neurites

Summary

Summary: In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.

Top Publications

  1. ncbi Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images
    E Meijering
    Department of Medical Informatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Cytometry A 58:167-76. 2004
  2. pmc Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2
    David Ramonet
    Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS ONE 6:e18568. 2011
  3. ncbi Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
    M S Chen
    Brain Research Institute, Department of Neuromorphology, University of Zurich, Switzerland
    Nature 403:434-9. 2000
  4. ncbi Signaling pathways for PC12 cell differentiation: making the right connections
    D Vaudry
    Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892, USA
    Science 296:1648-9. 2002
  5. pmc DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina
    Peter G Fuerst
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Neuron 64:484-97. 2009
  6. pmc Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    K Stamer
    Max Planck Unit for Structural Molecular Biology, 22607 Hamburg, Germany
    J Cell Biol 156:1051-63. 2002
  7. doi Involvement of Akt in neurite outgrowth
    Danielle E Read
    Cell Death and Survival Group, Department of Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland
    Cell Mol Life Sci 66:2975-84. 2009
  8. pmc KLF family members regulate intrinsic axon regeneration ability
    Darcie L Moore
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Science 326:298-301. 2009
  9. pmc Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
    R Brandt
    Institute of Neurobiology, University of Heidelberg, Germany
    J Cell Biol 131:1327-40. 1995
  10. ncbi Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism
    Harald Neumann
    Departments of Neuroimmunology and Neurobiochemistry, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 22:854-62. 2002

Research Grants

  1. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
  2. Neurotoxicity of Magnetic Nanoparticles
    Veronica Shubayev; Fiscal Year: 2010
  3. Regulation of SMN and Identification of its Downstream Target
    Judith Jebanathirajah Steen; Fiscal Year: 2013
  4. Biomimetic scaffolds for targeted peripheral nerve regeneration
    DAVID SHREIBER; Fiscal Year: 2009
  5. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2012
  6. Role of cofilin pathology in mouse models of cognitive impairment
    James R Bamburg; Fiscal Year: 2013
  7. The Role of Cytoplasmic Dynein in Axonal Transport
    KEVIN K PFISTER; Fiscal Year: 2011
  8. Eph/Ephrin signaling in Taste Nerve Targeting
    MICHAEL WILLIAM ROCHLIN; Fiscal Year: 2010
  9. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2012
  10. Novel Gene Targets for CNS Axonal Regeneration
    Vance P Lemmon; Fiscal Year: 2012

Detail Information

Publications340 found, 100 shown here

  1. ncbi Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images
    E Meijering
    Department of Medical Informatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Cytometry A 58:167-76. 2004
    ..To facilitate this task, we developed a semiautomatic neurite tracing technique. This article describes the design and validation of the technique...
  2. pmc Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2
    David Ramonet
    Brain Mind Institute, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland
    PLoS ONE 6:e18568. 2011
    ..These new LRRK2 transgenic mice will provide important tools for understanding the mechanism(s) through which familial mutations precipitate neuronal degeneration and PD...
  3. ncbi Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1
    M S Chen
    Brain Research Institute, Department of Neuromorphology, University of Zurich, Switzerland
    Nature 403:434-9. 2000
    ..Antibodies against Nogo-A stain CNS myelin and oligodendrocytes and allow dorsal root ganglion neurites to grow on CNS myelin and into optic nerve explants...
  4. ncbi Signaling pathways for PC12 cell differentiation: making the right connections
    D Vaudry
    Section on Molecular Neuroscience, Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, MD 20892, USA
    Science 296:1648-9. 2002
    ..The Connections Map for PC12 Cell Differentiation brings into focus the complex array of specific cellular responses that rely on canonical signal transduction systems...
  5. pmc DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina
    Peter G Fuerst
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Neuron 64:484-97. 2009
    ..Therefore, DSCAM and DSCAML1 function similarly in self-avoidance, and are not essential for synaptic specificity in the mouse retina...
  6. pmc Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
    K Stamer
    Max Planck Unit for Structural Molecular Biology, 22607 Hamburg, Germany
    J Cell Biol 156:1051-63. 2002
    ..Tau inhibits kinesin-dependent transport of peroxisomes, neurofilaments, and Golgi-derived vesicles into neurites. Loss of peroxisomes makes cells vulnerable to oxidative stress and leads to degeneration...
  7. doi Involvement of Akt in neurite outgrowth
    Danielle E Read
    Cell Death and Survival Group, Department of Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland
    Cell Mol Life Sci 66:2975-84. 2009
    ..This review will unite and discuss the research to date that has examined the functionality of Akt in neuronal differentiation during development and neurite outgrowth...
  8. pmc KLF family members regulate intrinsic axon regeneration ability
    Darcie L Moore
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Science 326:298-301. 2009
    ..Thus, coordinated activities of different KLFs regulate the regenerative capacity of CNS neurons...
  9. pmc Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
    R Brandt
    Institute of Neurobiology, University of Heidelberg, Germany
    J Cell Biol 131:1327-40. 1995
    ..Our data suggest that tau's amino-terminal projection domain has an important role in neuritic development and establishes tau as a mediator of microtubule-plasma membrane interactions...
  10. ncbi Tumor necrosis factor inhibits neurite outgrowth and branching of hippocampal neurons by a rho-dependent mechanism
    Harald Neumann
    Departments of Neuroimmunology and Neurobiochemistry, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany
    J Neurosci 22:854-62. 2002
    ..We now provide evidence that TNF affects the formation of neurites. Neurons cultured on astrocytic glial cells exhibited reduced outgrowth and branching of neurites after addition ..
  11. ncbi Transport of autophagosomes in neurites of PC12 cells during serum deprivation
    Yi Yang
    Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, P R China
    Autophagy 4:243-5. 2008
    ..The induction of autophagy has been detected in degenerating neurites initiated by different experimental paradigms and hence is of major interest...
  12. pmc Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells
    Edward D Plowey
    Department of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261, USA
    J Neurochem 105:1048-56. 2008
    ..These results indicate an active role for autophagy in neurite remodeling induced by pathogenic mutation of LRRK2...
  13. ncbi Centrosome localization determines neuronal polarity
    Froylan Calderon de Anda
    Cavalieri Ottolenghi Scientific Institute, Universita degli Studi di Torino, 10043 Orbassano, Torino, Italy
    Nature 436:704-8. 2005
    ..in vitro, axon formation follows the segregation of growth-promoting activities to only one of the multiple neurites that form after mitosis...
  14. doi Neuroprotective and axon growth-promoting effects following inflammatory stimulation on mature retinal ganglion cells in mice depend on ciliary neurotrophic factor and leukemia inhibitory factor
    Marco Leibinger
    Department of Experimental Neurology, University of Ulm, 89081 Ulm, Germany
    J Neurosci 29:14334-41. 2009
    ..These data confirm a key role for CNTF in directly mediating the neuroprotective and axon regenerative effects of inflammatory stimulation in the eye and identify LIF as an additional contributing factor...
  15. ncbi Overexpression of the neural growth-associated protein GAP-43 induces nerve sprouting in the adult nervous system of transgenic mice
    L Aigner
    Friedrich Miescher Institute, Basel, Switzerland
    Cell 83:269-78. 1995
    ..A mutant GAP-43 that cannot be phosphorylated by PKC had reduced sprout-promoting activity. The results establish GAP-43 as an intrinsic presynaptic determinant for neurite outgrowth and plasticity...
  16. ncbi Protein kinase C and the regulation of the actin cytoskeleton
    Christer Larsson
    Lund University, Dept of Laboratory Medicine, Molecular Medicine, Entrance 78, 3rd Floor, UMAS SE 205 02, Malmo University Hospital, Malmo, Sweden
    Cell Signal 18:276-84. 2006
    ..Their potential role in PKC effects on the cytoskeleton is discussed...
  17. doi PirB is a functional receptor for myelin inhibitors of axonal regeneration
    Jasvinder K Atwal
    Neurodegeneration Labs and Research Drug Discovery, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
    Science 322:967-70. 2008
    ....
  18. pmc Arp2/3 complex is important for filopodia formation, growth cone motility, and neuritogenesis in neuronal cells
    Farida Korobova
    Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Biol Cell 19:1561-74. 2008
    ..Additionally, Arp2/3 complex depletion led to formation of multiple neurites, erratic pattern of neurite extension, and excessive formation of stress fibers and focal adhesions...
  19. doi An alternatively spliced form of glycogen synthase kinase-3beta is targeted to growing neurites and growth cones
    Alison Wood-Kaczmar
    The MRC Centre for Developmental Neurobiology, New Hunts House, Guy s Campus, King s College London, London SE1 1UL, UK
    Mol Cell Neurosci 42:184-94. 2009
    ..sub-cellular fractionation of neonatal rat brain showed that GSK-3beta2 is present in fractions enriched in neurites and growth cones...
  20. doi Axon formation in neocortical neurons depends on stage-specific regulation of microtubule stability by the dual leucine zipper kinase-c-Jun N-terminal kinase pathway
    Syu ichi Hirai
    Department of Molecular Biology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 31:6468-80. 2011
    ..Together, these in vivo and in vitro observations indicate that the DLK-JNK pathway facilitates axon formation in neocortical neurons via stage-specific regulation of microtubule stability...
  21. ncbi Fas engagement induces neurite growth through ERK activation and p35 upregulation
    Julie Desbarats
    Department of Physiology, McGill University, Montreal, Quebec, Canada, H3G 1Y6
    Nat Cell Biol 5:118-25. 2003
    ..Our findings define a role for Fas as an inducer of both neurite growth in vitro and accelerated recovery after nerve injury in vivo...
  22. doi Simple Neurite Tracer: open source software for reconstruction, visualization and analysis of neuronal processes
    Mark H Longair
    Institute of Neuroinformatics, Uni ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Bioinformatics 27:2453-4. 2011
    ..We present an application for semi-automated tracing of neurons to quickly annotate noisy datasets and construct complex neuronal topologies, which we call the Simple Neurite Tracer...
  23. ncbi The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI
    Toshihide Yamashita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nat Neurosci 6:461-7. 2003
    ..This peptide has potential as a therapeutic agent against the inhibitory cues that block regeneration in the central nervous system...
  24. ncbi The familial Parkinsonism gene LRRK2 regulates neurite process morphology
    David Macleod
    Departments of Pathology and Neurology, Center for Neurobiology and Behavior and Taub Institute, Columbia University, College of Physicians and Surgeons 15 403, 630 West 168th Street, New York, New York 10032, USA
    Neuron 52:587-93. 2006
    ..Neurons that express PD-associated LRRK2 mutations additionally harbor prominent phospho-tau-positive inclusions with lysosomal characteristics and ultimately undergo apoptosis...
  25. ncbi The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth
    Soline Estrach
    CRBM CNRS, UPR 1086 CNRS, 1919 Route de Mende, 34293 5, Montpellier Cedex, France
    Curr Biol 12:307-12. 2002
    ..In addition, we show that Trio protein accumulates under NGF stimulation. Thus, Trio is the first identified Rho-GEF involved in the NGF-differentiation signaling...
  26. pmc miR-375 inhibits differentiation of neurites by lowering HuD levels
    Kotb Abdelmohsen
    Laboratory of Cellular and Molecular Biology, National Institute on Aging Intramural Research Program, NIH, Baltimore, MD 21224, USA
    Mol Cell Biol 30:4197-210. 2010
    ..Our findings indicate that miR-375 modulates neuronal HuD expression and function, in turn affecting dendrite abundance...
  27. ncbi Neuro tissue engineering of glial nerve guides and the impact of different cell types
    Martin Lietz
    NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Markwiesenstr 55, D 72770 Reutlingen, Germany
    Biomaterials 27:1425-36. 2006
    ..In summary, for more rapid regrowth, functional boB can be induced by guided microtissue engineering. By considering both the negative and positive effects of cell interactions, a more rational design of nerve implants becomes feasible...
  28. pmc The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho
    Toshihide Yamashita
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Biol 157:565-70. 2002
    ..Ganglioside GT1b, which is one of the binding partners of MAG, specifically associates with p75(NTR). Thus, p75(NTR) and GT1b may form a receptor complex for MAG to transmit the inhibitory signals in neurons...
  29. pmc Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons
    Jonathan Gilley
    The Babraham Institute, Babraham Research Campus, Cambridge, UK
    PLoS Biol 8:e1000300. 2010
    ..Nmnat2 is by far the most labile Nmnat isoform and is depleted in distal stumps of injured neurites before Wallerian degeneration begins...
  30. doi A novel developmental role for kisspeptin in the growth of gonadotrophin-releasing hormone neurites to the median eminence in the mouse
    Z Fiorini
    Centre for Neuroendocrinology, Department of Anatomy and Structural Biology, University of Otago School of Medical Sciences, Dunedin, New Zealand
    J Neuroendocrinol 22:1113-25. 2010
    ..in neurite growth in other neurones, we investigated whether KISS1 may play a role in the normal growth of GnRH neurites to the median eminence...
  31. ncbi NeuriteTracer: a novel ImageJ plugin for automated quantification of neurite outgrowth
    Madeline Pool
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, BT 109, 3801 rue University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci Methods 168:134-9. 2008
    ..The plugin analyzes fluorescence microscopy images of neurites and nuclei of dissociated cultured neurons...
  32. pmc Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function
    Ryota L Matsuoka
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 71:460-73. 2011
    In the vertebrate retina, neurites from distinct neuronal cell types are constrained within the plexiform layers, allowing for establishment of retinal lamination...
  33. ncbi LKB1/STRAD promotes axon initiation during neuronal polarization
    Maya Shelly
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA
    Cell 129:565-77. 2007
    ..Thus local LKB1/STRAD accumulation and PKA-dependent LKB1 phosphorylation represents an early signal for axon initiation...
  34. pmc A novel null allele of mouse DSCAM survives to adulthood on an inbred C3H background with reduced phenotypic variability
    Peter G Fuerst
    The Jackson Laboratory, Bar Harbor, Maine, USA
    Genesis 48:578-84. 2010
    ..These results indicate that, in the retina, additional DSCAM-dependent processes can be found by analysis of mutations on different genetic backgrounds...
  35. pmc Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis
    Stephanie L Gupton
    The Koch Institute for Integrative Cancer Research at MIT, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Dev Cell 18:725-36. 2010
    Neurons establish their unique morphology by elaborating multiple neurites that subsequently form axons and dendrites. Neurite initiation entails significant surface area expansion, necessitating addition to the plasma membrane...
  36. pmc Automated tracing of neurites from light microscopy stacks of images
    Paarth Chothani
    Department of Physics and Center for Interdisciplinary Research on Complex Systems, Northeastern University, Boston, MA 02115, USA
    Neuroinformatics 9:263-78. 2011
    ..We show how the minimal error-rate of an ideal reconstruction procedure depends on the density of labeled neurites, giving rise to the fundamental limitation of an LM based approach for neural circuit research...
  37. ncbi The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor
    Margaret Fahnestock
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada
    J Neurochem 89:581-92. 2004
    ..These data, coupled with our previous report that proNGF is the major form of NGF in the CNS, suggest that proNGF could be responsible for much of the biological activity normally attributed to mature NGF in vivo...
  38. pmc Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways
    Tomoko Nishimura
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan
    PLoS ONE 3:e2558. 2008
    ..In this study, we examined the roles of cellular signaling pathways in the potentiation of NGF-induced neurite outgrowth by fluvoxamine and sigma-1 receptor agonists...
  39. ncbi Neurites undergoing Wallerian degeneration show an apoptotic-like process with Annexin V positive staining and loss of mitochondrial membrane potential
    Caroline Sievers
    Center for Molecular Medicine ZMMK and Institute for Genetics, University of Cologne, Germany
    Neurosci Res 46:161-9. 2003
    ..We studied Wallerian degeneration in dorsal root ganglion (DRG) explants in culture by separating neurites from their cell bodies with a scalpel...
  40. ncbi Assessment of PC12 cell differentiation and neurite growth: a comparison of morphological and neurochemical measures
    Kaberi P Das
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neurotoxicol Teratol 26:397-406. 2004
    ..However, ET-18 did not alter the expression of GAP-43 or synapsin I. These data suggest that GAP-43 may be a useful indicator of the status of PC12 cell differentiation...
  41. ncbi Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    M Difiglia
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:1990-3. 1997
    ..fragment of mutant huntingtin was localized to neuronal intranuclear inclusions (NIIs) and dystrophic neurites (DNs) in the HD cortex and striatum, which are affected in HD, and polyglutamine length influenced the extent of ..
  42. pmc Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina
    Ryota L Matsuoka
    The Solomon H Snyder Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 470:259-63. 2011
    ..Therefore, neuronal targeting to subdivisions of the IPL in the mammalian retina is directed by repulsive transmembrane guidance cues present on neuronal processes...
  43. ncbi NF-kappaB signalling regulates the growth of neural processes in the developing PNS and CNS
    Humberto Gutierrez
    School of Biosciences, Biomedical Building, Museum Avenue, PO Box 911, Cardiff, CF10 3US, Wales
    Development 132:1713-26. 2005
    ..This function of NF-kappaB has important implications for neural development and may provide an explanation for reported involvement of NF-kappaB in learning and memory...
  44. ncbi Regulation of intrinsic neuronal properties for axon growth and regeneration
    Ferdinando Rossi
    Rita Levi Montalcini Centre for Brain Repair, Department of Neuroscience, University of Turin, Corso Raffaello 30, I 10125 Turin, Italy
    Prog Neurobiol 81:1-28. 2007
    ..by the activity of specific molecular sets, which sense environmental signals and sustain structural extension of neurites. The expression and function of these molecules are dynamically regulated by multiple mechanisms, which adjust ..
  45. pmc Neurite outgrowth involves adenomatous polyposis coli protein and beta-catenin
    Violet Votin
    Department of Biological Sciences, Stanford University, Beckman Center B121, Stanford, CA 94305, USA
    J Cell Sci 118:5699-708. 2005
    Neuronal morphogenesis involves the initial formation of neurites and then differentiation of neurites into axons and dendrites. The mechanisms underlying neurite formation are poorly understood...
  46. ncbi Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement
    N Sousa
    Department of Anatomy, Porto Medical School, Alameda Prof Hernani Monteiro, 4200 319, Porto, Portugal
    Neuroscience 97:253-66. 2000
    ..We conclude that there is an intimate relationship between corticosteroid levels, hippocampal neuritic structure and hippocampal-dependent learning and memory...
  47. ncbi Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells
    Kazuhiro Aoki
    Department of Tumor Virology, Research Institute for Microbial Diseases, Osaka University, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    J Biol Chem 279:713-9. 2004
    ..It was concluded that the localized activation of Rac1 and Cdc42 was caused by both guanine nucleotide exchange factors and GAPs, and was important for neurite extension...
  48. doi Developmental neurotoxicity testing in vitro: models for assessing chemical effects on neurite outgrowth
    Nicholas M Radio
    Neurotoxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protections Agency USEPA, B105 06 Research Triangle Park, NC 27711, USA
    Neurotoxicology 29:361-76. 2008
    ....
  49. ncbi A change in the selective translocation of the Kinesin-1 motor domain marks the initial specification of the axon
    Catherine Jacobson
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, Oregon 97239, USA
    Neuron 49:797-804. 2006
    ..Throughout development, truncated Kinesin-3 accumulates at the tips of all neurites. In contrast, Kinesin-1 selectively accumulates in only a subset of neurites...
  50. pmc NeuronMetrics: software for semi-automated processing of cultured neuron images
    Martha L Narro
    ARL Division of Neurobiology, University of Arizona, Tucson, AZ 85721, USA
    Brain Res 1138:57-75. 2007
    ..It skeletonizes the neuron image using two complementary image-processing techniques, capturing fine terminal neurites with high fidelity. An algorithm was devised to span wide gaps in the skeleton...
  51. ncbi Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth
    L R Zukerberg
    Howard Hughes Medical Institute, Department of Pathology, Massachusetts General Hospital, Boston 02114, USA
    Neuron 26:633-46. 2000
    ..Furthermore, expression of active Abl resulted in lengthening of neurites. The data provide evidence for a Cables-mediated interplay between the Cdk5 and c-Abl signaling pathways in the ..
  52. ncbi Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo
    Paul Lingor
    Department of Neurology, Georg August University Gottingen, Faculty of Medicine, Gottingen, Germany
    J Neurochem 103:181-9. 2007
    ..The selection of a suitable inhibitor with a broad therapeutic window, however, is crucial in order to minimize unwanted side effects and to avoid deleterious effects on nerve fiber growth...
  53. ncbi cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1)
    E K Stachowiak
    Molecular and Structural Neurobiology and Gene Therapy Program, Department Pathology and Anatomical Sciences, State University of New York, Buffalo 14214, USA
    J Neurochem 84:1296-312. 2003
    ..dB-cAMP induced nuclear accumulation of FGFR1 and caused neuronal differentiation, accompanied by outgrowth of neurites expressing MAP2 and neuron-specific neurofilament-L protein and enolase...
  54. doi ADNP differential nucleus/cytoplasm localization in neurons suggests multiple roles in neuronal differentiation and maintenance
    Shmuel Mandel
    Department of Human Molecular Genetics and Biochemistry, Sackler Medical School, Tel Aviv University, Tel Aviv, 69978, Israel
    J Mol Neurosci 35:127-41. 2008
    ..ADNP-like immunohistochemical localization to the neuronal cytoplasm and neurites was shown in this study not only in the cellular model but also in the brain cerebral cortex and olfactory bulb...
  55. doi Rapid differentiation of human embryonal carcinoma stem cells (NT2) into neurons for neurite outgrowth analysis
    Million Adane Tegenge
    Division of Cell Biology, Institute of Physiology, University of Veterinary Medicine Hannover, Bischofsholer Damm 15, 30173, Hannover, Germany
    Cell Mol Neurobiol 31:635-43. 2011
    ....
  56. pmc Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease
    Melanie Meyer-Luehmann
    Alzheimer s Disease Research Laboratory, Department of Neurology, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Nature 451:720-4. 2008
    ..Progressive neuritic changes ensue, leading to increasingly dysmorphic neurites over the next days to weeks. These data establish plaques as a critical mediator of neuritic pathology.
  57. pmc Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
    Barry Boland
    Center for Dementia Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    J Neurosci 28:6926-37. 2008
    ..double-membrane-limited AVs, containing cathepsin D and incompletely degraded LC3-II in perikarya and neurites. Similar structures accumulated in large numbers when fusion of autophagosomes with lysosomes was slowed by ..
  58. pmc NeuriteQuant: an open source toolkit for high content screens of neuronal morphogenesis
    Leif Dehmelt
    Max Planck Institute of Molecular Physiology, Otto Hahn Str, 11, 44227 Dortmund, Germany
    BMC Neurosci 12:100. 2011
    ..Efficient analytical strategies are required to enable rapid, reliable, quantitative analysis of neuronal morphology in these valuable model systems...
  59. doi MARCKS dephosphorylation is involved in bradykinin-induced neurite outgrowth in neuroblastoma SH-SY5Y cells
    Atsuhiro Tanabe
    Laboratory of Pharmacology, School of Pharmacy, Kitasato University, Minato ku, Tokyo, Japan
    J Cell Physiol 227:618-29. 2012
    ..Thus these findings show a novel BK signal cascade-that is, BK promotes neurite outgrowth through transient MARCKS phosphorylation involving the PKC-dependent RhoA/ROCK pathway and PP2A in a neuroblastoma cell line...
  60. pmc WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
    Jo Ann V Antenor-Dorsey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Neurodegener 7:5. 2012
    ..Here, we used dissociated dopaminergic cultures to test the hypothesis that catalytically active Nmnat1 protects dopaminergic neurons from toxin-mediated axonal injury...
  61. ncbi An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth
    Dagmar Pommereit
    European Neuroscience Institute Göttingen, Cell Biophysics Group and DFG Research Center for Molecular Physiology of the Brain CMPB, D 37073 Gottingen, Germany
    J Cell Sci 120:2694-705. 2007
    ..The functional uncoupling between both pathways represents a novel regulatory mechanism that enables switching between morphologically distinct - Cdc42- or TC10-dominated - forms of cellular membrane outgrowth...
  62. pmc Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors
    Raheleh Masoudi
    Department of Biology, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    J Biol Chem 284:18424-33. 2009
    ..We conclude that the relative level of proNGF receptors determines whether this precursor exhibits neurotrophic or apoptotic activity...
  63. pmc Synaptic functions of invertebrate varicosities: what molecular mechanisms lie beneath
    Carlo Natale Giuseppe Giachello
    Department of Neuroscience, University of Torino, Corso Raffaello 30, 10125 Torino, Italy
    Neural Plast 2012:670821. 2012
    ..In particular, the role of invertebrate synapsin in the formation of presynaptic terminals and the cell-to-cell interactions that induce specific structural and functional changes in their respective targets will be analyzed...
  64. ncbi Neural tissue engineering: a self-organizing collagen guidance conduit
    James B Phillips
    University College London, Tissue Repair and Engineering Centre, Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
    Tissue Eng 11:1611-7. 2005
    ..Neural regeneration through this device was significantly greater than in controls, demonstrating that this system has potential both as a simple robust clinical implant and as a three-dimensional engineered tissue model...
  65. pmc Rodents rely on Merkel cells for texture discrimination tasks
    Stephen M Maricich
    Department of Pediatrics and Departments of Dermatology, Neurosciences, and Otolaryngology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Neurosci 32:3296-300. 2012
    ..These findings suggest that Merkel cell/neurite complexes are essential for texture discrimination tasks involving glabrous skin but not whiskers...
  66. doi Signaling mechanisms of neurite outgrowth induced by the cell adhesion molecules NCAM and N-cadherin
    S M Hansen
    ENKAM Pharmaceuticals A S, Fruebjergvej 3, Copenhagen Ø, 2100 Denmark
    Cell Mol Life Sci 65:3809-21. 2008
    ..In particular, we will focus on direct interaction between NCAM and N-cadherin with a number of intracellular partners, as well as on their interaction with the fibroblast growth factor receptor (FGFR)...
  67. doi Mevastatin-induced neurite outgrowth of neuroblastoma cells via activation of EGFR
    M E Evangelopoulos
    Department of Neurology, Eginitio Hospital, University of Athens, Athens, Greece
    J Neurosci Res 87:2138-44. 2009
    ....
  68. ncbi Molecular characterization of the effects of Y-27632
    Hassina Darenfed
    Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec, Canada
    Cell Motil Cytoskeleton 64:97-109. 2007
    ..We conclude that several kinases contribute to the global effect of Y-27632 on cellular responses...
  69. ncbi Pyk2 and FAK regulate neurite outgrowth induced by growth factors and integrins
    I Ivankovic-Dikic
    Ludwig Institute for Cancer Research, Box 595, Husargatan 3, Uppsala, S 75124, Sweden
    Nat Cell Biol 2:574-81. 2000
    ..of growth-factor receptors and integrins activates the focal-adhesion kinase (FAK) family to promote outgrowth of neurites in PC12 and SH-SY5Y cells...
  70. doi Voltage-gated Na+ channel beta1 subunit-mediated neurite outgrowth requires Fyn kinase and contributes to postnatal CNS development in vivo
    William J Brackenbury
    Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 0632, USA
    J Neurosci 28:3246-56. 2008
    ..We conclude that voltage-gated Na(+) channel beta1 subunits signal via multiple pathways on multiple timescales and play important roles in the postnatal development of the CNS...
  71. doi Integrin-laminin interactions controlling neurite outgrowth from adult DRG neurons in vitro
    Stefan Plantman
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Mol Cell Neurosci 39:50-62. 2008
    ....
  72. pmc Brain-derived neurotrophic factor attracts geniculate ganglion neurites during embryonic targeting
    Natalia Hoshino
    Biology Department, Loyola University Chicago, Chicago, IL 60660, USA
    Dev Neurosci 32:184-96. 2010
    ..Further, neurites advanced faster toward the BDNF bead than away from it, even if the average amount of neurotrophic factor ..
  73. pmc DCX, a new mediator of the JNK pathway
    Amos Gdalyahu
    Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot, Israel
    EMBO J 23:823-32. 2004
    ....
  74. ncbi Cooperative modulation of neuritogenesis by PC12 cells by topography and nerve growth factor
    John D Foley
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, Wisconsin 53706, USA
    Biomaterials 26:3639-44. 2005
    ..Contact guidance of neurites by topographic features is well known, but the role that topography plays in the modulation of neuritogenesis has ..
  75. ncbi Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice
    Yona Goldshmit
    Center for Neuroscience and School of Physiotherapy, University of Melbourne, Melbourne, Victoria 3010, Australia
    J Neurosci 24:10064-73. 2004
    ..Neurons grown on wild-type astrocytes extended shorter neurites than on EphA4-/- astrocytes, but longer neurites when the astrocyte EphA4 was blocked by monomeric EphrinA5-Fc...
  76. pmc Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis
    Philipp Niethammer
    Zentrum für Molekulare Neurobiologie, Universitat Hamburg, D 20246 Hamburg, Germany
    J Cell Biol 157:521-32. 2002
    ..Likewise, NCAM-triggered neurite outgrowth is also completely blocked by a specific FGF receptor inhibitor, indicating that cosignaling via raft-associated kinases and FGF receptor is essential for neuritogenesis...
  77. ncbi Lysophosphatidylethanolamine in Grifola frondosa as a neurotrophic activator via activation of MAPK
    Atsuyoshi Nishina
    Gunma Industrial Technology Center, 884 1 Kamesato, Maebashi, Gunma 379 2147, Japan
    J Lipid Res 47:1434-43. 2006
    ..This study has clarified for the first time the involvement of the MAPK signal cascade in LPE actions...
  78. doi Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals
    Toshiro Kanazawa
    Laboratory of Strucutural Neuropathology, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
    Brain Pathol 22:67-78. 2012
    Progressive aggregation of α-synuclein (αS) from pale bodies (PBs) and extension from Lewy neurites (LNs) are candidate mechanisms for Lewy body (LB) formation...
  79. pmc Rho GTPase regulation of α-synuclein and VMAT2: implications for pathogenesis of Parkinson's disease
    Zhigang Zhou
    Department of Neurology, University of Michigan and VA Ann Arbor Healthcare System, 5031 BSRB, Ann Arbor, MI 48109, USA
    Mol Cell Neurosci 48:29-37. 2011
    Accumulation of α-synuclein (Asyn) in neuronal perikarya and dystrophic neurites is characteristic of idiopathic and familial Parkinson's disease...
  80. ncbi Synapse formation in the absence of cell bodies requires protein synthesis
    Samuel Schacher
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 22:1831-9. 2002
    ..These results support the idea that distal neuritic processes contain stable mRNAs and the macromolecular machinery for protein synthesis that are required for the formation of new synaptic connections...
  81. ncbi Gadd45a, the gene induced by the mood stabilizer valproic acid, regulates neurite outgrowth through JNK and the substrate paxillin in N1E-115 neuroblastoma cells
    Junji Yamauchi
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Oukura, Setagaya, Tokyo 157 8535, Japan
    Exp Cell Res 313:1886-96. 2007
    ..Taken together, these results suggest that upregulation of Gadd45a explains one of the mechanisms whereby VPA induces the neurotrophic effect, providing a new role of Gadd45a in neurite outgrowth...
  82. pmc Phospholipase Cdelta3 regulates RhoA/Rho kinase signaling and neurite outgrowth
    Zen Kouchi
    Laboratory of Genome and Biosignal, Tokyo University of Pharmacy and Life Sciences, 1432 1 Horinouchi, Hachioji, 192 0392 Tokyo, Japan
    J Biol Chem 286:8459-71. 2011
    ..These results indicate that PLCδ3 negatively regulates RhoA expression, inhibits RhoA/Rho kinase signaling, and thereby promotes neurite extension...
  83. pmc Neurotrophic effect of citrus 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: promotion of neurite outgrowth via cAMP/PKA/CREB pathway in PC12 cells
    Hui Chi Lai
    Department of Molecular Biology and Human Genetics, Tzu Chi University, Hualien, Taiwan
    PLoS ONE 6:e28280. 2011
    ..A PKC-dependent and CREB-independent pathway was also involved in its neurotrophic action...
  84. pmc Robust discrimination between self and non-self neurites requires thousands of Dscam1 isoforms
    Daisuke Hattori
    Department of Biological Chemistry, Howard Hughes Medical Institute, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095, USA
    Nature 461:644-8. 2009
    ..We conclude that thousands of isoforms are essential to provide neurons with a robust discrimination mechanism to distinguish between self and non-self during self-avoidance...
  85. ncbi Electrospinning of nano/micro scale poly(L-lactic acid) aligned fibers and their potential in neural tissue engineering
    F Yang
    Department of Mechanical Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576
    Biomaterials 26:2603-10. 2005
    ..Based on the experimental results, the aligned nanofibrous PLLA scaffold could be used as a potential cell carrier in neural tissue engineering...
  86. pmc PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity
    David Ramonet
    Laboratory of Molecular Neurodegenerative Research, School of Life Sciences, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Hum Mol Genet 21:1725-43. 2012
    ..Collectively, this study reveals a number of intriguing neuronal phenotypes due to the loss- or gain-of-function of ATP13A2 that support a role for this protein in regulating intracellular cation homeostasis and neuronal integrity...
  87. ncbi TACE-induced cleavage of NgR and p75NTR in dorsal root ganglion cultures disinhibits outgrowth and promotes branching of neurites in the presence of inhibitory CNS myelin
    Zubair Ahmed
    Molecular Neuroscience Group, Division of Medical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    FASEB J 20:1939-41. 2006
    ..Thus, TACE-induced cleavage of NgR and RIP of p75(NTR) abrogates axon growth inhibitory signaling, thereby disinhibiting CNS axon/neurite growth...
  88. ncbi Phenotypic and functional characteristics of mesenchymal stem cells differentiated along a Schwann cell lineage
    Jenny Caddick
    Blond McIndoe Research Laboratories, University of Manchester, Manchester, United Kingdom
    Glia 54:840-9. 2006
    ..These findings support the assertion that MSCs can be differentiated into cells that are Schwann cell-like in terms of both phenotype and function...
  89. pmc The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway
    Yvona Ward
    Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    J Cell Biol 157:291-302. 2002
    ..In addition, Gem reverted the anchorage-independent growth and invasiveness of Dbl-transformed fibroblasts. These results identify physiological roles for Gem and Rad in cytoskeletal regulation mediated by ROK...
  90. pmc Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival
    Hisatsugu Koshimizu
    National Institute of Advanced Industrial Science and Technology AIST, Ikeda, 563 8577 Japan
    Mol Brain 2:27. 2009
    ....
  91. ncbi RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo
    Hironori Katoh
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Nature 424:461-4. 2003
    ..We conclude that RhoG activates Rac1 through Elmo and Dock180 to control cell morphology...
  92. ncbi Blockade of NGF-induced neurite outgrowth by a dominant-negative inhibitor of the egr family of transcription regulatory factors
    Y Levkovitz
    Departments of Neuroscience, Psychiatry, and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 21:45-52. 2001
    ..Thus, we conclude (1) that induction of Egr family members and activation of the MEK/ERK pathway by NGF are mediated by separate signaling pathways and (2) that both are required to trigger neurite outgrowth induced by NGF...
  93. pmc A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration
    Lynn C Usher
    Departments of Pharmacology, Neurological Surgery, and Ophthalmology, and Miami Project to Cure Paralysis, Neuroscience Program, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    J Neurosci 30:4693-706. 2010
    ..These compounds should provide insight into the mechanisms through which glial-derived inhibitors of regeneration act, and could lead to the development of novel therapies for CNS injury...
  94. pmc Automatic robust neurite detection and morphological analysis of neuronal cell cultures in high-content screening
    Chaohong Wu
    Department of Computer Science, Brandeis University, Waltham, MA 02454, USA
    Neuroinformatics 8:83-100. 2010
    ..adaptive histogram equalization method; segment neuromeres using Gabor-wavelet texture analysis; and detect faint neurites by a novel phase-based neurite extraction algorithm that is invariant to changes in illumination and contrast and ..
  95. ncbi IL-1beta promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway
    Ko Temporin
    Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 365:375-80. 2008
    ..These findings suggest that IL-1beta may contribute to nerve regeneration by promoting neurite outgrowth following nerve injury...
  96. ncbi Selective regulation of neurite extension and synapse formation by the beta but not the alpha isoform of CaMKII
    Charles C Fink
    Department of Molecular Pharmacology, Stanford University Medical School, Stanford, CA 94305, USA
    Neuron 39:283-97. 2003
    ..These results show that the two main neuronal CaMKII isoforms have markedly different roles in neuronal plasticity, with CaMKIIalpha regulating synaptic strength and CaMKIIbeta controlling the dendritic morphology and number of synapses...
  97. doi Micropatterning neural cell cultures in 3D with a multi-layered scaffold
    Anja Kunze
    Microsystems Laboratory LMIS4, Institute of Microengineering Lausanne, Ecole Polytechnique Federale de Lausanne, Station 17, CH 1015 Lausanne, Switzerland
    Biomaterials 32:2088-98. 2011
    ..compatible with optical microscopy, the dynamic process of neural growth can be imaged, and density and number of neurites can be quantified...
  98. ncbi Genetic analysis of Netrin genes in Drosophila: Netrins guide CNS commissural axons and peripheral motor axons
    K J Mitchell
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley California 94720, USA
    Neuron 17:203-15. 1996
    ..Expression of either Netrin gene in all muscles also results in aberrant motor projections. Thus, Drosophila Netrins are required for the guidance of commissural axons at the midline, and of motor axons to their target muscles...
  99. pmc The regulative role of neurite mechanical tension in network development
    Sarit Anava
    Department of Zoology, Tel Aviv University, Tel Aviv, 69978 Israel
    Biophys J 96:1661-70. 2009
    ..to these surfaces were isolated anchoring sites consisting of carbon nanotube islands to which the cells and the neurites could mechanically attach...
  100. ncbi Rapostlin is a novel effector of Rnd2 GTPase inducing neurite branching
    Hirotada Fujita
    Laboratory of Molecular Neurobiology, Graduate School of Biostudies, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    J Biol Chem 277:45428-34. 2002
    ..Therefore, Rapostlin is the first effector of Rnd2, regulating neurite branch formation...
  101. ncbi Estrogen increases sensory nociceptor neuritogenesis in vitro by a direct, nerve growth factor-independent mechanism
    A D Blacklock
    Department of Molecular and Integrative Physiology, Kansas University Medical Center, Kansas City, KS, 66160 7401, USA
    Eur J Neurosci 21:2320-8. 2005
    ..NGF increased neuron size, survival and numbers of neurons with neurites, but did not affect neurite area per neuron...

Research Grants68

  1. Dynamics of Kinesins, Dyneins, and Myosins
    Paul R Selvin; Fiscal Year: 2010
    ..g. PC12 neurites, to see if the kinetics are similar;4) to measure the movement of melanosomes (which are non-fluorescent), using ..
  2. Neurotoxicity of Magnetic Nanoparticles
    Veronica Shubayev; Fiscal Year: 2010
    ..outgrowth in differentiated PC12 cells under magnetic force, we observed MNP-induced de-differentiation, loss of neurites, and cell death with increasing concentration of iron oxide, but not dimercaptosuccinic acid (DMSA) used for MNP ..
  3. Regulation of SMN and Identification of its Downstream Target
    Judith Jebanathirajah Steen; Fiscal Year: 2013
    ..previous studies that SMN may be necessary for the transport, stability and/or translation of certain mRNAs in neurites. These data together prompted us to formulate a working model in which: 1) ubiquitination by APC regulates the ..
  4. Biomimetic scaffolds for targeted peripheral nerve regeneration
    DAVID SHREIBER; Fiscal Year: 2009
    ..We have demonstrated that a soluble mimic of HNK-1 increases the accuracy of regenerating motor neurites into the muscle branch of the femoral nerve and enhances recovery of motor function following peripheral nerve ..
  5. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2012
    ..Both initial formation of growth cone-tipped neurites, and subsequent guided locomotion of axonal growth cones, require F-actin and microtubule (MT) dynamics...
  6. Role of cofilin pathology in mouse models of cognitive impairment
    James R Bamburg; Fiscal Year: 2013
    ..This cofilin oxidation results within neurites in the formation of rod shaped cofilin-saturated actin bundles (rods)...
  7. The Role of Cytoplasmic Dynein in Axonal Transport
    KEVIN K PFISTER; Fiscal Year: 2011
    ..We have shown that both are present in neurites, axons, and dendrites...
  8. Eph/Ephrin signaling in Taste Nerve Targeting
    MICHAEL WILLIAM ROCHLIN; Fiscal Year: 2010
    ..Second, to determine if Eph/ephrin signaling stabilizes or repels taste and somatosensory neurites, ganglion explants will be grown on substrates that have been micro-patterned with alternating stripes of Ephs or ..
  9. NEURAL CONTROL OF GASTROINTESTINAL ACTIVITY
    Michael D Gershon; Fiscal Year: 2012
    ..we will determine whether endogenous 5-HT is essential for survival of enteric neurons, avoiding degeneration of neurites, and recruiting precursors to generate new neurons, whether these actions are 5-HT4-mediated (utilizing 5-HT4null ..
  10. Novel Gene Targets for CNS Axonal Regeneration
    Vance P Lemmon; Fiscal Year: 2012
    ..a well-established in vitro assay where neurons are grown on myelin or proteoglycans and the lengths of their neurites measured...
  11. Role of RanBP9 on dendritic and spine injury in an Alzheimer's mouse model
    MADEPALLI KRISHNAPPA LAKSHMANA; Fiscal Year: 2013
    ..of cognitive deficits in Alzheimer[unreadable]s patients and since RanBP9 is present in substantial amounts in neurites and is a strong inhibitor of neurite outgrowth, we next want to examine in this proposal, whether RanBP9-induced ..
  12. Regulation of kinesin-5 during neuronal development: studies on dendrites
    OLGA IGOREVNA KAHN; Fiscal Year: 2013
    ..is that kinesin-5 acts as a [unreadable]brake[unreadable] to modulate the growth and development of these neurites. Mechanistically, the hypothesis is that kinesin-5 attenuates the growth of axons and dendrites by limiting the ..
  13. Role of neuronal migration genes in synaptogenesis and plasticity
    Anamaria Sudarov; Fiscal Year: 2013
    ..Moreover, Lis1 happloinsufficiency is associated with marked reduction in filopodia formation on neurites of hippocampal and cerebellar neurons...
  14. RGS proteins as novel integrators of G protein and MAPK signaling
    John R Hepler; Fiscal Year: 2013
    ..We find that RGS14 is expressed predominantly in brain, specifically within dendrites/neurites of hippocampal neurons important for learning/memory (i.e. pyramidal cells of the CA1/CA2 region)...
  15. Mechanisms of Hypovitaminosis D Pain: Role of Nociceptor Sprouting.
    SARAH ELIZABETH TAGUE; Fiscal Year: 2010
    ..Neurite outgrowth in adult dissociated DRG cultures will be determined by morphometric analysis of immunoreactive neurites. In addition, neurite chamber cultures (Campenot cultures) will be used to determine whether vitamin D initiates ..
  16. NEUROPATHOLOGY OF CHRONIC MANGANESE EXPOSURE
    Brad A Racette; Fiscal Year: 2010
    ..Distribution of Lewy bodies, Lewy neurites and alpha-synuclein aggregates, if any, will also be evaluated after tissues are stained with an antibody against ..
  17. Localized immobilization of ephrin-B2 for neurite guidance in 3D culture
    Michael J Moore; Fiscal Year: 2010
    ..The overall goal of this project is to develop a 3D tissue culture model to study the guidance of retinal neurites in response to engineered cues that mimic the spatial distribution of ligands found at the optic chiasm during ..
  18. Compartmentation of Neuronal ATP and Metabolic Regulation of Excitability
    Mathew Tantama; Fiscal Year: 2013
    ..ATP compartmentation may occur because of the specialized geometry of neurons whose neurites extend far from the cell body...
  19. analysis of srGAP2 in cortical development in vitro and in vivo
    Jaeda Coutinho-Budd; Fiscal Year: 2012
    ..involves coordinated migration of pyramidal neurons to their final location, as well as subsequent projection of neurites to their targets...
  20. Rho GTPases and Synaptic Morphology: Visualizing the Proteome with FRET Imaging
    Nima Sharifai; Fiscal Year: 2013
    ..aspect of this work will be visualizing how the neuron integrates converging signaling pathways to grow neurites and form synapses...
  21. Mechanisms of mRNA localization to neuronal synapses
    Elliott James Meer; Fiscal Year: 2013
    ..Finally, I will identify the RN binding proteins that localize sensorin mRNA to neurites and synapses and study the dynamics of these proteins during synapse formation...
  22. Pleiotrophin for Neurorestoration in Parkinson's Disease
    SARA ELIZABETH GOMBASH LAMPE; Fiscal Year: 2013
    ..unreadable] -syn rodent models exhibit [unreadable]-syn containing neuron bodies and dystrophic neurites that neurotoxin models fail to recapitulate...
  23. Molecular Mechanisms Underlying Axon Pathfinding
    Wen Cheng Xiong; Fiscal Year: 2012
    ..Myo X also appears to be involved in delivering DCC to the cell periphery or neurites. Thus, the proposed studies are based on the hypothesis that PITPalpha and Myo X are involved in initiating DCC ..
  24. Characterization of an FAD pathogenic PS1 mutation with complete loss of activity
    HANNAH LOUISE BRAUTIGAM; Fiscal Year: 2013
    ..consist of extracellular amyloid plaques, amyloid angiopathy, neurofibrillary tangles, inflammation, dystrophic neurites, and neuronal death...
  25. Roles of reticulon proteins in neurodegenerative diseases
    Riqiang Yan; Fiscal Year: 2013
    ..However, this increased expression of RTN3 also facilitated the formation of RTN3 immunoreactive dystrophic neurites (RIDNs) in the hippocampus, and the occurrence of RIDNs impaired hippocampal synaptic function...
  26. The role of BARHL2 in the mosaic pattering and dendritic tiling of retinal amacri
    Lin Gan; Fiscal Year: 2013
    ..In addition, the neurites from an individual cell display self-avoidance properties...
  27. BIOLOGY OF ALZHEIMER AMYLOID IN NEURONS
    Gunnar K Gouras; Fiscal Year: 2010
    ..of important synaptic receptors, in the ubiquitin proteasome system and/or in retrograde transport within neurites. In addition, we hypothesize that our preliminary evidence on synaptic activity reducing intraneuronal beta-..
  28. Nigrostriatal Tract Reconstruction
    JOHN RICHARD SLADEK; Fiscal Year: 2010
    ..As part of the design we tested the ability of "helper" grafts to stimulate and guide the extension of neurites from grafts of ventral mesencephalon that contained dopaminergic neurons...
  29. Molecular Pathways of Pain Generation in Osteoarthritis
    Anne Marie Malfait; Fiscal Year: 2013
    ..cartilage, bone, synovium, and meniscus) and with concomitant changes in the number and location of afferent neurites in the joint and dorsal root ganglia;2) Determine the effect of inhibiting ADAMTS-5 on pain detected in ..
  30. Early detection of Alzheimer's (MCI stage): Analysis of plasma cell-free miRNA
    Samuil R Umansky; Fiscal Year: 2013
    ..processes in vitro using quantitative analysis of cell-free miRNA in plasma: (1) brain-enriched miRNA present in neurites and synapses of hippocampus will be tested as potential biomarkers, and (2) concentrations of biomarker miRNA ..
  31. Vesicle trafficking defects &mitochondrial dysfunction related to a-syn toxicity
    PAVAN KUMAR AULUCK; Fiscal Year: 2013
    ..along with the deposition of [unreadable]-synuclein within neurons as compact aggregates known as Lewy bodies and neurites. While the causes of Parkinson disease and dementia with Lewy bodies remain enigmatic, familial forms of the ..
  32. The Role of DSCAM in Retinal Morphology and Function
    ABIGAIL LYNN DAVIDSON TADENEV; Fiscal Year: 2013
    ..In the wild-type eye, these neurons are evenly spaced and their neurites rarely self-cross...
  33. Genomic Approaches to Deciphering Memory Circuits
    Chris Sander; Fiscal Year: 2013
    ..Aplysia californica, our goal is to define systematically the molecular repertoire (genomic blueprint) of the neurites and individual synapses of the key neurons that make up this cellular ensemble...
  34. Molecular Mechanisms of Neural Circuit Formation
    MIRI KERENSA VANHOVEN; Fiscal Year: 2013
    ..Much is known about the early steps in circuit formation in which neurites extend to target regions containing the correct synaptic partners...
  35. Mechanism of transport of secretory vesicles in regulated secretory pathway
    JOSHUA JIN HYOUK PARK; Fiscal Year: 2012
    ..hypothesizes that snapin-CPE tail interacting proteins govern the anterograde transport of RSP vesicles along neurites, and are also involved in capturing these vesicles from the microtubule transport platform onto the actin network ..
  36. Interaction between DA, alpha-Synuclein and Chaperone-Mediated Autophagy
    Eugene V Mosharov; Fiscal Year: 2013
    ..disease (PD) is characterized by aggregation of alpha-synuclein (a-synuclein) into "Lewy bodies" and "Lewy neurites", and a progressive loss of specific neuronal populations...
  37. Cathepsin D as a therapeutic tool for Parkinson's disease
    Daniel Sevlever; Fiscal Year: 2012
    ..and familial PD cases are also characterized by the presence of brain inclusions known as Lewy bodies and Lewy neurites that are primarily composed of fibrillar 1-synuclein (1- syn)...
  38. Alpha-Synuclein Regulation by microRNAs
    Eunsung Junn; Fiscal Year: 2013
    ..Postmortem investigations have demonstrated fibrillar a-Syn aggregates in Lewy bodies and Lewy neurites in affected brain regions in these disorders...
  39. Cell Recognition in the developing Drosophila Brain
    S Lawrence Zipursky; Fiscal Year: 2013
    ..Each neuron expresses a unique combination of isoforms and this allows its neurites to distinguish between self and non-self...
  40. System for multidimensional analysis of growth and migration of neurons and neuro
    JACOB R GLASER; Fiscal Year: 2013
    ..precursors and neurite outgrowth: (i) identifying and follow up migrating neuronal precursors and growing neurites across many microscopic fields-of-view within large tissue cultures at low magnification and, simultaneously, (ii)..
  41. Alpha-Synuclein and the Synaptic Vesicle Cycle
    Robert H Edwards; Fiscal Year: 2013
    ..can cause autosomal dominant PD, and [unreadable]-synuclein accumulates in the Lewy bodies and dystrophic neurites of sporadic PD, suggesting a role for the protein in most forms of the disorder...
  42. High-content Image Analysis and Modeling for Neuron Assay Based Screening
    STEPHEN TC WONG; Fiscal Year: 2010
    ..tools for identifying quality hits in AD drug development and for determining cyptological profile of neurites. Upon the successful completion of the project, we will set up a website to disseminate the NCELLIQ software and ..
  43. Reconstruction of the ascending neural circuit from the spiral ganglion
    Zhengqing Hu; Fiscal Year: 2013
    ..This proposal will investigate the hypothesis that peripherally implanted neurons can form ascending neurites and make synaptic contacts with cochlear nucleus (CN)...
  44. Immunogenicity &efficacy of chimeric flu virus expressing Ab42 B cell epitope
    Michael G Agadjanyan; Fiscal Year: 2012
    ..Pathologically there is an increase in the presence in amyloid plaques, neurofibrillary tangles, dystrophic neurites and a general loss of neurons...
  45. Photopolymerization-Induced Topography Directs Neurite and Schwann Cell Alignment
    Marlan R Hansen; Fiscal Year: 2013
    ..Directing growth of spiral ganglion neuron (SGN) neurites into close proximity, or even contact, with the stimulating electrodes would likely improve spatial and temporal ..
  46. Cell surface molecules that require arrangement of retinal neurons and arbors
    Joshua R Sanes; Fiscal Year: 2013
    ..There is another sort of order, however, that has received less attention: the arrangement of cells and their neurites in the orthogonal (x-y) plane...
  47. PLASTICITY AND REGENERATION OF RETINAL SYNAPSES
    ELLEN S TOWNES ANDERSON; Fiscal Year: 2010
    ..synapse in the visual pathway, whereas in human and animal retinal degenerations, the photoreceptors grow long neurites or make new synapses with other retinal cells...
  48. The role of Fat3 in amacrine cell dendrite development.
    Lisa V Goodrich; Fiscal Year: 2013
    ..In vitro studies suggest that neurons initially extend multipotent neurites, one of which becomes an axon, leaving the remainder to differentiate as dendrites...
  49. Netrin signaling during neuronal development
    Elke Stein; Fiscal Year: 2010
    ..We will (I) characterize DCC- independent repulsion in vertebrates spinal neurites in vitro, (II) define the receptor complexes mediating DCC independent repulsion by using a combination of ..
  50. Establishing the Role of a Novel Conserved Gene in Dendrite Morphogenesis
    HANNES ERICH BUELOW; Fiscal Year: 2013
    ..determine whether the function of this gene is also required for development of other branched and unbranched neurites in C. elegans. Additionally, we will identify the vertebrate homologs of this gene...
  51. VEGF in Ischemic Neuroprotection, Neurodegeneration and Repair
    DAVID ALAN GREENBERG; Fiscal Year: 2013
    ..neurons (neurogenesis), improves outcome after experimental stroke, and stimulates outgrowth of nerve processes (neurites)...
  52. Molecular and Cellular Aspects of Corneal Nerve Regeneration
    Sandeep Jain; Fiscal Year: 2013
    ..We propose to explore our hypothesis that Sema7a acts on neurites and infiltrating immature myeloid cells (which we call YFP-MDSCs) in the cornea to promote neuroregeneration, ..
  53. Neuroimaging Biomarkers in Mouse Models of AD
    Robia G Pautler; Fiscal Year: 2012
    ..the extracellular deposition of amyloid-beta (Ab) aggregates known as plaques that are surrounded by dystrophic neurites and activated glial cells as well as intracellular neurofibrillary tangles that are comprised of ..
  54. Synaptic target selection in the thermotaxis neural circuit of C. elegans
    DANIEL A COLON RAMOS; Fiscal Year: 2010
    ..During development AIY contacts many neurites, but selects only three neurons (RIA, RIB and AIZ) as its postsynaptic partners...
  55. LIGHT STIMULATED CARDIAC PACING AND DEFIBRILLATION
    JULIET MORGAN; Fiscal Year: 1991
    ..Reactive structures included neurofibrillary tangles (NFT), plaque neurites, astrocytes, filaments, and neuronal nuclei. One Ab was specific for SDS-treated isolated NFT...
  56. AGING AND ALZHEIMER DEMENTIA--ROLE OF FIBROUS PROTEINS
    Shu Hui Yen; Fiscal Year: 2000
    ..perikarya and cell processes, in the form of neurofibrillary tangles (NFT), neuropil threads and dystrophic neurites in senile plaques...
  57. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..pattern formation, and these structures cordon off developing groups of functionally distinct neurons and their neurites. In the developing caudate-putamen (neostriatum), these boundaries surround different compartments of a ..
  58. CRCNS: Activity-dependent growth cone guidance
    Kyonsoo Hong; Fiscal Year: 2012
    ..Growth cones, at the tips of growing neurites, navigate through a variety ofextracellular environments in which they must sense, integrate and respond to a ..
  59. MECHANISM OF PC12 CELL ADHESION TO COLLAGEN AND LAMININ
    David Turner; Fiscal Year: 1991
    ..cells derived from a rat pheochromocytoma, resemble sympathetic neurons in many respects, including extension of neurites in response to nerve growth factor...
  60. Modeling Huntington's Disease in Drosophila
    J Littleton; Fiscal Year: 2009
    ..decreased lifespan and time-dependent formation of huntingtin aggregates specifically in the cytoplasm and neurites. Huntingtin aggregates sequester other expanded polyglutamine proteins in the cytoplasm and lead to synaptic ..
  61. Surface Modified Nanofibers for Nerve Regeneration
    JOSEPH COREY; Fiscal Year: 2009
    ..which allows target muscle to atrophy preventing reinnervation and functional motor recovery after regenerating neurites arrive. Nerve guides that accelerate regeneration could improve motor recovery after nerve repair...
  62. Automated reconstruction of neurites from 3D microscopy image stacks
    Armen Stepanyants; Fiscal Year: 2012
    ..Such tracings can be time consuming and/or are prone to errors in situations where faint or beaded neurites diffusely cover large volumes. This is usually the case with tracing axons of cortical pyramidal neurons, e.g...
  63. DEVELOPMENT AND MODULATION OF PRESYNAPTIC ION CHANNELS
    STEPHEN MERINEY; Fiscal Year: 2000
    ..Ca++ and calcium-activated K+ channels) expressed at transmitter-releasing varicosities that form along neurites in cultures of Xenopus spinal cord neurons and myocytes...
  64. PATHOLOGICAL ALTERATIONS IN ALZHEIMER'S DISEASE
    Bradley Hyman; Fiscal Year: 1993
    ..In addition, there is a recently-described accumulation of both amyloid protein and abnormal neurites in the neuropil...
  65. PET IMAGING PROBES FOR AMYLOID IN ALZHEIMERS AND AGING
    William Klunk; Fiscal Year: 2005
    ..in plaques and vascular amyloid and hyper-phosphorylated tau protein in neurofibrillary tangles, dystrophic neurites and neuropil threads...
  66. RAGE and a Novel Tumor Axis
    Ann Schmidt; Fiscal Year: 2005
    ..system, upregulation of RAGE and its ligand amphoterin occurs, especially at the leading edge of advancing neurites. In vitro, amphoterin-RAGE interaction mediates outgrowth of cerebral cortical neurites, as the process is ..
  67. DEVELOPMENT OF INNERVATION TOPOGRAPHY IN MUSCLE
    Michael Laskowski; Fiscal Year: 2004
    ..We have found selective growth of embryonic spinal cord neurites on membranes derived from embryonic rostral or caudal muscles or from transgenic muscle cell lines bearing a ..
  68. HUMAN OLFACTORY TISSUE--AGING ALZHEIMER'S DISEASE
    BARBARA TALAMO; Fiscal Year: 1993
    ..The investigators have shown that olfactory tissue taken at autopsy from AD patients shows ectopic neurites that invade the epithelium and are immunoreactive for phosphorylated cytoskeletal proteins not normally found in ..