enteric nervous system

Summary

Summary: Two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. (From Kandel, Schwartz, and Jessel, Principles of Neural Science, 3d ed, p766)

Top Publications

  1. ncbi Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development
    Laure Stanchina
    INSERM, U654, Bases moléculaires et cellulaires des maladies génétiques, Hopital Henri Mondor, Creteil, F 94000, France Université Paris 12, Faculte de Medecine, IFR10, Creteil, F 94000, France
    Dev Biol 295:232-49. 2006
  2. pmc Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness
    Genevieve M Kruger
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:657-69. 2002
  3. pmc Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
    Cátia Laranjeira
    Division of Molecular Neurobiology, Medical Research Council National Institute for Medical Research, London, United Kingdom
    J Clin Invest 121:3412-24. 2011
  4. pmc Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut
    Nancy M Joseph
    Center for Stem Cell Biology, Howard Hughes Medical Institute, and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 121:3398-411. 2011
  5. ncbi Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system
    Chihiro Nishiyama
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Neurosci 15:1211-8. 2012
  6. ncbi Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies
    Tiffany A Heanue
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Neurosci 8:466-79. 2007
  7. ncbi GDNF is a chemoattractant for enteric neural cells
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, 3010, Australia
    Dev Biol 229:503-16. 2001
  8. ncbi Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    A Schuchardt
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Nature 367:380-3. 1994
  9. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
  10. ncbi The enteric nervous system
    Valentina Sasselli
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Dev Biol 366:64-73. 2012

Detail Information

Publications310 found, 100 shown here

  1. ncbi Interactions between Sox10, Edn3 and Ednrb during enteric nervous system and melanocyte development
    Laure Stanchina
    INSERM, U654, Bases moléculaires et cellulaires des maladies génétiques, Hopital Henri Mondor, Creteil, F 94000, France Université Paris 12, Faculte de Medecine, IFR10, Creteil, F 94000, France
    Dev Biol 295:232-49. 2006
    The requirement for SOX10 and endothelin-3/EDNRB signalling pathway during enteric nervous system (ENS) and melanocyte development, as well as their alterations in Waardenburg-Hirschsprung disease (hypopigmentation, deafness and absence ..
  2. pmc Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness
    Genevieve M Kruger
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:657-69. 2002
    ..The persistence of NCSCs in the adult PNS opens up new possibilities for regeneration after injury or disease...
  3. pmc Glial cells in the mouse enteric nervous system can undergo neurogenesis in response to injury
    Cátia Laranjeira
    Division of Molecular Neurobiology, Medical Research Council National Institute for Medical Research, London, United Kingdom
    J Clin Invest 121:3412-24. 2011
    The enteric nervous system (ENS) in mammals forms from neural crest cells during embryogenesis and early postnatal life...
  4. pmc Enteric glia are multipotent in culture but primarily form glia in the adult rodent gut
    Nancy M Joseph
    Center for Stem Cell Biology, Howard Hughes Medical Institute, and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    J Clin Invest 121:3398-411. 2011
    It is unclear whether neurogenesis occurs in the adult mammalian enteric nervous system (ENS)...
  5. ncbi Trans-mesenteric neural crest cells are the principal source of the colonic enteric nervous system
    Chihiro Nishiyama
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe, Japan
    Nat Neurosci 15:1211-8. 2012
    ..During development, the enteric neural crest cells (ENCCs) that give rise to the enteric nervous system (ENS) migrate and colonize the entire length of the gut, which undergoes substantial growth and ..
  6. ncbi Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies
    Tiffany A Heanue
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Nat Rev Neurosci 8:466-79. 2007
    The enteric nervous system (ENS) has been explored by developmental neurobiologists and medical researchers for decades...
  7. ncbi GDNF is a chemoattractant for enteric neural cells
    H M Young
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, 3010, Australia
    Dev Biol 229:503-16. 2001
    ..We conclude that GDNF may promote the migration of crest cells throughout the gastrointestinal tract, prevent them from straying out of the gut (into the mesentery and pharyngeal and pelvic tissues), and promote directed axon outgrowth...
  8. ncbi Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret
    A Schuchardt
    Department of Genetics, College of Physicians and Surgeons, Columbia University, New York, New York 10032
    Nature 367:380-3. 1994
    ..Ret is thus an essential component of a signalling pathway required for renal organogenesis and enteric neurogenesis...
  9. ncbi The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
    A Pattyn
    Laboratoire de Genetique et Physiologie du Developpement, Developmental Biology Institute of Marseille, CNRS INSERM Université de la Méditterranée AP de Marseille, France
    Nature 399:366-70. 1999
    ..In the anlagen of the enteric nervous system and the sympathetic ganglia, Phox2b is needed for the expression of the GDNF-receptor subunit Ret and for ..
  10. ncbi The enteric nervous system
    Valentina Sasselli
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Dev Biol 366:64-73. 2012
    The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, consists of numerous types of neurons, and glial cells, that are distributed in two intramuscular plexuses that extend along the entire length of ..
  11. ncbi Developmental determinants of the independence and complexity of the enteric nervous system
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    Trends Neurosci 33:446-56. 2010
    b>Enteric nervous system (ENS) development is relevant to Hirschsprung's disease (HSCR; congenital aganglionosis of the terminal bowel), which is still imperfectly treated...
  12. pmc Bone morphogenetic proteins regulate enteric gliogenesis by modulating ErbB3 signaling
    ALCMENE CHALAZONITIS
    Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA
    Dev Biol 350:64-79. 2011
    ..These observations support the hypotheses that BMPs are required for enteric gliogenesis and act by promoting responsiveness of ENCDC to ErbB3 ligands such as GGF2...
  13. ncbi Lessons from the porcine enteric nervous system
    D R Brown
    Department of Veterinary Pathobiology, College of Veterinary Medicine, University of Minnesota, St Paul, Minnesota, USA
    Neurogastroenterol Motil 16:50-4. 2004
    ..functional and pathological similarities to the human digestive tract and the organization of the porcine enteric nervous system, like that of the human, appears to be more complex than that of commonly investigated guinea-pig ..
  14. pmc 5-HT4 receptor-mediated neuroprotection and neurogenesis in the enteric nervous system of adult mice
    Min Tsai Liu
    Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA
    J Neurosci 29:9683-99. 2009
    Although the mature enteric nervous system (ENS) has been shown to retain stem cells, enteric neurogenesis has not previously been demonstrated in adults...
  15. ncbi Cell proliferation drives neural crest cell invasion of the intestine
    Matthew J Simpson
    Department of Mathematics and Statistics, University of Melbourne, and The Murdoch Childrens Research Institute, Victoria 3010, Australia
    Dev Biol 302:553-68. 2007
    ..is the directional invasion and colonization of the gut by vagal neural crest cells that establish the enteric nervous system. An assay using gut organ culture with chick-quail grafting is used for this purpose...
  16. pmc Characterisation and transplantation of enteric nervous system progenitor cells
    Sarah Almond
    Institute of Child Health, Royal Liverpool University Children s Hospital, Alder Hey, Liverpool, UK
    Gut 56:489-96. 2007
    b>Enteric nervous system (ENS) progenitor cells have been postulated to be an appropriate source of cells for the treatment of Hirschsprung's disease...
  17. ncbi Beta1 integrins are required for the invasion of the caecum and proximal hindgut by enteric neural crest cells
    Marie A Breau
    UMR144, CNRS Institut Curie, Paris Cedex 05, France
    Development 136:2791-801. 2009
    ..These findings suggest that beta1 integrins are required to overcome the tenascin-C-mediated inhibition of migration within the caecum and proximal hindgut and to enhance fibronectin-dependent migration in these regions...
  18. pmc Prospective identification and isolation of enteric nervous system progenitors using Sox2
    Tiffany A Heanue
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Stem Cells 29:128-40. 2011
    ..The enteric nervous system (ENS) regulates important gut functions, including controlling peristaltic muscular contractions, and ..
  19. pmc Vitamin A facilitates enteric nervous system precursor migration by reducing Pten accumulation
    Ming Fu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 137:631-40. 2010
    Hirschsprung disease is a serious disorder of enteric nervous system (ENS) development caused by the failure of ENS precursor migration into the distal bowel...
  20. ncbi Building stable chains with motile agents: Insights into the morphology of enteric neural crest cell migration
    Kerry A Landman
    Department of Mathematics and Statistics, University of Melbourne, Victoria 3010, Australia
    J Theor Biol 276:250-68. 2011
    A defining characteristic of the normal development of the enteric nervous system (ENS) is the existence of an enteric neural crest (ENC) cell colonization wave, where the ENC cells form stable chains often associated with axons and near ..
  21. ncbi Behavior of enteric neural crest-derived cells varies with respect to the migratory wavefront
    Noah R Druckenbrod
    Department of Anatomy, Neuroscience Training Program, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Dev Dyn 236:84-92. 2007
    ..This behavior is probably responsible for the unique reticulated arrangement of ganglia in the enteric nervous system. As cells become positioned farther behind the wavefront, they exhibit more restricted movement and varied ..
  22. ncbi The pattern of neural crest advance in the cecum and colon
    Noah R Druckenbrod
    Department of Anatomy, and Neuroscience Training Program, University of Wisconsin Medical School, Madison, WI 53706, USA
    Dev Biol 287:125-33. 2005
    ..enter the gut mesenchyme at the pharynx, and migrate as strands of cells to the terminal bowel to form the enteric nervous system. We generated embryos containing fluorescent enteric neural crest-derived cells (ENCCs) by mating Wnt1-Cre ..
  23. ncbi N-cadherin and β1-integrins cooperate during the development of the enteric nervous system
    Florence Broders-Bondon
    Institut Curie CNRS UMR144, Paris, France
    Dev Biol 364:178-91. 2012
    Cell adhesion controls various embryonic morphogenetic processes, including the development of the enteric nervous system (ENS)...
  24. pmc Building a brain in the gut: development of the enteric nervous system
    A M Goldstein
    Department of Pediatric Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Genet 83:307-16. 2013
    The enteric nervous system (ENS), the intrinsic innervation of the gastrointestinal tract, is an essential component of the gut neuromusculature and controls many aspects of gut function, including coordinated muscular peristalsis...
  25. ncbi On the role of differential adhesion in gangliogenesis in the enteric nervous system
    Emily J Hackett-Jones
    Department of Mathematics and Statistics, University of Melbourne, Victoria 3010, Australia
    J Theor Biol 287:148-59. 2011
    A defining characteristic of the normal development of the enteric nervous system (ENS) is the existence of mesoscale patterned entities called ganglia...
  26. ncbi Optical clearing improves the imaging depth and signal-to-noise ratio for digital analysis and three-dimensional projection of the human enteric nervous system
    Y A Liu
    Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan
    Neurogastroenterol Motil 23:e446-57. 2011
    ..and fibers, the microtome-based 2-dimensional histology provides only a limited perspective of the enteric nervous system. To visualize the enteric plexus, we applied optical clearing to avoid scattering in the human ileum to ..
  27. ncbi Neuron and glia generating progenitors of the mammalian enteric nervous system isolated from foetal and postnatal gut cultures
    Nadege Bondurand
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 130:6387-400. 2003
    ..gave rise to colonies containing many of the neuronal subtypes and glial cells present in the mammalian enteric nervous system. These progenitors were also capable of colonising wild-type and aganglionic gut in organ culture and had ..
  28. pmc Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    James G Greene
    Department of Neurology, Emory University School of Medicine, 505H Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Exp Neurol 218:154-61. 2009
    ....
  29. ncbi The enteric nervous system and neurogastroenterology
    John B Furness
    Department of Anatomy and Neuroscience, University of Melbourne, Grattan Street, Parkville, VIC 3010, Australia
    Nat Rev Gastroenterol Hepatol 9:286-94. 2012
    ..gastrointestinal tract, liver, gallbladder and pancreas and encompasses control of digestion through the enteric nervous system (ENS), the central nervous system (CNS) and integrative centers in sympathetic ganglia...
  30. ncbi Novel mutations at RET ligand genes preventing receptor activation are associated to Hirschsprung's disease
    Macarena Ruiz-Ferrer
    Unidad de Gestión Clínica de Genética, Reproducción y Medicina Fetal, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Avda Manuel Siurot s n, Seville, Spain
    J Mol Med (Berl) 89:471-80. 2011
    ..To support the role of PSPN R91C in HSCR phenotype, enteric nervous system (ENS) progenitors were isolated from human postnatal gut tissues and expression of GFRα4, the main co-..
  31. pmc Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes
    Yien Ming Kuo
    Department of Medicine, University of California San Francisco, San Francisco, CA 94143, USA
    Hum Mol Genet 19:1633-50. 2010
    ..Both the A53T and A30P lines show robust abnormalities in enteric nervous system (ENS) function and synuclein-immunoreactive aggregates in ENS ganglia by 3 months of age...
  32. ncbi Effects of different regions of the developing gut on the migration of enteric neural crest-derived cells: a role for Sema3A, but not Sema3F
    R B Anderson
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Vic, Australia
    Dev Biol 305:287-99. 2007
    The enteric nervous system arises from vagal (caudal hindbrain) and sacral level neural crest-derived cells that migrate into and along the developing gut...
  33. ncbi Role of interstitial cells of Cajal in neural control of gastrointestinal smooth muscles
    S M Ward
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV, USA
    Neurogastroenterol Motil 16:112-7. 2004
    ..ICC-IM also play a role in generating unitary potentials in the stomach that contribute to the excitability of the gastric fundus and antrum...
  34. ncbi Neural crest regionalisation for enteric nervous system formation: implications for Hirschsprung's disease and stem cell therapy
    Dongcheng Zhang
    Embryology Research Group, Murdoch Childrens Research Institute, Parkville 3052, Victoria, Australia
    Dev Biol 339:280-94. 2010
    Midbrain, hindbrain and vagal neural crest (NC) produced abundant enteric nervous system (ENS) in co-grafted aneural hindgut and midgut, using chick-quail chorio-allantoic membrane grafts, forming complete myenteric and submucosal ..
  35. ncbi Conditional ablation of GFRalpha1 in postmigratory enteric neurons triggers unconventional neuronal death in the colon and causes a Hirschsprung's disease phenotype
    Toshihiro Uesaka
    Laboratory for Neuronal Differentiation and Regeneration, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Development 134:2171-81. 2007
    ..This study reveals an essential role for GFRalpha1 in the survival of enteric neurons and suggests that caspase-independent death can be triggered by abolition of neurotrophic signals...
  36. ncbi Function of opioids in the enteric nervous system
    J D Wood
    Department of Physiology and Cell Biology, Ohio State University, Columbus, OH 43210, USA
    Neurogastroenterol Motil 16:17-28. 2004
    ..gastrointestinal functions reflect actions on electrical and synaptic behaviour of neurones in the enteric nervous system. Adverse effects and positive therapeutic effects of administration of opioid-receptor-blocking drugs on ..
  37. pmc Toll-like receptors 3, 4, and 7 are expressed in the enteric nervous system and dorsal root ganglia
    Isabella Barajon
    Department of Human Morphology and Biomedical Sciences, Città Studi, 20133 Milano, Italy
    J Histochem Cytochem 57:1013-23. 2009
    ....
  38. pmc Transplanted progenitors generate functional enteric neurons in the postnatal colon
    Ryo Hotta
    Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia
    J Clin Invest 123:1182-91. 2013
    Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases of the enteric nervous system. Many studies have demonstrated that various stem/progenitor cells can give rise to functional neurons in the ..
  39. ncbi Human and mouse enteric nervous system neurosphere transplants regulate the function of aganglionic embryonic distal colon
    Richard M Lindley
    Institute of Child Health, University of Liverpool, Royal Liverpool Children s Hospital, Alder Hey, Liverpool, United Kingdom
    Gastroenterology 135:205-216.e6. 2008
    Recent advances have raised the possibility of treating enteric nervous system (ENS) disorders with transplanted progenitor cells (ENSPC)...
  40. pmc Endoderm-derived Sonic hedgehog and mesoderm Hand2 expression are required for enteric nervous system development in zebrafish
    Bettina Reichenbach
    Department of Developmental Biology, University of Freiburg, Biology I, Hauptstrasse 1, 79104 Freiburg, Germany
    Dev Biol 318:52-64. 2008
    The zebrafish enteric nervous system (ENS), like those of all other vertebrate species, is principally derived from the vagal neural crest cells (NCC)...
  41. ncbi KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome
    David A Lyons
    Department of Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Development 135:599-608. 2008
    ..We propose that kbp is an important regulator of axonal development and that axonal cytoskeletal defects underlie the nervous system defects in GSS...
  42. ncbi GDNF availability determines enteric neuron number by controlling precursor proliferation
    Scott Gianino
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 130:2187-98. 2003
    To clarify the role of Ret signaling components in enteric nervous system (ENS) development, we evaluated ENS anatomy and intestinal contractility in mice heterozygous for Ret, GFRalpha1 and Ret ligands...
  43. ncbi Differentiation of neurospheres from the enteric nervous system
    Karl Herbert Schafer
    Department of Pediatric Surgery, University Hospital Mannheim, University of Heidelberg, Heidelberg, Germany
    Pediatr Surg Int 19:340-4. 2003
    The enteric nervous system (ENS) derives from neural crest cells, which migrate from the neural tube into the developing gut...
  44. ncbi Expansion and differentiation of neural progenitors derived from the human adult enteric nervous system
    Marco Metzger
    Translational Centre for Regenerative Medicine, University of Leipzig, Leipzig, Germany
    Gastroenterology 137:2063-2073.e4. 2009
    Neural stem and progenitor cells from the enteric nervous system have been proposed for use in cell-based therapies against specific neurogastrointestinal disorders...
  45. ncbi Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis
    Dipa Natarajan
    Division of Molecular Neurobiology, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK
    Development 129:5151-60. 2002
    The majority of neurones and glia of the enteric nervous system (ENS) are derived from the vagal neural crest...
  46. ncbi Evidence for neural progenitor cells in the human adult enteric nervous system
    Gaetano Azan
    Department of Neurology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Cell Tissue Res 344:217-25. 2011
    Putative neural stem cells have been identified within the enteric nervous system (ENS) of adult rodents and cultured from human myenteric plexus...
  47. ncbi Stem cells for GI motility disorders
    Ryo Hotta
    Department of Anatomy and Cell Biology, University of Melbourne, Victoria, Australia
    Curr Opin Pharmacol 11:617-23. 2011
    ..by conventional endoscopy, and in experimental transplantation studies appear capable of generating a neo-Enteric Nervous System. Current initiatives are addressing pre-clinical proof of concept studies in vivo utilising animal models ..
  48. pmc Balancing neural crest cell intrinsic processes with those of the microenvironment in Tcof1 haploinsufficient mice enables complete enteric nervous system formation
    Amanda J Barlow
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    Hum Mol Genet 21:1782-93. 2012
    The enteric nervous system (ENS) comprises a complex neuronal network that regulates peristalsis of the gut wall and secretions into the lumen...
  49. ncbi Development and developmental disorders of the enteric nervous system
    Florian Obermayr
    Department of Pediatric Surgery, University Children s Hospital, University of Tubingen, Hoppe Seyler Straße 3, Tubingen 72076, Germany
    Nat Rev Gastroenterol Hepatol 10:43-57. 2013
    The enteric nervous system (ENS) arises from neural crest-derived cells that migrate into and along the gut, leading to the formation of a complex network of neurons and glial cells that regulates motility, secretion and blood flow...
  50. pmc Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans
    Elly Sau Wai Ngan
    Department of Surgery, Li Ka Shing Faculty of Medicine, University of Hong Kong, Pokfulam, Hong Kong, China
    J Clin Invest 121:3467-78. 2011
    ..Dll1 integrated Hedgehog and Notch pathways to coordinate neuronal and glial cell differentiation during enteric nervous system development...
  51. pmc The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication
    P Bercik
    Department of Medicine, Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada
    Neurogastroenterol Motil 23:1132-9. 2011
    ..BDNF mRNA was measured in neuroblastoma SH-SY5Y cells after incubation with sera from B. longum- or placebo-treated mice. The effect of B. longum on myenteric neuron excitability was measured using intracellular microelectrodes...
  52. ncbi Targeting α-7 nicotinic acetylcholine receptor in the enteric nervous system: a cholinergic agonist prevents gut barrier failure after severe burn injury
    Todd W Costantini
    Division of Trauma, Surgical Critical Care, and Burns, Department of Surgery, University of California San Diego Health Sciences, San Diego, California, USA
    Am J Pathol 181:478-86. 2012
    ..Defining the interactions among the vagus nerve, the enteric nervous system, and the intestinal epithelium may lead to development of targeted therapeutics aimed at reducing gut ..
  53. ncbi Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors
    J J Wu
    Department of Anatomy and Cell Biology and Center for Neurobiology and Behavior, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    Development 126:1161-73. 1999
    ....
  54. pmc Behind an enteric neuron there may lie a glial cell
    Michael D Gershon
    Department of Pathology and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10128, USA
    J Clin Invest 121:3386-9. 2011
    The enteric nervous system (ENS) controls the gastrointestinal system. Enteric glia have long been regarded as the essential "glue" of the ENS...
  55. pmc Isolation and live imaging of enteric progenitors based on Sox10-Histone2BVenus transgene expression
    Jennifer C Corpening
    Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Genesis 49:599-618. 2011
    To facilitate dynamic imaging of neural crest (NC) lineages and discrimination of individual cells in the enteric nervous system (ENS) where close juxtaposition often complicates viewing, we generated a mouse BAC transgenic line that ..
  56. ncbi Development of enteric neuron diversity
    Marlene M Hao
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    J Cell Mol Med 13:1193-210. 2009
    The mature enteric nervous system (ENS) is composed of many different neuron subtypes and enteric glia, which all arise from the neural crest...
  57. ncbi Enteric nervous system stem cells derived from human gut mucosa for the treatment of aganglionic gut disorders
    Marco Metzger
    Gastroenterology, Institute of Child Health, University College London, London, United Kingdom
    Gastroenterology 136:2214-25.e1-3. 2009
    b>Enteric nervous system stem cells (ENSSCs) provide potential therapeutic tools to replenish absent ganglia in Hirschsprung's disease...
  58. ncbi Looking inside an invasion wave of cells using continuum models: proliferation is the key
    Matthew J Simpson
    Department of Mathematics and Statistics, University of Melbourne, VIC 3010, Australia
    J Theor Biol 243:343-60. 2006
    ..to investigate the migration of neural crest (NC) cells along the gut during the development of the enteric nervous system (ENS). The NC cells colonise the gastro-intestinal tract as a rostro-caudal wave...
  59. ncbi Isolation and cultivation of neuronal precursor cells from the developing human enteric nervous system as a tool for cell therapy in dysganglionosis
    Ulrich Rauch
    Department of Pediatric Surgery, Clinical Hospital Mannheim, University Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Int J Colorectal Dis 21:554-9. 2006
    The human enteric nervous system (ENS) descends from migrating neural crest cells (NCC) and is structured into different plexuses embedded in the gastrointestinal tract wall...
  60. ncbi Enteric nervous system development: Recent progress and future challenges
    Cátia Laranjeira
    MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, United Kingdom
    Auton Neurosci 151:61-9. 2009
    The enteric nervous system is the largest subdivision of the peripheral nervous system that plays a critical role in digestive functions...
  61. pmc Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms
    Thibaud Lebouvier
    UMR 913, INSERM, Nantes, France
    PLoS ONE 5:e12728. 2010
    The presence of Lewy bodies and Lewy neurites (LN) has been demonstrated in the enteric nervous system (ENS) of Parkinson's disease (PD) patients...
  62. ncbi Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts
    R P Kapur
    Department of Pathology, Children s Hospital, Seattle, Washington, USA
    Development 121:3787-95. 1995
    ..We have used expression of a transgene, dopamine-beta-hydroxylase-nlacZ, to study colonization of the enteric nervous system in sl/sl embryos and sl/sl <--> wild-type chimeric mice...
  63. pmc Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction
    Isabel Puig
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, Orsay, France
    J Clin Invest 119:3586-96. 2009
    ..is a benign proliferation of nerve ganglion cells, nerve fibers, and supporting cells of the enteric nervous system (ENS) that can result in abnormally large enteric neuronal cells (ENCs) in the myenteric plexus and ..
  64. ncbi Embryonic differentiation of serotonin-containing neurons in the enteric nervous system of the locust (Locusta migratoria)
    Michael Stern
    Cell Biology, Institute of Physiology, University of Veterinary Medicine Hannover, D 30173 Hannover, Germany
    J Comp Neurol 501:38-51. 2007
    The enteric nervous system (ENS) of the locust consists of four ganglia (frontal and hypocerebral ganglion, and the paired ingluvial ganglia) located on the foregut, and nerve plexus innervating fore- and midgut...
  65. pmc Expression of PROKR1 and PROKR2 in human enteric neural precursor cells and identification of sequence variants suggest a role in HSCR
    Macarena Ruiz-Ferrer
    Unidad de Gestión Clínica de Genética, Reproducción y Medicina Fetal, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío CSIC Universidad de Sevilla, Sevilla, Spain
    PLoS ONE 6:e23475. 2011
    The enteric nervous system (ENS) is entirely derived from neural crest and its normal development is regulated by specific molecular pathways...
  66. ncbi Transcriptional regulation of RET by Nkx2-1, Phox2b, Sox10, and Pax3
    Thomas Y Y Leon
    Division of Paediatric Surgery, Department of Surgery, The University of Hong Kong, Hong Kong SAR, China
    J Pediatr Surg 44:1904-12. 2009
    ..encodes a single-pass receptor whose proper expression and function are essential for the development of enteric nervous system. Mutations in RET regulatory regions are also associated with Hirschsprung disease (HSCR) (aganglionosis ..
  67. ncbi Acquisition of neuronal and glial markers by neural crest-derived cells in the mouse intestine
    Heather M Young
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Victoria, Australia
    J Comp Neurol 456:1-11. 2003
    ..5(+) nor S100b(+). Because some classes of neurons are not present in significant numbers until after birth, the expression of PGP9.5 by developing enteric neurons appeared to precede the expression of neuron type-specific markers...
  68. ncbi Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity
    Suzanne Bixby
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Neuron 35:643-56. 2002
    ..Upon transplantation of uncultured NCSCs into developing peripheral nerves in vivo, sciatic nerve NCSCs gave rise only to glia, while gut NCSCs gave rise primarily to neurons. Thus, cell fate in the nerve was stem cell determined...
  69. ncbi KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development
    Ruyun Zhou
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell 139:802-13. 2009
    ..We therefore propose that the unconventional kinesin KIF26A plays a key role in enteric nervous system development by repressing a cell growth signaling pathway.
  70. ncbi Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons
    S M Ward
    Department of Physiology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    J Neurosci 20:1393-403. 2000
    ..These data suggest that IC-IM play a major role in receiving cholinergic excitatory inputs from the enteric nervous system in the murine fundus.
  71. pmc Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
    Grant Anderson
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 207:4-12. 2007
    ..MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine), is a selective dopamine neuron toxin in the enteric nervous system (ENS)...
  72. ncbi Gut peristalsis is governed by a multitude of cooperating mechanisms
    Jan D Huizinga
    McMaster Univ, Health Science Center, Rm 3N8B, 1200 Main St West, Hamilton, ON L8N3Z5, Canada
    Am J Physiol Gastrointest Liver Physiol 296:G1-8. 2009
    ..All these systems together reliably perform the task of moving and mixing gut content to provide us with essential nutrients...
  73. pmc Fundamentals of neurogastroenterology
    J D Wood
    Departments of Physiology and Internal Medicine, The Ohio State University College of Medicine and Public Health, Columbus 43210, USA
    Gut 45:II6-II16. 1999
    ....
  74. ncbi Changes in the somatostatin (SOM)-like immunoreactivity within nervous structures of the porcine descending colon under various pathological factors
    Sławomir Gonkowski
    Division of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Olsztyn, Poland
    Exp Mol Pathol 88:416-23. 2010
    This study reports on changes in the somatostatin-like immunoreactive (SOM-LI) nerve structures of the enteric nervous system (ENS) in the porcine descending colon, caused by chemically driven inflammation, proliferative enteropathy (PE), ..
  75. ncbi Structural organization and neuropeptide distribution in the mammalian enteric nervous system, with special attention to those components involved in mucosal reflexes
    J P Timmermans
    Laboratory of Cell Biology and Histology, University of Antwerp RUCA, Belgium
    Comp Biochem Physiol A Physiol 118:331-40. 1997
    Gastrointestinal events such as peristalsis and secretion/absorption processes are influenced by the enteric nervous system, which is capable of acting largely independently from other parts of the nervous system...
  76. ncbi Neurogenic and myogenic motor patterns of rabbit proximal, mid, and distal colon
    P G Dinning
    Dept of Human Physiology, School of Medicine, Finders University, Bedford Park, SA 5042, Australia
    Am J Physiol Gastrointest Liver Physiol 303:G83-92. 2012
    ..The regional specificity motor pattern is likely to facilitate orderly transit of colonic content from semi-liquid to solid composition of feces...
  77. ncbi Enteric neuroplasticity evoked by inflammation
    Valentina Vasina
    Department of Pharmacology, University of Bologna, St Orsola Malpighi Hospital, Italy
    Auton Neurosci 126:264-72. 2006
    Neuroplastic changes in the enteric nervous system (ENS) may be observed in physiological states, such as development and aging, or occur as a consequence of different pathological conditions, ranging from enteric neuropathies (e.g...
  78. pmc Developmental biology of the enteric nervous system: pathogenesis of Hirschsprung's disease and other congenital dysmotilities
    Michael D Gershon
    Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, 630 West 268th Street, New York, NY 10032, USA
    Semin Pediatr Surg 13:224-35. 2004
  79. ncbi Distribution and chemical coding of intramural neurons in the porcine ileum during proliferative enteropathy
    Z Pidsudko
    Department of Functional Morphology, University of Warmia, Olsztyn, Oczapowskiego, Olsztyn, Poland
    J Comp Pathol 138:23-31. 2008
    ..However, further studies are required to determine the exact physiological relevance of the observed adaptive changes...
  80. ncbi Human hephaestin expression is not limited to enterocytes of the gastrointestinal tract but is also found in the antrum, the enteric nervous system, and pancreatic {beta}-cells
    David M Hudson
    Centre for Blood Research and Department of Biochemistry, University of British Columbia, Vancouver, Canada
    Am J Physiol Gastrointest Liver Physiol 298:G425-32. 2010
    ..Hp to the entire length of the gastrointestinal tract, the antral portion of the stomach, and to the enteric nervous system (both the myenteric and submucous plexi). Hp was also localized to human pancreatic beta-cells...
  81. ncbi Differences in the distribution and chemical coding between neurons in the inferior mesenteric ganglion supplying the colon and rectum in the pig
    Z Pidsudko
    Department of Animal Anatomy, Faculty of Veterinary Medicine, Warmia and Masuria University in Olsztyn, Poland
    Cell Tissue Res 303:147-58. 2001
    ....
  82. ncbi Hydrogen sulfide as a signaling molecule in the enteric nervous system
    M Jimenez
    Department of Cell Biology, Physiology and Immunology, Universitat Auto noma de Barcelona, Barcelona, Spain
    Neurogastroenterol Motil 22:1149-53. 2010
    ..These novel observations extend our understanding of the function of H₂S in the gastrointestinal tract...
  83. ncbi Neuronal connections between central and enteric nervous system in the locust, Locusta migratoria
    Peter Bräunig
    Entwicklungsbiologie und Morphologie der Tiere, Institut Biology II Zoologie, RWTH Aachen, Kopernikusstrasse 16, 52074, Aachen, Germany
    Cell Tissue Res 333:159-68. 2008
    ..located within the head ganglia, and even neurons in thoracic ganglia, project into the ganglia of the enteric nervous system. This indicates that the coordination between the central and enteric ganglia is much more complex than ..
  84. pmc Loss of enteric motor neurotransmission in the gastric fundus of Sl/Sl(d) mice
    Elizabeth A H Beckett
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV 89557, USA
    J Physiol 543:871-87. 2002
    ....
  85. pmc Diabetes and the enteric nervous system
    B Chandrasekharan
    Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Neurogastroenterol Motil 19:951-60. 2007
    ..The pathogenesis of altered GI functions in diabetes is multifactorial and the role of the enteric nervous system (ENS) in this respect has gained significant importance...
  86. pmc Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
    D P Poole
    Department of Surgery, University of California, San Francisco, CA, USA
    Neurogastroenterol Motil 22:814-25, e227-8. 2010
    ..Although BAs have well-known actions on motility and secretion, nothing is known about the localization and function of GpBAR1 in the gastrointestinal tract...
  87. pmc Genetic model system studies of the development of the enteric nervous system, gut motility and Hirschsprung's disease
    G Burzynski
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Neurogastroenterol Motil 21:113-27. 2009
    The enteric nervous system (ENS) is the largest and most complicated subdivision of the peripheral nervous system. Its action is necessary to regulate many of the functions of the gastrointestinal tract including its motility...
  88. ncbi Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    Sabine Buhner
    Human Biology, Technische Universitat Munchen, Freising, Germany
    Gastroenterology 137:1425-34. 2009
    ..Pathological features in irritable bowel syndrome (IBS) include alterations in mucosal cell content and mediator release that might alter signaling to nearby submucosal neurons...
  89. ncbi Inflammatory neuropathies of the enteric nervous system
    Roberto De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, St Orsola Malpighi Hospital, Via Massarenti 9, I 40138 Bologna, Italy
    Gastroenterology 126:1872-83. 2004
    Inflammatory neuropathy of the enteric nervous system is emerging as an important topic in the field of neurogastroenterology. Enteric ganglionitis can be either primary or secondary to a wide array of diseases (i.e...
  90. ncbi Starring roles for astroglia in barrier pathologies of gut and brain
    Tor C Savidge
    Department of Gastroenterology and Hepatology, Division of Internal Medicine, The University of Texas Medical Branch, Galveston, TX 77555, USA
    Lab Invest 87:731-6. 2007
    ..Although most considerations of the enteric nervous system have focused on neuronal dysfunction, a large population of astrocyte-like glia populates gut muscle ..
  91. pmc Innervation of the gastrointestinal tract: patterns of aging
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Auton Neurosci 136:1-19. 2007
    ..These dramatic and consistent patterns of neuropathy that characterize the aging autonomic nervous system of the GI tract are candidate mechanisms for some of the age-related declines in function evidenced in the elderly...
  92. ncbi Role of neuropeptides in inflammatory bowel disease
    Kara J Gross
    Gastrointestinal Neuropeptide Center, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Inflamm Bowel Dis 13:918-32. 2007
    ..In the past several years the enteric nervous system (ENS) has been implicated in the pathophysiology of IBD...
  93. ncbi NTF-3, a gene involved in the enteric nervous system development, as a candidate gene for Hirschsprung disease
    Macarena Ruiz-Ferrer
    Unidad Clínica de Genética y Reproducción, Hospitales Universitarios Virgen del Rocio, 41013 Seville, Spain
    J Pediatr Surg 43:1308-11. 2008
    ..caused by a failure of neural crest cells to migrate, proliferate, and/or differentiate during the enteric nervous system (ENS) development...
  94. pmc Role of nerves in enteric infection
    R C Spiller
    Division of Gastroenterology, University Hospital, Nottingham, UK
    Gut 51:759-62. 2002
    ..As our understanding of the role of nerves increases, exciting new targets for therapeutic intervention will emerge in both acute and chronic disorders induced by enteric infection...
  95. ncbi Critical numbers of neural crest cells are required in the pathways from the neural tube to the foregut to ensure complete enteric nervous system formation
    Amanda J Barlow
    Neural Development Unit, UCL Institute of Child Health, London, UK
    Development 135:1681-91. 2008
    The enteric nervous system (ENS) is mainly derived from vagal neural crest cells (NCC) that arise at the level of somites 1-7...
  96. ncbi Enteric nervous system
    David Grundy
    Department of Biomedical Science, University of Sheffield, Sheffield, UK
    Curr Opin Gastroenterol 22:102-10. 2006
    ..Our aim was to provide a synopsis of how the field of enteric neurobiology has advanced during the past year...
  97. ncbi New insights into human enteric neuropathies
    R De Giorgio
    Department of Internal Medicine and Gastroenterology, University of Bologna, Bologna, Italy
    Neurogastroenterol Motil 16:143-7. 2004
    ..Evidence is now gathering to explain how dysfunction of the enteric nervous system (ENS) may lead to human gastrointestinal motor disorders...
  98. ncbi In vitro formation of enteric neural network structure in a gut-like organ differentiated from mouse embryonic stem cells
    Miyako Takaki
    Department of Physiology II, Nara Medical University, School of Medicine, Kashihara, Japan
    Stem Cells 24:1414-22. 2006
    ..first time succeeded in in vitro formation of enteric neural ganglia with connecting nerve fiber tracts (enteric nervous system [ENS]) in the ES gut. The ES gut with ENS exhibited strong peristalsis-like movements...
  99. ncbi Notch signaling is required for the maintenance of enteric neural crest progenitors
    Yoshiaki Okamura
    Department of Genetics, SOKENDAI, 1111 Yata, Mishima, Shizuoka 411 8540, Japan
    Development 135:3555-65. 2008
    ..NCC-specific Pofut1-knockout mice died within 1 day of birth, accompanied by a defect of enteric nervous system (ENS) development...
  100. ncbi Types of neurons in the enteric nervous system
    J B Furness
    Department of Anatomy and Cell Biology, University of Melbourne, VIC 3010, Parkville, Australia
    J Auton Nerv Syst 81:87-96. 2000
    ..by Professor Geoffrey Burnstock, highlights the progress made in understanding the organisation of the enteric nervous system over this time...
  101. ncbi Neural crest and the development of the enteric nervous system
    Richard B Anderson
    Department of Anatomy and Cell Biology, University of Melbourne, 3010, Vic, Australia
    Adv Exp Med Biol 589:181-96. 2006
    The formation of the enteric nervous system (ENS) is a particularly interesting example of the migratory ability of the neural crest and of the complexity of structures to which neural crest cells contribute...

Research Grants64

  1. Human embryonic stem cell-derived neural crest stem cells and Hirschsprung disea
    Sean J Morrison; Fiscal Year: 2010
    ..is a congenital defect that affects 1 out of 5,000 live births and is characterized by a failure to form enteric nervous system (ENS) in a variable length of the hindgut ADDIN EN...
  2. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..GI) tract (although inhalation exposing the olfactory nerves is also possible), suggesting that the enteric nervous system (ENS), which would be on the front lines of exposure to these environmental agents, might be affected ..
  3. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    John R Grider; Fiscal Year: 2013
    ..the neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in the physiology and pathophysiology of the enteric nervous system (ENS) with regard to the regulation of the peristaltic reflex...
  4. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..reported that early life stressors can lead to enhanced responsiveness of serotoninergic pathway in enteric nervous system. Theoretically, visceral hyperalgesia and irritable bowel syndrome may be treated by reversal or ..
  5. Epigenetic regulation of stem cell senescence in aging
    DAVID TOCHUKWU ASUZU; Fiscal Year: 2011
    ..dysfunction was believed to be the major contributor to age-related GI problems due to degeneration of the enteric nervous system and smooth muscles. However, little is known of age-related changes to ICC, the pacemaker cells of the gut...
  6. Ibuprofen and enteric neural crest precursor migration
    ELLEN MERRICK; Fiscal Year: 2013
    ..Hirschsprung Disease (HSCR) is a birth defect of the enteric nervous system that occurs when enteric neural crest-derived cells (ENCCs) do not migrate all the way to the end of the ..
  7. Integration of mucosal immune responses through the enteric nervous system
    DANIEL S MUCIDA; Fiscal Year: 2013
    ..The enteric nervous system (ENS) is organized in several plexuses throughout the intestinal wall...
  8. Route of Nutrition and Enteric Nervous System Effects on Innate Mucosal Defense
    Kenneth A Kudsk; Fiscal Year: 2013
    ..we discovered defects in innate mucosal defenses and tracked these defects to failure to stimulate the enteric nervous system (ENS)...
  9. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): This project will investigate interactive signaling between the enteric nervous system (ENS), spinal sensory afferent innervation and enteric mast cells with guinea pig small intestine as the ..
  10. ROLE OF GUT PEPTIDES IN INTESTINAL PERISTALSIS
    JOHN GRIDER; Fiscal Year: 2009
    ..the neurotrophin, Brain Derived Neurotrophic Factor (BDNF), in the physiology and pathophysiology of the enteric nervous system (ENS) with regard to the regulation of the peristaltic reflex...
  11. Enteric Neuronal Development as a Determinant of Intestinal Inflammation
    Kara Gross Margolis; Fiscal Year: 2013
    ..My investigation is designed to analyze putative contributions of the enteric nervous system (ENS) to the pathophysiology of intestinal inflammation and neuroimmune interactions in the bowel wall...
  12. Sox10 Alleles for Functional Analysis of Glial Lineages
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..in the central nervous system as well as neural crest- derived Schwann cells, satellite glia and enteric nervous system neurons and glia in the periphery...
  13. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The enteric nervous system plays a critical role in normal function of the intestine...
  14. Regulation of gastrointestinal neuromuscular function by NIBP/NFkB signaling
    Wenhui Hu; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The enteric nervous system (ENS) plays an important role in the regulation of gastrointestinal (GI) functions...
  15. Ednrb Regulation of Gastrointestinal Motility
    KENT CHARLES WILLIAMS; Fiscal Year: 2013
    ..Aim 3 investigate how Ednrb that is expressed by the enteric nervous system and intestinal smooth muscle interact in the regulation of intestinal smooth muscle activity...
  16. Characterization of neural crest stem cells in human hair follicles.
    Xiaowei Xu; Fiscal Year: 2013
    ..pluripotent and NCSCs have been shown to persist in the adult in at least two differentiated tissues, the enteric nervous system of the gut and the skin and hair follicles. Hair follicles are a niche for NCSCs in the skin...
  17. MICROENVIRONMENT IN ENTERIC NEURON DEVELOPMENT
    Michael D Gershon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The enteric nervous system (ENS) is remarkable for its phenotypic diversity and regulation of complex enteric behaviors independently of CNS input...
  18. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The enteric nervous system (ENS) is large, complex, and capable of integrative neuronal activity. Unlike the CNS, however, the ENS is relatively exposed in the abdomen to injury...
  19. Genetic Complexity and Modifiers of Hirschsprung Disease
    E Michelle Southard-Smith; Fiscal Year: 2011
    ..clinical feature, aganglionic megacolon, arises as a consequence of anomalies in development of the enteric nervous system and subsequent absence of enteric ganglia...
  20. Enteric nervous system deficits in Hirschsprung ganglionic bowel
    MELISSA MUSSER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Coordinated communication between the enteric nervous system (ENS) and other tissue types is necessary for regular function and motility of the intestine...
  21. VZV in the enteric nervous system: pathogenesis and consequences
    Michael D Gershon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The enteric nervous system (ENS) can control the behavior of the bowel without input from brain or spinal cord...
  22. Gdnf and endothelin-3 regulate colorectal enteric nervous system development
    Allan M Goldstein; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The enteric nervous system (ENS) is a complex network of neurons and glia present in the bowel wall and critical for regulating intestinal motility...
  23. Regulation of Intestinal PYY cell function
    Diego V Bohórquez; Fiscal Year: 2013
    ..data developed by the applicant that show that L cells have an intimate relationship with elements of the enteric nervous system. The rationale is that by defining the function and regulation of basal processes new approaches can be ..
  24. Roles of DNA methylation in gastrointestinal smooth muscle cells
    Seungil Ro; Fiscal Year: 2013
    ..are characterized by dysfunctions of three types of key cells: interstitial cels of Cajal (ICC), enteric nervous system (ENS), and smooth muscle cells (SMCs), which cooperatively control SM motility in the GI tract...
  25. Formation of the Enteric Nervous System
    Chen Ming Fan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neurons of the enteric nervous system (ENS), i.e. the enteric neurons, are located within the gastrointestinal (GI) tract, pancreas, and gall bladder...
  26. Genes, Environment &Neural Stem Cell Transplantation in the Gut
    Pankaj J Pasricha; Fiscal Year: 2012
    ..initially focused on the most well characterized pathway responsible for the normal development of the enteric nervous system, glial derived neurotrophic factor or GDNF, and its cognate receptor, RET...
  27. Analysis of Ret signaling in Drosophila enteric nervous system development.
    Thomas Kidd; Fiscal Year: 2011
    ..spinal cord and subsequently migrate to populate the entire length of the digestive tract, forming the enteric nervous system (ENS)...
  28. Purinergic neurotransmission in the gut
    James J Galligan; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The enteric nervous system (ENS) is the division of the autonomic nervous system that resides within the gut wall. The ENS controls gastrointestinal (GI) motility, secretion and local blood flow...
  29. Signaling Hierarchies in Vertebrate Development
    Judith S Eisen; Fiscal Year: 2013
    ..Hirschsprung disease, the leading cause of intestinal aganglionosis, exploring the hypothesis that the enteric nervous system regulates composition of intestinal bacterial communities and that altered communities contribute to ..
  30. Roles of the microbiota and Notch signaling in specifying cell fate
    Joshua V Troll; Fiscal Year: 2011
    ..that Notch signaling mediates microbiota-directed intestinal development in the both the epithelium and enteric nervous system. Objective: This proposal will explore the hypothesis that Notch signaling mediates microbiota- directed ..
  31. Role of Endothelin Receptor B signaling in the genesis of aganglionic megacolon
    Miles L Epstein; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The enteric nervous system (ENS) develops primarily from a cohort of neural crest- derived cells (ENCCs) that enter at the pharynx before advancing caudally through the developing gut...
  32. Generating Human Intestinal Organoids with an ENS.
    James M Wells; Fiscal Year: 2013
    ..However, due to lack of an enteric nervous system in HIOs, the system is not a useful platform to study GI motility disorders...
  33. MOLECULAR MECHANISMS OF INTESTINAL TRANSPORT
    Ernest M Wright; Fiscal Year: 2013
    ..properties between the brush border Na/glucose cotransport and the glucosensor (SGLT3) found in the enteric nervous system. The results will also provide a structural basis for the interaction of natural products in our diet with ..
  34. Analysis of HSCR patient exome sequence data using Zebrafish
    Iain T Shepherd; Fiscal Year: 2013
    ..HSCR is a pediatric condition where the enteric nervous system (ENS) fails to form properly...
  35. Mechanisms of modifier effects on aganglionosis in the Sox10Dom model of HSCR
    LAUREN WALTERS; Fiscal Year: 2010
    ..portion of the distal colon due to deficits in the neural crest stem cells (NCSC) that give rise to the enteric nervous system. HSCR is a prime example of a complex genetic disease...
  36. In Vivo Analysis of the Mechanisms of Neural Crest Migration
    Paul Kulesa; Fiscal Year: 2012
    ..cell-like population that contribute to craniofacial and cardiovascular development, and peripheral and enteric nervous system assembly...
  37. Identification of agents to enhance colonic motility in the elderly
    Michael A Pack; Fiscal Year: 2012
    ..Current treatment for constipation involves increasing stool water and enhancing enteric nervous system mediated colonic motility...
  38. A Physiological Role of Gastrin Releasing Peptide in the Control of Meal Size
    Ayman I Sayegh; Fiscal Year: 2013
    ..3) The enteric nervous system of the gastrointestinal tract has a role in the regulation of meal size by GRP...
  39. Nervous system regeneration, molecular basis in echinoderms
    JOSE E GARCIA-ARRARAS; Fiscal Year: 2013
    ..This species can regenerate both its radial nerve cord and enteric nervous system in a process that includes re-growth of nerve fibers and neurogenesis...
  40. A Murine Sox10 Dominant Negative COIN Allele for Functional Gene Analysis
    E Michelle Southard-Smith; Fiscal Year: 2013
    ..in the central nervous system as well as neural crest-derived Schwann cells, satellite glia and enteric nervous system neurons and glia in the periphery...
  41. The effect of bariatric surgery on carbohydrate metabolism
    Adrian Vella; Fiscal Year: 2013
    ..secretion is affected by the rate of intestinal delivery of calories and may also be modulated by the enteric nervous system and the rate of direct delivery of nutrients to enteroendocrine cells...
  42. Placode lineage contribution to Hirschsprung's disease
    Takako Makita; Fiscal Year: 2013
    ..Neural cres is responsible for formation of the enteric nervous system, and their absence results in an aganglionic segment in the terminal bowel, which results in a failure to ..
  43. WATER AND ELECTROLYTE TRANSPORT BY THE INTESTINE
    KENNETH HUBEL; Fiscal Year: 1990
    Studies are proposed in Part I to determine the influence of the enteric nervous system on the transport of electrolytes and water by the small and large intestine of rabbit...
  44. Quiescent Dclk1+ stem cells in the mouse intestine
    TIMOTHY CRAGIN WANG; Fiscal Year: 2012
    ..cells that originate from the neural crest, and that Dclk1 also labels extraganglionic progenitors of the enteric nervous system. Our hypothesis is that Dclk1+ stem cells play a role both as neural stem cells and also as reserve ..
  45. ABNORMAL TERMINAL COLON OF THE 1S/1S MUTANT MOUSE
    TAUBE ROTHMAN; Fiscal Year: 2000
    The enteric nervous system (ENS) is formed by cells that migrate from the neural crest. Once they reach the gut their differentiation is influenced by signals from the microenvironment, specifically, the extracellular matrix (ECM)...
  46. mu Opioid Receptor Function in the Enteric Nervous System
    Catia Sternini; Fiscal Year: 2007
    ..abstract_text> ..
  47. SYNAPTIC TRANSMISSION IN DIABETIC ENTERIC NERVOUS SYSTEM
    KATHY LEPARD; Fiscal Year: 2001
    ....
  48. GDNF in the Enteric Nervous System
    Yun Xia; Fiscal Year: 2007
    ..The focus in this proposal on the enteric nervous system as a "brain-in-the-gut" addresses an important aspect of neurogastroenterology that is related to ..
  49. NEURAL CONTROL OF THE GALLBLADDER
    Gary Mawe; Fiscal Year: 1992
    ..the structure of the ganglionated plexus of the gallbladder is analogous to that of the gut (the enteric nervous system (ENS) has a unique structure and chemistry, which reflect an ability to mediate reflex activity ..
  50. ETHANOL MODULATION OF ENTERIC NEUROTRANSMISSION
    Terence Smith; Fiscal Year: 2000
    ..I.'s preliminary studies suggest that a more sensitive target is the enteric nervous system (ENS) within the gut wall...
  51. NEUROPEPTIDE CONTROL OF ENTERIC SPHINCTERS
    James Reynolds; Fiscal Year: 1990
    The enteric nervous system mediates sphincteric reflexes, peristalsis and many other gut functions. Most intrinsic, enteric nerves contain peptide neurotransmitters...
  52. SPINAL & BRAIN MODULATION OF GASTROINTESTINAL MOTILITY
    Frank Porreca; Fiscal Year: 1992
    ..Neuropeptides can act at a discrete sites in affecting GI motor function: the brain the neurons of the enteric nervous system, the smooth muscle of the gut, and, as only very recently demonstrated, the spinal cord...
  53. Acetylcholine in Diabetic Enteric Nervous System
    KATHY LEPARD; Fiscal Year: 2004
    ..Once these adaptations are understood, GI complications experienced by diabetic patients can be more effectively treated. ..
  54. MECHANISMS OF SLOW SYNAPTIC EXCITATION IN ENTERIC NERVES
    James Galligan; Fiscal Year: 1999
    Slow excitatory synaptic transmission is a mechanism of neural communication in the enteric nervous system and is likely to participate in the regulation of gut motility...
  55. Sox10 in Development of the Enteric Nervous System
    E Southard Smith; Fiscal Year: 2004
    Congenital gastrointestinal motility disorders arise as a consequence of anomalies in development of the enteric nervous system (ENS)...
  56. DEVELOPMENT OF NEURONS IN GUT--GROWTH FACTORS
    MILES EPSTEIN; Fiscal Year: 2001
    ..The long-term objective of this study is to elucidate the mechanisms which regulate the formation of the enteric nervous system. The formation and maintenance of the enteric nervous system are essential to the formal function of the ..
  57. REGULATION OF GENE EXPRESSION IN THE SMALL INTESTINE
    Jeffrey Gordon; Fiscal Year: 2005
    ..fortification of the mucosal barrier, xenobiotic metabolism, angiogenesis, plus genes associated with the enteric nervous system)...
  58. EFFECTS OF CONDITIONING ON MUCOSAL IMMUNOPHYSIOLOGY
    Mary Perdue; Fiscal Year: 1993
    ..only causes abnormalities of immune cells, but also of neurons of the central nervous system (CNS) and the enteric nervous system (ENS). Psychological factors (via the CNS) can influence the course and symptoms of immune diseases...
  59. Spectrum of Autoimmune Gastrointestinal Dysmotility
    Vanda Lennon; Fiscal Year: 2009
    ..I.) dysmotility. Autoimmunity targeting neurons in ganglia of the enteric nervous system (ENS), and extrinsic autonomic ganglia, is well-documented clinically in association with lung cancer, and ..
  60. ENTERIC NEURON ABLATION; ALTERED MOTILITY AND SECRETION
    Paul Bass; Fiscal Year: 1990
    Our objective is to understand the role of the enteric nervous system, which consists of the myenteric and submucosal plexuses, in the control of intestinal motility and mucosal transport...
  61. Little Brain Big Brain Meeting
    David Linden; Fiscal Year: 2009
    ..attend and will cover the breadth of study in the field of neurogastroenterology, from development of the enteric nervous system to epidemiology of digestive diseases...
  62. MECHANISM OF GI MOTOR DISTURBANCES IN ENTERIC PARASITISM
    Jeffrey Palmer; Fiscal Year: 1991
    ..The long-term objective of this project is to elucidate the role of the enteric nervous system in the onset and maintenance of alterations of intestinal motor patterns during enteric parasitic ..
  63. PANCREATIC AND ENTERIC NEUROTRANSMISSION BY GLUTAMATE
    Annette Kirchgessner; Fiscal Year: 2001
    DESCRIPTION: The enteric nervous system (ENS) is the only region of the peripheral nervous system (PNS) that is intrinsically capable of mediating reflect activity...
  64. Development of Zebrafish Enteric Nervous System and Intestinal Smooth Muscle
    KENNETH WALLACE; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): The enteric nervous system plays a critical role in normal function of the intestine...