nociceptors

Summary

Summary: Peripheral receptors for pain. Nociceptors include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. All nociceptors are free nerve endings.

Top Publications

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
  3. ncbi Models and mechanisms of hyperalgesia and allodynia
    Jürgen Sandkühler
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Physiol Rev 89:707-58. 2009
  4. ncbi Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
  5. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
  6. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
  7. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
  8. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
  9. ncbi TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 50:277-89. 2006
  10. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004

Detail Information

Publications317 found, 100 shown here

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo...
  2. pmc Cellular and molecular mechanisms of pain
    Allan I Basbaum
    Department of Anatomy, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 139:267-84. 2009
    ..Genetic, electrophysiological, and pharmacological studies are elucidating the molecular mechanisms that underlie detection, coding, and modulation of noxious stimuli that generate pain...
  3. ncbi Models and mechanisms of hyperalgesia and allodynia
    Jürgen Sandkühler
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Physiol Rev 89:707-58. 2009
    ..Refined definitions of some technical terms including the new definitions of hyperalgesia and allodynia by the International Association for the Study of Pain are illustrated and annotated in section I...
  4. ncbi Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
    ..These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions...
  5. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
    ..Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol...
  6. ncbi TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell 124:1269-82. 2006
    ..we now show that this channel is the sole target through which mustard oil and garlic activate primary afferent nociceptors to produce inflammatory pain...
  7. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
    ....
  8. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors...
  9. ncbi TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 50:277-89. 2006
    ..TRPA1 is apparently not essential for hair-cell transduction but contributes to the transduction of mechanical, cold, and chemical stimuli in nociceptor sensory neurons...
  10. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain...
  11. ncbi Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity
    R R Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Rm 4309, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 2:1114-9. 1999
    ..ERK signaling within the spinal cord is therefore involved in generating pain hypersensitivity. Because of its rapid activation, this effect probably involves regulation of neuronal excitability without changes in transcription...
  12. pmc Descending control of nociception: Specificity, recruitment and plasticity
    M M Heinricher
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, USA
    Brain Res Rev 60:214-25. 2009
    ....
  13. ncbi Nociceptors--noxious stimulus detectors
    Clifford J Woolf
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Neuron 55:353-64. 2007
    In order to deal effectively with danger, it is imperative to know about it. This is what nociceptors do--these primary sensory neurons are specialized to detect intense stimuli and represent, therefore, the first line of defense against ..
  14. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  15. ncbi The cell and molecular basis of mechanical, cold, and inflammatory pain
    Bjarke Abrahamsen
    Molecular Nociception Group, University College London UCL, Gower Street, London, WC1E 6BT, UK
    Science 321:702-5. 2008
    ..These data demonstrate that Na(v)1.8-expressing neurons are essential for mechanical, cold, and inflammatory pain but not for neuropathic pain or heat sensing...
  16. ncbi painless, a Drosophila gene essential for nociception
    W Daniel Tracey
    Division of Biology 156 29, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 113:261-73. 2003
    ..An antibody to Painless binds to localized dendritic structures that we hypothesize are involved in nociceptive signaling...
  17. pmc TRPA1 mediates mechanical sensitization in nociceptors during inflammation
    Richard C Lennertz
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin, United States of America
    PLoS ONE 7:e43597. 2012
    ....
  18. ncbi Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system
    Shannon D Shields
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
    Pain 153:2017-30. 2012
    ..expressed in small-diameter unmyelinated sensory afferents specialized for the detection of noxious stimuli (nociceptors), and Na(v)1.8-Cre mice have been widely used to investigate gene function in nociceptors...
  19. ncbi Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    Mark J Zylka
    Division of Biology, 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 45:17-25. 2005
    ..Thus, afferent input from different layers of the epidermis is conveyed by topographically segregated sensory circuits, suggesting that at least some aspects of sensory information processing may be organized along labeled lines...
  20. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    ..These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects...
  21. pmc Pungent products from garlic activate the sensory ion channel TRPA1
    Diana M Bautista
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 102:12248-52. 2005
    ..Thus different plant genera, including Allium and Brassica, have developed evolutionary convergent strategies that target TRPA1 channels on sensory nerve endings to achieve chemical deterrence...
  22. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
    Peripheral inflammation induces p38 MAPK activation in the soma of C fiber nociceptors in the dorsal root ganglion (DRG) after 24 hr...
  23. pmc Methylglyoxal activates nociceptors through transient receptor potential channel A1 (TRPA1): a possible mechanism of metabolic neuropathies
    Mirjam J Eberhardt
    Institute of Physiology and Pathophysiology Friedrich Alexander University Erlangen Nuremberg, Universitaetsstrasse 17, 91054 Erlangen, Germany
    J Biol Chem 287:28291-306. 2012
    ..fibers, and stimulating release of proinflammatory neuropeptides from and action potential firing in cutaneous nociceptors. Using a model peptide of the N terminus of human TRPA1, we demonstrate the formation of disulfide bonds based ..
  24. pmc TREK-1, a K+ channel involved in polymodal pain perception
    Abdelkrim Alloui
    Laboratoire de Pharmacologie Médicale EA 3848 INSERM Faculté de Médecine CHU, Clermont Ferrand, France
    EMBO J 25:2368-76. 2006
    ..TREK-1 appears as an important ion channel for polymodal pain perception and as an attractive target for the development of new analgesics...
  25. ncbi Sodium channels in normal and pathological pain
    Sulayman D Dib-Hajj
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Neurosci 33:325-47. 2010
    ..Na(v)1.7 is of special interest because it has been linked to a spectrum of inherited human pain disorders. Here we review the contribution of these sodium channel isoforms to pain...
  26. pmc TRPA1 is a component of the nociceptive response to CO2
    Yuanyuan Y Wang
    Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, California 90089, USA
    J Neurosci 30:12958-63. 2010
    ..The stinging sensation is thought to originate with the activation of nociceptors, which innervate the respiratory, nasal, and oral epithelia. The molecular basis for this sensation is unknown...
  27. pmc Differential ATF3 expression in dorsal root ganglion neurons reveals the profile of primary afferents engaged by diverse noxious chemical stimuli
    Joao M Braz
    Department of Anatomy, WM Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94158, USA
    Pain 150:290-301. 2010
    ..We conclude that purportedly selective agonists can activate a heterogeneous population of sensory neurons, which ultimately could contribute to the behavioral responses evoked...
  28. pmc TRPA1 modulates mechanotransduction in cutaneous sensory neurons
    Kelvin Y Kwan
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 29:4808-19. 2009
    ..C-fiber nociceptors from Trpa1(-/-) mice exhibited action potential firing rates 50% lower than those in wild-type C-fibers across ..
  29. pmc Nociceptive neurons protect Drosophila larvae from parasitoid wasps
    Richard Y Hwang
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Curr Biol 17:2105-16. 2007
    ..In response, the larvae "roll" with a motor pattern that is completely distinct from the style of locomotion that is used for foraging...
  30. ncbi Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals
    Laiche Djouhri
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Brain Res Brain Res Rev 46:131-45. 2004
    The existence of nociceptors with Abeta-fibers has often been overlooked, and many textbooks endorse the view that all nociceptors have either C- or Adelta-fibers...
  31. ncbi A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons
    X Dong
    Division of Biology 216-76, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 106:619-32. 2001
    ..Thus, mrgs may regulate nociceptor function and/or development, including the sensation or modulation of pain...
  32. pmc Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
    Isaac M Chiu
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 15:1063-7. 2012
    ..Therefore, understanding the coordinated interaction of peripheral neurons with immune cells may advance therapeutic approaches to increase host defense and suppress immunopathology...
  33. ncbi Midbrain control of spinal nociception discriminates between responses evoked by myelinated and unmyelinated heat nociceptors in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, University of Sydney, Sydney, Australia
    Pain 124:59-68. 2006
    ..Myelinated (A-fibre) and unmyelinated (C-fibre) nociceptors convey different qualities of the pain signal (first and second pain, respectively), and they play different ..
  34. ncbi Cyclin-dependent kinase 5 controls TRPV1 membrane trafficking and the heat sensitivity of nociceptors through KIF13B
    Bao Ming Xing
    Neuroscience Research Institute and Department of Neurobiology, The Key Laboratory for Neuroscience of the Ministry of Education and Health, Peking University Health Science Center, Beijing 100191, China
    J Neurosci 32:14709-21. 2012
    ..Cdk5 regulation of TRPV1 membrane trafficking is a fundamental mechanism controlling the heat sensitivity of nociceptors, and moderate inhibition of Thr-506 phosphorylation during inflammation might be helpful for the treatment of ..
  35. ncbi Neuropathic pain: redefinition and a grading system for clinical and research purposes
    R D Treede
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Neurology 70:1630-5. 2008
    ..The grades probable and definite require confirmatory evidence from a neurologic examination. This grading system is proposed for clinical and research purposes...
  36. ncbi A capsaicin-receptor homologue with a high threshold for noxious heat
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 398:436-41. 1999
    ..We propose that responses to noxious heat involve these related, but distinct, ion-channel subtypes that together detect a range of stimulus intensities...
  37. ncbi HCN2 ion channels play a central role in inflammatory and neuropathic pain
    Edward C Emery
    Department of Pharmacology, University of Cambridge, Cambridge CB2 1PD, UK
    Science 333:1462-6. 2011
    The rate of action potential firing in nociceptors is a major determinant of the intensity of pain...
  38. ncbi Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
    W Magerl
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Brain 124:1754-64. 2001
    Polymodal nociceptors respond to mechanical, thermal and chemical stimuli...
  39. pmc Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo
    X Fang
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 1TD, UK
    J Physiol 565:927-43. 2005
    ..AP overshoots and AHP durations were similar in nociceptors of all CV groups whereas AP durations were greater in slowly conducting, especially C-fibre, nociceptors...
  40. pmc The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
    Laiche Djouhri
    Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
    J Physiol 550:739-52. 2003
    ..C-unresponsive units had electrical membrane properties similar to C-nociceptors and were considered to be nociceptive-type neurons. Weak positive Nav1...
  41. pmc The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions
    Yuanyuan Y Wang
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
    J Biol Chem 283:32691-703. 2008
    ..In conclusion, we have further clarified the mechanisms of potentiation and inactivation of TRPA1 using the D918A pore mutant, an important tool for investigating the contribution of Ca(2+) influx through TRPA1 to nociceptive signaling...
  42. pmc Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor
    Jennifer K Bonnington
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    J Physiol 551:433-46. 2003
    ..These data indicate that the crucial early pathway activated by NGF involves PI3K, while PKC and CaMK II are also involved, probably at subsequent stages of the NGF-activated signalling pathway...
  43. ncbi Inhibition of nociceptors by TRPV1-mediated entry of impermeant sodium channel blockers
    Alexander M Binshtok
    Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nature 449:607-10. 2007
    ..Here we show that charged sodium-channel blockers can be targeted into nociceptors by the application of TRPV1 agonists to produce a pain-specific local anaesthesia...
  44. pmc Laminar organization of spinal dorsal horn neurones activated by C- vs. A-heat nociceptors and their descending control from the periaqueductal grey in the rat
    Stella Koutsikou
    Department of Physiology, School of Medical Sciences, University Walk, University of Bristol, UK
    Eur J Neurosci 26:943-52. 2007
    ..neurones expressing Fos-like immunoreactivity were determined following preferential activation of A- or C-heat nociceptors, using fast or slow rates of skin heating, respectively, in the absence or presence of descending control ..
  45. ncbi Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception
    J S Mogil
    Department of Psychology, University of Illinois at Urbana Champaign, Champaign 61820, USA
    Pain 80:67-82. 1999
    ..30-0.76) and mediation by a limited number of apparent genetic loci. Data comparing inbred strains have considerable utility as a tool for understanding the genetics of nociception, and a particular relevance to transgenic studies...
  46. ncbi Endogenous mechanisms underlying the activation and sensitization of meningeal nociceptors: the role of immuno-vascular interactions and cortical spreading depression
    Dan Levy
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA
    Curr Pain Headache Rep 16:270-7. 2012
    ..evidence that CSD is indeed a powerful endogenous process that can lead to persistent activation of meningeal nociceptors and the migraine pain pathway...
  47. pmc Spinal dorsal horn neuronal responses to myelinated versus unmyelinated heat nociceptors and their modulation by activation of the periaqueductal grey in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    J Physiol 576:547-56. 2006
    ..this study was to further understand the central processing of inputs arising from unmyelinated and myelinated nociceptors by (i) determining the response characteristics of Class 2 dorsal horn neurones to preferential activation of C-..
  48. pmc MAP kinase and pain
    Ru Rong Ji
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, MRB 604, Boston, MA 02115, USA
    Brain Res Rev 60:135-48. 2009
    ..Although it is well documented that MAPK pathways can increase pain sensitivity via peripheral mechanisms, this review will focus on central mechanisms of MAPKs, especially ERK...
  49. ncbi The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors
    Karla P Zeitz
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 22:1010-9. 2002
    ..Specifically, in the setting of tissue injury, the 5-HT(3) receptor mediates activation of nociceptors but does not contribute to injury-associated edema...
  50. pmc Transient receptor potential channels: targeting pain at the source
    Ardem Patapoutian
    The Scripps Research Institute, 10550 North Torrey Pines Road, ICND210F, La Jolla, California 92037, USA
    Nat Rev Drug Discov 8:55-68. 2009
    ..novel analgesics is to target the beginning of the pain pathway, and aim potential treatments directly at the nociceptors--the high-threshold primary sensory neurons that detect noxious stimuli...
  51. pmc RET signaling is required for survival and normal function of nonpeptidergic nociceptors
    Judith P Golden
    Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:3983-94. 2010
    Small unmyelinated sensory neurons classified as nociceptors are divided into two subpopulations based on phenotypic differences, including expression of neurotrophic factor receptors...
  52. pmc Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors
    Stuart M Chambers
    Center for Stem Cell Biology, Sloan Kettering Institute, New York, New York, USA
    Nat Biotechnol 30:715-20. 2012
    ..The resulting neurons express canonical markers and functional properties of human nociceptors, including tetrodotoxin (TTX)-resistant, SCN10A-dependent sodium currents and response to nociceptive stimuli ..
  53. ncbi Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
    G Wu
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 21:RC140. 2001
    ..Discharge of injured nociceptors has been presumed to play a role in generating the pain...
  54. ncbi Central mechanisms of pathological pain
    Rohini Kuner
    Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld, 366 Heidelberg, Germany
    Nat Med 16:1258-66. 2010
    ..This review focuses on the molecular determinants of network plasticity in the central nervous system (CNS) and discusses their relevance to the development of new therapeutic approaches...
  55. pmc Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain
    Juan M Jimenez-Andrade
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 30:14649-56. 2010
    ..Therapies that prevent this reorganization of sensory nerve fibers may provide insight into the evolving mechanisms that drive cancer pain and lead to more effective control of this chronic pain state...
  56. pmc Chronic spontaneous activity generated in the somata of primary nociceptors is associated with pain-related behavior after spinal cord injury
    Supinder S Bedi
    Department of Integrative Biology and Pharmacology, University of Texas Medical School at Houston, Houston, Texas 77030, USA
    J Neurosci 30:14870-82. 2010
    ..These events might also impact central processes of primary sensory neurons, triggering in nociceptors a hyperexcitable state and spontaneous activity (SA) that drive behavioral hypersensitivity and pain...
  57. ncbi Chronic inflammatory pain is associated with increased excitability and hyperpolarization-activated current (Ih) in C- but not Aδ-nociceptors
    Xiechuan Weng
    Department of Clinical and Molecular Pharmacology, Institute of Translational Medicine, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, UK
    Pain 153:900-14. 2012
    ..induced by complete Freund's adjuvant (CFA), we demonstrate increased excitability of C- but not Aδ-nociceptors, 5 to 7 days after CFA...
  58. ncbi Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
    ..Percentages of nociceptive-type C-fiber neurons (C-nociceptors) with SA increased in intact L4 but not axotomized L5 DRGs in SNA and mSNA (to 35%), and in L4/L5 DRGs 1-4 d ..
  59. pmc TRPA1 contributes to cold hypersensitivity
    Donato Del Camino
    Hydra Biosciences, Inc, Cambridge, Massachusetts 02139, USA
    J Neurosci 30:15165-74. 2010
    TRPA1 is a nonselective cation channel expressed by nociceptors. Although it is widely accepted that TRPA1 serves as a broad irritancy receptor for a variety of reactive chemicals, its role in cold sensation remains controversial...
  60. ncbi A key role for gp130 expressed on peripheral sensory nerves in pathological pain
    Manfred Andratsch
    Department of Physiology and Medical Physics, Division of Physiology, Innsbruck Medical University, Innsbruck, Austria
    J Neurosci 29:13473-83. 2009
    ..may enhance pain not only indirectly through their proinflammatory actions but also through a direct action on nociceptors (i.e., on neurons activated by painful stimuli)...
  61. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
    ..8-expressing nociceptors was abolished...
  62. ncbi Ectopic discharge in Abeta afferents as a source of neuropathic pain
    Marshall Devor
    Department of Cell and Developmental Biology, Institute of Life Sciences and Center for Research on Pain, Hebrew University of Jerusalem, 91904 Jerusalem, Israel
    Exp Brain Res 196:115-28. 2009
    ..This dual phenotypic switching renders them capable of (1) directly driving postsynaptic pain signaling pathways in the spinal cord, and (2) triggering and maintaining central sensitization...
  63. pmc Inflammatory mediators increase Nav1.9 current and excitability in nociceptors through a coincident detection mechanism
    Francois Maingret
    CRN2M, CNRS, Universit é de la M é diterran é e, 13916 Marseille Cedex 20, France
    J Gen Physiol 131:211-25. 2008
    ..9 channel current signature and its impact on nociceptors' firing patterns. Recordings using internal fluoride in small DRG neurons from wild-type and Nav1...
  64. ncbi Chemical response pattern of different classes of C-nociceptors to pruritogens and algogens
    M Schmelz
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nuremberg, Germany
    J Neurophysiol 89:2441-8. 2003
    ..were used in microneurography experiments to characterize the sensitivity profile of human cutaneous C-nociceptors. The responses of 89 mechanoresponsive (CMH, polymodal nociceptors), 52 mechanoinsensitive, histamine-negative (..
  65. ncbi Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain
    R R Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Neurobiol Dis 8:1-10. 2001
    ..Pharmacological intervention targeted specifically at the signal transduction pathways in nociceptive neurons may provide, therefore, new therapeutic opportunities for pathological pain...
  66. ncbi Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons
    Nathaniel T Blair
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 20114, USA
    J Neurosci 22:10277-90. 2002
    ....
  67. pmc From nociception to pain perception: imaging the spinal and supraspinal pathways
    Jonathan Brooks
    Pain Imaging Neuroscience Group, Department of Human Anatomy and Genetics, University of Oxford, UK
    J Anat 207:19-33. 2005
    ..The ultimate goal of such research is to take these new techniques into the clinic, to investigate and provide new remedies for chronic pain sufferers...
  68. pmc Hyperalgesic priming is restricted to isolectin B4-positive nociceptors
    E K Joseph
    Division of Neuroscience, Departments of Medicine and Oral and Maxillofacial Surgery, University of California, San Francisco, CA 94143, USA
    Neuroscience 169:431-5. 2010
    We have previously described a rat model for the contribution of neuroplastic changes in nociceptors to the transition from acute to chronic pain...
  69. pmc Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura
    Xichun Zhang
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, and Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 30:8807-14. 2010
    ..cortical spreading depression (CSD)--an event believed to underlie visual aura--can give rise to activation of nociceptors that innervate the meninges--an event believed to set off migraine headache...
  70. ncbi Disinhibition opens the gate to pathological pain signaling in superficial neurokinin 1 receptor-expressing neurons in rat spinal cord
    Carole Torsney
    Department of Physiology and Cellular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 26:1833-43. 2006
    ..These disinhibition-induced changes, in particular the novel polysynaptic low-threshold input onto lamina I NK1R+ neurons, may be an underlying component of the hypersensitivity present in chronic pain states...
  71. pmc Nociceptors are interleukin-1beta sensors
    Alexander M Binshtok
    Neural Plasticity Research Group, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 28:14062-73. 2008
    ..and nerve growth factor, that reduce the threshold and increase the excitability of the peripheral terminals of nociceptors so that they now respond to innocuous stimuli: the phenomenon of peripheral sensitization...
  72. ncbi ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors
    William A Schmalhofer
    Department of Ion Channels, Merck Research Laboratories, Rahway, NJ 07065 0900, USA
    Mol Pharmacol 74:1476-84. 2008
    ..Thus, the (125)I-ProTx-II binding assay, described here, offers a new tool in the search for novel Na(V)1.7-selective blockers...
  73. pmc A subpopulation of nociceptors specifically linked to itch
    Liang Han
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Neurosci 16:174-82. 2013
    ..These data suggest that MrgprA3 defines a specific subpopulation of DRG neurons mediating itch. Our study opens new avenues for studying itch and developing anti-pruritic therapies...
  74. pmc Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing
    Carolina Roza
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Physiol 558:659-69. 2004
    ..We investigated the effect of an ASIC2 gene knockout in mice on hearing and on cutaneous mechanosensation and visceral mechanonociception. However, our data do not support a role of ASIC2 in those facets of mechanoperception...
  75. pmc Cytokine signaling mediates UV-induced nociceptive sensitization in Drosophila larvae
    Daniel T Babcock
    Department of Biochemistry and Molecular Biology, University of Texas Graduate School of Biomedical Sciences, USA
    Curr Biol 19:799-806. 2009
    ..Multiple mediators of nociceptive sensitization have been identified in vertebrates, but the complexity of the vertebrate nervous system and tissue-repair responses has hindered identification of the precise roles of these factors...
  76. pmc Presynaptic Cav3.2 channels regulate excitatory neurotransmission in nociceptive dorsal horn neurons
    Megan O Jacus
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosci 32:9374-82. 2012
    ..These studies provide previously unknown information regarding the role of presynaptic T-channels in nociceptive signaling in the spinal cord...
  77. ncbi A reliable method for the preferential activation of C- or A-fibre heat nociceptors
    Simon McMullan
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Neurosci Methods 138:133-9. 2004
    There is strong evidence that A- and C-fibre nociceptors evoke significantly different sensory experiences, are differentially sensitive to pharmacological intervention, and play different roles in pain pathology...
  78. ncbi Activity-dependent development of tactile and nociceptive spinal cord circuits
    Stephanie C Koch
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom
    Ann N Y Acad Sci 1279:97-102. 2013
    ....
  79. pmc Nociceptors: a phylogenetic view
    Ewan St John Smith
    Department of Neuroscience, Max Delbruck Center for Molecular Medicine, 13125 Berlin Buch, Germany
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 195:1089-106. 2009
    ..by the fact that most animals have dedicated sensory afferents which respond to noxious stimuli called nociceptors. Should injury occur there is often sensitization, whereby increased nociceptor sensitivity and/or plasticity ..
  80. pmc Roles of transient receptor potential channels in pain
    Cheryl L Stucky
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Brain Res Rev 60:2-23. 2009
    Pain perception begins with the activation of primary sensory nociceptors. Over the past decade, flourishing research has revealed that members of the Transient Receptor Potential (TRP) ion channel family are fundamental molecules that ..
  81. ncbi Spinal modulation of nociception by music
    M Roy
    BRAMS Laboratory, Department of Psychology, University of Montreal, Canada
    Eur J Pain 16:870-7. 2012
    ..There were no significant differences between the pleasant-stimulating and pleasant-relaxing musical condition, indicating that the arousal of music had little influence on pain processing...
  82. pmc Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain
    Mohammed A Nassar
    Molecular Nociception Group, Biology Department, and Pharmacology Department, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 101:12706-11. 2004
    ..7 in inflammatory pain. Nociceptor-specific gene ablation should prove useful in understanding the role of other broadly expressed genes in pain pathways...
  83. ncbi Excitatory nicotinic and desensitizing muscarinic (M2) effects on C-nociceptors in isolated rat skin
    N Bernardini
    Institut fur Physiologie und Experimentelle Pathophysiologie, Erlangen Universität, Universitätstrasse 17, 91054 Erlangen, Germany
    J Neurosci 21:3295-302. 2001
    ..Nicotine was able to weakly excite C-nociceptors and to induce a mild sensitization to heat stimulation (in 77% of tested fibers) in a dose-dependent manner (10(..
  84. ncbi Alternative splicing matters: N-type calcium channels in nociceptors
    Diane Lipscombe
    Department Neuroscience, Brown University, Providence, Rhode Island 02912, USA
    Channels (Austin) 1:225-7. 2007
    ..Combined with our previous studies that show enrichment of e37a in nociceptors, our data suggest a molecular basis for the high susceptibility of N-type currents in sensory neurons to ..
  85. ncbi Low intensity intra-epidermal electrical stimulation can activate Aδ-nociceptors selectively
    A Mouraux
    Institute of Neurosciences IoNS, Universite Catholique de Louvain, Belgium
    Pain 150:199-207. 2010
    In the past 30years, the study of nociception has relied mostly on thermal stimulation to activate nociceptors selectively. However, thermal stimulation suffers from some important limitations...
  86. ncbi Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat
    X Chen
    Departments of Anatomy, Medicine, and Oral and Maxillofacial Surgery, Division of Neuroscience, NIH Pain Center (UCSF, University of California, San Francisco 94143-0440, USA
    Neuroscience 102:185-92. 2001
    ..The present findings suggest that study of individual neurons in vitro may allow elucidation of the ionic basis of enhanced nociception in diabetic neuropathy...
  87. ncbi Botulinum neurotoxin type A (BoNTA) decreases the mechanical sensitivity of nociceptors and inhibits neurogenic vasodilation in a craniofacial muscle targeted for migraine prophylaxis
    Parisa Gazerani
    The Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, Canada
    Pain 151:606-16. 2010
    ..study, the effect of BoNTA on the mechanical and chemical responsiveness of individual temporalis muscle nociceptors and muscle neurogenic vasodilation was investigated in female rats...
  88. ncbi Can we conquer pain?
    Joachim Scholz
    Neural Plasticity Research Group, Department of Anesthesia, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Nat Neurosci 5:1062-7. 2002
    ..Elucidation of these mechanisms is key to the development of treatments that specifically target underlying causes rather than just symptoms. This new approach promises to revolutionize pain diagnosis and management...
  89. pmc Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors
    Daniel Vilceanu
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    J Pain 11:588-99. 2010
    ..The TRPV1 channel expressed by nociceptors is one receptor for noxious heat and inflammatory molecules...
  90. ncbi Mechanical and heat sensitization of cutaneous nociceptors in rats with experimental peripheral neuropathy
    B Shim
    Brain Research Institute, Brain Korea 21 Project for Medical Science, and Department of Physiology, Yonsei University College of Medicine, C P O Box 8044, 120 752, Seoul, South Korea
    Neuroscience 132:193-201. 2005
    ..These results suggest that after a partial peripheral nerve injury, the nociceptors on the skin supplied by an uninjured nerve become sensitized to both mechanical and heat stimuli...
  91. ncbi Genetic ablation of delta opioid receptors in nociceptive sensory neurons increases chronic pain and abolishes opioid analgesia
    Claire Gaveriaux-Ruff
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Neurobiology and Genetic Department, Illkirch F 67400, France
    Pain 152:1238-48. 2011
    ..The conditional knockout of delta-opioid receptor in primary afferent Na(V)1.8 neurons augmented mechanical allodynia in persistent pain models and abolished delta opioid analgesia in these models...
  92. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
    ..Instead, central sensitization produces pain hypersensitivity by changing the sensory response elicited by normal inputs, including those that usually evoke innocuous sensations...
  93. pmc Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease
    Cheryl A Hillery
    Department of Pediatrics and Children s Research Institute, Division of Hematology Oncology, Medical College of Wisconsin, Milwaukee, WI, USA
    Blood 118:3376-83. 2011
    ..Therefore, TRPV1-targeted compounds that lack thermoregulatory side effects may provide relief from pain in patients with SCD...
  94. pmc An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors
    Annika S Stürzebecher
    Molecular Neurobiology Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Strasse 10, 13125 Berlin, Germany
    J Physiol 588:1695-707. 2010
    ..Primary afferent nociceptors, which detect painful stimuli, are enriched in specific voltage-gated sodium channel (VGSC) subtypes...
  95. pmc Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity
    Ceng Luo
    Pharmacology Institute, University of Heidelberg, Heidelberg, Germany
    PLoS Biol 10:e1001283. 2012
    ..P system, we generated nociceptor-specific knockout mice lacking PKG-I specifically in presynaptic terminals of nociceptors in the spinal cord, but not in post-synaptic neurons or elsewhere (SNS-PKG-I(-/-) mice)...
  96. ncbi Increased hyperalgesia after tissue injury and faster recovery of allodynia after nerve injury in the GalR1 knockout mice
    S Malkmus
    Department of Anesthesiology Research Laboratory, University of California, San Diego, USA
    Neuropeptides 39:217-21. 2005
    ..These results are consistent with a regulatory effect of galanin at GalR1 receptors on nociceptive processing...
  97. pmc VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity
    Gregory Scherrer
    Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 107:22296-301. 2010
    Dorsal root ganglia (DRG) neurons, including the nociceptors that detect painful thermal, mechanical, and chemical stimuli, transmit information to spinal cord neurons via glutamatergic and peptidergic neurotransmitters...
  98. ncbi Differential galanin upregulation in dorsal root ganglia and spinal cord after graded single ligature nerve constriction of the rat sciatic nerve
    María Florencia Coronel
    School of Biomedical Sciences, Austral University, Av Pte Perón 1500, B1629AHJ Pilar, Buenos Aires, Argentina
    J Chem Neuroanat 35:94-100. 2008
    ..These results show that galanin expression in DRGs and spinal cord is differentially regulated by different degrees of nerve constriction and further support its modulatory role on neuropathic pain...
  99. ncbi Sensitization of rat dorsal horn neurons by NGF-induced subthreshold potentials and low-frequency activation. A study employing intracellular recordings in vivo
    Ulrich Hoheisel
    Institute of Pharmacology and Toxicology, Charite, Humboldt University, Dorotheenstrasse 94, D 10117 Berlin, Germany
    Brain Res 1169:34-43. 2007
    ..m. The data demonstrate that low-frequency activation or even subthreshold potentials in dorsal horn neurons evoked by unmyelinated muscle afferents are an effective means of sensitizing these neurons...
  100. ncbi Understanding inflammatory pain: ion channels contributing to acute and chronic nociception
    John E Linley
    Institute of Membrane and Systems Biology, Faculty of Biological Sciences, University of Leeds, LS29JT Leeds, UK
    Pflugers Arch 459:657-69. 2010
    ....
  101. ncbi Excitation and sensitization of nociceptors by bradykinin: what do we know?
    Kazue Mizumura
    Division of Stress Recognition and Response, Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    Exp Brain Res 196:53-65. 2009
    ..Correspondingly, it excites nociceptors in various tissues and sensitizes them to heat, whereas sensitizing effect on the mechanical response of ..

Research Grants74

  1. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..of position, touch, and pain signals throughout the body, conveyed by proprioceptors, mechanoreceptors, and nociceptors, respectively...
  2. EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONS
    Sanjay Jain; Fiscal Year: 2013
    ..provided by applicant): This is a Research Project to generate expression profiles of a specific population of nociceptors in the dorsal root sensory ganglia (DRG) during development and postnatal period in mice as a part of the ..
  3. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..We further showed that a signal-transduction complex is present in nociceptors, composed of the NGF receptor (TrkA), TRPV1, and the enzyme PI3K, which phosphorylates phosphoinositide 4,5-..
  4. Mapping Orofacial Nociceptive Pathways and Alterations Due to Inflammation
    JOSHUA EMRICK; Fiscal Year: 2013
    ..Nociception is the process whereby noxious stimuli activate primary afferent sensory neurons (nociceptors) producing pain via signaling to the central nervous system (CNS) and contributing to inflammation by releasing ..
  5. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..DRRs that cause the release of calcitonin gene-related peptide and/or substance P from primary afferent nociceptors and if this process would in turn enhance the CAP-induced sensitization of primary afferent nociceptors, as ..
  6. The role of trace metals and T-channels in pain
    Slobodan M Todorovic; Fiscal Year: 2013
    ..voltage-gated calcium channels (T-channels) play a key role in control of cellular excitability of peripheral nociceptors and thus represent promising new cellular targets for development of pain therapies...
  7. Regulation of TRPV1 and Nociceptor Sensitization by the Complement System
    Yuriy M Usachev; Fiscal Year: 2013
    ..hypothesize that C3a and C5a receptors are expressed and functionally coupled with TRPV1 in a subset of primary nociceptors;activation of these receptors sensitize nociceptors via protein kinase C-dependent modulation of the TRPV1 ..
  8. Neuron-specific block of T-type calcium channels
    Edward Perez-Reyes; Fiscal Year: 2012
    ..hypothesis guiding these exploratory studies is that chronic pain can be treated by inhibiting ion channels in nociceptors such as the Cav3.2 T-type voltage-gated calcium channel...
  9. Central TRPV1 in Cardiovascular Regulation
    MICHAEL CHRISTIAN ANDRESEN; Fiscal Year: 2013
    ..TRPV1) contribute to detection of noxious heat (>420C) and tissue damage by spinal primary afferent nociceptors. This proposal will examine the mechanisms by which TRPV1 expression in cranial primary afferents within the ..
  10. Mapping serotonin receptors in lower urinary tract innervation
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..The cell bodies of pain- sensing neurons, nociceptors, that innervate the lower urinary tract reside in the dorsal root ganglia amidst many other sensory neurons and ..
  11. Characteristics and mechanisms of pain in sickle cell disease
    DONALD SIMONE; Fiscal Year: 2013
    ..We hypothesize that persistent activation of nociceptors by inflammation, hypoxia- reperfusion injury and "crises" leads to central sensitization...
  12. Effects of Artemin on Nociceptors
    KATHRYN MARIE ALBERS; Fiscal Year: 2013
    ..We propose a mechanism by which Artn produces its effect that, if correct, may allow development of analgesic compounds that are effective in treating pain associated with chronic inflammatory disease. ..
  13. Novel Analgesics from Australian Funnel-Web Spider Venom
    MICHAEL NATHAN NITABACH; Fiscal Year: 2010
    Pain caused by activation of pain-sensing peripheral neurons ("nociceptors") is a major source of human suffering and economic loss...
  14. The Role of ASICs in Migraine Pathophysiology
    Gregory O Dussor; Fiscal Year: 2013
    ..Prior preclinical work has found that trigeminal pain-sensing neurons (nociceptors) innervating the cranial meninges (i.e. the dura mater) are sensitive to substances released from mast cells...
  15. Functional Interactions between Cancer Cells and Sensory Neurons
    DONALD SIMONE; Fiscal Year: 2012
    ..responses, neurodegeneration, and release of algesic substances from the cancer cells that excite or sensitize nociceptors on primary afferent fibers...
  16. Phenotyping pain in a mouse model of pancreatic cancer
    Brian M Davis; Fiscal Year: 2012
    ..and the production of neurotrophic factors that have been shown to regulate anatomy and function of adult nociceptors (e.g., NGF and artemin)...
  17. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..Transgenic mice that endogenously express GFP in restricted populations of nociceptors will be used in combination with immunohistochemistry to determine whether specific subpopulations of sensory ..
  18. Estrogen regulation of inflammatory mediator signaling
    William P Clarke; Fiscal Year: 2011
    ..overall hypothesis is that estrogens, acting via rapid signaling pathways, increase the responsiveness of TG nociceptors to stimulation by inflammatory mediators and that this plays a role in the enhanced pain sensitivity of women...
  19. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2013
    ..peripheral inflammation contributes to the generation of inflammatory pain by altering ion channel function in nociceptors. To achieve this objective three aims are proposed...
  20. Central mechanisms of maintenance of orofacial pain after injury
    Asaf Keller; Fiscal Year: 2013
    ..pain has advanced our knowledge of the initiation of pain hypersensitivity due to sensitization of peripheral nociceptors and neurons in the medullary and spinal dorsal horns as well as other sites in the central nervous system (CNS)...
  21. Peripheral Sensitization as a Novel Mechanism for Pain in Sickle Cell Disease
    Amanda M Brandow; Fiscal Year: 2013
    ..Chronic inflammation, including leukotrienes, has been shown to sensitize pain sensing nociceptors in non-SCD models...
  22. 7th World Congress on Itch (WCI)
    Ethan A Lerner; Fiscal Year: 2013
    ..and cancer [unreadable]Neuropathic itch [unreadable]Peripheral signaling of itch versus pain: pruriceptors, nociceptors, A-beta, delta and C-fibers [unreadable]Central signaling of itch by the spinothalamic tract and other pathways ..
  23. Function of Ret-GFL signaling in sensory neurons
    Judith Golden; Fiscal Year: 2009
    Small-diameter sensory neurons that sense pain are classified as nociceptors. During embryonic development virtually all nociceptors express TrkA, the receptor for the neurotrophic factor NGF, and depend on NGF for survival...
  24. Characterization and Plasticity of Visceral Nociceptors
    Brian M Davis; Fiscal Year: 2012
    ..expressed in a population that had previously been identified as mechanically sensitive, high threshold, nociceptors. Thus, the general hypothesis of the proposed studies is that visceral hyperalgesia is initiated by increased ..
  25. ESTROGEN MODULATION OF HUMAN NOCICEPTORS
    Kenneth M Hargreaves; Fiscal Year: 2012
    ..we have developed a method for evaluating estradiol enhancement of the exocytotic activity of peripheral human nociceptors innervating surgical biopsies of healthy tissue (evaluating substance P (SP) release from neuron terminals ..
  26. Mechanisms of postnatal cutaneous afferent development during inflammation
    Michael P Jankowski; Fiscal Year: 2013
    ..While much is known about the functional properties and plasticity of cutaneous nociceptors following peripheral injuries in adults, relatively little is known about the functiona properties of sensory ..
  27. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
    ..is signaled by generation of action potentials in a specific population of primary sensory neurons known as nociceptors. The most effective form of pain relief without loss of consciousness is provided by administration of local ..
  28. Prostaglandin E2 Signaling in Growth and Pains of Endometriosis
    Joe A Arosh; Fiscal Year: 2012
    ..PGE2 produced at the site of inflammation acts on the nociceptors of peripheral terminals through EP1, EP2, EP3, and EP4 receptors by integrating multiple cell signaling ..
  29. The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial I
    ISAAC MING CHENG CHIU; Fiscal Year: 2012
    ..Pain is a major symptom of patients suffering from infectious diseases. During tissue inflammation, nociceptors, the neurons which react to intense/damaging stimuli, are excited, leading to a state of hyper-algesia...
  30. Peripheral and Central Mechanisms of Fatigue and Pain in Patients with ME/CFS
    Roland Staud; Fiscal Year: 2013
    ..metabolites results in stimulation of ERGOreceptors (ERGO) (afferents sensitive to muscle metabolites) and nociceptors in muscles with resulting autonomic nervous system (ANS), HPAaxis, fatigue, and pain pathway activation...
  31. Identification of transcriptional determinants of dendritic patterning
    David M Miller; Fiscal Year: 2010
    ..Pain is perceived by specialized sensory neurons called nociceptors that utilize elaborate webs of dendritic processes to detect harmful stimuli...
  32. N-type Calcium Channels in Nociceptive Neurons
    Diane Lipscombe; Fiscal Year: 2013
    ..This is important because i) we previously showed that CaV2.2-e37a channels are enriched in nociceptors whereas CaV2...
  33. Activation of the Trigeminovascular Pathway
    Rami Burstein; Fiscal Year: 2011
    ..aura is driven by cortical spreading depression (CSD), whereas migraine headache by activation of meningeal nociceptors. In this grant proposal, we aim at gaining insights into novel mechanisms by which CSD may lead to the ..
  34. Molecular and spatial mapping of bladder nociceptors during development and matur
    Adam Wallace; Fiscal Year: 2013
    ..RNA to be sequenced and characterized, building a molecular map of the development and maturation of these nociceptors. By applying the latest bioinformatics analyses this will (i) identify transcripts uniqe to DRG that contain ..
  35. Analgesics Targeting TRPA1 for Treatment of Chronic Pain
    JEFF MARK HERZ; Fiscal Year: 2011
    ..Since TRPA1 is one of the most important signal integrators for pain in sensory nociceptors, targeting TRPA1 is a logical approach to block nociceptive signals at the first stage of neural processing...
  36. Mechanisms of Muscle Afferent Sensitization after Ischemia
    Michael P Jankowski; Fiscal Year: 2013
    ..While much is known about the functional properties and plasticity of cutaneous nociceptors following peripheral injuries and how these fibers contribute to pain, relatively little is known about the ..
  37. Control of Arthritic Pain by Inhibition of TRPA1 Activity
    JEFF MARK HERZ; Fiscal Year: 2013
    ..Since TRPA1 is one of the most important signal integrators for pain in sensory nociceptors in the joint, an antagonist of TRPA1 will function as a peripherally acting analgesic...
  38. Osteoarthritis Progression And Sensory Pathway Alterations
    Richard J Miller; Fiscal Year: 2013
    ..technology to transiently silence all sensory DRG neurons (using the pan-DRG Advillin promoter) or a subset of nociceptors (using Nav1.8 promoter)...
  39. Elucidating the Role of Type II Afferent Neurons in Auditory Nociception
    EMMA NOEMI FLORES; Fiscal Year: 2013
    ..Type II afferents share anatomical similarities with somatosensory nociceptors that detect damaging stimuli throughout the body...
  40. CHEMOSENSORY TRANSDUCTION IN TASTE CELLS
    Stephen D Roper; Fiscal Year: 2012
    ..Although much is known about how extracellular protons stimulate nociceptors, little attention to date has been paid to intracellular acidification, even though this likely occurs during ..
  41. Multiple Opioid Receptors and the Control of Pain
    Allan I Basbaum; Fiscal Year: 2013
    ..and the MOR are expressed in non-overlapping subsets of dorsal root ganglia (DRG) "pain" transmission neurons (nociceptors) and regulate distinct pain modalities...
  42. Toxins as molecular probes of pain transduction mechanisms
    JEREMIAH OSTEEN; Fiscal Year: 2013
    ..ion channels (ASICs) are expressed in a subset of primary afferent nerve fibers which mediate pain signals (nociceptors) and these channels are candidates as transducers of acidosis-triggered pain responses...
  43. TRP and AQP Channels: Modulation of Function, Raft Location by Membrane Lipids
    THOMAS J MC INTOSH; Fiscal Year: 2012
    The Transient Receptor Potential Vanilloid 1 channel (TRPV1) is a key component of nociceptors and is also a mechanosensor in the urinary bladder and osmosensor in neurons...
  44. ASIC Channels and Pain
    David Julius; Fiscal Year: 2013
    ..Indeed, extracellular protons enhance excitability of primary afferent nociceptors, thereby producing acute pain and/or pain hypersensitivity...
  45. Estrogen and Psychological Stress in TMJD Pain
    David A Bereiter; Fiscal Year: 2013
    ..subnucleus caudalis/upper cervical dorsal horn region (Vc/C1-2), the principal site of termination for TMJ nociceptors. Masseter muscle electromyographic (EMG) activity will allow us to assess treatment effects on a peripheral ..
  46. BRAINSTEM CONTROL OF PAIN TRANSMISSION
    Allan I Basbaum; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Molecular analyses of primary afferent nociceptors have revealed remarkable heterogeneity...
  47. Serotonin Modulation of Trigeminal Nociceptors
    DAYNA RUTH LOYD; Fiscal Year: 2010
    ..5HT) receptors and overall integrated actions of 5HT on rat and human trigeminal capsaicin- sensitive nociceptors (craniofacial pain transmitting sensory neurons)...
  48. Group III mGLURs: Mechanisms of Analgesia
    Susan M Carlton; Fiscal Year: 2013
    ..Group III produces the same inhibitory modulation in the periphery, selective activation of Group III mGluRs on nociceptors may provide powerful and long lasting depression of noxious input...
  49. Anatomy and Function of TRPM8 and TRPA1 in Nociceptors of Dental Pulp
    JENNIFER LYNN GIBBS; Fiscal Year: 2013
    ..Further, these studies will contribute to our understanding of the neurobiology of receptors involved in cold nociception. ..
  50. Sodium Channels in Spinal Cord Injury, Nerve Injury and Neuropathic Pain
    Stephen Waxman; Fiscal Year: 2013
    ..Preferential expression of several Na channel isoforms in DGR neurons including nociceptors, and the up-regulation after nerve injury of another isoform, which is not present at high levels within the ..
  51. Peripheral activation of Group III mGluR potentiates morphine analgesia
    ALYSSA LANE BAKER; Fiscal Year: 2013
    ..pain transmission at the spinal cord level, but it is unknown if Group III agonists directly inhibit peripheral nociceptors. Spinal or systemic administration of Group III agonists potentiates morphine analgesia in nerve injury, but ..
  52. Neurotrophin signals controlling development of the peripheral nervous system
    David D Ginty; Fiscal Year: 2013
    ..the sensory neuron-subtype specific transcription factor Runx1 to instruct differentiation of non-peptidergic nociceptors. Thus, proposed work will provide insight into how the target field, and target-derived NGF, controls ..
  53. Nociceptive Mechanisms Underlying Sickle Cell Pain
    CHERYL LOUISE STUCKY; Fiscal Year: 2012
    ..preparations from these mice indicate that both myelinated A[unreadable] fiber and unmyelinated C fiber nociceptors are sensitized to mechanical stimuli...
  54. Nociception from Deep Muscle Incision
    TIMOTHY JOHN BRENNAN; Fiscal Year: 2012
    ..Skin incision will not affect these behaviors. 2. Demonstrate activation and sensitization of primary afferent nociceptors by deep muscle incision but not by skin incision...
  55. Axonal translation as a novel mechanism of nociceptor plasticity
    Theodore J Price; Fiscal Year: 2013
    ..We hypothesize that algogenic compounds engage signaling to the translational machinery in nociceptors and their axons to enhance the efficiency of the rate-limiting step of translation, elongation initiation...
  56. Purinergic G protein signal integration in nociceptors
    Derek C Molliver; Fiscal Year: 2013
    ....
  57. Molecular Pain Mechanisms
    Gerard P Ahern; Fiscal Year: 2010
    ..We hypothesize that polycations and cationic peptides can regulate the excitability of nociceptors through the modulation of TRPV1...
  58. Neuromodulation of Kv3.4 channels in nociceptors
    MANUEL L COVARRUBIAS; Fiscal Year: 2013
    ..clear how this change contributes to disease because the specific roles and modulation of A-type K+ channels in nociceptors are not understood. The A-type high voltage-activated Kv3...
  59. Nociceptor Maturation and Response to Peripheral Injury
    CHARLES JEFFERY WOODBURY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Pain sensory neurons, or nociceptors, are particularly vulnerable to tissue trauma and inflammation during early life, and there is mounting evidence that peripheral inflammation in newborns can lead ..
  60. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    Although sympathetic fibers are thought to activate peripheral nociceptors in certain chronic injury syndromes, relatively little is known about sympathetic modulation of capsaicin-sensitive fibers under control conditions...
  61. Endothelin mechanisms in metastic prostate cancer pain
    Gary R Strichartz; Fiscal Year: 2013
    ..To determine the mechanism for the rapid increase in TRPV1 in epidermal nociceptors following injection of ET-1 and local inflammation. 2...
  62. Endothelin mechanisms in metastic prostate cancer pain
    Gary Strichartz; Fiscal Year: 2009
    ..To determine the mechanism for the rapid increase in TRPV1 in epidermal nociceptors following injection of ET-1 and local inflammation. 2...
  63. Temperature-Dependent Gating of Vanilloid Receptors
    Feng Qin; Fiscal Year: 2013
    ..are attractive ion-channel targets for the development of novel analgesic drugs that could act peripherally at nociceptors where pain is generated...
  64. Sensory Plasticity During Central Neuropathic Pain Caused by Spinal Cord Injury
    Edgar T Walters; Fiscal Year: 2010
    ..attention is an enhancement of spontaneous activity (SA) and excitability in the sensory neurons (especially nociceptors) that normally excite dorsal horn neurons...
  65. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2009
    ..We areparticularly interested in identifying the chemical mediators which sensitize bladder, nociceptors and how these chemical mediators alter ion channels in afferent neurons and thereby change afferent receptor ..
  66. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..central antinociceptive actions, also act in the periphery to modulate the activity of terminals of certain nociceptors. Such peripheral actions of cannabinoids would be physiologically and clinically significant, since inhibition ..
  67. Non-Peptide Somatostatin Agonist Analgesics
    Susan Carlton; Fiscal Year: 2007
    ..SSTR activation prevents nociceptor sensitization and provides phasic and tonic inhibitory control of nociceptors. This modulation is an important therapeutic goal since sensitization of peripheral nociceptors in inflammation ..
  68. Estrogen Withdrawal and Dural Mast Cells: Implication for Menstrual Migraine
    Dan Levy; Fiscal Year: 2010
    ..that changes in the level of reproductive hormones exert a modulatory influence on the activity of meningeal nociceptors and specifically, that estrogen withdrawal produces an increase in meningeal nociceptor sensitivity to migraine ..
  69. MECHANISMS OF ACTIVATION OF CARDIAC NOCICEPTORS
    Hui Lin Pan; Fiscal Year: 2005
    ..However, the mechanisms of activation of cardiac nociceptors are not fully understood...
  70. Cytokine pathways and orofacial pain
    Ke Ren; Fiscal Year: 2006
    ..beta (IL-l beta) are released at the site of injury and contribute to an increased sensitivity of peripheral nociceptors. Importantly, the involvement of cytokines in persistent pain does not appear to be limited to peripheral ..
  71. Mast Cells: Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2007
    ..Given the ability of mast cells to release an abundance of algesic mediators and their proximity to nociceptors, a functional relationship is suggested...
  72. PERIPHERAL & CENTRAL SUBSTRATES OF PRIMARY HYPERALGESIA
    Alan Randich; Fiscal Year: 2000
    ..recordings of low threshold mechanoreceptors (LTMs), high threshold mechanoreceptors (HTMs), A-mechanoheat nociceptors (AMHs), C-polymodal nociceptors (CPMs), and C-mechanonociceptors (CMNs), (2) determine how mechanical and ..
  73. CONTROL OF NEURAL FUNCTION IN ANESTHESIA
    Gary Strichartz; Fiscal Year: 2001
    ..There are three hypotheses: A. Afferent impulses in both non-myelinated C "nociceptors" and myelinated mechanosensitive fibers are necessary to elicit withdrawal responses to noxious stimuli; B...
  74. NOCICEPTORS AND GLUTAMATE RECEPTORS
    AMY MACDERMOTT; Fiscal Year: 2003
    DESCRIPTION (adapted from applicant's abstract): Cutaneous nociceptors are a heterogeneous group of peripheral sensory neurons that sense noxious, damage-causing stimuli in the periphery and transmit that signal to the central nervous ..