pyramidal cells

Summary

Summary: Projection neurons in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.

Top Publications

  1. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
  2. ncbi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
  3. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
  4. pmc The subcellular organization of neocortical excitatory connections
    Leopoldo Petreanu
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Nature 457:1142-5. 2009
  5. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
  6. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
  7. ncbi What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance
    Nicolas Brunel
    Centre National de la Recherche Scientifique Neurophysique et Physiologie du Système Moteur Université Paris René Descartes, 75270 Paris Cedex 06, France
    J Neurophysiol 90:415-30. 2003
  8. ncbi Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
    Matthew E Larkum
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Science 325:756-60. 2009
  9. ncbi Dendritic discrimination of temporal input sequences in cortical neurons
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Science 329:1671-5. 2010
  10. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001

Research Grants

  1. Kainate Receptors on Hippocampal Interneurons
    Matthew Frerking; Fiscal Year: 2007
  2. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
  3. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
  4. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
  5. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
  6. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
  7. STRESS-OPIOID INTERACTION IN HIPPOCAMPUS
    Teresa A Milner; Fiscal Year: 2013
  8. PET and MRI Neuronal Loss and Amyloid and Tau Deposition in Alzheimer Disease
    Laurel Martin-Harris; Fiscal Year: 2012
  9. GABA-A Receptor Pharmacology of Neural Coding in Hippocampal Place Cells
    TARA MONIQUE STEWART; Fiscal Year: 2012
  10. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010

Detail Information

Publications339 found, 100 shown here

  1. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
    ..In particular, distinct GABAergic (gamma-aminobutyric acid-releasing) cell types subdivide the surface of pyramidal cells and act in discrete time windows, either on the same or on different subcellular compartments...
  2. ncbi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
    ..Thus, single dendritic branches can already exhibit nonuniform synaptic integration, with the computational strategy shifting from temporal coding to rate coding along the dendrite...
  3. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  4. pmc The subcellular organization of neocortical excitatory connections
    Leopoldo Petreanu
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Nature 457:1142-5. 2009
    ..Our experiments reveal high specificity in the subcellular organization of excitatory circuits...
  5. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..mouse strain in which the N-methyl-D-asparate (NMDA) receptor gene is ablated specifically in the CA3 pyramidal cells of adult mice...
  6. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
    ..The map of the whole cortical circuit shows that there are very few "strong" but many "weak" excitatory projections, each of which may involve only a few percentage of the total complement of excitatory synapses of a single neuron...
  7. ncbi What determines the frequency of fast network oscillations with irregular neural discharges? I. Synaptic dynamics and excitation-inhibition balance
    Nicolas Brunel
    Centre National de la Recherche Scientifique Neurophysique et Physiologie du Système Moteur Université Paris René Descartes, 75270 Paris Cedex 06, France
    J Neurophysiol 90:415-30. 2003
    ..Faster excitation than inhibition, or a higher excitation/inhibition ratio, favors the feedback loop and a much slower oscillation (typically in the gamma range)...
  8. ncbi Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
    Matthew E Larkum
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Science 325:756-60. 2009
    ....
  9. ncbi Dendritic discrimination of temporal input sequences in cortical neurons
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Science 329:1671-5. 2010
    ..Pyramidal cell dendrites can thus act as processing compartments for the detection of synaptic sequences, thereby implementing a fundamental cortical computation...
  10. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Here, we show that in rat hippocampal pyramidal cells this window is very narrow (less than 2 milliseconds)...
  11. pmc Driving fast-spiking cells induces gamma rhythm and controls sensory responses
    Jessica A Cardin
    McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
    Nature 459:663-7. 2009
    ..Our data directly support the fast-spiking-gamma hypothesis and provide the first causal evidence that distinct network activity states can be induced in vivo by cell-type-specific activation...
  12. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ....
  13. ncbi Synfire chains and cortical songs: temporal modules of cortical activity
    Yuji Ikegaya
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:559-64. 2004
    ..Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing...
  14. pmc Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons
    A Destexhe
    Unite de Neurosciences Integratives et Computationnelles, CNRS, UPR 2191, Gif sur Yvette, France
    Neuroscience 107:13-24. 2001
    ..We conclude that many of the characteristics of cortical neurons in vivo can be explained by fast glutamatergic and GABAergic conductances varying stochastically...
  15. ncbi Excitatory cortical neurons form fine-scale functional networks
    Yumiko Yoshimura
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 433:868-73. 2005
    ..Recording simultaneously from adjacent layer 2/3 pyramidal cells, we find that when they are connected to each other (20% of all recorded pairs) they share common input from ..
  16. ncbi Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells
    Gilad Silberberg
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Lausanne CH 1015, Switzerland
    Neuron 53:735-46. 2007
    ..We report a disynaptic inhibitory pathway among neocortical pyramidal cells (PCs)...
  17. ncbi Computational subunits in thin dendrites of pyramidal cells
    Alon Polsky
    Department of Physiology, Technion Medical School, Bat Galim, Haifa 31096, Israel
    Nat Neurosci 7:621-7. 2004
    ..Our findings could have important implications for the computing and memory-related functions of cortical tissue...
  18. pmc Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex
    H Markram
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Germany
    J Physiol 500:409-40. 1997
    ..neurones, which have their synaptic contacts preferentially located on basal and apical oblique dendrites, was due to differences in transmitter release probability of the projecting neurones and, to a lesser extent, to differenc..
  19. ncbi Heterogeneity in the pyramidal network of the medial prefrontal cortex
    Yun Wang
    Division of Neurology Research, Caritas St Elizabeth s Medical Center, Tufts University, Boston, Massachusetts 02135, USA
    Nat Neurosci 9:534-42. 2006
    ..medial prefrontal cortex showed a heterogeneity of synapses interconnecting distinct subnetworks of different pyramidal cells. One subnetwork was similar to the pyramidal network commonly found in primary sensory areas, consisting of ..
  20. ncbi Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience
    Kazu Nakazawa
    Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:305-15. 2003
    ..Here, we show that mice with NMDA receptor (NR) deletion restricted to CA3 pyramidal cells in adulthood are impaired in rapidly acquiring the memory of novel hidden platform locations in a delayed ..
  21. ncbi Pyramidal neurons: dendritic structure and synaptic integration
    Nelson Spruston
    Northwestern University, Department of Neurobiology and Physiology, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Nat Rev Neurosci 9:206-21. 2008
    ..These properties support a variety of coincidence-detection mechanisms, which are likely to be crucial for synaptic integration and plasticity...
  22. pmc Two forms of electrical resonance at theta frequencies, generated by M-current, h-current and persistent Na+ current in rat hippocampal pyramidal cells
    Hua Hu
    Institute of Physiology, University of Oslo, PB 1103 Blindern, 0317 Oslo, Norway
    J Physiol 545:783-805. 2002
    ..To study the mechanisms underlying theta-resonance, we performed whole-cell recordings from CA1 pyramidal cells (n = 73) in rat hippocampal slices...
  23. pmc Spine-neck geometry determines NMDA receptor-dependent Ca2+ signaling in dendrites
    Jun Noguchi
    Department of Cell Physiology, National Institute for Physiological Sciences and Graduate University of Advanced Studies SOKENDAI, Myodaiji, Okazaki 444 8787, Japan
    Neuron 46:609-22. 2005
    ..Spine-neck geometry is thus an important determinant of spine Ca2+ signaling, allowing small spines to be the preferential sites for isolated induction of long-term potentiation...
  24. ncbi Locally synchronized synaptic inputs
    Naoya Takahashi
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Science 335:353-6. 2012
    ..Thus, clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration...
  25. ncbi Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    Joshua T Trachtenberg
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 420:788-94. 2002
    ..Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits...
  26. ncbi Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons
    J C Magee
    Neuroscience Center, Louisiana State University Medical Center, New Orleans, Louisiana 70112, USA
    J Neurosci 18:7613-24. 1998
    ..Overall, Ih acts to dampen dendritic excitability, but its largest impact is on the subthreshold range of membrane potentials where the integration of inhibitory and excitatory synaptic inputs takes place...
  27. pmc Tonic inhibition in mouse hippocampal CA1 pyramidal neurons is mediated by alpha5 subunit-containing gamma-aminobutyric acid type A receptors
    Valerie B Caraiscos
    Institute of Medical Science, Department of Anesthesia, University of Toronto, Toronto, ON, Canada M5S 1A8
    Proc Natl Acad Sci U S A 101:3662-7. 2004
    ....
  28. ncbi Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks
    Andrea Hasenstaub
    Department of Neurobiology, Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 47:423-35. 2005
    ..We found that, during periods of recurrent network activity (UP states), cortical pyramidal cells in vivo and in vitro receive strong barrages of both excitatory and inhibitory postsynaptic potentials, with ..
  29. pmc Pyramidal cell communication within local networks in layer 2/3 of rat neocortex
    Carl Holmgren
    Karolinska Institute, Department of Neuroscience, Retzius vag 8, B2 2, S 17177 Stockholm, Sweden
    J Physiol 551:139-53. 2003
    The extent to which neocortical pyramidal cells function as a local network is determined by the strength and probability of their connections...
  30. pmc Distinct mechanisms regulate GABAA receptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells
    Patrizia Panzanelli
    Department of Anatomy, Pharmacology and Forensic Medicine and National Institute of Neuroscience Italy, University of Turin, Italy
    J Physiol 589:4959-80. 2011
    b>Pyramidal cells express various GABA(A) receptor (GABA(A)R) subtypes, possibly to match inputs from functionally distinct interneurons targeting specific subcellular domains...
  31. pmc Lateral competition for cortical space by layer-specific horizontal circuits
    Hillel Adesnik
    Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0634, USA
    Nature 464:1155-60. 2010
    ..Through this mechanism, cortical domains exploit horizontal projections to compete for cortical space...
  32. ncbi NMDA spikes in basal dendrites of cortical pyramidal neurons
    J Schiller
    Department of Physiology and Biophysics, Technion Medical School, Bat Galim, Haifa, Israel
    Nature 404:285-9. 2000
    ..In addition, NMDA spikes may serve as a powerful mechanism for modification of the cortical network by inducing long-term strengthening of co-activated neighbouring inputs...
  33. ncbi A new cellular mechanism for coupling inputs arriving at different cortical layers
    M E Larkum
    Abt Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    Nature 398:338-41. 1999
    ....
  34. pmc Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
    Christoph Kapfer
    Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 10:743-53. 2007
    ..The recruitment of these interneurons increases tenfold when they are excited by two pyramidal cells. A simple model demonstrates that the distribution of excitatory input amplitudes onto inhibitory neurons ..
  35. ncbi Regulation of neuronal input transformations by tunable dendritic inhibition
    Matthew Lovett-Barron
    Department of Neuroscience, Columbia University, New York, New York, USA
    Nat Neurosci 15:423-30, S1-3. 2012
    ..that dendritic inhibition is the primary regulator of input-output transformations in mouse hippocampal CA1 pyramidal cells, and acts by gating the dendritic electrogenesis driving burst spiking...
  36. pmc The determination of projection neuron identity in the developing cerebral cortex
    Dino P Leone
    Department of Biology, Stanford University, Stanford, CA 94305, USA
    Curr Opin Neurobiol 18:28-35. 2008
    ..The molecular mechanisms by which Satb2 regulates gene expression involves long-term epigenetic changes in chromatin configuration, which may enable cell fate decisions to be maintained during development...
  37. ncbi Potentiation of cortical inhibition by visual deprivation
    Arianna Maffei
    Department of Biology and Center for Behavioral Genomics, Brandeis University, Waltham, Massachusetts 02454, USA
    Nature 443:81-4. 2006
    ....
  38. pmc Genomic-anatomic evidence for distinct functional domains in hippocampal field CA1
    Hong Wei Dong
    Department of Neurology, Laboratory of Neuro Imaging, School of Medicine, University of California, Los Angeles, CA 90095 7334, USA
    Proc Natl Acad Sci U S A 106:11794-9. 2009
    ..Insights emerging from this genomic-anatomic approach provide a starting point for a detailed analysis of differential hippocampal structure-function organization...
  39. ncbi Experience leaves a lasting structural trace in cortical circuits
    Sonja B Hofer
    Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Nature 457:313-7. 2009
    ..These results provide a strong link between functional plasticity and specific synaptic rearrangements, revealing a mechanism of how prior experiences could be stored in cortical circuits...
  40. ncbi Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
    Darrell A Henze
    Center for Molecular and Behavioral Neuroscience, Rutgers University, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Nat Neurosci 5:790-5. 2002
    ..dentate granule cells, controlled intracellularly, generally failed to discharge either interneurons or CA3 pyramidal cells. In contrast, trains of spikes effectively discharged both CA3 cell types...
  41. ncbi Cell type-specific tuning of hippocampal interneuron firing during gamma oscillations in vivo
    John J Tukker
    Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom
    J Neurosci 27:8184-9. 2007
    ..The firing of bistratified cells, which target dendrites of pyramidal cells coaligned with the glutamatergic input from hippocampal area CA3, is strongly phase locked to field gamma ..
  42. ncbi Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex
    Joachim Lubke
    Research Centre Julich, Institute of Neurosciences and Biophysics INB 3, Leo Brandt Str, 52425 Julich, Germany
    Brain Struct Funct 212:3-17. 2007
    ..This review attempts to summarize recent advances in the study of individual microcircuits and their functional relevance within the framework of a cortical column, with emphasis on excitatory signal flow...
  43. ncbi Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory
    X J Wang
    Volen Center for Complex Systems, Department of Physics, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 19:9587-603. 1999
    ..This result suggests a critical role of the NMDA receptor channels in normal working memory function of the prefrontal cortex...
  44. ncbi Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces
    Laurent Badel
    Laboratory of Computational Neuroscience, School of Computer and Communication Sciences and Brain Institute, Lausanne, Switzerland
    J Neurophysiol 99:656-66. 2008
    ..We apply this technique to layer-5 pyramidal cells and show that their dynamic I-V curve comprises linear and exponential components, providing experimental ..
  45. ncbi Activity deprivation reduces miniature IPSC amplitude by decreasing the number of postsynaptic GABA(A) receptors clustered at neocortical synapses
    Valerie Kilman
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02454, USA
    J Neurosci 22:1328-37. 2002
    ..Because excitatory and inhibitory synaptic currents are regulated in opposite directions by activity blockade, these data suggest that the balance between excitation and inhibition is dynamically regulated by ongoing activity...
  46. ncbi Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
    J J Radley
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 125:1-6. 2004
    ....
  47. ncbi Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells
    M Megias
    Institute of Experimental Medicine, Hungarian Academy of Sciences, P O Box, H 1450, Budapest, Hungary
    Neuroscience 102:527-40. 2001
    ..of symmetrical and asymmetrical synapses on different cellular compartments of rat hippocampal CA1 area pyramidal cells was measured to calculate the total number and distribution of excitatory and inhibitory inputs on a single ..
  48. ncbi Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior
    H Christian Peters
    Institut für Neurale Signalverarbeitung, Zentrum fur Molekulare Neurobiologie Hamburg, Martinistrasse 52, 20246 Hamburg, Germany
    Nat Neurosci 8:51-60. 2005
    ..M channels are thus critical determinants of cellular and neuronal network excitability, postnatal brain development and cognitive performance...
  49. pmc Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
    Lindsey L Glickfeld
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 12:21-3. 2009
    ..to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.
  50. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
    ..These data support the conclusion that KCC2 is the main Cl- extruder to promote fast hyperpolarizing postsynaptic inhibition in the brain...
  51. ncbi Identified sources and targets of slow inhibition in the neocortex
    Gabor Tamas
    Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Science 299:1902-5. 2003
    ..Slow inhibition evoked by a distinct interneuron in spatially restricted postsynaptic compartments could locally and selectively modulate cortical excitability...
  52. pmc Strong CA2 pyramidal neuron synapses define a powerful disynaptic cortico-hippocampal loop
    Vivien Chevaleyre
    Department of Neuroscience, Kavli Institute for Brain Science, Howard Hughes Medical Institute, Columbia University, New York, NY 10032, USA
    Neuron 66:560-72. 2010
    ..This circuit is likely to mediate key aspects of hippocampal-dependent spatial memory...
  53. ncbi Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses
    R I Wilson
    Nature 410:588-92. 2001
    ..Signalling by the endocannabinoid system thus represents a mechanism by which neurons can communicate backwards across synapses to modulate their inputs...
  54. ncbi A frequency-dependent switch from inhibition to excitation in a hippocampal unitary circuit
    Masahiro Mori
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nature 431:453-6. 2004
    ..Thus, the powerful mossy fibre input to CA3 pyramidal cells might mediate both synaptic excitation and inhibition...
  55. ncbi Place cells and place recognition maintained by direct entorhinal-hippocampal circuitry
    Vegard H Brun
    Neuroscience Unit, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 296:2243-6. 2002
    ..b>Pyramidal cells in the isolated CA1 area developed sharp and stable place fields...
  56. ncbi Brain-state- and cell-type-specific firing of hippocampal interneurons in vivo
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, Oxford University, Mansfield Road, Oxford OX1 3TH, UK
    Nature 421:844-8. 2003
    ..Interneurons also entrain pyramidal cells in vitro...
  57. pmc Nectin: an adhesion molecule involved in formation of synapses
    Akira Mizoguchi
    Department of Anatomy and Neurobiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 156:555-65. 2002
    ..We show here that at the synapses between the mossy fiber terminals and dendrites of pyramidal cells in the CA3 area of adult mouse hippocampus, the nectin-afadin system colocalizes with the cadherin-catenin ..
  58. ncbi Perisomatic feedback inhibition underlies cholinergically induced fast network oscillations in the rat hippocampus in vitro
    Edward O Mann
    University Laboratory of Physiology, Oxford University, Parks Road, Oxford OX1 3PT, UK
    Neuron 45:105-17. 2005
    ..These proximal currents were driven by phase-locked rhythmic inhibitory inputs to pyramidal cells from identified perisomatic-targeting interneurons...
  59. ncbi Input normalization by global feedforward inhibition expands cortical dynamic range
    Frederic Pouille
    Howard Hughes Medical Institute and Neurobiology Section, Division of Biology, University of California San Diego, La Jolla, California, USA
    Nat Neurosci 12:1577-85. 2009
    ..We found that the amplitude of excitatory synaptic currents necessary to fire rodent pyramidal cells, the threshold excitatory current, increased with stimulus strength...
  60. ncbi Temporal interaction between single spikes and complex spike bursts in hippocampal pyramidal cells
    K D Harris
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Neuron 32:141-9. 2001
    Cortical pyramidal cells fire single spikes and complex spike bursts. However, neither the conditions necessary for triggering complex spikes, nor their computational function are well understood...
  61. pmc Alteration of theta timescale dynamics of hippocampal place cells by a cannabinoid is associated with memory impairment
    David Robbe
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    J Neurosci 29:12597-605. 2009
    ..We hypothesize that precise temporal coordination of hippocampal neurons is necessary for guiding behavior in spatial memory tasks...
  62. ncbi Compartmentalized dendritic plasticity and input feature storage in neurons
    Attila Losonczy
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Dr Ashburn, Virginia 20147, USA
    Nature 452:436-41. 2008
    ....
  63. ncbi Reconstruct: a free editor for serial section microscopy
    J C Fiala
    Department of Biology, Boston University, Boston, MA, USA
    J Microsc 218:52-61. 2005
    ..As a flexible editor, Reconstruct can reduce the time and resources expended for serial section studies and allows a larger tissue volume to be analysed more quickly...
  64. pmc Independent rate and temporal coding in hippocampal pyramidal cells
    John Huxter
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 425:828-32. 2003
    In the brain, hippocampal pyramidal cells use temporal as well as rate coding to signal spatial aspects of the animal's environment or behaviour...
  65. ncbi The development of hippocampal interneurons in rodents
    Lydia Danglot
    Laboratoire de Biologie de la Synapse Normale et Pathologique, Unité Inserm U789, Ecole Normale Superieure, 46 rue d Ulm, 75005 Paris, France
    Hippocampus 16:1032-60. 2006
    ..We will finally review potential mechanisms underlying the development of GABAergic interneurons...
  66. ncbi Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential
    Yousheng Shu
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 441:761-5. 2006
    ....
  67. ncbi Increased attention to spatial context increases both place field stability and spatial memory
    Clifford G Kentros
    Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    Neuron 42:283-95. 2004
    ..We propose a model whereby attention provides the requisite neuromodulatation to switch short-term homosynaptic plasticity to long-term heterosynaptic plasticity, and we implicate dopamine in this process...
  68. ncbi Deletion of Kv4.2 gene eliminates dendritic A-type K+ current and enhances induction of long-term potentiation in hippocampal CA1 pyramidal neurons
    Xixi Chen
    Center for Learning and Memory, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 26:12143-51. 2006
    ..2 knock-out and wild-type neurons. Our results support the hypothesis that dendritic A-type K+ channels, composed of Kv4.2 subunits, regulate action potential backpropagation and the induction of specific forms of synaptic plasticity...
  69. ncbi Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling
    Yu Kasugai
    Department of Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies Sokendai, Okazaki, Japan
    Eur J Neurosci 32:1868-88. 2010
    Hippocampal CA1 pyramidal cells, which receive γ-aminobutyric acid (GABA)ergic input from at least 18 types of presynaptic neuron, express 14 subunits of the pentameric GABA(A) receptor...
  70. ncbi Layer V neurons in mouse cortex projecting to different targets have distinct physiological properties
    Alexis M Hattox
    Department of Biology, MS 008, Brandeis University, Waltham, MA 02454, USA
    J Neurophysiol 98:3330-40. 2007
    ....
  71. ncbi Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons
    Miguel Remondes
    Caltech Howard Hughes Medical Institute, Division of Pasadena, CA 91125, USA
    Nature 416:736-40. 2002
    ..This capacity for bi-directional plasticity can, in turn, regulate the TA modulation of CA1 activity: LTP or LTD of the TA pathway either enhances or diminishes the gating of CA1 spikes and plasticity inhibition, respectively...
  72. ncbi Timing and location of nicotinic activity enhances or depresses hippocampal synaptic plasticity
    D Ji
    Division of Neuroscience and, Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, One Baylor Plaza, 77030, Houston, TX, USA
    Neuron 31:131-41. 2001
    ..Loss of these synaptic mechanisms may contribute to the cognitive deficits experienced during Alzheimer's diseases, which is associated with a loss of cholinergic projections and with a decrease in the number of nicotinic receptors...
  73. ncbi Heterosynaptic LTD of hippocampal GABAergic synapses: a novel role of endocannabinoids in regulating excitability
    Vivien Chevaleyre
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neuron 38:461-72. 2003
    ..by repetitive activation of Schaffer collaterals activates group I metabotropic glutamate receptors at CA1 pyramidal cells, triggering a persistent reduction of GABA release that is mediated by endocannabinoids...
  74. ncbi State-dependent dendritic computation in hippocampal CA1 pyramidal neurons
    Sonia Gasparini
    Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Neurosci 26:2088-100. 2006
    ....
  75. pmc Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
    Dirk Feldmeyer
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 538:803-22. 2002
    ..voltage recordings were obtained from 64 synaptically coupled excitatory layer 4 (L4) spiny neurones and L2/3 pyramidal cells in acute slices of the somatosensory cortex ('barrel' cortex) of 17- to 23-days-old rats...
  76. ncbi On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons
    Sonia Gasparini
    Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Neurosci 24:11046-56. 2004
    ..Therefore, dendritic spikes function as efficient detectors of specific input patterns, ensuring that the neuronal response to high levels of input synchrony is a precisely timed action potential output...
  77. pmc Cholinergic neuromodulation changes phase response curve shape and type in cortical pyramidal neurons
    Klaus M Stiefel
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California, United States of America
    PLoS ONE 3:e3947. 2008
    ..This is the first report showing that cholinergic neuromodulation may cause a qualitative switch in the PRCs type implying a change in the fundamental dynamical mechanism of spike generation...
  78. pmc Seizure-induced plasticity of h channels in entorhinal cortical layer III pyramidal neurons
    Mala M Shah
    Division of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 44:495-508. 2004
    ..Our results suggest that dendritic I(h) plays an important role in determining the excitability of EC layer III neurons and their associated neural networks...
  79. ncbi Spike timing of distinct types of GABAergic interneuron during hippocampal gamma oscillations in vitro
    Norbert Hajos
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest H 1450, Hungary
    J Neurosci 24:9127-37. 2004
    ..b>Pyramidal cells fired at 2.82 +/- 0.7 Hz, close to the negative peak of the oscillation (0.03 +/- 0...
  80. ncbi Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation
    Wenqin Hu
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Neurosci 12:996-1002. 2009
    ..Further modeling studies and simultaneous somatic and axonal recordings showed that distal Na(v)1.6 promotes action potential initiation, whereas proximal Na(v)1.2 promotes its backpropagation to the soma...
  81. ncbi Predicting spike timing of neocortical pyramidal neurons by simple threshold models
    Renaud Jolivet
    Ecol Polytechnique Federale de Lausanne EPFL, School of Computer and Communication Sciences and Brain Mind Institute, Station 15, CH 1015, Lausanne, Switzerland
    J Comput Neurosci 21:35-49. 2006
    ....
  82. ncbi The gamma cycle
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Neurosci 30:309-16. 2007
    ..review evidence suggesting that the resulting rhythmic network inhibition interacts with excitatory input to pyramidal cells such that the more excited cells fire earlier in the gamma cycle...
  83. ncbi Outwardly rectifying tonically active GABAA receptors in pyramidal cells modulate neuronal offset, not gain
    Ivan Pavlov
    UCL Institute of Neurology, University College London, London WC1 N3BG, United Kingdom
    J Neurosci 29:15341-50. 2009
    ..Here we show that tonically active GABA(A) receptors in CA1 pyramidal cells show marked outward rectification, while the peaks of IPSCs exhibit a linear current-voltage relationship...
  84. ncbi Axon initial segment Kv1 channels control axonal action potential waveform and synaptic efficacy
    Maarten H P Kole
    Division of Neuroscience, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Neuron 55:633-47. 2007
    ..Thus, Kv1 channels are strategically positioned to integrate slow subthreshold signals, providing control of the presynaptic action potential waveform and synaptic coupling in local cortical circuits...
  85. ncbi Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy
    Rimante Minkeviciene
    A I Virtanen Institute, University of Kuopio, FIN 70211 Kuopio, Finland
    J Neurosci 29:3453-62. 2009
    ..In APdE9 mice, persistently decreased resting membrane potential in neocortical layer 2/3 pyramidal cells and dentate granule cells underpinned increased network excitability as identified by patch-clamp ..
  86. ncbi Pathway interactions and synaptic plasticity in the dendritic tuft regions of CA1 pyramidal neurons
    Hiroto Takahashi
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 62:102-11. 2009
    ....
  87. pmc Projections from basal forebrain to prefrontal cortex comprise cholinergic, GABAergic and glutamatergic inputs to pyramidal cells or interneurons
    Pablo Henny
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec, Canada H3A 2B4
    Eur J Neurosci 27:654-70. 2008
    ..were triple-stained for cell marker proteins to assess whether the varicosities contacted interneurons or pyramidal cells. Viewed by confocal microscopy, BDA-labelled VGluT2+, VGAT+ and VAChT+ BF terminals were all found in contact ..
  88. pmc Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex
    Michael Brecht
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    J Physiol 543:49-70. 2002
    ..Three classes of neurons were identified: spiny stellate cells and pyramidal cells located in barrels and pyramidal cells located in septa...
  89. ncbi Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study
    Thomas Nevian
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Nat Neurosci 10:206-14. 2007
    ....
  90. ncbi Turning on and off recurrent balanced cortical activity
    Yousheng Shu
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 423:288-93. 2003
    ..These results confirm the long-hypothesized role of recurrent activity as a basic operation of the cerebral cortex...
  91. ncbi Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus
    Roger J Thompson
    Department of Psychiatry and Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC V6T 2B5, Canada
    Science 322:1555-9. 2008
    ..We conclude that Px1 hemichannel opening is triggered by NMDAR stimulation and can contribute to epileptiform seizure activity...
  92. pmc Intracortical circuits of pyramidal neurons reflect their long-range axonal targets
    Solange P Brown
    Department of Comparative Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Edwards Building, R314, Stanford, California 94305 5342, USA
    Nature 457:1133-6. 2009
    ..The selective synaptic interactions we describe demonstrate that the organization of local networks of pyramidal cells reflects the long-range targets of both the presynaptic and postsynaptic neurons.
  93. ncbi Dark rearing alters the development of GABAergic transmission in visual cortex
    Bernardo Morales
    Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland 21218, USA
    J Neurosci 22:8084-90. 2002
    ..critical period for experience-dependent plasticity, the total GABAergic input converging into layer II/III pyramidal cells increases threefold...
  94. pmc Place-selective firing contributes to the reverse-order reactivation of CA1 pyramidal cells during sharp waves in open-field exploration
    Jozsef Csicsvari
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Eur J Neurosci 26:704-16. 2007
    ..significantly different in familiar and novel environments, even though SWR-associated firing rates of both pyramidal cells and interneurons were reduced in novel environments as compared with familiar...
  95. ncbi Top-down dendritic input increases the gain of layer 5 pyramidal neurons
    Matthew E Larkum
    Institute of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Cereb Cortex 14:1059-70. 2004
    ..We propose that this dendritic gain modulation and the timing of bursts may serve to associate top-down and bottom-up input on different time scales...
  96. pmc Large identified pyramidal cells in macaque motor and premotor cortex exhibit "thin spikes": implications for cell type classification
    Ganesh Vigneswaran
    Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 31:14235-42. 2011
    ..In summary, one class of physiologically identified cortical pyramidal neuron exhibits a wide variety of spike durations and the results suggest that spike duration alone may not be a reliable indicator of cell type...
  97. pmc Dopamine D1/D5 receptor modulation of excitatory synaptic inputs to layer V prefrontal cortex neurons
    J K Seamans
    Howard Hughes Medical Institute and Molecular and Computational Neurobiology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 98:301-6. 2001
    ..By increasing the NMDA component of EPSCs, yet slightly reducing release, D1/D5 receptor activation selectively enhanced sustained synaptic inputs and equalized the sizes of EPSPs in a 20-Hz train...
  98. pmc Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus
    Detlef Vullhorst
    Section on Molecular Neurobiology, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892 3714, USA
    J Neurosci 29:12255-64. 2009
    ..However, despite much attention this pathway and its effects on pyramidal cells have received recently, the presence of ErbB4 in these cells is still controversial...
  99. pmc Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury
    Masato Koike
    Department of Cell Biology and Neurosciences, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Am J Pathol 172:454-69. 2008
    ....
  100. ncbi A behavioral role for dendritic integration: HCN1 channels constrain spatial memory and plasticity at inputs to distal dendrites of CA1 pyramidal neurons
    Matthew F Nolan
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Cell 119:719-32. 2004
    ..inward current (Ih) and is an important determinant of dendritic integration in hippocampal CA1 pyramidal cells. Deletion of HCN1 from forebrain neurons enhances hippocampal-dependent learning and memory, augments the ..
  101. ncbi Local structural balance and functional interaction of excitatory and inhibitory synapses in hippocampal dendrites
    Guosong Liu
    Picower Centre for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 7:373-9. 2004
    ..These fundamental relationships among E/I synapses provide organizational principles relevant to deciphering the structural and functional basis for neural computation within dendritic branches...

Research Grants73

  1. Kainate Receptors on Hippocampal Interneurons
    Matthew Frerking; Fiscal Year: 2007
    Inhibitory interneurons in the hippocampus regulate pyramidal cells and prevent hyperexcitability that leads to epileptiform activity. Glutamatergic transmission onto interneurons activates these cells to drive these functions...
  2. Chemical modulators of Tet-family proteins
    Anjana Rao; Fiscal Year: 2010
    ..mRNA are expressed in the brain, with TET1 mRNA being particularly high in Purkinje cells and hippocampal pyramidal cells. Together these data suggest potential functions of TET proteins and hmC in (a) pluripotency and stem cell ..
  3. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..We propose to test in Specific Aim 1 the hypothesis that direct virus infection of pyramidal cells of the hippocampus leads to the development of seizures...
  4. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..are thought to come about as interactions of parvalbumin positive (PV+) fast-spiking (FS) interneurons and pyramidal cells. However, it is known that other cell types, especially interneurons, participate in gamma rhythms and/or may ..
  5. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
    ..and 4 will use Fmr1-KO and WT mice that constitutively express yellow fluorescent protein (YFP) in scattered pyramidal cells to provide a bright label of dendritic spines...
  6. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
    ..collateral pathway but also include synapses between the entorhinal cortex and the distal dendrites of CA1 pyramidal cells;AIM3 will test the hypothesis that cholinergic denervation will prevent the E2 induced increase in spine ..
  7. STRESS-OPIOID INTERACTION IN HIPPOCAMPUS
    Teresa A Milner; Fiscal Year: 2013
    ..estrogen): 1) enkephalin levels are elevated in mossy fibers (MFs), which synapse on the dendrites of CA3 pyramidal cells;2) increased MORs are present on the plasma membrane of parvalbumin GABAergic interneurons, which inhibit CA3 ..
  8. PET and MRI Neuronal Loss and Amyloid and Tau Deposition in Alzheimer Disease
    Laurel Martin-Harris; Fiscal Year: 2012
    ..tangle deposition;the second, [F18]MPPF binds to the serotionin 1A receptor, found specifically in pyramidal cells of the HC, and can be used as a measure of HC neuronal loss...
  9. GABA-A Receptor Pharmacology of Neural Coding in Hippocampal Place Cells
    TARA MONIQUE STEWART; Fiscal Year: 2012
    ..builds upon the phenomenon that the animal[unreadable]s physical location is encoded by hippocampal pyramidal cells (HPCs), such that firing rates for HPCs correlate with location in physical space...
  10. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..My laboratory recently published the first functional evidence that TRPV1 channels are present on hippocampal pyramidal cells. Using electrophysiological methods in brain slices, we found that TRPV1 channels are essential for a form of ..
  11. G Protein Coupled Receptor Modulation of Synaptic Transmission
    EDAENI YISHAK HAMID; Fiscal Year: 2010
    ..In hippocampus, the 5-HT1B receptor is expressed on presynaptic terminals of CA1 pyramidal cells that synapse locally and also project to the subiculum and entorhinal cortex...
  12. Alcohol and Development of the Prefrontal Cortex
    LEON GARLAND COLEMAN; Fiscal Year: 2011
    ..cortical structure following prenatal treatment using neuron specific markers for GABA interneurons and pyramidal cells;2...
  13. Mapping the Inputs onto Neocortical Chandelier Cells
    Jason M Tucciarone; Fiscal Year: 2013
    ..Further, a single ChC innervates hundreds of pyramidal cells in cortex...
  14. Regulation of Cholinergic Transmission and Theta Rhythms by Endocannabinoids
    DANIEL ALAN NAGODE; Fiscal Year: 2012
    ..how endocannabinoids regulate cholinergically-driven theta frequency inhibition in hippocampal CA1 pyramidal cells. The results will establish a new optogenetic model for the study of endogenous ACh in hippocampal slice ..
  15. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    JOHN WILLIAM SWANN; Fiscal Year: 2012
    ..These effects are not explained by the death of neurons. However, dendritic abnormalities in hippocampal pyramidal cells - including a reduction in dendritic branching - have been reported...
  16. Consequences of In Vivo Neocortical GAD67 Downregulation
    Karoly Mirnics; Fiscal Year: 2012
    ..in specific interneuronal subpopulations will likely lead to expression changes in both interneurons and pyramidal cells, and we believe that some of these expression changes will mimic the expression changes seen in human ..
  17. Maternal smoking and hippocampal circuits
    Katumi Sumikawa; Fiscal Year: 2010
    ..Hippocampal CA1 pyramidal cells, which provide the major output of the hippocampus, receive two major excitatory synaptic inputs directly or ..
  18. RGS proteins as novel integrators of G protein and MAPK signaling
    John R Hepler; Fiscal Year: 2013
    ..e. pyramidal cells of the CA1/CA2 region)...
  19. GABA and Early Intervention of Schizophrenia
    Tsung Ung W Woo; Fiscal Year: 2010
    ..synaptic pruning, leading to excessive loss of synapses and (2) Reduced GABA inhibition may disinhibit pyramidal cells, making them prone to excitotoxic injury, which can be manifested as dendritic shrinkage and synaptic ..
  20. Mechanisms of Associative Learning in Aging: Mouse Models
    Diana S Woodruff Pak; Fiscal Year: 2010
    ..In hippocampus- dependent learning and memory, aging is associated with reduced functional capacity of CA1 pyramidal cells, but neuron number is stable...
  21. Maternal nicotine exposure and development of hippocampal circuits
    Katumi Sumikawa; Fiscal Year: 2013
    ..Hippocampal CA1 pyramidal cells, which provide the major output of the hippocampus, receive two major excitatory synaptic inputs either ..
  22. Role of neuroligins in long-term plasticity at excitatory and inhibitory synapses
    Holly Sue Engelman; Fiscal Year: 2010
    ..WT littermates, while monitoring inhibitory postsynaptic currents (IPSCs) via whole cell recording from CA1 pyramidal cells. In addition, recordings will be performed in which the pipette solution will contain either the activated ..
  23. Integration of ascending and descending input to auditory cortex
    Matthew I Banks; Fiscal Year: 2013
    ..We will investigate the integration of ascending and descending inputs in pyramidal cells of layer 2/3 and layer 5, we will characterize the modulation of spatiotemporal activation patterns by ..
  24. Mechanisms Underlying Activity-Dependent Interneuron Development
    NATALIA VANESA DE MARCO GARCIA; Fiscal Year: 2013
    ..present during this time include Cajal-Retzius cells, glutamatergic transient cells, subplate cells and pyramidal cells. Due to thei spatial and temporal distribution, these cohorts are well suited to provide interneurons with ..
  25. Mechanisms of amphetamine-induced plasticity in adolescents compared to adults
    Joshua M Gulley; Fiscal Year: 2013
    ..behavior on an mPFC-sensitive working memory task and alters the intrinsic firing properties of layer V pyramidal cells recorded in vitro...
  26. Understanding the role of sodium channels in epilepsy
    ANDREW P ESCAYG; Fiscal Year: 2013
    ..However, a direct causal link between SCN1A function in interneurons or pyramidal cells and seizure generation has not yet been established...
  27. Dopaminergic Regulation of Pyramidal Cells
    Ariel Y Deutch; Fiscal Year: 2013
    ..applicant): Among the structural changes present in schizophrenia is a decrease in dendritic spine density of pyramidal cells (PCs) in the prefrontal cortex (PFC)...
  28. Serotonin-limbic system interactions that mediate anxiety
    Sheryl G Beck; Fiscal Year: 2013
    ..SP2: To determine the developmental profile of layer 5 pyramidal cells in the mPFC in 5-HT1A and Pet-1 knockout mice...
  29. PHYSIOLOGY OF DORSAL COCHLEAR NUCLEUS MOLECULAR LAYER
    Paul B Manis; Fiscal Year: 2011
    ..While the responses of DCN principal neurons (pyramidal cells) to sound are strongly molded by inhibition, little is known about the functional operation of the major ..
  30. MECHANISMS OF SYNAPTIC PLASTICITY IN THE HIPPOCAMPUS
    Robert C Malenka; Fiscal Year: 2012
    ..levels as well as express a "replacement" version of wildtype or mutant complexin in single hippocampal pyramidal cells in vivo or in vitro...
  31. Virtual Realty Systems for Neural Circuit Dynamics
    David W Tank; Fiscal Year: 2010
    ..By combining VR with two-photon imaging, the capability for monitoring populations of hippocampal pyramidal cells during navigation is also demonstrated...
  32. Cell type-specific calcium imaging during hippocampus-dependent memory
    Larry S Zweifel; Fiscal Year: 2013
    ..indicator will be conditionally expressed in transgenic mice selectively expressing Cre recombinase in CA1 pyramidal cells, or in dentate granule cells and CA3 pyramidal cells...
  33. CALCIUM WAVES IN PYRAMIDAL NEURONS
    William Ross; Fiscal Year: 2009
    ..We will investigate the properties and functions of Ca2+ released from stores mediated by IP3 in pyramidal cells in slices from the CA1 region of the hippocampus in Sprague Dawley rats...
  34. Parsing the schizophrenia-bipolar spectrum: an MEG based schizoaffective endophen
    Martin Reite; Fiscal Year: 2010
    ..to estimate functional status of GABAergic interneuronal activity regulating firing patterns of layer 3 pyramidal cells in auditory cortex of Heschl's gyrus...
  35. SYNAPTIC ORGANIZATION OF THE BASOLATERAL AMYGDALA
    Alexander Joseph McDonald; Fiscal Year: 2012
    ..Specific Aim #2 will study the Innervation of pyramidal cells and distinct interneuronal subpopulations by noradrenergic inputs to the BLC...
  36. Molecular Components of A-type K+ Channels
    Bernardo Rudy; Fiscal Year: 2013
    ..This application is focused in CA1 hippocampal pyramidal cells, neurons that are important in spatial learning and in the pathogenesis of epilepsy, and prominently express ..
  37. Mechanisms of neuroprotection against cardiac arrest
    Miguel A Perez-Pinzon; Fiscal Year: 2013
    ..methods to directly evaluate the impact of cardiac arrest and manipulations of ? PKC on hippocampal pyramidal cells, interneurons, and microvessels. We propose to test this general hypothesis in the following 4 specific aims...
  38. Scn8a and Seizure Resistance
    Alan L Goldin; Fiscal Year: 2012
    ..This will be accomplished by selectively deleting Scn8a from either pyramidal cells or interneurons in the cortex and hippocampus, and then evaluating the mice for elevated seizure thresholds ..
  39. Assay development for cellular RGS7 family modulators
    Richard Neubig; Fiscal Year: 2009
    ..RGS9 play a key role in dopamine signaling and reward pathways while RGS7 is highly expressed in hippocampal pyramidal cells where it is poised to modulate learning and memory and neuronal excitability underlying epilepsy...
  40. MODULATION OF NEOCORTICAL INTERNEURONAL FUNCTION
    DAVID ALLAN PRINCE; Fiscal Year: 2013
    ..cortical connectivity;paired recordings to examine unitary IPSCs from interneurons to other interneurons and pyramidal cells;use of genetically engineered mice with GFP label in specific interneuron species;and local application or ..
  41. Development of the Cerebral Cortex in Mammals
    NADA R ZECEVIC; Fiscal Year: 2013
    ..Having available to us a well- characterized collection of human fetal brains, an opportunity to obtain fresh tissue, and expertise in this field, we are in a favorable position to perform proposed experiments. ..
  42. Cognitive maps and novel behavioral sequences in the hippocampus
    ANOOPUM SATYAWAN GUPTA; Fiscal Year: 2012
    ..model system because it is relatively easy to access with electrodes, and because the firing of hippocampal pyramidal cells has a clear behavioral correlate: the animal's location in an environment...
  43. Rescue of cortical inhibitory synapses following developmental hearing loss
    DAN HARVEY SANES; Fiscal Year: 2013
    ..be recorded in a thalamocortical brain slice, including paired recordings between inhibitory interneurons and pyramidal cells. Aim 2 will determine whether inhibitory synapse deficits induced by developmental CHL can impair auditory ..
  44. Dopamine D2 Receptors in Prefrontal Function: An Optogenetic and Modeling Study
    IAN THOMAS ELLWOOD; Fiscal Year: 2013
    ..D2R-expressing neurons in mouse PFC and discovered two major results: (1) The population of D2R-expressing pyramidal cells in layer V PFC is coincident with a previously identified population of thick-tufted, subcortically ..
  45. Role of Synaptotagmins in Synaptic Plasticity in the Hippocampus
    Di Wu; Fiscal Year: 2013
    ..This study will use in vivo viral-mediated knockdown and replacement of synaptotagmins in CA1 pyramidal cells of the hippocampus...
  46. Cognitive Recovery and Neuronal Plasticity after Stroke in the Aged
    REBECCA LYNN GILLANI; Fiscal Year: 2010
    ..Neurons in the hippocampus (CA1 pyramidal cells, CAS pyramidal cells, and DG granule cells) and entorhinal cortex (layer II stellate cells, layer III ..
  47. Slowly Inactivating K+ Channels in Neocortical Pyramidal Cells
    ROBERT C FOEHRING; Fiscal Year: 2013
    ..We focus on the functional consequences of voltage-gated potassium channel (Kv) diversity in neocortical pyramidal cells from somatosensory cortex...
  48. Ionic Cell Signaling in Small Spaces
    Terrence J Sejnowski; Fiscal Year: 2012
    ..explore three components of synaptic signaling: 1) calcium dynamics in the presynaptic boutons from area CA3 pyramidal cells in the rat hippocampus, 2) calcium microdomains in the vicinity of ligand-gated ion channels in postsynaptic ..
  49. Presynaptic receptors and analog signaling in the CNS
    Craig E Jahr; Fiscal Year: 2013
    ..dissimilar neurons, cerebellar molecular layer interneurons, dentate gyrus granule cells and cortical layer 5 pyramidal cells. The proposed mechanisms for orthodromic signaling in these three cells types are contradictory but include ..
  50. Synchronous Activity in Hybrid Neuronal Microcircuits
    John A White; Fiscal Year: 2013
    ..Additional proposed studies focus on the consequences of O-LM-cell projections to the distal dendrites of pyramidal cells, as well as the consequences of O-LM-cell loss for the theta rhythm in vivo and in vitro...
  51. SHH signaling and Interneuron progenitors in human subventricular zone
    NADA R ZECEVIC; Fiscal Year: 2012
    ..Cortical interneurons provide inhibitory input to pyramidal cells, and are necessary for normal function of the cerebral cortex...
  52. GLUTAMATE receptors in aging cortical circuits
    John H Morrison; Fiscal Year: 2013
    ..The current Specific Aims are: 1) To determine the age-related morphologic and molecular alterations in pyramidal cells and axospinous synapses in area 46 of dorsolateral prefrontal cortex (dlPFC) in rhesus monkey and their ..
  53. Testing the Hemo-Neural Hypothesis: Tetrode, Two-photon &Computational Studies
    Dorea Vierling-Claassen; Fiscal Year: 2012
    ..These techniques will be used to test the activation of fast spiking interneurons and pyramidal cells in baseline and pharmacalogically induced hyperemia...
  54. Seizure generation and network excitability in Arx related Infantile Spasms
    Eric D Marsh; Fiscal Year: 2013
    ..Our preliminary data demonstrates hyperexcitability in the DG and CA3, and loss of inhibition onto CA1 pyramidal cells. To extend these findings and elucidate the mechanisms of infantile spasms, three series of experiments are ..
  55. Mechanisms underlying reward-related synaptogenesis
    Gloria E Meredith; Fiscal Year: 2010
    ..We believe that drug-seeking behavior therefore requires both structural and functional plasticity of BLA pyramidal cells to consolidate the learned association of drug and environment...
  56. Frequency Dependence of Excitatory Synaptic Transmission
    LYNN DOBRUNZ; Fiscal Year: 2009
    ..In hippocampus, GABAergic interneurons provide powerful inhibition to the excitatory pyramidal cells that is vital to prevent epilepsy and excitotoxicity...
  57. Mapping the escape from inhibition.
    Kevin J Staley; Fiscal Year: 2013
    ..Here we propose to combine channelrhodopsin-mediated photoactivation of targeted pyramidal cells with high-speed multiphoton imaging of the responses in interneurons expressing the calcium fluorophore ..
  58. Retrotransposons in Schizophrenia
    Wade H Berrettini; Fiscal Year: 2013
    ..Using laser capture microdissection of parvalbumin positive interneurons and their target pyramidal cells of dorsolateral prefrontal cortex, followed by high-throughput sequencing, detection of novel L1 RTP ..
  59. Role of dentate gyrus gating and neurogenesis in the pathophysiology of mild TBI
    Candace L Floyd; Fiscal Year: 2013
    ..function is essential for propagating sparse representation of cortical sensory signals to downstream pyramidal cells and is achieved by strong local inhibitory circuitry...
  60. Cannabis and Adolescent Brain Development
    David A Lewis; Fiscal Year: 2012
    ..terminals converge with inputs from parvalbumin (PV)-containing GABA neurons onto the perisomatic region of pyramidal cells, and these two sources of perisomatic inputs play complementary roles in the synchronization of pyramidal ..
  61. Regulation and Modulation of Postysynaptic NMDA Receptors by Extracellular pH
    Sachin Makani; Fiscal Year: 2009
    ..knocked out demonstrated that either isoform can catalyze buffering near the cell bodies of hippocampal pyramidal cells. It remains unknown whether one or both of these enzymes catalyzes buffering of the local, synaptically-..
  62. Neurophysiological mechanisms of cognitive impairment in Severe Myoclonic Epileps
    ALEX COLBATH BENDER; Fiscal Year: 2013
    ..deficits cause impaired action potential firing of parvalbumin-positive (PV+) interneurons but not excitatory pyramidal cells. In addition to the contribution of this cell type to balancing excitation and inhibition in the brain, PV+ ..
  63. Interactions Among Hippocampal Interneuron Circuits
    Bradley E Alger; Fiscal Year: 2012
    ..CCK systems mutually interact via hippocampal interneurons and thereby jointly regulate the excitability of pyramidal cells. Low frequency neuronal population oscillations (especially theta "?", 4-12 Hz, and gamma "?", 30-80 Hz, ..
  64. ANATOMY OF IDENTIFIED CELL POPULATIONS IN VISUAL CORTEX
    BARBARA MC GUIRE; Fiscal Year: 1991
    ..The cells to be studied are Meynert cells and layer 4B cells. Meynert cells are the largest pyramidal cells in striate cortex, located at the layer 5/6 border...
  65. Role of serotonin in auditory cortex regulation following early-onset sensorineur
    GREGORY BASURA; Fiscal Year: 2009
    ..Electrophysiologic traces from A1 pyramidal cells have been recorded in the presence of extra-cellular 5-HT application, as well as 5-HT2 receptor antagonists...
  66. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..b>Pyramidal cells in CA1 are the most sensitive; CA3 and granule cells of the dentate gyrus (DG) are resistant to ischemic ..
  67. RAT MODEL OF FETAL ALCOHOL SYNDROME
    ASA BLACK; Fiscal Year: 1993
    ..Muscarinic cholinergic neurons in the medial septal nucleus and nucleus of the diagonal band synapse on pyramidal cells and dentate gyrus cells...
  68. LONG-TERM DEPRESSION IN THE ADULT HIPPOCAMPUS
    THOMAS O DELL; Fiscal Year: 1999
    ..of the brain important for some types of learning and memory, the strength of excitatory synapses onto CA1 pyramidal cells is persistently altered following certain patterns of synaptic activity...
  69. LONG-TERM DEPRESSION IN HIPPOCAMPAL INTERNEURONS
    JULIE KAUER; Fiscal Year: 1999
    ..The interneurons feed forward and feed back to inhibit both the cell body and dendrites of the excitatory pyramidal cells. Each interneuron synapses onto over one hundred pyramidal cells, and excitation or inhibition of small ..
  70. Glycine Channels and Hippocampal Excitability
    Lori McMahon; Fiscal Year: 2006
    ..of GlyRs provides an undescribed, fundamental inhibitory mechanism that depresses the activity of excitatory pyramidal cells and inhibitory interneurons via direct activation of post-synaptic receptors and furthermore, that GlyR ..
  71. Morphology of Hippocampal Neurons in Depression
    Gorazd Rosoklija; Fiscal Year: 2009
    ..In laboratory animals, stress and glucocorticoids have been shown to result in atrophy of pyramidal cells in hippocampal region CA3...
  72. Computational analysis of genesis of ERP and ERF
    Shingo Murakami; Fiscal Year: 2006
    ..Our models will consist of the pyramidal cells in layers II/III and layer V, the spiny stellate cells in layer IIV and the inhibitory neurons (aspiny ..
  73. HIPPOCAMPAL BENZODIAZEPINE TOLERANCE
    ELIZABETH TIETZ; Fiscal Year: 2004
    ..the appearance of functional tolerance, commonly-held to be mediated by changes at the post-synaptic on CA1 pyramidal cells in the in vitro hippocampus...