myelinated nerve fibers

Summary

Summary: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.

Top Publications

  1. ncbi Age-related alterations in white matter microstructure measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 26:1215-27. 2005
  2. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
  3. ncbi Marked loss of myelinated nerve fibers in the human brain with age
    Lisbeth Marner
    Research Laboratory for Stereology and Neuroscience, Bispebjerg Hospital, 2400 Copenhagen N, Denmark
    J Comp Neurol 462:144-52. 2003
  4. ncbi Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
    Sheng Kwei Song
    Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Neuroimage 17:1429-36. 2002
  5. ncbi The local differentiation of myelinated axons at nodes of Ranvier
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Rev Neurosci 4:968-80. 2003
  6. ncbi Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin
    M A Bhat
    Cardiovascular Research Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 30:369-83. 2001
  7. pmc Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
    Arch Neurol 65:1202-8. 2008
  8. ncbi Diffusion anisotropy measurement of brain white matter is affected by voxel size: underestimation occurs in areas with crossing fibers
    H Oouchi
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan
    AJNR Am J Neuroradiol 28:1102-6. 2007
  9. ncbi Toward accurate diagnosis of white matter pathology using diffusion tensor imaging
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, Missouri, USA
    Magn Reson Med 57:688-95. 2007
  10. ncbi Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging
    Laura A Harsan
    UMR 7004 CNRS ULP, Institut de Physique Biologique, Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    J Neurosci Res 83:392-402. 2006

Research Grants

Detail Information

Publications236 found, 100 shown here

  1. ncbi Age-related alterations in white matter microstructure measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 26:1215-27. 2005
    ..These findings suggest that WM alterations are variable throughout the brain and that particular fiber populations within prefrontal region and PLIC are most vulnerable to age-related degeneration...
  2. pmc Juxtaparanodal clustering of Shaker-like K+ channels in myelinated axons depends on Caspr2 and TAG-1
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 162:1149-60. 2003
    ....
  3. ncbi Marked loss of myelinated nerve fibers in the human brain with age
    Lisbeth Marner
    Research Laboratory for Stereology and Neuroscience, Bispebjerg Hospital, 2400 Copenhagen N, Denmark
    J Comp Neurol 462:144-52. 2003
    ..The marked loss of myelinated nerve fibers with age could explain some of the cognitive decline seen in the elderly.
  4. ncbi Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
    Sheng Kwei Song
    Department of Chemistry, Washington University, St Louis, Missouri 63110, USA
    Neuroimage 17:1429-36. 2002
    ..Although further validation is still needed, our finding suggests that changes in lambda(perpendicular) and lambda(parallel) may potentially be used to differentiate myelin loss versus axonal injury...
  5. ncbi The local differentiation of myelinated axons at nodes of Ranvier
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Nat Rev Neurosci 4:968-80. 2003
    ..This local differentiation of myelinated axons is tightly regulated by oligodendrocytes and myelinating Schwann cells, and is achieved through complex mechanisms that are used by another specialized cell-cell contact - the synapse...
  6. ncbi Axon-glia interactions and the domain organization of myelinated axons requires neurexin IV/Caspr/Paranodin
    M A Bhat
    Cardiovascular Research Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuron 30:369-83. 2001
    ..These results show a critical role for NCP1 in the delineation of specific axonal domains and the axon-glia interactions required for normal saltatory conduction...
  7. pmc Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease
    Adam M Brickman
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, 630 W 168th St, Campus Box 16, New York, NY 10032, USA
    Arch Neurol 65:1202-8. 2008
    ..To determine if baseline measurements of cerebral atrophy and severity of white matter hyperintensity (WMH) predict the rate of future cognitive decline in patients with Alzheimer disease (AD)...
  8. ncbi Diffusion anisotropy measurement of brain white matter is affected by voxel size: underestimation occurs in areas with crossing fibers
    H Oouchi
    Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto City, Kyoto, Japan
    AJNR Am J Neuroradiol 28:1102-6. 2007
    ..The purpose of this article was to investigate the effect of voxel size/shape on measured FA by using isotropic and nonisotropic voxels...
  9. ncbi Toward accurate diagnosis of white matter pathology using diffusion tensor imaging
    Matthew D Budde
    Department of Radiology, Washington University, St Louis, Missouri, USA
    Magn Reson Med 57:688-95. 2007
    ..The results suggest that directional diffusivities may reveal abnormalities that are not obvious with SMI-31 and LFB staining, depending on the type of injury...
  10. ncbi Brain dysmyelination and recovery assessment by noninvasive in vivo diffusion tensor magnetic resonance imaging
    Laura A Harsan
    UMR 7004 CNRS ULP, Institut de Physique Biologique, Faculte de Medecine, Universite Louis Pasteur, Strasbourg, France
    J Neurosci Res 83:392-402. 2006
    ..This regeneration was confirmed by the detection of enlarged oligodendrocyte population, newly formed myelin sheaths around additional axons, and a gradual increase in axonal caliber...
  11. ncbi The age-related decrease in CNS remyelination efficiency is attributable to an impairment of both oligodendrocyte progenitor recruitment and differentiation
    Fraser J Sim
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 22:2451-9. 2002
    ....
  12. ncbi Diffusion tensor imaging in presymptomatic and early Huntington's disease: Selective white matter pathology and its relationship to clinical measures
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 21:1317-25. 2006
    ....
  13. ncbi Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy
    M E Gurol
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Neurology 66:23-9. 2006
    ..Recent studies suggest a role for circulating beta-amyloid peptide in microvascular dysfunction and white matter disease...
  14. ncbi Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers
    Keiichiro Susuki
    Department of Neurology, Dokkyo Medical University School of Medicine, Kitakobayashi 880, Mibu, Shimotsuga, Tochigi 321 0293, Japan
    Glia 55:746-57. 2007
    ..axo-glial junctions are important for ion channel clustering and rapid action potential propagation in myelinated nerve fibers. Paranode formation depends on the cell adhesion molecules neurofascin (NF) 155 in glia, and a Caspr and ..
  15. ncbi Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve
    M E Boyle
    Neurobiology Program, The Burnham Institute, La Jolla, CA 92037, USA
    Neuron 30:385-97. 2001
    ..1 and Kv1.2 potassium channels. Thus, contactin is a crucial part in the machinery that controls junctional attachment at the paranode and ultimately the physiology of myelinated nerve...
  16. ncbi Remyelination capacity of the MS brain decreases with disease chronicity
    T Goldschmidt
    Department of Neuropathology, University Medical Center, Gottingen, Germany
    Neurology 72:1914-21. 2009
    ..However, no studies have been published that have quantified and compared the extent of remyelination in early and chronic MS lesions...
  17. ncbi Axonal loss and neuroinflammation caused by peroxisome-deficient oligodendrocytes
    Celia M Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nat Genet 39:969-76. 2007
    ..We conclude that peroxisomes provide oligodendrocytes with an essential neuroprotective function against axon degeneration and neuroinflammation, which is relevant for human demyelinating diseases...
  18. ncbi Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability
    T Coetzee
    UNC Neuroscience Center, University of North Carolina at Chapel Hill 27599, USA
    Cell 86:209-19. 1996
    ..These results indicate that GalC and sulfatide play important roles in myelin function and stability...
  19. ncbi Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle
    Cameron C McIntyre
    Department of Biomedical Engineering, Case Western Reserve University, C B Bolton Building, Cleveland, Ohio 44106 4912, USA
    J Neurophysiol 87:995-1006. 2002
    ..models were able to reproduce a wide range of experimental data on the excitation properties of mammalian myelinated nerve fibers. The combination of an accurate representation of the ion channels at the node (based on experimental ..
  20. ncbi Diffusion tensor MR imaging and fiber tractography: technical considerations
    P Mukherjee
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:843-52. 2008
    ..An overview of current methods for quantitative analysis of DTI data and fiber tractography in clinical research is also provided...
  21. ncbi Evidence for cortical "disconnection" as a mechanism of age-related cognitive decline
    M O'SULLIVAN
    Division of Clinical Neuroscience, St George s Hospital Medical School, London, United Kingdom
    Neurology 57:632-8. 2001
    ..It has been suggested that cortical "disconnection" due to the loss of white matter fibers may play an important role. But, to date, there has been no direct demonstration of structural disconnection in humans in vivo...
  22. pmc Quantitative fiber tracking of lateral and interhemispheric white matter systems in normal aging: relations to timed performance
    Edith V Sullivan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine MC5723, 401 Quarry Road, Stanford, CA 94305 5723, United States
    Neurobiol Aging 31:464-81. 2010
    ....
  23. ncbi Age-related changes in prefrontal white matter measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, MGH Department of Radiology, Building 149, 13th Street, Mail Code 149 2301, Charlestown, MA 02129 2060, USA
    Ann N Y Acad Sci 1064:37-49. 2005
    ..This evidence of widespread and regionally accelerated alterations in prefrontal WM with aging illustrates FA's potential as a microstructural index of volumetric measures...
  24. ncbi Nodal, paranodal and juxtaparanodal axonal proteins during demyelination and remyelination in multiple sclerosis
    I Coman
    INSERM U711, Paris, France
    Brain 129:3186-95. 2006
    ..We suggest that a defect of Na(v) channel aggregation might be involved in the remyelination failure in demyelinated lesions with spared axons and oligodendroglial cells...
  25. doi Metabolic syndrome is associated with silent ischemic brain lesions
    Hirokazu Bokura
    Stroke 39:1607-9. 2008
    ..We examined the association of MetS with the prevalence of silent brain infarction, periventricular hyperintensity, and subcortical white matter lesions in healthy adults...
  26. ncbi Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis
    Stefano Pluchino
    Neuroimmunology Unit DIBIT, San Raffaele Hospital, Via Olgettina 58, 20132 Milano, Italy
    Nature 422:688-94. 2003
    ..Thus, adult neural precursor cells promote multifocal remyelination and functional recovery after intravenous or intrathecal injection in a chronic model of multiple sclerosis...
  27. pmc Distinct claudins and associated PDZ proteins form different autotypic tight junctions in myelinating Schwann cells
    Sebastian Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Cell Biol 159:361-72. 2002
    ..The presence of these different tight junction proteins in regions of noncompact myelin may be required to maintain the intricate cytoarchitecture of myelinating Schwann cells...
  28. ncbi Fiber tracking: principles and strategies - a technical review
    Susumu Mori
    Johns Hopkins University School of Medicine, Department of Radiology and Radiological Science, Baltimore, MD 21205, USA
    NMR Biomed 15:468-80. 2002
    ..Special attention is paid to situations where complications may arise, and possible solutions are reviewed. Validation issues and potential future directions and improvements are also discussed...
  29. ncbi Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
    S Poliak
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Neurosci 21:7568-75. 2001
    ....
  30. ncbi Multiple-fiber reconstruction algorithms for diffusion MRI
    Daniel C Alexander
    Department of Computer Science, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Ann N Y Acad Sci 1064:113-33. 2005
    ..Further simulations suggest that a moderate increase in data quality allows q-ball, which is much faster to run, to recover directions with consistency comparable to that of PASMRI on the test data...
  31. ncbi Connexin mutations in X-linked Charcot-Marie-Tooth disease
    J Bergoffen
    Department of Neurology, University of Pennsylvania Medical School, Children s Hospital of Philadelphia 19104
    Science 262:2039-42. 1993
    ..These findings, a demonstration of inherited defects in a gap junction protein, suggest that connexin32 plays an important role in peripheral nerve...
  32. ncbi Impaired trigeminal nociceptive processing in patients with trigeminal neuralgia
    M Obermann
    Department of Neurology, University Duisburg Essen, Essen, Germany
    Neurology 69:835-41. 2007
    ..Between the attacks the patient is usually asymptomatic, but a constant dull background pain may persist in some cases. The mechanisms associated with the development of this chronic pain are not well understood...
  33. ncbi Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
    W Magerl
    Institute of Physiology and Pathophysiology, Johannes Gutenberg University, Mainz, Germany
    Brain 124:1754-64. 2001
    ..These capsaicin-insensitive A-fibre nociceptors may also mediate hyperalgesia in neuropathic pain...
  34. pmc Neurofilament-dependent radial growth of motor axons and axonal organization of neurofilaments does not require the neurofilament heavy subunit (NF-H) or its phosphorylation
    M V Rao
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, California 92093, USA
    J Cell Biol 143:171-81. 1998
    ....
  35. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ....
  36. pmc Age-related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging
    Ilana J Bennett
    Department of Psychology, Georgetown University, Washington, District of Columbia 20057, USA
    Hum Brain Mapp 31:378-90. 2010
    ..Together, these findings complement other recent studies in providing information about patterns of diffusivity that are characteristic of healthy aging...
  37. ncbi Regional DTI differences in multiple sclerosis patients
    S D Roosendaal
    Department of Radiology, MS Center Amsterdam, VU University Medical Center, Amsterdam, The Netherlands
    Neuroimage 44:1397-403. 2009
    ..TBSS can be useful in future studies with other MS patient samples to provide an unbiased localization of damage and generate location-specific hypotheses...
  38. ncbi Multicontrast MRI of remyelination in the central nervous system
    Doron Merkler
    Department of Neuropathology, Georg August University Gottingen, Germany
    NMR Biomed 18:395-403. 2005
    ..With a correct assignment of 95% of all animals examined, the procedure will allow for the survey of new therapeutic approaches aiming at improved remyelination...
  39. ncbi Arrested oligodendrocyte lineage progression during human cerebral white matter development: dissociation between the timing of progenitor differentiation and myelinogenesis
    Stephen A Back
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neuropathol Exp Neurol 61:197-211. 2002
    ....
  40. ncbi Widespread affections of large fiber tracts in postoperative temporal lobe epilepsy
    Jan Christoph Schoene-Bake
    University of Bonn Medical Center, Department of Epileptology, Bonn, Germany
    Neuroimage 46:569-76. 2009
    ..Alterations in the ipsilateral mesial temporal lobe can be attributed to be a result of surgery, whereas extratemporal FA decrease is more likely the result of the underlying seizure disorder...
  41. pmc Association of TAG-1 with Caspr2 is essential for the molecular organization of juxtaparanodal regions of myelinated fibers
    Maria Traka
    Department of Basic Science, University of Crete Medical School, Heraklion 71110, Crete, Greece
    J Cell Biol 162:1161-72. 2003
    ..This complex is analogous to that described previously at paranodes, suggesting that similar molecules are crucial for different types of axo-glial interactions...
  42. ncbi Connectivity-Based Parcellation of Broca's Area
    A Anwander
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Cereb Cortex 17:816-25. 2007
    ..For the first time, there is a possibility to investigate the anatomical subdivision of Broca's area noninvasively in the individual living human subject...
  43. ncbi Premyelinating oligodendrocytes in chronic lesions of multiple sclerosis
    Ansi Chang
    Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 346:165-73. 2002
    ..We investigated the frequency distribution and configuration of oligodendrocytes in chronic lesions of multiple sclerosis to determine whether these factors limit remyelination...
  44. ncbi Neurofascins are required to establish axonal domains for saltatory conduction
    Diane L Sherman
    Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom
    Neuron 48:737-42. 2005
    ....
  45. pmc Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging
    Christopher M Holland
    Center for Neurological Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Stroke 39:1127-33. 2008
    ..We sought to determine whether the spatial distribution of WMHs discriminates between different disease groups and healthy aging individuals and whether these distributions are related to local cerebral perfusion patterns...
  46. ncbi The role of oligodendrocyte pathology in schizophrenia
    Natalya A Uranova
    Laboratory of Clinical Neuropathology, Mental Health Research Center, Moscow, Russia
    Int J Neuropsychopharmacol 10:537-45. 2007
    ....
  47. pmc How the optic nerve allocates space, energy capacity, and information
    János A Perge
    Department of Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 29:7917-28. 2009
    ....
  48. ncbi Hepatocyte growth factor (HGF) promotes oligodendrocyte progenitor cell proliferation and inhibits its differentiation during postnatal development in the rat
    Wakana Ohya
    Division of Molecular Regenerative Medicine, Department of Biochemistry and Molecular Biology, Osaka University Graduate School of Medicine, B 7, Osaka 565 0871, Japan
    Brain Res 1147:51-65. 2007
    ..Electron microscopy revealed that the numbers of myelinated nerve fibers decreased after HGF treatment...
  49. pmc Age changes in myelinated nerve fibers of the cingulate bundle and corpus callosum in the rhesus monkey
    Michael P Bowley
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Comp Neurol 518:3046-64. 2010
    Aging is accompanied by deficits in cognitive function, which may be related to the vulnerability of myelinated nerve fibers to the normal process of aging...
  50. pmc Spiking and nonspiking classes of oligodendrocyte precursor glia in CNS white matter
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 11:450-6. 2008
    ..These data challenge the idea that only neurons generate action potentials in the CNS and imply that the development of therapies for demyelinating disorders will require defining which OPC type can carry out remyelination...
  51. ncbi Remyelination is extensive in a subset of multiple sclerosis patients
    Peter Patrikios
    Center for Brain Research, Medical University of Vienna, Vienna, Austria
    Brain 129:3165-72. 2006
    ..These results suggest that the variable and patient-dependent extent of remyelination must be considered in the design of future clinical trials aimed at promoting CNS repair...
  52. ncbi Histopathological and behavioral characterization of a novel cervical spinal cord displacement contusion injury in the rat
    D D Pearse
    The Miami Project to Cure Paralysis, Neurological Surgery, University of Miami School of Medicine, Miami, Florida 33101, USA
    J Neurotrauma 22:680-702. 2005
    ..Characterization of this novel model is presented to enable and encourage its future use in the design and experimental testing of therapeutic strategies that may be used for human SCI...
  53. pmc Change of conduction velocity by regional myelination yields constant latency irrespective of distance between thalamus and cortex
    Mahmoud Salami
    Division of Neurophysiology D14, Osaka University Graduate School of Medicine, Core Research for Evolutional Science and Technology Japan Science and Technology Corporation, 2 2 Yamadaoka, Suita 565 0871, Japan
    Proc Natl Acad Sci U S A 100:6174-9. 2003
    ..Our finding may well provide a general strategy of connecting multiple sites irrespective of distances in the brain...
  54. ncbi Polarized domains of myelinated axons
    James L Salzer
    Department of Cell Biology and Neurology, Program in Molecular Neurobiology, Skirball Institute of Biomedical Research, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Neuron 40:297-318. 2003
    ....
  55. pmc ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter
    David Hunt
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK
    BMC Neurosci 5:9. 2004
    ....
  56. ncbi Visualizing white matter pathways in the living human brain: diffusion tensor imaging and beyond
    Christopher P Hess
    Department of Radiology, University of California at San Francisco, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Neuroimaging Clin N Am 17:407-26, vii. 2007
    ..Diffusion MR imaging is a powerful adjunct to techniques for studying brain function...
  57. ncbi Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia
    Rajan Radhakrishnan
    Graduate Program in Physical Therapy and Rehabilitation Science, Pain Research Program, Neuroscience Graduate Program, University of Iowa, Iowa City, Iowa 52242, USA
    J Pain 6:673-80. 2005
    ..We conclude that large diameter primary afferent fibers from deep tissue are required and that activation of cutaneous afferents is not sufficient for TENS-induced antihyperalgesia...
  58. pmc White matter pathology isolates the hippocampal formation in Alzheimer's disease
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, United States
    Neurobiol Aging 31:244-56. 2010
    ..These results demonstrate that deterioration of neocortical connections to the hippocampal formation results in part from the degeneration of critical MTL and associated fiber pathways...
  59. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
    ..Thus, NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ErbB-independent mechanism of myelination control...
  60. ncbi Multiple functions of the paranodal junction of myelinated nerve fibers
    Jack Rosenbluth
    Department of Physiology and Neuroscience and Rusk Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    J Neurosci Res 87:3250-8. 2009
    ..It is therefore the likely means for maintaining constancy of nodal surface area and electrical parameters essential for consistency in conduction...
  61. pmc Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system
    Trent A Watkins
    Stanford University School of Medicine, Department of Neurobiology, Fairchild Science Building D235, Stanford, CA 94305 5125, USA
    Neuron 60:555-69. 2008
    ..These insights illustrate the value of this defined system for investigating multiple aspects of CNS myelination...
  62. ncbi Internodal specializations of myelinated axons in the central nervous system
    E J Arroyo
    Department of Neurology, The University of Pennsylvania, Philadelphia 19104, USA
    Cell Tissue Res 305:53-66. 2001
    ..1/Kv1.2/Kvbeta2/Caspr2 internodal strands indicates that the oligodendrocyte myelin sheaths lack a trans molecular interaction with axons, an interaction that is present in Schwann cell myelin sheaths...
  63. pmc DTI abnormalities in anterior corpus callosum of rats with spike-wave epilepsy
    H Chahboune
    Magnetic Resonance Research Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Neuroimage 47:459-66. 2009
    ..We employed diffusion tensor imaging (DTI) in rat absence models to detect abnormalities in white matter pathways connecting regions of seizure activity...
  64. pmc The axonal membrane protein Caspr, a homologue of neurexin IV, is a component of the septate-like paranodal junctions that assemble during myelination
    S Einheber
    Department of Cell Biology, New York University Medical School, New York 10016, USA
    J Cell Biol 139:1495-506. 1997
    ..They strongly implicate Caspr as a major transmembrane component of the paranodal junctions, whose molecular composition has previously been unknown, and suggest its role in the reciprocal signaling between axons and glia...
  65. pmc Role of transverse bands in maintaining paranodal structure and axolemmal domain organization in myelinated nerve fibers: effect on longevity in dysmyelinated mutant mice
    Amanda J Mierzwa
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Comp Neurol 518:2841-53. 2010
    ....
  66. ncbi Expression of capsaicin receptor (VR1) by myelinated primary afferent neurons in rats
    Qing Ping Ma
    Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Harlow, Essex CM20 2QR, UK
    Neurosci Lett 319:87-90. 2002
    ..These results suggest that capsaicin receptors are likely to be expressed by Adelta-fiber neurons as well as C-fiber neurons...
  67. ncbi The neuronal adhesion protein TAG-1 is expressed by Schwann cells and oligodendrocytes and is localized to the juxtaparanodal region of myelinated fibers
    Maria Traka
    Department of Basic Science, University of Crete Medical School, Heraklion 71110, Crete, Greece
    J Neurosci 22:3016-24. 2002
    ..The abnormal localization of TAG-1 in the CGT mutants might contribute to the disrupted axoglial interactions observed in these animals...
  68. pmc Spinal dorsal horn neuronal responses to myelinated versus unmyelinated heat nociceptors and their modulation by activation of the periaqueductal grey in the rat
    Simon McMullan
    Hypertension and Stroke Research Laboratory, Royal North Shore Hospital, St Leonards, Sydney, NSW 2065, Australia
    J Physiol 576:547-56. 2006
    ..The data are discussed in relation to the role of the DL/L-PAG in mediating active coping strategies...
  69. ncbi Determinants of excitability at transition zones in Kv1.1-deficient myelinated nerves
    L Zhou
    Department of Physiology, University of Wisconsin School of Medicine, Madison, Wisconsin 53706, USA
    J Neurosci 19:5768-81. 1999
    ..We suggest that variations in fiber geometry create sites of inherent instability that is normally stabilized by a synergism between myelin-concealed Kv1.1 and a slow, TEA-sensitive K channel...
  70. ncbi Morphometric analysis of pulpal myelinated nerve fibers in human teeth with chronic periodontitis and root sensitivity
    Inga Vaitkeviciene
    Department of Dental and Oral Pathology, Kaunas University of Medicine, Eiveniu 2, 50009 Kaunas, Lithuania
    Medicina (Kaunas) 42:914-22. 2006
    ..It is possible that root sensitivity may be related to changes of intradental myelinated nerve fibers, which are responsible for dentine sensitivity.
  71. ncbi The results of electrophysiological tests in unilateral extensive peripapillary myelinated nerve fibers: report of three cases
    Hatice Arda
    Department of Ophthalmology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey
    Doc Ophthalmol 119:225-8. 2009
    ..clinical and electrophysiological findings of three patients with unilateral extensive peripapillary myelinated nerve fibers. Three patients with unilateral extensive peripapillary myelinated nerve fibers were examined...
  72. ncbi Macrophage depletion impairs oligodendrocyte remyelination following lysolecithin-induced demyelination
    M R Kotter
    Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge, UK
    Glia 35:204-12. 2001
    ....
  73. ncbi Cellular junctions of myelinated nerves (Review)
    Ivo Spiegel
    Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel
    Mol Membr Biol 19:95-101. 2002
    ..This short review discusses the structure, molecular composition and function of the junctions present in myelinating cells, concentrating on the axo-glial junction...
  74. ncbi Brain white-matter volume loss and glucose hypometabolism precede the clinical symptoms of Huntington's disease
    Andrea Ciarmiello
    Nuclear Medicine Unit, IRCCS G Pascale, Naples, Italy
    J Nucl Med 47:215-22. 2006
    ....
  75. ncbi Delayed maturation of regenerating myelinated axons in mice lacking neurofilaments
    Q Zhu
    Centre for Research in Neuroscience, McGill University, Montreal General Hospital Research Institute, Quebec, Canada
    Exp Neurol 148:299-316. 1997
    ..These results provide the first direct evidence for a role of neurofilaments in the maturation of regenerating myelinated axons...
  76. ncbi Structural MRI covariance patterns associated with normal aging and neuropsychological functioning
    Adam M Brickman
    Cognitive Neuroscience Division, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, New York, NY 20032, USA
    Neurobiol Aging 28:284-95. 2007
    ..The results suggest that identifiable networks of grey and white matter regions systematically decline with age and that pattern expression is linked to age-related cognitive decline...
  77. ncbi Extent of microstructural white matter injury in postconcussive syndrome correlates with impaired cognitive reaction time: a 3T diffusion tensor imaging study of mild traumatic brain injury
    S N Niogi
    Department of Psychiatry, Sackler Institute, Weill Medical College of Cornell University, New York, NY 10065, USA
    AJNR Am J Neuroradiol 29:967-73. 2008
    ..We hypothesized that for mild TBI, DTI measures of DAI would correlate with impairments in reaction time, whereas the number of focal lesions on conventional 3T MR imaging would not...
  78. ncbi Remyelination can be extensive in multiple sclerosis despite a long disease course
    R Patani
    Department of Cellular and Molecular Neuroscience, UK MS Tissue Bank, Division of Neuroscience, Imperial College London, Charing Cross Hospital Campus, London, UK
    Neuropathol Appl Neurobiol 33:277-87. 2007
    ..Results from this study of two patients with long standing disease suggest that remyelination in MS may be more extensive than previously thought...
  79. ncbi LINGO-1 negatively regulates myelination by oligodendrocytes
    Sha Mi
    Department of Discovery Biology, Biogen Idec, Inc, 14 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nat Neurosci 8:745-51. 2005
    ..The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGO-1 knockout indicate that LINGO-1 signaling may be critical for CNS myelination...
  80. ncbi Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    Rie Suzuki
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 5:1319-26. 2002
    ....
  81. ncbi Oligodendrocytes expressing exclusively the DM20 isoform of the proteolipid protein gene: myelination and development
    Olaf Spörkel
    Laboratory of Molecular Neuroscience, University of Cologne, Cologne, Germany
    Glia 37:19-30. 2002
    ....
  82. ncbi Sequence of oligodendrocyte development in the human fetal telencephalon
    Igor Jakovcevski
    Department of Neuroscience, University of Connecticut Health Center, Farmington, CT 06030 3401, USA
    Glia 49:480-91. 2005
    ..Overall, in addition to considerable similarities with rodents, important differences in temporal and spatial distribution and regulatory signals for OL differentiation exist in the human brain...
  83. ncbi Nociceptive responses to high and low rates of noxious cutaneous heating are mediated by different nociceptors in the rat: electrophysiological evidence
    D C Yeomans
    Department of Pharmacology, University of Illinois at Chicago, 60612, USA
    Pain 68:141-50. 1996
    ....
  84. ncbi Expression and localization of insulin receptor in rat dorsal root ganglion and spinal cord
    Kazuhiro Sugimoto
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    J Peripher Nerv Syst 7:44-53. 2002
    ..This is consistent with the colocalization of IR with tight junctions of the paranodal barrier and endoneurial endothelial cells in peripheral nerve...
  85. ncbi Phenotype and function of somatic primary afferent nociceptive neurones with C-, Adelta- or Aalpha/beta-fibres
    S N Lawson
    Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    Exp Physiol 87:239-44. 2002
    ..These features of nociceptive neurones include consistently larger action potential overshoots and longer after-hyperpolarisation durations in nociceptive than in LTM neurones...
  86. ncbi [Unilateral myelinated nerve fibers associated with myopia or amblyopia]
    M Munteanu
    Clinica de Oftalmologie, Timisoara
    Oftalmologia 53:61-6. 2002
    There are described a number of 9 clinical cases with unilateral myelinated nerve fibers, associated with myopia or amblyopia...
  87. ncbi The relation between white-matter lesions and cognition
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Curr Opin Neurol 20:390-7. 2007
    ..To summarize recent findings and developments in the field of the relation between white-matter lesions and cognition...
  88. ncbi A prospective study of cerebral white matter abnormalities in older people with gait dysfunction
    G T Whitman
    Department of Neurology, University of California at Los Angeles School of Medicine, USA
    Neurology 57:990-4. 2001
    ..CONCLUSIONS: Some older people develop gait and balance dysfunction that is associated with gradual onset of cerebral white matter disease...
  89. ncbi Diffusion tensor imaging: Application to the study of the developing brain
    Carissa J Cascio
    Neurodevelopmental Disorders Research Center, Campus Box 3366, University of North Carolina, Chapel Hill, NC 27599 3366, USA
    J Am Acad Child Adolesc Psychiatry 46:213-23. 2007
    ..To provide an overview of diffusion tensor imaging (DTI) and its application to the study of white matter in the developing brain in both healthy and clinical samples...
  90. ncbi Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury
    Soheila Karimi-Abdolrezaee
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:3377-89. 2006
    ..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI...
  91. ncbi Grafts of brain-derived neurotrophic factor and neurotrophin 3-transduced primate Schwann cells lead to functional recovery of the demyelinated mouse spinal cord
    Christelle Girard
    Institut National de la Santé et de la Recherche Médicale Unité 546, Centre Hospitalier Universitaire Pitie Salpetriere, 75634 Paris Cedex 13, France
    J Neurosci 25:7924-33. 2005
    ..These results underline the potential therapeutic benefit of combining neuroprotection and activation of myelin-forming cells to restore altered functions in demyelinating diseases of the CNS...
  92. ncbi Neuroplasticity in human callosal dysgenesis: a diffusion tensor imaging study
    Fernanda Tovar-Moll
    Department of Anatomy, Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Brazil
    Cereb Cortex 17:531-41. 2007
    ....
  93. ncbi Diffusion changes in patients with systemic lupus erythematosus
    Lijuan Zhang
    Department of Radiology, Weill Medical College, Cornell University, New York, NY 10021, USA
    Magn Reson Imaging 25:399-405. 2007
    ..Routine magnetic resonance imaging (MRI) findings are often nonspecific or negative. In this study, we explored the use of diffusion tensor imaging in assisting with the diagnosis of SLE...
  94. ncbi Regeneration into protected and chronically denervated peripheral nerve stumps
    Rajiv Midha
    Division of Neurosurgery, Department of Clinical Neurosciences, and Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada
    Neurosurgery 57:1289-99; discussion 1289-99. 2005
    ..This may be a result of the deterioration or loss of endoneurial pathways in the distal nerve stump before motor axons can regenerate into the stump...
  95. ncbi Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
    Mark R Kotter
    Cambridge Centre for Brain Repair, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 26:328-32. 2006
    ..These data identify myelin as an inhibitor of remyelination as well as its well documented inhibition of axon regeneration...
  96. ncbi Glial regulation of the axonal membrane at nodes of Ranvier
    Dorothy P Schafer
    Department of Neuroscience, University of Connecticut Health Center, 263 Farmington Avenue, Farmington CT 06032, USA
    Curr Opin Neurobiol 16:508-14. 2006
    Action potential conduction in myelinated nerve fibers depends on a polarized axonal membrane...
  97. pmc Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD
    M Yoshita
    Department of Neurology and Center for Neuroscience, University of California at Davis, 1544 Newton Ct, Davis, CA 95616, USA
    Neurology 67:2192-8. 2006
    ..To analyze the extent and spatial distribution of white matter hyperintensities (WMH) in brain regions from cognitively normal older individuals (CN) and patients with mild cognitive impairment (MCI) and Alzheimer disease (AD)...
  98. ncbi Diffusion tensor and magnetization transfer MRI measurements of periventricular white matter hyperintensities in old age
    Mark E Bastin
    Medical and Radiological Sciences Medical Physics, School of Clinical Sciences and Community Health, University of Edinburgh, United Kingdom
    Neurobiol Aging 30:125-36. 2009
    ..However, within PVWMH, MTR correlates strongly with water diffusion parameters probably because of the pathologically associated neuronal loss, demyelination and gliosis...
  99. pmc Brain fiber tract plasticity in experimental spinal cord injury: diffusion tensor imaging
    Jaivijay Ramu
    Department of Diagnostic and Interventional Imaging, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, Texas 77030, USA
    Exp Neurol 212:100-7. 2008
    ..GAP-43 expression also indicates plasticity in the internal capsule. These studies suggest that the previously observed multiple regions of activation in spinal cord injury are, at least in part, due to the formation of new fibers...
  100. ncbi Does diabetes target ganglion neurones? Progressive sensory neurone involvement in long-term experimental diabetes
    D W Zochodne
    Department of Clinical Neurosciences, University of Calgary, Alberta, Canada
    Brain 124:2319-34. 2001
    ..This pattern of change differs from that following axotomy, implies a degenerative rather than an injury phenotype and has important implications for how such neurones might be rescued...
  101. ncbi Oligodendroglial impact on axonal function and survival - a hypothesis
    Celia Michèle Kassmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen, Germany
    Curr Opin Neurol 21:235-41. 2008
    ..This short review focuses on the possible primary role of oligodendrocytes in axon loss and inflammatory demyelination...

Research Grants63

  1. A New Device for Rapid Measurement of Touch Sensation in neuropathy
    Donald A Simone; Fiscal Year: 2010
    ..bump detection thresholds will correlate with a decrease in the number of Meissner corpuscles and their myelinated nerve fibers early in disease...
  2. Neural Mechanisms of Itch
    ROBERT H LA MOTTE; Fiscal Year: 2013
    ..thermal or chemical stimuli in enhancing or suppressing itch and the effects of blocking conduction in myelinated nerve fibers will be examined to reveal underlying neural mechanisms controlling itch...
  3. Pathology of dysmyelination and demyelination
    Jack Rosenbluth; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The paranodal junction (PNJ) is a crucial component of myelinated nerve fibers responsible for attaching the myelin sheath to the axon, restricting short-circuiting of nodal action currents under the ..
  4. Molecular Organization and Function of Paranodal Axo-Glial Junctions
    Manzoor A Bhat; Fiscal Year: 2010
    ..the molecular mechanisms that govern the establishment and organization of distinct axonal domains in the myelinated nerve fibers. This unique structure allows the saltatory propagation of the nerve impulses in the myelinated axons...
  5. NR/CAM AND FORMATION OF NODE OF RANVIER
    Martin Grumet; Fiscal Year: 2002
    DESCRIPTION (Verbatim from the Applicant's Abstract): Myelinated nerve fibers are critical for efficient propagation of impulses via saltatory conduction...
  6. IN VIVO EXPRESSION OF SCHWANN CELL NA CHANNEL
    GING WANG; Fiscal Year: 1990
    ..will be performed to confirm the in vivo expression of Na channels in Schwann cells associated with large myelinated nerve fibers. Also, antisera against oligopeptide deduced from Schwann cell Na channel cDNA will be used to localize ..
  7. COMPARATIVE CYTOLOGY OF NERVE AND MUSCLE TISSUES
    Jack Rosenbluth; Fiscal Year: 1992
    The proposed project is a continuation of studies of normal and abnormal myelinated nerve fibers in the peripheral and central nervous systems...
  8. Diffusion Tensor Imaging of Wallerian Degeneration in MS
    Khader Hasan; Fiscal Year: 2009
    ..This tool will also help in the fusion of multi-modal MRI data for a robust segmentation of the subregions of CC and 1C. The DTI measures, after accounting for the age and gender dependence will be correlated with the clinical measures. ..
  9. Diffusion Tensor Imaging of White Matter Change in AD
    David Salat; Fiscal Year: 2008
    ..Thus, the proposed integrated training and research program could lead to novel insights about the unique contribution of WM degeneration to the clinical sequel of AD. ..
  10. Geriatric Depression Outcomes: Prognostic Factors
    Warren Taylor; Fiscal Year: 2007
    ..Discussion: These findings will better describe the role of neural connectivity and striatofrontal dysfunction in geriatric depression. ..
  11. Cognitive reserve and age-related brain changes
    Adam Brickman; Fiscal Year: 2005
    ..Results from the study will provide important insights into the normal aging process and will yield valuable information towards understanding the underpinnings of age-associated pathologies. ..
  12. Vascular Depression: Longitudinal Changes
    Warren D Taylor; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  13. Neural Substrates of Component Lexical Semantic Processes
    BRIAN GOLD; Fiscal Year: 2008
    ..abstract_text> ..
  14. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2008
    ..abstract_text> ..
  15. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2008
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
  16. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  17. Huntington's Disease:Morphometry, Chemistry & Cognition
    HERMINIA ROSAS; Fiscal Year: 2002
    ..This work will advance our understanding of the functional consequences of the genetic mutation in HD and may lead to improvements in monitoring and treating the disease. ..
  18. Mouse Brain Development Study by MRI
    Susumu Mori; Fiscal Year: 2003
    ..abstract_text> ..
  19. Mechanisms of Radiation-Induced Cognitive Dysfunction
    William Brown; Fiscal Year: 2008
    ..Such therapeutic intervention studies could potentially be performed in as little as 10 weeks. ..
  20. IMAGING BRAIN MATURATION AND NEUROBEHAVIORAL CORRELATES
    ELIZABETH SOWELL; Fiscal Year: 2003
    ..g., verbal memory vs. spatial memory), and similar brain regions will be implicated in the fMRI studies of memory, and the sMRI/memory correlation studies. ..
  21. White Matter Change and CNS Process in the Elderly
    Lisa Silbert; Fiscal Year: 2008
    ..This application proposes a structured didactic mentorship program for the principal investigator, Dr. Lisa Silbert, to ensure her independence as a clinical investigator at the end of the 5-year award period. [unreadable] [unreadable]..
  22. Oxidative Stress and Nerve Pathology in Diabetes
    Andrew Mizisin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  23. Depolarization-induced Ca Stores Release in CNS Axons
    Peter Stys; Fiscal Year: 2006
    ..abstract_text> ..
  24. Two-Tensor Model Analysis for DTI
    Sharon Peled; Fiscal Year: 2007
    ..The method proposed herein optimizes the information available from DTI acquired in clinically feasible time frames. [unreadable] [unreadable] [unreadable]..
  25. Regulation of Oligodendrocyte Survival
    Horea Rus; Fiscal Year: 2006
    ..Our proposed studies will provide an unique model system to elucidate the biology of sublethally injured OLG and may lead to the identification of regulatory factors that can enhance OLG survival and remyelination. ..
  26. MR Microimaging of Alzheimer's Mouse Models
    Susumu Mori; Fiscal Year: 2005
    ..Hypothesis: The amyloid plaque detection and volume measurements can be achieved in vivo. To confirm these hypotheses, 2 mouse strains of the AD model will be studied at 4 different ages. ..
  27. MR-Based Study of Hypomyelination by Lead Poisoning
    Susumu Mori; Fiscal Year: 2007
    ..Using the MRI-based technique and normative database established under Aim 1 and 2, we will perform comprehensive myelination studies to examine the hypothesis [unreadable] [unreadable]..
  28. DtiStudio: Resource Software for Diffusion Tensor Imaging
    Susumu Mori; Fiscal Year: 2010
    ..This also provides an environment for open source. Aim 4: Upgrade to integrate new technologies. ..
  29. Cross-cultural FASD: Brain Imaging (U24 Core)
    ELIZABETH SOWELL; Fiscal Year: 2005
    ..abstract_text> ..
  30. Analyzing Functional and Structural MRI in FAS Children
    ELIZABETH SOWELL; Fiscal Year: 2004
    ..The results of these studies will help us in planning intervention strategies to optimize development in FAS children and provide more optimal image analysis techniques for other pediatric populations. ..
  31. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
    ..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..
  32. Seizures & Amydala-Based Socioemotional Dysfunction
    Ludise Malkova; Fiscal Year: 2007
    ..The team is ideally suited to approach the analysis of comorbidity of seizures and autistic-like symptoms evoked from amygdala and to permit a translationally meaningful analysis of the animal data. [unreadable] [unreadable] [unreadable]..
  33. Systemic perinatal insults disrupt neurodevelopment
    Shenandoah Robinson; Fiscal Year: 2008
    ..Insights into mechanisms underlying the disruption of perinatal neural development will lead to novel interventions to enhance neural development in neonates, and minimize neurologic deficits. ..
  34. Neuroanatomical endophenotypes in Persistent Developmental Stuttering
    Matthew Cykowski; Fiscal Year: 2008
    ..Understanding the genetic basis of the disorder will help improve diagnostic approaches and treatment strategies. [unreadable] [unreadable] [unreadable]..
  35. Role of Intraspinal Plasticity in Autonomic Dysreflexia
    Alexander Rabchevsky; Fiscal Year: 2008
    ..This information will form the basis for developing potential treatments for this common and debilitating complication of SCI. ..
  36. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  37. Novel Therapy for Multiple Sclerosis (SBIR-Phase II)
    Feng Qiao Li; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Functional Architecture of Developmental Brain Disorder
    Bernard Chang; Fiscal Year: 2008
    ..By combining training in these two areas, the candidate will gain the experience and skills necessary to transition to an independent career in clinical neuroscience research. [unreadable] [unreadable]..
  39. Anatomical Connectivity in the Autistic Brain
    Mariana Lazar; Fiscal Year: 2008
    ..Knowledge of the impaired brain connectivity will provide new insights into the mechanisms that underlie brain disfunction in autism. [unreadable] [unreadable] [unreadable]..
  40. Presynaptic Mechanisms of Neurotransmission in NTS
    MICHAEL ANDRESEN; Fiscal Year: 2009
    ..The different sub classes of afferent nerve terminal will be also be compared in terms of their control of glutamate release and modulation by peptides. ..
  41. Bladder and Sphincter Control after Spinal Cord Injury
    Changfeng Tai; Fiscal Year: 2008
    ..abstract_text> ..
  42. Locomotion Control by Lumbar Spinal Cord Stimulation
    Changfeng Tai; Fiscal Year: 2008
    ..The proposed studies will not only improve our understanding of locomotion control in lumbar spinal cord but also benefit SCI patients. ..
  43. The role of gender on post-traumatic inflammation
    Helen Bramlett; Fiscal Year: 2006
    ..Established methods including rodent models of TBI, behavioral tests, as well as immunocytochemical and molecular approaches will be used in this proposal. ..
  44. Normal Human and Schizophrenic Brain
    Manuel Casanova; Fiscal Year: 2004
    ..Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization. ..
  45. Postdoctoral Training Program in Neural Regeneration
    Oswald Steward; Fiscal Year: 2005
    ....
  46. An fMRI Study of Executive Functioning after TBI
    Harvey Levin; Fiscal Year: 2005
    ..Analyses will test TBI-related alterations in brain activation at 3 months postinjury, changes on reimaging at 1 year, relationship to EFs, and MPH effects. ..
  47. GROWTH FACTOR ENHANCED RETROVIRAL GENE TRANSFER TO CNS
    RAYMOND COLELLO; Fiscal Year: 2003
    ..It is hoped that these proposed experiments will lead to a new generation of studies designed to broaden the application of MLV vectors to include other neurodegenerative disease models of the CNS. ..
  48. MR Spectroscopy of Amyotrophic Lateral Sclerosis
    Lana Kaiser; Fiscal Year: 2004
    ..The hypothesis that Glu is elevated in motor cortex region of the brain in ALS patients will be tested and the possibility of using Glu elevation as a surrogate marker of ALS will be investigated. ..
  49. FACILITY RENOVATION AND ANNENBERG CAGE WASH FACILITIY
    Kenneth Davis; Fiscal Year: 2003
    ..e. soiled nonhuman primate cages). ..
  50. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  51. TISSUE CHARACTERIZATION WITH SLAB SCAN DIFFUSIION MRI
    Stephan Maier; Fiscal Year: 2002
    ..The study, therefore, proposes direct applications of basic research to clinical situations demanding the highest possible sensitivity and specific for invasive treatment of other therapeutic decisions. ..
  52. Opioids Modulate Oligodendrocyte Development & Function
    Pamela Knapp; Fiscal Year: 2006
    ..Techniques used include cell culture, immunostaining, in situ hybridization, immunoblot, confocal microscopy and adenoviral transfection. ..
  53. The Role of Feedback to Facilitate Category Learning
    Deborah Little; Fiscal Year: 2005
    ..Finally, we propose to collect pilot data functional MRI data, on the conditions under which prefrontal cortex is implicated during prototype-distortion learning in response to feedback. ..
  54. Reward-Motivated Learning in Adolescent Cannabis Users
    Leslie Jacobsen; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Divalproex sodium and Risperidone in Pediatric Bipolar Disorder
    Mani Pavuluri; Fiscal Year: 2007
    ..During five years, 40 outpatient subjects with PBD manic or mixed episodes, ages 8-17 years, referred to the UI Pediatric Mood Disorder Clinic will be recruited. ..
  56. CENTRAL BAROREFLEX MECHANISMS OF ANESTHETIC ACTION
    MICHAEL ANDRESEN; Fiscal Year: 2006
    ..By examining different anesthetics, we may also better understand whether potentially new anesthetics might be designed to spare these cardioregulatory sites. [unreadable] [unreadable]..
  57. Global vs. Focal Neuroimaging Markers of Dementia Risk
    Caterina Rosano; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  58. Nestin: A Putative Marker of a Mammary Stem and Progenitor Cell Lineage
    Teresa Wood; Fiscal Year: 2007
    ..This novel marker may identify a population of undifferentiated breast tumor stem or progenitor cells. [unreadable] [unreadable] [unreadable]..
  59. Cerebral Vasoregulation In Elderly with Stroke
    Vera Novak; Fiscal Year: 2007
    ..The results of this study may improve our understanding of optimal BP targets for the maintenance of cerebral perfusion in elderly people with stroke. ..
  60. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  61. Facilitators of Motor Recovery Following Stroke
    Gottfried Schlaug; Fiscal Year: 2007
    ..abstract_text> ..