren; Fiscal Year: 1999
    ..Recent studies have demonstrated that X-linked Kallmann's disease is due to a failure of the olfactory nerve to enter the telencephalon and LHRH neurons to migrate into the brain...
  16. LOCUS COERULEUS MODULATION OF OLFACTORY NETWORK FUNCTION
    Michael Shipley; Fiscal Year: 2005
    ..in vivo has a dramatic 'modulatory' action increasing mitral cells (MCs) responses to weak but not strong olfactory nerve (ON) shocks...
  17. NEUROTROPHINS IN OLFACTORY DEVELOPMENT
    Kathleen Guthrie; Fiscal Year: 2002
    ..mRNAs are expressed by olfactory sensory neurons and if neurotrophin proteins are localized within olfactory nerve projections...
  18. NUTRITIONAL MODULATION OF OLFACTORY SYSTEM INTEGRITY
    NANCY RAWSON; Fiscal Year: 1999
    ..or IGF-I mRNA, or their receptor proteins or mRNAs in the olfactory bulb and epithelium change in response to olfactory nerve section; (4) Determine whether altered nutritional status (PR and StD) influences repair of the olfactory ..
  19. HEAT SHOCK PROTEINS IN THE OLFACTORY EPITHELIUM
    VIRGINIA CARR; Fiscal Year: 1993
    ..and physiological stresses (olfactory bulbectomy and bulbectomy-induced synaptic target deprivation, olfactory nerve axotomy neonatal naris closure, decreased O2, and hyperthermia)...
  20. MODEL TO STUDY THE PHYSIOLOGY OF SMALL NERVE FIBERS
    GEORGE KRACKE; Fiscal Year: 1993
    ..The garfish olfactory nerve is a unique experimental model system in which to study the physiology of C fibers...
  21. ODOR RESPONSES AND ANATOMY OF OLFACTORY BULB NEURONS
    Kathryn Hamilton; Fiscal Year: 1991
    ..except in one pattern evoked by high odor concentration, unlike in responses to electrical stimulation of the olfactory nerve or tract. In the responses to electrical stimulation, excitation always preceded inhibition...
  22. COMPLEX LIPID METABOLISM IN THE AXON
    Robert Gould; Fiscal Year: 1991
    ..By studying the lipid enzymes from axoplasm (squid giant axons) and axolemma (frog olfactory nerve) in a comparative way, we can begin to understand how activities of the key axonal enzymes might be regulated ..
  23. Relating Synaptic Plasticity to Changes in Odor Representation and Perception
    JOHN MCGANN; Fiscal Year: 2009
    ..that the olfactory system exhibits rapid feedback presynaptic inhibition of transmitter release from the olfactory nerve. I hypothesize that the rapid plasticity of this circuit provides adaptive gain control for the primary ..
  24. Cyclic nucleotide modulation of olfactory sensory input
    GABE MURPHY; Fiscal Year: 2003
    ..To do this, neurons that receive synaptic input from the olfactory nerve will be whole cell patch clamped...
  25. MECHANISMS OF AXONAL PLASTICITY FOLLOWING INJURY
    CHARLES GREER; Fiscal Year: 2002
    ..the hypothesis that specific subpopulations of glial cells, in particular the ensheathing cells of the olfactory nerve, may provide an optimal substrate...
  26. CYTOSKELETON OF THE OLFACTORY NEURON
    Paul Burton; Fiscal Year: 1990
    ..The substructure of isolated neurofilaments and neurofilaments in situ will be studied. Homogenates of olfactory nerve will be examined by SDS disc and slab gel electrophoresis to characterize the kinds of proteins present, ..
  27. Interaction of ApoE with Estrogen in the Olfactory System
    Britto Nathan; Fiscal Year: 2008
    ..This hypothesis is based on the following observations. First, olfactory nerve regeneration was severely delayed in apoE-gene knockout (KO) mice as compared to wild-type (WT) litermates...
  28. DEAFFERENTATION OF THE OLFACTORY BULB IN ADULT ZEBRAFISH
    Christine Byrd; Fiscal Year: 2004
    ..2: Does removal of only odor-induced activity cause the same changes in the olfactory bulb as physical deafferentation? Specific Aim 3: Does transection of the olfactory nerve induce the same effect as ablation of the olfactory organ?
  29. Strategies for Restoring Olfactory Neurogenesis
    JAMES SCHWOB; Fiscal Year: 2004
    ..abstract_text> ..
  30. Gene Expression Profiling of Adult Olfactory Stem and Progenitor Cells
    JAMES SCHWOB; Fiscal Year: 2008
    ..adult stem cells resemble in both molecular and functional terms, give rise to the specialized glia of the olfactory nerve, which may promote functional recovery after spinal cord injury...
  31. DEVELOPMENT OF THE PRIMARY OLFACTORY PROJECTION
    JAMES SCHWOB; Fiscal Year: 2005
    ..Attempts to foster recovery in the clinical population require an understanding in depth of the inherent limits and capacities for regeneration. ..
  32. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..These sensory axons create a pathway, the olfactory nerve, connecting the peripheral and central nervous system...
  33. Mechanisms of prion transport
    RICHARD BESSEN; Fiscal Year: 2008
    ..These studies can determine the role of the olfactory nerve in centrifugal prion spread to the nasal mucosa where agent shedding is a potential route of prion ..
  34. Development of gonadotropin releasing hormone cells
    KATHLEEN WHITLOCK; Fiscal Year: 2009
    ..is likely only a consequence of the disruption in the migration of GnRH cells to the hypothalamus along the olfactory nerve. Consistent with this interpretation we have shown, in zebrafish, that mutant embryos lacking their pituitary ..
  35. THYROID HORMONE REGULATION OF NEURAL DEVELOPMENT
    GAIL BURD; Fiscal Year: 2002
    ..The goal of this research is to provide insight into thyroid hormone regulation of olfactory system development using an experimentally-favorable model system. ..
  36. Integrative mechanisms of cortical circuits
    GORDON MURRAY SHEPHERD; Fiscal Year: 2010
    ..The results will therefore suggest new principles for the functioning of cortical modules, and for the neural basis of normal odor processing. ..
  37. Targeting the Apical Surface of Human Airway Epithelia
    PAOLA DRAPKIN; Fiscal Year: 2003
    ..The major goals of this proposal are to generate candidate-targeting molecules with the hope of increasing efficiency of gene transfer vectors to the airways. ..
  38. Distribution and Role of CaMKII in Mouse Olfactory Bulb
    Dong Jing Zou; Fiscal Year: 2003
    ..In particular, we will investigate whether CaMKII activity regulates the development of granule cells, the most abundant neurons in the olfactory bulb. ..
  39. Development of the primary olfactory pathway
    Helen Treloar; Fiscal Year: 2009
    ..Axons penetrate the telencephalon, forming a presumptive olfactory nerve layer (pONL)...
  40. OLFACTORY AXON REGULATE OLFACTORY BULB CYTOGENESIS
    Qizhi Gong; Fiscal Year: 2003
    ..The determination of critical regulatory steps during cytogenesis will facilitate further analysis of the molecular players involved in this process. ..
  41. PROPERTIES OF OLFACTORY RECEPTORS - NEURAL REGENERATION
    RICHARD COSTANZO; Fiscal Year: 2009
    ..An established model of olfactory nerve injury will be used to investigate the role of MMPs following nerve injury and recovery processes during the ..
  42. NPY DEPRESSION OF HIPPOCAMPAL EPILEPSY
    Anthony van den Pol; Fiscal Year: 2002
    ..NPY is potentially of great interest because its primary action in the normal hippocampus appears to be one of depressing hyperexcited neurons, without a substantial effect on normal neurotransmission. ..
  43. ODORANT-RECEPTOR INTERACTIONS IN OLFACTORY NEURONS
    Thomas Getchell; Fiscal Year: 2005
    ..Understanding the signaling regulating neurogenesis in the OE will yield insights into mechanisms for restoring olfactory function compromised by aging, trauma, and neurodegenerative diseases. ..
  44. FUNCTION OF TAURINE IN THE PRIMARY OLFACTORY PATHWAY
    Igor Kratskin; Fiscal Year: 2003
    ..These studies will demonstrate the function of taurine in the olfactory epithelium and potential mechanisms of taurine action on primary olfactory neurons. ..
  45. Cytokine activation of neurons
    CAROL REISS; Fiscal Year: 2009
    ..They elucidate previously unsuspected interactions between the immune system and the central nervous system. ..
  46. Extracellular matrix in chloracetanilide carcinogenesis
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  47. Sphingolipid signaling in olfactory mucosa
    Mary Beth Genter; Fiscal Year: 2004
    ..abstract_text> ..
  48. DEVELOPMENT OF THE GUSTATORY SYSTEM
    RICHARD NORTHCUTT; Fiscal Year: 2005
    ..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
  49. IMPROVED CELL COUNTING USING THE OPTICAL DISECTOR
    CHRISTOPHER VON BARTHELD; Fiscal Year: 2004
    ....
  50. Gap Junctions and Connexins in Developing CNS
    JOHN RASH; Fiscal Year: 2005
    ....
  51. OLFACTION IN EPILEPSY
    RICHARD DOTY; Fiscal Year: 2004
    ..In addition to providing a better understanding of the influences of TLE and TLR on human olfactory function, this work may lead to the development of a simple and inexpensive non-invasive means for better establishing TLE seizure loci. ..
  52. NEURAL CIRCUITRY MEDIATING SUCROSE INDUCED ANALGESIA
    Matthew Ennis; Fiscal Year: 2003
    ..This work will lead to a better understanding of neural circuits controlling taste and pain and how these circuits regulate analgesia in newborns. ..
  53. PHYSIOLOGICAL ANALYSIS OF THE OLFACTORY PROJECTIONS
    John Scott; Fiscal Year: 2006
    ..These results will be of importance for understanding the sense of smell. ..
  54. Odorant Receptors and Functional Mapping
    Thomas Bozza; Fiscal Year: 2004
    ..The general approach of targeting expression of exogenous proteins (e.g., genetically encoded optical indicators) to defined neuronal populations could provide new methods to monitor neuronal activity in intact neuronal circuits. ..
  55. Analgesic effects of adrenal chromaffin cell transplants
    George Pappas; Fiscal Year: 2007
    ..abstract_text> ..
  56. Genetic approaches to image neural activity in the brain
    Thomas Bozza; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  57. Senselab: Integration of Multidisciplinary Sensory Data
    Gordon Shepherd; Fiscal Year: 2008
    ..abstract_text> ..
  58. DEVELOPMENT OF OLFACTORY CONNECTIONS
    Qizhi Gong; Fiscal Year: 2007
    ..of the differentiation and the targeting of the mitral cell dendrites, the postsynaptic partner of the olfactory nerve. We propose to investigate the following hypotheses concerning the control of mitral/tufted cell ..
  59. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    JOHN RASH; Fiscal Year: 2007
    ..abstract_text> ..
  60. GABA: EXCITATORY TRANSMITTER IN DEVELOPING HYPOTHALAMUS
    Anthony van den Pol; Fiscal Year: 2008
    ..GABA's excitatory actions during development are widespread throughout the brain. Thus, what we learn from our experiments on hypothalamic neurons should have general applicability to other CNS neurons. ..
  61. VSV INFECTION OF THE CENTRAL NERVOUS SYSTEM
    CAROL REISS; Fiscal Year: 2005
    ..This work has both basic and clinical applications, as viral encephalitis and pathological changes in the BBB are important medical problems. ..
  62. REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENT
    Anthony S LaMantia; Fiscal Year: 2010
    ....
  63. POSTMENOPAUSAL ESTROGEN INFLUENCES ON OLFACTION
    RICHARD DOTY; Fiscal Year: 2005
    ..Third, it would lead to testable hypotheses regarding the role of reproductive hormones, and their underlying mechanisms, in the maintenance of normal olfactory function. ..