unmyelinated nerve fibers

Summary

Summary: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the unmyelinated nerve fibers are small. The axons to SCHWANN CELLS ratio is greater in the unmyelinated nerve fibers than that in the myelinated fiber (NERVE FIBERS, MYELINATED) which is 1:1. Usually several axons are surrounded by a single Schwann cell in the unmyelinated nerve fibers. Therefore, each unmyelinated fiber is not completely covered by the MYELIN SHEATH formed by the Schwann cell. Unmyelinated nerve fibers conduct impulses at low velocities. They represent the majority of peripheral sensory and autonomic fibers. They are also found in the spinal cord and brain.

Top Publications

  1. ncbi Role of capsaicin-sensitive primary afferent inputs from the masseter muscle in the C1 spinal neurons responding to tooth-pulp stimulation in rats
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, 102 8159 Tokyo, Japan
    Exp Brain Res 160:107-17. 2005
  2. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
  3. ncbi The postnatal reorganization of primary afferent input and dorsal horn cell receptive fields in the rat spinal cord is an activity-dependent process
    Simon Beggs
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Eur J Neurosci 16:1249-58. 2002
  4. ncbi Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression
    Adam W Hantman
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 24:836-42. 2004
  5. ncbi A reliable method for the preferential activation of C- or A-fibre heat nociceptors
    Simon McMullan
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Neurosci Methods 138:133-9. 2004
  6. ncbi Induction of synaptic long-term potentiation after opioid withdrawal
    Ruth Drdla
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria
    Science 325:207-10. 2009
  7. ncbi Glial cell line-derived neurotrophic factor alters axon schwann cell units and promotes myelination in unmyelinated nerve fibers
    Ahmet Hoke
    Johns Hopkins Hospital, Department of Neurology, Baltimore, Maryland 21205, and Amgen, Inc, Thousand Oaks, California 91320 1799, USA
    J Neurosci 23:561-7. 2003
  8. ncbi Pre- and postsynaptic contributions of voltage-dependent Ca2+ channels to nociceptive transmission in rat spinal lamina I neurons
    B Heinke
    Brain Research Institute, Vienna University Medical School, Spitalgasse 4, A 1090 Vienna, Austria
    Eur J Neurosci 19:103-11. 2004
  9. ncbi Altered temporal pattern of evoked afferent activity in a rat model of vincristine-induced painful peripheral neuropathy
    K D Tanner
    Department of Oral and Maxillofacial Surgery, Medicine, and Anatomy, Room C 555, Campus Box 0440, NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Neuroscience 118:809-17. 2003
  10. pmc Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges
    Roberto De Col
    Institute for Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Physiol 586:1089-103. 2008

Detail Information

Publications200 found, 100 shown here

  1. ncbi Role of capsaicin-sensitive primary afferent inputs from the masseter muscle in the C1 spinal neurons responding to tooth-pulp stimulation in rats
    M Takeda
    Department of Physiology, School of Dentistry at Tokyo, Nippon Dental University, 1 9 20, Fujimi cho, Chiyoda ku, 102 8159 Tokyo, Japan
    Exp Brain Res 160:107-17. 2005
    ....
  2. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ....
  3. ncbi The postnatal reorganization of primary afferent input and dorsal horn cell receptive fields in the rat spinal cord is an activity-dependent process
    Simon Beggs
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Eur J Neurosci 16:1249-58. 2002
    ..The results indicate that the normal postnatal structural and functional development of A-fibre sensory connectivity within the spinal cord is an activity-dependent process requiring NMDA receptor activation...
  4. ncbi Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression
    Adam W Hantman
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 24:836-42. 2004
    ....
  5. ncbi A reliable method for the preferential activation of C- or A-fibre heat nociceptors
    Simon McMullan
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK
    J Neurosci Methods 138:133-9. 2004
    ..In contrast thresholds of responses to fast rates of skin heating were unchanged, indicating that nociceptors activated by this stimulus were capsaicin-insensitive A-fibre heat nociceptors...
  6. ncbi Induction of synaptic long-term potentiation after opioid withdrawal
    Ruth Drdla
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria
    Science 325:207-10. 2009
    ..These findings provide a previously unrecognized target to selectively combat pro-nociceptive effects of opioids without compromising opioid analgesia...
  7. ncbi Glial cell line-derived neurotrophic factor alters axon schwann cell units and promotes myelination in unmyelinated nerve fibers
    Ahmet Hoke
    Johns Hopkins Hospital, Department of Neurology, Baltimore, Maryland 21205, and Amgen, Inc, Thousand Oaks, California 91320 1799, USA
    J Neurosci 23:561-7. 2003
    ..This study demonstrates that the administration of high doses of a growth factor to adult rats can change the phenotype of nerve fibers from unmyelinated to myelinated...
  8. ncbi Pre- and postsynaptic contributions of voltage-dependent Ca2+ channels to nociceptive transmission in rat spinal lamina I neurons
    B Heinke
    Brain Research Institute, Vienna University Medical School, Spitalgasse 4, A 1090 Vienna, Austria
    Eur J Neurosci 19:103-11. 2004
    ....
  9. ncbi Altered temporal pattern of evoked afferent activity in a rat model of vincristine-induced painful peripheral neuropathy
    K D Tanner
    Department of Oral and Maxillofacial Surgery, Medicine, and Anatomy, Room C 555, Campus Box 0440, NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Neuroscience 118:809-17. 2003
    ....
  10. pmc Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges
    Roberto De Col
    Institute for Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Physiol 586:1089-103. 2008
    ..Since the process is primarily dependent upon sodium channel availability, tracking conduction velocity provides a means of accessing relative changes in the excitability of nociceptive neurons...
  11. pmc Distinctive membrane and discharge properties of rat spinal lamina I projection neurones in vitro
    Ruth Ruscheweyh
    Brain Research Institute, Department of Neurophysiology, Medical University of Vienna, Spitalgasse 4, A 1090 Vienna, Austria
    J Physiol 555:527-43. 2004
    ..Intracellular labelling with Lucifer yellow showed that projection neurones had larger somata than unidentified neurones and many had a considerable extension in the mediolateral plane...
  12. ncbi Synaptic amplifier of inflammatory pain in the spinal dorsal horn
    Hiroshi Ikeda
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Science 312:1659-62. 2006
    ..This model integrates known signal transduction pathways of hyperalgesia without contradiction...
  13. ncbi Spontaneous pain, both neuropathic and inflammatory, is related to frequency of spontaneous firing in intact C-fiber nociceptors
    Laiche Djouhri
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 26:1281-92. 2006
    ..Overall, SFL was related to SA rate in intact C-nociceptors. Both L5 degeneration and chromic gut cause inflammation. Therefore, both SA and SFL/spontaneous pain after nerve injury (mSNA) may result from cumulative neuroinflammation...
  14. ncbi Tumor necrosis factor-alpha induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: the role of NF-kappa B, JNK and p38 MAPK
    Yan Ling Liu
    Pain Research Center, Zhongshan Medical School of Sun Yat Sen University, 510089 Guangzhou, PR China
    Neuropharmacology 52:708-15. 2007
    ..These results suggest that TNF-alpha and its downstream molecules may have no acute effect on spinal synaptic transmission in intact animals and induce LTP in rats with neuropathic pain produced by nerve injury...
  15. ncbi Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia
    Hiroshi Ikeda
    Institute of Physiology and Pathophysiology, Heidelberg University, D 69120 Heidelberg, Germany
    Science 299:1237-40. 2003
    ..Thereby, memory traces of painful events are retained...
  16. ncbi Electrophysiological characterisations of rat lamina I dorsal horn neurones and the involvement of excitatory amino acid receptors
    Lucinda C Seagrove
    Department of Pharmacology, University College London, Gower Street, WC1E 6BT London, UK
    Pain 108:76-87. 2004
    ..Overall, this study describes a high threshold, AMPA receptor possessing population of lamina I neurones, which seem to lack functional NMDA receptors, and are partially controlled by GABA(A) receptor activity...
  17. pmc Characterization of three different sensory fibers by use of neonatal capsaicin treatment, spinal antagonism and a novel electrical stimulation-induced paw flexion test
    Misaki Matsumoto
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852 8521, Japan
    Mol Pain 2:16. 2006
    ..These results also suggest that the EPF analysis is useful for the evaluation of plasticity in sensory functions in animal disease models...
  18. pmc Synaptic input of rat spinal lamina I projection and unidentified neurones in vitro
    Anne Dahlhaus
    Center for Brain Research, Department of Neurophysiology, Medical University of Vienna, Vienna, Austria
    J Physiol 566:355-68. 2005
    ....
  19. ncbi Selective loss of unmyelinated nerve fibers after extracorporeal shockwave application to the musculoskeletal system
    J Hausdorf
    Department of Orthopaedic Surgery, University of Munich, Klinikum Grosshadern, Munich, Germany
    Neuroscience 155:138-44. 2008
    ..Application of ESW resulted in a selective, substantial loss of unmyelinated nerve fibers within the femoral nerve of the treated hind limb, whereas the sciatic nerve of the treated hind limb ..
  20. ncbi Receptive field properties of unmyelinated tactile afferents in the human skin
    Johan Wessberg
    Department of Physiology, Goteborg University, SE 40530 Goteborg, Sweden
    J Neurophysiol 89:1567-75. 2003
    ..The properties of the fields seem consistent with a role of tactile C afferents to provide information about pleasant touch and skin-to-skin contacts to central structures controlling emotions and affiliative behavior...
  21. pmc Spinal dorsal horn neuronal responses to myelinated versus unmyelinated heat nociceptors and their modulation by activation of the periaqueductal grey in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    J Physiol 576:547-56. 2006
    ..The data are discussed in relation to the role of the DL/L-PAG in mediating active coping strategies...
  22. ncbi Altered temporal pattern of mechanically evoked C-fiber activity in a model of diabetic neuropathy in the rat
    X Chen
    Departments of Anatomy, Medicine and Oral and Maxillofacial Surgery, Division of Neuroscience, NIH Pain Center University of California, San Francisco, C 522 Box 0440, University of California, San Francisco, CA 94143 0440, USA
    Neuroscience 121:1007-15. 2003
    ..Our data demonstrate specific changes in firing pattern of high-firing C-fibers in the rat model of painful neuropathy produced by STZ-diabetes that might contribute to the symptoms experienced by patients...
  23. ncbi Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 5:1319-26. 2002
    ....
  24. ncbi The involvement of glia in long-term plasticity in the spinal dorsal horn of the rat
    Jun Yi Ma
    Institute of Neurobiology, Fudan University, Shanghai, China
    Neuroreport 13:1781-4. 2002
    ..These data suggest that spinal glial cells may modulate the central sensitization of nociceptive neurons via NMDA receptors...
  25. ncbi Acute nerve injury induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn of intact rat
    Hong Mei Zhang
    Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, Guangzhou, China
    Sheng Li Xue Bao 56:591-6. 2004
    ..The results further support the notion that LTP of C-fiber evoked field potentials may underlie neuropathic pain...
  26. ncbi Induction of long-term potentiation of C fibre-evoked spinal field potentials requires recruitment of group I, but not group II/III metabotropic glutamate receptors
    Jon Jatsu Azkue
    School of Medicine and Dentistry, The University of the Basque Country, Sarriena s n 48940, Leioa, Spain
    Pain 106:373-9. 2003
    ....
  27. pmc Long-term potentiation at C-fibre synapses by low-level presynaptic activity in vivo
    Ruth Drdla
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Mol Pain 4:18. 2008
    ..These pathways match those leading to hyperalgesia in behaving animals and humans. We thus propose that LTP induced by low-level activity in C-fibres may underlie some forms of hyperalgesia...
  28. ncbi Roles of CaMKII, PKA, and PKC in the induction and maintenance of LTP of C-fiber-evoked field potentials in rat spinal dorsal horn
    Hong Wei Yang
    Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, Guangzhou 510089, Peoples Republic of China
    J Neurophysiol 91:1122-33. 2004
    ..These results suggest that activation of CaMKII, PKA, and PKC may be crucial for the induction and the early-phase but not for the late-phase maintenance of the spinal LTP...
  29. ncbi Partial reversal of conduction slowing during repetitive stimulation of single sympathetic efferents in human skin
    M Campero
    Good Samaritan Hospital and Medical Center and Oregon Health Sciences University, Portland, OR, USA
    Acta Physiol Scand 182:305-11. 2004
    ..Other C fibres slow progressively at 2 Hz (type 1), reach a latency plateau (type 2) or hardly slow at all (type 3)...
  30. pmc Inflammation reduces mechanical thresholds in a population of transient receptor potential channel A1-expressing nociceptors in the rat
    James P Dunham
    Department of Physiology and Pharmacology, School of Medical Sciences, University Walk, University of Bristol, Bristol BS8 1TD, UK
    Eur J Neurosci 27:3151-60. 2008
    ..Our data show that a subset of afferents is sensitized to mechanical stimulation by inflammation and that these afferents are defined by expression of TRPA1...
  31. pmc Velocity recovery cycles of single C fibres innervating rat skin
    Annette George
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Physiol 578:213-32. 2007
    ..These data indicate axonal membrane differences between different functional classes of C fibres, which resemble those previously described in human C fibres...
  32. ncbi Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 24:8310-21. 2004
    ....
  33. ncbi Release of BDNF and GABA in the dorsal horn of neuropathic rats
    Isobel Lever
    Sensory Function, Centre for Neuroscience Research, London WC1, E6BN, UK
    Eur J Neurosci 18:1169-74. 2003
    ..Furthermore, reduced availability of sensory neuron-derived BDNF might contribute to the reduced GABAergic tone in the dorsal horn of neuropathic rats...
  34. ncbi Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat
    Elizabeth K Joseph
    Department of Medicine, Division of Neuroscience and Biomedical Sciences Program, and UCSF NIH Pain Center, University of California, San Francisco, CA 94143 0440, USA
    Pain 107:147-58. 2004
    ..This study provides evidence for a novel, calcium-dependent, mechanism for neuropathic pain in a model of AIDS therapy-induced painful peripheral neuropathy...
  35. ncbi Integrin signaling in inflammatory and neuropathic pain in the rat
    Olayinka A Dina
    Departments of Medicine and Oral and Maxillofacial Surgery, Division of Neuroscience and Biomedical Sciences Program, NIH Pain Center UCSF, CA 94143 0440, USA
    Eur J Neurosci 19:634-42. 2004
    ..These results strongly implicate specific integrins in the maintenance of inflammatory and neuropathic hyperalgesia...
  36. ncbi Cyclooxygenase-1-derived prostaglandins in the periaqueductal gray differentially control C- versus A-fiber-evoked spinal nociception
    J Lianne Leith
    Department of Physiology, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 27:11296-305. 2007
    ..Thus, effects of centrally acting prostaglandins are pivotal, we suggest, to both the understanding of nociceptive processing and the development of new analgesic drugs...
  37. ncbi Role of phosphorylation of ERK in induction and maintenance of LTP of the C-fiber evoked field potentials in spinal dorsal horn
    Wen Jun Xin
    Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, Guangzhou, People s Republic of China
    J Neurosci Res 84:934-43. 2006
    ..Our results suggested that activation of ERK/CREB pathway in spinal dorsal neurons is necessary for induction and maintenance of long-term potentiation of the C-fiber evoked field potentials...
  38. ncbi Role of TRPM8 and TRPA1 for cold allodynia in patients with cold injury
    Barbara Namer
    Department of Physiology and Pathophysiology, University of Erlangen, Universitätsstr 17, 91054 Erlangen, Germany
    Pain 139:63-72. 2008
    ..We conclude from these data that the mechanisms for the induction of cold allodynia in the patients with cold injury are independent of TRPM8 or TRPA1 and differ therefore from neuropathic pain patients...
  39. ncbi Pathological C-fibres in patients with a chronic painful condition
    Kristin Ørstavik
    Department of Neurology, Ulleval University Hospital, Oslo, Norway
    Brain 126:567-78. 2003
    ..This is the first systematic study of single C-fibres in patients and it shows an active contribution of mechano-insensitive fibres to chronic pain...
  40. ncbi Two types of C nociceptors in human skin and their behavior in areas of capsaicin-induced secondary hyperalgesia
    Jordi Serra
    Neuropathic Pain Unit, Hospital General de Catalunya, C Josep Trueta s n, 08190 Sant Cugat del Valles, Barcelona, Spain
    J Neurophysiol 91:2770-81. 2004
    ..This sensitization may contribute a peripheral C fiber component to secondary hyperalgesia...
  41. pmc Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Mol Pain 2:25. 2006
    ..All these results suggest that the loss of pain transmission through polymodal C-fiber neurons is also mediated by the LPA1 activation following nerve injury...
  42. ncbi Responsiveness of C-fiber nociceptors to punctate force-controlled stimuli in isolated rat skin: lack of modulation by inflammatory mediators and flurbiprofen
    T Schlegel
    Institut fur Physiologie und Experimentelle Pathophysiologie, Universitat Erlangen Nurnberg, Universitatsstrasse 17, D 91054 Erlangen, Germany
    Neurosci Lett 361:163-7. 2004
    ..In conclusion, even refined mechanostimulation was unable to demonstrate sensitization of the predominant nociceptor classes in the rat skin...
  43. ncbi Involvement of nitric oxide in long-term potentiation of spinal nociceptive responses in rats
    Xi Chun Zhang
    Institute of Neurobiology, Fudan University, 220 Handan Road, Shanghai 200433, People s Republic of China
    Neuroreport 16:1197-201. 2005
    ..These results suggest the involvement of nitric oxide in the spinal long-term potentiation of C-fiber-evoked field potentials and related behavior changes...
  44. ncbi The population response of A- and C-fiber nociceptors in monkey encodes high-intensity mechanical stimuli
    Robert M Slugg
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 24:4649-56. 2004
    ..These data provide evidence that both C-fiber and A-fiber nociceptors may encode high-intensity mechanical stimuli...
  45. ncbi The role of uninjured C-afferents and injured afferents in the generation of mechanical hypersensitivity after partial peripheral nerve injury in the rat
    Jun Ho Jang
    Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul 120 752, South Korea
    Exp Neurol 204:288-98. 2007
    ....
  46. pmc Localization of soluble guanylyl cyclase in the superficial dorsal horn
    Jin Dong Ding
    Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, 27599, USA
    J Comp Neurol 495:668-78. 2006
    ..NO may also influence local circuit neurons, but it does not act on unmyelinated primary afferent terminals via sGC...
  47. ncbi Differential activation of trigeminal C or Adelta nociceptors by infrared diode laser in rats: behavioral evidence
    Alexander Tzabazis
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305, USA
    Brain Res 1037:148-56. 2005
    ..We conclude that different settings of the stimulator used in this study were capable of selectively activating trigeminal Adelta or C thermonociceptors...
  48. ncbi Activation and sensitization of C and Adelta afferent fibers mediated by P2X receptors in rat dorsal skin
    Qi Zhang
    Key Laboratory of Environment and Genes Related to Diseases Xi an Jiaotong University, Ministry of Education, Xi an, Shaanxi, PR China
    Brain Res 1102:78-85. 2006
    ..These results suggest that peripheral P2X receptors are involved in mediating peripheral excitation of C and Adelta fibers...
  49. ncbi Modification of classical neurochemical markers in identified primary afferent neurons with Abeta-, Adelta-, and C-fibers after chronic constriction injury in mice
    Ruth Ruscheweyh
    Department of Neurophysiology, Center for Brain Research, Medical University of Vienna, A 1090 Vienna, Austria
    J Comp Neurol 502:325-36. 2007
    ..The extent of up-regulation of NPY showed a strong inverse correlation with the degree of heat hyperalgesia...
  50. ncbi Acute painful neuropathy in thallium poisoning
    H C Kuo
    Department of Neurology, Chang Gung Memorial Hospital and University, Taipei, Taiwan
    Neurology 65:302-4. 2005
    ..Quantitative sensory testing also revealed an impairment of pinprick, temperature, and touch sensations. Cutaneous nerve biopsy confirmed a loss of epidermal nerves indicating an involvement of the small sensory nerves...
  51. ncbi Heat sensitization in skin and muscle nociceptors expressing distinct combinations of TRPV1 and TRPV2 protein
    K K Rau
    Dept of Oral Surgery and Diagnostic Sciences, Div of Neuroscience, Box 100416, JHMHC, Univ of Florida College of Dentistry, Gainesville, FL 32610, USA
    J Neurophysiol 97:2651-62. 2007
    ..The expression pattern of these proteins are specific to subclasses of physiologically identified C and A fiber nociceptors with highly restricted tissue targets...
  52. ncbi Sympathetic influence on capsaicin-evoked enhancement of dorsal root reflexes in rats
    Jing Wang
    Dept of Anatomy and Neuroscience, The Univ of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 92:2017-26. 2004
    ....
  53. ncbi Neonatal chronic hind paw inflammation alters sensitization to intradermal capsaicin in adult rats: a behavioral and immunocytochemical study
    Andrea G Hohmann
    Neuroscience and Behavior Program, Department of Psychology, The University of Georgia, Athens, GA 30602 3013, USA
    J Pain 6:798-808. 2005
    ....
  54. ncbi Involvement of peripheral purinoceptors in sympathetic modulation of capsaicin-induced sensitization of primary afferent fibers
    Yong Ren
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 96:2207-16. 2006
    ..Combined with our previous study, our data also provide further evidence that the sensitization of primary afferent nociceptors is subject to sympathetic modulation by activation of P2X as well as alpha(1)-adrenergic receptors...
  55. ncbi Acidic pH and capsaicin activate mechanosensitive group IV muscle receptors in the rat
    Ulrich Hoheisel
    Institut fur Pharmakologie und Toxikologie, Charite, Humboldt Universitat, Dorotheenstrasse 94, D 10117 Berlin, Germany
    Pain 110:149-57. 2004
    ..The data show that (1) a high proportion of group IV muscle receptors are responsive to an increased extracellular hydrogen ion concentration, and (2) a subpopulation of these units are sensitive to both acidic pH and ATP...
  56. ncbi trkA is expressed in nociceptive neurons and influences electrophysiological properties via Nav1.8 expression in rapidly conducting nociceptors
    Xin Fang
    Department of Physiology, Medical School, University of Bristol, Bristol BS8 1TD, United Kingdom
    J Neurosci 25:4868-78. 2005
    ..8 are related to, and perhaps limited by, expression levels of trkA. This view is supported by a positive correlation between immuno-intensities of trkA and Nav1.8 in A-fiber, but not C-fiber, nociceptors...
  57. ncbi Local and descending circuits regulate long-term potentiation and zif268 expression in spinal neurons
    Lars Jørgen Rygh
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Eur J Neurosci 24:761-72. 2006
    ..Our results support the suggestion that the generation of LTP in dorsal horn neurons following peripheral injury may be one mechanism whereby acute pain can be transformed into a long-term pain state...
  58. ncbi Mechanoreceptive and nociceptive responses in the central nervous system of goldfish (Carassius auratus) and trout (Oncorhynchus mykiss)
    Rebecca Dunlop
    School of Biology and Biochemistry, Medical Biology Centre, Queen s University of Belfast, Belfast, Northern Ireland
    J Pain 6:561-8. 2005
    ..This study has shown that there is neuronal activity in all brain areas including the telencephalon, suggesting a nociceptive pathway from the periphery to the higher central nervous system of fish...
  59. ncbi Clonidine depresses LTP of C-fiber evoked field potentials in spinal dorsal horn via NO-cGMP pathway
    Yu Xing Ge
    Pain Research Center, Department of Physiology, Zhongshan Medical School of Sun Yat Sen University, Guangzhou, PR China
    Brain Res 1118:58-65. 2006
    ..These results suggest that clonidine may exert analgesic effect by depressing the synaptic plasticity in spinal dorsal horn, via activation of muscarinic receptor-NO-cGMP pathway...
  60. ncbi Modification of cornea-evoked reflex blinks in rats
    Victor M Henriquez
    Department of Neurobiology, SUNY Stony Brook, Stony Brook, NY 11794 5230, USA
    Exp Brain Res 163:445-56. 2005
    ..Thus, activation of Vc/C1 is a previously unidentified mechanism for modulating cornea-evoked blinks...
  61. ncbi Degeneration of myelinated efferent fibers prompts mitosis in Remak Schwann cells of uninjured C-fiber afferents
    Beth B Murinson
    Department of Neurology, The Johns Hopkins School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 25:1179-87. 2005
    ..In summary, we find that the degeneration of myelinated motor axons produced signals that were mitogenic for nonmyelinating Schwann cells with intact axons but not for myelinating Schwann cells with intact axons...
  62. ncbi GABA(A) receptor facilitation of neurokinin release from primary afferent terminals in the rat spinal cord
    L Lao
    Center for Neurovisceral Sciences and Women s Health, CURE Digestive Diseases Research Center, Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA
    Neuroscience 130:1013-27. 2005
    ....
  63. ncbi Effects of neonatal C-fiber depletion on the integration of paired-whisker inputs in rat barrel cortex
    R Farazifard
    Neuroscience Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
    Exp Brain Res 162:115-21. 2005
    ..These results suggest that the inhibitory receptive field properties of low-threshold mechanical somatosensory cells are influenced by C-fibers...
  64. ncbi Comparison of Fos expression within the ferret's spinal trigeminal nuclear complex evoked by electrical or noxious-thermal pulpal stimulation
    Siriporn Chattipakorn
    Department of Odontology and Oral Pathology, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand
    J Pain 6:569-80. 2005
    ..Our results suggest that a population of neurons in Vc and Vi/Vc contribute to painful sensations originating from the dentition...
  65. ncbi Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder
    Hiroko Matsuyoshi
    Department of Urology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Res 1119:115-23. 2006
    ....
  66. ncbi Differential growth of axons from sensory and motor neurons through a regenerative electrode: a stereological, retrograde tracer, and functional study in the rat
    P Negredo
    Department of Morphology, Autonoma University, Medical School, C Arzobispo Morcillo s n, 28029 Madrid, Spain
    Neuroscience 128:605-15. 2004
    ..They also suggest that fine fibers may be at an advantage over large ones to regenerate through the RE...
  67. ncbi Sympathetic modulation of activity in Adelta- and C-primary nociceptive afferents after intradermal injection of capsaicin in rats
    Yong Ren
    Department of Neuroscience and Cell Biology, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 1069, USA
    J Neurophysiol 93:365-77. 2005
    ....
  68. ncbi Local application of morphine suppresses glutamate-evoked activities of C and Adelta afferent fibers in rat hairy skin
    Yu ling Tian
    Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi 710061, PR China
    Brain Res 1059:28-34. 2005
    ..These findings suggest that local application of morphine can suppress the glutamate-evoked activities of the fine fibers in rat hairy skin and thus provide an electrophysiological evidence for peripheral antinociception of opioids...
  69. ncbi Effect of morphine on the release of excitatory amino acids in the rat hind instep: Pain is modulated by the interaction between the peripheral opioid and glutamate systems
    Y H Jin
    Department of Pharmacology, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Neuroscience 138:1329-39. 2006
    ....
  70. ncbi Inhibitory effect of capsaicin evoked trigeminal pain on warmth sensation and warmth evoked potentials
    Massimiliano Valeriani
    Divisione di Neurologia, Ospedale Pediatrico Bambino Gesu, IRCCS, Piazza Sant Onofrio 4, 00165 Rome, Italy
    Exp Brain Res 160:29-37. 2005
    ..This is the first neurophysiological evidence in humans of an inhibitory effect of pain on warmth sensation...
  71. ncbi Oxytocin actions on afferent evoked spinal cord neuronal activities in neuropathic but not in normal rats
    Miguel Condés-Lara
    Departamento de Neurofisiologia, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Campus UNAM Juriquilla, Mexico
    Brain Res 1045:124-33. 2005
    ..Our results point out an anti-algesic OT effect in neuropathic rats...
  72. ncbi Potassium- and capsaicin-induced release of agmatine from spinal nerve terminals
    Cory J Goracke-Postle
    Department of Pharmaceutics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurochem 102:1738-48. 2007
    ..These results support the proposal that agmatine may serve as a spinal neuromodulator involved in pain processing...
  73. ncbi Differential opioid inhibition of C- and A delta- fiber mediated thermonociception after stimulation of the nucleus raphe magnus
    Ying Lu
    Department of Anesthesiology, University of Illinois at Chicago, Chicago, Illinois, USA
    Anesth Analg 98:414-9, table of contents. 2004
    ..These findings suggest that nociception evoked by the activation of A delta or C fiber nociceptors is under pharmacologically distinguishable descending control from the nucleus raphe magnus...
  74. pmc Action potential conduction in the terminal arborisation of nociceptive C-fibre afferents
    C Weidner
    Department of Physiology and Experimental Pathophysiology, University of Erlangen Nurnberg, Germany
    J Physiol 547:931-40. 2003
    ..This indicates that the terminal branches are equipped with membrane proteins that are different from those of the parent axon...
  75. ncbi Dorsal horn NK1-expressing neurons control windup of downstream trigeminal nociceptive neurons
    Jerome Coste
    Inserm E216, Neurobiologie de la douleur trigeminale, Faculte de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000 Clermont Ferrand, France
    Pain 137:340-51. 2008
    ..We conclude that, in contrast to central sensitization that is controlled by a spino-bulbo-spinal loop, Sp5O WDR neuron windup is regulated through a local circuit activated by MDH lamina III NK1Rs...
  76. ncbi Transient receptor potential channel A1 involved in sensory transduction of rat urinary bladder through C-fiber pathway
    Shuqi Du
    Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan
    Urology 70:826-31. 2007
    ..To investigate the expression and function of the transient receptor potential (TRP) channel A1 in the afferent pathway of rat urinary bladder. The TRPA1 is a candidate for both mechanosensory transduction and nociception...
  77. ncbi Role of primary afferents in spinal cord stimulation-induced vasodilation: characterization of fiber types
    Satoshi Tanaka
    Department of Physiology, University of Oklahoma Health Sciences Center, P O Box 26901, Oklahoma City, OK 73190, USA
    Brain Res 959:191-8. 2003
    ..It is concluded that SCS-induced vasodilation at <or=60% of MT may be mediated via only the myelinated fibers, whereas vasodilation at >or=90% of MT may also involve antidromic activation of some unmyelinated C-fibers...
  78. ncbi Expression of P2X3 receptor in the trigeminal sensory nuclei of the rat
    Yun Sook Kim
    Department of Oral Anatomy and Neurobiology, BK21, School of Dentistry, Kyungpook National University, Daegu 700 412, Korea
    J Comp Neurol 506:627-39. 2008
    ..These results suggest that orofacial nociceptive information may be transmitted via P2X(3) (+) afferents to all TBSN and that it may be processed differently in different TBSN...
  79. ncbi C-fiber modulation of the rat type I slowly adapting mechanoreceptor
    J Zhang
    Department of Physiology, University of Utah School of Medicine, 410 Chipeta Way, Room 156, Salt Lake City, UT 84108 1297, USA
    Neuroscience 115:797-804. 2002
    ..staining revealed both substance P- and calcitonin gene-related peptide-like immunoreactivity in small unmyelinated nerve fibers entering the touch dome. These results support the concepts that (1)...
  80. ncbi Only minor spinal motor reflex effects from feline group IV muscle nociceptors
    Eike D Schomburg
    Institute of Physiology, University of Gottingen, Humboldtallee 23, D 37073 Gottingen, Germany
    Neurosci Res 44:213-223. 2002
    ..It is concluded that the main functional meaning of group IV muscle afferents, which respond preferentially with a higher threshold to mechanical stimuli, is probably less related to reflex motor control than that of group III afferents...
  81. ncbi Persistent low-frequency spontaneous discharge in A-fiber and C-fiber primary afferent neurons during an inflammatory pain condition
    Wen Hua Xiao
    Department of Anesthesia and Centre for Research on Pain, McGill University, Montreal, Quebec, Canada
    Anesthesiology 107:813-21. 2007
    ..However, there is evidence that inflammatory pain mechanisms differ from acute pain mechanisms and that the mechanisms that drive and modulate inflammatory pain may evolve over time...
  82. ncbi Skin denervation, neuropathology, and neuropathic pain in a laser-induced focal neuropathy
    Hou Yu Chiang
    Department of Anatomy and Cell Biology, National Taiwan University College of Medicine, Taipei 10018, Taiwan
    Neurobiol Dis 18:40-53. 2005
    ..With this approach, the extent of nerve injury can be quantified. Both small-diameter epidermal nerves and large-diameter sensory and motor nerves are susceptible to laser-induced injury of different degrees...
  83. ncbi Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats
    G M Khan
    Department of Anesthesiology H187, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Neuroscience 114:291-9. 2002
    ..Our electrophysiological data provide substantial new evidence that the abnormal sensory input from Adelta- and Abeta-fiber afferents may play an important role in diabetic neuropathic pain...
  84. pmc An inhibitory interaction of human cortical responses to stimuli preferentially exciting Adelta or C fibers
    T D Tran
    Department of Neurology, University of Michigan, Ann Arbor, MI 48105, USA
    Neuroscience 152:798-808. 2008
    ..This suppressive interaction of cortical responses suggests contrasting and possibly mutually exclusive sensorimotor functions mediated through the Adelta and C fiber afferent channels...
  85. ncbi Heat hyperalgesia in humans: assessed by different stimulus temperature profiles
    Aysen Yucel
    Laboratory for Experimental Pain Research, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    Eur J Pain 6:357-64. 2002
    ..There were no heat hyperalgesia in the control arm. In conclusion, hyperalgesia to suprathreshold heat stimuli was observed in the secondary hyperalgesic area and C-fibres play an important role in the primary hyperalgesia to heat...
  86. ncbi Effect of extracellular calcium on excitability of guinea pig airway vagal afferent nerves
    Bradley J Undem
    Johns Hopkins School of Medicine, Department of Medicine, Baltimore, MD 21224, USA
    J Neurophysiol 89:1196-204. 2003
    ....
  87. ncbi Cocaine- and amphetamine-regulated transcript peptide (CART) is present in peptidergic C primary afferents and axons of excitatory interneurons with a possible role in nociception in the superficial laminae of the rat spinal cord
    Márk Kozsurek
    Szentágothai Laboratory, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary
    Eur J Neurosci 26:1624-31. 2007
    ..This strongly suggests that CART peptide can affect glutamatergic neurotransmission as well as the release and effects of SP and SOM in nociception and other sensory processes...
  88. ncbi Differential expression of tetrodotoxin-resistant sodium channels Nav1.8 and Nav1.9 in normal and inflamed rats
    Richard E Coggeshall
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77555 1069, USA
    Neurosci Lett 355:45-8. 2004
    ..The massive increase in Nav1.8 expression in myelinated axons suggests that these may contribute to peripheral sensitization and inflammatory hyperalgesia...
  89. ncbi Differential modulation of nociceptive dural input to [hypocretin] orexin A and B receptor activation in the posterior hypothalamic area
    T Bartsch
    Headache Group, Institute of Neurology and National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
    Pain 109:367-78. 2004
    ....
  90. ncbi Differential sensitivity of thick and thin fibers to HIV and therapy-induced neuropathy
    Panagiotis Kokotis
    Academic Departments of Neurology Aeginition Hospital, Medical School of Athens, Athens, Greece
    Auton Neurosci 136:90-5. 2007
    The study assessed HIV-related and anti-retroviral therapy-induced neuropathy in myelinated and unmyelinated nerve fibers. One hundred consecutive HIV patients were examined clinically and standard nerve conduction velocities were ..
  91. ncbi Sex-related difference in collateral sprouting of nociceptive axons after peripheral nerve injury in the rat
    U Kovacic
    Institute of Pathophysiology, Medical Faculty, University of Ljubljana, Zalosbreve ka 4, 1000, Ljubljana, Slovenia
    Exp Neurol 184:479-88. 2003
    ..Therefore, the more extensive collateral axon sprouting observed in female than in male rats is probably due to the higher sprouting capacity of thin myelinated sensory axons in females...
  92. ncbi Effects of GCP-II inhibition on responses of dorsal horn neurones after inflammation and neuropathy: an electrophysiological study in the rat
    Katherine J Carpenter
    Department of Pharmacology, University College London, Gower Street, London, WC1E 6BT, UK
    Neuropeptides 37:298-306. 2003
    ..These results support an important role of endogenous NAAG in the spinal processing of noxious information...
  93. ncbi Localisation of cannabinoid receptor 1 in rat dorsal root ganglion using in situ hybridisation and immunohistochemistry
    D Bridges
    Pain Research, Department of Anaesthetics, Faculty of Medicine, Imperial College, Chelsea and Westminster Hospital Campus, London, UK
    Neuroscience 119:803-12. 2003
    ..These findings suggest that whilst a wide range of DRG neuron phenotypes express CB(1), it is predominantly associated with myelinated fibres...
  94. pmc Chemotherapy-evoked neuropathic pain: Abnormal spontaneous discharge in A-fiber and C-fiber primary afferent neurons and its suppression by acetyl-L-carnitine
    Wen Hua Xiao
    Department of Anesthesia, McGill University, 3655 Promenade Sir Wm Osler McIntyre Bldg, Room 1202, Montreal, Que, Canada H3G 1Y6
    Pain 135:262-70. 2008
    ....
  95. ncbi Paracrine-like excitation of low-threshold mechanoceptive C-fibers innervating rat hairy skin is mediated by substance P via NK-1 receptors
    Shi Hong Zhang
    Faculty of Pharmacology, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, PR China
    Brain Res Bull 75:138-45. 2008
    ..We propose that this cross-talk has evolved as a mechanism regulating the mechanoceptive characteristics of LTM C-fibers, presumably contributing to pain sensation elicited by tactile stimuli ('allodynia')...
  96. pmc Laminar organization of spinal dorsal horn neurones activated by C- vs. A-heat nociceptors and their descending control from the periaqueductal grey in the rat
    Stella Koutsikou
    Department of Physiology, School of Medical Sciences, University Walk, University of Bristol, UK
    Eur J Neurosci 26:943-52. 2007
    ..the deep dorsal horn and lateral spinal nucleus with respect to the processing of A- and C-fibre-evoked events. The data are discussed in relation to the roles of A- and C-nociceptors in acute and chronic pain...
  97. ncbi Somatosensory organization and behavior in naked mole-rats: II. Peripheral structures, innervation, and selective lack of neuropeptides associated with thermoregulation and pain
    Thomas J Park
    Department of Biological Sciences, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    J Comp Neurol 465:104-20. 2003
    ..The features of this mammalian model system provide unique opportunities to discriminate mechanisms related to tactile spatial orientation, vascular regulation, and nociception...
  98. ncbi Sensitization of rat dorsal horn neurons by NGF-induced subthreshold potentials and low-frequency activation. A study employing intracellular recordings in vivo
    Ulrich Hoheisel
    Institute of Pharmacology and Toxicology, Charite, Humboldt University, Dorotheenstrasse 94, D 10117 Berlin, Germany
    Brain Res 1169:34-43. 2007
    ..m. The data demonstrate that low-frequency activation or even subthreshold potentials in dorsal horn neurons evoked by unmyelinated muscle afferents are an effective means of sensitizing these neurons...
  99. ncbi Structure and function of bone marrow hemopoiesis: mechanisms of response to ionizing radiation exposure
    T M Fliedner
    Radiation Medicine Research Group and WHO Collaborating Center for Radiation Accident Management, University of Ulm, Helmholtzstrasse 20, 89081 Ulm, Germany
    Cancer Biother Radiopharm 17:405-26. 2002
    ..to recognize the significance of nerval regulation of blood flow, characterized by myelinated and unmyelinated nerve fibers. The type of unique lining cells of the sinusoids is the prerequisite for the cell traffic between the ..
  100. ncbi Facial arthralgia and myalgia: can they be differentiated by trigeminal sensory assessment?
    Eli Eliav
    Department of Oral Diagnosis Oral Medicine and Radiology, Hadassah Faculty of Dental Medicine, The Hebrew University, P O Box 12272, Jerusalem 91120, Israel
    Pain 104:481-90. 2003
    ..assess thresholds in large myelinated nerve fibers (Abeta) and heat application to assess thresholds in unmyelinated nerve fibers (C)...
  101. ncbi Innervation of blood vessels in the rat incisor pulp: a scanning electron microscopic and immunoelectron microscopic study
    S Tabata
    Department of Animal Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Anat Rec 251:384-91. 1998
    ..5 antibody. SEM specimens revealed that unmyelinated nerve fibers passed through the tunica adventitia of the blood vessel in the center of the pulp and that these fibers ..

Research Grants51

  1. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010
    ..determine the relationship between a decrease in tactile sensitivity and innervation by myelinated and unmyelinated nerve fibers in the finger pad...
  2. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  3. PULMONARY C-NEURON HYPERSENSITIVITY:CELLULAR MECHANISMS
    Lu Yuan Lee; Fiscal Year: 2005
    ..This information may, therefore, help to develop new therapeutic strategies for alleviating the symptoms of bronchial hyperreactivity associated with airway mucosal inflammation. ..
  4. Chemosensitivity of Tachykinin-containing Lung Afferents
    Lu Yuan Lee; Fiscal Year: 2008
    ..The results obtained from this study should provide critical information for gaining new insights into the mechanisms underlying the airway hyperresponsiveness induced by cationic proteins. [unreadable] [unreadable]..
  5. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  6. Role of TRPV1 in Airway Hypersensitivity Induced by Inflammation
    Lu Yuan Lee; Fiscal Year: 2010
    ..The results obtained from these studies should bring a new insight into the pathogenesis and therapeutic strategy for alleviating the airway hypersensitivity. ..
  7. MAST CELL NERVE INTERACTIONS IN AIRWAYS
    Bradley J Undem; Fiscal Year: 2010
    ..The results may also shed new light on the complex pathophysiology of allergic airway diseases, i.e., asthma, and ultimately suggest new therapeutic strategies for treatment of these complex disorders. ..
  8. CEREBELLUM--ROLE IN THE CHEMICAL CONTROL OF BREATHING
    Fadi Xu; Fiscal Year: 2003
    ..Perhaps, more exciting is the emerging concept that the cerebellum may be far more involved in the planning and executing of motor responses, including respiration, than we have heretofore imagined. ..
  9. Central Mechanisms of Respiratory Arrest
    Fadi Xu; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  10. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  11. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  12. ENDOCANNABINOID ANALGESIA: AN IN VIVO GENE TRANSFER - LIPIDOMICS APPROACH
    Andrea Hohmann; Fiscal Year: 2007
    ..Successful validation of our technological approach and hypotheses may facilitate development of endocannabinoid-based pharmacological and gene therapies for pain. [unreadable] [unreadable] [unreadable]..
  13. Mechanisms of Neural Mobilization for Chronic Pain
    STEVEN GEORGE; Fiscal Year: 2007
    ..These data may also provide support for a future clinical trial investigating the efficacy of median nerve NMT for patients with CTS. [unreadable] [unreadable] [unreadable]..
  14. Sodium Channel Expression in Human Teeth
    Michael Henry; Fiscal Year: 2009
    ..abstract_text> ..
  15. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  16. DIABETIC NEUROPATHY STUDY
    PETER DYCK; Fiscal Year: 2008
    ..abstract_text> ..
  17. Migraine headache and central pain facilitating systems
    Mary M Heinricher; Fiscal Year: 2010
    ..This idea is attractive because a central dysfunction could potentially explain the multiple triggers for migraine attached, as well as the range of associated symptoms, including nausea and aversion to light and sound. ..
  18. Diffusion Tensor Imaging of White Matter Change in AD
    David Salat; Fiscal Year: 2008
    ..Thus, the proposed integrated training and research program could lead to novel insights about the unique contribution of WM degeneration to the clinical sequel of AD. ..
  19. Supraspinal prostaglandins and descending control
    Mary Heinricher; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  20. AN ENDOCANNABINOID MECHANISM FOR STRESS-INDUCED ANALGESIA
    ANDREA GRACE HOHMANN; Fiscal Year: 2010
    ..Furthermore, the results will provide essential information on the mechanisms responsible for endocannabinoid deactivation in the brain, which may facilitate the development of novel analgesic and anti- stress medicines. ..
  21. Spinal Opioid Release in Nociception
    Juan Carlos Marvizon; Fiscal Year: 2008
    ..The neural pathways involved will be studied using selective spinal cord lesions. ..
  22. Remark bundle structure and function in neuropathic pain
    John W Griffin; Fiscal Year: 2010
    ..The proposed data will have implications for understanding and treating not just pain in partial nerve injuries, but painful neuropathies such as diabetes, causalgia, and postherpetic neuralgia. ..
  23. Neural circuitry of improgran analgesia
    Mary M Heinricher; Fiscal Year: 2010
    ....
  24. Presynaptic Mechanisms of Neurotransmission in NTS
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..The different sub classes of afferent nerve terminal will be also be compared in terms of their control of glutamate release and modulation by peptides. ..
  25. Post-natal neurogenesis in the turtle spinal cord
    RAUL RUSSO; Fiscal Year: 2009
    ..This knowledge is essential to understand basic neurogenic mechanisms that may remain "dormant" in the mammalian spinal cord but could hopefully be "awakened" to alleviate spinal cord diseases. ..
  26. 2007 International Peripheral Nerve Society Meeting at Snowbird, Utah
    A Smith; Fiscal Year: 2007
    ..The meeting directly impacts public health and patient care by disseminating important new ideas (both research and therapeutic) and by developing consensus guidelines. [unreadable] [unreadable] [unreadable]..
  27. Neuromaging of nicotine withdrawal
    Jody Tanabe; Fiscal Year: 2007
    ..acute nicotine withdrawal in smokers? ii) Does acute nicotine withdrawal involve dopaminergic system or non-dopaminergic regions? iii) Does nicotine replacement reverse the alterations in CBF during nicotine withdrawal? ..
  28. Role of vagal nerves in hyperpnea
    Jerry Yu; Fiscal Year: 2006
    ..The information gained will improve our understanding of neural control of breathing, leading to better clinical management of pulmonary problems. ..
  29. Multimodal MRI and spectroscopy of irradiated brain
    Michael Lee; Fiscal Year: 2006
    ..This will allow clinicians and researchers to better understand patterns of failure following radiotherapy of high grade gliomas, and adjust accordingly. ..
  30. HUMAN AXONAL REGENERATION IN DIABETIC NEUROPATHY
    Michael Polydefkis; Fiscal Year: 2005
    ..Polydefkis the skills he needs to develop into an independent clinician researcher in the field of peripheral nerve disease. ..
  31. Interleukin-1Beta in Central Pain Modulating Circuits
    Mary Heinricher; Fiscal Year: 2004
    ..In providing additional tools to manipulate these systems, this work may ultimately lead to improved clinical treatment of pain. ..
  32. MACROPHAGE RECRUITMENT IN NERVOUS SYSTEM INJURY & REPAIR
    John Griffin; Fiscal Year: 2001
    ..Such animals will provide the ideal system in which to test the possibility that CNS regeneration will be substantially improved by permitting macrophage recruitment. ..
  33. Modulatory Effect of Acupuncture on Human Brain Activity
    Kathleen Hui; Fiscal Year: 2003
    ..abstract_text> ..
  34. A THERMAL PROBE METHOD FOR STAGING DIABETIC NEUROPATHY
    William Kennedy; Fiscal Year: 2002
    ..abstract_text> ..
  35. Medullary Circuitry of Opioid Analgesia
    Mary Heinricher; Fiscal Year: 2006
    ..The proposed work should advance our understanding of central processes involved in bi-directional pain modulation, and should ultimately lead to improved clinical treatment of pain. ..
  36. Trigeminal Neuropathic Pain Mechanisms
    Michael Henry; Fiscal Year: 2006
    ..Identification of specific sodium channel alterations after injury may help develop more selective treatments for neuropathic pain. ..
  37. Behavioral Interventions for Low Back Pain
    STEVEN GEORGE; Fiscal Year: 2007
    ....
  38. Predicting progression of NeuroAIDS
    Justin McArthur; Fiscal Year: 2007
    ..Abstract Not Provided: ..
  39. Activation of Cutaneous Mechanoreceptors by Shear Stress
    Peter Grigg; Fiscal Year: 2007
    ..In this proposal we propose to dynamically manipulate shear stress, and measure shear strain, in an attempt to determine whether activation of afferent neurons is caused by shear or normal components of stress or strain. ..
  40. Peripheral neurotoxicity by the HIV-1 coat protein gp120
    Ahmet Hoke; Fiscal Year: 2007
    ..A major strength of our proposal is our use of human tissues to study a disease that only affects humans. ..
  41. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  42. PERIPHERAL CANNABINOID MODULATION OF PAIN TRANSMISSION
    Andrea Hohmann; Fiscal Year: 2005
    ..abstract_text> ..
  43. HIV-sensory neuropathies:risk factors, immunopathology
    Justin McArthur; Fiscal Year: 2006
    ..We will extend our studies of the immunopathology of HIV-SN, using our extensive tissue collections to define the relationship of chemokine upregulation to neuropathic pain. ..
  44. METHODS TO DIAGNOSE AND EVALUATE THERAPY FOR DIABETES
    William Kennedy; Fiscal Year: 2001
    ..If NGF can enhance reinnervation in the skin wound these methods may be useful to evaluate the results of clinical therapeutic trials. ..
  45. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2006
    ..By examining different anesthetics, we may also better understand whether potentially new anesthetics might be designed to spare these cardioregulatory sites. [unreadable] [unreadable]..
  46. Neural blockade with vanilloids
    Igor Kissin; Fiscal Year: 2007
    ..To study the specific aims of the project the effects of RTX will be examined in rats by behavioral methods; and whole cell voltage-clamp technique will be used to identify a mechanism for impulse failure induced by RTX. ..
  47. ACUTE TOLERANCE IN ANESTHETIC ACTIONS AND INTERACTIONS
    Igor Kissin; Fiscal Year: 2001
    ....
  48. Respiratory activities of intrinsic tongue muscles
    E Bailey; Fiscal Year: 2004
    ....
  49. Transmission Across the First Synapse of the Baroreflex
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..These Aims will provide new and direct information about NTS that leads to a better understanding of the normal basis of the neural control of the circulation as pathophysiology. ..