dendrites

Summary

Summary: Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.

Top Publications

  1. ncbi Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    G Feng
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 28:41-51. 2000
  2. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
  3. ncbi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
  4. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
  5. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
  6. pmc The subcellular organization of neocortical excitatory connections
    Leopoldo Petreanu
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Nature 457:1142-5. 2009
  7. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
  8. ncbi Dendritic organization of sensory input to cortical neurons in vivo
    Hongbo Jia
    Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
    Nature 464:1307-12. 2010
  9. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
  10. ncbi Microtubule assembly, organization and dynamics in axons and dendrites
    Cecilia Conde
    Laboratorio de Neurobiología Celular y Molecular, Instituto Investigación Médica Mercedes y Martín Ferreyra INIMEC CONICET, Friuli 2434, 5016 Cordoba, Argentina
    Nat Rev Neurosci 10:319-32. 2009

Research Grants

  1. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
  2. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
  3. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
  4. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
  5. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
  6. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
  7. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
  8. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
  9. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
  10. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012

Detail Information

Publications385 found, 100 shown here

  1. ncbi Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP
    G Feng
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 28:41-51. 2000
    ..All four XFPs labeled neurons in their entirety, including axons, nerve terminals, dendrites, and dendritic spines...
  2. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
    ..The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior...
  3. ncbi Synaptic integration gradients in single cortical pyramidal cell dendrites
    Tiago Branco
    Wolfson Institute for Biomedical Research, University College London, London, UK
    Neuron 69:885-92. 2011
    ..It is not known if different locations along single cortical dendrites integrate excitatory inputs in different ways...
  4. pmc Structural basis of long-term potentiation in single dendritic spines
    Masanori Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences and The Graduate University of Advanced Studies Sokendai, Myodaiji, Okazaki 444 8787, Japan
    Nature 429:761-6. 2004
    ..They further suggest that small spines are preferential sites for long-term potentiation induction, whereas large spines might represent physical traces of long-term memory...
  5. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
    ....
  6. pmc The subcellular organization of neocortical excitatory connections
    Leopoldo Petreanu
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Nature 457:1142-5. 2009
    ..The dendrites of individual cortical neurons overlap with numerous types of local and long-range excitatory axons, but ..
  7. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
    ..Applying the simplification that synapses between different cell types are made in proportion to the boutons and dendrites that those cell types contribute to the neuropil in a given layer, we were able to estimate the probable source ..
  8. ncbi Dendritic organization of sensory input to cortical neurons in vivo
    Hongbo Jia
    Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
    Nature 464:1307-12. 2010
    ..Here we report a novel approach for the visualization and functional mapping of sensory inputs to the dendrites of cortical neurons in vivo...
  9. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
  10. ncbi Microtubule assembly, organization and dynamics in axons and dendrites
    Cecilia Conde
    Laboratorio de Neurobiología Celular y Molecular, Instituto Investigación Médica Mercedes y Martín Ferreyra INIMEC CONICET, Friuli 2434, 5016 Cordoba, Argentina
    Nat Rev Neurosci 10:319-32. 2009
    ..the current understanding of the regulation of microtubule assembly, organization and dynamics in axons and dendrites. These studies provide new insight into microtubules' function in neuronal development and their potential ..
  11. ncbi Dendritic protein synthesis, synaptic plasticity, and memory
    Michael A Sutton
    Division of Biology 114 96, California Institute of Technology, Howard Hughes Medical Institute, Pasadena, CA 91125, USA
    Cell 127:49-58. 2006
    ..the notion that some of these newly synthesized proteins originate through local translation in neuronal dendrites has gained some traction...
  12. ncbi Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle
    Matthew E Larkum
    Department of Physiology, University of Berne, Buhlplatz 5, 3012 Berne, Switzerland
    Science 325:756-60. 2009
    Tuft dendrites are the main target for feedback inputs innervating neocortical layer 5 pyramidal neurons, but their properties remain obscure...
  13. ncbi TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites
    Myrrhe van Spronsen
    Cell Biology, Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
    Neuron 77:485-502. 2013
    In neurons, the distinct molecular composition of axons and dendrites is established through polarized targeting mechanisms, but it is currently unclear how nonpolarized cargoes, such as mitochondria, become uniformly distributed over ..
  14. ncbi Dendritic discrimination of temporal input sequences in cortical neurons
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Science 329:1671-5. 2010
    ..By applying patterned, two-photon glutamate uncaging, we found that single dendrites of cortical pyramidal neurons exhibit sensitivity to the sequence of synaptic activation...
  15. ncbi Genesis of dendritic spines: insights from ultrastructural and imaging studies
    Rafael Yuste
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nat Rev Neurosci 5:24-34. 2004
  16. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..somatic and dendritic recordings indicate that feed-forward inhibition is much stronger in the soma than in the dendrites, resulting in a broader integration window in the latter compartment...
  17. ncbi Rett syndrome microglia damage dendrites and synapses by the elevated release of glutamate
    Izumi Maezawa
    Department of Pathology, Laboratory Medicine, Medical Investigation of Neurodevelopmental Disorders Institute, University of California Davis Medical Center, Sacramento, California 95817, USA
    J Neurosci 30:5346-56. 2010
    ..Our results suggest that microglia may influence the onset and progression of RTT and that microglia glutamate synthesis or release could be a therapeutic target for RTT...
  18. pmc Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology
    Nurit Ballas
    Howard Hughes Medical Institute, Department of Neurobiology and Behavior, State University of New York, Stony Brook, New York 11794, USA
    Nat Neurosci 12:311-7. 2009
    ..Our studies suggest that astrocytes in the RTT brain carrying MeCP2 mutations have a non-cell autonomous effect on neuronal properties, probably as a result of aberrant secretion of soluble factor(s)...
  19. ncbi Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines
    Hans Zempel
    Max Planck Unit for Structural Molecular Biology, Hamburg, Germany
    J Neurosci 30:11938-50. 2010
    ..Incipient and local changes similar to those of Abeta oligomers can be evoked by cell stressors (e.g., H(2)O(2), glutamate, serum deprivation), suggesting some common mechanism of signaling...
  20. pmc Distinct role of long 3' UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons
    Juan Ji An
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    Cell 134:175-87. 2008
    ..The short 3' UTR mRNAs are restricted to somata, whereas the long 3' UTR mRNAs are also localized in dendrites. In a mouse mutant where the long 3' UTR is truncated, dendritic targeting of BDNF mRNAs is impaired...
  21. pmc An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  22. ncbi A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation
    Aryaman Shalizi
    Department of Pathology, Harvard Medical School, 77 Louis Pasteur Avenue, Boston, MA 02115, USA
    Science 311:1012-7. 2006
    Postsynaptic differentiation of dendrites is an essential step in synapse formation...
  23. pmc Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex
    H Markram
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Germany
    J Physiol 500:409-40. 1997
    ..5. Branching patterns of dendrites and axon collaterals of forty-five synaptically connected neurones, when examined in the light microscope, ..
  24. ncbi Dendritic encoding of sensory stimuli controlled by deep cortical interneurons
    Masanori Murayama
    Physiologisches Institut, Universitat Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Nature 457:1137-41. 2009
    ..The apical dendrites are innervated by local excitatory and inhibitory inputs as well as thalamic and corticocortical projections, ..
  25. ncbi Computational subunits in thin dendrites of pyramidal cells
    Alon Polsky
    Department of Physiology, Technion Medical School, Bat Galim, Haifa 31096, Israel
    Nat Neurosci 7:621-7. 2004
    The thin basal and oblique dendrites of cortical pyramidal neurons receive most of the synaptic inputs from other cells, but their integrative properties remain uncertain...
  26. ncbi Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:6810-8. 2002
    ..Thus, stress-induced structural plasticity in amygdala neurons may provide a candidate cellular substrate for affective disorders triggered by chronic stress...
  27. pmc Branching out: mechanisms of dendritic arborization
    Yuh Nung Jan
    Howard Hughes Medical Institute, Department of Physiology, University of California, 1550 4th Street, San Francisco 94158, USA
    Nat Rev Neurosci 11:316-28. 2010
    ..cytoskeletal elements, Golgi outposts and endosomes have been identified as contributors to the organization of dendrites of individual neurons and the placement of these dendrites in the neuronal circuitry...
  28. pmc Protocadherins mediate dendritic self-avoidance in the mammalian nervous system
    Julie L Lefebvre
    Center for Brain Science and Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA
    Nature 488:517-21. 2012
    ..Deletion of all 22 Pcdh genes in the mouse γ-subcluster (Pcdhg genes) disrupts self-avoidance of dendrites in retinal starburst amacrine cells (SACs) and cerebellar Purkinje cells...
  29. ncbi Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein)
    Tatiana Stepanova
    Medical Genetics Center Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands
    J Neurosci 23:2655-64. 2003
    ..The average speed and length of EB3-GFP movements are comparable in cell bodies, dendrites, axons, and growth cones...
  30. ncbi Pyramidal neurons: dendritic structure and synaptic integration
    Nelson Spruston
    Northwestern University, Department of Neurobiology and Physiology, 2205 Tech Drive, Evanston, Illinois 60208, USA
    Nat Rev Neurosci 9:206-21. 2008
    ..These properties support a variety of coincidence-detection mechanisms, which are likely to be crucial for synaptic integration and plasticity...
  31. pmc Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons
    M Matsuzaki
    Department of Cell Physiology, National Institute for Physiological Sciences, and The Graduate University for Advanced Studies, Myodaiji, Okazaki 444-8585, Japan
    Nat Neurosci 4:1086-92. 2001
    ..Our data indicate that distribution of functional AMPA receptors is tightly correlated with spine geometry and that receptor activity is independently regulated at the level of single spines...
  32. ncbi Actin cytoskeleton regulation in neuronal morphogenesis and structural plasticity
    Liqun Luo
    Department of Biological Sciences, Neurosciences Program, Stanford University, California 94305, USA
    Annu Rev Cell Dev Biol 18:601-35. 2002
    ..the myriad functions of actin and myosin in axon initiation, growth, guidance and branching, in morphogenesis of dendrites and dendritic spines, in synapse formation and stability, and in axon and dendrite retraction...
  33. ncbi Synaptic activation causes the mRNA for the IEG Arc to localize selectively near activated postsynaptic sites on dendrites
    O Steward
    Department of Neuroscience, University of Virginia, Charlottesville 22908, USA
    Neuron 21:741-51. 1998
    Polyribosomal complexes beneath postsynaptic sites on dendrites provide a substrate for local translation of particular mRNAs, but the signals that target mRNAs to synapses remain to be defined...
  34. ncbi Dendritic anomalies in disorders associated with mental retardation
    W E Kaufmann
    Departments of Pathology, Neurology, Pediatrics, and Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine and the Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21205, USA
    Cereb Cortex 10:981-91. 2000
    ..Finally, a model of genotype to neurologic phenotype pathway in MR, centered in dendritic abnormalities, is postulated...
  35. pmc Synaptically driven state transitions in distal dendrites of striatal spiny neurons
    Joshua L Plotkin
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Nat Neurosci 14:881-8. 2011
    ..However, brief glutamate uncaging at spines on distal dendrites evoked somatic up states lasting hundreds of milliseconds...
  36. pmc Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity
    S Hattar
    Howard Hughes Medical Institute and Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Science 295:1065-70. 2002
    ..By cloning rat melanopsin and generating specific antibodies, we show that melanopsin is present in cell bodies, dendrites, and proximal axonal segments of a subset of rat RGCs...
  37. ncbi Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation
    Wenqin Hu
    Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Nat Neurosci 12:996-1002. 2009
    ..Further modeling studies and simultaneous somatic and axonal recordings showed that distal Na(v)1.6 promotes action potential initiation, whereas proximal Na(v)1.2 promotes its backpropagation to the soma...
  38. ncbi Diversity and dynamics of dendritic signaling
    M Hausser
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Science 290:739-44. 2000
    ..between neurons in the brain occurs primarily through synapses made onto elaborate treelike structures called dendrites. New electrical and optical recording techniques have led to tremendous advances in our understanding of how ..
  39. pmc BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory?
    Yuan Lu
    Gene, Cognition and Psychosis Program GCAP, NIMH, National Institutes of Health, Bethesda, MD 20892 3714, USA
    Neurobiol Learn Mem 89:312-23. 2008
    ..Given that BDNF needs to be processed in Golgi outposts localized at the branch point of one or few dendrites, a conceptually challenging problem is how locally synthesized BDNF in dendrites could ensure synapse-specific ..
  40. ncbi Dendritic peptide release and peptide-dependent behaviours
    Mike Ludwig
    Laboratory of Neuroendocrinology, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK
    Nat Rev Neurosci 7:126-36. 2006
    Neuropeptides that are released from dendrites, such as oxytocin and vasopressin, function as autocrine or paracrine signals at their site of origin, but can also act at distant brain targets to evoke long-lasting changes in behaviour...
  41. ncbi Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
    Joshua T Trachtenberg
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    Nature 420:788-94. 2002
    ..Our measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits...
  42. pmc Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala
    Rupshi Mitra
    National Centre for Biological Sciences, Bangalore 560065, India
    Proc Natl Acad Sci U S A 102:9371-6. 2005
    ..the duration of immobilization stress, it is possible to induce the formation of new spines without remodeling dendrites. However, unlike CIS-induced spine formation, the gradual increase in spine density 10 d after a single exposure ..
  43. pmc γ-protocadherins control cortical dendrite arborization by regulating the activity of a FAK/PKC/MARCKS signaling pathway
    Andrew M Garrett
    Department of Biology, Neuroscience Graduate Program, The University of Iowa, Iowa City, IA 52242, USA
    Neuron 74:269-76. 2012
    ..Our results reveal a distinct role for the γ-Pcdhs in cortical development and identify a signaling pathway through which they play this role...
  44. ncbi Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway
    Jacek Jaworski
    The Picower Institute for Learning and Memory, The Institute of Physical and Chemical Research RIKEN, Massachusetts Institute of Technology Neuroscience Research Center, Cambridge, Massachusetts 02139, USA
    J Neurosci 25:11300-12. 2005
    ..kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) signaling pathway promotes the growth and branching of dendrites in cultured hippocampal neurons...
  45. pmc Active properties of motoneurone dendrites: diffuse descending neuromodulation, focused local inhibition
    C J Heckman
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60126, USA
    J Physiol 586:1225-31. 2008
    The dendrites of spinal motoneurones are highly active, generating a strong persistent inward current (PIC) that has an enormous impact on processing of synaptic input...
  46. pmc A centrosomal Cdc20-APC pathway controls dendrite morphogenesis in postmitotic neurons
    Albert H Kim
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Cell 136:322-36. 2009
    ..polyubiquitination of Cdc20, stimulates the activity of centrosomal Cdc20-APC, and drives the differentiation of dendrites. These findings define a postmitotic function for Cdc20-APC in the morphogenesis of dendrites in the mammalian ..
  47. ncbi Large-scale morphological survey of mouse retinal ganglion cells
    Wenzhi Sun
    Institute of Neuroscience and Shanghai Research Center for Life Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, People s Republic of China
    J Comp Neurol 451:115-26. 2002
    ....
  48. pmc Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
    Joshua J Breunig
    Department of Neurobiology, Kavli Institute for Neuroscience, and Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20558-63. 2007
    ..These results provide evidence for the expansive prevalence of Notch signaling in hippocampal morphogenesis and plasticity, suggesting that Notch1 could be a target of diverse traumatic and environmental modulators of adult neurogenesis...
  49. ncbi Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly
    S Lawrence Zipursky
    Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, 90095, USA
    Cell 143:343-53. 2010
    ..Although these properties suggest that Dscams and Pcdhs could act as specificity molecules, they may do so in ways that challenge traditional views of how neural circuits assemble...
  50. ncbi NMDA spikes in basal dendrites of cortical pyramidal neurons
    J Schiller
    Department of Physiology and Biophysics, Technion Medical School, Bat Galim, Haifa, Israel
    Nature 404:285-9. 2000
    Basal dendrites are a major target for synaptic inputs innervating cortical pyramidal neurons. At present little is known about signal processing in these fine dendrites...
  51. ncbi Directionally selective calcium signals in dendrites of starburst amacrine cells
    Thomas Euler
    Max Planck Institute for Medical Research, Jahnstrasse 29, D 69120 Heidelberg, Germany
    Nature 418:845-52. 2002
    ..This demonstrates that direction selectivity is computed locally in dendritic branches at a stage before ganglion cells...
  52. ncbi A new cellular mechanism for coupling inputs arriving at different cortical layers
    M E Larkum
    Abt Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    Nature 398:338-41. 1999
    Pyramidal neurons in layer 5 of the neocortex of the brain extend their axons and dendrites into all layers. They are also unusual in having both an axonal and a dendritic zone for the initiation of action potentials...
  53. ncbi Activity-dependent clustering of functional synaptic inputs on developing hippocampal dendrites
    Thomas Kleindienst
    Netherlands Institute for Neuroscience, 1105 BA Amsterdam, The Netherlands
    Neuron 72:1012-24. 2011
    ....
  54. ncbi The single dendritic branch as a fundamental functional unit in the nervous system
    Tiago Branco
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Curr Opin Neurobiol 20:494-502. 2010
    The conventional view of dendritic function is that dendrites collect synaptic input and deliver it to the soma...
  55. pmc Democracy-independence trade-off in oscillating dendrites and its implications for grid cells
    Michiel W H Remme
    Group for Neural Theory, Departement d Etudes Cognitives, Ecole Normale Superieure, 29 rue d Ulm, 75005 Paris, France
    Neuron 66:429-37. 2010
    ..Our results suggest a fundamental trade-off between local and global processing in dendritic trees integrating ongoing signals...
  56. ncbi Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
    Silvana B Rosso
    Department of Anatomy and Developmental Biology, Rockefeller Building, University College London, University Street, London WC1E 6BT, UK
    Nat Neurosci 8:34-42. 2005
    ..These findings demonstrate a new function for the non-canonical Wnt pathway in dendrite development and identify Dvl as a regulator of Rho GTPases and JNK during dendritic morphogenesis...
  57. ncbi Local caspase activity directs engulfment of dendrites during pruning
    Darren W Williams
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Nat Neurosci 9:1234-6. 2006
    ..Here we show that the removal of sensory neuron dendrites during pruning in Drosophila melanogaster is directed by local caspase activity...
  58. ncbi Experience leaves a lasting structural trace in cortical circuits
    Sonja B Hofer
    Max Planck Institute of Neurobiology, D 82152 Martinsried, Germany
    Nature 457:313-7. 2009
    ..Here we follow spine dynamics on apical dendrites of pyramidal neurons in functionally defined regions of adult mouse visual cortex during plasticity of eye-..
  59. pmc Mef2-mediated transcription of the miR379-410 cluster regulates activity-dependent dendritogenesis by fine-tuning Pumilio2 protein levels
    Roberto Fiore
    Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universitat Heidelberg, and Institut für Neuroanatomie, Universitatsklinikum Heidelberg, Heidelberg, Germany
    EMBO J 28:697-710. 2009
    ..In summary, we have described a novel regulatory pathway that couples activity-dependent transcription to miRNA-dependent translational control of gene expression during neuronal development...
  60. ncbi Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin
    Alexandros Poulopoulos
    Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Neuron 63:628-42. 2009
    ..Deletion of neuroligin 2 in mice perturbs GABAergic and glycinergic synaptic transmission and leads to a loss of postsynaptic specializations specifically at perisomatic inhibitory synapses...
  61. ncbi Genetic interactions between doublecortin and doublecortin-like kinase in neuronal migration and axon outgrowth
    Thomas A S Deuel
    Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Neuron 49:41-53. 2006
    ..Dcx and Dclk may directly or indirectly regulate microtubule-based vesicle transport, a process critical to both neuronal migration and axon outgrowth...
  62. ncbi Chronic behavioral stress induces apical dendritic reorganization in pyramidal neurons of the medial prefrontal cortex
    J J Radley
    Kastor Neurobiology of Aging Laboratories and Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 125:1-6. 2004
    ..affect the morphology of CA3c pyramidal neurons in the rat, by reducing total branch number and length of apical dendrites. In the present study, we investigated the effects of behavioral stress on the mPFC, using the repeated ..
  63. pmc Mechanisms of dendritic mRNA transport and its role in synaptic tagging
    Michael Doyle
    Department of Neuronal Cell Biology, Center for Brain Research, Medical University of Vienna, Austria
    EMBO J 30:3540-52. 2011
    ..This new model integrates our current understanding of synaptic function ranging from synaptic tagging and capture to functional and structural reorganization of the synapse upon learning and memory...
  64. ncbi The mammalian staufen protein localizes to the somatodendritic domain of cultured hippocampal neurons: implications for its involvement in mRNA transport
    M A Kiebler
    European Molecular Biology Laboratory, 69012 Heidelberg, Germany
    J Neurosci 19:288-97. 1999
    In hippocampal neurons, certain mRNAs have been found in dendrites (), and their localization and translation have been implicated in synaptic plasticity ()...
  65. ncbi Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells
    M Megias
    Institute of Experimental Medicine, Hungarian Academy of Sciences, P O Box, H 1450, Budapest, Hungary
    Neuroscience 102:527-40. 2001
    ..A single pyramidal cell has approximately 12,000 microm dendrites and receives around 30,000 excitatory and 1700 inhibitory inputs, of which 40 % are concentrated in the ..
  66. ncbi Activity-dependent dendritic arborization mediated by CaM-kinase I activation and enhanced CREB-dependent transcription of Wnt-2
    Gary A Wayman
    Vollum Institute, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97239, USA
    Neuron 50:897-909. 2006
    ..This novel signaling pathway contributes to dynamic remodeling of the dendritic architecture in response to neuronal activity during development...
  67. pmc Amyloid beta from axons and dendrites reduces local spine number and plasticity
    Wei Wei
    Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    Nat Neurosci 13:190-6. 2010
    ..of either axonal or dendritic Abeta reduced spine density and plasticity at nearby ( approximately 5-10 mum) dendrites. The production of Abeta and its effects on spines were sensitive to blockade of action potentials or nicotinic ..
  68. ncbi Activity-dependent regulation of MEF2 transcription factors suppresses excitatory synapse number
    Steven W Flavell
    Neurobiology Program, Children s Hospital, and Departments of Neurology and Neurobiology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Science 311:1008-12. 2006
    ..These findings define an activity-dependent transcriptional program that may control synapse number during development...
  69. pmc Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis
    Lindsey L Glickfeld
    Department of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 12:21-3. 2009
    ....
  70. ncbi Direct measurement of somatic voltage clamp errors in central neurons
    Stephen R Williams
    Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK
    Nat Neurosci 11:790-8. 2008
    ..These errors question the use of the somatic voltage clamp as a quantitative tool in dendritic neurons...
  71. ncbi Neuronal arithmetic
    R Angus Silver
    Department of Neuroscience, University College, London WC1E 6BT, UK
    Nat Rev Neurosci 11:474-89. 2010
    ....
  72. pmc Differential excitability and modulation of striatal medium spiny neuron dendrites
    Michelle Day
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:11603-14. 2008
    ..How the intrinsic properties of MSN dendrites, where the vast majority of DA receptors are found, contribute to this adaptation is not clear...
  73. pmc Correlations between neuronal morphology and electrophysiological features in the rodent superficial dorsal horn
    T J Grudt
    Department of Cell and Molecular Physiology, University of North Carolina CH, Chapel Hill, NC 27599 7545, USA
    J Physiol 540:189-207. 2002
    ....
  74. ncbi Subunit-specific NMDA receptor trafficking to synapses
    Andres Barria
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Neuron 35:345-53. 2002
    ..Thus, as with AMPA-Rs, synaptic trafficking of NMDA-Rs is tightly regulated and has subunit-specific rules with functionally important consequences...
  75. ncbi Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons
    Dhanrajan M Tiruchinapalli
    Department of Neuroscience, Rose F Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:3251-61. 2003
    ..and three-dimensional reconstruction, ZBP1 was localized in the form of granules that were distributed in dendrites, spines, and subsynaptic sites...
  76. pmc Nectin: an adhesion molecule involved in formation of synapses
    Akira Mizoguchi
    Department of Anatomy and Neurobiology, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    J Cell Biol 156:555-65. 2002
    ..We show here that at the synapses between the mossy fiber terminals and dendrites of pyramidal cells in the CA3 area of adult mouse hippocampus, the nectin-afadin system colocalizes with the ..
  77. ncbi Chronic stress alters dendritic morphology in rat medial prefrontal cortex
    Susan C Cook
    Department of Psychology, Indiana University, Bloomington, Indiana 47405, USA
    J Neurobiol 60:236-48. 2004
    ..Sholl analyses demonstrated a significant alteration of apical dendrites in stressed animals: overall, the number and length of apical dendritic branches was reduced by 18 and 32%, ..
  78. ncbi Identification of sequence motifs that target neuronal nicotinic receptors to dendrites and axons
    Jian Xu
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 26:9780-93. 2006
    ..These results provide valuable information in understanding diverse roles of neuronal nAChRs in mediating and modulating synaptic transmission, synaptic plasticity, and nicotine addiction...
  79. ncbi Mixed microtubules steer dynein-driven cargo transport into dendrites
    Lukas C Kapitein
    Department of Neuroscience, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Curr Biol 20:290-9. 2010
    ..their polarized morphology, neurons employ active transport driven by molecular motors to sort cargo between axons and dendrites. However, the basic traffic rules governing polarized transport on neuronal microtubule arrays are unclear.
  80. pmc miR-124-regulated RhoG reduces neuronal process complexity via ELMO/Dock180/Rac1 and Cdc42 signalling
    Kristin Franke
    Institute of Molecular and Cellular Anatomy, Ulm University, Ulm, Germany
    EMBO J 31:2908-21. 2012
    ..Thus, RhoG emerges as a cellular conductor of Rac1 and Cdc42 activity, in turn regulated by miR-124 to control axonal and dendritic branching...
  81. pmc Enhancer-driven membrane markers for analysis of nonautonomous mechanisms reveal neuron-glia interactions in Drosophila
    Chun Han
    The Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, CA 94143 0725, USA
    Proc Natl Acad Sci U S A 108:9673-8. 2011
    ..live animals, leading to the discovery that glia play critical roles in the severing and degradation of proximal dendrites. The GEEM paradigm should be applicable to the studies of both cell-autonomous and nonautonomous regulations of ..
  82. ncbi Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of glucocorticoid secretion and excitatory amino acid receptors
    A M Magarinos
    Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Neuroscience 69:89-98. 1995
    Repeated restraint stress of rats for 21 days causes atrophy of apical dendrites of hippocampal CA3c pyramidal neurons...
  83. ncbi Principles governing the operation of synaptic inhibition in dendrites
    Albert Gidon
    Department of Neurobiology, Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Neuron 75:330-41. 2012
    ..These results offer new insights into the synergetic effect of dendritic inhibition in controlling dendritic excitability and plasticity and in dynamically molding functional dendritic subdomains and their output...
  84. pmc Reliable coding emerges from coactivation of climbing fibers in microbands of cerebellar Purkinje neurons
    Ilker Ozden
    Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 29:10463-73. 2009
    ..Given the anatomy of the olivocerebellar system, microband synchrony may shape the output of neurons in the cerebellar nuclei either via powerful inhibition by Purkinje cells or by direct monosynaptic excitation from the inferior olive...
  85. pmc RNA-binding protein Sam68 controls synapse number and local β-actin mRNA metabolism in dendrites
    Matthew E Klein
    Dominick P Purpura Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 110:3125-30. 2013
    ..Our research identifies a role for Sam68 in synaptodendritic posttranscriptional regulation of actb and may provide insight into the pathophysiology of fragile X tremor/ataxia syndrome...
  86. ncbi Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation
    K Shen
    Department of Cell Biology and Department of Pharmacology and Cancer Biology, Box 3709, Duke University Medical Center, Durham, NC 27710, USA
    Science 284:162-6. 1999
    ..Autophosphorylation of CaMKII indirectly prolongs its PSD localization by increasing the calmodulin-binding affinity...
  87. pmc Abnormalities of cell packing density and dendritic complexity in the MeCP2 A140V mouse model of Rett syndrome/X-linked mental retardation
    Garilyn M Jentarra
    Neurology Research Department, Barrow Neurological Institute, NRC 438, Phoenix, AZ 85013, USA
    BMC Neurosci 11:19. 2010
    ..Interestingly, this mutation has been reported to preserve the methyl-CpG binding function of the MeCP2 protein while compromising its ability to bind to the mental retardation associated protein ATRX...
  88. pmc Self-avoidance and tiling: Mechanisms of dendrite and axon spacing
    Wesley B Grueber
    Department of Physiology and Cellular Biophysics, Department of Neuroscience, Columbia University Medical Center, New York, New York 10032, USA
    Cold Spring Harb Perspect Biol 2:a001750. 2010
    ..These studies have revealed principles that govern arbor arrangements in dendrites and axons in both vertebrates and invertebrates...
  89. ncbi Dendritic integration in hippocampal dentate granule cells
    Roland Krueppel
    Laboratory for Cognition Research and Experimental Epileptology, Department of Epileptology, University of Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Neuron 71:512-28. 2011
    ..This process is critically determined by the integrative properties of granule cell dendrites. However, their small diameter has so far hampered efforts to examine their properties directly...
  90. ncbi Compartmentalized dendritic plasticity and input feature storage in neurons
    Attila Losonczy
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Dr Ashburn, Virginia 20147, USA
    Nature 452:436-41. 2008
    ....
  91. ncbi Both the establishment and the maintenance of neuronal polarity require active mechanisms: critical roles of GSK-3beta and its upstream regulators
    Hui Jiang
    Institute of Neuroscience, Shanghai Institutes of Biological Sciences, The Graduate School, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China
    Cell 120:123-35. 2005
    ..Here we report a differential distribution of GSK-3beta activity in the axon versus the dendrites. A constitutively active GSK-3beta mutant inhibited axon formation, whereas multiple axons formed from a single ..
  92. ncbi Regulation of dendritic morphogenesis by Ras-PI3K-Akt-mTOR and Ras-MAPK signaling pathways
    Vikas Kumar
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 25:11288-99. 2005
    ..Together, our data underscore the central role of a spatiotemporally regulated key cell survival and growth pathway on trophic regulation of the coordinated development of dendrite size and shape...
  93. ncbi Beta-catenin is critical for dendritic morphogenesis
    Xiang Yu
    Nancy Friend Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304, USA
    Nat Neurosci 6:1169-77. 2003
    ....
  94. ncbi Dendritic computation
    Michael London
    Wolfson Institute for Biomedical Research and Department of Physiology, University College London, London WC1E 6BT, UK
    Annu Rev Neurosci 28:503-32. 2005
    ..Here we review recent work showing that neuronal dendrites exhibit a range of linear and nonlinear mechanisms that allow them to implement elementary computations...
  95. pmc Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons
    Yi Zheng
    Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
    Nat Cell Biol 10:1172-80. 2008
    Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain...
  96. pmc A direct role for FMRP in activity-dependent dendritic mRNA transport links filopodial-spine morphogenesis to fragile X syndrome
    Jason B Dictenberg
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Dev Cell 14:926-39. 2008
    ..These findings highlight a mechanism for stimulus-induced dendritic mRNA transport and link its impairment in a mouse model of FXS to altered developmental morphologic plasticity...
  97. pmc Molecular identity of dendritic voltage-gated sodium channels
    Andrea Lorincz
    Laboratory of Cellular Neurophysiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, 1083 Budapest, Hungary
    Science 328:906-9. 2010
    ..6 subunit in hippocampal CA1 PC proximal and distal dendrites. Here, the subunit density is lower by a factor of 35 to 80 than that found in axon initial segments...
  98. ncbi Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin
    Peter Penzes
    Department of Neuroscience, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Neuron 37:263-74. 2003
    ..This novel signal transduction pathway may be critical for the regulation of the actin cytoskeleton controlling spine morphogenesis during development and plasticity...
  99. ncbi Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons
    M Migliore
    National Research Council, Institute of Advanced Diagnostic Methodologies, Palermo, Italy
    J Comput Neurosci 7:5-15. 1999
    ..could depend on (1) the properties of an A-type K+ conductance that is expressed at high density in hippocampal dendrites and (2) the relative timing of synaptic activation...
  100. ncbi On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons
    Sonia Gasparini
    Neuroscience Center, Louisiana State University Health Science Center, New Orleans, Louisiana 70112, USA
    J Neurosci 24:11046-56. 2004
    Under certain conditions, regenerative voltage spikes can be initiated locally in the dendrites of CA1 pyramidal neurons. These are interesting events that could potentially provide neurons with additional computational abilities...
  101. pmc Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid
    Marta E Soden
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3200, USA
    J Neurosci 30:16910-21. 2010
    ..of retinoic acid (RA), which activates postsynaptic synthesis of AMPA-type glutamate receptors (AMPARs) in dendrites and promotes synaptic insertion of newly synthesized AMPARs...

Research Grants71

  1. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..NKA on development of the neuromuscular junction, the role of the a3 NKA in regulating growth of motor axons and dendrites, and the role of agrin/a3 NKA in modulating neuromuscular synaptic transmission...
  2. Cellular Signaling in Alcoholism
    Subhash C Pandey; Fiscal Year: 2013
    ..spine density (DSD) because it is rapidly induced by synaptic stimulation and is also localized to both dendrites and spines. Arc is also a CREB target gene and is potentially induced by BDNF...
  3. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..We also propose that binding of DAL-1 to SynCAM1 or 2 in dendrites results in formation of an actin/spectrin subsynaptic scaffold...
  4. Electrochemical tools to measure local cerebral blood flow and metabolism
    ROBERT MARK WIGHTMAN; Fiscal Year: 2013
    ..This region contains the dendrites of dopamine neurons and is involved in the regulation of locomotor activity...
  5. Neuroprotection by IFN-beta in AIDS
    Marcus Kaul; Fiscal Year: 2013
    ..MAPK and glycogen synthase kinase (GSK) 32 and hyperphosphorylation of tau, and thus protects neurons and their dendrites and synapses from HIV/gp120-induced damage...
  6. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..In aging rats, chronic ethanol consumption results in regression of Purkinje neuron (PN) dendrites, a process that surely alters cerebellar function as PN are the sole output neurons from the cerebellum...
  7. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..and Eph receptors play an important role in the interactions between glial cells and neuronal axons as well as dendrites in different parts of the central and peripheral nervous system...
  8. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    ..Native neuroprotective mechanisms for the type I afferent dendrites is an issue addressed in the present proposal for the neuropeptide PACAP, important in excitotoxicity and noise-..
  9. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..and Plasticity) focus on cell specification, retinal axon guidance, and biophysics and plasticity of dendrites and cortical circuitry, and are in the departments of Genetics, Pathology and Cell Biology, Neuroscience, and ..
  10. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..interneurons are intriguing in that they give rise to traditional axonal outputs, but also have presynaptic dendrites that spatially overlap with retinal inputs onto dLGN relay neurons...
  11. The survival of motor neuron protein in axonal mRNA localization
    PAUL GREGORY DONLIN-ASP; Fiscal Year: 2013
    ..SMN localizes to axons and dendrites in spinal motor neurons...
  12. Neurochemistry/physiology of proopiomelanocortin neurons
    MALCOLM JAMES LOW; Fiscal Year: 2013
    ..We will also use genetic techniques and multilabel immunohistochemistry to study the unexpectedly complex dendrites of POMC neurons that receive synaptic inputs from distal sites...
  13. Mechanisms and Therapeutics for Rett Syndrome
    Mriganka Sur; Fiscal Year: 2013
    ..Second, we will use two-photon imaging of neurons and their dendrites across time in vivo to evaluate structural correlates of spine maturation...
  14. BRAIN LIPID METABOLISM, DENDRITES AND SYNAPSES IN AGING AND ALZHEIMER'S DISEASE
    Guojun Bu; Fiscal Year: 2013
    ..Our studies may also define apoE and apoE receptors as critical targets for AD therapy. ..
  15. Role of FUS in ALS
    Haining Zhu; Fiscal Year: 2013
    ..is almost exclusively localized to the nucleus but is also reported to transport mRNA for local translation in dendrites in neurons...
  16. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): "Distance-Dependent Structure and Function of Neuronal Dendrites" Neuronal dendrites, axons and synapses are structurally distorted in individuals with mental retardation and other neurological ..
  17. Physiology and structure of prefrontal projections to memory and motor circuits
    Maria Medalla; Fiscal Year: 2013
    ..will be conducted using high-resolution laser-scanning confocal imaging and electron microscopy of filled dendrites. This project will lead to a better understanding of prefrontal cortical microcircuitry and mechanisms ..
  18. Adolescent brains, nicotine and endogenous prototoxins
    Rae Nishi; Fiscal Year: 2010
    ..demonstrate nicotine-induced conditioned place to determine whether changes in arborization of eYFP- labeled dendrites in layer 5 as well as changes in eYFP-terminals in nucleus accumbens occur;to determine if correlative changes ..
  19. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Neuronal dendrites and synapses are structurally distorted in individuals with mental retardation and other neurological disorders...
  20. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2013
    ..taken from post-mortem ferret brains at five ages spanning postnatal day (P)6 to P45, to measurements of FAN of dendrites and axons labeled in the same tissue by the application of Golgi and anatomical tracing procedures...
  21. Chronic imaging of cellular dynamics after cortical microhemorrhage
    Chris B Schaffer; Fiscal Year: 2013
    ..Surprisingly, we found no evidence of neural cell death or pathological changes in dendrites, both of which are observed after occlusion of small arterioles...
  22. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..interneurons are intriguing in that they give rise to traditional axonal outputs, but also have presynaptic dendrites that spatially overlap with retinal inputs onto dLGN relay neurons...
  23. Estrogen and hippocampal plasticity
    LORI LYNN MCMAHON; Fiscal Year: 2012
    ..to the Schaffer collateral pathway but also include synapses between the entorhinal cortex and the distal dendrites of CA1 pyramidal cells;AIM3 will test the hypothesis that cholinergic denervation will prevent the E2 induced ..
  24. STRESS-OPIOID INTERACTION IN HIPPOCAMPUS
    Teresa A Milner; Fiscal Year: 2013
    ..at proestrus (high estrogen): 1) enkephalin levels are elevated in mossy fibers (MFs), which synapse on the dendrites of CA3 pyramidal cells;2) increased MORs are present on the plasma membrane of parvalbumin GABAergic ..
  25. Glutamine Transporters SNAT1 and SNAT2 in Rett Syndrome Microglia
    Izumi Maezawa; Fiscal Year: 2013
    ..excitotoxicity by constitutively releasing five times more glutamate than wild-type microglia, thus damaging dendrites and synapses...
  26. Cytoskeletal Dynamics in Neuronal Dendrites
    Erik W Dent; Fiscal Year: 2013
    ....
  27. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    ..stain, dividing cells by Ki-67 stain, mature neurons by neuronal-specific nuclear protein (NeuN) and their dendrites labeled by and neurofilament stain...
  28. A kinase pathway required for cortical neuron polarization
    Franck Polleux; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The polarization of axon and dendrites underlies the ability of neurons to integrate and transmit information in the brain...
  29. Regulation of Axon Guidance by Second Messengers
    Timothy M Gomez; Fiscal Year: 2013
    ..of neuronal connections that compose the human nervous system occurs through guided extension of axons and dendrites. The long-term objective of our research is to better understand the intracellular signaling cascades and ..
  30. NORADRENERGIC SYSTEM IN DEPRESSION
    GREGORY ALLEN ORDWAY; Fiscal Year: 2012
    ..Finally, the density of neuronal dendrites and glia in the LC will be studied in control and MDD subjects...
  31. MIDBRAIN CIRCUITRY FOR NEURONAL CONTROL OF GAZE
    Paul J May; Fiscal Year: 2012
    ..4 tests whether the tectal projection to the perioculomotor region is part of its conjugate function, with the dendrites of vertical gaze motor neurons being its target, or is a pathway that modulates components of the near response...
  32. Hippocampal dendritic spines tracked in learning and memory processing using in v
    Mark J Schnitzer; Fiscal Year: 2012
    ..spatial organization? For example, we will examine if new spines tend to arise clustered together along the same dendrites. Thus, our aims are: Aim 1: Develop a chronic mouse preparation for time-lapse in vivo microendoscopy imaging of ..
  33. The Role of Cytoplasmic Dynein in Axonal Transport
    KEVIN K PFISTER; Fiscal Year: 2011
    ..We have shown that both are present in neurites, axons, and dendrites. We have prepared a stable neural cell line expressing the ubiquitous isoform tagged with GFP;demonstrated that ..
  34. Homeostatic Regulation of Presynaptic Function by Dendritic mTORC1
    FREDRICK EARL HENRY; Fiscal Year: 2013
    ..The central hypothesis is that postsynaptic mTORC1 signaling regulates a local translational program in dendrites that functions to modulate neurotransmitter release from apposed presynaptic terminals...
  35. The Antidepressant Action of Ketamine:Brain Chemistry
    MATE ISTVAN MILAK; Fiscal Year: 2013
    ..signaling is activated, within minutes a rapid increase in synaptic signaling proteins, the number of new spine dendrites, synaptogenesis, and increased motor activity in animal models of depression ensues...
  36. Control of Excitatory Synapse Formation and Maturation by Astrocytes
    WILLIAM CHRISTOPHER RISHER; Fiscal Year: 2013
    ..to determine the role of TSP in forming the initial synaptic contacts between presynaptic axons and postsynaptic dendrites. Intriguingly, TSP binds to the neuronal calcium channel subunit a2d-1 to stimulate the formation and target-..
  37. Motley Diversity Supplement
    Edwin W Rubel; Fiscal Year: 2013
    ..between afferent stimulation, calcium homeostasis, calcium regulatory proteins and structural dynamics of dendrites. PUBLIC HEALTH RELEVANCE: This project encompasses three interrelated areas: development of auditory information ..
  38. A role for ephrins-A2, -A3, &-A5 in excitatory synaptic development and function
    Rachel Wurzman; Fiscal Year: 2013
    ..examine changes in glutamate receptor trafficking and stereological studies of morphology to measure changes in dendrites of medium spiny neurons (MSNs), the main projection neurons in the striatum...
  39. AKAP Regulation of Neuronal L-type Calcium Channel Signaling to the Nucleus
    MARK L DELL'ACQUA; Fiscal Year: 2013
    ..The primary question in synapse-to-nucleus signaling is how local Ca2+ signals generated in dendrites are relayed remotely to the nucleus in the soma...
  40. Structure-function analysis of zebrafish encoded 3-OST enzyme for HSV-1 Entry
    Vaibhav Tiwari; Fiscal Year: 2011
    ..of ZF embryo infected with HSV-1 leads to extensive dendrite formation followed by cell damage which mimics the dendrites of herpetic stromal keratitis (HSK) reported in human cornea infected with HSV-1...
  41. The Functional Maturation of Inhibitory Interneurons
    MATTHEW LAZARUS; Fiscal Year: 2010
    ..and somatostatin expressing cells, which have a regular-spiking phenotype and provide distal inhibition to the dendrites. The activity-dependence of inhibitory circuit formation will be studied by manipulating the two glutamic acid ..
  42. Fibrinogen as a molecular mediator of cognitive dysfunction
    Frances Alexandra Loucks; Fiscal Year: 2010
    ..decreases dendritic spine density in mice;and (4) cortical neurons treated with fibrinogen in vitro have thicker dendrites than controls...
  43. Optical studies of the cone photoreceptor synapse
    Richard H Kramer; Fiscal Year: 2013
    ..ephaptic" hypothesis with "caged" glutamate receptor agonists to locally alter current flow into individual dendrites of HCs...
  44. Epithelia Associated Dendritic Cells: Phenotype and Function
    Rodney D Newberry; Fiscal Year: 2010
    ..These DCs extend dendrites into the intestinal lumen to sample and respond to stimuli and because of their physical location these DCs have ..
  45. FUNCTIONAL ANALYSIS OF CALCIUM CHANNEL MUTATIONS IN TRIGEMINAL NOCICEPTION
    Yuqing Cao; Fiscal Year: 2010
    ..is critical for neurotransmitter release at presynaptic terminals and postsynaptic Ca2+ signaling in soma and dendrites. The discovery of multiple 1A mutations in FHM-1 patients provides a platform for elucidating the mechanism ..
  46. Regulation of dendritic spine shape and synapse and dendrite stability by Arg
    Anthony J Koleske; Fiscal Year: 2012
    ..b>Dendrites and synapses develop normally through postnatal day 21 in the arg-/- mouse cortex and hippocampus, but dendritic ..
  47. Polyphenolic Interventions for tau Pathogenesis in Alzheimers Models
    SALLY ANN FRAUTSCHY; Fiscal Year: 2013
    ..4. Curcumin, but not fisetin will reduce total fyn, tau oligomers, the redistribution of CP13 ptau to dendrites as well as synaptic and cognitive deficits, but not NFT and insoluble tau. 5...
  48. TRP channel expression and function in ON-bipolar cells
    Robert M Duvoisin; Fiscal Year: 2012
    ..cell signaling pathway originates with a unique metabotropic glutamate receptor, mGluR6, which is found on the dendrites of ON-bipolar cells...
  49. IMMATURE HIPPOCAMPUS: EPILEPTOGENIC PROPERTIES
    JOHN WILLIAM SWANN; Fiscal Year: 2012
    ..that the primary deficit produced by epileptiform activity was not on glutamatergic synaptic transmission but on dendrites. Further studies confirmed this and showed that chronic disinhibition actually prevents the growth of dendrites ..
  50. Profiling and characterizing axonal precursor micro RNAs in regenerating nerve
    Soonmoon Yoo; Fiscal Year: 2013
    ..miRISC) that are required for processing precursor miRNAs (pre- miRNAs) to mature functional miRNAs both in dendrites and axons...
  51. Mechanisms of Central Synaptic Dysfunction in SMA
    GEORGE ZACHARIAS MENTIS; Fiscal Year: 2013
    ..1, we will analyze the functional effects of a neuronal population that makes direct synapses on the somata and dendrites of spinal motor neurons in SMA mice...
  52. The roles of Gbeta5 and R7 RGS protein in vision
    Ching Kang Jason Chen; Fiscal Year: 2013
    ..3) abnormal ribbon synapses at outer plexiform layer (OPL) with unincorporated depolarizing bipolar cells (DBC) dendrites~ 4) lack of electroretinography (ERG) b-waves~ 5) reduction of starburst amacrine cell (SAC) dendritic field, 6) ..
  53. Regulation of Local BDNF Synthesis in Dendrites
    Baoji Xu; Fiscal Year: 2010
    ..binding protein and has been shown to stabilize select mRNA species and to repress local protein synthesis in dendrites. However, its role in dendritic targeting of mRNAs remains to be determined, although it is associated with ..
  54. Corticolimbic Somatostatin-Related Inhibitory Dysfunction in Major Depression
    Etienne L Sibille; Fiscal Year: 2013
    ..At the microcircuitry level, SST GABA neurons target the distal dendrites of pyramidal neurons, but different subsets of SST neurons display different anatomical localizations and ..
  55. Mechanisms of Synaptic Integration in Central Neurons
    William J Spain; Fiscal Year: 2012
    ..The second set of experiments uses photolysis to uncage glutamate to stimulate the dendrites. In the third set of experiments we simultaneously record from synaptically connected pairs of neurons...
  56. Development of genetically encoded neural tracers for electron microscopy
    Linnaea E Ostroff; Fiscal Year: 2012
    ..This will allow identification of the axons and dendrites of cells activated during learning and plasticity experiments such that their synapses can be specifically ..
  57. Understanding the Role of Epac2 in Cognitive Function
    Ruoqi Gao; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dendritic spines are tiny protrusions on dendrites and are the sites of most excitatory synapses in the mammalian brain...
  58. Development and Plasticity of a Retinotectal System
    Mu ming Poo; Fiscal Year: 2012
    ..and the role of ephrin-B1/EphB2 signaling in modulating the arbor dynamics of both RGC axons and tectal cell dendrites. In Aim 3, we will examine whether ephrin-B1/EphB2 signaling contributes to the developmental reduction of the ..
  59. mTOR dysregulation in Epilepsy
    Angela N Carter; Fiscal Year: 2013
    ..mTORC1 regulates these aspects of dendrites under physiological conditions, suggesting that hyperactivation of mTORC1 signaling may promote epilepsy and the ..
  60. GENETIC ANALYSIS OF OLFACTION
    Dean P Smith; Fiscal Year: 2013
    ..The first aim is to further define what activated LUSH interacts with on the T1 dendrites in the pheromone detection cascade...
  61. Regulation of kinesin-5 during neuronal development: studies on dendrites
    OLGA IGOREVNA KAHN; Fiscal Year: 2013
    ..possess one long thin axon with a uniformly plus-end-distal microtubule array and several short thick tapering dendrites with mixed polarity microtubule array...
  62. Motor Neuron Disease in Mouse Models of ALS: Where Does The End Begin
    Carol Milligan; Fiscal Year: 2013
    ..ultrastructual changes occur throughout the motoneurons (MNs) from neuromuscular presynaptic terminal to distal dendrites. We propose to identify and characterize the earliest pathological changes that occur and to determine the order ..
  63. Postsynaptic Activity of Type II Cochlear Afferents
    CATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2010
    ..We have developed a technique that allows gigaohm-seal intracellular recordings in Type II afferent dendrites near their synaptic inputs...
  64. MONOCLONAL ANTIBODY PROBES FOR NEUROFILAMENT PROCESSING
    LUDWIG STERNBERGER; Fiscal Year: 1991
    ..Immunocytochemically, 5 of these antibodies stained long fiber tracts and terminal axons but not cell bodies, dendrites or proximal axons (group II), 4 stained cell bodies, dendrites and proximal axons but not terminal axons (group ..
  65. Effects--Ethanol--Dendritic Smooth Endoplasmic Reticulum
    Cynthia Dlugos; Fiscal Year: 2003
    ..The SER within PN dendrites stores calcium ions, a function that may be upset by ethanol-related imbalances...
  66. PROTEOMIC ANALYSIS OF OSTEOCYTES
    Norman Karin; Fiscal Year: 2009
    ..Osteocytes are characterized by membrane extensions (dendrites) with which these cells communicate with neighboring osteocytes and osteoblasts...
  67. NMDA RECEPTOR IN LEAD INDUCED COGNITIVE DEFICIT
    EDSON ALBUQUERQUE; Fiscal Year: 1999
    ..NMDA receptors and nAChRs restricted during development to particular neuronal regions, such as apical and basal dendrites, in distinct hippocampal areas (CA1, CA3, or dentate gyrus)? To answer this questions we will use state-of-the-..
  68. SPINE AND SYNAPTIC PLASTICITY IN MATURE HIPPOCAMPUS
    Kristen Harris; Fiscal Year: 2003
    ..Instead we have discovered that dendrites of mature neurons become more spiny within hours after synapses are inactivated...
  69. LOCALIZATION OF MRNAS AT SYNAPTIC SITES ON DENDRITES
    Oswald Steward; Fiscal Year: 2011
    ..the mechanisms and functional role of mRNA localization and local translation at synaptic sites on neuronal dendrites. Local synthesis of critical proteins at synapses is necessary for long-lasting forms of synaptic plasticity ..
  70. BETA-ACTIN MRNA LOCALIZATION
    GARY BASSELL; Fiscal Year: 2002
    ..asymmetric cell and differentiate two morphologically and functionally distinct types of processes: axons and dendrites. The development of the nervous system proceeds by the extension of axons over long distances to reach their ..
  71. Active Dendrites in Motor Neurons
    ROGER ENOKA; Fiscal Year: 2004
    ..In recent years, however, it has become evident that he dendrites of motor neurons do not act as passive recipients of synaptic input; they contain voltage-sensitive onductances ..