interneurons

Summary

Summary: Most generally any neurons which are not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.

Top Publications

  1. pmc Activation of specific interneurons improves V1 feature selectivity and visual perception
    Seung Hee Lee
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Nature 488:379-83. 2012
  2. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
  3. pmc Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
    Vikaas S Sohal
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 459:698-702. 2009
  4. pmc Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli
    Bassam V Atallah
    Computational Neurosciences Graduate Program, University of California San Diego, La Jolla, California 92093 0634, USA
    Neuron 73:159-70. 2012
  5. pmc A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
    Hiroki Taniguchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 71:995-1013. 2011
  6. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
  7. pmc Regulation of cortical microcircuits by unitary GABA-mediated volume transmission
    Szabolcs Oláh
    Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Nature 461:1278-81. 2009
  8. pmc Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons
    Inseon Song
    RIKEN Brain Science Institute BSI, Wako, Saitama 351 0198, Japan
    Nat Commun 2:376. 2011
  9. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
  10. pmc The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
    SooHyun Lee
    Smilow Neuroscience Program, Department of Physiology and Neuroscience, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:16796-808. 2010

Detail Information

Publications328 found, 100 shown here

  1. pmc Activation of specific interneurons improves V1 feature selectivity and visual perception
    Seung Hee Lee
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720, USA
    Nature 488:379-83. 2012
    Inhibitory interneurons are essential components of the neural circuits underlying various brain functions...
  2. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
    ..The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior...
  3. pmc Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
    Vikaas S Sohal
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 459:698-702. 2009
    Synchronized oscillations and inhibitory interneurons have important and interconnected roles within cortical microcircuits...
  4. pmc Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli
    Bassam V Atallah
    Computational Neurosciences Graduate Program, University of California San Diego, La Jolla, California 92093 0634, USA
    Neuron 73:159-70. 2012
    ..These results indicate that PV cells are ideally suited to modulate cortical gain and establish a causal relationship between a select neuron type and specific computations performed by the cortex during sensory processing...
  5. pmc A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
    Hiroki Taniguchi
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 71:995-1013. 2011
    ..to understanding neural circuits in the cerebral cortex is that of unraveling the diversity of GABAergic interneurons. This diversity poses general questions for neural circuit analysis: how are these interneuron cell types ..
  6. pmc Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex
    Giorgio A Ascoli
    Molecular Neuroscience Department and Center for Neural Informatics, Structures, and Plasticity, Krasnow Institute for Advanced Study, George Mason University, MS2A1, 4400 University Drive, Fairfax, Virginia 22030, USA
    Nat Rev Neurosci 9:557-68. 2008
    ..The problems inherent in this are particularly acute when studying cortical interneurons. To tackle this, we convened a representative group of researchers to agree on a set of terms to describe the ..
  7. pmc Regulation of cortical microcircuits by unitary GABA-mediated volume transmission
    Szabolcs Oláh
    Research Group for Cortical Microcircuits of the Hungarian Academy of Sciences, Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Nature 461:1278-81. 2009
    GABA (gamma-aminobutyric acid) is predominantly released by local interneurons in the cerebral cortex to particular subcellular domains of the target cells...
  8. pmc Tonic excitation or inhibition is set by GABA(A) conductance in hippocampal interneurons
    Inseon Song
    RIKEN Brain Science Institute BSI, Wako, Saitama 351 0198, Japan
    Nat Commun 2:376. 2011
    ..Here we show that ambient GABA, the main inhibitory neurotransmitter in the brain, can excite adult hippocampal interneurons. In these cells, the GABA(A) current reversal potential is depolarizing, making baseline tonic GABA(A) ..
  9. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit...
  10. pmc The largest group of superficial neocortical GABAergic interneurons expresses ionotropic serotonin receptors
    SooHyun Lee
    Smilow Neuroscience Program, Department of Physiology and Neuroscience, Smilow Research Center, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:16796-808. 2010
    A highly diverse population of neocortical GABAergic inhibitory interneurons has been implicated in multiple functions in information processing within cortical circuits...
  11. pmc Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach
    Toshiharu Yasaka
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Pain 151:475-88. 2010
    Lamina II contains a large number of interneurons involved in modulation and transmission of somatosensory (including nociceptive) information...
  12. ncbi The shaping of male courtship posture by lateralized gustatory inputs to male-specific interneurons
    Masayuki Koganezawa
    Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8578, Japan
    Curr Biol 20:1-8. 2010
    ..These observations prompted the postulation that the proper wing display by courting males of D. melanogaster does not require sensory inputs...
  13. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  14. pmc Cortical parvalbumin interneurons and cognitive dysfunction in schizophrenia
    David A Lewis
    Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Trends Neurosci 35:57-67. 2012
    ..This compensation is thought to rebalance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control...
  15. ncbi Mechanisms of gamma oscillations in the hippocampus of the behaving rat
    Jozsef Csicsvari
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA
    Neuron 37:311-22. 2003
    ..Both pyramidal cells and interneurons were phase-locked to gamma waves...
  16. pmc OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons
    Richardson N Leao
    Developmental Genetics, Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Nat Neurosci 15:1524-30. 2012
    The vast diversity of GABAergic interneurons is believed to endow hippocampal microcircuits with the required flexibility for memory encoding and retrieval...
  17. pmc Dense, unspecific connectivity of neocortical parvalbumin-positive interneurons: a canonical microcircuit for inhibition?
    Adam M Packer
    HHMI, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    J Neurosci 31:13260-71. 2011
    GABAergic interneurons play a major role in the function of the mammalian neocortex, but their circuit connectivity is still poorly understood...
  18. ncbi Striatal dopamine release is triggered by synchronized activity in cholinergic interneurons
    Sarah Threlfell
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford, UK
    Neuron 75:58-64. 2012
    ..We paired electrophysiological recordings of striatal channelrhodopsin2-expressing cholinergic interneurons with simultaneous detection of dopamine release at carbon-fiber microelectrodes in striatal slices...
  19. pmc The organization of two new cortical interneuronal circuits
    xiaolong Jiang
    Department of Pharmacology, School of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Nat Neurosci 16:210-8. 2013
    ..recordings, we found two previously unknown interneuronal circuits that link cortical layer 1-3 (L1-3) interneurons and L5 pyramidal neurons in the rat neocortex...
  20. pmc Local GABA circuit control of experience-dependent plasticity in developing visual cortex
    T K Hensch
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Science 282:1504-8. 1998
    ..Specific networks of inhibitory interneurons intrinsic to visual cortex may detect perturbations in sensory input to drive experience-dependent plasticity ..
  21. ncbi A disinhibitory microcircuit for associative fear learning in the auditory cortex
    Johannes J Letzkus
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH 4058 Basel, Switzerland
    Nature 480:331-5. 2011
    ..disinhibition in auditory cortex is driven by foot-shock-mediated cholinergic activation of layer 1 interneurons, in turn generating inhibition of layer 2/3 parvalbumin-positive interneurons...
  22. pmc Driving fast-spiking cells induces gamma rhythm and controls sensory responses
    Jessica A Cardin
    McGovern Institute for Brain Research and Department of Brain and Cognitive Sciences, MIT, Cambridge, Massachusetts 02139, USA
    Nature 459:663-7. 2009
    ..theory predicts that gamma oscillations are generated by synchronous activity of fast-spiking inhibitory interneurons, with the resulting rhythmic inhibition producing neural ensemble synchrony by generating a narrow window for ..
  23. pmc Classification of NPY-expressing neocortical interneurons
    Anastassios Karagiannis
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique CNRS, Ecole Superieure de Physique et de Chimie Industrielles, Universite Pierre et Marie Curie, Paris, France
    J Neurosci 29:3642-59. 2009
    ..that NPY neurons are nearly exclusively GABAergic and consistently disclosed three main types of NPY-expressing interneurons. (1) Neurogliaform-like neurons exhibiting a dense axonal arbor, were the most frequent and superficial, and ..
  24. pmc Circuits controlling vertebrate locomotion: moving in a new direction
    Martyn Goulding
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Neurosci 10:507-18. 2009
    ....
  25. pmc Defined types of cortical interneurone structure space and spike timing in the hippocampus
    Peter Somogyi
    MRC Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    J Physiol 562:9-26. 2005
    ....
  26. ncbi Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
    Marlene Bartos
    Physiologisches Institut der Universität Freiburg, Abteilung 1, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Nat Rev Neurosci 8:45-56. 2007
    ..Fast-spiking, parvalbumin-expressing, soma-inhibiting interneurons have a key role in the generation of these oscillations...
  27. pmc The cell-intrinsic requirement of Sox6 for cortical interneuron development
    Renata Batista-Brito
    Smilow Neuroscience Program and the Department of Cell Biology, Smilow Research Building, New York University School of Medicine, 522 First Avenue, New York, NY 10016, USA
    Neuron 63:466-81. 2009
    ..We identify Sox6 as a protein expressed continuously within MGE-derived cortical interneurons from postmitotic progenitor stages into adulthood...
  28. pmc Genetic fate mapping reveals that the caudal ganglionic eminence produces a large and diverse population of superficial cortical interneurons
    Goichi Miyoshi
    Smilow Neuroscience Program and the Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 30:1582-94. 2010
    ..with electrophysiological analysis, we have systematically characterized the populations of cortical GABAergic interneurons that originate from the caudal ganglionic eminence (CGE)...
  29. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ..of cortical intrinsic mechanisms, we developed a method to visualize perisomatic synapses from single basket interneurons in cortical organotypic cultures...
  30. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, CHU Pitie Salpetriere, Universite Paris VI, 75013 Paris, France
    Science 298:1418-21. 2002
    ..The network of neurons discharging during population events comprises both subicular interneurons and a subgroup of pyramidal cells...
  31. pmc SOX6 controls dorsal progenitor identity and interneuron diversity during neocortical development
    Eiman Azim
    Massachusetts General Hospital Harvard Medical School Center for Nervous System Repair, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 12:1238-47. 2009
    ..of dorsal (pallial) from ventral (subpallial) telencephalic progenitors and the differentiation of cortical interneurons, regulating forebrain progenitor and interneuron heterogeneity...
  32. pmc Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells
    Asif M Maroof
    Center for Stem Cell Biology, Sloan Kettering Institute for Cancer Research, 1275 York Ave, New York, NY 10065, USA
    Cell Stem Cell 12:559-72. 2013
    ..The human cortex is composed of two major neuronal populations: projection neurons and local interneurons. Cortical interneurons comprise a diverse class of cell types expressing the neurotransmitter GABA...
  33. pmc Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development
    Cory R Nicholas
    The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Stem Cell 12:573-86. 2013
    ..of hPSCs into medial ganglionic eminence (MGE)-like progenitors and their maturation into forebrain type interneurons. We find that early-stage progenitors progress via a radial glial-like stem cell enriched in the human fetal ..
  34. ncbi GABA uptake regulates cortical excitability via cell type-specific tonic inhibition
    Alexey Semyanov
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    Nat Neurosci 6:484-90. 2003
    ..We show that, in the presence of intact GABA uptake, guinea pig hippocampal interneurons, but not pyramidal cells, express a tonic GABA(A) receptor-mediated conductance...
  35. pmc Intrinsically determined cell death of developing cortical interneurons
    Derek G Southwell
    Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
    Nature 491:109-13. 2012
    Cortical inhibitory circuits are formed by γ-aminobutyric acid (GABA)-secreting interneurons, a cell population that originates far from the cerebral cortex in the embryonic ventral forebrain...
  36. ncbi Regulation of neuronal input transformations by tunable dendritic inhibition
    Matthew Lovett-Barron
    Department of Neuroscience, Columbia University, New York, New York, USA
    Nat Neurosci 15:423-30, S1-3. 2012
    ..Dendrite-targeting interneurons are themselves modulated by interneurons targeting pyramidal cell somata, providing a synaptic substrate for ..
  37. ncbi Origins of cortical interneuron subtypes
    Qing Xu
    Department of Psychiatry, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 24:2612-22. 2004
    ..functions are conducted by two general classes of neurons: glutamatergic projection neurons and GABAergic interneurons. Distinct interneuron subtypes serve distinct roles in modulating cortical activity and can be differentially ..
  38. pmc Fast synaptic inhibition in spinal sensory processing and pain control
    Hanns Ulrich Zeilhofer
    Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
    Physiol Rev 92:193-235. 2012
    ..Particular emphasis is placed on the role and mechanisms of spinal inhibitory malfunction in inflammatory and neuropathic chronic pain syndromes...
  39. pmc Selective activation of cholinergic interneurons enhances accumbal phasic dopamine release: setting the tone for reward processing
    Roger Cachope
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Cell Rep 2:33-41. 2012
    ..More importantly, we demonstrate that in vivo selective activation of cholinergic interneurons is sufficient to elicit dopamine release in the nucleus accumbens...
  40. ncbi Shunting inhibition improves robustness of gamma oscillations in hippocampal interneuron networks by homogenizing firing rates
    Imre Vida
    Anatomisches Institut, Universitat Freiburg, Albertstr 17, D 79104 Freiburg, Germany
    Neuron 49:107-17. 2006
    ..Here, we show that GABA(A) receptor-mediated inhibition in mature interneurons of the hippocampal dentate gyrus is shunting rather than hyperpolarizing...
  41. pmc Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes
    Juan E Belforte
    Unit on Genetics of Cognition and Behavior, Mood and Anxiety Disorders Program, Intramural Research Program, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 13:76-83. 2010
    ..NR1 subunit of the NMDA receptor (NMDAR) was selectively eliminated in 40-50% of cortical and hippocampal interneurons in early postnatal development...
  42. ncbi TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord
    Yong Ho Kim
    National Research Laboratory for Pain, Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 110 749, Republic of Korea
    Neuron 74:640-7. 2012
    ..a mechanism of disinhibition-based central sensitization resulting from long-term depression (LTD) of GABAergic interneurons as a consequence of TRPV1 activation in the spinal cord...
  43. pmc Cortical interneurons that specialize in disinhibitory control
    Hyun Jae Pi
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA
    Nature 503:521-4. 2013
    ..Although several interneuron populations are known to target other interneurons to varying degrees, little is known about interneurons specializing in disinhibition and their in vivo function...
  44. pmc Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation?
    Thomas S Kilduff
    Center for Neuroscience, Biosciences Division, SRI International, Menlo Park, CA 94025, USA
    Trends Neurosci 34:10-9. 2011
    ..neurons typically exhibit reduced discharge rates during slow wave sleep (SWS), a subpopulation of GABAergic interneurons, which express the enzyme neuronal nitric oxide synthase (nNOS), has recently been found to be activated during ..
  45. ncbi A wide diversity of cortical GABAergic interneurons derives from the embryonic preoptic area
    Diego Gelman
    Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, Sant Joan d Alacant 03550, Spain
    J Neurosci 31:16570-80. 2011
    GABA-containing (GABAergic) interneurons comprise a very heterogeneous group of cells that are crucial for cortical function...
  46. ncbi Membrane potential dynamics of GABAergic neurons in the barrel cortex of behaving mice
    Luc J Gentet
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Neuron 65:422-35. 2010
    ..In contrast, inhibitory neurons fire correlated action potentials at much higher frequencies driven by slower, smaller, and broadly synchronized depolarization...
  47. ncbi The gamma cycle
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Neurosci 30:309-16. 2007
    ..and modeling studies demonstrate that each gamma cycle is framed by synchronized spiking of inhibitory interneurons. Here, we review evidence suggesting that the resulting rhythmic network inhibition interacts with excitatory ..
  48. ncbi Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina
    Masahito Yamagata
    Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 451:465-9. 2008
    ..Processes of retinal interneurons (amacrine and bipolar cells) form synapses on dendrites of RGCs in the inner plexiform layer (IPL)...
  49. pmc Three groups of interneurons account for nearly 100% of neocortical GABAergic neurons
    Bernardo Rudy
    Smilow Neuroscience Program, Smilow Research Center, New York University School of Medicine, 550 First Avenue, New York, NY, 10016, USA
    Dev Neurobiol 71:45-61. 2011
    An understanding of the diversity of cortical GABAergic interneurons is critical to understand the function of the cerebral cortex...
  50. ncbi Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, SE 221 84 Lund, Sweden
    J Neurosci 23:9620-31. 2003
    ..of this receptive field plasticity, we present for the first time whole-cell patch-clamp recordings from these interneurons during natural and electrical activation of cutaneously driven synaptic input...
  51. ncbi Cortical GABA interneurons in neurovascular coupling: relays for subcortical vasoactive pathways
    Bruno Cauli
    Laboratoire de Neurobiologie et Diversité Cellulaire, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7637, Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris, 75005 Paris, France
    J Neurosci 24:8940-9. 2004
    The role of interneurons in neurovascular coupling was investigated by patch-clamp recordings in acute rat cortical slices, followed by single-cell reverse transcriptase-multiplex PCR (RT-mPCR) and confocal observation of biocytin-filled ..
  52. ncbi Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
    Sayaka Sugiyama
    Lab for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Cell 134:508-20. 2008
    ..Thus, the experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit...
  53. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
    ..evidence that the pruritic phenotype in Bhlhb5 mutants is due to selective loss of a subset of inhibitory interneurons in the dorsal horn...
  54. pmc Sonic hedgehog signaling confers ventral telencephalic progenitors with distinct cortical interneuron fates
    Qing Xu
    Weill Cornell Medical College, 1300 York Avenue New York, NY 10065, USA
    Neuron 65:328-40. 2010
    b>Interneurons in the cerebral cortex regulate cortical functions through the actions of distinct subgroups that express parvalbumin, somatostatin, or calretinin. The genesis of the first two subgroups requires the expression of NKX2...
  55. ncbi Mosaic organization of neural stem cells in the adult brain
    Florian T Merkle
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, San Francisco, CA 94143 0525, USA
    Science 317:381-4. 2007
    ..This suggests that rather than being plastic and homogeneous, neural stem cells are a restricted and diverse population of progenitors...
  56. ncbi Synaptic basis of cortical persistent activity: the importance of NMDA receptors to working memory
    X J Wang
    Volen Center for Complex Systems, Department of Physics, Brandeis University, Waltham, Massachusetts 02454 9110, USA
    J Neurosci 19:9587-603. 1999
    ..This result suggests a critical role of the NMDA receptor channels in normal working memory function of the prefrontal cortex...
  57. pmc Cholinergic interneurons control local circuit activity and cocaine conditioning
    Ilana B Witten
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 330:1677-81. 2010
    ..freely moving mammalian behavior, in vivo electrophysiology, and slice physiology to probe the cholinergic interneurons of the nucleus accumbens by direct excitation or inhibition...
  58. pmc Origin and function of olfactory bulb interneuron diversity
    Pierre Marie Lledo
    Laboratory of Perception and Memory, Pasteur Institute, CNRS URA 2182, Paris Cedex, France
    Trends Neurosci 31:392-400. 2008
    ..of new neurons that migrate to the olfactory bulb (OB), where they differentiate into multiple types of interneurons. It has been generally considered that individual adult SVZ stem cells are capable of generating different ..
  59. ncbi Loss of Nkx2.1 homeobox gene function results in a ventral to dorsal molecular respecification within the basal telencephalon: evidence for a transformation of the pallidum into the striatum
    L Sussel
    Center for Neurobiology and Psychiatry, Department of Psychiatry and University of California at San Francisco, CA 94143 0984, USA
    Development 126:3359-70. 1999
    ..We present evidence that these phenotypes result from a ventral-to-dorsal transformation of the pallidal primordium into a striatal-like anlage...
  60. pmc Neocortical somatostatin-expressing GABAergic interneurons disinhibit the thalamorecipient layer 4
    Han Xu
    Department of Physiology and Neuroscience, Smilow Neuroscience Program, NYU School of Medicine, New York, NY 10016, USA
    Neuron 77:155-67. 2013
    Subtypes of GABAergic interneurons (INs) are crucial for cortical function, yet their specific roles are largely unknown...
  61. pmc Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome
    Christine S Cheah
    Department of Pharmacology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 109:14646-51. 2012
    ..studies using a mouse model of DS revealed reduced sodium currents and impaired excitability in GABAergic interneurons in the hippocampus, leading to the hypothesis that impaired excitability of GABAergic inhibitory neurons is the ..
  62. pmc Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons
    Carsten K Pfeffer
    Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, USA
    Nat Neurosci 16:1068-76. 2013
    ..three large, molecularly distinct interneuron populations in mouse visual cortex: parvalbumin-expressing interneurons strongly inhibit one another but provide little inhibition to other populations...
  63. pmc Frequency-invariant temporal ordering of interneuronal discharges during hippocampal oscillations in awake mice
    Csaba Varga
    Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 109:E2726-34. 2012
    ..cells are known to play key roles in network oscillations, the in vivo firing patterns of distinct hippocampal interneurons in awake animals are not known...
  64. ncbi Multiple climbing fibers signal to molecular layer interneurons exclusively via glutamate spillover
    German Szapiro
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS, 46 rue d Ulm, 75005 Paris, France
    Nat Neurosci 10:735-42. 2007
    ..Here we describe a pure spillover connection between the climbing fiber and molecular layer interneurons in the rat cerebellar cortex...
  65. pmc Dlx5 and Dlx6 regulate the development of parvalbumin-expressing cortical interneurons
    Yanling Wang
    Department of Psychiatry, Nina Ireland Laboratory of Developmental Neurobiology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:5334-45. 2010
    Dlx5 and Dlx6 homeobox genes are expressed in developing and mature cortical interneurons. Simultaneous deletion of Dlx5 and 6 results in exencephaly of the anterior brain; despite this defect, prenatal basal ganglia differentiation ..
  66. pmc A quantitative study of neuronal nitric oxide synthase expression in laminae I-III of the rat spinal dorsal horn
    T C P Sardella
    Institute of Neuroscience and Psychology, West Medical Building, University Avenue, University of Glasgow, Glasgow, G12 8QQ, UK
    Neuroscience 192:708-20. 2011
    ..early study that used a histochemical method to identify these cells suggested that they were mainly inhibitory interneurons. We have carried out a quantitative analysis of nNOS-immunoreactivity in laminae I-III of the rat dorsal horn, ..
  67. pmc A cluster of cholinergic premotor interneurons modulates mouse locomotor activity
    Laskaro Zagoraiou
    Howard Hughes Medical Institute, Kavli Institute for Brain Science, Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Neuron 64:645-62. 2009
    Mammalian motor programs are controlled by networks of spinal interneurons that set the rhythm and intensity of motor neuron firing...
  68. ncbi Spontaneous activity signatures of morphologically identified interneurons in the vestibulocerebellum
    Tom J H Ruigrok
    Department of Neuroscience, Erasmus Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Neurosci 31:712-24. 2011
    Cerebellar cortical interneurons such as Golgi cells, basket cells, stellate cells, unipolar brush cells, and granule cells play an essential role in the operations of the cerebellum...
  69. pmc Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex
    Christian Wozny
    MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK
    Cereb Cortex 21:1818-26. 2011
    ..In contrast, NGFCs strongly inhibited L2/3 pyramidal neurons (n = 12 out 27 pairs tested). These data reveal a high specificity of excitatory and inhibitory connections in the superficial layers of the neocortex...
  70. pmc Immunochemical characterization of inhibitory mouse cortical neurons: three chemically distinct classes of inhibitory cells
    Xiangmin Xu
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 518:389-404. 2010
    ..SOM), calretinin (CR), and cholecystokinin (CCK) label four distinct chemical classes of GABAergic interneurons. However, in contrast to rat cortex, previous studies indicate that there is significant colocalization of SOM ..
  71. pmc Inhibitory interneuron deficit links altered network activity and cognitive dysfunction in Alzheimer model
    Laure Verret
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Cell 149:708-21. 2012
    ..We conclude that reduced Nav1.1 levels and PV cell dysfunction critically contribute to abnormalities in oscillatory rhythms, network synchrony, and memory in hAPP mice and possibly in AD...
  72. ncbi Short- and long-range attraction of cortical GABAergic interneurons by neuregulin-1
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 San Joan d Alacant, Spain
    Neuron 44:251-61. 2004
    Most cortical interneurons arise from the subcortical telencephalon, but the molecules that control their migration remain largely unidentified...
  73. ncbi Functional diversity and specificity of neostriatal interneurons
    James M Tepper
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Curr Opin Neurobiol 14:685-92. 2004
    ..Neostriatal interneurons are phenotypically diverse and have properties that enable them to specifically, but differentially, influence ..
  74. ncbi GABAergic interneurons in the mouse lateral amygdala: a classification study
    Ludmila Sosulina
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Munster, Germany
    J Neurophysiol 104:617-26. 2010
    Whole cell patch-clamp recordings were performed in GABAergic interneurons labeled by green fluorescent protein (GFP) in the lateral amygdala (LA) in vitro from glutamic acid decarboxylase 67 (GAD67)-GFP mice...
  75. pmc A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior
    M Carlen
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, MIT, Cambridge, MA 02139, USA
    Mol Psychiatry 17:537-48. 2012
    Synchronous recruitment of fast-spiking (FS) parvalbumin (PV) interneurons generates gamma oscillations, rhythms that emerge during performance of cognitive tasks...
  76. pmc Parvalbumin-positive CA1 interneurons are required for spatial working but not for reference memory
    Andrew J Murray
    Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK
    Nat Neurosci 14:297-9. 2011
    Parvalbumin-positive GABAergic interneurons in cortical circuits are hypothesized to control cognitive function...
  77. pmc Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex
    Erika E Fanselow
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1458 Thomas E Starzl Biomedical Science Tower, 200 Lothrop St, Pittsburgh, PA 15261, USA
    J Neurophysiol 100:2640-52. 2008
    ..This is due in part to a dearth of information about the behaviors of interneurons under conditions when the surrounding circuit is in an active state...
  78. pmc A role for hilar cells in pattern separation in the dentate gyrus: a computational approach
    Catherine E Myers
    Department of Psychology, Rutgers University Newark, Newark, New Jersey, USA
    Hippocampus 19:321-37. 2009
    ..The model includes two of the major subtypes of hilar cells: excitatory hilar mossy cells and inhibitory hilar interneurons that receive input from and project to the perforant path terminal zone (HIPP cells)...
  79. pmc Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome
    Yuko Kataoka
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Comp Neurol 518:277-91. 2010
    ..In this study the density of different types of interneurons and medium spiny neurons (MSNs) in the striatum was assessed in the postmortem brains of 5 TS subjects as ..
  80. ncbi NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory
    Tatiana Korotkova
    Department of Clinical Neurobiology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 68:557-69. 2010
    Activity of parvalbumin-positive hippocampal interneurons is critical for network synchronization but the receptors involved therein have remained largely unknown...
  81. pmc KCC2 expression promotes the termination of cortical interneuron migration in a voltage-sensitive calcium-dependent manner
    Dante Bortone
    Neurobiology Curriculum, Neuroscience Center, Department of Pharmacology, University of North Carolina, Chapel Hill, 115 Mason Farm Road, Chapel Hill, NC 27599 7250, USA
    Neuron 62:53-71. 2009
    ..Here, we demonstrate that, prior to synaptogenesis, migrating interneurons change their responsiveness to ambient GABA from a motogenic to a stop signal...
  82. ncbi Cell type-specific tuning of hippocampal interneuron firing during gamma oscillations in vivo
    John J Tukker
    Medical Research Council Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, United Kingdom
    J Neurosci 27:8184-9. 2007
    ..contribute to cognitive processing and are thought to be supported by perisomatic-innervating GABAergic interneurons. We performed extracellular recordings of identified interneurons in the hippocampal CA1 area of anesthetized ..
  83. pmc Characterization of Nkx6-2-derived neocortical interneuron lineages
    Vitor H Sousa
    Neuroscience Program, Smilow Research Center, New York University, New York, NY 10016, USA
    Cereb Cortex 19:i1-10. 2009
    ..mapping and in vivo loss-of-function to analyze the requirement of Nkx6-2 in determining the fate of cortical interneurons. We have found that interneuron subtypes are born with a characteristic temporal pattern...
  84. ncbi Microfluidics for in vivo imaging of neuronal and behavioral activity in Caenorhabditis elegans
    Nikos Chronis
    Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    Nat Methods 4:727-31. 2007
    ..elegans. We used the behavior chip to correlate the activity of AVA command interneurons with the worm locomotion pattern...
  85. ncbi Female contact activates male-specific interneurons that trigger stereotypic courtship behavior in Drosophila
    Soh Kohatsu
    Division of Neurogenetics, Tohoku University Graduate School of Life Sciences, Sendai 980 8577, Japan
    Neuron 69:498-508. 2011
    ..the initiation of courtship behavior is significantly correlated with the activation of the transmidline P1 interneurons, the descending P2b interneurons, or both, indicating that these interneurons trigger courtship...
  86. ncbi GABAergic interneurons: implications for understanding schizophrenia and bipolar disorder
    F M Benes
    Laboratory for Structural Neuroscience, McLean Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 25:1-27. 2001
    ..in rodent, primate and human brain and the characterization of changes in specific phenotypic subclasses of interneurons in schizophrenia and bipolar disorder will undoubtedly provide important new insights into how the integration ..
  87. ncbi Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, The Biomedical Center F10, Tornavagen 10, SE 221 84, Sweden
    Neuron 34:797-806. 2002
    ..relationships between parallel fiber (PF) and climbing fiber (CF) receptive fields in Purkinje cells and interneurons suggest that normal PF receptive fields are established by CF-specific plasticity...
  88. pmc Spinal cholinergic interneurons regulate the excitability of motoneurons during locomotion
    Gareth B Miles
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 104:2448-53. 2007
    ..Anatomical data indicate that C boutons originate from a discrete group of interneurons lateral to the central canal, the medial partition neurons...
  89. ncbi Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons
    Zhongfeng Wang
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Neuron 50:443-52. 2006
    ..the need to lower M(1) muscarinic receptor activity-a goal accomplished by D(2) receptors on cholinergic interneurons. In addition to reconciling discordant tracts of the striatal literature, these findings point to cholinergic ..
  90. pmc CXCR4 and CXCR7 have distinct functions in regulating interneuron migration
    Yanling Wang
    Department of Psychiatry, University of California, San Francisco, CA 94158, USA
    Neuron 69:61-76. 2011
    ..Migrating cortical interneurons coexpressed Cxcr4 and Cxcr7, and Cxcr7(-/-) and Cxcr4(-/-) mutants had similar defects in interneuron ..
  91. pmc A loss of parvalbumin-containing interneurons is associated with diminished oscillatory activity in an animal model of schizophrenia
    Daniel J Lodge
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:2344-54. 2009
    ..in a verified animal model of schizophrenia, that a reduced expression of parvalbumin (PV)-containing interneurons is correlated with a reduction in coordinated neuronal activity during task performance in freely moving rats...
  92. ncbi The developmental integration of cortical interneurons into a functional network
    Renata Batista-Brito
    Smilow Neuroscience Program, New York University Medical Center, New York, USA
    Curr Top Dev Biol 87:81-118. 2009
    ..we begin by considering the mature properties that differentiate between the different populations of cortical interneurons. This requires us to address the difficulties involved in determining which characteristics allow particular ..
  93. pmc Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
    Lindsey L Glickfeld
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 12:21-3. 2009
    Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABA(A) receptors has been shown to depolarize specific neuronal compartments, resulting in excitation...
  94. ncbi Neurogliaform neurons form a novel inhibitory network in the hippocampal CA1 area
    Christopher J Price
    Anatomical Neuropharmacology Unit, Medical Research Council, Oxford OX1 3TH, United Kingdom
    J Neurosci 25:6775-86. 2005
    We studied neurogliaform neurons in the stratum lacunosum moleculare of the CA1 hippocampal area. These interneurons have short stellate dendrites and an extensive axonal arbor mainly located in the stratum lacunosum moleculare...
  95. ncbi Identified sources and targets of slow inhibition in the neocortex
    Gabor Tamas
    Department of Comparative Physiology, University of Szeged, Közép fasor 52, Szeged H 6726, Hungary
    Science 299:1902-5. 2003
    ..We identified a class of GABAergic interneurons, the neurogliaform cells, that, in contrast to other GABA-releasing cells, elicited combined GABA(A) and GABA(B)..
  96. pmc Selective expression of ErbB4 in interneurons, but not pyramidal cells, of the rodent hippocampus
    Detlef Vullhorst
    Section on Molecular Neurobiology, Eunice Shriver Kennedy National Institute of Child Health and Human Development, National Institute on Deafness and Other Communication Disorders, Bethesda, Maryland 20892 3714, USA
    J Neurosci 29:12255-64. 2009
    ..We detected ErbB4 immunoreactivity in GABAergic interneurons but not in pyramidal neurons, a finding that was further corroborated by the lack of ErbB4 mRNA in ..
  97. pmc Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
    Yaisa Andrews-Zwilling
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:13707-17. 2010
    ..We found that female apoE4 knock-in (KI) mice had an age-dependent decrease in hilar GABAergic interneurons that correlated with the extent of learning and memory deficits, as determined in the Morris water maze, in ..
  98. pmc Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex
    Caroline A Runyan
    Department of Brain and Cognitive Sciences and Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 67:847-57. 2010
    Inhibitory interneurons in the cerebral cortex include a vast array of subtypes, varying in their molecular signatures, electrophysiological properties, and connectivity patterns...
  99. ncbi Dendritic encoding of sensory stimuli controlled by deep cortical interneurons
    Masanori Murayama
    Physiologisches Institut, Universitat Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Nature 457:1137-41. 2009
    ..single apical tuft dendrites in vitro showed that activity in L5 pyramidal neurons disynaptically coupled via interneurons directly blocks the initiation of dendritic calcium spikes in neighbouring pyramidal neurons...
  100. ncbi Specific GABAA circuits for visual cortical plasticity
    Michela Fagiolini
    Laboratory for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama, 351 0198 Japan
    Science 303:1681-3. 2004
    ..This dissociation carries implications for models of brain development and the safe design of benzodiazepines for use in infants...
  101. ncbi Dissecting a circuit for olfactory behaviour in Caenorhabditis elegans
    Sreekanth H Chalasani
    Howard Hughes Medical Institute, Laboratory of Neural Circuits and Behaviour, The Rockefeller University, New York, New York 10065, USA
    Nature 450:63-70. 2007
    ..Here we characterize information processing by Caenorhabditis elegans olfactory neurons (AWC) and interneurons (AIB and AIY) that control food- and odour-evoked behaviours...

Research Grants71

  1. Systemic Inflammation and Central Nervous System Dysfunction
    Laura L Dugan; Fiscal Year: 2013
    ..Inflammatory induction of Nox2 led to a superoxide-dependent loss of subsets of inhibitory interneurons in hippocampus, cortex, and amygdala...
  2. The Role of Astrocytes in Cortical Interneuron Development
    KAREN MULLER SMITH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The loss or dysfunction of GABAergic inhibitory interneurons, particularly parvalbumin (PV) expressing interneurons, is implicated in severe psychiatric disorders including schizophrenia, bipolar ..
  3. Dopamine D1 Receptor in mouse models of primary dystonia
    Laurie J Ozelius; Fiscal Year: 2013
    ..Therefore, it is expressed in striatal output medium size spiny neurons and cholinergic interneurons. Abundant evidence supports dysfunction of the basal ganglia in dystonia, although other regions, e.g...
  4. Derivation of cerebral cortical GABAergic interneurons from human iPS cells
    Lorenz P Studer; Fiscal Year: 2010
    ..Specific challenge topic 14-MH-101: Developing iPS cells for mental disorders. Dysfunction of GABAergic interneurons of the cerebral cortex has been implicated in a variety of major neuropsychiatric illnesses, including ..
  5. In vivo targeted gene silencing, a novel method
    WILLIAM ANTHONY TRUITT; Fiscal Year: 2012
    ..A key component of this neural circuit is a discrete population of interneurons containing substance P1 receptors (also known as tachykinin receptor 1;Tacr1) located within the amygdala...
  6. Modeling schizophrenia gamma deficits using cell-specific RNAi knockdown of GAD67
    RITCHIE EDWARD BROWN; Fiscal Year: 2012
    ..postmortem data and animal models of Sz report a partial (30-50%) reduction in GAD67 levels in cortical interneurons expressing the calcium binding protein parvalbumin (PV)...
  7. Dissecting the role of one neuronal RhoGEF amongst many: the Kalirin-7 null mouse
    Richard E Mains; Fiscal Year: 2012
    ..of Kalirin, Kalirin-7, increases the formation of dendritic spines in pyramidal neurons and in normally aspiny interneurons. Reductions in the expression of Kalirin-7 and Kalirin-7 (an N-terminally truncated variant generated from a ..
  8. Epigenome Mapping in Cortical Interneurons
    Schahram Akbarian; Fiscal Year: 2013
    ..genome-wide atlas of the histone methylation landscape in selected subpopulations of cortical GABAergic interneurons and other cells residing in mouse cerebral cortex;and 2) To gain first insights into chromatin remodeling ..
  9. Neuroplasticity with alcohol dependence
    Scott C Steffensen; Fiscal Year: 2013
    ..Dopamine neurotransmission is controlled by local-circuit GABA interneurons. We have identified a homogeneous population of GABA neurons in the VTA that are excited by low-dose ethanol, ..
  10. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..Thalamic interneurons are intriguing in that they give rise to traditional axonal outputs, but also have presynaptic dendrites that ..
  11. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012
    ..and AS also can produce changes in D2 receptor surface distributions in Acb spiny neurons, cholinergic interneurons, and/or dopamine terminals expressing the dopamine transporter (DAT)...
  12. Enhancing Plasticity in Damaged Spinal Cord to Repair Transmission and Function
    Victor L Arvanian; Fiscal Year: 2013
    ..of neurotrophin NT-3 (administered via engineered fibroblasts) and increased function of NMDA receptors in interneurons and motoneurons (using HSV1 viral vector-mediated expression of NMDA receptor NR2D regulatory subunits)...
  13. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..that underlie itch, focusing on signaling mechanisms in primary afferent neurons and spinal cord modulatory interneurons. Somatosensory afferents are activated by itch-producing compounds that are released by a variety of cells in ..
  14. Diet, Insulin, Dopamine, and Reward.
    Margaret E Rice; Fiscal Year: 2013
    ..insulin-enhanced evoked [DA]o is mediated by insulin receptors (InsRs), not on DA axons, but on cholinergic interneurons, and show a pivotal role for DA release regulation by nicotinic acetylcholine (ACh) receptors (nAChRs) located ..
  15. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..receptors in primary afferent nociceptors plays an important role in enhancing DRRs by activating GABAergic interneurons in dorsal horn circuits...
  16. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    ..gamma oscillations are thought to come about as interactions of parvalbumin positive (PV+) fast-spiking (FS) interneurons and pyramidal cells...
  17. Genetic Regulation of Rhombomere Formation
    CHARLES G SAGERSTROM; Fiscal Year: 2013
    ..g. reticulospinal interneurons and motornuclei of the cranial nerves) and is therefore essential for normal neurological activity...
  18. Amphetamine-Induced Transcriptional Plasticity in Striatal GABAergic Interneurons
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..sorting (FACS) to characterize AMPH-induced changes in gene transcription in striatal fast- spiking GABAergic interneurons (FSIs)...
  19. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..IPANs synapse with interneurons and motor neurons creating peristaltic and secremotor responses...
  20. NEUROSECRETORY GENE EXPRESSION IN THE HYPOTHALAMUS
    Pamela L Mellon; Fiscal Year: 2011
    ..neuron is a direct target of steroid hormones as well as responsive to afferent input from steroid- sensitive interneurons. We support this aim with preliminary data that GnRH pulses from GT1 cells are regulated by estrogen and ..
  21. Role of Intronic Variants Affecting Splicing in Juvenile Myoclonic Epilepsy
    Debra J Wolgemuth; Fiscal Year: 2010
    ..Further, our preliminary data show that heterozygous Brd2 mice exhibit a reduction in the number of GABAergic interneurons in the frontal cortex and, strikingly, heterozygous Brd2 mice exhibit an enhanced sensitivity to chemically-..
  22. Characterization of Chd7 in central nervous system neural stem cells
    JOSEPH ANTHONY MICUCCI; Fiscal Year: 2013
    ..The SVZ neural stem cell niche is responsible for producing olfactory bulb (OB) interneurons that play an integral role in olfactory memory and olfactory signal transduction...
  23. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..Thalamic interneurons are intriguing in that they give rise to traditional axonal outputs, but also have presynaptic dendrites that ..
  24. Proinflammatory enzymes in amytrophic lateral sclerosis
    SERGE E PRZEDBORSKI; Fiscal Year: 2012
    ..However, mutant astrocytes do not kill spinal interneurons, which are also spared in the spinal cord of ALS patients...
  25. CELL BIOLOGY OF THE NEURONAL SODIUM CHANNEL
    William A Catterall; Fiscal Year: 2013
    ..All these effects are correlated with loss of Na currents and excitability of GABAergic interneurons, without effects on excitatory neurons, which causes imbalance of excitation vs. inhibition in neural circuits...
  26. Control of Nociception in the Spinal Cord
    Sukhbir S Mokha; Fiscal Year: 2013
    ..to determine whether estrogen receptors co-localize with KOR and ORL1 receptors in projection neurons and/or in interneurons in the dorsal horn of the spinal cord...
  27. Physiological mechanisms responsible for cognitive impairments in Dravet Syndrome
    Pierre Pascal Lenck-Santini; Fiscal Year: 2013
    ..1 are observed in various models of Alzheimer disease (AD). Nav1.1 is highly expressed in inhibitory interneurons that, as we defend here not only explains seizures but also cognitive impairments...
  28. STRESS-OPIOID INTERACTION IN HIPPOCAMPUS
    Teresa A Milner; Fiscal Year: 2013
    ..dendrites of CA3 pyramidal cells;2) increased MORs are present on the plasma membrane of parvalbumin GABAergic interneurons, which inhibit CA3 pyramidal cells;3) fewer DORs are present on the plasma membrane of pyramidal cells;and 4) ..
  29. Somatostain & Stress-Related Genes in HIV & Comorbid Major Depressive Disorder
    Ian Paul Everall; Fiscal Year: 2010
    ..real-time polymerase chain reaction (qRT-PCR), which correlates with the density of calbindin immunopositive interneurons and we noted a significant decrease in the number of cortical somatostatin immunopositive neurons in a ..
  30. Role of Cyclins in Brain Construction and Interneuron Genesis
    KRISTIN GIAMANCO; Fiscal Year: 2013
    ..medial ganglionic eminence (MGE), the origin of cortical parvalbumin (PV)- and somatostatin (SST)-expressing interneurons. We previously showed that cD1 is highly enriched in radial glial cells in the ventricular zone, while cD2 ..
  31. Regulation of Cocaine Reward and Reinforcement by MeCP2
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..phosphorylation of MeCP2 at Ser421 (pMeCP2) selectively in parvalbumin (Pv)-positive fast-spiking GABAergic interneurons (FSIs) in the NAc...
  32. GABA channels and dopamine in striatum
    Stefano Vicini; Fiscal Year: 2013
    ..In addition a small population of GABAergic interneurons controls the excitability of a vast population of MSNs to maintain the proper balance of information outflow ..
  33. The Role of Stress in a Genetically Predisposed Epilepsy Model
    NIKKI TAMARA SAWYER; Fiscal Year: 2013
    ..threshold than their wildtype littermates, and have reduced excitability of cortical GABAergic inhibitory interneurons. This proposal will test the hypothesis that R1648H mutant mice will have altered basal stress system function, ..
  34. Morphogenesis and function of the cerebral cortex
    Flora M Vaccarino; Fiscal Year: 2013
    ..but may increase the differentiation or survival of cortical parvalbumin+ and somatostatin+ inhibitory interneurons by an action in postnatal glial cells...
  35. Trigeminal Mechanisms of Oral Irritation
    Earl Carstens; Fiscal Year: 2009
    ..Additional goals are to test if "chemo- selective" Vc neurons exist, and if interneurons and ascending projection neurons in Vc have similar or different properties. Specific Aim 3...
  36. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..depolarize the excitatory pyramidal neurons directly, and persistently depress excitatory drive to inhibitory interneurons. This combination of effects is relevant to the development of epilepsy because it is expected to drive the ..
  37. Spinal cord injury: Targeting local inhibition to improve outcome
    Linda J Noble; Fiscal Year: 2010
    ..the loss of particular descending axonal pathways most likely results in the decreased activity of inhibitory interneurons, which causes overreaction of motor neurons...
  38. Mechanisms of Valproic Acid-Induced Neurodevelopmental and Behavioral Defects
    Elizabeth M Powell; Fiscal Year: 2013
    ..specific BDNF gene promoters;2) the extent to which the proportions of cortical pyramidal neurons and GABAergic interneurons are altered by embryonic exposure to VPA;and 3) the role of altered BDNF signaling, through the trkB receptor, ..
  39. Roles of Gsh1 &Gsh2 in Telencephalic Neurogenesis
    KENNETH J CAMPBELL; Fiscal Year: 2012
    ..genes, Gsh1 and Gsh2 and their role in the neurogenesis of striatal projection neurons and olfactory bulb interneurons. While striatal neurogenesis occurs exclusively at embryonic time points, olfactory bulb interneurons are ..
  40. MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZE
    Paul J May; Fiscal Year: 2012
    ..This region also contains interneurons including those that utilize the neuropeptide urocortin, which is believed to play a role in stress behaviors...
  41. Alpha4 Nicotinic Receptor in Addiction: Mouse Models
    Henry A Lester; Fiscal Year: 2013
    ..Sub- hypothesis 2.2 states that chronic nicotine upregulates a4* nAChRs in some hippocampal interneurons. Aim 2 also characterizes upregulation in dorsal hippocampus after only 24 hours of nicotine exposure...
  42. CHARACTERIZATION OF NEURAL STEM CELLS IN THE ADULT BRAIN
    Arturo Alvarez-Buylla; Fiscal Year: 2013
    ..rostral migratory stream (RMS) to the olfactory bulb (OB) where they differentiate into multiple types of local interneurons. It remains unknown if B cells self-renew in vivo, how many times C cells divide before they generate new ..
  43. ROLE OF INHIBITION WITHIN THE CEREBELLAR NODULUS/UVULA IN VESTIBULAR PROCESSING
    TATYANA ALEKSANDROVNA YAKUSHEVA; Fiscal Year: 2012
    ..This grant proposal is designed to tackle this question, specifically to investigate the role of GABAergic interneurons within the NU in computing translation...
  44. Chemical Anatomy and Synaptology of Vestibulo-Sympathetic Pathways
    Gay R Holstein; Fiscal Year: 2013
    ..As a result, CVLM cells can be viewed as sympathoinhibitory interneurons in the vasomotor pathway...
  45. Alcohol and Development of the Prefrontal Cortex
    LEON GARLAND COLEMAN; Fiscal Year: 2011
    ..to examine adult frontal cortical structure following prenatal treatment using neuron specific markers for GABA interneurons and pyramidal cells;2...
  46. The Functional Maturation of Inhibitory Interneurons
    MATTHEW LAZARUS; Fiscal Year: 2010
    GABAergic inhibitory interneurons in neocortex are a diverse group of cells that provide precise spatial and temporal control over the activity of local neural circuits...
  47. Mapping the Inputs onto Neocortical Chandelier Cells
    Jason M Tucciarone; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): GABAergic interneurons are crucial in the spatial-temporal regulation of neuronal firing and ensemble activity in cortical circuits...
  48. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2013
    ..These experiments will answer questions like, "Which neurons are the important reflex interneurons for the MOC and MEM reflexes?" and "What types of synapses do the interneurons make on MOC neurons and MEM ..
  49. Regulation of Cholinergic Transmission and Theta Rhythms by Endocannabinoids
    DANIEL ALAN NAGODE; Fiscal Year: 2012
    ..Prior evidence shows that GABAergic interneurons in the hippocampus that co-express the neuropeptide cholecystokinin (CCK+ interneurons), also highly express ..
  50. Structural and Functional Alterations of Interneurons in Models of Schizophrenia
    Istvan Mody; Fiscal Year: 2012
    ..by applicant): Schizophrenia is associated with a reduction in GABA synthesis in a subpopulation of cortical interneurons that express the calcium-binding protein, parvalbumin (PV)...
  51. Chronic nicotine: cell-specific receptor and circuit alterations in basal ganglia
    Henry A Lester; Fiscal Year: 2013
    ..If so, electrochemical detection of DA release will be used. GABAergic interneurons (INs) will be tested for alpha4* receptors, and then for alpha4* up-regulation...
  52. Role NR1/2C and NR1/2D NMDA Receptors in Cortex Function and Memantine Action
    Jon W Johnson; Fiscal Year: 2012
    ..been proposed to result from selective inhibition of NR1/2C and NR1/2D receptor subtypes located on cortical interneurons, resulting in cortical disinhibition...
  53. AFFERENT REGULATION OF CHOLINERGIC FOREBRAIN NEURONS
    Laszlo Zaborszky; Fiscal Year: 2013
    ..The BF contains cholinergic and various non-cholinergic corticopetal neurons and interneurons. The corticopetal BF projections, especially the cholinergic component, have been implicated in memory, sensory ..
  54. Cell type-based genomics of developmental plasticity in cortical GABA interneuron
    Z Josh Huang; Fiscal Year: 2010
    ..the cellular and molecular mechanisms underlying the developmental and experience-dependent maturation of GABA interneurons remain poorly understood...
  55. Glutamate Spillover Transmission in the Cerebellar Cortex
    LUKE TEICHERT CODDINGTON; Fiscal Year: 2013
    ..in the cerebellum mediates communication between excitatory climbing fibers (CFs) and molecular layer interneurons (MLIs), and that this form of signaling occurs in the absence of anatomically-defined synaptic structures...
  56. Nociceptive Role of SST and NT receptor-expressing dorsal horn neurons
    RONALD GORDON WILEY; Fiscal Year: 2013
    ..the therapeutic potential of two neuropeptides, which given intrathecally activate receptors on inhibitory SDH interneurons and produce analgesia in humans, somatostatin (SST), or anti-nociception in animals, neurotensin (NTS)...
  57. Regulatory Effects of Arx Polyalanine Tract Expansion in Murine Brain Development
    MacLean Pancoast; Fiscal Year: 2010
    ..into embryonic male Arx conditional knock- out (CKO) mouse brains, and the characteristics of the CKO interneurons expressing the construct will be compared to interneurons not expressing the construct to determine functions ..
  58. Regulation of Ptf1a in the Developing Nervous System
    David M Meredith; Fiscal Year: 2010
    ..This transcription factor complex is essential for specification of GABAergic/inhibitory interneurons in the dorsal spinal cord, retina, and cerebellum...
  59. Synaptic and Behavioral Correlates of Early Life Stress in the BLA
    Mary Jane Skelly; Fiscal Year: 2013
    ..1 will investigate the effects of social isolation on signaling at BA inhibitory inputs (both local feed-back interneurons and feed-forward lateral paracapsular cells (LPCs)), and determine whether AR facilitation of GABAergic ..
  60. Mechanisms of Central Synaptic Dysfunction in SMA
    GEORGE ZACHARIAS MENTIS; Fiscal Year: 2013
    ..In the spinal cord, motor neurons receive direct synaptic inputs from local interneurons, descending pathways from the brain, and sensory neurons...
  61. Consequences of In Vivo Neocortical GAD67 Downregulation
    Karoly Mirnics; Fiscal Year: 2012
    ..proposal, we hypothesize that in vivo downregulation of GAD67 in SST, NPY, CCK and PARV-containing cortical interneurons will result in distinct anatomical, neurochemical, molecular and behavioral changes that will share common ..
  62. Identifying transcription factors expressed by ventral spinal cord interneurons
    KATHARINE EMMA LEWIS; Fiscal Year: 2013
    ..It will also be invaluable for researchers trying to generate neurons with particular properties from stem cells for therapeutic purposes. ..
  63. Central auditory pathway of the middle ear reflex
    Daniel Lee; Fiscal Year: 2007
    The goal of this project is to understand the anatomic and physiologic features of interneurons of the mammalian middle ear muscle (MEM) reflex pathway...
  64. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..most sensitive; CA3 and granule cells of the dentate gyrus (DG) are resistant to ischemic damage, and GABAergic interneurons in CA1 also survive. The molecular mechanisms underlying this pattern of neuronal death are not well understood...
  65. Interneuronal mechanisms for the control of walking
    Jianguo Cheng; Fiscal Year: 2009
    ..It is critical to understand the properties of interneurons and their interactions within the spinal circuitry in order to unlock this potential...
  66. NEOSTRIATAL CHOLINERGIC INTERNEURONS FIRING PATTERNS
    Charles J Wilson; Fiscal Year: 2010
    Altered function of the neostriatal cholinergic interneurons has been implicated in the pathology of Parkinson's disease, Huntington's disease, and a variety of other disorders...
  67. Kainate Receptors on Hippocampal Interneurons
    Matthew Frerking; Fiscal Year: 2007
    Inhibitory interneurons in the hippocampus regulate pyramidal cells and prevent hyperexcitability that leads to epileptiform activity. Glutamatergic transmission onto interneurons activates these cells to drive these functions...
  68. LONG-TERM DEPRESSION IN HIPPOCAMPAL INTERNEURONS
    JULIE KAUER; Fiscal Year: 1999
    ..Inhibitory interneurons exert powerful control over the electrical output of the hippocampus...
  69. Frequency Dependence of Excitatory Synaptic Transmission
    LYNN DOBRUNZ; Fiscal Year: 2009
    Inhibitory synaptic transmission provided by inhibitory interneurons is essential both for the functioning of neuronal circuits and for normal brain development...
  70. Nigrostriatal Dopamine Function
    JAMES TEPPER; Fiscal Year: 2009
    ..The remaining neurons consist of cholinergic interneurons and 3 types of GABAergic interneurons...
  71. NICOTINIC SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS
    Robert Freedman; Fiscal Year: 2002
    ..Hippocampal interneurons receive a fast, excitatory input via nicotinic synapses that are sensitive to the snake toxin, alpha-..