nerve fibers

Summary

Summary: Slender processes of NEURONS, including the AXONS and their glial envelopes (MYELIN SHEATH). Nerve fibers conduct nerve impulses to and from the central nervous system.

Top Publications

  1. ncbi Integration of quanta in cerebellar granule cells during sensory processing
    Paul Chadderton
    Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 428:856-60. 2004
  2. ncbi Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Brain 130:630-53. 2007
  3. ncbi Fiber tract-based atlas of human white matter anatomy
    Setsu Wakana
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 217 Traylor Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Radiology 230:77-87. 2004
  4. ncbi Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis
    Jennifer B Fisher
    Division of Neuro ophthalmology, Departments of Neurology, Ophthalmology, and Biostatistics, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania, USA
    Ophthalmology 113:324-32. 2006
  5. pmc Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
    Lauren S Talman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 67:749-60. 2010
  6. ncbi Microstructural maturation of the human brain from childhood to adulthood
    C LeBel
    Department of Biomedical Engineering, Faculty of Medicine and Dentistry, Room 1098 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada T6G 2V2
    Neuroimage 40:1044-55. 2008
  7. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
  8. ncbi Multiple climbing fibers signal to molecular layer interneurons exclusively via glutamate spillover
    German Szapiro
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS, 46 rue d Ulm, 75005 Paris, France
    Nat Neurosci 10:735-42. 2007
  9. pmc Retinal thickness decreases with age: an OCT study
    B Alamouti
    University of Freiburg Eye Hospital, Germany
    Br J Ophthalmol 87:899-901. 2003
  10. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008

Detail Information

Publications306 found, 100 shown here

  1. ncbi Integration of quanta in cerebellar granule cells during sensory processing
    Paul Chadderton
    Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 428:856-60. 2004
    ..Granule cell bursts are optimally suited to trigger glutamate receptor activation and plasticity at parallel fibre synapses, providing a link between input representation and memory storage in the cerebellum...
  2. ncbi Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Brain 130:630-53. 2007
    ..By replicating the major features of these tracts identified by histological techniques in monkey, we show that DSI has the potential to cast new light on the organization of the human brain in the normal state and in clinical disorders...
  3. ncbi Fiber tract-based atlas of human white matter anatomy
    Setsu Wakana
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 217 Traylor Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Radiology 230:77-87. 2004
    ..which anatomic structures can be identified on diffusion tensor images and (b). where these anatomic units are located at each section level and orientation. The atlas may prove useful for educational and clinical purposes...
  4. ncbi Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis
    Jennifer B Fisher
    Division of Neuro ophthalmology, Departments of Neurology, Ophthalmology, and Biostatistics, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, Pennsylvania, USA
    Ophthalmology 113:324-32. 2006
    ....
  5. pmc Longitudinal study of vision and retinal nerve fiber layer thickness in multiple sclerosis
    Lauren S Talman
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Ann Neurol 67:749-60. 2010
    ..We determined how longitudinal changes in RNFL thickness relate to visual loss. We also examined patterns of RNFL thinning over time in MS eyes with and without a prior history of acute optic neuritis (ON)...
  6. ncbi Microstructural maturation of the human brain from childhood to adulthood
    C LeBel
    Department of Biomedical Engineering, Faculty of Medicine and Dentistry, Room 1098 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada T6G 2V2
    Neuroimage 40:1044-55. 2008
    ..These in vivo results expand upon previous postmortem and imaging studies and provide quantitative measures indicative of the progression and magnitude of regional human brain maturation...
  7. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
    ....
  8. ncbi Multiple climbing fibers signal to molecular layer interneurons exclusively via glutamate spillover
    German Szapiro
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS, 46 rue d Ulm, 75005 Paris, France
    Nat Neurosci 10:735-42. 2007
    ..Climbing fibers are known to direct parallel fiber synaptic plasticity in interneurons, so one function of this spillover is likely to involve controlling synaptic plasticity...
  9. pmc Retinal thickness decreases with age: an OCT study
    B Alamouti
    University of Freiburg Eye Hospital, Germany
    Br J Ophthalmol 87:899-901. 2003
    ..The aim of the study was to check this hypothesis using optical coherence tomography, and additionally to determine the reproducibility of OCT measurements in this area...
  10. ncbi An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography
    Andrew P D Henderson
    NMR Research Unit, Institute of Neurology, University College London, London, WC1N 3BG, UK
    Brain 131:277-87. 2008
    ..This may indicate a difference in the extent of the pathological processes that cause axonal loss in the retina, and by inference the optic nerve, in secondary progressive MS and primary progressive MS...
  11. ncbi EFNS guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy
    G Lauria
    Immunology and Muscular Pathology Unit, Department of Clinical Neurosciences, National Neurological Institute Carlo Besta, Milan, Italy
    Eur J Neurol 12:747-58. 2005
    ..Training in an established cutaneous nerve laboratory is recommended before using skin biopsy as a diagnostic tool in peripheral neuropathies. Quality control at all levels is mandatory...
  12. ncbi Relationship between retinal nerve fiber layer measurement and signal strength in optical coherence tomography
    Carol Yim Lui Cheung
    Department of Ophthalmology and Visual Sciences, Chinese University of Hong Kong, Hong Kong, China
    Ophthalmology 115:1347-51, 1351.e1-2. 2008
    ..To examine the relationship between signal strength and retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT)...
  13. ncbi Reproducibility of retinal nerve fiber thickness measurements using the stratus OCT in normal and glaucomatous eyes
    Donald L Budenz
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami School of Medicine, Miami, Florida 33136, USA
    Invest Ophthalmol Vis Sci 46:2440-3. 2005
    ..To determine the reproducibility of Stratus Optical Coherence Tomography (OCT) retinal nerve fiber layer (RNFL) measurements around the optic nerve in normal and glaucomatous eyes...
  14. ncbi Molecular, topographic, and functional organization of the cerebellar cortex: a study with combined aldolase C and olivocerebellar labeling
    Izumi Sugihara
    Department of Systems Neurophysiology, Tokyo Medical and Dental University, Graduate School of Medicine, Tokyo 113 8519, Japan
    J Neurosci 24:8771-85. 2004
    ..Thus, the five-group scheme we propose here may integrate the molecular, topographic, and functional organization of the cerebellum...
  15. pmc Neurovascular invasion at the osteochondral junction and in osteophytes in osteoarthritis
    Sunita Suri
    Academic Rheumatology, University of Nottingham, City Hospital, Hucknall Road, Nottingham, Notts NG5 1PB, UK
    Ann Rheum Dis 66:1423-8. 2007
    ..Normal adult articular cartilage is thought to be avascular and aneural...
  16. ncbi The spectrum of neuropathy in diabetes and impaired glucose tolerance
    C J Sumner
    Department of Neurology, The Johns Hopkins University, Baltimore, MD, USA
    Neurology 60:108-11. 2003
    ..To compare the neuropathy associated with impaired glucose tolerance (IGT) and diabetes mellitus (DM) determined by oral glucose tolerance testing (OGTT)...
  17. pmc Longitudinal change detected by spectral domain optical coherence tomography in the optic nerve head and peripapillary retina in experimental glaucoma
    Nicholas G Strouthidis
    Optic Nerve Head Research Laboratory, Devers Eye Institute, Legacy Health System, Portland, OR 97208 3950, USA
    Invest Ophthalmol Vis Sci 52:1206-19. 2011
    ....
  18. pmc Impaired sprouting and axonal atrophy in cerebellar climbing fibres following in vivo silencing of the growth-associated protein GAP-43
    Giorgio Grasselli
    Santa Lucia Foundation IRCCS, Rome, Italy
    PLoS ONE 6:e20791. 2011
    ..Collectively, our results demonstrate that GAP-43 is essential both to maintain CFs structure in non-traumatic condition and to promote sprouting after partial lesion of the IO...
  19. ncbi Correlation between morphological and functional retinal impairment in multiple sclerosis patients
    V Parisi
    Cattedra di Clinica Oculistica, Universita di Roma Tor Vergata, Italy
    Invest Ophthalmol Vis Sci 40:2520-7. 1999
    ..To assess whether a correlation exists between optic nerve fiber layer (NFL) thickness and the retinal or visual pathway function in multiple sclerosis (MS) patients previously affected by optic neuritis...
  20. pmc Association of retinal and macular damage with brain atrophy in multiple sclerosis
    Jan Dorr
    NeuroCure Clinical Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e18132. 2011
    ..Whereas BPF best reflects disease severity, RNFLT might be the better parameter for monitoring axonal damage longitudinally. Longitudinal studies are necessary for validation of data and to further clarify the relevance of TMV...
  21. ncbi Lifestyle intervention for pre-diabetic neuropathy
    A Gordon Smith
    Department of Neurology, University of Utah School of Medicine, 50 N Medical Drive, SOM 3R152, Salt Lake City, UT 84132, USA
    Diabetes Care 29:1294-9. 2006
    ....
  22. ncbi Calcium transients evoked by climbing fiber and parallel fiber synaptic inputs in guinea pig cerebellar Purkinje neurons
    H Miyakawa
    Department of Physiology, New York Medical College, Valhalla 10595
    J Neurophysiol 68:1178-89. 1992
    ..This effect could be modulated by changes in the resting potential, suggesting that the same intrinsic mechanism was affecting the spread of both CF and PF signals...
  23. ncbi Precise spatial relationships between mossy fibers and climbing fibers in rat cerebellar cortical zones
    Angelique Pijpers
    Department of Neuroscience, Erasmus Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Neurosci 26:12067-80. 2006
    ..Together with the distribution of neurons in precerebellar centers, the findings suggest a revision of the modular hypothesis for information processing in the cerebellar cortex...
  24. pmc Comparison of retinal nerve fiber layer measurements using time domain and spectral domain optical coherent tomography
    O Rese J Knight
    Bascom Palmer Eye Institute, Department of Ophthalmology, Miller School of Medicine, University of Miami, Miami 33136, Florida, USA
    Ophthalmology 116:1271-7. 2009
    ....
  25. ncbi Comparison of macular and peripapillary measurements for the detection of glaucoma: an optical coherence tomography study
    Christopher K S Leung
    Department of Ophthalmology, Caritas Medical Centre, Hong Kong, China
    Ophthalmology 112:391-400. 2005
    ....
  26. ncbi Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects
    Carol Y Cheung
    Singapore Eye Research Institute, Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 52:9629-35. 2011
    ..To evaluate the ocular and systemic factors influencing measurements of optic nerve head (ONH) parameters and retinal nerve fiber layer (RNFL) thickness with spectral-domain optical coherence tomography (SD-OCT) in healthy Chinese adults...
  27. pmc A framework for comparing structural and functional measures of glaucomatous damage
    Donald C Hood
    Department of Psychology, Columbia University, 116th and Broadway, New York, NY, 10027 7004, USA
    Prog Retin Eye Res 26:688-710. 2007
    ....
  28. ncbi Spatial pattern coding of sensory information by climbing fiber-evoked calcium signals in networks of neighboring cerebellar Purkinje cells
    Simon R Schultz
    Department of Bioengineering, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    J Neurosci 29:8005-15. 2009
    ..The olivocerebellar circuit thus uses a labeled line code to report sensory signals, leaving open a role for synchrony in flexible selection of signals for output to deep cerebellar nuclei...
  29. pmc Blockade of nerve sprouting and neuroma formation markedly attenuates the development of late stage cancer pain
    W G Mantyh
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 85724, USA
    Neuroscience 171:588-98. 2010
    ..as tumor growth progresses within bone, tropomyosin receptor kinase A (TrkA)-expressing sensory and sympathetic nerve fibers undergo profuse sprouting and form neuroma-like structures...
  30. pmc Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness
    G Vizzeri
    Hamilton Glaucoma Center, Department of Ophthalmology, University of California San Diego, La Jolla, CA, USA
    Br J Ophthalmol 93:775-81. 2009
    ..To evaluate spectral-domain (SD) optical coherence tomography (OCT) reproducibility and assess the agreement between SD-OCT and Time-Domain (TD) OCT retinal nerve fibre layer (RNFL) measurements...
  31. ncbi The distribution of climbing and mossy fiber collateral branches from the copula pyramidis and the paramedian lobule: congruence of climbing fiber cortical zones and the pattern of zebrin banding within the rat cerebellum
    Jan Voogd
    Department of Physiology, University of Bristol, BS8 1TD Bristol, United Kingdom
    J Neurosci 23:4645-56. 2003
    ..Overall, these results suggest that climbing fiber zones and zebrin banding reflect a common organizational scheme within the cerebellar cortex...
  32. ncbi Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study
    Giuseppe Lauria
    Neuromuscular Diseases Unit, IRCCS Foundation Carlo Besta Neurological Institute, Milan, Italy
    J Peripher Nerv Syst 15:202-7. 2010
    ..002). Height, weight, or BMI did not influence the calculated 5th percentile IENF normative densities in both genders. Our study provides IENF density normative reference values at the distal leg to be used in clinical practice...
  33. ncbi The spatial organization of long-term synaptic plasticity at the input stage of cerebellum
    Jonathan Mapelli
    Department of Cellular and Molecular Physiological and Pharmacological Sciences, University of Pavia and National Institute for the Physics of Matter, I 27100 Pavia, Italy
    J Neurosci 27:1285-96. 2007
    ..2005). By this mechanism, LTP and LTD could regulate the geometry and contrast of network computations, preprocessing the mossy fiber input to be conveyed to Purkinje cells and molecular layer interneurons...
  34. ncbi The LDIflare: a novel test of C-fiber function demonstrates early neuropathy in type 2 diabetes
    Singhan T M Krishnan
    FRCP, The Ipswich Diabetes Centre, Ipswich Hospital NHS Trust, Heath Road, Ipswich, UK
    Diabetes Care 27:2930-5. 2004
    ..The aim of this study was to evaluate a novel method for assessing the axon reflex and to determine its value in detecting neuropathy in type 2 diabetes...
  35. ncbi Early onset of spontaneous activity in uninjured C-fiber nociceptors after injury to neighboring nerve fibers
    G Wu
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 21:RC140. 2001
    ..Because L4 afferents comingle with degenerating L5 axons in the peripheral nerve, we hypothesize that products associated with Wallerian degeneration lead to an alteration in the properties of the adjacent, uninjured afferents...
  36. ncbi Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity
    A Apostolidis
    Peripheral Neuropathy Unit, Hammersmith Hospital, Imperial College London, United Kingdom
    J Urol 174:977-82; discussion 982-3. 2005
    ..We investigated a possible effect of BoNT/A on human bladder afferent mechanisms by studying the sensory receptors P2X3 and TRPV1 in biopsies from patients with neurogenic or idiopathic DO...
  37. pmc Reproducibility of nerve fiber thickness, macular thickness, and optic nerve head measurements using StratusOCT
    Lelia A Paunescu
    New England Eye Center, Boston, Massachusetts, USA
    Invest Ophthalmol Vis Sci 45:1716-24. 2004
    ..A2, Carl Zeiss Meditec Inc., Dublin, CA) was investigated. The nerve fiber layer (NFL) thickness, macula thickness map, and optic nerve head (ONH) parameters in normal eyes were studied...
  38. ncbi Morphologic changes and functional retinal impairment in patients with Parkinson disease without visual loss
    Marilita M Moschos
    Department of Ophthalmology, University of Athens, Athens, Greece
    Eur J Ophthalmol 21:24-9. 2011
    ..To investigate the anatomic and electrophysiologic changes of the macula and the optic nerve in patients with Parkinson disease (PD) without visual impairment...
  39. ncbi Retinal nerve fiber layer thinning in Parkinson disease
    Rivka Inzelberg
    Department of Neurology, Hillel Yaffe Medical Center, Hadera 38100, Israel
    Vision Res 44:2793-7. 2004
    ..002), while the inferotemporal area was the thinnest (146 +/- 24 vs. 191 +/- 21 microns; p=0.0003). The results show significant loss of RNFL thickness in PD at specific sites...
  40. pmc Three-dimensional retinal imaging with high-speed ultrahigh-resolution optical coherence tomography
    Maciej Wojtkowski
    Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ophthalmology 112:1734-46. 2005
    ..To demonstrate high-speed, ultrahigh-resolution, 3-dimensional optical coherence tomography (3D OCT) and new protocols for retinal imaging...
  41. ncbi Optical coherence tomography and disease subtype in multiple sclerosis
    M Pulicken
    Department of Neurology, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
    Neurology 69:2085-92. 2007
    ..To examine retinal nerve fiber layer (RNFL) thickness, macular volumes (MV), and visual acuity in multiple sclerosis (MS) eyes, with and without history of acute optic neuritis (ON)...
  42. pmc Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma
    Gadi Wollstein
    New England Eye Center, Tufts New England Medical Center, Tufts University School of Medicine, Boston, Mass, USA
    Arch Ophthalmol 123:464-70. 2005
    ..To longitudinally evaluate optical coherence tomography (OCT) peripapillary retinal nerve fiber layer thickness measurements and to compare these measurements across time with clinical status and automated perimetry...
  43. ncbi Quantitative diffusion tensor imaging in cerebral palsy due to periventricular white matter injury
    Bejoy Thomas
    Department of Radiology, University Hospitals, KUL, Leuven, Belgium
    Brain 128:2562-77. 2005
    ..Also evidence suggesting the reorganization of sensorimotor tracts in the unaffected side of spastic hemiparetic patients was noted...
  44. ncbi Inner retinal layer thinning in Parkinson disease
    Mohammedyusuf E Hajee
    Department of Neurology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
    Arch Ophthalmol 127:737-41. 2009
    ..To quantify retinal thickness in patients with Parkinson disease (PD)...
  45. ncbi Retinal nerve fiber layer evaluation by optical coherence tomography in Leber's hereditary optic neuropathy
    Piero Barboni
    Centro di Oftalmologia Salus, Bologna, Italy
    Ophthalmology 112:120-6. 2005
    ..To study retinal nerve fiber layer (RNFL) thickness by optical coherence tomography (StratusOCT) in patients with Leber's hereditary optic neuropathy (LHON)...
  46. ncbi The utility of skin biopsy for prediction of progression in suspected small fiber neuropathy
    C H Gibbons
    Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Neurology 66:256-8. 2006
    ..Patients without nerve fiber swellings did not have changes in nerve fiber density between biopsies. Patients with large nerve fiber swellings were most likely to present clinically with paresthesias (p < 0.05)...
  47. ncbi Quantification of the retinal nerve fibre layer thickness in normal Indian eyes with optical coherence tomography
    Parul Sony
    Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India
    Indian J Ophthalmol 52:303-9. 2004
    ..To quantitatively assess the normative values for peripapillary retinal nerve fibre layer (RNFL) thickness with Optical Coherence Tomography (OCT 3) in Indian subjects...
  48. ncbi Natural history of Leber's hereditary optic neuropathy: longitudinal analysis of the retinal nerve fiber layer by optical coherence tomography
    Piero Barboni
    Studio Oculistico d Azeglio, Bologna, Italy
    Ophthalmology 117:623-7. 2010
    ....
  49. ncbi Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses
    Gen Ohtsuki
    Department of Biophysics, Graduate School of Science, Kyoto University, Sakyo ku, Kyoto 606 8502, Japan
    Eur J Neurosci 28:2393-400. 2008
    ..These results reveal the existence of novel presynaptic plasticity at immature climbing fiber-Purkinje cell synapses, which may contribute to the maturation and refinement of the climbing fiber projection pattern...
  50. pmc Auditory nerve fibers excite targets through synapses that vary in convergence, strength, and short-term plasticity
    Xiao Jie Cao
    Department of Physiology, School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Neurophysiol 104:2308-20. 2010
    Auditory nerve fibers are the major source of excitation to the three groups of principal cells of the ventral cochlear nucleus (VCN), bushy, T stellate, and octopus cells...
  51. ncbi Developmental switching of perisomatic innervation from climbing fibers to basket cell fibers in cerebellar Purkinje cells
    Ryoichi Ichikawa
    Department of Anatomy, School of Medicine, Sapporo Medical University, Sapporo 060 8556, Japan
    J Neurosci 31:16916-27. 2011
    ....
  52. pmc Glaucomatous damage of the macula
    Donald C Hood
    Department of Psychology, Columbia University, New York, NY 10027 7004, USA
    Prog Retin Eye Res 32:1-21. 2013
    ....
  53. pmc Optic nerve head and retinal nerve fiber layer analysis: a report by the American Academy of Ophthalmology
    Shan C Lin
    Ophthalmology 114:1937-49. 2007
    ..To evaluate the current published literature on the use of optic nerve head (ONH) and retinal nerve fiber layer (RNFL) measurement devices in diagnosing open-angle glaucoma and detecting progression...
  54. ncbi Altered olivocerebellar activity patterns in the connexin36 knockout mouse
    Sarah P Marshall
    Department of Physiology and Neuroscience, New York University, School of Medicine, New York, USA
    Cerebellum 6:287-99. 2007
    ..Thus, the differences in CS activity between Wts and Cx36KOs likely reflect the loss of electrical coupling of IO cells...
  55. ncbi Parasagittal compartmentation of cerebellar mossy fibers as revealed by the patterned expression of vesicular glutamate transporters VGLUT1 and VGLUT2
    Samrawit A Gebre
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Yeshiva University, Bronx, NY 10461, USA
    Brain Struct Funct 217:165-80. 2012
    ....
  56. pmc Early loss of peptidergic intraepidermal nerve fibers in an STZ-induced mouse model of insensate diabetic neuropathy
    Megan S Johnson
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Pain 140:35-47. 2008
    ..5 staining, nonpeptidergic (PGP+/GFP+) and peptidergic (PGP+/GFP-) intraepidermal nerve fibers (IENFs) were quantified at each time point...
  57. ncbi Small fibers in Fabry disease: baseline and follow-up data under enzyme replacement therapy
    Nurcan Uceyler
    Department of Neurology, University of Wurzburg, Wurzburg, Germany
    J Peripher Nerv Syst 16:304-14. 2011
    ..lysosomal storage disorder which may lead to impaired peripheral nerve function, mostly affecting small nerve fibers, and to neuropathic pain...
  58. pmc Hybrid diffusion imaging
    Yu Chien Wu
    Department of Radiology, University of Wisconsin Madison, Madison, WI, USA
    Neuroimage 36:617-29. 2007
    ..In this study, an HYDI encoding scheme with 102 diffusion-weighted measurements was obtained over most of the human cerebrum in under 30 min...
  59. pmc Ability of cirrus HD-OCT optic nerve head parameters to discriminate normal from glaucomatous eyes
    Jean Claude Mwanza
    Bascom Palmer Eye Institute, Miami Miller School of Medicine, University of Miami, Miami, Florida 33136, USA
    Ophthalmology 118:241-8.e1. 2011
    ..Dublin, CA) to discriminate between normal and glaucomatous eyes and to compare them with the discriminating ability of peripapillary retinal nerve fiber layer (RNFL) thickness measurements performed with Cirrus HD-OCT...
  60. ncbi Detection of glaucoma progression by assessment of segmented macular thickness data obtained using spectral domain optical coherence tomography
    Jung Hwa Na
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Invest Ophthalmol Vis Sci 53:3817-26. 2012
    ....
  61. ncbi Influence of parallel fiber-Purkinje cell synapse formation on postnatal development of climbing fiber-Purkinje cell synapses in the cerebellum
    K Hashimoto
    Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuroscience 162:601-11. 2009
    ..Normal PF-PC synapse formation is required for the "late phase" of CF synapse elimination...
  62. ncbi Progression detection capability of macular thickness in advanced glaucomatous eyes
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 119:308-13. 2012
    ..To evaluate the progression rate of macular and circumpapillary retinal nerve fiber layer (RNFL) thickness in advanced glaucomatous eyes using spectral domain optical coherence tomography (Cirrus HD-OCT, Carl Zeiss Meditec, Dublin, CA)...
  63. pmc Imaging retinal nerve fiber bundles using optical coherence tomography with adaptive optics
    Omer P Kocaoglu
    School of Optometry, Indiana University, 800 E Atwater Avenue, Bloomington, IN 47405, United States
    Vision Res 51:1835-44. 2011
    ..0μm (width) and 0.3±1.5μm (thickness). UHR-AO-OCT outperformed commercial OCT in terms of clarity of the microscopic retina. To our knowledge, these are the first measurements of RNFB cross section reported in the living human eye...
  64. ncbi Cirrus high-definition optical coherence tomography compared with Stratus optical coherence tomography in glaucoma diagnosis
    Javier Moreno-Montañés
    Department of Ophthalmology, Clinica Universidad de Navarra, Pamplona, Spain
    Invest Ophthalmol Vis Sci 51:335-43. 2010
    ..To compare the retinal nerve fiber layer (RNFL) evaluation using Cirrus optical coherence tomography (OCT) and Stratus OCT in glaucoma diagnosis...
  65. pmc Temporal retinal nerve fiber loss in patients with spinocerebellar ataxia type 1
    Sarah Stricker
    Klinik fur Neurologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e23024. 2011
    ..Beyond brain atrophy, few data exist concerning retinal and optic nerve involvement...
  66. ncbi Sensitivity and specificity of time-domain versus spectral-domain optical coherence tomography in diagnosing early to moderate glaucoma
    Robert T Chang
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmology 116:2294-9. 2009
    ....
  67. ncbi Evaluation of retinal nerve fiber layer progression in glaucoma: a study on optical coherence tomography guided progression analysis
    Christopher Kai Shun Leung
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, People s Republic of China
    Invest Ophthalmol Vis Sci 51:217-22. 2010
    ..To evaluate optical coherence tomography (OCT) retinal nerve fiber layer thickness (RNFLT) measurement for glaucoma progression analysis...
  68. ncbi Retinal nerve fiber layer thickness in normals measured by spectral domain OCT
    Delia Bendschneider
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    J Glaucoma 19:475-82. 2010
    ....
  69. ncbi Organization and remodeling of the olivocerebellar climbing fiber projection
    Izumi Sugihara
    Department of Systems Neurophysiology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan
    Cerebellum 5:15-22. 2006
    ..The decrease in climbing fibers in the same and following periods is correlated with the elimination of overabundant synapses to establish one-to-one connections...
  70. ncbi Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease
    H N Noristani
    Faculty of Life Sciences, The University of Manchester, Manchester, UK
    Eur J Neurosci 32:71-9. 2010
    ....
  71. ncbi Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography
    Felipe A Medeiros
    Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, California 92093 0946, USA
    Am J Ophthalmol 139:44-55. 2005
    ..To compare the ability of optical coherence tomography retinal nerve fiber layer (RNFL), optic nerve head, and macular thickness parameters to differentiate between healthy eyes and eyes with glaucomatous visual field loss...
  72. ncbi Increased cannabinoid receptor 1-immunoreactive nerve fibers in overactive and painful bladder disorders and their correlation with symptoms
    Gaurav Mukerji
    Peripheral Neuropathy Unit, Hammersmith Hospital and Imperial College, London, United Kingdom
    Urology 75:1514.e15-20. 2010
    ....
  73. pmc GluRdelta2 expression in the mature cerebellum of hotfoot mice promotes parallel fiber synaptogenesis and axonal competition
    Georgia Mandolesi
    EBRI Santa Lucia Foundation IRCCS, Rome, Italy
    PLoS ONE 4:e5243. 2009
    ..Collectively, our observations show that GluRdelta2 is an adhesion molecule that induces the formation of PF contacts independently of its cellular localization and promotes heterosynaptic competition in the PC proximal dendritic domain...
  74. pmc Metabolic changes in the visual cortex are linked to retinal nerve fiber layer thinning in multiple sclerosis
    Caspar F Pfueller
    NeuroCure Clinical Research Center, Charite Universitaetsmedizin Berlin, Berlin, Germany
    PLoS ONE 6:e18019. 2011
    ....
  75. ncbi Homosynaptic long-term synaptic potentiation of the "winner" climbing fiber synapse in developing Purkinje cells
    Laurens W J Bosman
    Institute of Neuroscience and Center of Integrated Protein Science, Technical University Munich, 80802 Munich, Germany
    J Neurosci 28:798-807. 2008
    ..Our results suggest that this LTP mediates the activity-dependent maturation of the "winner" climbing fiber...
  76. ncbi LTP regulates burst initiation and frequency at mossy fiber-granule cell synapses of rat cerebellum: experimental observations and theoretical predictions
    Thierry Nieus
    Department of Cellular Molecular Physiological and Pharmacological Sciences, University of Pavia, Parma, Italy
    J Neurophysiol 95:686-99. 2006
    ..Independent regulation of spike burst initiation and frequency during LTP may provide mechanisms for temporal recoding and gain control of afferent signals at the input stage of cerebellar cortex...
  77. ncbi Intraepidermal nerve fiber density as a marker of early diabetic neuropathy
    T Umapathi
    National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore 308433
    Muscle Nerve 35:591-8. 2007
    ..study was to reliably identify an early stage of diabetic polyneuropathy (DPN) by measuring injury to epidermal nerve fibers. We compared intraepidermal nerve fiber density (IENFD) at the ankle and thigh of 29 diabetic subjects who had ..
  78. ncbi Morphological and functional retinal impairment in Alzheimer's disease patients
    V Parisi
    Clinica Oculistica Università di Roma Tor Vergata, Rome, Italy
    Clin Neurophysiol 112:1860-7. 2001
    ....
  79. ncbi Normal age-related decay of retinal nerve fiber layer thickness
    Rajul S Parikh
    L V Prasad Eye Institute, Hyderabad, India
    Ophthalmology 114:921-6. 2007
    ..To determine the normal age-related loss of retinal nerve fiber layer thickness (RNFLT) as measured on Stratus optical coherence tomography (OCT 3; Carl Zeiss Meditec, Dublin, CA) in an Asian Indian population...
  80. ncbi Retinal nerve fibre layer thickness measurements in normal Indian population by optical coherence tomography
    R Ramakrishnan
    Aravind Zeiss Centre of Excellence for Glaucoma, Aravind Eye Hospital, Tirunelveli, Tamil Nadu, India
    Indian J Ophthalmol 54:11-5. 2006
    ..To obtain retinal nerve fibre layer thickness measurements by optical coherence tomography (OCT) in normal Indian population...
  81. ncbi Comparison of retinal nerve fiber layer thickness in normal eyes using time-domain and spectral-domain optical coherence tomography
    Leonard K Seibold
    Rocky Mountain Lions Eye Institute, Department of Ophthalmology, University of Colorado at Denver, Aurora, Colorado 80045, USA
    Am J Ophthalmol 150:807-14. 2010
    ....
  82. ncbi P2X(2)- and P2X(3)-positive fibers in fungiform papillae originate from the chorda tympani but not the trigeminal nerve in rats and mice
    Yusuke Ishida
    Department of Neurobiology and Anatomy, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467 8601, Japan
    J Comp Neurol 514:131-44. 2009
    ..In each fungiform papilla, immunoreactivity for both receptors was mostly colocalized and was seen in nerve fibers and their bundles concentrated in the taste buds...
  83. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  84. pmc Reproducibility of RTVue retinal nerve fiber layer thickness and optic disc measurements and agreement with Stratus optical coherence tomography measurements
    Alberto O Gonzalez-Garcia
    Department of Ophthalmology, Hamilton Glaucoma Center, University of California, San Diego, La Jolla, California, USA
    Am J Ophthalmol 147:1067-74, 1074.e1. 2009
    ..To evaluate RTVue spectral-domain optical coherence tomography (OCT) (Optovue Inc, Fremont, California, USA) reproducibility and to assess agreement with Stratus time-domain OCT (Carl Zeiss Meditec, Dublin, California, USA) measurements...
  85. pmc Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae
    Seiji B Shibata
    Kresge Hearing Research Institute, Department of Otolaryngology, The University of Michigan, 1150 W Med Cntr Dr, Ann Arbor, MI 48109 5648, USA
    Exp Neurol 223:464-72. 2010
    ..Therapeutic and regenerative approaches would benefit from the presence of nerve fibers in the tissue...
  86. pmc Sodium channel expression and localization at demyelinated sites in painful human dental pulp
    Michael A Henry
    Department of Endodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Pain 10:750-8. 2009
    ..Here we examine NaCh expression within nerve fibers from normal and painful extracted human teeth with special emphasis on their localization within large ..
  87. ncbi Differences in retinal nerve fiber layer atrophy between multiple sclerosis subtypes
    Fiona Costello
    Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    J Neurol Sci 281:74-9. 2009
    ..To determine whether retinal nerve fiber layer (RNFL) atrophy in the afferent visual pathway may complement existing tools used to describe and characterize differences across MS subtypes...
  88. ncbi Factors associated with variability in retinal nerve fiber layer thickness measurements obtained by optical coherence tomography
    Ziqiang Wu
    Doheny Image Reading Center, Doheny Eye Institute, Los Angeles, California 90033, USA
    Ophthalmology 114:1505-12. 2007
    ..To identify factors associated with variability in retinal nerve fiber layer (RNFL) thickness measurements obtained by optical coherence tomography (OCT)...
  89. ncbi Reproducibility of peripapillary retinal nerve fiber thickness measurements with stratus OCT in glaucomatous eyes
    Donald L Budenz
    Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Ophthalmology 115:661-666.e4. 2008
    ..To determine the reproducibility of Stratus OCT peripapillary retinal nerve fiber layer (RNFL) measurements in glaucomatous eyes...
  90. ncbi Comparison of retinal nerve fiber layer thickness measured by Cirrus HD and Stratus optical coherence tomography
    Kyung Rim Sung
    Department of Ophthalmology, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea
    Ophthalmology 116:1264-70, 1270.e1. 2009
    ..To study the relationship between retinal nerve fiber layer (RNFL) thickness measured by time domain (Stratus) and spectral domain (Cirrus HD) optical coherence tomography (OCT)...
  91. ncbi Signal strength is an important determinant of accuracy of nerve fiber layer thickness measurement by optical coherence tomography
    Ziqiang Wu
    Doheny Eye Institute, Department of Ophthalmology, Sun Yat Sen University, Guangzhou, China
    J Glaucoma 18:213-6. 2009
    ..To investigate the effect of signal strength on the measurement of the retinal nerve fiber layer (RNFL) using optical coherence tomography (OCT)...
  92. pmc Retinal nerve fibre layer thickness measurement reproducibility improved with spectral domain optical coherence tomography
    J S Kim
    UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Suite 834, Pittsburgh, PA 15213, USA
    Br J Ophthalmol 93:1057-63. 2009
    ....
  93. ncbi Pseudospontaneous activity: stochastic independence of auditory nerve fibers with electrical stimulation
    J T Rubinstein
    Department of Otolaryngology, University of Iowa, Iowa City 52242, USA
    Hear Res 127:108-18. 1999
    ..strategy is based on the observation that high rate pulse trains may produce random spike patterns in auditory nerve fibers that are statistically similar to those produced by spontaneous activity in the normal cochlea...
  94. ncbi Enhanced temporal response properties of anteroventral cochlear nucleus neurons to broadband noise
    Dries H G Louage
    Laboratory of Auditory Neurophysiology, Medical School, K U Leuven, B 3000 Leuven, Belgium
    J Neurosci 25:1560-70. 2005
    ..The results document monaural preprocessing of the temporal information delivered to binaural nuclei in the olivary complex, which likely contributes to the high sensitivity to interaural time differences...
  95. ncbi Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis
    Erica Grazioli
    Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
    J Neurol Sci 268:12-7. 2008
    ..067). There was negative correlation between average RNFL thickness (average of both eyes) and disability as assessed by EDSS (p=0.02). The results support potential usefulness of OCT for MS patient monitoring and research applications...
  96. ncbi Optical coherence tomography in multiple sclerosis: thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy
    Malgorzata Siger
    Department of Neurology, Medical University of Lodz, Kopcinskiego 22, 90 153 Lodz, Poland
    J Neurol 255:1555-60. 2008
    ..Axonal distribution within the retinal nerve fiber layer (RNFL) measured by optical coherence tomography (OCT) correlates with axonal viability and integrity...
  97. ncbi Quantification of myelinated endings and mechanoreceptors in human digital skin
    Maria Nolano
    Salvatore Maugeri Foundation, IRCCS, Center of Telese Terme, Italy
    Ann Neurol 54:197-205. 2003
    ..In addition to epidermal nerve fibers, we quantified mechanoreceptors and their myelinated afferents...
  98. ncbi Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography
    F Costello
    Department of Clinical Neurosciences and Ophthalmology, The University of Calgary and Hotchkiss Brain Institute, Calgary, Alberta, Canada
    Mult Scler 14:893-905. 2008
    ..Optical coherence tomography may be used to track nerve fiber layer changes and to establish a time-dependent relationship between retinal nerve fiber layer thickness and visual function after optic neuritis...
  99. ncbi Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis
    J Toledo
    Department of Neurology and Neurosurgery, Clinica Universitaria de Navarra and Center for Applied Medical Research, University of Navarra, Pamplona, Spain
    Mult Scler 14:906-12. 2008
    ....
  100. ncbi Characteristics of responses of Golgi cells and mossy fibers to eye saccades and saccadic adaptation recorded from the posterior vermis of the cerebellum
    Mario Prsa
    Department of Cognitive Neurology, University of Tubingen, Hertie Institute for Clinical Brain Research, 72076 Tubingen, Germany
    J Neurosci 29:250-62. 2009
    ....
  101. ncbi Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage
    Ramanjit Sihota
    Glaucoma Research Facility, Dr Rajendra Prasad Center for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi
    Invest Ophthalmol Vis Sci 47:2006-10. 2006
    ..To evaluate the role and ability of optical coherence tomography (OCT) to detect differences in peripapillary retinal nerve fiber layer (RNFL) thickness between normal and glaucomatous eyes and also between different severities of glaucoma...

Research Grants71

  1. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    ..Findings to Date. Immunohistochemistry studies show the presence of sEH in heart muscle cells, as well as in nerve fibers and intrinsic cardiac adrenergic cells...
  2. Mechanism of Bladder Overactivity in Pelvic Ischemia
    Kazem M Azadzoi; Fiscal Year: 2013
    ..signaling via phosphoinositide 3-kinase (PI3-Kinase)/protein kinase B (Akt) pathway in smooth muscle cells and nerve fibers. Oxidative stress in cultured smooth muscle cells upregulated redox survival signaling via PI3-kinase and Akt ..
  3. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..5 million people worldwide. MS is characterized by perivascular inflammation in the CNS, demyelination of nerve fibers as well as axonal damage...
  4. Use of umbilical cord as a unique stem cell source for tissue regeneration
    Xiao Dong Chen; Fiscal Year: 2013
    ..mice generated 3 embryonic germ layers-derived tissues including bone, muscle, fat, gland, intestine and nerve fibers. Encouraged by these findings, we propose the hypothesis that human UCB contains a large number of embryonic-..
  5. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..research will give us insights into the basic biological processes triggered by demyelination in auditory nerve fibers, as well as this proposal has a broad relevance for the entire field of neurodegenerative diseases...
  6. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    This proposal explores cell signaling pathways that occur between cutaneous sensory nerve fibers and endothelial cells during response to cutaneous injury...
  7. Role of Integrins in Bladder Urothelium
    Warren G Hill; Fiscal Year: 2013
    ..g. on afferent nerve fibers. Specific aim 2 will investigate how integrins interact with and regulate mechanosensory ion channels within ..
  8. CONTROL OF GONADOTROPIN SECRETION DURING LACTATION
    Kevin L Grove; Fiscal Year: 2013
    ..focuses on two hypotheses: 1) Suppression of kisspeptin signaling at the site of GnRH cell bodies and at nerve fibers and terminals are primary components in the inhibition of basal GnRH secretion during states of negative energy ..
  9. Merkel cells specify innervating SAI sensory neuron phenotype.
    Erin G Reed-Geaghan; Fiscal Year: 2013
    ..These complexes consist of slowly adapting type I (SAI) nerve fibers and Merkel cells, and are found at the epidermal-dermal border of glabrous (hairless) skin of the hands and ..
  10. ROLE OF NITRIC OXIDE IN INTERSTITIAL CYSTITIS
    Lori A Birder; Fiscal Year: 2013
    ..FIC bladder afferents including altered morphological/electrical properties, nerve firing and distribution of nerve fibers. Moreover, we also have evidence of long-term alterations in FIC spinal cord glial cell morphology and function ..
  11. Neurogenic inflammation and psoriasiform dermatitis
    NICOLE LEANNE WARD; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psoriatic skin contains more nerve fibers and increased levels of sensory nerve-derived calcitonin gene related peptide (CGRP) and substance P (SP)...
  12. PTHrP Modulation of TRPV1 in Pain Associated with Breast Cancer Bone Metastasis
    AARON DAVID MICKLE; Fiscal Year: 2013
    ..understanding of signaling crosstalk between metastatic bone tumor microenvironment and the adjacent sensory nerve fibers is necessary for the development of highly efficacious analgesics for chronic bone cancer pain...
  13. Crosslink augmentation to resist snoring and obstructive sleep apnea syndrome
    Thomas P Hedman; Fiscal Year: 2013
    ..due to snoring can be expected to increase its passive deformability and damage muscle fibers and peripheral nerve fibers, increasing the tendency for obstruction...
  14. Mast cell actions in chronic progressive versus relapsing remitting EAE
    JULIANNE K HATFIELD; Fiscal Year: 2013
    ..This autoimmune disease is characterized by perivascular inflammation in the CNS, demyelination of nerve fibers as well as axonal damage...
  15. Cellular and Molecular Analysis of Defects at Aging Neuromuscular Synapses
    Joshua R Sanes; Fiscal Year: 2012
    ..Second, they will seek defects in the transport of materials along nerve fibers to the NMJ...
  16. A3AR agonists to prevent chemotherapy-induced painful peripheral neuropathy
    Daniela Salvemini; Fiscal Year: 2013
    ..underlie IB-MECA's action &4) IB-MECA prevents chemotherapy-evoked degeneration of intraepidermal nerve fibers &primary afferent spontaneous discharge...
  17. Novel transgenic reporter/deleter allele for Type I taste cells
    Sue Kinnamon; Fiscal Year: 2013
    ..They release ATP to activate purinergic receptors on afferent nerve fibers. Type III, or "presynaptic" cells, detect sour stimuli and release serotonin and noradrenalin...
  18. Role of axoglial CAMs in the organization of myelinated axons
    Elior Peles; Fiscal Year: 2013
    ..of the axonal membrane and the redistribution of ion channels affects the physiological properties of the nerve fibers. Uncovering the mechanisms by which myelinating glial cells control the clustering of ion channels along ..
  19. Cytoskeletal Regulation During Growth Cone Migration and Axon Guidance
    Frank B Gertler; Fiscal Year: 2012
    ..We seek a comprehensive understanding of how nerve fibers form and are guided to their targets initially during fetal development expecting that this will help us learn ..
  20. Stimulus processing in mammalian vestibular organs
    Ruth Anne Eatock; Fiscal Year: 2012
    Project Summary / Abstract Vestibular afferent nerve fibers convey head position and motion signals from the inner ear to the brain, where they drive reflexes controlling gaze, posture and balance and contribute to perceptions of ..
  21. Characteristics and mechanisms of pain in sickle cell disease
    DONALD SIMONE; Fiscal Year: 2013
    ..2) SCD is accompanied by activation of peripheral nerve fibers and inflammatory mediators of pain in the skin and spinal cord...
  22. Treat Neuropathic Pain with Dissolvable Microneedles Containing Anti-CGRP Peptide
    Xinmin Simon Xie; Fiscal Year: 2013
    ..is usually initiated by tissue injury and maintained, in part, by subsequent dysfunction of damaged peripheral nerve fibers or fibers that innervate that injured tissue...
  23. Regulation of sympathetic function by infarction
    Beth A Habecker; Fiscal Year: 2013
    ..Myocardial infarction alters the distribution and density of cardiac sympathetic nerve fibers, neurotransmitter synthesis, and neuropeptide production, resulting in heterogeneity of sympathetic ..
  24. PRESERVATION OF TIMING IN PLASTIC AUDITORY PATHWAYS
    HENRIQUE PRADO VON GERSDORFF; Fiscal Year: 2013
    ..of hair cell synapses, and of the mechanisms that generate action potential spikes in the auditory nerve fibers. This proposal uses a novel adult auditory hair cell synapse preparation to study fundamental aspects of hair ..
  25. Sleep and Brain Structure in Heart Failure
    MARY ANN WOO; Fiscal Year: 2012
    ..anisotropy) in HF depends on the presence of SDB (assessed via overnight polysomnography);2) show that nerve fibers (white matter - evaluated via structural MRI and fiber tracking techniques) interconnecting major autonomic ..
  26. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010
    ..the relationship between a decrease in tactile sensitivity and innervation by myelinated and unmyelinated nerve fibers in the finger pad...
  27. DEVELOPMENT OF EXCITATION IN HAIR CELLS
    BERND H SOKOLOWSKI; Fiscal Year: 2013
    ..ear by shaping the hair cell receptor potential and the signals transmitted to and from afferent and efferent nerve fibers, respectively...
  28. PERIPHERAL NOCICEPTORS IN PERSISTENT PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2012
    ..we will test are;(a) the bone is preferentially innervated by peptidergic C-fibers and A-delta sensory nerve fibers, while lacking innervation by A-beta and non-peptidergic C-fibers, (b) sensory and sympathetic nerve fibers ..
  29. Gene profiling of nervous system regeneration using a novel model organism
    Jose E Garcia Arraras; Fiscal Year: 2010
    ..Regeneration involves both the outgrowth of nerve fibers and formation of new neurons through proliferation and/or transdifferentiation of glial cells...
  30. The role of innervation for hormone secretion in human islets
    ALEJANDRO CAICEDO VIERKANT; Fiscal Year: 2013
    ..In the proposed mechanism, autonomic nerve fibers strongly innervate contractile pericytes that work as sphincters to change blood flow locally, thus changing ..
  31. Pathophysiology of Conduction Block in HNPP.
    Jun Li; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Conduction block (CB), a failure of propagation of electrical signal along nerve fibers, causes disabilities in a variety of neurological disorders...
  32. Role of Nitric Oxide in Feline Interstitial Cystitis.
    Lori Birder; Fiscal Year: 2009
    ..FIC bladder afferents including altered morphological/electrical properties, nerve firing and distribution of nerve fibers. Moreover, we also have evidence that FIC spinal cord glial cells are [unreadable]activated[unreadable] in ..
  33. VZV in the enteric nervous system: pathogenesis and consequences
    Michael D Gershon; Fiscal Year: 2013
    ..The proposal has 3 specific aims: (1) Can VZV travel from the skin to the ENS in sensory nerve fibers? Preliminary studies have identified neurons in dorsal route ganglia that project both to skin and gut...
  34. Mitochondrial modulation for neuroprotection in a model of multiple sclerosis
    DENNIS NEIL BOURDETTE; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Our research seeks to understand how to prevent damage to nerve fibers in the spinal cord of mice with a multiple sclerosis-like disease...
  35. Synaptic Processing in the Vestibular System
    Ruth Anne Eatock; Fiscal Year: 2013
    ..transduce head position and motion into electrochemical signals which they transmit across synapses to afferent nerve fibers. The signals drive reflexes that control gaze, posture and balance and also contribute to perception of ..
  36. DEVELOPMENTAL STUDIES ON THE MOTOR SYSTEM
    Katherine Kalil; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During development of the nervous system growing axons (nerve fibers) are guided to their targets by responses of their motile tips (growth cones) to molecular cues in the environment...
  37. Effect of selective inner hair cell loss on functional hearing
    Edward Lobarinas; Fiscal Year: 2013
    ..Importantly, in the chinchilla, carboplatin, an anticancer drug, selective damages IHC and type-I auditory nerve fibers. The purpose of this proposal is to use the chinchilla model to identify specific auditory deficits that occur ..
  38. Advanced Imaging for Glaucoma
    David Huang; Fiscal Year: 2012
    ..We will improve 3D image processing software to detect the loss of ganglion cells, nerve fibers, optic disc rim, and track glaucoma progression. 2...
  39. Next Generation Neutron Diffraction Detector for Neuroscience
    W B FELLER; Fiscal Year: 2012
    ..into the actual structure of myelin, the electrically insulating material that ensheathes central core of nerve fibers. The integrity of myelin is critically important for the proper functioning of the nervous system;demyelinating ..
  40. Mechanisms of Neuropathic Pain in Demylenated Nerves
    Fletcher A White; Fiscal Year: 2010
    ..the production of inflammation-associated pro-algesic factors which may directly sensitize sensory nerve fibers and cell bodies...
  41. Sustained Release Inner Ear Delivery of Corticosteroid
    William H Slattery; Fiscal Year: 2011
    ..RELEVANCE: Project Narrative Cochlear implants are medical devices that electrically stimulate the auditory nerve fibers of the inner ear of patients who are profoundly deaf giving them a sensation of sound...
  42. IN VITRO STUDIES OF THE COCHLEAR NUCLEUS
    Donata Oertel; Fiscal Year: 2013
    ..In human patients with auditory neuropathy the loss of temporal resolution in auditory nerve fibers leads to reduced auditory brainstem responses (ABRs), the inability to use interaural timing cues for ..
  43. METASTATIC PROSTATE CANCER-INDUCED BONE PAIN
    PATRICK WILLIAM MANTYH; Fiscal Year: 2013
    ..release NGF that induces dramatic sprouting of tropomyosin receptor kinase A (TrkA)+ sensory and sympathetic nerve fibers in the tumor-bearing bone that may play a major role in driving chronic prostate cancer-induced bone pain...
  44. CORRELATION BETWEEN STRUCTURAL AND MOTOR DEFECTS IN DIABETIC GASTROPARESIS
    Grant Hennig; Fiscal Year: 2011
    ..then using confocal and multi-photon confocal imaging, examine structural changes that occur between motor nerve fibers and ICC-IM that may indicate an unraveling of their normally close relationship...
  45. Cochlear Implants in Reinnervated Ears
    Yehoash Raphael; Fiscal Year: 2013
    ..neuron (SGN) bodies in Rosenthal's canal, since cochleae without hair cells typically lack auditory nerve fibers in the basilar membrane area (BMA)...
  46. Corneal neuropeptides and herpetic stromal keratitis
    Susmit Suvas; Fiscal Year: 2013
    ..One significant hurdle is our poor understanding of the role of neuropeptides, secreted by abundant corneal nerve fibers, in the development of HSK lesions...
  47. Longitudinal MRI biomarkers in Parkinson's disease
    Catherine L Gallagher; Fiscal Year: 2013
    ..networks (fcMRI), while diffusion tensor imaging (DTI) is used to measure the microstructural health of nerve fibers and to extrapolate "tracks" between neuronal groups...
  48. PERIPHERAL MECHANISMS OF HEARING
    Mario A Ruggero; Fiscal Year: 2013
    ..which convert vibrations into bioelectric potentials;the trains of action potentials that travel along auditory-nerve fibers, carrying acoustic information to the brain;and otoacoustic emissions, sounds produced by the ears of four-..
  49. ANATOMICAL SPECIALIZATIONS OF THE HUMAN PHARYNX
    Liancai Mu; Fiscal Year: 2012
    ..changes such as degeneration-induced nerve fiber loss or a deduction in specific neuropeptide containing nerve fibers may occur in a nerve-dependent or tissue region-specific manner...
  50. The role of Atoh1 in the development and function of Merkel cells
    Stephen M Maricich; Fiscal Year: 2013
    ..Merkel cell/neurite complexes are one form of cutaneous touch receptor, and they are composed of sensory nerve fibers and skin cells called Merkel cells...
  51. Macrophage Inactivation in Sepsis after Shock or Trauma
    Kevin J Tracey; Fiscal Year: 2013
    ..b>Nerve fibers in spleen lack the enzymatic machinery necessary for acetylcholine production, but we have recently identified ..
  52. Nerve Repair through Muscle Progenitor Cell Transplantation
    Johnny Huard; Fiscal Year: 2013
    ..Indeed, it has been observed that VEGF administration can support the growth of regenerating nerve fibers through the process of angiogenesis;moreover, the beneficial effect imparted by bone marrow transplantation on ..
  53. Murine AIDS (LP-BM5) viral infection induced peripheral neuropathy - Role of CNS
    Ling Cao; Fiscal Year: 2010
    ..experiment shows that LP-BM5 induced significant hind limb mechanical hypersensitivity and loss of peripheral nerve fibers in the foot pad skins, signs of peripheral neuropathy, along with the development of MAIDS, suggesting that LP-..
  54. Mechanisms of prion transport
    Richard A Bessen; Fiscal Year: 2013
    ..Dissemination in the nervous system occurs by prion agent movement along nerve fibers and transynaptic spread between neurons...
  55. Molecular and Functional Mechanisms of Purinergic Relaxation in Detrusor Muscle
    Sang Don Koh; Fiscal Year: 2013
    ..These cells were distributed throughout detrusor muscle, and were in close apposition with intramural nerve fibers. PDGFR-[unreadable]+ cells have been described in the gastrointestinal tract and are implicated in purinergic ..
  56. Restraint stress-induced neurogenic bladder inflammation
    Theoharis Theoharides; Fiscal Year: 2006
    ..neurotensin (NT) and substance P (SP), as it was absent in rodents treated with capsaicin to deplete sensory nerve fibers of their SP content and was also inhibited by the NT receptor antagonist SR48692...
  57. Afferent synaptic transmission in the mammalian cochlea
    Elisabeth Glowatzki; Fiscal Year: 2013
    ..cell receptor potentials, and subsequently are translated at the afferent synapse into firing rates in auditory nerve fibers. Coding of sound critically depends on the diverse firing properties of auditory nerve fibers...
  58. BRAINSTEM CIRCUITS CONTROLLING GASTROINTESTINAL FUNCTION
    RENATO ALBERTO TRAVAGLI; Fiscal Year: 2012
    ..Visceral sensory information is conveyed to the CNS via vagal afferent nerve fibers, which terminate within the brainstem in the nucleus tractus solitarius (NTS)...
  59. Mechanisms of HIV-Induced PNS Disease: The SIV Macaque Model
    Joseph Mankowski; Fiscal Year: 2009
    ..of SIV in macrophages and neuronal loss, sural nerve inflammation, and reduction in the number of epidermal nerve fibers in the feet. This constitutes the first primate model of HIV-induced peripheral neuropathy...
  60. Regulation of Schwann cell ensheathment and myelination by type III Neuregulin 1
    James Salzer; Fiscal Year: 2013
    ..studies seek to identify signals that promote myelin sheath formation, the cellular insulation that surrounds nerve fibers and is critical for their proper function and long term integrity...
  61. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2010
    ..However, the presence of nerve fibers does not necessarily specify their function and cannot determine whether, or in which situations, they are ..
  62. Neurotrophin Specificity and Function in the Taste System
    Christopher Nosrat; Fiscal Year: 2009
    ..There is a rapid turnover of taste receptor cells that necessitates continuous rewiring of existing nerve fibers and formation of new synapses. BDNF is expressed in the adult taste buds and might participate in this process...
  63. sGCa1-deficient mice: a novel murine model of elevated IOP and glaucoma
    Bruce R Ksander; Fiscal Year: 2012
    ..whether the changes in IOP and aqueous outflow coincide with degeneration of retinal ganglion cells and nerve fibers and damage to the optic nerve...
  64. CHEMORECEPTOR ACTIVITY OF THE CAROTID BODY
    Carlos Eyzaguirre; Fiscal Year: 1990
    ..carotid body nerve (CBN), because: 1) Functionally, the glomus cells are probably presynaptic to the sensory nerve fibers, and their size (about 10 mu m) allows direct recordings from them; 2) Glomus cells contain and release ACh, ..
  65. LUNG AND AIRWAY AFFERENTS AND THEIR REFLEX ROLE
    JOHN COLERIDGE; Fiscal Year: 1992
    ..studies in anesthetized dogs, cats and rabbits of the sensory characteristics of vagal and sympathetic afferent nerve fibers arising from the lower respiratory tract, and of the protective and homeostatic reflexes evoked by their ..
  66. GROWTH OF OPTIC NERVE FIBERS
    Robert Williams; Fiscal Year: 1999
    ..In addition, this mutation shows great promise as an animal model for congenital nystagmus in humans. The mutants may ultimately help us in developing and testing new methods to treat oculomotor disturbances in humans. ..
  67. Transmission of Taste Signals in Taste Buds
    Thomas E Finger; Fiscal Year: 2010
    Taste receptor cells transduce chemical signals into a neural message transmitted to the gustatory nerve fibers that innervate taste buds...
  68. DEVELOPMENT OF SOUND LOCALIZATION
    Catherine Carr; Fiscal Year: 2000
    ..Mechanisms of time coding may be particularly accessible in the bird's auditory brainstem. In birds, auditory nerve fibers enter the brain and divide to terminate in the cochlear nucleus angularis and the cochlear nucleus ..
  69. PRIMATE VISUAL SYSTEM
    ROBERT RODIECK; Fiscal Year: 1993
    ..For example, although we know that optic nerve compression has a differential effect on optic nerve fibers of different diameters, we can say little at present about the sequence of functional deficits that could be ..
  70. SPEECH PROCESSORS FOR AUDITORY PROSTHESES
    BLAKE WILSON; Fiscal Year: 2000
    ..progress has been made in understanding the information that is being conveyed to the remaining auditory nerve fibers and the cochlear nucleus during electrical stimulation with electrodes in the scala tympani and on the surface ..
  71. STUDIES OF THE PATHOPHYSIOLOGY OF HEMIFACIAL SPASM
    Aage Moller; Fiscal Year: 1990
    ..Two hypotheses exist about the cause of HFS: 1) that it is ephaptic transmission between facial nerve fibers at the site of compression that causes spasm and synkinesis, and 2) that the facial motor nucleus is involved ..