muscle spindles

Summary

Summary: Mechanoreceptors found between skeletal muscle fibers. Muscle spindles are arranged in parallel with muscle fibers and respond to the passive stretch of the muscle, but cease to discharge if the muscle contracts isotonically, thus signaling muscle length. The muscle spindles are the receptors responsible for the stretch or myotactic reflex (REFLEX, STRETCH).

Top Publications

  1. ncbi A role for neuregulin1 signaling in muscle spindle differentiation
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056, Basel, Switzerland
    Neuron 36:1035-49. 2002
  2. ncbi ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
    S Arber
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 101:485-98. 2000
  3. pmc Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles
    Anna Simon
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Physiol 588:171-85. 2010
  4. pmc An allometric analysis of the number of muscle spindles in mammalian skeletal muscles
    R W Banks
    School of Biological and Biomedical Sciences, University of Durham, UK
    J Anat 208:753-68. 2006
  5. ncbi Human muscle spindles act as forward sensory models
    Michael Dimitriou
    Computational and Biological Learning Laboratory, Department of Engineering, University of Cambridge, CB2 1PZ, UK
    Curr Biol 20:1763-7. 2010
  6. ncbi Development of the monosynaptic stretch reflex circuit
    Hsiao Huei Chen
    Department of Neurobiology, University of Pittsburgh Medical School, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Curr Opin Neurobiol 13:96-102. 2003
  7. pmc ErbB2 is required for muscle spindle and myoblast cell survival
    Eran R Andrechek
    Institute for Molecular Biology and Biotechnology, Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Cell Biol 22:4714-22. 2002
  8. ncbi The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
    Thomas W Gould
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 28:2131-46. 2008
  9. ncbi Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development
    Marco Leu
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstr 66, 4058 Basel, Switzerland
    Development 130:2291-301. 2003
  10. pmc Sensory protection of rat muscle spindles following peripheral nerve injury and reinnervation
    Amal Elsohemy
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Plast Reconstr Surg 124:1860-8. 2009

Research Grants

Detail Information

Publications238 found, 100 shown here

  1. ncbi A role for neuregulin1 signaling in muscle spindle differentiation
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056, Basel, Switzerland
    Neuron 36:1035-49. 2002
    ..One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early ..
  2. ncbi ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
    S Arber
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 101:485-98. 2000
    ..Er81 mutant mice exhibit a severe motor discoordination, yet the specification of MNs and induction of muscle spindles occurs normally...
  3. pmc Amiloride-sensitive channels are a major contributor to mechanotransduction in mammalian muscle spindles
    Anna Simon
    School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    J Physiol 588:171-85. 2010
    ..are a major contributor to mechanosensory transduction in primary mechanosensory afferents, using adult rat muscle spindles as a model system...
  4. pmc An allometric analysis of the number of muscle spindles in mammalian skeletal muscles
    R W Banks
    School of Biological and Biomedical Sciences, University of Durham, UK
    J Anat 208:753-68. 2006
    An allometric analysis of the number of muscle spindles in relation to muscle mass in mammalian (mouse, rat, guinea-pig, cat, human) skeletal muscles is presented...
  5. ncbi Human muscle spindles act as forward sensory models
    Michael Dimitriou
    Computational and Biological Learning Laboratory, Department of Engineering, University of Cambridge, CB2 1PZ, UK
    Curr Biol 20:1763-7. 2010
    ..We therefore conclude that muscle spindles can act as "forward sensory models": they are affected both by the current state of their parent muscle and ..
  6. ncbi Development of the monosynaptic stretch reflex circuit
    Hsiao Huei Chen
    Department of Neurobiology, University of Pittsburgh Medical School, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    Curr Opin Neurobiol 13:96-102. 2003
    ..Finally, neurotrophin 3 released from muscle spindles regulates the strength of sensory-motor connections within the spinal cord postnatally.
  7. pmc ErbB2 is required for muscle spindle and myoblast cell survival
    Eran R Andrechek
    Institute for Molecular Biology and Biotechnology, Department of Biology, McMaster University, Hamilton, Ontario, Canada
    Mol Cell Biol 22:4714-22. 2002
    ..This resulted in viable mice with a progressive defect in proprioception due to loss of muscle spindles. Interestingly, a partial reduction of ErbB2 levels also reduced the number of muscle spindles...
  8. ncbi The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes
    Thomas W Gould
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    J Neurosci 28:2131-46. 2008
    ..Whereas nearly all hindlimb muscles exhibited normal gross innervation, intrafusal muscle spindles displayed a significant loss of innervation in most but not all muscles at P0...
  9. ncbi Erbb2 regulates neuromuscular synapse formation and is essential for muscle spindle development
    Marco Leu
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstr 66, 4058 Basel, Switzerland
    Development 130:2291-301. 2003
    ..However, functional spindles never develop. Taken together, our data suggest that Erbb2 signaling regulates the formation of both neuromuscular synapses and muscle spindles.
  10. pmc Sensory protection of rat muscle spindles following peripheral nerve injury and reinnervation
    Amal Elsohemy
    Department of Psychiatry and Behavioral Neurosciences, McMaster University, Hamilton, Ontario, Canada
    Plast Reconstr Surg 124:1860-8. 2009
    ..denervation results in irreversible muscle fiber atrophy, connective tissue hyperplasia, and deterioration of muscle spindles, specialized sensory receptors necessary for proper skeletal muscle function...
  11. ncbi Effects of tail suspension on electrophysiological characteristics of muscle spindles in isolated rat soleus muscle
    Bin Tang
    Department of Physiology, Medical School of Xi an Jiatong University, Xi an
    Space Med Med Eng (Beijing) 17:1-6. 2004
    To study changes in electrophysiological characteristics of muscle spindles induced by simulated weightlessness in isolated rats soleus.
  12. ncbi Somatic and intramuscular distribution of muscle spindles and their relation to muscular angiotypes
    Theodoros Kokkorogiannis
    Laboratory of Physiology, School of Health Professions, TEI of Athens, Agiou Spyridonos, 12210 Aigaleo, Athens, Greece
    J Theor Biol 229:263-80. 2004
    The distribution pattern of muscle spindles in the skeletal musculature has been reviewed in a large number of muscles (using the literature data especially from cat and man), and the relation of spindle content to muscle mass was ..
  13. ncbi Formation of supernumerary muscle spindles at the expense of Golgi tendon organs in ER81-deficient mice
    J Kucera
    Department of Neurology, Boston University, 80 East Concord Street, Boston, MA 02118, USA
    Dev Dyn 223:389-401. 2002
    ..potentials than stimulation of distal nerves in hindlimbs, a deficit that is paralleled by a paucity of muscle spindles in proximal muscles (Arber et al., 2000)...
  14. ncbi Immunohistochemical characterization of capsular cells in neuromuscular spindles of the neck
    Asterios Triantafyllou
    Oral Pathology, Department and School of Dental Studies, The University of Liverpool, Liverpool, UK
    J Oral Pathol Med 36:501-4. 2007
    ..To identify capsular components of neuromuscular spindles in man by means of immunohistochemistry...
  15. ncbi On muscle spindles, dystonia and botulinum toxin
    R L Rosales
    Department of Neurology and Psychiatry, University of Santo Tomas, Sampaloc, Metro Manila, Philippines
    Eur J Neurol 17:71-80. 2010
    Dystonia may produce co-contractions and constant strain in numerous muscle fibers, including those of the muscle spindles. As proprioceptors, muscle spindles detect dynamic or static changes in muscle length and their afferent ..
  16. ncbi Stretch reflexes in human abdominal muscles
    I D Beith
    Centre for Applied Biomedical Research and Physiotherapy Division, King s College London, Shepherd s House, Guy s Campus, London, SE1 1UL, UK
    Exp Brain Res 159:206-13. 2004
    ..It follows that if the homonymous stretch reflex of abdominal muscles have a monosynaptic component, then a similar monosynaptic pathway activates synergistic motoneurones, not only ipsilaterally but also contralaterally...
  17. ncbi Neuregulin1 signaling targets SRF and CREB and activates the muscle spindle-specific gene Egr3 through a composite SRF-CREB-binding site
    Carter A Herndon
    Indiana University School of Medicine Muncie and Ball State University, 2000 University Avenue, Muncie, IN 47306, USA
    Exp Cell Res 319:718-30. 2013
    b>Muscle spindles are sensory receptors embedded within muscle that detect changes in muscle length...
  18. ncbi Myosin heavy chain composition of muscle spindles in human biceps brachii
    Jing Xia Liu
    Department of Integrative Medical Biology, Section of Anatomy, Umea, Sweden
    J Histochem Cytochem 50:171-83. 2002
    Data on the myosin heavy chain (MyHC) composition of human muscle spindles are scarce in spite of the well-known correlation between MyHC composition and functional properties of skeletal muscle fibers...
  19. pmc Age-related physiological and morphological changes of muscle spindles in rats
    Gee Hee Kim
    Graduate School of Human Sciences, Waseda University, Tokorozawa, 359 1192, Japan
    J Physiol 582:525-38. 2007
    Age-related physiological and morphological changes of muscle spindles were examined in rats (male Fischer 344/DuCrj: young, 4-13 months; middle-aged, 20-22 months; old, 28-31 months)...
  20. ncbi Sensory ataxia and muscle spindle agenesis in mice lacking the transcription factor Egr3
    W G Tourtellotte
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 20:87-91. 1998
    b>Muscle spindles are skeletal muscle sensory organs that provide axial and limb position information (proprioception) to the central nervous system...
  21. ncbi Vibration sensitivity of human muscle spindles and Golgi tendon organs
    James B Fallon
    Prince of Wales Medical Research Institute, Sydney, NSW, Australia
    Muscle Nerve 36:21-9. 2007
    ....
  22. ncbi The transcription factor Egr3 modulates sensory axon-myotube interactions during muscle spindle morphogenesis
    W G Tourtellotte
    Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois 60611, USA
    Dev Biol 232:388-99. 2001
    ..We conclude that Egr3 has an essential role in regulating genes required for the transformation of undifferentiated myotubes into intrafusal fibers, and hence for the phenotypic differentiation of spindles...
  23. ncbi Effects of changes in pH on the afferent impulse activity of isolated cat muscle spindles
    M Fischer
    Department of Neurophysiology, Abteilung Neurophysiologie OE 4230 Medizinische Hochschule, Hannover Medical School, Carl Neuberg Str 1, D 30625 Hannover, Germany
    Brain Res 1043:163-78. 2005
    ..H(+), lactate and CO(2) might also affect the receptor in the fatiguing muscle, the impulse activity of muscle spindles isolated from the cat tenuissimus muscle was characterized under varying degrees of extracellular pH, thus ..
  24. ncbi Immunohistochemical localization of alpha(1a)-adrenoreceptors in muscle spindles of rabbit masseter muscle
    C Bombardi
    Department of Veterinary Morphophysiology and Animal Productions, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano dell Emilia, Italy
    Tissue Cell 38:121-5. 2006
    The expression of alpha(1a)-adrenoreceptors (alpha(1a)-ARs) within the muscle spindles of rabbit masseter muscle was investigated...
  25. ncbi Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons
    Hsiao Huei Chen
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 22:3512-9. 2002
    Ia afferents induce the formation of muscle spindles prenatally and maintain them postnatally...
  26. ncbi Position sensitivity of human muscle spindles: single afferent and population representations
    Paul J Cordo
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    J Neurophysiol 87:1186-95. 2002
    ....
  27. ncbi Immunolocalization of GQ1b and related gangliosides in human extraocular neuromuscular junctions and muscle spindles
    Jing Xia Liu
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    Invest Ophthalmol Vis Sci 50:3226-32. 2009
    ..anti-GQ1b, -GT1a, and -GD1b antibody binding in human extraocular muscles (EOMs), axial and limb muscles, and muscle spindles and thereby test the hypothesis that their distinctive ganglioside composition provides the molecular basis ..
  28. ncbi Response of muscle proprioceptors to spinal manipulative-like loads in the anesthetized cat
    J G Pickar
    Kansas State University, Department of Anatomy and Physiology, Manhattan, KS, USA
    J Manipulative Physiol Ther 24:2-11. 2001
    ..The purpose of the present study was to determine whether muscle spindles and Golgi tendon organs in paraspinal muscles respond to a mechanical load whose force-time profile is ..
  29. pmc Two novel/ancient myosins in mammalian skeletal muscles: MYH14/7b and MYH15 are expressed in extraocular muscles and muscle spindles
    Alberto C Rossi
    Department of Biomedical Sciences, University of Padova, Padova, Italy
    J Physiol 588:353-64. 2010
    ..only in a minor fibre population in EO muscles, corresponding to slow-tonic fibres, and in bag fibres of muscle spindles. MYH15 protein is present in most fibres of the orbital layer of EO muscles and in the extracapsular region ..
  30. ncbi Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development
    Jennifer Whitehead
    Department of Pathology Neuropathology, Northwestern University, Chicago, IL 60611, USA
    Mech Dev 122:27-41. 2005
    ..was decreased, whereas in transgenic mice that overexpress GDNF in muscle, fusimotor innervation to muscle spindles was increased...
  31. pmc Gamma and alpha motor neurons distinguished by expression of transcription factor Err3
    Andreas Friese
    Biozentrum, Department of Cell Biology, University of Basel and Friedrich Miescher Institute for Biomedical Research, CH 4058 Basel, Switzerland
    Proc Natl Acad Sci U S A 106:13588-93. 2009
    ..Signals from muscle spindles are needed to support the differentiation of Err3(on)/NeuN(off) presumptive gamma motor neurons, whereas ..
  32. ncbi Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice
    Karra A Muller
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Diabetes 57:1693-701. 2008
    ..Large sensory axons innervating muscle spindles provide feedback for balance and gait and, when damaged, can cause altered sensorimotor function...
  33. ncbi Muscle spindles in the paraspinal musculature of patients with adolescent idiopathic scoliosis
    D M Ford
    Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada
    Spine (Phila Pa 1976) 13:461-5. 1988
    ..This project consisted of a detailed histologic and histochemical analysis of the distribution of muscle spindles in paraspinal musculature of patients suffering from idiopathic scoliosis, using the reduced form of ..
  34. ncbi Stimulation of chemosensitive afferents from multifidus muscle does not sensitize multifidus muscle spindles to vertebral loads in the lumbar spine of the cat
    Y M Kang
    Palmer Center for Chiropractic Research, Davenport
    Spine (Phila Pa 1976) 26:1528-36. 2001
    ..and IV muscle afferents sensitive to algesic or inflammatory metabolites increases the stretch sensitivity of muscle spindles via a reflex pathway involving gamma-motoneurons...
  35. ncbi Muscle spindles in the deep muscles of the human neck: a morphological and immunocytochemical study
    Jing Xia Liu
    Department of Integrative Medical Biology, Section of Anatomy, Umea University, Sweden
    J Histochem Cytochem 51:175-86. 2003
    ..However, there is a paucity of information regarding the morphology and immunoreactivity of these muscle spindles. The objective of this study was to investigate the intrafusal fiber content and to assess the myosin heavy ..
  36. ncbi Target-induced transcriptional control of dendritic patterning and connectivity in motor neurons by the ETS gene Pea3
    Eline Vrieseling
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Cell 127:1439-52. 2006
    ..These findings suggest that target-induced transcriptional programs control MN dendrite orientation and play a crucial role in the establishment of sensory-motor connections in the spinal cord...
  37. ncbi Muscle spindle activity following muscle tendon vibration in man
    E Ribot-Ciscar
    Laboratoire de Neurobiologie Humaine, UMR CNRS 6562, 52 Faculté des Sciences de St Jérome, Marseille, France
    Neurosci Lett 258:147-50. 1998
    ..The results are discussed in the light of previous psychophysiological studies reporting an altered position sense and a development of involuntary muscle contractions in postvibratory periods...
  38. pmc A comparative analysis of the encapsulated end-organs of mammalian skeletal muscles and of their sensory nerve endings
    R W Banks
    University of Durham, UK
    J Anat 214:859-87. 2009
    ..the existence of a gradual proximo-distal decline in the overall average size of the afferent complement of muscle spindles from axial through hind limb to intrinsic foot muscles, but with considerable muscle-specific variability...
  39. ncbi Increased intra-articular concentration of bradykinin in the temporomandibular joint changes the sensitivity of muscle spindles in dorsal neck muscles in the cat
    Fredrik Hellström
    Centre for Musculoskeletal Research, National Institute for Working Life, Box 7654, S 907 13 Umeå, Sweden
    Neurosci Res 42:91-9. 2002
    ..of bradykinin-sensitive nerve endings of the temporomandibular joint (TMJ) might induce changes in the muscle spindles output from neck muscles through reflex effects on cervical fusimotor neurones...
  40. ncbi Differential sensitivity of skeletal and fusimotor neurons to Bcl-2-mediated apoptosis during neuromuscular development
    K Hui
    Graduate Department of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, Ontario, Canada
    Cell Death Differ 15:691-9. 2008
    ..These results demonstrate, for the first time, the connection between Bcl-2 expression, motor neuron survival, and the establishment of different motor populations...
  41. ncbi Muscle spindles are multi-functional
    Uwe Windhorst
    Center for Physiology and Pathophysiology, University of Goettingen, Humboldtallee 23, Goettingen, Germany
    Brain Res Bull 75:507-8. 2008
    The number and distribution of mammalian muscle spindles in their parent muscle are not simply related to overall muscle length because (i) they lie in parallel to muscle-fibers in series to elastic elements; (ii) muscle architectures ..
  42. ncbi Fiber content and myosin heavy chain composition of muscle spindles in aged human biceps brachii
    Jing Xia Liu
    Department of Integrative Medical Biology, Section for Anatomy, Umea University, Umea, Sweden
    J Histochem Cytochem 53:445-54. 2005
    The present study investigated potential age-related changes in human muscle spindles with respect to the intrafusal fiber-type content and myosin heavy chain (MyHC) composition in biceps brachii muscle...
  43. pmc Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3
    Neil A Shneider
    Section on Developmental Neurobiology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 29:4719-35. 2009
    ..muscle spindle afferents and spinal motor neurons are believed to be regulated by factors originating from muscle spindles. Here, we find that the connections form with appropriate specificity in mice with abnormal spindle ..
  44. ncbi Muscle spindles in the levator palpebrae superioris muscle of human foetuses
    Ewa Korzeniowska-Kromer
    Department of Anatomy, University of Medical Sciences, Poznan, Poland
    Folia Morphol (Warsz) 62:289-90. 2003
    ..The number of muscle spindles varied from 2 in the 17th week to 7 in the 30th week...
  45. ncbi Quantitative study of muscle spindles in suboccipital muscles of human foetuses
    V Kulkarni
    Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, India
    Neurol India 49:355-9. 2001
    ..The density, distribution and morphology of muscle spindles were studied in superior oblique capitis, inferior oblique capitis and rectus capitis posterior major and ..
  46. pmc The mechanism of the force response to stretch in human skinned muscle fibres with different myosin isoforms
    Marco Linari
    Laboratorio di Fisiologia, Viale GB Morgagni, 63 50134 Firenze, Italy
    J Physiol 554:335-52. 2004
    ....
  47. ncbi The bilateral reflex control of the trapezius muscle in humans
    C M Alexander
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Exp Brain Res 142:418-24. 2002
    ..These results imply that muscle spindle afferents from the ipsilateral trapezius monosynaptically activate motoneurones contralaterally...
  48. ncbi Modulation of muscle spindle innervation by neurotrophin-3 following nerve injury
    Michael D Taylor
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Exp Neurol 191:211-22. 2005
    b>Muscle spindles monitor changes in muscle length and are innervated by groups Ia and II sensory axons as well as gamma motor axons...
  49. pmc Resting discharge of human muscle spindles is not modulated by increases in sympathetic drive
    Vaughan G Macefield
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    J Physiol 551:1005-11. 2003
    There is evidence in experimental animals that, in addition to receiving fusimotor drive, muscle spindles are subject to modulation by the sympathetic nervous system...
  50. ncbi Movement reduces the dynamic response of muscle spindle afferents and motoneuron synaptic potentials in rat
    Valerie K Haftel
    Department of Physiology, Emory University, Atlanta, Georgia 30322, USA
    J Neurophysiol 91:2164-71. 2004
    ..of muscle contraction is the history dependence observed under some conditions in the response properties of muscle spindles. The present study was designed to test one report that in successive trials of muscle stretch-release, ..
  51. pmc Neuregulin induces the expression of transcription factors and myosin heavy chains typical of muscle spindles in cultured human muscle
    Christian Jacobson
    Microarray Unit, Genetics and Genomics Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:12218-23. 2004
    ..Taken together, these results indicate that not only can NRG induce the expression of a transcription factor key to spindle fiber development (Egr3), but that a portion of this developmental process can be replicated in vitro...
  52. ncbi The role of paraspinal muscle spindles in lumbosacral position sense in individuals with and without low back pain
    S Brumagne
    Department of Rehabilitation Sciences, Faculty of Physical Education and Physiotherapy, Katholieke Universiteit Leuven, Leuven, Belgium
    Spine (Phila Pa 1976) 25:989-94. 2000
    ..A two-group experimental design with repeated measures on one factor was used...
  53. ncbi Aging affects passive stiffness and spindle function of the rat soleus muscle
    Cedric Rosant
    UMR CNRS 6600 Biomécanique et Génie Biomédical, Universite de Technologie de Compiegne, BP 20529, F 60205 Compiègne Cedex, France
    Exp Gerontol 42:301-8. 2007
    ..The contralateral muscle was used to count muscle spindles and spindle fibers (ATPase staining) and immunostained to identify MyHC isoforms...
  54. ncbi Phylogenetic preservation of alpha3 Na+,K+-ATPase distribution in vertebrate peripheral nervous systems
    Dmitry Romanovsky
    Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Comp Neurol 500:1106-16. 2007
    The alpha(3) isoform of Na(+),K(+)-ATPase is uniquely expressed in afferent and efferent neurons innervating muscle spindles in the peripheral nervous system (PNS) of adult rats, but the distribution pattern of this isoform in other ..
  55. ncbi Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    J Comp Neurol 511:92-108. 2008
    ..was observed in TrkC-positive nerve fibers around neurotrophin 3 (NT3)-positive intrafusal muscle fibers of muscle spindles at E17.5...
  56. ncbi Histochemical and immunohistochemical study on muscle fibers in human extraocular muscle spindles
    Waltraut Wicke
    Medical University of Vienna, Center of Anatomy and Cell Biology, Integrative Morphology Group, Waehringer Stasse 13, 1090 Vienna, and Institute of Pathology and Bacteriology, Kaiserin Elisabeth Hospital, Austria
    Exp Eye Res 84:670-9. 2007
    ..Sixteen muscle spindles in human extraocular muscles counted as 'true' spindles revealed 27% nuclear chain fibers [40.1 microm+/-10...
  57. ncbi Hypoglossal nucleus projections to the rat masseter muscle
    O Mameli
    Department of Biomedical Sciences, Human Physiology Division, University of Sassari, 07100 Sassari, Italy
    Brain Res 1283:34-40. 2009
    ..also spread into the masseter branch of the trigeminal nerve to target the polar portions of the masseter muscle spindles. Retrograde double labelling, performed by injecting Dil into the pad and True Blue into the ipsilateral ..
  58. ncbi Effects on the fusimotor-muscle spindle system induced by intramuscular injections of hypertonic saline
    Johan Thunberg
    Department of Surgery and Perioperative Sciences, Division of Sports Medicine, Umea University, Sweden
    Exp Brain Res 142:319-26. 2002
    ..Predominantly static fusimotor neurones were activated. The possible role of the fusimotor-muscle spindle system in altered motor control during experimentally induced muscle pain is discussed...
  59. pmc The role of muscle spindles in the development of the monosynaptic stretch reflex
    Zhi Wang
    Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA
    J Neurophysiol 108:83-90. 2012
    Muscle sensory axons induce the development of specialized intrafusal muscle fibers in muscle spindles during development, but the role that the intrafusal fibers may play in the development of the central projections of these Ia sensory ..
  60. ncbi Characterization of spindle afferents in rat soleus muscle using ramp-and-hold and sinusoidal stretches
    Laurent De-Doncker
    Laboratoire de Plasticite Neuromusculaire, EA 1032, IFR 118, Bat SN4, Université des Sciences et Technologies de Lille 1, F 59655 Villeneuve d Ascq Cedex, France
    J Neurophysiol 89:442-9. 2003
    The discharge properties of 51 afferents were studied in the rat soleus muscle spindles. Under deep anesthesia using a pentobarbital sodium solution (30 mg/kg), a laminectomy was performed and the right L(4) and L(5) dorsal and ventral ..
  61. pmc Position sensitivity of feline paraspinal muscle spindles to vertebral movement in the lumbar spine
    Dong Yuan Cao
    Palmer Center for Chiropractic Research, 741 Brady St, Davenport, IA 52803, USA
    J Neurophysiol 101:1722-9. 2009
    b>Muscle spindles contribute to sensorimotor control by supplying feedback regarding muscle length and consequently information about joint position...
  62. pmc The effects of experimental muscle and skin pain on the static stretch sensitivity of human muscle spindles in relaxed leg muscles
    Ingvars Birznieks
    Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW 2031, Sydney, Australia
    J Physiol 586:2713-23. 2008
    Animal studies have shown that noxious inputs onto gamma-motoneurons can cause an increase in the activity of muscle spindles, and it has been proposed that this causes a fusimotor-driven increase in muscle stiffness that is believed to ..
  63. ncbi Age-related changes and the possible adaptability of rat jaw muscle spindles: immunohistochemical and fine structural studies
    Ladda Winarakwong
    Orthodontic Science, Department of Orofacial Development and Function, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Arch Histol Cytol 67:227-40. 2004
    Afferent signals from jaw muscle spindles contribute to the feedback mechanism that regulates mastication...
  64. pmc Activation dependence of stretch activation in mouse skinned myocardium: implications for ventricular function
    Julian E Stelzer
    Department of Physiology, University of Wisconsin Medical School, Madison, WI 53706, USA
    J Gen Physiol 127:95-107. 2006
    ..Such a mechanism would contribute to increased systolic ejection in response to increased delivery of activator Ca2+ during excitation-contraction coupling...
  65. ncbi Ago-antagonist muscle spindle inputs contribute together to joint movement coding in man
    E Ribot-Ciscar
    Laboratoire de Neurobiologie Humaine, UMR CNRS 6562 Université de Provence, Marseille, France
    Brain Res 791:167-76. 1998
    ..All in all, joint movement perception seems to result from the co-processing by the central nervous system of the multiple spindle feedbacks originating from the whole set of muscles involved in the performance of a movement...
  66. pmc Contribution of spindle reflexes to post-inspiratory activity in the canine external intercostal muscles
    S V Berdah
    Laboratory of Cardiorespiratory Physiology, Brussels School of Medicine, 1070 Brussels, Belgium
    J Physiol 534:873-80. 2001
    ..post-inspiratory activity than the parasternal intercostal muscles and are more abundantly supplied with muscle spindles. In the present study, the hypothesis was tested that spindle afferent inputs play a major role in ..
  67. ncbi "Proprioceptive signature" of cursive writing in humans: a multi-population coding
    Jean Pierre Roll
    Laboratoire de Neurobiologie Humaine, UMR 6149 Université de Provence CNRS, 13397, Marseille, France
    Exp Brain Res 157:359-68. 2004
    ..First it was proposed to determine whether the ensemble of muscle spindles give rise to a unique, specific, and reproducible feedback information characterizing each letter, number or ..
  68. ncbi Task dependent gain regulation of spinal circuits projecting to the human flexor carpi radialis
    Timothy J Carroll
    Health and Sports Science, LG02 M Wallace Wurth Building, School of Medical Sciences, The University of New South Wales, Sydney, New South Wales, Australia
    Exp Brain Res 161:299-306. 2005
    ..Transmission through both of these pathways probably contributes to the inability of individuals to maximally activate FCR during radial deviation MVCs...
  69. ncbi Synaptic input from homonymous group I afferents in m. longissimus lumborum motoneurons in the L4 spinal segment in cats
    Junko Akatani
    Department of Veterinary Physiology, Yamaguchi University, 753 8515, Yamaguchi City, Japan
    Exp Brain Res 156:396-8. 2004
    ..while the motoneuron activities carried out by polysynaptic pathways from the far spinal segments have independent intrinsic properties...
  70. ncbi Speed-related spinal excitation from ankle dorsiflexors to knee extensors during human walking
    Caroline Iglesias
    INSERM, U731, 75013, Paris, France
    Exp Brain Res 188:101-10. 2008
    ..It is suggested that the purpose of the reflex is to ensure knee stability at moderate-to-high walking speeds...
  71. ncbi Re-examination of the possible role of Golgi tendon organ and muscle spindle reflexes in proprioceptive neuromuscular facilitation muscle stretching
    Gordon Chalmers
    Department of Physical Education, Health and Recreation, Western Washington University, Bellingham, WA, USA
    Sports Biomech 3:159-83. 2004
    ..Studies reviewed indicate that changes in the ability to tolerate stretch and/or the viscoelastic properties of the stretched muscle, induced by PNF procedures, are possible mechanisms...
  72. ncbi Muscle proprioceptive feedback and spinal networks
    U Windhorst
    Center for Physiology and Pathophysiology, University of Goettingen, Humboldtallee 23, D 37073 Goettingen, Germany
    Brain Res Bull 73:155-202. 2007
    ..The scope will at times extend beyond the narrow confines of spinal circuits in order to integrate them into wider contexts and concepts...
  73. ncbi Initiating extension of the lower limbs in subjects with complete spinal cord injury by epidural lumbar cord stimulation
    B Jilge
    TU BioMed Association for Biomedical Engineering, Vienna University of Technology, Wiedner Hauptstrasse 8 10 114, 1040 Vienna, Austria
    Exp Brain Res 154:308-26. 2004
    ..In the electromyograms of the lower-limb muscle groups, such activity is reflected as a characteristic spatiotemporal pattern of compound motor-unit potentials...
  74. pmc Internal models of limb dynamics and the encoding of limb state
    Eun Jung Hwang
    Laboratory for Computational Motor Control, Department of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA
    J Neural Eng 2:S266-78. 2005
    ..We developed a set of equations based on properties of muscle spindles that estimated spindle discharge as a function of the limb's state during reaching and drawing of circles...
  75. ncbi Electrical stimulation of the human common peroneal nerve elicits lasting facilitation of cortical motor-evoked potentials
    Michael E Knash
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, T6G 2S2, Canada
    Exp Brain Res 153:366-77. 2003
    ..In summary, repetitive electrical stimulation of the CP nerve elicits lasting changes in corticospinal excitability, possibly as a result of co-activating motor and sensory fibres...
  76. ncbi Low-threshold afferent signalling of viscous loads during voluntary movements of the human digits
    Penelope A McNulty
    Prince of Wales Medical Research Institute and University of New South Wales, Sydney, Australia
    Neuroreport 19:1049-54. 2008
    ..No single class of afferent provides a coherent signal of viscosity. These data suggest that the central nervous system compares the population response of different inputs to discriminate viscosity...
  77. ncbi Differential modulation of primary afferent depolarization of segmental and ascending intraspinal collaterals of single muscle afferents in the cat spinal cord
    P Rudomin
    Department of Physiology, Biophysics and Neurosciences, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico City, Mexico
    Exp Brain Res 156:377-91. 2004
    ....
  78. ncbi Phase- and task-specific modulation of soleus H-reflexes during drop-jumps and landings
    Christian Leukel
    Department of Sport Science, University of Freiburg, Schwarzwaldstr 175, 79117, Freiburg, Germany
    Exp Brain Res 190:71-9. 2008
    ..46 +/- 0.15; EH: 0.44 +/- 0.16). The present study provides further evidence of phase-specific (GND vs. SLR) and task-specific modulation of SOL Ia afferent input. These modulations were thought to be initiated prior to touch down...
  79. ncbi Tonic differential supraspinal modulation of PAD and PAH of segmental and ascending intraspinal collaterals of single group I muscle afferents in the cat spinal cord
    P Rudomin
    Department of Physiology, Biophysics and Neurosciences del IPN, Centro de Investigacion y de Estudios Avanzados, Av Instituto Politecnico Nacional 2508, DF 07300, Mexico
    Exp Brain Res 159:239-50. 2004
    ....
  80. ncbi Differentiation of hamstring short latency versus medium latency responses after tibia translation
    B Friemert
    Department of Surgery, Hospital of the Federal Armed Forces Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany
    Exp Brain Res 160:1-9. 2005
    ..As a basis for future work the algorithm presented may become a useful tool to differentiate which afferent pathways play a role in initiating hamstring activity...
  81. ncbi Change of stretch reflex threshold in spasticity: effect of botulinum toxin injections
    G Stampacchia
    Dipartimento di Neuroscienze, Neuroriabilitazione, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy
    Arch Ital Biol 142:265-73. 2004
    ..This effect explains how Botulinum toxin increases the stretch reflex threshold in spastic muscles...
  82. ncbi Interest of peripheral anesthetic blocks as a diagnosis and prognosis tool in patients with spastic equinus foot: a clinical and electrophysiological study of the effects of block of nerve branches to the triceps surae muscle
    Kevin Buffenoir
    Service de Neurochirurgie, Hopital Henri Mondor, Assistance Publique Hopitaux de Paris, Creteil, France
    Clin Neurophysiol 116:1596-600. 2005
    ..To evaluate clinically and electrophysiologically the effects of selective anesthetic blocks of motor nerve branches to the triceps surae muscle on lower limb stretch reflex in patients with spastic equinus foot...
  83. ncbi Proprioceptive feedback in humans expresses motor invariants during writing
    Frederic Albert
    Laboratoire de Neurobiologie Humaine, UMR 6149, Universite de Provence CNRS, Centre St Charles, 3, Place Victor Hugo, 13331, Marseille Cedex 03, France
    Exp Brain Res 164:242-9. 2005
    ..The results demonstrate that the neuronal trajectories attained from populations of muscle spindles clearly depict the path and kinematic parameters and express the movement invariants, i.e...
  84. ncbi Estimation of muscle spindle information rate by pattern matching and the effect of gamma system activity on parallel spindles
    Y Tock
    Electrical Engineering Department, Technion, Haifa, Israel
    Biol Cybern 92:316-32. 2005
    ..The results indicate that the gamma system has an important role in enhancing information transmission from ensembles of MSs to the spinal cord...
  85. ncbi Functional sparing of intrafusal muscle fibers in muscular dystrophies
    Jean Marc Aimonetti
    Laboratoire de Neurobiologie Humaine, UMR 6149, Universite de Provence CNRS, Pôle 3C Case B, Centre de Saint Charles 3, Place Victor Hugo, 13331 Marseille, France
    Muscle Nerve 32:88-94. 2005
    ..These findings argue for preserved proprioceptive functions of muscle spindles. However, it is unclear whether the function of intrafusal muscle fibers is spared, i.e...
  86. ncbi Temperature modulates P2X receptor-mediated cardiovascular responses to muscle afferent activation
    Zhaohui Gao
    Heart and Vascular Institute, Division of Cardiology, Department of Medicine, H047, Penn State College of Medicine, Milton S Hershey Medical Center, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Heart Circ Physiol 291:H1255-61. 2006
    ..These data indicate that the effect of P2X receptor on reflex muscle response is sensitive to alternations of muscle temperature and that elevated temperature attenuates the response...
  87. ncbi Changes in stretch reflex excitability are related to "giving way" symptoms in patients with anterior cruciate ligament rupture
    M Melnyk
    Institute of Orthopaedic Research and Biomechanics, University of Ulm, Ulm, Germany
    J Neurophysiol 97:474-80. 2007
    ....
  88. ncbi Classification of muscle spindle afferents innervating the masseter muscle in rats
    Radi Masri
    Department of Biomedical Sciences, Baltimore College of Dental Surgery, University of Maryland Baltimore, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Arch Oral Biol 51:740-7. 2006
    Taylor et al. [Taylor, A., Durbaba, R., Rodgers, J.F., 1992a. The classification of afferents from muscle spindles of the jaw-closing muscles of the cat...
  89. ncbi Reflex gain of muscle spindle pathways during fatigue
    A Biro
    School of Kinesiology and Health Science, York University, Toronto, ON, Canada
    Exp Brain Res 177:157-66. 2007
    ..and tendon tap, in which the motor neuron pool is modulated by both short- and long-loop activation from muscle spindles, were elicited before and after a fatigue task...
  90. ncbi Influence of age on dynamic position sense: evidence using a sequential movement task
    Sangeetha Madhavan
    Graduate Program in Physical Therapy and Rehabilitation Science, 1 252 Medical Education Building, The University of Iowa, Iowa City, IA, 52242 1190, USA
    Exp Brain Res 164:18-28. 2005
    ..Rehabilitative training methods that improve dynamic position sense of the ankles may improve physical function and balance in the elderly...
  91. ncbi Effects in feline gastrocnemius-soleus motoneurones induced by muscle fatigue
    Alexander I Kostyukov
    Department of Movement Physiology, Bogomoletz Institute of Physiology, National Academy of Sciences, Bogomoletz Street 4, 01024 Kiev, Ukraine
    Exp Brain Res 163:284-94. 2005
    ..Presynaptic inhibition could be one of the mechanisms involved, but homosynaptic depression in the FST-activated group Ia afferents may also have contributed...
  92. ncbi The influence of perturbation duration and velocity on the long-latency response to stretch in the biceps muscle
    Gwyn N Lewis
    Sensory Motor Performance Program, Rehabilitation Institute of Chicago, 345 E Superior St, Chicago, IL 60611, USA
    Exp Brain Res 163:361-9. 2005
    ..The effect of the duration of perturbation on the M2 may account for the conflicting characteristics of the M2 that have been provided by previous studies applying mechanical or electrical perturbations of varying time durations...
  93. ncbi Changes in human muscle spindle sensitivity during a proprioceptive attention task
    Valérie Hospod
    Neurobiologie Intégrative et Adaptative, Aix Marseille Universite, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 6149, 13331 Marseille Cedex 03, France
    J Neurosci 27:5172-8. 2007
    ..It is suggested that the altered muscle spindle sensitivity is because of selective changes in fusimotor control, the consequence of which might be to feed the brain movement trajectory information that is more accurate...
  94. pmc Vertebral position alters paraspinal muscle spindle responsiveness in the feline spine: effect of positioning duration
    Weiqing Ge
    Palmer Center for Chiropractic Research, 741 Brady Street, Davenport, IA 52803, USA
    J Physiol 569:655-65. 2005
    ..We investigated whether the history of a vertebra's position can affect signalling from paraspinal muscle spindles. Single unit recordings were obtained from muscle spindle afferents in the L6 dorsal roots of 30 Nembutal-..
  95. ncbi Sympathetic nerve responses to muscle contraction and stretch in ischemic heart failure
    Satoshi Koba
    Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Heart Circ Physiol 294:H311-21. 2008
    ..We suggest that muscle afferent-mediated sympathetic outflows contribute to the abnormal regulation of peripheral blood flow seen during exercise in CHF...
  96. ncbi Reflex reciprocal facilitation of antagonist muscles in spinal cord injury
    R Xia
    Department of Physical Medicine and Rehabilitation, Northwestern University, Chicago, IL, USA
    Spinal Cord 43:14-21. 2005
    ..Electromyographic study in complete and incomplete spinal cord injury (SCI)...
  97. ncbi Conditioning Ia-afferent stimulation reduces the soleus Hoffman reflex in humans when muscle spindles are assumed to be inactive
    M M Nordlund
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neurosci Lett 366:250-3. 2004
    ..In lengthening, H:M was unaffected by conditioning. These findings support that HPAD reduces the synaptic efficacy of Ia-afferents during active shortening, active and passive lengthening, but not passive shortening...
  98. ncbi Effect of slow, small movement on the vibration-evoked kinesthetic illusion
    P J Cordo
    Neurological Sciences Institute, Oregon Health and Science University, 505 NW 185th Ave, Beaverton, OR 97006, USA
    Exp Brain Res 167:324-34. 2005
    ..We discuss whether the exaggerated perception of slow, small movement during vibration is better explained by contributions of non muscle spindle Ia afferents or by changes in the mechanical transmission of vibration to the receptor...
  99. ncbi Positive proprioceptive feedback elicited by isometric contractions of ankle flexors on pretibial motoneurons in cats
    L Brizzi
    Centre National de la Recherche Scientifique 2361, Unite Mixte de Recherche 8119, Universite Rene Descartes, 75270 Paris, France
    J Neurophysiol 88:2207-14. 2002
    ..This contraction-induced Ia excitatory feedback in ankle flexors might either reinforce Ia-induced reflexes when these muscles are lengthened or help to lift the leg over an obstacle...
  100. ncbi Continuous, bilateral Achilles' tendon vibration is not detrimental to human walk
    G Courtine
    Groupe d'Analyse du Mouvement, , Campus Universitaire, Dijon, France
    Brain Res Bull 55:107-15. 2001
    ..These findings would speak for a selective gating of Ia input during locomotion and emphasise the notion that the central nervous system can cope with an unusual continuous input along the Ia fibres from a key muscle like the soleus...
  101. ncbi Intersegmental neuronal pathways in sacrococcygeal spinal cord (S3-Co3) activated by electrical stimulation of tail muscle nerves with low threshold in low spinal cats
    Junko Akatani
    Department of Veterinary Physiology, Faculty of Agriculture, Yamaguchi University, Yamaguchi 753 8515, Japan
    Brain Res 924:30-8. 2002
    ..The results of the present experiments suggest that continuous tail movements along the tail are performed by group I reflex pathways...

Research Grants53

  1. Somatosensory feedback controlling a neuroprosthesis
    Douglas J Weber; Fiscal Year: 2010
    ..known to cause plastic changes in spinal neuronal circuitry potentially altering the response properties of muscle spindles. Using a decerebate cat preparation, the following state variables for the hindlimb will be studied: position,..
  2. Sleep, proprioception, and forebrain activity in infant mutant mice
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..we propose here to test infant mutant mice that are genetically engineered such that they fail to develop muscle spindles, the sensory organs essential for proprioception...
  3. MYOSIN GENE DIVERSITY AND FUNCTION
    LESLIE ANNE LEINWAND; Fiscal Year: 2013
    ..two phylogenetically distant myosins is limited to specialized muscles (extraocular muscles and the sensory muscle spindles) and brain...
  4. Sensory innervation-dependent transcriptional regulation in muscle
    LARRY B FROMM; Fiscal Year: 2010
    ..b>Muscle spindles are sensory receptors embedded within muscle that detect changes in muscle length...
  5. Spatial and temporal control of targeted limb movement
    Paul Cordo; Fiscal Year: 2010
    ..2 will investigate whether, during precise voluntary joint movement, antagonist muscles are co-activated and whether, as a consequence, the sensitivity of antagonist muscle spindles is enhanced by fusimotor drive.
  6. KINESTHETIC MECHANISMS IN THE TRIGEMINAL SYSTEM
    Norman Capra; Fiscal Year: 2005
    ..Altered jaw muscle spindles activity may disturb motor activity and kinesthetic sensibility...
  7. Somatosensory Function in Speech Learning and Perception
    Takayuki Ito; Fiscal Year: 2011
    ..important for speech control since a number of articulatory muscles lack traditional muscle proprioceptors (muscle spindles and tendon organs)...
  8. STOCHASTIC RESONANCE IN HUMAN MUSCLE SPINDLES
    Paul Cordo; Fiscal Year: 2000
    ..Unlike typical sensory receptors, muscle spindles have both an efferent ("fusimotor") and an afferent nerve supply...
  9. ENCODING IN SOMATIC SENSE ORGANS
    EDWARD PERL; Fiscal Year: 2001
    ..of impulse initiation, as well as their subsequent propagation, will be studied in Pacinian corpuscles and in muscle spindles. Are there multiple pacemaker sites in receptors supplied by several branches of the sensory axon? Is there ..
  10. MECHANISMS OF DAMAGE-INDUCED TRIGEMINAL REORGANIZATION
    MARK JACQUIN; Fiscal Year: 2004
    ..Egr3, regulate the development of limb proprioceptive axons and how these actions modify the function of muscle spindles. PROJECT 3 will reveal the necessary conditions for maintenance of patterns in the V neuraxis; anatomical ..
  11. ANATOMY OF IDENTIFIED JAW-MUSCLE SPINDLE AFFERENTS
    Dean Dessem; Fiscal Year: 1990
    ..for these studies because of the complex morphology and mode of afferent terminations that exist in jaw-muscle spindles and their correspondingly diverse afferent responses...
  12. NEURAL MECHANISMS OF POSITION SENSE
    Francis Clark; Fiscal Year: 1992
    ..rely on continuously available, though not necessarily ongoing, sensory from receptors in muscles, likely the muscle spindles that measure muscle length...
  13. DEVELOPMENT OF SENSORY/MOTOR SYNAPSES IN THE SPINAL CORD
    Eric Frank; Fiscal Year: 2005
    ..Sensory neurons supplying muscle spindles (Ia afferents) are primarily sensitive to muscle length; they project into the spinal cord where they make ..
  14. VERTEBRAL POSITION ALTERS MUSCLE SPINDLE SENSITIVITY
    Joel Pickar; Fiscal Year: 2006
    ..the applicant indicate that the mechanical history of a vertebra alters the sensitivity of lumbar paraspinal muscle spindles to subsequent vertebral movement...
  15. Does spinal manipulation speed determine neural response
    Joel Pickar; Fiscal Year: 2002
    ..The proposed experiments will determine how muscle spindles and Golgi tendon organs in lumbar paraspinal muscle respond to the time-varying impulse of a spinal ..
  16. NEUROPHYSIOLOGICAL CONSEQUENCES OF LUMBAR FACET MOVEMENT
    Joel Pickar; Fiscal Year: 2001
    ....
  17. SPATIAL AND TEMPORAL CONTROL OF TARGETED LIMB MOVEMENTS
    Paul Cordo; Fiscal Year: 2006
    ..hypothesis to be investigated is that, in active movement, the primary source of proprioceptive input is muscle spindles in the lengthening, "antagonist" muscles, rather than muscle spindles in the contracting, "agonist" muscles...
  18. Interaction torques in voluntary turning and reaching
    James R Lackner; Fiscal Year: 2010
    ..The experimental findings and analyses will provide a comprehensive evaluation of the role of feedforward predictive mechanisms in the control of reaching movements involving body rotation. ..
  19. COORDINATION OF SITTING UP
    Paul Cordo; Fiscal Year: 2001
    ..The vertical forces produced on the support surface will be recorded along with segmental kinematics and muscle (EMG) activity. ..
  20. Myosin Isoforms in Relation to Function in Human Heart
    Richard L Moss; Fiscal Year: 2010
    ....
  21. SPINAL MECHANISMS REGULATING MUSCLE AND LIMB MECHANICS
    Martin Pinter; Fiscal Year: 2006
    ..abstract_text> ..
  22. ACL injury mechanisms & offaxis neuromuscular diagnosis & training
    Li Qun Zhang; Fiscal Year: 2010
    ....
  23. Linking motor imagery to motor execution
    Sheng Li; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  24. Electrophysiologic Measurements in Diabetic Neuropathy
    Joseph Arezzo; Fiscal Year: 2007
    ..If successful, these studies will result in new methods, more sensitive animal models and a better understanding of the nature, magnitude, time course, and response to therapy of functional deficits in DAN. ..
  25. Non-Invasive System for Identifying Neural Behavior
    Carlo De Luca; Fiscal Year: 2009
    ..It will be useful to clinicians for assessing the degree of dysfunction in upper motoneuron diseases such as Cerebral Palsy, Parkinson's Disease, ALS, Stroke, and other disorders. ..
  26. Multi-Joint Sensorimotor Dysfunction of the Stroke Arm
    BRIAN SCHMIT; Fiscal Year: 2008
    ..In addition, conventional therapies may be applied more efficiently or effectively using the principles that will be demonstrated by this study. ..
  27. Reflex Regulation of Motor function in Human SCI
    BRIAN D contact SCHMIT; Fiscal Year: 2010
    ..This study has important implications for therapies aimed at restoring movement in SCI and for the treatment of spasticity to improve functional movements. ..
  28. Bilateral activation in upper-limb stroke rehabilitation
    Gwyn Lewis; Fiscal Year: 2006
    ....
  29. Mechanical Function of Cardiac Myosins
    Richard Moss; Fiscal Year: 2004
    ..Results from these studies should provide new insights into the mechanisms by which the work and power generating capabilities of myosin differ in various MHC isoforms. ..
  30. NEUROPHYSIOLOGICAL STUDY OF DORSAL SPINOCEREBELLAR TRACT
    Richard Poppele; Fiscal Year: 2004
    ..A better understanding of the normal function of the motor control system can be expected to lead to improved therapies and rehabilitation strategies even if it does not lead immediately to "cures". ..
  31. NEUROTROPHIN 3 IN NEURONAL INJURY AND DISEASE
    Douglas Wright; Fiscal Year: 2002
    ..Results from these studies will define new biological actions of NT-3 and reveal how manipulation of the trophic support of neurons may be useful to treat pathologic neural conditions. ..
  32. ROLE OF INTERNEURONAL CIRCUITS IN HUMAN SPINAL CORD INJU
    BRIAN SCHMIT; Fiscal Year: 2004
    ..The principles developed in this study will form the basis for new treatment modalities for spasticity in spinal cord injury. ..
  33. HARNESSING MOTONEURON ACTIVITY: FROM LAB TO CLINIC
    Carlo De Luca; Fiscal Year: 2004
    ..As well as testing specific hypotheses, these studies will be used to test and improve the evolving design of the new decomposition system. ..
  34. NERVE-MUSCLE INTERACTIONS DURING JAW MUSCLE DEVELOPMENT
    CHARLES WIDMER; Fiscal Year: 2002
    ..These two hypotheses will be tested in three specific aims that include in vivo and in vitro investigations. ..
  35. Developing an intelligent & portable stretching device
    Li Qun Zhang; Fiscal Year: 2006
    ..The overall objectives of the Phase II project are to develop an effective, portable, low-cost, and user-friendly intelligent stretcher, suitable and economical for patients to use in clinic or home and ready for commercialization. ..
  36. Olympus FV 1000 Confocal Microscope for Neurobiology and Cellular Biology Researc
    Francisco Alvarez; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  37. BASAL LAMINA MOLECULES AND SYNAPTOGENESIS
    MICHAEL WERLE; Fiscal Year: 2003
    ....
  38. Confer. Neural Mechanisms in Cardiovascular Regulation
    MARK CHAPLEAU; Fiscal Year: 2002
    ..Time will be allotted for informal discussions and social interaction. Scientists from the United States and other countries, young investigations and women are well-represented in the program. ..
  39. EEG BASED BRAIN COMPUTER INTERFACE
    JONATHAN WOLPAW; Fiscal Year: 2003
    ..If successful, this work is likely to improve performance and versatility of EEG-based communication and interface systems. ..
  40. NEUROMECHANICS OF KNEE EXTENSOR/MALALIGNMENT
    Li Qun Zhang; Fiscal Year: 2002
    ..Changes in the above properties induced by patellar malalignment and correction induced by patellar taping will be quantified using the above designs. ..
  41. Contribution of tactile information to arm movements
    Ely Rabin; Fiscal Year: 2004
    ..This will shed light on issues concerning sensorimotor integration of tactile input in individuals with PD, and point toward intervention strategies. ..
  42. MOLECULAR MECHANISMS MEDIATING NERVE MUSCLE INTERACTIONS
    Warren G Tourtellotte; Fiscal Year: 2010
    ....
  43. PRO-Surveyor: Device for Capturing Patient Reported Outcome Data in Children
    Nadine Connor; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  44. The utility of rTMS to enhance hand function in stroke
    Gwyn Lewis; Fiscal Year: 2007
    ..This will be applicable to a large population of US adults with deficits in hand function resulting from stroke. [unreadable] [unreadable] [unreadable]..
  45. Neuromechanical changes caused by stroke & stretching
    Li Qun Zhang; Fiscal Year: 2006
    ..The long-term goals are to provide effective, convenient, and low-cost treatments of spastic limbs in neurologically impaired patients with quantitative outcome evaluation in multiple aspects. ..
  46. Wearable-Sensor System for Monitoring Motor Function
    Carlo J De Luca; Fiscal Year: 2010
    ..The successful development of this technology will be transferred for commercial development with the financial assistance of the Massachusetts Community Technology Foundation. ..