lewy bodies

Summary

Summary: Intracytoplasmic, eosinophilic, round to elongated inclusions found in vacuoles of injured or fragmented neurons. The presence of Lewy bodies is the histological marker of the degenerative changes in LEWY BODY DISEASE and PARKINSON DISEASE but they may be seen in other neurological conditions. They are typically found in the substantia nigra and locus coeruleus but they are also seen in the basal forebrain, hypothalamic nuclei, and neocortex.

Top Publications

  1. ncbi Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
    I G McKeith
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 65:1863-72. 2005
  2. doi Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Nat Med 14:501-3. 2008
  3. ncbi Staging of brain pathology related to sporadic Parkinson's disease
    Heiko Braak
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Neurobiol Aging 24:197-211. 2003
  4. doi Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences and Center for Brain Repair, Rush University Medical Center, 1735 West Harrison Street, Chicago, Illinois 60612, USA
    Nat Med 14:504-6. 2008
  5. pmc Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    Kelvin C Luk
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, Philadelphia, PA 19104 4283, USA
    Proc Natl Acad Sci U S A 106:20051-6. 2009
  6. pmc Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
    Laura A Volpicelli-Daley
    Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA
    Neuron 72:57-71. 2011
  7. pmc alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    M G Spillantini
    Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, Cambridge CB2 2PY, United Kingdom
    Proc Natl Acad Sci U S A 95:6469-73. 1998
  8. ncbi Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    Michael L Kramer
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, 37075 Goettingen, Germany
    J Neurosci 27:1405-10. 2007
  9. ncbi Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
    H I Hurtig
    Department of Neurology, University of Pennsylvania, PA, USA
    Neurology 54:1916-21. 2000
  10. ncbi Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
    K K Chung
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 7:1144-50. 2001

Research Grants

  1. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2011
  2. Katherine P Rankin; Fiscal Year: 2016
  3. Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
    David Alan Bennett; Fiscal Year: 2013
  4. Indicators of early neurodegeneration: gene-toxin interactions at the syanpse
    Felix E Schweizer; Fiscal Year: 2010
  5. Alpha-Synuclein-Metal Complexes and Oxidative Stress in Parkinson's Disease
    Feimeng Zhou; Fiscal Year: 2012
  6. R Lee Mosley; Fiscal Year: 2014
  7. Radiolabled MAO-B Substrates for Imaging
    Michael R Kilbourn; Fiscal Year: 2012
  8. High Sensitivity Mobile PET for Brain Imaging and Proton Therapy Monitoring
    Georges El Fakhri; Fiscal Year: 2010
  9. Cognitive Decline and Dementia: Life Experiences and the Brain Histone Epigenome
    David A Bennett; Fiscal Year: 2010
  10. Lei Yu; Fiscal Year: 2015

Detail Information

Publications334 found, 100 shown here

  1. ncbi Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium
    I G McKeith
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Neurology 65:1863-72. 2005
    The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them...
  2. doi Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, 221 84 Lund, Sweden
    Nat Med 14:501-3. 2008
    ..of transplanted fetal mesencephalic dopaminergic neurons (11-16 years) developed alpha-synuclein-positive Lewy bodies in grafted neurons...
  3. ncbi Staging of brain pathology related to sporadic Parkinson's disease
    Heiko Braak
    Department of Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, D 60590 Frankfurt Main, Germany
    Neurobiol Aging 24:197-211. 2003
    ..Essential for neuropathological diagnosis are alpha-synuclein-immunopositive Lewy neurites and Lewy bodies. The pathological process targets specific induction sites: lesions initially occur in the dorsal motor nucleus ..
  4. doi Lewy body-like pathology in long-term embryonic nigral transplants in Parkinson's disease
    Jeffrey H Kordower
    Department of Neurological Sciences and Center for Brain Repair, Rush University Medical Center, 1735 West Harrison Street, Chicago, Illinois 60612, USA
    Nat Med 14:504-6. 2008
    ..These findings have implications for cell-based therapies and for understanding the cause of Parkinson's disease...
  5. pmc Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    Kelvin C Luk
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, Philadelphia, PA 19104 4283, USA
    Proc Natl Acad Sci U S A 106:20051-6. 2009
    Cytoplasmic inclusions containing alpha-synuclein (alpha-Syn) fibrils, referred to as Lewy bodies (LBs), are the signature neuropathological hallmarks of Parkinson's disease (PD)...
  6. pmc Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death
    Laura A Volpicelli-Daley
    Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 USA
    Neuron 72:57-71. 2011
    Inclusions composed of α-synuclein (α-syn), i.e., Lewy bodies (LBs) and Lewy neurites (LNs), define synucleinopathies including Parkinson's disease (PD) and dementia with Lewy bodies (DLB)...
  7. pmc alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies
    M G Spillantini
    Medical Research Council Centre for Brain Repair and Department of Neurology, University of Cambridge, Robinson Way, Cambridge CB2 2PY, United Kingdom
    Proc Natl Acad Sci U S A 95:6469-73. 1998
    b>Lewy bodies and Lewy neurites are the defining neuropathological characteristics of Parkinson's disease and dementia with Lewy bodies. They are made of abnormal filamentous assemblies of unknown composition...
  8. ncbi Presynaptic alpha-synuclein aggregates, not Lewy bodies, cause neurodegeneration in dementia with Lewy bodies
    Michael L Kramer
    Prion and Dementia Research Unit, Institute of Neuropathology, University of Goettingen, 37075 Goettingen, Germany
    J Neurosci 27:1405-10. 2007
    b>Lewy bodies, the pathological hallmark of dementia with Lewy bodies (DLB), are large juxtanuclear inclusions of aggregated alpha-synuclein...
  9. ncbi Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's disease
    H I Hurtig
    Department of Neurology, University of Pennsylvania, PA, USA
    Neurology 54:1916-21. 2000
    ..Although Alzheimer's pathology has been a frequent finding, recent advances in immunostaining of alpha-synuclein have suggested the possible importance of cortical Lewy bodies (CLBs) in the brains of demented patients with PD.
  10. ncbi Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease
    K K Chung
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Nat Med 7:1144-50. 2001
    ..by the loss of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated inclusions (Lewy bodies). Mutations in alpha-synuclein (A53T, A30P) and parkin cause familial Parkinson disease...
  11. ncbi Proteomic identification of novel proteins in cortical lewy bodies
    James B Leverenz
    Department of Neurology, School of Medicine, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 17:139-45. 2007
    Lewy body (LB) inclusions are one of the pathological hallmarks of Parkinson's disease (PD) and dementia with Lewy bodies (DLB)...
  12. ncbi Ubiquitination of alpha-synuclein and autophagy in Parkinson's disease
    Simone Engelender
    Department of Pharmacology, The B Rappaport Faculty of Medicine and Institute of Medical Research, Technion Israel Institute of Technology, Haifa, Israel
    Autophagy 4:372-4. 2008
    alpha-Synuclein is mutated in Parkinson's disease (PD) and is found in cytosolic inclusions, called Lewy bodies, in sporadic forms of the disease...
  13. ncbi Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells
    Wanli W Smith
    Department of Psychiatry, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 25:5544-52. 2005
    ..is a neurodegenerative disorder characterized by selective loss of dopaminergic neurons and the presence of Lewy bodies. Previous reports have shown that alpha-synuclein deposited in brain tissue from individuals with ..
  14. pmc In vitro high affinity alpha-synuclein binding sites for the amyloid imaging agent PIB are not matched by binding to Lewy bodies in postmortem human brain
    Liang Ye
    GlaxoSmithKline, Clinical Science and Technology, Neurology DM, New Frontiers Science Park, Harlow, UK
    J Neurochem 105:1428-37. 2008
    ..was detected with amygdala sections from Parkinson's disease cases containing frequent AS-immunoreactive Lewy bodies and related neurities...
  15. pmc Proteomic identification of novel proteins associated with Lewy bodies
    Qiangwei Xia
    Department of Human Genetics, The Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Front Biosci 13:3850-6. 2008
    The manifestation of Lewy bodies (LB) in the brain is a hallmark of Parkinson's disease. Here, we present a comprehensive analysis of protein elements in Lewy bodies by comparative mass spectrometry...
  16. pmc Alpha-synuclein cell-to-cell transfer and seeding in grafted dopaminergic neurons in vivo
    Elodie Angot
    Neuronal Survival Unit, Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    PLoS ONE 7:e39465. 2012
    ..Following autopsy, 10-22 years after surgery, some of the grafted neurons contained Lewy bodies similar to those observed in the host brain...
  17. pmc Granular assembly of alpha-synuclein leading to the accelerated amyloid fibril formation with shear stress
    Ghibom Bhak
    School of Chemical and Biological Engineering, College of Engineering, Seoul National University, Gwanak ku, Seoul, Korea
    PLoS ONE 4:e4177. 2009
    ....
  18. ncbi Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease
    Pavan K Auluck
    Department of Neuroscience, University of Pennsylvania and University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 295:865-8. 2002
    ..a protein implicated in the pathogenesis of Parkinson's disease and a major component of proteinaceous Lewy bodies. We report that directed expression of the molecular chaperone Hsp70 prevented dopaminergic neuronal loss ..
  19. ncbi Proteasomal inhibition by alpha-synuclein filaments and oligomers
    Evo Lindersson
    Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark
    J Biol Chem 279:12924-34. 2004
    ..We demonstrate that alpha-synuclein and 20 S proteasome components co-localize in Lewy bodies and show that subunits from 20 S proteasome particles, in contrast to subunits of the 19 S regulatory complex, ..
  20. pmc Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2
    João Paulo L Daher
    Neuroregeneration and Stem Cell Programs, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Hum Mol Genet 21:2420-31. 2012
    ..Fibrillar forms of α-synuclein are a major component of Lewy bodies, the intracytoplasmic proteinaceous inclusions that are a pathological hallmark of idiopathic and certain ..
  21. ncbi Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    E Masliah
    Department of Neurosciences, Department of Pathology, University of California San Diego, La Jolla, CA 92093 0624, USA
    Science 287:1265-9. 2000
    ..These results suggest that accumulation of wild-type alpha-synuclein may play a causal role in Parkinson's disease and related conditions...
  22. doi Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
    Jia Yi Li
    Neuronal Survival Unit, Wallenberg Neuroscience Center, Lund University, Lund, Sweden
    Mov Disord 25:1091-6. 2010
    We previously reported the occurrence of Lewy bodies in grafted human fetal mesencephalic neurons in two patients with Parkinson's disease...
  23. doi Neuropathology of non-motor features of Parkinson disease
    Dennis W Dickson
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Parkinsonism Relat Disord 15:S1-5. 2009
    ..signs in PD are tightly linked to striatonigral dopaminergic denervation associated with neuronal loss and Lewy bodies in the residual neurons of the substantia nigra...
  24. ncbi Development of alpha-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson's disease
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Theodor Stern Kai 7, 60590, Frankfurt am Main, Germany
    Acta Neuropathol 114:231-41. 2007
    ..distribution pattern of these astrocytes closely parallels that of the cortical intraneuronal Lewy neurites and Lewy bodies, which, from their foothold in the mesocortex, gradually encroach upon neocortical association areas and even ..
  25. pmc Transfer of host-derived α synuclein to grafted dopaminergic neurons in rat
    Jeffrey H Kordower
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    Neurobiol Dis 43:552-7. 2011
    Multiple laboratories have recently demonstrated that long-term dopaminergic transplants form Lewy bodies in patients with Parkinson's disease...
  26. pmc Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy
    Zuzana Walker
    University College London and Royal Free Hospitals, London, UK
    J Neurol Neurosurg Psychiatry 78:1176-81. 2007
    Dementia with Lewy bodies (DLB) is a common form of dementia. The presence of Alzheimer's disease (AD) pathology modifies the clinical features of DLB, making it harder to distinguish DLB from AD clinically during life...
  27. pmc Association of glucocerebrosidase mutations with dementia with lewy bodies
    Lorraine N Clark
    Taub Institute for Research onAlzheimer s Disease and the Aging Brain, Columbia University, New York, NY 10032, USA
    Arch Neurol 66:578-83. 2009
    ..Mutations in the glucocerebrosidase (GBA) gene are associated with Lewy body (LB) disorders...
  28. ncbi The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways
    Youngah Shin
    Alzheimer Disease Research Unit, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Biol Chem 280:23727-34. 2005
    Alpha-synuclein is a major component of Lewy bodies, the pathological hallmark of Parkinson disease, dementia with Lewy bodies, and related disorders...
  29. ncbi A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death
    Yuzuru Imai
    Laboratory for Motor System Neurodegeneration, RIKEN Brain Science Institute, Saitama 351 0198, Japan
    J Biol Chem 278:51901-10. 2003
    ..Moreover, Glup turned out to be a component of Lewy bodies in Parkinson's disease cases...
  30. doi MAPT H1 haplotype is associated with enhanced α-synuclein deposition in dementia with Lewy bodies
    Martí Colom-Cadena
    Neurology Department, Institut d Investigacions Biomèdiques Sant Pau, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain
    Neurobiol Aging 34:936-42. 2013
    ..haplotypes and pathologic aggregates of tau and α-synuclein in pathologically confirmed cases of dementia with Lewy bodies (DLB). Twenty-two cases fulfilling clinical and neuropathological criteria for DLB were included...
  31. ncbi Progression and staging of Lewy pathology in brains from patients with dementia with Lewy bodies
    Wami Marui
    Department of Psychiatry, Yokohama City University School of Medicine, 3 9 Fukuura, Yokohama 236 0004, Kanazawa, Japan
    J Neurol Sci 195:153-9. 2002
    Using alpha-synuclein-immunohistochemistry, 27 brains of dementia with Lewy bodies (DLB) were investigated to identify the progression of Lewy pathology including Lewy bodies (LB) and LB-related neurites in the cerebrum...
  32. pmc Visual cortex in dementia with Lewy bodies: magnetic resonance imaging study
    John Paul Taylor
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, UK
    Br J Psychiatry 200:491-8. 2012
    Visual hallucinations and visuoperceptual deficits are common in dementia with Lewy bodies, suggesting that cortical visual function may be abnormal.
  33. pmc Cognitive impairment, decline and fluctuations in older community-dwelling subjects with Lewy bodies
    J A Schneider
    Rush Alzheimer s Disease Centre, Rush University Medical Centre, Chicago, IL 60612, USA
    Brain 135:3005-14. 2012
    b>Lewy bodies are common in the ageing brain and often co-occur with Alzheimer's disease pathology...
  34. pmc Visual hallucinations in dementia with Lewy bodies: transcranial magnetic stimulation study
    John Paul Taylor
    Institute for Ageing and Health, Newcastle University, Wolfson Research Centre, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK
    Br J Psychiatry 199:492-500. 2011
    The aetiology of visual hallucinations is poorly understood in dementia with Lewy bodies. Pathological alterations in visual cortical excitability may be one contributory mechanism.
  35. ncbi Alpha-synuclein: normal function and role in neurodegenerative diseases
    Erin H Norris
    Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Curr Top Dev Biol 60:17-54. 2004
    ..that characterize many neurodegenerative disorders, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and neurodegeneration with brain iron accumulation type 1 (NBIA-1), which collectively are termed ..
  36. pmc Ubiquitin ligase Nedd4 promotes alpha-synuclein degradation by the endosomal-lysosomal pathway
    George K Tofaris
    Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:17004-9. 2011
    ..human brains, Nedd4 is present in pigmented neurons and is expressed especially strongly in neurons containing Lewy bodies. Thus, ubiquitination by Nedd4 targets α-synuclein to the endosomal-lysosomal pathway and, by reducing α-..
  37. ncbi Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)
    Heiko Braak
    Institute for Clinical Neuroanatomy, J W Goethe University, Frankfurt Main, Germany
    J Neurol 249:III/1-5. 2002
    ..IPD manifests itself in all of its dimensions, which under the influence of the supervening cortical pathology are subject to increasing complexity...
  38. doi DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes
    P F Durrenberger
    University Department of Neuropathology, Imperial College, University of London, and Hammersmith Hospitals Trust, London, United Kindom
    J Neurosci Res 87:238-45. 2009
    ..2006] Neurogenetics 7:1-11). We now show that DnaJB6 is a novel component of Lewy bodies (LBs) in both PD substantia nigra and PD cortex and that it is strongly up-regulated in parkinsonian astrocytes...
  39. ncbi Adult-onset neurodegeneration with brain iron accumulation and cortical alpha-synuclein and tau pathology: a distinct clinicopathological entity
    George K Tofaris
    Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, Institute of Child Health and Great Ormond Street Hospital, London, England, UK
    Arch Neurol 64:280-2. 2007
    ..Familial cases with mutations in the pantothenate kinase gene are associated with a specific phenotype. In contrast, sporadic cases are heterogeneous in their clinical presentation...
  40. doi Localization of MAP1-LC3 in vulnerable neurons and Lewy bodies in brains of patients with dementia with Lewy bodies
    Shinji Higashi
    PET CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Shinsuna, Koto ku, Tokyo, Japan
    J Neuropathol Exp Neurol 70:264-80. 2011
    ..alterations of autophagy-lysosome pathway-related proteins in the brains of patients with dementia with Lewy bodies (DLB), Alzheimer disease (AD), and control subjects using antibodies against Ras-related protein Rab-7B (Rab7B),..
  41. doi Who was the man who discovered the "Lewy bodies"?
    Antonio M Rodrigues e Silva
    Department of Neurology, Philipps University, Marburg, Germany
    Mov Disord 25:1765-73. 2010
    ..e., Parkinson's disease). Later, these findings became the so-called "Lewy bodies." However, little is known about the man who made this discovery...
  42. ncbi Restricted occurrence of Lewy bodies in the dorsal vagal nucleus in a patient with late-onset parkinsonism
    K Wakabayashi
    Brain Disease Research Center, Brain Research Institute, Niigata University, Japan
    J Neurol Sci 165:188-91. 1999
    ..Despite the use of ubiquitin and alpha-synuclein immunohistochemistry, no further LBs were identified in other brain regions. These findings suggest that this case was an unusual, anatomically restricted manifestation of LB disease...
  43. ncbi alpha-Synuclein is phosphorylated in synucleinopathy lesions
    Hideo Fujiwara
    Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Cell Biol 4:160-4. 2002
    ..These disorders include Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy, collectively referred to as synucleinopathies...
  44. pmc Tissue transglutaminase-induced aggregation of alpha-synuclein: Implications for Lewy body formation in Parkinson's disease and dementia with Lewy bodies
    Eunsung Junn
    Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1406, USA
    Proc Natl Acad Sci U S A 100:2047-52. 2003
    ..alpha-synuclein represent a feature of neurodegenerative disorders such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy...
  45. ncbi Pael-R is accumulated in Lewy bodies of Parkinson's disease
    Tetsuro Murakami
    Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Ann Neurol 55:439-42. 2004
    ..Pael-R, Parkin, alpha-synuclein, and ubiquitin accumulated in Lewy bodies (LBs) and neurites. Pael-R was localized in the core of LBs...
  46. ncbi Morphogenesis of Lewy bodies: dissimilar incorporation of alpha-synuclein, ubiquitin, and p62
    Erkki Kuusisto
    Department of Neuroscience and Neurology, University of Kuopio, Kuopio, Finland
    J Neuropathol Exp Neurol 62:1241-53. 2003
    The formation of Lewy bodies (LBs) and their relationship to other types of nigral inclusions associated with Parkinson disease (PD), such as pale bodies (PBs), remain poorly understood...
  47. pmc Lewy bodies
    Clifford W Shults
    Department of Neurosciences, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 103:1661-8. 2006
    b>Lewy bodies (LB) in the substantia nigra are a cardinal pathological feature of Parkinson's disease, but they occur in a number of neurodegenerative diseases and can be widespread in the nervous system...
  48. doi Neurotransmitter changes in dementia with Lewy bodies and Parkinson disease dementia in vivo
    J C Klein
    Department of Neurology, Goethe University, Frankfurt am Main, Germany
    Neurology 74:885-92. 2010
    Although Parkinson disease with dementia (PDD) and dementia with Lewy bodies (DLB) show a wide clinical and neuropathologic overlap, they are differentiated according to the order and latency of cognitive and motor symptom appearance...
  49. doi Emerging pathways in genetic Parkinson's disease: tangles, Lewy bodies and LRRK2
    Michael J Devine
    Department of Clinical Neuroscience, Imperial College London, UK
    FEBS J 275:5748-57. 2008
    ..This minireview explores this model, in the context of our current understanding of the biochemistry of LRRK2, alpha-synuclein and tau...
  50. ncbi Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life
    B Joy Snider
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 62:1821-30. 2005
    ..We describe herein a kindred with very early-onset FAD (age, <40 years) with unusual pathological features and a novel mutation in the presenilin 1 (PSEN1) gene (S170F) and review the existing literature on very early-onset FAD...
  51. pmc Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
    James A Olzmann
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 178:1025-38. 2007
    ..Mutations in the E3 ligase parkin cause autosomal recessive Parkinson's disease that is devoid of Lewy bodies, which are similar to aggresomes...
  52. pmc White matter lesions on magnetic resonance imaging in dementia with Lewy bodies, Alzheimer's disease, vascular dementia, and normal aging
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    J Neurol Neurosurg Psychiatry 67:66-72. 1999
    ..The aims were to investigate whether white matter changes also occur in dementia with Lewy bodies and to examine the relation between white matter lesions and the cognitive and non-cognitive features of ..
  53. ncbi alpha-Synuclein is colocalized with 14-3-3 and synphilin-1 in A53T transgenic mice
    Yoshitomo Shirakashi
    Department of Neurology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto, 606 8507, Japan
    Acta Neuropathol 112:681-9. 2006
    alpha-Synuclein is a major constituent of Lewy bodies, the neuropathological hallmark of Parkinson's disease (PD). Three types of alpha-synuclein mutations, A53T, A30P, and E46K, have been reported in familial PD...
  54. ncbi Medial temporal lobe atrophy on MRI in dementia with Lewy bodies
    R Barber
    Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, UK
    Neurology 52:1153-8. 1999
    To investigate whether medial temporal lobe atrophy (MTA) on MRI is less frequent in dementia with Lewy bodies (DLB) compared with AD and vascular dementia (VaD), and to determine the diagnostic utility of MTA in the differential ..
  55. ncbi Protein aggregation in the pathogenesis of familial and sporadic Parkinson's disease
    Kevin St P McNaught
    Department of Neurology, Mount Sinai School of Medicine, Annenberg 14 73, One Gustave L Levy Place, New York, NY 10029, USA
    Neurobiol Aging 27:530-45. 2006
    ..This suggests that manipulation of proteolytic systems is a rational approach in the development of neuroprotective therapies that could modify the pathological course of PD...
  56. pmc Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes
    C F Lippa
    Department of Neurology, Allegheny University of the Health Sciences MCP Division, Philadelphia, Pennsylvania 19129, USA
    Am J Pathol 153:1365-70. 1998
    ..the alpha-synuclein gene cause familial Parkinson's disease (PD), and alpha-synuclein is a major component of Lewy bodies (LBs) in sporadic PD, dementia with LBs (DLB), and the LB variant of Alzheimer's disease (AD)...
  57. ncbi Investigation of Lewy pathology in the visual pathway of brains of dementia with Lewy bodies
    Ryoko Yamamoto
    Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, 3 3 20 Shinsuna, Koto ku, Tokyo 136 0075, Japan
    J Neurol Sci 246:95-101. 2006
    We examined 19 autopsied cases of dementia with Lewy bodies (DLB) using pathological and alpha-synuclein-immunohistochemical methods, and investigated Lewy pathology in the primary visual pathway (lateral geniculate body and Brodmann's ..
  58. ncbi A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
    B I Giasson
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Neurosci Res 59:528-33. 2000
    ..Since alpha-synuclein has been reported to be a major component of Lewy bodies (LBs) in Parkinson's disease (PD), dementia with LBs and common variants of Alzheimer's disease, we performed ..
  59. doi Pathological roles of α-synuclein in neurological disorders
    Kostas Vekrellis
    Biomedical Research Foundation of Academy of Athens, Athens, Greece
    Lancet Neurol 10:1015-25. 2011
    ..Consequently, factors that regulate the levels, post-translational modifications, specific aberrant cellular effects, or secretion of α-synuclein might be targets for therapy...
  60. ncbi The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
    Frank P Marx
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    FASEB J 21:1759-67. 2007
    ..protein and substrate of the ubiquitin E3 ligase Parkin (PARK2) and because of its presence in Lewy bodies (LB) in brains of PD patients...
  61. doi Three-layered structure shared between Lewy bodies and lewy neurites-three-dimensional reconstruction of triple-labeled sections
    Toshiro Kanazawa
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 18:415-22. 2008
    b>Lewy bodies (LBs) and Lewy neurites (LNs) are the hallmarks of Parkinson's disease (PD)...
  62. ncbi Lewy bodies in Parkinson's disease: protectors or perpetrators?
    Timothy P Harrower
    Cambridge Centre for Brain Repair, Robinson Way, Cambridge CB22PY, UK
    Exp Neurol 195:1-6. 2005
  63. ncbi Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
    Cecilia Gotti
    CNR, Institute of Neuroscience, Cellular and Molecular Pharmacology Section, Department of Medical Pharmacology and Center of Excellence on Neurodegenerative Diseases, University of Milan, Italy
    Neurobiol Dis 23:481-9. 2006
    ..Minimal binding (< or =5%) was associated with alpha3. In Alzheimer's disease and dementia with Lewy bodies, cortical loss of binding was associated with reductions in alpha4 (50%, P < 0...
  64. ncbi The Lewy body in Parkinson's disease: molecules implicated in the formation and degradation of alpha-synuclein aggregates
    Koichi Wakabayashi
    Department of Neuropathology, Institute of Brain Science, Hirosaki University School of Medicine, Hirosaki, Japan
    Neuropathology 27:494-506. 2007
    The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates called Lewy bodies (LBs)...
  65. ncbi Widespread expression of alpha-synuclein and tau immunoreactivity in Hallervorden-Spatz syndrome with protracted clinical course
    Y Saito
    Department of Neurology, Division of Neuroscience, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Neurol Sci 177:48-59. 2000
    ..diffuse sponginess in the atrophic cortex as well as widespread Alzheimer's neurofibrillary tangles (NFTs) and Lewy bodies (LBs) in the cortical and subcortical regions, including the spinal cord...
  66. ncbi Pathological entity of dementia with Lewy bodies and its differentiation from Alzheimer's disease
    Wami Marui
    Department of Psychiatry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, 236 0004, Yokohama, Japan
    Acta Neuropathol 108:121-8. 2004
    We reclassified the pathological subtypes of dementia with Lewy bodies (DLB), based on both Lewy pathology and Alzheimer pathology, to clarify the pathological entity of DLB and the boundary between DLB and Alzheimer's disease (AD) in ..
  67. ncbi Dementia with Lewy bodies and Parkinson's disease with dementia: are they different?
    Yoshio Tsuboi
    Fifth Department of Internal Medicine, Fukuoka University, Japan
    Parkinsonism Relat Disord 11:S47-51. 2005
    The relationship of dementia with Lewy bodies (DLB) and Parkinson's disease with dementia (PDD) is debated. In DLB, dementia antedates Parkinsonism; in PDD, Parkinsonism antedates dementia...
  68. ncbi Research evaluation and prospective diagnosis of dementia with Lewy bodies
    Oscar L Lopez
    Alzheimer s Disease Research Center, University of Pittsburgh, PA, USA
    Arch Neurol 59:43-6. 2002
    To evaluate the relative merits of recently developed criteria for dementia with Lewy bodies (DLBs) in a longitudinal study of dementia.
  69. ncbi Microtubule-associated protein 1B is a component of cortical Lewy bodies and binds alpha-synuclein filaments
    P H Jensen
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus C, Denmark, Arpida AG, Munchenstein 4142, Switzerland
    J Biol Chem 275:21500-7. 2000
    b>Lewy bodies, neuropathological hallmarks of Parkinson's disease and dementia with Lewy bodies, comprise alpha-synuclein filaments and other less defined proteins...
  70. ncbi Enhanced lysosomal pathology caused by beta-synuclein mutants linked to dementia with Lewy bodies
    JianShe Wei
    Laboratory for Chemistry and Metabolism, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, Japan
    J Biol Chem 282:28904-14. 2007
    ..V70M) of beta-synuclein (beta-syn), the homologue of alpha-syn, have been recently identified in dementia with Lewy bodies. However, the mechanism through which these mutations influence the pathogenesis of dementia with Lewy bodies ..
  71. ncbi Adult polyglucosan body disease associated with lewy bodies and tremor
    Jaya R Trivedi
    Department of Neurology, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Arch Neurol 60:764-6. 2003
    ..Extrapyramidal features are unusual in PGBD and are presumed secondary to widespread pathology that includes the basal ganglia. There are no prior reports of Lewy bodies in PGBD.
  72. pmc Structured regions of α-synuclein fibrils include the early-onset Parkinson's disease mutation sites
    Gemma Comellas
    Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, 600 South Mathews Avenue, Urbana, IL 61801, USA
    J Mol Biol 411:881-95. 2011
    Synuclein (AS) fibrils are the major component of Lewy bodies, the pathological hallmark of Parkinson's disease (PD)...
  73. pmc Identification of protein interfaces between α-synuclein, the principal component of Lewy bodies in Parkinson disease, and the molecular chaperones human Hsc70 and the yeast Ssa1p
    Virginie Redeker
    Laboratoire d Enzymologie et Biochimie Structurales, CNRS, 91198 Gif sur Yvette, France
    J Biol Chem 287:32630-9. 2012
    Fibrillar α-synuclein (α-Syn) is the principal component of Lewy bodies, which are evident in individuals affected by Parkinson disease (PD)...
  74. ncbi Fully automatic differential diagnosis system for dementia with Lewy bodies and Alzheimer's disease using FDG-PET and 3D-SSP
    Atsushi K Kono
    Department of Radiology and Nuclear Medicine, Hyogo Brain and Heart Center, 520 Saisho Ko, Himeji, Hyogo, 670 0981, Japan
    Eur J Nucl Med Mol Imaging 34:1490-7. 2007
    To evaluate a fully automatic computer-assisted diagnostic system for mild dementia with Lewy bodies (DLB), permitting distinction from mild Alzheimer's disease (AD).
  75. doi The parkin-like human homolog of Drosophila ariadne-1 (HHARI) can induce aggresome formation in mammalian cells and is immunologically detectable in Lewy bodies
    Sangram S Parelkar
    Molecular and Cellular Biology Program, University of Massachusetts, Amherst, MA 01003, USA
    J Mol Neurosci 46:109-21. 2012
    ..In addition, endogenous HHARI is found in human Lewy bodies in both Parkinson's disease and diffuse Lewy body disorder...
  76. ncbi Thalamic D2 receptors in dementia with Lewy bodies, Parkinson's disease, and Parkinson's disease dementia
    Margaret A Piggott
    IAH Research Laboratories, Institute for Ageing and Health, University of Newcastle upon Tyne, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, UK
    Int J Neuropsychopharmacol 10:231-44. 2007
    Dementia with Lewy bodies (DLB) is characterized by progressive dementia with two of three core symptoms; Parkinsonism, visual hallucinations or disturbances of consciousness/fluctuating attention...
  77. ncbi Autonomic failure as the initial presentation of Parkinson disease and dementia with Lewy bodies
    Horacio Kaufmann
    Department of Neurology, Mount Sinai School of Medicine, Box 1052, New York, NY 10029, USA
    Neurology 63:1093-5. 2004
    ..postmortem neuropathologic findings of two patients, one with Parkinson disease (PD) and one with dementia with Lewy bodies (DLB), both of whom initially sought treatment for isolated autonomic failure...
  78. pmc Cell type specific sequestration of choline acetyltransferase and tyrosine hydroxylase within Lewy bodies
    Brittany N Dugger
    Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Acta Neuropathol 120:633-9. 2010
    b>Lewy bodies (LBs), the pathological hallmark of Lewy body disease (LBD), contain α-synuclein, as well as other proteins...
  79. doi Brain stem pathology in Parkinson's disease: an evaluation of the Braak staging model
    Ann E Kingsbury
    Reta Lila Weston Institute of Neurological Studies, UCL, Institute of Neurology, London, United Kingdom
    Mov Disord 25:2508-15. 2010
    ..These findings broadly support the Braak hypothesis of caudo-rostral development but indicate that the extent of the disease in the cortex and the severity of pathology in the medulla were independent of one another...
  80. ncbi A novel presenilin mutation (M233V) causing very early onset Alzheimer's disease with Lewy bodies
    H Houlden
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA
    Neurosci Lett 313:93-5. 2001
    ..This mutation causes disease with an exceptionally early onset age (approximately 30 years) in which pathological examination shows extensive Lewy bodies as well as plaques and tangles.
  81. pmc Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
    Paula Desplats
    Department of Neurosciences and Pathology, School of Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:13010-5. 2009
    ..These findings demonstrate the cell-to-cell transmission of alpha-synuclein aggregates and provide critical insights into the mechanism of pathological progression in PD and other proteinopathies...
  82. doi Neurogenic marker abnormalities in the hippocampus in dementia with Lewy bodies
    Mary Johnson
    Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, United Kingdom
    Hippocampus 21:1126-36. 2011
    Dementia with Lewy bodies (DLB) is associated with alpha synuclein pathology and slowly progressive dementia. Progenitor abnormalities have previously been reported in the subventricular zone (SVZ) adjacent to the lateral ventricle...
  83. doi In vivo microglia activation in very early dementia with Lewy bodies, comparison with Parkinson's disease
    S Iannaccone
    Neurorehabilitation Unit, Department of Clinical Neurosciences, San Raffaele Scientific Institute and Vita Salute University, Milan, Italy
    Parkinsonism Relat Disord 19:47-52. 2013
    ..We in vivo evaluated microglia activation in early dementia with Lewy bodies, still not reported, and compared with early Parkinson's disease, to assess possible differential pathological ..
  84. pmc Alpha-synuclein immunopositive aggregates in the myenteric plexus of the aging Fischer 344 rat
    Robert J Phillips
    Purdue University, Department of Psychological Sciences, 703 Third Street, West Lafayette, IN 47907 2081, USA
    Exp Neurol 220:109-19. 2009
    ..Finally, this study establishes the utility of the aging Fischer 344 rat for the study of synucleopathies and tauopathies in the GI tract...
  85. ncbi PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain
    Leah R Anderson
    Center for Neurodegenerative Disease, Graduate Program in Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    J Neuropathol Exp Neurol 66:955-64. 2007
    ..Moreover, RNF11 is expressed by vulnerable neurons of the substantia nigra and sequestered into Lewy bodies in brains of patients with idiopathic PD...
  86. doi Autophagic adapter protein NBR1 is localized in Lewy bodies and glial cytoplasmic inclusions and is involved in aggregate formation in α-synucleinopathy
    Saori Odagiri
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 124:173-86. 2012
    ..Our immunohistochemical examination revealed that the vast majority of Lewy bodies (LBs) in Parkinson's disease and dementia with LBs (DLB) as well as of glial cytoplasmic inclusions in multiple ..
  87. pmc Risk factors for dementia with Lewy bodies: a case-control study
    Brendon P Boot
    Department of Neurology, Mayo Clinic College of Medicine, Rochester MN, Scottsdale, AZ, USA
    Neurology 81:833-40. 2013
    To determine the risk factors associated with dementia with Lewy bodies (DLB).
  88. ncbi Recent knowledge on molecular components of Lewy bodies discloses future therapeutic strategies in Parkinson's disease
    F Fornai
    Department of Human Morphology and Applied Biology, University of Pisa, Pisa, Italy
    Curr Drug Targets CNS Neurol Disord 2:149-52. 2003
    b>Lewy bodies (LB) were first described by Lewy in 1912 [1] as neuronal pale eosinophilic inclusions which became a pathological hallmark of Parkinson s disease (PD)...
  89. doi A stable proportion of Lewy body bearing neurons in the substantia nigra suggests a model in which the Lewy body causes neuronal death
    Sandrine Greffard
    Geriatrics Centre, Pavillon M Bottard, La Salpetriere Hospital, Pierre and Marie Curie Paris VI University, Paris, France
    Neurobiol Aging 31:99-103. 2010
    b>Lewy bodies in Parkinson disease could be innocent bystanders or active agents responsible for neuronal death...
  90. doi Immunohistochemical localization of X-linked inhibitor of apoptosis protein in brainstem-type and cortical Lewy bodies
    Yasuhiro Kawamoto
    Department of Neurology, Faculty of Medicine, Kyoto University, Sakyoku, Kyoto, Japan
    Neuroreport 23:162-7. 2012
    ..of XIAP and the relationship between XIAP and HtrA2/Omi in patients with Parkinson's disease or dementia with Lewy bodies. We conducted immunohistochemical studies on XIAP in formalin-fixed, paraffin-embedded sections from eight ..
  91. ncbi Verbal and visuospatial deficits in dementia with Lewy bodies
    David K Johnson
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 65:1232-8. 2005
    To investigate the cognitive decline in dementia with Lewy bodies (DLBs) and characterize the contribution of Lewy bodies (LBs) to cognitive impairment in the presence of concurrent Alzheimer disease (AD).
  92. ncbi Dementia with Lewy bodies: a review
    L Rampello
    Department of Neurosciences, University of Catania, Azienda Policlinico Neurologia, Via S Sofia, 78, Catania I 95125, Italy
    Arch Gerontol Geriatr 39:1-14. 2004
    The dementia with Lewy bodies (DLB) is the second major type of senile, degenerative dementia, after the Alzheimer disease (AD)...
  93. ncbi Early and widespread cholinergic losses differentiate dementia with Lewy bodies from Alzheimer disease
    Pietro Tiraboschi
    Neurologia, Ospedale San Paolo, Milano, Italy
    Arch Gen Psychiatry 59:946-51. 2002
    Reductions in cholinergic function occur in Alzheimer disease (AD) and dementia with Lewy bodies and correlate with cognitive decline. However, whether such alterations appear in early-stage disease is unclear.
  94. ncbi Degeneration process of Lewy bodies in the brains of patients with dementia with Lewy bodies using alpha-synuclein-immunohistochemistry
    E Iseki
    Department of Psychiatry, Yokohama City University School of Medicine, 3 9 Fukuura, Kanazawa Ku, 236 0004, Yokohama, Japan
    Neurosci Lett 286:69-73. 2000
    We investigated the degeneration process of Lewy bodies (LB) in the brains of dementia with Lewy bodies, using alpha-synuclein-immunohistochemistry...
  95. pmc Validation of the neuropathologic criteria of the third consortium for dementia with Lewy bodies for prospectively diagnosed cases
    Hiroshige Fujishiro
    Department of Pathology and Neuroscience, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    J Neuropathol Exp Neurol 67:649-56. 2008
    There is limited information on the validity of the pathologic criteria of the Third Consortium on Dementia with Lewy bodies (CDLB), and none are based on prospectively diagnosed cases...
  96. ncbi Clusterin/apolipoprotein J is associated with cortical Lewy bodies: immunohistochemical study in cases with alpha-synucleinopathies
    Kensuke Sasaki
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Acta Neuropathol 104:225-30. 2002
    ..J protein expression in cases with "alpha-synucleinopathies", such as Parkinson's disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA), was investigated using an immunohistochemical method for the labeling ..
  97. ncbi Striatal dopaminergic markers in dementia with Lewy bodies, Alzheimer's and Parkinson's diseases: rostrocaudal distribution
    M A Piggott
    MRC Neurochemical Pathology Unit, Department of Neuropathology, Old Age Psychiatry, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Brain 122:1449-68. 1999
    Dementia with Lewy bodies (DLB) is a neuropsychiatric disease associated with extrapyramidal features which differ from those of Parkinson's disease, including reduced effectiveness of L-dopa and severe sensitivity reactions to ..
  98. ncbi Non-uniformity in the regional pattern of Lewy pathology in brains of dementia with Lewy bodies
    Ryoko Yamamoto
    Department of Psychiatry, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Koto ku, Tokyo, Japan
    Neuropathology 25:188-94. 2005
    We examined the regional pattern of Lewy pathology in brains of dementia with Lewy bodies (DLB) to clarify whether Lewy pathology uniformly progresses or not...
  99. ncbi Essential tremor associated with focal nonnigral Lewy bodies: a clinicopathologic study
    Elan D Louis
    Gertrude H Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Arch Neurol 62:1004-7. 2005
    ..Essential tremor is one of the most common neurological diseases. Its links with Parkinson disease (PD) are often debated. There have been few published postmortem studies...
  100. ncbi In dementia with Lewy bodies, Braak stage determines phenotype, not Lewy body distribution
    D Weisman
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neurology 69:356-9. 2007
    We used an autopsy series to determine whether the newest dementia with Lewy bodies (DLB) consensus pathologic classification correlates with premortem diagnosis of DLB...
  101. ncbi Is dementia with Lewy bodies the second most common cause of dementia?
    Judith L Heidebrink
    Department of Neurology, University of Michigan, and Veterans Affairs Medical Center, Ann Arbor, Michigan, USA
    J Geriatr Psychiatry Neurol 15:182-7. 2002
    b>Lewy bodies were originally described in isolated brainstem nuclei in persons with Parkinson's disease. They have since been recognized as a widespread and common neuropathologic finding in individuals with dementia...

Research Grants81

  1. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2011
    ..The cytoplasmic protein aggregates known as Lewy bodies, described nearly 100 years ago in the regions of the brain affected by PD, such as the substantia nigra, locus ..
  2. Katherine P Rankin; Fiscal Year: 2016
    ....
  3. Exploring the Role of the Brain Epigenome: Cognitive Decline and Life Experiences
    David Alan Bennett; Fiscal Year: 2013
    ..abstract_text> ..
  4. Indicators of early neurodegeneration: gene-toxin interactions at the syanpse
    Felix E Schweizer; Fiscal Year: 2010
    ..In PD, the accumulation of protein aggregates in Lewy bodies points towards a deficit in protein processing and degradation...
  5. Alpha-Synuclein-Metal Complexes and Oxidative Stress in Parkinson's Disease
    Feimeng Zhou; Fiscal Year: 2012
    ..The major inclusion in degenerating dopaminergic cells (Lewy bodies) contains aggregates of the a-synuclein (a-syn) protein...
  6. R Lee Mosley; Fiscal Year: 2014
    ..In PD, nitrated a-synuclein (N-a-syn) is found aggregated within the cytoplasm and Lewy bodies of dopaminergic neurons within the substantia nigra and is released to the extraneuronal environment by dying ..
  7. Radiolabled MAO-B Substrates for Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..The overall goal of the project is to identify appropriate radiolabeled substrates that can be further evaluated and validated for applications in human PET imaging. ..
  8. High Sensitivity Mobile PET for Brain Imaging and Proton Therapy Monitoring
    Georges El Fakhri; Fiscal Year: 2010
    ....
  9. Cognitive Decline and Dementia: Life Experiences and the Brain Histone Epigenome
    David A Bennett; Fiscal Year: 2010
    ....
  10. Lei Yu; Fiscal Year: 2015
    ..This aim allows us to evaluate how actual brain pathology (e.g., microinfarcts, Lewy bodies, hippocampal sclerosis, and mixed pathologies) relates to antemortem states in the subset of participants ..
  11. Novel mechanism of neuroprotection against neurotoxins
    Jianhua Zhang; Fiscal Year: 2012
    ..b>Lewy bodies (LB) are the histopathological feature of PD and they consist of proteinaceous aggregates with 1-syn as the ..
  12. Proteinopathies of the Aging Central Nervous System
    Lennart Mucke; Fiscal Year: 2012
    ..Our studies will shed light on diverse neurodegenerative diseases and could provide the knowledge needed to better treat and prevent them. ..
  13. Pontine motor circuits
    Jun Lu; Fiscal Year: 2013
    ..g., multiple system atrophy, progressive supranuclear palsy and dementia with Lewy bodies) to varied degrees...
  14. Dissecting the Cytoplasmic Interactome of the Alpha7 nACHR Subtype
    WILLIAM J BRUCKER; Fiscal Year: 2013
    ..The interactome data gathered from the nicotine exposed mice will be compared to the unexposed mice to determine if any difference exists. ..
  15. Role of MyD88-5 in the pathogenesis of Parkinson's disease
    Bobby Thomas; Fiscal Year: 2012
    ..We have cloned a neuron-specific mitochondrial protein, called MyD88-5, which is enriched in Lewy bodies from brains of postmortem PD patients and in pathologically affected regions of the CNS in a mouse model of 1-..
  16. Jianhua Zhang; Fiscal Year: 2014
    ..Our work will determine the function of the autophagy-lysosomal pathway in reducing a-syn level and toxicity, a strategy relevant to improving treatment of PD and other a-synucleinopathies. ..
  17. Xuemei Huang; Fiscal Year: 2016
    ..by dopamine neuronal loss in the substantia nigra (SN) of the basal ganglia (BG) and the presence of Lewy bodies. The lack of in vivo biomarker(s) reflecting PD-related cell loss and associated pathoetiological/physiological ..
  18. Role of oligomeric alpha-synuclein in synucleinopathies
    Pamela J McLean; Fiscal Year: 2013
    ..is a pathological hallmark of neurodegenerative disorders such as Parkinson's disease (PD), dementia with Lewy bodies (DLB), Alzheimer's disease, Huntington's disease and prion protein disorders...
  19. DAVID HASTINGS CRIBBS; Fiscal Year: 2016
    ..Finally, we will compare the best multi-epitope [unreadable]-syn DNA vaccine against our best multi-epitope A[unreadable] DNA vaccine in the mixed pathology DLB-AD Tg mice (40). ..
  20. NEUROPATHOLOGY OF CHRONIC MANGANESE EXPOSURE
    Brad A Racette; Fiscal Year: 2010
    ..Distribution of Lewy bodies, Lewy neurites and alpha-synuclein aggregates, if any, will also be evaluated after tissues are stained with an ..
  21. Identification of a Novel Gene for Parkinson Disease
    Han Xiang Deng; Fiscal Year: 2012
    ..Pathological analysis of the two autopsy samples revealed Parkinson pathology, including typical Lewy bodies. But the unaffected member did not show PD pathology...
  22. Cytoprotective mechanism against misfolded SOD1-induced toxicity
    CHERYL HO YUNG; Fiscal Year: 2013
    ..When these systems are impaired or overwhelmed, misfolded proteins accumulate to form aggregates, such as Lewy bodies in Parkinson's disease and neurofibrillary tangles and amyloid plaques in Alzheimer's disease...
  23. Metabolite Initiated Protein Misfolding and Amyloidosis
    Jeffery W Kelly; Fiscal Year: 2013
    ..abstract_text> ..
  24. Role of UCH-L1 Oxidative Modification in Parkinson's Disease Pathogenesis
    JEANNE ELIZABETH MCKEON; Fiscal Year: 2012
    ....
  25. Post-translational Modifications of Proteins in Parkinson?s disease
    Jing Zhang; Fiscal Year: 2012
    ..have repeatedly demonstrated that dementia in PD patients (PD-D) is associated with either formation of Lewy bodies (LBs) or Alzheimer's changes (presence of neurofibrillary tangles (NfTs) and senile plaques (SPs)) in the ..
  26. Dopamine, mutant synuclein, oxidative stress and inflammation
    Howard J Federoff; Fiscal Year: 2010
    ..with the hallmark pathological features of activated microglia and proteinaceous cytoplasmic inclusions called Lewy bodies in the remaining neurons...
  27. A Novel Ubiquitin-Dependent Pathogenic Pathway in Spongiform Neurodegeneration
    Lih Shen Chin; Fiscal Year: 2013
    ..The results of the proposed studies will provide fundamental information needed for the development of effective therapeutics to combat age-related neurodegenerative diseases. ..
  28. Pleiotrophin for Neurorestoration in Parkinson's Disease
    SARA ELIZABETH GOMBASH LAMPE; Fiscal Year: 2013
    ..These results may ultimately determine if PTN gene transfer can be used as a therapeutic option for PD and other nervous system disorders. ..
  29. NIKOLAUS RENZ MCFARLAND; Fiscal Year: 2014
    ..Alpha- synuclein ([unreadable]Syn) is a principal component of Lewy bodies found pathologically in Parkinson disease (PD) and related disorders, such as dementia with Lewy bodies (DLB) ..
  30. Influence of Dietary Fish and mercury Exposure on Brain health and Dementia
    Martha Clare Morris; Fiscal Year: 2013
    ..selenium (Se) are related to brain neuropathology (A[unreadable], neurofibrillary tangles, cerebral infarcts, Lewy bodies), inflammation (microglia), and neural reserve (synaptic protein density), to clinical outcomes (cognitive ..
  31. Cellular Mechanisms of Neuropathology in Parkinson's Disease
    John J Shacka; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The accumulation of alpha-synuclein (ASYN)-containing Lewy bodies and associated degeneration of dopamine (DA) neurons are major pathological hallmarks of Parkinson's disease (PD)...
  32. David Alan Bennett; Fiscal Year: 2016
    ..We found that AD pathology often does not cause dementia in the absence of cerebral infarcts and Lewy bodies. Further, we found that loneliness, psychological distress, and cognitive activity were all related to incident ..
  33. Epidemiology of Brain Aging in the Very Old
    LON RAY WHITE; Fiscal Year: 2011
    ..a population-based longitudinal study of Alzheimer's disease (AD), vascular dementia (VaD), dementia with Lewy bodies (DLB), mild cognitive impairment (MCI), and Parkinson's disease (PD)...
  34. Beclin 1 Neurodegeneration and Alzheimer's Disease
    Tony Wyss-Coray; Fiscal Year: 2013
    ..If we inhibit this protein degradation process in AD mice they develop more disease. We propose to study this process to try to reduce disease in mice and possibly in AD. ..
  35. Gene Interactions in a Model of Alzheimer's Disease
    Frank M LaFerla; Fiscal Year: 2012
    ..Up to 50% of AD cases exhibit a- synuclein immunoreactive Lewy Bodies in addition to plaques and tangles (Raghavan et al., 1993;Hamilton, 2000)...
  36. Alpha-synuclein RNAi in a model of sporadic Parkinson's disease
    EDWARD ALAN BURTON; Fiscal Year: 2012
    ..substantia nigra, including formation of prominent [unreadable]-synuclein immunoreactive inclusions resembling Lewy bodies and degeneration of dopaminergic neurons...
  37. In vivo modeling of TDP-43 toxicity
    JADA M LEWIS; Fiscal Year: 2011
    ..observed in a group of secondary TDP-proteinopathies including Alzheimer's Disease (AD), Dementia with Lewy Bodies (DLB), Pick Disease (PiD), and hippocampal sclerosis...
  38. Inflammation and the Ubiquitin/Proteasome Pathway in Neurodegeneration.
    MARIA EMILIA FIGUEIREDO PEREIRA; Fiscal Year: 2010
    ..SPECIFIC AIM #1: Examine how PGJ2 causes ubiquitin/1-synuclein aggregation &its role in cell death Lewy bodies (LB) are a pathologic hallmark of PD. The major LB components are ubiquitinated proteins and 1-synuclein...
  39. Vesicle trafficking defects &mitochondrial dysfunction related to a-syn toxicity
    PAVAN KUMAR AULUCK; Fiscal Year: 2013
    ..The synucleinopathies, Parkinson disease and dementia with Lewy bodies, are second only to Alzheimer disease in frequency among the elderly...
  40. Parkinson's Disease and Mechanisms of Fast Axonal Transport
    Ramona Pufan; Fiscal Year: 2009
    ..Starting in middle age, patients begin neuronal degeneration that continues until death. My goal is to test possible mechanisms underlying neuronal death in PD, and to find potential therapeutic targets for this disease. ..
  41. A Model of Proteasome Dysfunction in the Nervous System of Drosophila
    Thomas Schmidt-Glenewinkel; Fiscal Year: 2012
    ..applicant): Most neurodegenerative disorders are associated with aggregates of ubiquitinated proteins, such as Lewy bodies in Parkinson's disease and neurofibrillary tangles in Alzheimer's disease...
  42. Epidemiology of Aging and Dementia-Autopsy Research
    LON RAY WHITE; Fiscal Year: 2010
    ..Cortical Lewy bodies account for 10%, hippocampal sclerosis for 4%, and mixed (codominant) lesions for 18% of the dementia cases...
  43. Vladislav A Petyuk; Fiscal Year: 2015
    ..of Parkinson's disease is associated with the presence and distribution of proteinaceous aggregates called Lewy bodies (LBs). Sadly, the presence of LBs can be determined only post-mortem by a pathologist...
  44. Michigan Alzheimer's Disease Research Center
    Sid Gilman; Fiscal Year: 2010
    ..with [11C]DTBZ in predicting the evolution of early dementia into clinically distinguished AD, dementia with Lewy bodies, and frontotemporal dementia...
  45. a-Synuclein and Dopamine: Implications of Parkinsonism
    Ruth G Perez; Fiscal Year: 2010
    ..The small protein, D-synuclein (a-Syn), is implicated in PD by its abundance in Lewy bodies and by geo 14-3-3 chaperones to regulate the activity of key enzymes...
  46. Pathogenesis Of Essential Tremor: Cerebellar Metabolism
    Elan D Louis; Fiscal Year: 2012
    ..7% have brainstem Lewy bodies. Hence, at this point, we have described several basic changes in the ET brain...
  47. Eugene V Mosharov; Fiscal Year: 2015
    ..Parkinson's disease (PD) is characterized by aggregation of alpha-synuclein (a-synuclein) into "Lewy bodies" and "Lewy neurites", and a progressive loss of specific neuronal populations...
  48. RISK FACTORS, PATHOLOGY, AND CLINICAL EXPRESSIONS OF AD
    David Alan Bennett; Fiscal Year: 2013
    ..We quantified AD pathology, cerebral infarctions, and Lewy bodies in brain tissue from 300 persons and found that one or more of these pathologies is present in virtually ..
  49. Identifying the clinicopathologic basis of dementia-related psychosis
    Katherine P Rankin; Fiscal Year: 2013
    ..of aging: Alzheimer's disease (AD), behavioral variant frontotemporal dementia (bvFTD) and dementia with Lewy bodies (DLB)...
  50. Cathepsin D as a therapeutic tool for Parkinson's disease
    Daniel Sevlever; Fiscal Year: 2012
    ..sporadic and familial PD cases are also characterized by the presence of brain inclusions known as Lewy bodies and Lewy neurites that are primarily composed of fibrillar 1-synuclein (1- syn)...
  51. Asgar Zaheer; Fiscal Year: 2015
    ..PD is characterized by the presence of degenerating dopaminergic neurons, Lewy bodies and activated glia in brain...
  52. Jing Qiong Kang; Fiscal Year: 2016
    ..the aggregates were similar to those identified in inclusions found in neurodegenerative diseases, such as the Lewy bodies characteristic of Parkinson's disease...
  53. Eunsung Junn; Fiscal Year: 2015
    ..Postmortem investigations have demonstrated fibrillar a-Syn aggregates in Lewy bodies and Lewy neurites in affected brain regions in these disorders...
  54. Brian C Kraemer; Fiscal Year: 2016
    ..disorders including FTLD-U, ALS, Alzheimer's disease (AD), Parkinson's disease, dementia with Lewy bodies, and Guam amyotrophic lateral sclerosis/Parkinson's dementia...
  55. Jonathan N Sachs; Fiscal Year: 2016
    ..Although the formation of Lewy bodies, mediated by the aggregation of [unreadable]S into insoluble fibrils, is commonly associated with PD, high ..
  56. Development of a Plasma Biomarker of Alzheimer's Disease
    MARK ANTHONY LOVELL; Fiscal Year: 2012
    ..This protein-protein complex is a sensitive and specific biomarker of AD including early stages of AD when therapeutic interventions are most likely to have beneficial effects. ..
  57. Wanda F Reynolds; Fiscal Year: 2015
    ..neurons in the substantia nigra pars compacta (SNpc) with accumulation of a-synuclein (a-syn) in aggregates and Lewy bodies. Oxidative stress is implicated as a causative factor...
  58. ERNEST JAMES PETERSSON; Fiscal Year: 2015
    ..Using thioamide fluorescence quenching, we will generate structural models of the aggregation intermediates and validate these models with fluorescence measurements made in cultured cells. ..
  59. Robert H Edwards; Fiscal Year: 2014
    ..in [unreadable]-synuclein can cause autosomal dominant PD, and [unreadable]-synuclein accumulates in the Lewy bodies and dystrophic neurites of sporadic PD, suggesting a role for the protein in most forms of the disorder...
  60. ORNIT FALEK; Fiscal Year: 2016
    ..diseases, known as human 'synucleinopathies', is the presence of intracellular protein aggregates, Lewy bodies (LB), upon postmortem brain examination. The alpha-synuclein protein is a major component of LB...
  61. GENETICS AND MOLECULAR BIOLOGY OF PARKINSONISM
    Dennis Dickson; Fiscal Year: 2009
    ..Section as well as epidemiologic and longitudinal studies of Parkinson's disease (PD), dementia with Lewy bodies and aging that provide clinical material for research projects...
  62. Biophysical analysis of LRRK2
    DAVID MICHAEL JAMESON; Fiscal Year: 2012
    ..interactions between LRRK2 and a-synuclein, the major component of the pathognomonic neuronal inclusions of PD (Lewy bodies)...
  63. First Person Vision for Objective Evaluation of Caregiving Quality
    JUDITH T MATTHEWS; Fiscal Year: 2013
    ..FPV data gathered in these investigations will be used to develop algorithms for an innovative, automated tool for objective assessment and timely, tailored intervention aimed at improving caregiving quality and safety. ..
  64. Glucocerebrosidase mutations in a mouse synucleinopathy model
    Robert L Nussbaum; Fiscal Year: 2010
    ..The cytoplasmic protein aggregates known as Lewy bodies, described nearly 100 years ago in the regions of the brain affected by PD, such as the substantia nigra, locus ..
  65. FREE RADICALS, PROTEIN AGGREGATES & PARKINSON'S DISEASE
    GARY PIELAK; Fiscal Year: 2001
    ..Exposure to the herbicide paraquat is associated with an increased risk of Parkinson's Disease. Lewy bodies, the pathological marker of the disease, are abnormal protein aggregates found in cells of the substantia nigra...
  66. Robert A Rissman; Fiscal Year: 2015
    ..abstract_text> ..
  67. 18F-AV-133, A Novel Radiopharmaceutical for Differential Diagnosis of Dementia
    Franz Hefti; Fiscal Year: 2009
    ..by applicant): Dementia, with its most prevalent subforms Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and vascular dementia, is a very substantial medical and societal problem...
  68. INTERACTIONS BETWEEN ALPHA-SYNUCLEIN/METALS/PESTICIDES
    Donato Di Monte; Fiscal Year: 2003
    ..metals and pesticides) induces the aggregation of alpha-synuclein and formation of Lewy body-like inclusions (Lewy bodies are one of the pathologic hallmark of Parkinson's Disease)...
  69. Nocardia: A Novel Environmental Agent For Parkinsonism?
    Peter LeWitt; Fiscal Year: 2003
    ..These outcomes will be significant because they should add to our understanding of the neurodegenerative process in PD, and could lead to improved means of diagnosis and treatment for individuals with this disorder. ..
  70. NEUROPSYCHOLOGY OF DEMENTIA WITH LEWY BODIES
    TANIS FERMAN; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): The existing diagnostic criteria for Dementia with Lewy bodies (DLB) has been criticized for being inadequate at differentiating DLB from Alzheimer's disease (AD)...
  71. High Throughout Assay to Probe UCH-L1 Ligase Inhibitors
    Peter Lansbury; Fiscal Year: 2005
    Parkinson's disease (PD) is characterized by the presence of Lewy bodies (the cytoplasmic neuronal inclusions) and the significant loss of dopaminergic neurons in the substantia nigra, a-synuclein was identified as one major fibril ..
  72. Structure and Mechanism of the Parkin Ubiquitin Ligase
    Brenda Schulman; Fiscal Year: 2003
    ..has long been linked to Parkinson's Disease, because the aggregated inclusions founding patients, called Lewy Bodies, contain ubiquitin...
  73. Dopamine and choline transporter imaging in DLB & AD
    ERIC PETRIE; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) are the two most common causes of dementia...
  74. Visual Cognition in Dementia with Lewy Bodies
    Joanne M Hamilton; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Dementia with Lewy Bodies (DLB) is the second most common cause of neurodegenerative dementia in the elderly, accounting for between 10% and 30% of autopsied cases...
  75. CLINICAL RESEARCH CENTER STUDY OF SENILE DEMENTIA
    Jerome Yesavage; Fiscal Year: 1992
    ..The present application is a competitive renewal for the Center which has received modest funding since October 1984...