peripheral nervous system

Summary

Summary: The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.

Top Publications

  1. ncbi The neuropathic pain triad: neurons, immune cells and glia
    Joachim Scholz
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 10:1361-8. 2007
  2. ncbi Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    R Nolo
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 102:349-62. 2000
  3. ncbi Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system
    Shannon D Shields
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
    Pain 153:2017-30. 2012
  4. pmc Insulin-like growth factors in the peripheral nervous system
    Kelli A Sullivan
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Endocrinology 149:5963-71. 2008
  5. ncbi Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research
    Katrin Martens
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K U Leuven, Leuven, Belgium
    FEBS Lett 584:1054-8. 2010
  6. pmc Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
    Isaac M Chiu
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 15:1063-7. 2012
  7. pmc Acute injury in the peripheral nervous system triggers an alternative macrophage response
    Elke Ydens
    Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Antwerpen, Belgium
    J Neuroinflammation 9:176. 2012
  8. ncbi Migration and function of a glial subtype in the vertebrate peripheral nervous system
    Darren T Gilmour
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tubingen, Germany
    Neuron 34:577-88. 2002
  9. pmc In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration
    Florence M Bareyre
    Research Unit Therapy Development, Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 108:6282-7. 2011
  10. ncbi Spread of classic BSE prions from the gut via the peripheral nervous system to the brain
    Martin Kaatz
    Institute for Novel and Emerging Infectious Diseases, Friedrich Loeffler Institute, Greifswald Isle of Riems, Germany
    Am J Pathol 181:515-24. 2012

Detail Information

Publications332 found, 100 shown here

  1. ncbi The neuropathic pain triad: neurons, immune cells and glia
    Joachim Scholz
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nat Neurosci 10:1361-8. 2007
    ....
  2. ncbi Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila
    R Nolo
    Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 102:349-62. 2000
    ..The senseless (sens) gene is required for proper development of most cell types of the embryonic and adult peripheral nervous system (PNS) of Drosophila...
  3. ncbi Nav1.8 expression is not restricted to nociceptors in mouse peripheral nervous system
    Shannon D Shields
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
    Pain 153:2017-30. 2012
    ..8 in the peripheral nervous system. We demonstrate that 75% of dorsal root ganglion (DRG) neurons express Na(v)1...
  4. pmc Insulin-like growth factors in the peripheral nervous system
    Kelli A Sullivan
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 2200, USA
    Endocrinology 149:5963-71. 2008
    ..of IGF-I and -II, IGF-IR, and IGF binding proteins are developmentally regulated in the central and peripheral nervous system. IGF-I therapy demonstrates mixed therapeutic results in the treatment of peripheral nerve injury, ..
  5. ncbi Ectopic recombination in the central and peripheral nervous system by aP2/FABP4-Cre mice: implications for metabolism research
    Katrin Martens
    Laboratory of Cell Metabolism, Department of Pharmaceutical Sciences, K U Leuven, Leuven, Belgium
    FEBS Lett 584:1054-8. 2010
    ..In particular, Cre activity was found in ganglia of the peripheral nervous system (PNS), in adrenal medulla and in neurons throughout the central nervous system (CNS)...
  6. pmc Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology
    Isaac M Chiu
    FM Kirby Neurobiology Center, Children s Hospital Boston, Boston, Massachusetts, USA
    Nat Neurosci 15:1063-7. 2012
    ..of the same molecular recognition pathways for danger as immune cells, and, in response to danger, the peripheral nervous system directly communicates with the immune system, forming an integrated protective mechanism...
  7. pmc Acute injury in the peripheral nervous system triggers an alternative macrophage response
    Elke Ydens
    Peripheral Neuropathy Group, Department of Molecular Genetics, VIB and University of Antwerp, Antwerpen, Belgium
    J Neuroinflammation 9:176. 2012
    ..To unravel the neuroprotective aspects of the immune system we focused on a model of acute peripheral nerve injury, in which the immune system was shown to be protective...
  8. ncbi Migration and function of a glial subtype in the vertebrate peripheral nervous system
    Darren T Gilmour
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Spemannstrasse 35, 72076 Tubingen, Germany
    Neuron 34:577-88. 2002
    ..Furthermore, mutations in the transcription factor Sox10/cls uncouple the migration of axons and glia. Finally, genetic ablation of this glial subtype reveals an essential role in nerve fasciculation...
  9. pmc In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration
    Florence M Bareyre
    Research Unit Therapy Development, Institute of Clinical Neuroimmunology, Ludwig Maximilians Universitat Munchen, 81377 Munich, Germany
    Proc Natl Acad Sci U S A 108:6282-7. 2011
    In the peripheral nervous system (PNS), damaged axons regenerate successfully, whereas axons in the CNS fail to regrow...
  10. ncbi Spread of classic BSE prions from the gut via the peripheral nervous system to the brain
    Martin Kaatz
    Institute for Novel and Emerging Infectious Diseases, Friedrich Loeffler Institute, Greifswald Isle of Riems, Germany
    Am J Pathol 181:515-24. 2012
    ..In summary, our results decipher the centripetal spread of BSE prions along the autonomic nervous system to the central nervous system, starting already halfway in the incubation time...
  11. pmc The peripheral nervous system supports blood cell homing and survival in the Drosophila larva
    Kalpana Makhijani
    Department of Cell and Tissue Biology, University of California San Francisco, 35 Medical Center Way, San Francisco, CA 94143 0669, USA
    Development 138:5379-91. 2011
    ..larval hematopoiesis as the first Drosophila model for hematopoietic colonization and the role of the peripheral nervous system (PNS) as a microenvironment in hematopoiesis...
  12. ncbi Immune circuitry in the peripheral nervous system
    Bernd C Kieseier
    Department of Neurology, Heinrich Heine University, Dusseldorf, Germany
    Curr Opin Neurol 19:437-45. 2006
    The aim of this review is to describe the local immune circuitry in the peripheral nervous system and its dialogue with systemic immunity under pathological conditions...
  13. ncbi Molecular mechanisms regulating myelination in the peripheral nervous system
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Zurich, Zurich, Switzerland
    Trends Neurosci 35:123-34. 2012
    ..Oligodendrocytes in the central nervous system (CNS) and Schwann cells (SCs) in the peripheral nervous system (PNS) wrap their plasma membranes around axons to organize myelinated nerve fibers that allow rapid ..
  14. pmc Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system
    Diego Alvarez de la Rosa
    Departments of Cellular and Molecular Physiology, and Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 99:2326-31. 2002
    ..These functional properties and localization in DRG have profound implications for the putative functional roles of ASICs in the nervous system...
  15. ncbi Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins
    R J Giger
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Neuron 25:29-41. 2000
    ..Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections...
  16. ncbi The GDNF family ligands and receptors - implications for neural development
    R H Baloh
    Departments of Pathology and Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Neurobiol 10:103-10. 2000
    ..The results of such analyses reveal numerous similarities and potential overlaps in the way the GDNF and the nerve growth factor (NGF) families regulate development of the peripheral nervous system.
  17. pmc Reconstitution of the central and peripheral nervous system during salamander tail regeneration
    Levan Mchedlishvili
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 109:E2258-66. 2012
    ..cord tissue and nonclonal neurospheres, we show that the central spinal cord represents a source of peripheral nervous system cells. Interestingly, melanophores migrate from preexisting precursors in the skin...
  18. pmc Early diagnosis of peripheral nervous system involvement in Fabry disease and treatment of neuropathic pain: the report of an expert panel
    Alessandro P Burlina
    Neurological Unit, St Bassiano Hospital, Bassano del Grappa, Italy
    BMC Neurol 11:61. 2011
    ..Patients with Fabry disease often remain undiagnosed until severe complications involving the kidney, heart, peripheral nerves and/or brain have arisen...
  19. pmc Formation of the ascidian epidermal sensory neurons: insights into the origin of the chordate peripheral nervous system
    Andrea Pasini
    Institut de Biologie du Developpement de Marseille Luminy IBDML, UMR6216, CNRS Université de la Méditerranée, Marseille, France
    PLoS Biol 4:e225. 2006
    The vertebrate peripheral nervous system (PNS) originates from neural crest and placodes. While its developmental origin is the object of intense studies, little is known concerning its evolutionary history...
  20. ncbi A peripheral nervous system actin-binding protein regulates neurite outgrowth
    Samantha J Ravenall
    Department of Biology, University College, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 15:281-90. 2002
    ..These data suggest that Pervin may play a significant role in regulating process outgrowth in peripheral neurons through a mechanism that involves the activity of an actin-bundling domain...
  21. ncbi Effect of short-and long-term gonadectomy on neuroactive steroid levels in the central and peripheral nervous system of male and female rats
    D Caruso
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Milano, Italy
    J Neuroendocrinol 22:1137-47. 2010
    ..plasma levels; (ii) long-term gonadectomy induces changes in the levels of neuroactive steroids in the peripheral nervous system (PNS) and the CNS that, in some cases, are different to those induced by short-term gonadectomy; (iii) ..
  22. ncbi Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development
    J K Morris
    The Salk Institute, La Jolla, California 92037, USA
    Neuron 23:273-83. 1999
    ..However, these clusters are dispersed and morphologically different from those in control muscle. Our results reveal an important role for erbB2 during normal peripheral nervous system development.
  23. ncbi The role of macrophages in immune-mediated damage to the peripheral nervous system
    R Kiefer
    Department of Neurology, Westfalische Wilhelms Universitat, Albert Schweitzer Strasse 33, D 48129 Munster, Germany
    Prog Neurobiol 64:109-27. 2001
    ..Macrophages, thus, play dual roles in autoimmune neuropathy, being detrimental in attacking nervous tissue but also salutary, when aiding in the termination of the inflammatory process and the promotion of recovery...
  24. pmc Neuregulin-1 type III determines the ensheathment fate of axons
    Carla Taveggia
    Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:681-94. 2005
    ..These results indicate that levels of NRG1 type III, independent of axon diameter, provide a key instructive signal that determines the ensheathment fate of axons...
  25. pmc Reduced BACE1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system
    Mohamed H Farah
    Departments of Neurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 31:5744-54. 2011
    ..These observations were reproduced in part by pharmacological inhibition of BACE1. These data suggest BACE1 inhibition as a therapeutic approach to accelerate regeneration and recovery after peripheral nerve damage...
  26. ncbi Molecular domains of myelinated axons in the peripheral nervous system
    James L Salzer
    Department of Cell Biology and Neurology, and the Smilow Neuroscience Program, NYU School of Medicine, New York, New York 10016, USA
    Glia 56:1532-40. 2008
    ..This domain organization is essential for action potential propagation by saltatory conduction and for the overall function and integrity of the axon...
  27. ncbi Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation
    Guido Stoll
    Department of Neurology, Julius Maximilians Universitat, Wurzburg, Germany
    J Peripher Nerv Syst 7:13-27. 2002
    ..Similarities and differences between the PNS and CNS in terms of inflammation and microglial activation after nerve injury are discussed, and point towards progress in understanding the failure of nerve fiber regeneration in the CNS...
  28. pmc Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes
    Lucy M Hinder
    Department of Neurology, University of Michigan, AATBSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109 2200, USA
    J Endocrinol 216:1-11. 2013
    ....
  29. ncbi The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system
    M L Huang
    Institute of Neuroscience, National Yang Ming University, Taipei, Taiwan
    Neuron 25:57-67. 2000
    In the Drosophila peripheral nervous system, proneural genes direct the formation of different types of sensory organs. Here, we show that amos is a novel proneural gene that promotes multiple dendritic (MD) neuron formation...
  30. pmc Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
    Isaac M Chiu
    Program in Cellular and Molecular Medicine, Immune Disease Institute, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 106:20960-5. 2009
    ..However, the role of innate immunity in the peripheral nervous system (PNS) has not been well defined...
  31. ncbi Transcriptional regulation of the peripheral nervous system in Ciona intestinalis
    W Joyce Tang
    Department of Biology, San Diego State University, 5500 Campanile Drive, San Diego, CA 92182, USA
    Dev Biol 378:183-93. 2013
    The formation of the sensory organs and cells that make up the peripheral nervous system (PNS) relies on the activity of transcription factors encoded by proneural genes (PNGs)...
  32. pmc DNA damage response in peripheral nervous system: coping with cancer therapy-induced DNA lesions
    Ella W Englander
    Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA
    DNA Repair (Amst) 12:685-90. 2013
    In the absence of blood brain barrier (BBB) the DNA of peripheral nervous system (PNS) neurons is exposed to a broader spectrum of endogenous and exogenous threats compared to that of the central nervous system (CNS)...
  33. ncbi Role of integrins in the peripheral nervous system
    S C Previtali
    Department of Neurosciences and DIBIT, S Raffaele Scientific Institute, Via Olgettina 58, 20132 Milan, Italy
    Prog Neurobiol 64:35-49. 2001
    ..Differential expression of integrins is developmentally regulated in the peripheral nervous system (PNS) and is associated with crucial events in both physiological and pathological processes...
  34. pmc Disruption of laminin in the peripheral nervous system impedes nonmyelinating Schwann cell development and impairs nociceptive sensory function
    Wei Ming Yu
    Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY, USA
    Glia 57:850-9. 2009
    ..These results show that laminin participates in nonmyelinating SC development and Remak bundle formation and suggest a possible role for laminin deficiency in peripheral sensory neuropathies...
  35. ncbi Severe hypoxia affects exercise performance independently of afferent feedback and peripheral fatigue
    Guillaume Y Millet
    School of Exercise and Health Sciences, Edith Cowan University, Joondalup, Australia
    J Appl Physiol (1985) 112:1335-44. 2012
    ..It is concluded that submaximal performance in SevHyp is partly reduced by a mechanism related directly to brain oxygenation...
  36. pmc Peripheral nervous system function and organophosphate pesticide use among licensed pesticide applicators in the Agricultural Health Study
    Sarah E Starks
    Department of Occupational and Environmental Health, University of Iowa, Iowa City, Iowa 52242 5000, USA
    Environ Health Perspect 120:515-20. 2012
    Evidence is limited that long-term human exposure to organophosphate (OP) pesticides, without poisoning, is associated with adverse peripheral nervous system (PNS) function.
  37. ncbi Lyme disease and the peripheral nervous system
    John J Halperin
    Department of Neurology, North Shore University Hospital, 300 Community Drive, Manhasset, New York 11030, USA
    Muscle Nerve 28:133-43. 2003
    ..The mechanism underlying these neuropathies remains unclear, although interactions between anti-Borrelia antibodies and several peripheral nerve constituent molecules raise intriguing possibilities...
  38. ncbi Autoimmune disorders affecting both the central and peripheral nervous system
    Christoph Kamm
    Department of Neurology, University of Rostock, Germany
    Autoimmun Rev 11:196-202. 2012
    Various case series of patients with autoimmune demyelinating disease affecting both the central and peripheral nervous system (CNS and PNS), either sequentially or simultaneously, have been reported for decades, but their frequency is ..
  39. ncbi Magnetic resonance imaging of the peripheral nervous system
    Guido Stoll
    Department of Neurology, University of Wurzburg, 97080 Wurzburg, Germany
    J Neurol 256:1043-51. 2009
    ..This clinical review provides practical guidelines on the performance of nerve imaging by MRI and will focus on focal lesions exemplified by case presentations...
  40. pmc Mutations affecting the development of the peripheral nervous system in Drosophila: a molecular screen for novel proteins
    S N Prokopenko
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Genetics 156:1691-715. 2000
    In our quest for novel genes required for the development of the embryonic peripheral nervous system (PNS), we have performed three genetic screens using MAb 22C10 as a marker of terminally differentiated neurons...
  41. ncbi Tubulin: a target for antineoplastic drugs into the cancer cells but also in the peripheral nervous system
    Annalisa Canta
    Department of Neuroscience, University of Milan Bicocca, Via Cadore 48 20052 Monza MI, Italy
    Curr Med Chem 16:1315-24. 2009
    ..Besides their antineoplastic efficacy, all the antitubulin drugs share a common toxicity on the peripheral nervous system and peripheral neurotoxicity is a major, potentially dose-limiting side effect also of the epothilones...
  42. pmc Glycoprotein D-independent spread of pseudorabies virus infection in cultured peripheral nervous system neurons in a compartmented system
    T H Ch'ng
    Schultz Laboratory, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    J Virol 81:10742-57. 2007
    ..Neither of the host cell gD receptors (HVEM and nectin-1) is required in target primary fibroblasts for neuron-to-cell spread of HSV-1 or PRV infection...
  43. pmc PTEN and NF1 inactivation in Schwann cells produces a severe phenotype in the peripheral nervous system that promotes the development and malignant progression of peripheral nerve sheath tumors
    Vincent W Keng
    Masonic Cancer Center, Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Cancer Res 72:3405-13. 2012
    ..Together, our findings establish a novel mouse model that can rapidly recapitulate the onset of human neurofibroma tumorigenesis and the progression to MPNSTs...
  44. pmc A monoclonal antibody to O-acetyl-GD2 ganglioside and not to GD2 shows potent anti-tumor activity without peripheral nervous system cross-reactivity
    Nidia Alvarez-Rueda
    Centre de recherche en cancérologie de Nantes Angers, INSERM, Universite de Nantes, Nantes Atlantique Universites, U892, France
    PLoS ONE 6:e25220. 2011
    ..Hence, we investigated the distribution of OAcGD2 in human tissues using mAb 8B6 to study the cross-reactivity of mAb 8B6 with human tissues...
  45. ncbi Evaluation of neuroactive steroid levels by liquid chromatography-tandem mass spectrometry in central and peripheral nervous system: effect of diabetes
    Donatella Caruso
    Department of Pharmacological Sciences, University of Milan, Milano, Italy
    Neurochem Int 52:560-8. 2008
    ....
  46. ncbi Stem-cell plasticity and therapy for injuries of the peripheral nervous system
    Mel Tohill
    Department of Surgery, Royal Free and University College Medical School, University College London, Hampstead, London NW3 2PF, UK
    Biotechnol Appl Biochem 40:17-24. 2004
    ..The peripheral nervous system has an inherent capacity for regeneration, but this is limited and not matched by the level of ..
  47. ncbi Role of the central and peripheral nervous system in the ovarian function
    Luis I Aguado
    Laboratorio de Biología de la Reproducción LABIR, Facultad de Quimica, Facultad de Quimica y Farmacia, Universidad Nacional de San Luis, San Luis, Argentina 5700
    Microsc Res Tech 59:462-73. 2002
    ..However, the relationship of some levels of the nervous system and the ovary offer a wide avenue for future research...
  48. pmc Integrin-linked kinase is required for radial sorting of axons and Schwann cell remyelination in the peripheral nervous system
    Jorge A Pereira
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland
    J Cell Biol 185:147-61. 2009
    ..we report essential functions for ILK in radial sorting of axon bundles and in remyelination in the peripheral nervous system. Our in vivo and in vitro experiments show that ILK negatively regulates Rho/Rho kinase signaling to ..
  49. ncbi Involvement of the peripheral nervous system in synucleinopathies, tauopathies and other neurodegenerative proteinopathies of the brain
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Acta Neuropathol 120:1-12. 2010
    Involvement of the peripheral nervous system (PNS) is relatively common in some neurodegenerative proteinopathies of the brain and may be pathogenetically and diagnostically important...
  50. ncbi Expression pattern of a Krox-20/Cre knock-in allele in the developing hindbrain, bones, and peripheral nervous system
    O Voiculescu
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Genesis 26:123-6. 2000
  51. ncbi The heat shock response modulates transthyretin deposition in the peripheral and autonomic nervous systems
    Sofia Duque Santos
    Molecular Neurobiology Unit, Institute for Molecular and Cell Biology IBMC, 4150 180 Porto, Portugal
    Neurobiol Aging 31:280-9. 2010
    Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease that selectively affects the peripheral nervous system. The putative cause of this life threatening pathology is tissue deposition of mutant transthyretin (TTR), ..
  52. ncbi Bace1 modulates myelination in the central and peripheral nervous system
    Xiangyou Hu
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA
    Nat Neurosci 9:1520-5. 2006
    ..Based upon these and previous studies, we postulate that neuronally enriched Bace1 cleaves neuregulin-1 and that processed neuregulin-1 regulates myelination by means of phosphorylation of Akt in myelin-forming cells...
  53. ncbi Myelin synthesis in the peripheral nervous system
    B Garbay
    Laboratoire de Biogenese Membranaire, CNRS UMR 5544, Universite Victor Segalen, Bordeaux 2, 146, rue Leo Saignat, Case 92, 33076, Bordeaux Cedex, France
    Prog Neurobiol 61:267-304. 2000
    ..b>Peripheral nervous system (PNS) myelin is formed by the differentiation of the plasma membrane of Schwann cells...
  54. ncbi Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system
    M Bortfeld
    Division of Tumor Biochemistry, German Cancer Research Center, University of Heidelberg, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Neuroscience 137:1247-57. 2006
    Dehydroepiandrosterone 3-sulfate and other neurosteroids are synthesized in the CNS and peripheral nervous system where they may modulate neuronal excitability by interacting with ligand-gated ion channels...
  55. ncbi Molecular architecture of smell and taste in Drosophila
    Leslie B Vosshall
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, NY 10021 6399, USA
    Annu Rev Neurosci 30:505-33. 2007
    ..Here we provide a critical review of the recent literature in this field and comment on likely future directions...
  56. ncbi The Drosophila sanpodo gene controls sibling cell fate and encodes a tropomodulin homolog, an actin/tropomyosin-associated protein
    C A Dye
    Department of Cell Biology, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA
    Development 125:1845-56. 1998
    ..Mutations in sanpodo cause many different neuronal peripheral nervous system precursor cells to generate two identical daughter neurons, instead of a neuron and sibling cell...
  57. pmc Expression and distribution of 'high affinity' glutamate transporters GLT1, GLAST, EAAC1 and of GCPII in the rat peripheral nervous system
    Valentina Alda Carozzi
    Department of Neurosciences and Biomedical Technologies, University of Milano Bicocca, Monza MI, Italy
    J Anat 213:539-46. 2008
    ..expression and distribution of glutamate transporters GLT1, GLAST, EAAC1 and of the enzyme GCPII in the peripheral nervous system of female Wistar rats...
  58. ncbi Krox-20 controls myelination in the peripheral nervous system
    P Topilko
    Unité 368 de l Institut National de la Santé et de la Recherche Médicale, Ecole Normale Superieure, Paris, France
    Nature 371:796-9. 1994
    ..blocks Schwann cells at an early stage in their differentiation, thus preventing myelination in the peripheral nervous system. In Krox-20-/- mice, Schwann cells wrap their cytoplasmic processes only one and a half turns around the ..
  59. pmc Essential and distinct roles for cdc42 and rac1 in the regulation of Schwann cell biology during peripheral nervous system development
    Yves Benninger
    Institute of Cell Biology, Department of Biology, Eidgenossische Technische Hochschule Zurich, CH 8093 Zurich, Switzerland
    J Cell Biol 177:1051-61. 2007
    During peripheral nervous system (PNS) myelination, Schwann cells must interpret extracellular cues to sense their environment and regulate their intrinsic developmental program accordingly...
  60. ncbi GABA receptor-mediated effects in the peripheral nervous system: A cross-interaction with neuroactive steroids
    Valerio Magnaghi
    Department of Endocrinology and Center of Excellence on Neurodegenerative Diseases, University of Milan, 20133 Milan, Italy
    J Mol Neurosci 28:89-102. 2006
    ..Herein, we have demonstrated first that in the peripheral nervous system (PNS), the sciatic nerve and myelin-producing Schwann cells express both GABAA and GABAB receptors...
  61. ncbi Differential localization of neuregulin-1 type III in the central and peripheral nervous system
    Dan J Bare
    Department of Anatomy and Cell Biology, University of Illinois Chicago, Chicago, IL 60612 7308, USA
    Brain Res 1369:10-20. 2011
    ..The immunolocalization of NRG1 (III) suggests that it plays a novel role in the myelination fate of CNS axons possibly through undetermined roles in neuronal maturation, or dendritic development and activation...
  62. ncbi Dendrite self-avoidance is controlled by Dscam
    Benjamin J Matthews
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Cell 129:593-604. 2007
    ..The selectivity of Dscam-mediated cell interactions is likely to be widely important in the developing fly nervous system, where processes of cells must distinguish between self and nonself during the construction of neural circuits...
  63. ncbi Gene therapy for the peripheral nervous system: a strategy to repair the injured nerve?
    Matthew R J Mason
    Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam, The Netherlands
    Curr Gene Ther 11:75-89. 2011
    ..lentivirus and adeno-associated virus have been developed to deliver genes to the neurons of the peripheral nervous system, i.e. primary sensory neurons in the dorsal root ganglia and primary motor neurons...
  64. ncbi Formation and effects of neuroactive steroids in the central and peripheral nervous system
    R C Melcangi
    Department of Endocrinology, University of Milan, 20133, Milan, Italy
    Int Rev Neurobiol 46:145-76. 2001
    ..g., aging, peripheral injury)...
  65. ncbi Actions of progesterone and its 5alpha-reduced metabolites on the major proteins of the myelin of the peripheral nervous system
    Luciano Martini
    Department of Endocrinology, Center of Excellence on Neurodegenerative Diseases, University of Milan, via G Balzaretti 9, 20133 Milan, Italy
    Steroids 68:825-9. 2003
    ..and its derivatives might play a role in the control of the synthesis of the two major proteins of the peripheral nervous system (PNS): the glycoprotein Po (Po) and peripheral myelin protein 22 (PMP22)...
  66. pmc Predetermined embryonic glial cells form the distinct glial sheaths of the Drosophila peripheral nervous system
    Christian M von Hilchen
    Institute of Genetics, University of Mainz, Saarstraße 21, Mainz, Germany
    Development 140:3657-68. 2013
    ..This characterisation of the embryonic origin and development of each glial sheath will facilitate functional studies, as they can now be addressed distinctively and genetically manipulated in the embryo. ..
  67. ncbi Roles of the amyloid precursor protein family in the peripheral nervous system
    John H Caldwell
    Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO 80045, USA
    Mech Dev 130:433-46. 2013
    ..The results summarized here from invertebrate and vertebrate systems confirm that the NMJ with its accessibility, large size, and homogeneity provides a model synapse for identifying and analyzing molecular pathways of APP actions...
  68. ncbi S-100 proteins in the human peripheral nervous system
    T Gonzalez-Martinez
    Departamento de Morfologia y Biologia Celular, Universidad de 33006 Oviedo, Spain
    Microsc Res Tech 60:633-8. 2003
    This article reviews the distribution of S100 proteins in the human peripheral nervous system. The expression of S100 by peripheral glial cells seems to be a distinctive fact of these cells, independently of their localization and their ..
  69. ncbi Neuropathological changes in the peripheral nervous system and spinal cord in a transgenic mouse model of Niemann-Pick disease type A
    P Marmiroli
    Department of Neurosciences and Biomedical Technologies, University of Milan Bicocca, Monza, Italy
    Clin Neuropathol 28:263-74. 2009
    ..in the central nervous system of ASM deficient transgenic (ASMKO) mice, while a detailed study on the peripheral nervous system (PNS) at different ages is currently lacking...
  70. ncbi Effect on the peripheral nervous system of systemically administered dimethylsulfoxide in the rat: a neurophysiological and pathological study
    G Cavaletti
    Clinica Neurologica, Universita di Milano Bicocca, Ospedale S Gerardo, v Donizetti 106, 20052 Monza, Italy
    Toxicol Lett 118:103-7. 2000
    ..8-7. 2%) on the peripheral nervous system of Wistar rats treated for 10 consecutive days and followed-up for an additional 45 days...
  71. ncbi Phase I study of carboplatin, doxorubicin and weekly paclitaxel in patients with advanced ovarian carcinoma
    V Hess
    Royal Marsden Hospital, London, UK
    Ann Oncol 14:638-42. 2003
    ..Toxicity can be reduced by weekly administration. We examined the tolerability of weekly paclitaxel in combination with carboplatin and doxorubicin...
  72. ncbi Mu-opioid receptor mRNA regulation during morphine tolerance in the rat peripheral nervous system
    Thomas Meuser
    Department of Anesthesiology, University of Cologne, Cologne, Germany
    Anesth Analg 97:1458-63. 2003
    In vivo data on opioid receptor mRNA regulation after agonist exposure in the peripheral nervous system are lacking...
  73. ncbi Induction of neuropilins-1 and -2 and their ligands, Sema3A, Sema3F, and VEGF, during Wallerian degeneration in the peripheral nervous system
    Marina Scarlato
    Division of Neurology, Children s Hospital of Philadelphia, and Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA
    Exp Neurol 183:489-98. 2003
    ..known to play prominent roles in axonal pathfinding, fasciculation, and blood vessel formation during peripheral nervous system (PNS) development. We confirmed a prior report (Exp. Neurol...
  74. pmc Boundary cap cells are peripheral nervous system stem cells that can be redirected into central nervous system lineages
    Violetta Zujovic
    Centre de Recherche de l Institut du Cerveau et de Moelle épinière, Universite Pierre et Marie Curie Paris 6, Unité Mixte de Recherche S975, 75013 Paris, France
    Proc Natl Acad Sci U S A 108:10714-9. 2011
    ..factor Krox20, participate in the formation of the boundary between the central nervous system and the peripheral nervous system. To study BC stemness, we developed a method to purify and amplify BC in vitro from Krox20(Cre/+), R26R(..
  75. pmc ApoE isoform-specific regulation of regeneration in the peripheral nervous system
    Laura H Comley
    Euan MacDonald Centre for Motor Neurone Disease Research, University of Edinburgh, Edinburgh EH8 9XD, UK
    Hum Mol Genet 20:2406-21. 2011
    ..The extent to which different apoE isoforms influence degenerative and regenerative events in the peripheral nervous system (PNS) is still to be established, and the mechanisms through which apoE exerts its isoform-specific ..
  76. ncbi Transcuticular optical imaging of stimulus-evoked neural activities in the Drosophila peripheral nervous system
    Azusa Kamikouchi
    School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
    Nat Protoc 5:1229-35. 2010
    ..Interfering with this exoskeleton is critical in the case of the peripheral nervous system (PNS), as sensory neurons are often located directly beneath the cuticle and are associated with ..
  77. ncbi Chronic idiopathic axonal polyneuropathy and successful aging of the peripheral nervous system in elderly people
    Alexander F J E Vrancken
    Department of Neurology, C03 236, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Arch Neurol 59:533-40. 2002
    ..Chronic idiopathic axonal polyneuropathy (CIAP) is a frequent neurologic disorder in elderly persons. In view of the aging population, it is important to know the long-term prognosis of CIAP...
  78. pmc Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates
    William J Buchser
    Miami Project to Cure Paralysis, Department of Pharmacology, University of Miami, Miller School of Medicine, Miami, Florida, United States of America
    PLoS ONE 7:e38101. 2012
    ..b>Peripheral nervous system (PNS) neurons exhibit increased regenerative ability compared to central nervous system neurons, even in ..
  79. ncbi Effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide
    Helge Kjuus
    Department of Occupational Medicine, National Institute of Occupational Health, Oslo, Norway
    Scand J Work Environ Health 30:21-9. 2004
    This study evaluates the possible toxic effects on the peripheral nervous system of tunnel workers exposed to acrylamide and N-methylolacrylamide during grouting work.
  80. ncbi Distribution of inducible nitric oxide synthase and tumor necrosis factor-alpha in the peripheral nervous system of Lewis rats during ascending paresis and spontaneous recovery from experimental autoimmune neuritis
    Cristiane L R de la Hoz
    Department of Anatomy, Cellular Biology and Physiology, State University of Campinas, 13083 970 Campinas, Brazil
    Neuroimmunomodulation 17:56-66. 2010
    ..Inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-alpha) are pleiotropic molecules with widespread action in autoimmune diseases...
  81. ncbi hamlet, a binary genetic switch between single- and multiple- dendrite neuron morphology
    Adrian W Moore
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143, USA
    Science 297:1355-8. 2002
    ..In the Drosophila peripheral nervous system (PNS), the external sensory (ES) neurons have a single nonbranched dendrite, whereas the lineally ..
  82. ncbi NG2 and Olig2 expression provides evidence for phenotypic deregulation of cultured central nervous system and peripheral nervous system neural precursor cells
    Cecile Dromard
    INSERM U583, Physiopathologie et Thérapie des Déficits Sensoriels et Moteurs Institut des Neurosciences de Montpellier, Hopital St Eloi, BP 74103 80, avenue Augustin Fliche 34091 Montpellier Cedex 05, France
    Stem Cells 25:340-53. 2007
    ..Olig2 expression was also induced in astrocytes and embryonic peripheral nervous system (PNS) cells in culture after EGF/FGF treatment...
  83. ncbi Use of genetically engineered transgenic mice to investigate the role of galanin in the peripheral nervous system after injury
    F E Holmes
    LINE, DHB, University of Bristol, Whitson Street, Bristol BS1 3NY, UK
    Neuropeptides 39:191-9. 2005
    ..This pattern of expression suggests that it may play a role in the adaptive response of the peripheral nervous system (PNS) to injury...
  84. ncbi Association of the ecto-ATPase NTPDase2 with glial cells of the peripheral nervous system
    Norbert Braun
    Biozentrum der J W Goethe Universitaet, AK Neurochemie, Zoologisches Institut, Marie Curie Strasse 9, D 60439 Frankfurt am Main, Germany
    Glia 45:124-32. 2004
    Cellular signaling via extracellular nucleotides appears to play a major role in the functioning of the peripheral nervous system. Information regarding the functional characterization of nucleotide P2 receptors or their expression ..
  85. ncbi Fast optical signals in the peripheral nervous system
    Yunjie Tong
    Tufts University, Department of Biomedical Engineering, Medford, Massachusetts 02155, USA
    J Biomed Opt 11:044014. 2006
    ..Our findings support the hypothesis that the peripheral nervous system undergoes neurovascular coupling, even though more data is needed to prove such hypothesis.
  86. ncbi Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury
    Natsuki Nakayama
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    Neurosci Res 58:176-82. 2007
    ..In mice treated with withanoside IV (10micromol/kg body weight/day, for 21 days), axonal density and peripheral nervous system (PNS) myelin level increased...
  87. ncbi The peripheral nervous system and the perception of verticality
    G Mazibrada
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London, UK
    Gait Posture 27:202-8. 2008
    ..In the two patients with spinal injury, bias towards the side of a preceding tilt was not significant. These findings confirm the importance of somatosensory input from the trunk to the perception of SPV in the seated position...
  88. pmc Calretinin in the peripheral nervous system of the adult zebrafish
    M B Levanti
    Dipartmento di Morfologia, Biochimica, Fisiologia e Produzione Animale, Sezione di Morfologia, Facolta di Medicina Veterinaria, Universita di Messina, Italy
    J Anat 212:67-71. 2008
    ..in the central nervous system and chemosensory cells of the teleosts, but its presence in the peripheral nervous system of fishes is unknown...
  89. pmc Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study
    Angelo Di Iorio
    Laboratory of Clinical Epidemiology, Department of Medicine and Sciences of Aging, University G D Annunzio, Via dei Vestini 5, 66013 Chieti Scalo, Italy
    Neurobiol Aging 27:1280-8. 2006
    Aging of the peripheral nervous system is associated with several morphologic and functional changes, including a decrease of the nerve conduction velocity...
  90. ncbi Conditional beta1-integrin gene deletion in neural crest cells causes severe developmental alterations of the peripheral nervous system
    Thomas Pietri
    UMR144, CNRS, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Development 131:3871-83. 2004
    ..Thus, beta1-integrins are important for the control of embryonic and postnatal peripheral nervous system development.
  91. ncbi Alterations in gene expression associated with primary demyelination and remyelination in the peripheral nervous system
    A D Toews
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill 27599, USA
    Neurochem Res 22:1271-80. 1997
    ....
  92. ncbi Anatomy of the peripheral nervous system
    B Goldstein
    Spinal Cord Injury and Disorders Strategic Healthcare Group, Department of Veterans Affairs, Puget Sound Health Care System, Seattle, Washington, USA
    Phys Med Rehabil Clin N Am 12:207-36. 2001
    This article is an overview of the structure and components of the peripheral nervous system. The fine structure and gross anatomy of peripheral nerves and ganglia are described...
  93. ncbi Local and target-derived actions of neurotrophins during peripheral nervous system development
    P Ernfors
    Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Cell Mol Life Sci 58:1036-44. 2001
    ....
  94. ncbi P2X receptors and their roles in astroglia in the central and peripheral nervous system
    Peter Illes
    Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Germany
    Neuroscientist 18:422-38. 2012
    Astrocytes are a class of neural cells that control homeostasis at all levels of the central and peripheral nervous system. There is a bidirectional neuron-glia interaction via a number of extracellular signaling molecules, glutamate and ..
  95. pmc Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system
    Katharina Zimmermann
    Department of Cardiology, Manton Center for Orphan Disease, and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:18114-9. 2011
    ..Cold sensing in the innocuous range of cold (>10-15 °C) in the mammalian peripheral nervous system is thought to rely primarily on transient receptor potential (TRP) ion channels, most notably the ..
  96. pmc The organizational hypothesis and final common pathways: Sexual differentiation of the spinal cord and peripheral nervous system
    Nancy G Forger
    Department of Psychology and Center for Neuroendocrine Studies, University of Massachusetts, Amherst MA 01003, USA
    Horm Behav 55:605-10. 2009
    ..organizational hypothesis," this paper reviews work on sexual differentiation of the spinal cord and peripheral nervous system. Topics considered include the spinal nucleus of the bulbocavernosus, the ejaculation center, the ..
  97. ncbi Upregulation of erythropoietin in rat peripheral nervous system with experimental autoimmune neuritis
    Meejung Ahn
    Department of Veterinary Anatomy, College of Veterinary Medicine, Veterinary Medical Research Institute, Jeju National University, Jeju 690 756, South Korea
    Brain Res 1333:82-90. 2010
    ..However, peripheral nervous system (PNS) EPO and EPO receptor expression has not been widely studied...
  98. pmc Peripherin is a subunit of peripheral nerve neurofilaments: implications for differential vulnerability of CNS and peripheral nervous system axons
    Aidong Yuan
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 32:8501-8. 2012
    ..Our findings provide a basis for its close relationship with neurofilaments in PNS diseases associated with neurofilament accumulation...
  99. ncbi Thiopalmitoylated peptides from the peripheral nervous system myelin p0 protein: synthesis, characterization, and neuritogenic properties
    Wissam Beaino
    laboratoire d imagerie et de neurosciences cognitives LINC, Universite de Strasbourg CNRS, Strasbourg Cedex, France
    Bioconjug Chem 21:1439-47. 2010
    ..studied the effect of thiopalmitoylation on the immunogenic and neuritogenic properties of P0, the major peripheral nervous system (PNS) myelin protein, which is thiopalmitoylated at cysteine 153, and described as a candidate ..
  100. pmc Transcriptional profiling of intrinsic PNS factors in the postnatal mouse
    Robin P Smith
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, 1400 NW 12th Ave, Miami, FL 33136, USA
    Mol Cell Neurosci 46:32-44. 2011
    Neurons in the peripheral nervous system (PNS) display a higher capacity to regenerate after injury than those in the central nervous system, suggesting cell specific transcriptional modules underlying axon growth and inhibition...
  101. ncbi Hedgehog signaling regulates myelination in the peripheral nervous system through primary cilia
    Kentaro Yoshimura
    Department of Anatomy and Cell Biology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimo Kateau, Chuo, Yamanashi 409 3898, Japan
    Differentiation 83:S78-85. 2012
    ..In the peripheral nervous system (PNS), Schwann cells (SCs) engage in myelination...

Research Grants71

  1. The Neuroimmunology of Viral Infection
    DANIEL J CARR; Fiscal Year: 2013
    ..the brain stem with an intact type I IFN system are critical to control viral infection whereas in the peripheral nervous system (i.e...
  2. Genetics of the Neuromuscular Junction: Mechanisms and Disease Models
    Robert W Burgess; Fiscal Year: 2013
    ..is to understand how dominant mutations in tRNA synthetase genes cause axonal degeneration in the peripheral nervous system. Mutations in glycyl tRNA synthetase (GARS) and tyrosyl tRNA synthetase (YARS) cause Charcot-Marie-Tooth ..
  3. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..NHE-1 over expression;and 3) assess the contribution of NHE-1 to oxidative-nitrosative stress in peripheral nervous system of diabetic rats and high glucose-exposed cultured HSC and co-cultured rat SC and DRG neurons...
  4. Roles of RhoA/Rho-kinase Signaling in Cavernous Neurons Following Axonal Injury
    TRINITY JUDE BIVALACQUA; Fiscal Year: 2013
    ..My career development award training goals include: 1. Understanding the molecular basis of peripheral nervous system function including neural development, synaptic transmission, and neuropathology;2...
  5. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..between glial cells and neuronal axons as well as dendrites in different parts of the central and peripheral nervous system. We recently discovered a new form of neuron-glia communication that involves the ephrin-A3 ligand ..
  6. Microfluidic-microtiter interface for rapid large-scale screenings of C. elegans
    Adela Ben Yakar; Fiscal Year: 2010
    ..the axons of the central nervous system where the regeneration process is poor or absent, axons of the peripheral nervous system are able to regenerate, though inefficiently...
  7. HIV/NeuroAIDS Patient Derived Induced Pluripotent Stem (iPS) Cells
    Rodney J Nash; Fiscal Year: 2012
    ..a myriad of novel neurologic disorders which are a primary consequence of damage to the central and peripheral nervous system by HIV...
  8. Gene Networks in Neural Crest-derived Innervation of the Lower Urinary Tract
    E MICHELLE MICHELLE SOUTHARD SMITH; Fiscal Year: 2010
    ..It is possible that signaling molecules essential to development of other aspects of the peripheral nervous system may also play a role in development of innervation in the LUT...
  9. Mechanisms of Neural Crest Differentiation during Craniofacial Development
    Vivian M Lee; Fiscal Year: 2010
    ..extensively and form diverse derivatives throughout the embryo, including melanocytes, most of the peripheral nervous system (neurons and glia), as well as most of the skull and face, including cartilage, bone, and smooth muscle...
  10. Inflammasome Activation in Complex Regional Pain Syndrome
    Wade S Kingery; Fiscal Year: 2013
    ..3. We will test the hypothesis that intact peripheral nervous system signaling is required for the activation of inflammasomes in skin after fracture, and that this ..
  11. Genetic Susceptibility Factors in the Etiology of Neuroblastoma
    Andrew Olshan; Fiscal Year: 2012
    DESCRIPTION: Neuroblastoma (NB) is a tumor of the peripheral nervous system. It is a neural crest cell derivative, originating from the sympathoadreanal lineage, and its development is related to that of normal sympathetic neurons...
  12. PROTEINASE-ACTIVATED RECEPTORS/PERIPHERAL NERVOUS SYSTEM
    Nigel W Bunnett; Fiscal Year: 2010
    ....
  13. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    b>Peripheral nervous system (PNS) disorders have become the foremost neurological complications among patients with HIV infection in the industrialized world...
  14. STRUCTURAL STUDIES ON PROKARYOTIC POTASSIUM CHANNELS
    Adrian Gross; Fiscal Year: 2013
    ..are used to coordinate the beating of the heart and underlie the complex function of the central and peripheral nervous system. When ion channels malfunction, serious maladies ensue, such as heart arrhythmias, epilepsy, and even ..
  15. Role of axoglial CAMs in the organization of myelinated axons
    Elior Peles; Fiscal Year: 2013
    ..In the peripheral nervous system (PNS), myelinating Schwann cells regulate this precise organization of the axonal membrane through ..
  16. Using Electrochemical Methods to Probe Neuronal Signaling in the GI Tract
    Greg M Swain; Fiscal Year: 2010
    ..The extension of these techniques to the study of the peripheral nervous system constitutes an interesting and significant development...
  17. A zebrafish model for neural regeneration
    ALLISON F ROSENBERG; Fiscal Year: 2012
    ..degeneration is highlighted by how its speed and efficiency determine the success of regeneration in the Peripheral Nervous system, whereas its slowness and inefficacy prevent regeneration in the Central Nervous system...
  18. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..First identified and cloned in primary sensory afferent neurons in the peripheral nervous system, mounting evidence supports the expression and activity of these channels in brain...
  19. How does misregulation of PI3,5P2 signaling lead to neurodegeneration?
    Lois S Weisman; Fiscal Year: 2013
    ..Unexpectedly, the main defect is massive neurodegeneration. Affected neurons in both the brain and the peripheral nervous system develop large vacuoles that arise from endosomes...
  20. Role of ERK1/2 in Neuromuscular Synapses and Myofiber Development in vivo
    Mendell Rimer; Fiscal Year: 2013
    ..A strategy of conditional gene targeting that has recently bear fruit in other cells of the peripheral nervous system will be used to selectively inactivate Erk1/2 in skeletal muscle fibers...
  21. MOLECULAR AND GENETIC ANALYSIS OF GPR126 IN PERIPHERAL NERVE.
    Kelly R Monk; Fiscal Year: 2013
    ..In the peripheral nervous system, specialized cells called Schwann cells spiral themselves around axons to form the myelin sheath...
  22. STEM CELLS IN PERIPHERAL NERVOUS SYSTEM DEVELOPMENT
    Sean J Morrison; Fiscal Year: 2013
    ..These cells migrate throughout the embryo and give rise to the peripheral nervous system (PNS) including sensory, sympathetic, parasympathetic, and enteric ganglia, as well as peripheral nerves...
  23. Quantitative Analysis of RET Receptor Activation and Signaling
    Adrian Whitty; Fiscal Year: 2013
    ..kinase that is important in sustaining the survival of a key population of sensory neurons in the peripheral nervous system, as a model system for the development and application of methods for the quantitative study of GF ..
  24. ATYPICAL ODONTALGIA AND ENDODONTIC TREATMENT, SENSORY TESTING AND GENETIC STUDY
    Eli Eliav; Fiscal Year: 2010
    ..AO development following root canal treatment and to indicate if the pain mechanism is limited to the peripheral nervous system, or if it is being maintained by the central nervous system (central sensitization)...
  25. RECOVERY OF FUNCTION FOLLOWING NEURAL DAMAGE
    Richard E Zigmond; Fiscal Year: 2010
    ..promoting nerve regeneration and how these agents might be used to enhance clinical recovery both in the peripheral nervous system and, hopefully, in the CNS...
  26. STUDIES OF P2X ATP RECEPTORS
    RICHARD HUME; Fiscal Year: 2009
    ..P2X receptors are expressed in virtually every tissue, including neurons and glia of the central and peripheral nervous system, smooth, skeletal and cardiac muscle, cochlear hair cells, platelets, most classes of white blood cells, ..
  27. STUDIES USING PURIFIED ACETYLCHOLINE RECEPTORS
    JON MARTIN LINDSTROM; Fiscal Year: 2012
    ..These receptors are found in the brain, peripheral nervous system and many non-neuronal tissues...
  28. Structural Mechanism of the Acetylcholine Receptor in Tubular Membrane Crystals
    PETER NIGEL UNWIN; Fiscal Year: 2013
    ..is the best understood member of a family of synaptic ion channels which function in the central and peripheral nervous system, and are pharmaceutical targets for numerous human diseases and psychiatric disorders, including ..
  29. NFkB Targets and Neural Crest Development
    MICHAEL WILLIAM KLYMKOWSKY; Fiscal Year: 2010
    ..layer;the neural crest gives rise to migrating cells that differentiate into cartilage, melanocytes, the peripheral nervous system, and the outflow tract of the heart...
  30. Phenotyping pain in a mouse model of pancreatic cancer
    Brian M Davis; Fiscal Year: 2012
    ..Together these findings suggest an intimate relationship between the peripheral nervous system and pancreatic cancer, wherein tumor-produced growth factors induce nerve sprouting and hypertrophy, ..
  31. Generation of monoclonal and polyclonal antibodies to neolacto-series ganglioside
    Amjad A Ilyas; Fiscal Year: 2010
    ..While ganglio- series gangliosides are present in both the central nervous system (CNS) and peripheral nervous system (PNS), the neolacto-series gangliosides are present mainly in the PNS...
  32. Proteolysis of cadherins in cranial neural crest
    ANDREW THOMAS SCHIFFMACHER; Fiscal Year: 2013
    ..migrate throughout the whole embryo and then differentiate into a diverse range of cell types including peripheral nervous system ganglia and neurons, cartilage, connective tissue and bone...
  33. A Novel CNS-Penetrable Antiretroviral
    Ned C Sacktor; Fiscal Year: 2011
    ..Unfortunately, the HIV-associated prevalence of both central nervous system (CNS) and peripheral nervous system (PNS) disorders is on the rise, suggesting a failure of antiretroviral therapies to protect neurological ..
  34. KINASES IN ION COTRANSPORTER FUNCTION
    Eric J Delpire; Fiscal Year: 2013
    ..in the kidney, control of blood pressure, and modulation of inhibitory synaptic transmission in the peripheral nervous system. SPAK, OSR1, WNK kinases, and possibly some PKC isotypes are all involved in modulating cation-chloride ..
  35. The Role of Perineurial Glia in PNS Regeneration
    GWENDOLYN LEWIS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The peripheral nervous system (PNS) serves the essential function of relaying information between the central nervous system (CNS) and the body...
  36. Extrinsic signaling in neural crest and craniofacial development
    KIMBERLY ELAINE INMAN; Fiscal Year: 2010
    ..neural crest gives rise to cartilage, bone, and connective tissue in the head, neurons and glia of the peripheral nervous system and portions of the heart outflow tract...
  37. Protection against acute inflammatory demyelinating peripheral nerve disease
    EVAN STUBBS; Fiscal Year: 2009
    ..European form of Guillain-Barre'Syndrome (GBS), a disabling inflammatory autoimmune disease of the peripheral nervous system that is characterized by rapid-onset symmetrical paresis with areflexia progressing to neuromuscular ..
  38. A role for the methyltransferase NSD3 in neural crest specification and migration
    Bridget T Jacques-Fricke; Fiscal Year: 2013
    ..in vertebrate embryos to form the majority of the craniofacial skeleton, outflow tract of the heart, and peripheral nervous system. Common birth defects such as cleft lip and palate result from abnormalities in neural crest cell ..
  39. Novel SIV Model of HAND
    Joseph L Mankowski; Fiscal Year: 2013
    ..These advantages demonstrate the model's ability to study latent viral reservoirs in brain and the peripheral nervous system. Virus replication in brain is detectable at low levels using a sensitive single copy assay;SIV DNA ..
  40. CHEMOKINE RECEPTOR FUNCTION IN THE NERVOUS SYSTEM
    Richard J Miller; Fiscal Year: 2013
    ..in the nervous system such as the dentate gyrus (central nervous system) or dorsal root ganglia (peripheral nervous system) failed to develop properly...
  41. Mechanisms of Caspr2 antibodies
    Eric Lancaster; Fiscal Year: 2013
    ..Aim 2 will explore the effects of Caspr2 antibodies on central and peripheral nervous system axons. And Aim 3 will examine the factors protecting nerve axons from auto- antibodies...
  42. Roles for Serotonin in Autonomic Innervation of the Lower Urinary Tract
    KAREN ELAINE RITTER; Fiscal Year: 2013
    ..in these areas, there have been very few studies inspecting the role of 5-HT in development of other peripheral nervous system components...
  43. MOLECULAR GENETICS OF LYME ARTHRITIS SUSCEPTIBILITY
    Janis J Weis; Fiscal Year: 2013
    ..and in humans is responsible for a number of symptoms involving the heart, joints, central and peripheral nervous system, and skin...
  44. Netrin5 in Mammalian Neurodevelopment
    Robert W Burgess; Fiscal Year: 2013
    ..how sensory axons identify the dorsal root entry zone, and how the boundary between the central and peripheral nervous system is established. The nature of this boundary is unclear...
  45. Mechanisms of Jedi-mediated engulfment of apoptotic cells
    CHELSEA SUZANNE SULLIVAN; Fiscal Year: 2013
    ..2006). The cells responsible for neuron corpse clearance in the peripheral nervous system (PNS) were recently identified as satellite glial cell precursors (Wu et al., 2009)...
  46. Retasking an FDA-approved Drug for use in Peripheral Nerve Regeneration
    Melitta Schachner; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Despite the peripheral nervous system's (PNS) intrinsic capability to regenerate following injury, permanent dysfunction of the PNS is common...
  47. Monocyte-Macrophage Dynamics in NeuroAIDS
    Jay Rappaport; Fiscal Year: 2013
    ..in part, because of the invasion of macrophages derived from peripheral blood into the central and peripheral nervous system tissues...
  48. Functional Genomics of Axonal and Synapse Regeneration
    Stephen M Strittmatter; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The CNS of adult mammals, as compared to the peripheral nervous system or nervous system of other organisms, has extremely limited capacity for axon regeneration and synapse reformation...
  49. Epigenetic Regulation in Cranial Neural Crest Development
    Na Hu; Fiscal Year: 2012
    ..the body and participates in the formation of many body parts such as face, heart, cartilage, skin and peripheral nervous system. Our long-term goal is to dissect the mechanisms controlling neural crest formation and migration...
  50. Analysis of neuropoietic cytokines and their receptors in diabetic neuropathy
    LISA RENEE BANNER; Fiscal Year: 2012
    ..One of the most common complications is damage to the peripheral nervous system, a condition known as diabetic neuropathy that occurs in more than 60% of diabetics...
  51. Mechanisms Modulating Cytoskeletal Dynamics During Schwann Cell Myelination
    CRISTINA MARIA FERNANDEZ VALLE; Fiscal Year: 2010
    ..Myelinating glial cells such as Schwann cells of the peripheral nervous system undergo stage specific changes in morphology that enable them to elaborate myelin around an axon...
  52. Role of DNA damage in the early steps of HSV infection and latency in neurons
    Matthew D Weitzman; Fiscal Year: 2013
    ..The virus is characterized by its ability to form latent infections in neurons of the peripheral nervous system, from which it can reactivate to cause recurrent disease...
  53. Quantitative MRI of the Human Peripheral Nervous System In Vivo
    RICHARD DARRELL DORTCH; Fiscal Year: 2013
    ..g., diabetic neuropathy) as well as in diseases that affect myelin and/or axons within the central nervous system (e.g., multiple sclerosis). ..
  54. Novel Six1 co-factors and their role in placode development
    KAREN MARY NEILSON; Fiscal Year: 2010
    ..This application is designed to use information from two important animal models to identify new candidates for vertebrate craniofacial and cranial peripheral nervous system genetic defects.
  55. Novel Studies of Bladder Regeneration in a Rodent Model
    George Christ; Fiscal Year: 2009
    ..related to congenital anomalies, cancer, infection, inflammation or lesions of the central or peripheral nervous system. Regardless of etiology, in all cases these conditions eventually result in largely irreparable damage ..
  56. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2013
    ..sense of touch are inherent to many inherited and acquired human disorders that affect the skin and/or peripheral nervous system. These disorders can affect some or all of the touch receptors that are found in the skin...
  57. Gene Function Profiling of Neural Crest Cell Diversification
    Christine E Beattie; Fiscal Year: 2013
    ..cells that is the source of multiple different cell types including neurons and glia of the peripheral nervous system, pigment cells and major elements of the craniofacial skeleton, among others...
  58. LRP-1 is a multifunctional regulator during peripheral nerve injury and pain.
    Wendy M Campana; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Direct injury to the sciatic nerve and other major nerves in the peripheral nervous system (PNS) may cause chronic neuropathic pain...
  59. Alpha-Herpesvirus Transport on Axons
    Gregory Allan Smith; Fiscal Year: 2013
    ..Both viruses establish life-long latent infections in sensory neurons of the peripheral nervous system, and both are established models for use in the laboratory...
  60. Molecular Interactions During Neural Crest Formation
    MARTIN IGNACIO GARCIA-CASTRO; Fiscal Year: 2013
    ..into several derivatives, including: craniofacial components (muscle and cartilage amongst others), peripheral nervous system and melanocytes of the skin...
  61. The role of prdm1 in neural cell fate specification
    Kristin Bruk Artinger; Fiscal Year: 2010
    ..lateral portion of the neural plate and while neural crest cells migrate extensively to form all of the peripheral nervous system (PNS;among other derivatives), Rohon-Beard sensory neurons remain within the central nervous system (CNS)..
  62. Novel Pathways of HAARTmediated Neuronal Toxicity in the Central Nervous System
    Kelly L Jordan Sciutto; Fiscal Year: 2010
    ..Although HAART is neurotoxic in both the peripheral nervous system and cultured neurons, the contribution of HAART to HIV-associated neurocognitive disorders is unknown...
  63. STRUCTURES OF RNA BINDING PROTEINS FROM INFLUENZA VIRUS
    Gaetano Montelione; Fiscal Year: 2000
    ..It is the most abundant and widely distributed neuropeptide present in the mamalian central and peripheral nervous system. NPY has been implicated in a wide variety of central and peripheral functions...
  64. Genetic targeting of CGRP actions in a murine model of migraine
    ERIC ALAN KAISER; Fiscal Year: 2011
    ..Mice that express hRAMPI throughout the central nervous system (CNS) and peripheral nervous system (PNS) exhibit light aversion and mechanical allodynia in response to CGRP administration in the CNS...
  65. HCO3-transporters in Drosophila and Mosquitoes
    MICHAEL ROMERO; Fiscal Year: 2003
    ..NDAE1 to epithelia (gut, Malpighian tubules and salivary glands) as well as the central and peripheral nervous system. We have also identified and cloned a second Drosophila HC03-transporter, CG8177 (Celera notation)...
  66. The Post-Transcriptional Regulation of Peripheral Myelin Protein 22 by MicroRNAs
    JONATHAN VERRIER; Fiscal Year: 2009
    ..is an integral membrane protein that is primarily expressed in myelinforming Schwann cells of the peripheral nervous system. The misexpression of PMP22 is implicated in a host of hereditary demyelinating peripheral neuropathies ..
  67. The role of TRAF6 in the regulation of neurite outgrowth
    ANA LUISA JORDAO PERDIGOTO; Fiscal Year: 2010
    ..The presence of outgrowth inhibitory cues in the central nervous system, but not the peripheral nervous system, contribute to the inability of the central nervous system to regenerate...
  68. Fetal Ethanol Effects on the Peripheral Nervous System
    Mary Johnson; Fiscal Year: 2004
    ..We know far less about fetal ethanol exposure and its effect on the peripheral nervous system (PNS), despite its importance in the maintenance of the body's internal milieu as well as in the ..
  69. Matrix Control of Glial/Axonal Interactions in Developing Nerves
    Bruce Patton; Fiscal Year: 2009
    ..Defects in the mechanisms controlling glial cell growth contribute to oncogenesis in the brain and peripheral nervous system. Conversely, insufficient glial cell numbers are associated with functional deficits in multiple ..
  70. Regenerative Healing Using ECM Based Scaffolds
    Ioannis Yannas; Fiscal Year: 2009
    ..In the proposed study the mechanism of induction of regeneration will be studied in the peripheral nervous system. Recently obtained evidence shows that during healing of the transected rat sciatic nerve, contractile ..
  71. PRE & POSTSYNAPTIC NICOTINIC ACHRS--STRUCTURE & FUNCTION
    Peter Sargent; Fiscal Year: 1999
    ..evidence that nAChRs generally serve the same function in the central nervous system that they do in the peripheral nervous system, where they underlie fast, excitatory synaptic transmission...