vestibular hair cells

Summary

Summary: Mechanoreceptors located in the acoustic maculae and the semicircular canals that mediate the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the VESTIBULOCOCHLEAR NERVE to the brain stem.

Top Publications

  1. ncbi Depolarization redistributes synaptic membrane and creates a gradient of vesicles on the synaptic body at a ribbon synapse
    David Lenzi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Neuron 36:649-59. 2002
  2. ncbi The coupling of acetylcholine-induced BK channel and calcium channel in guinea pig saccular type II vestibular hair cells
    Wei Jia Kong
    Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wu Han, 430022, People s Republic of China
    Brain Res 1129:110-5. 2007
  3. ncbi Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis
    M Zhang
    Center for Hearing and Deafness, Hearing Research Laboratory, 215 Parker Hall, University at Buffalo, Buffalo, NY 14214, USA
    Neuroscience 120:191-205. 2003
  4. ncbi The properties of ACh-induced BK currents in guinea pig type II vestibular hair cells
    Wei Jia Kong
    Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Hear Res 209:1-9. 2005
  5. pmc The septate junction protein caspr is required for structural support and retention of KCNQ4 at calyceal synapses of vestibular hair cells
    Aurea D Sousa
    Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 29:3103-8. 2009
  6. ncbi Neural connections between embryonic stem cell-derived neurons and vestibular hair cells in vitro
    Tae Soo Kim
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    Brain Res 1057:127-33. 2005
  7. ncbi Effects of KCNQ channel blockers on K(+) currents in vestibular hair cells
    K J Rennie
    Department of Otolaryngology, The University of Texas Medical Branch, Galveston, Texas 77555 1063, USA
    Am J Physiol Cell Physiol 280:C473-80. 2001
  8. ncbi The effect of proteolytic enzymes on the alpha9-nicotinic receptor-mediated response in isolated frog vestibular hair cells
    J C Holt
    Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Hear Res 152:25-42. 2001
  9. ncbi Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation
    Marta Martini
    Dipartimento di Biologia ed Evoluzione, Sezione di Fisiologia e Biofisica, e Centro di Neuroscienze, Universita di Ferrara, Via L Borsari 46, Ferrara, Italy
    Eur Biophys J 36:779-86. 2007
  10. pmc Muscarinic acetylcholine receptor subtype expression in avian vestibular hair cells, nerve terminals and ganglion cells
    G Q Li
    Department of Otolaryngology, University of Texas Medical Branch at Galveston, Galveston, TX 77550 1063, USA
    Neuroscience 146:384-402. 2007

Detail Information

Publications211 found, 100 shown here

  1. ncbi Depolarization redistributes synaptic membrane and creates a gradient of vesicles on the synaptic body at a ribbon synapse
    David Lenzi
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Neuron 36:649-59. 2002
    ..We conclude that formation of new synaptic vesicles from cisterns is rate limiting in the vesicle cycle...
  2. ncbi The coupling of acetylcholine-induced BK channel and calcium channel in guinea pig saccular type II vestibular hair cells
    Wei Jia Kong
    Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wu Han, 430022, People s Republic of China
    Brain Res 1129:110-5. 2007
    ..However, the functional roles of ACh in type II vestibular hair cells (VHCs II) among mammalians are still unclear, with the exception of the well-known alpha9-containing ..
  3. ncbi Pifithrin-alpha suppresses p53 and protects cochlear and vestibular hair cells from cisplatin-induced apoptosis
    M Zhang
    Center for Hearing and Deafness, Hearing Research Laboratory, 215 Parker Hall, University at Buffalo, Buffalo, NY 14214, USA
    Neuroscience 120:191-205. 2003
    ..that the tumor suppressor protein, p53, plays a critical role in initiating apoptosis in cochlear and vestibular hair cells. Temporary suppression of p53 with PFT provides significant protection against cisplatin-induced hair cell ..
  4. ncbi The properties of ACh-induced BK currents in guinea pig type II vestibular hair cells
    Wei Jia Kong
    Department of Otolaryngology, Union Hospital of Tongji Medical College, Hua Zhong University of Science and Technology, Wuhan, Hubei, People s Republic of China
    Hear Res 209:1-9. 2005
    ..ACh)-induced currents were investigated by whole-cell patch clamp technique in isolated type II vestibular hair cells (VHCs II) of guinea pig...
  5. pmc The septate junction protein caspr is required for structural support and retention of KCNQ4 at calyceal synapses of vestibular hair cells
    Aurea D Sousa
    Laboratory of Cell Structure and Dynamics, National Institute on Deafness and Other Communication Disorders National Institutes of Health, Bethesda, Maryland 20892 8027, USA
    J Neurosci 29:3103-8. 2009
    ..Our results indicate that a septate-like junction provides structural support to calyceal synaptic contact with the vestibular hair cell and that Caspr is required for the recruitment or retention of KCNQ4 at these synapses...
  6. ncbi Neural connections between embryonic stem cell-derived neurons and vestibular hair cells in vitro
    Tae Soo Kim
    Department of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kawaharacho 54, Shogoin, Sakyo ku, 606 8507 Kyoto, Japan
    Brain Res 1057:127-33. 2005
    ..Histological analyses demonstrated that ESC-derived neurons substantially elongated their neurites towards vestibular hair cells, and attached to hair cells at the regions corresponding to the location of nerve endings in normal ..
  7. ncbi Effects of KCNQ channel blockers on K(+) currents in vestibular hair cells
    K J Rennie
    Department of Otolaryngology, The University of Texas Medical Branch, Galveston, Texas 77555 1063, USA
    Am J Physiol Cell Physiol 280:C473-80. 2001
    ..These results suggest that KCNQ channels may be present in amniote vestibular hair cells.
  8. ncbi The effect of proteolytic enzymes on the alpha9-nicotinic receptor-mediated response in isolated frog vestibular hair cells
    J C Holt
    Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Hear Res 152:25-42. 2001
    ..The mechanism by which these enzymes render saccular hair cells unresponsive to acetylcholine remains unknown, but it most likely involves proteolysis of alpha9nAChR, SK, or both...
  9. ncbi Ca2+ current of frog vestibular hair cells is modulated by intracellular ATP but not by long-lasting depolarisation
    Marta Martini
    Dipartimento di Biologia ed Evoluzione, Sezione di Fisiologia e Biofisica, e Centro di Neuroscienze, Universita di Ferrara, Via L Borsari 46, Ferrara, Italy
    Eur Biophys J 36:779-86. 2007
    ..The outward current waveform could be erroneously ascribed to a Ca- and/or voltage dependence of the Ca(2+) macrocurrent...
  10. pmc Muscarinic acetylcholine receptor subtype expression in avian vestibular hair cells, nerve terminals and ganglion cells
    G Q Li
    Department of Otolaryngology, University of Texas Medical Branch at Galveston, Galveston, TX 77550 1063, USA
    Neuroscience 146:384-402. 2007
    ..1) ionic currents in native vestibular hair cells. We have cloned and sequenced pigeon mAChR subtypes M2-M5 and we have studied the expression of all five ..
  11. pmc Myosin XVa localizes to the tips of inner ear sensory cell stereocilia and is essential for staircase formation of the hair bundle
    Inna A Belyantseva
    Laboratory of Molecular Genetics, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, 5 Research Court, Rockville, MD 20850, USA
    Proc Natl Acad Sci U S A 100:13958-63. 2003
    ..rat, and guinea pig, endogenous myosin XVa localizes to the tips of the stereocilia of the cochlear and vestibular hair cells. Myosin XVa localization overlaps with the barbed ends of actin filaments and extends to the apical plasma ..
  12. ncbi Presynaptic calcium stores modulate afferent release in vestibular hair cells
    Andrea Lelli
    Venetian Institute of Molecular Medicine, via Giuseppe Orus 2, 35129 Padua, Italy
    J Neurosci 23:6894-903. 2003
    ..at the presynaptic level, by monitoring changes in the intracellular Ca2+ concentration ([Ca2+]i) in vestibular hair cells, and, at the postsynaptic level, by recording from single posterior canal afferent fibers...
  13. ncbi Modulation of voltage-gated Ca2+ current in vestibular hair cells by nitric oxide
    Angélica Almanza
    Instituto de Fisiologia, Universidad Autonoma de Puebla, Puebla 72000, Mexico
    J Neurophysiol 97:1188-95. 2007
    ..demonstrated that NO inhibits in a voltage-independent manner the voltage-activated Ca(2+) current in rat vestibular hair cells by the activation of a cGMP-signaling pathway and through a direct action on the channel protein by a S-..
  14. pmc Fast adaptation in vestibular hair cells requires myosin-1c activity
    Eric A Stauffer
    Department of Neuroscience and Department of Otolaryngology, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    Neuron 47:541-53. 2005
    ..In frog and mouse vestibular hair cells, we found that the rate of fast adaptation depends on both channel opening and stimulus size and that it ..
  15. ncbi Cytochrome c redistribution in apoptosis of guinea pig vestibular hair cells
    T Nakagawa
    Department of Otorhinolaryngology, Yodogawa Christian Hospital, 2 9 26 Awaji, Higashiyodogawaku, 533 0032, Osaka, Japan
    Brain Res 847:357-9. 1999
    We examined the cellular location of cytochrome c in healthy and in streptomycin-damaged vestibular hair cells by immunohistochemistry...
  16. ncbi Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants
    T Nicolson
    Max Planck Institut fur Entwicklungsbiologie, Abteilung Genetik, Tubingen, Federal Republic of Germany
    Neuron 20:271-83. 1998
    ..The microphonics of lateral line hair cells of orbiter, mercury, and gemini larvae are absent or strongly reduced. Therefore, these genes may encode components of the transduction apparatus...
  17. ncbi Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine
    Sonja F Arab
    Department of Oto Laryngology and Plastic Head and Neck Surgery, University Hospital Aachen, 52057 Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 369:570-5. 2004
    ..We hypothesized that cinnarizine, as a blocker of L-type Ca2+ channels, may directly target vestibular hair cells where Ca2+ currents are important for the mechano-electrical transduction and transmitter release...
  18. ncbi The motor and tail regions of myosin XV are critical for normal structure and function of auditory and vestibular hair cells
    D W Anderson
    Laboratory of Molecular Genetics and Laboratory of Cell Biology, NIDCD, Rockville, MD 20850, USA
    Hum Mol Genet 9:1729-38. 2000
    ..Both the shaker 2 and shaker 2(J) alleles result in abnormally short hair cell stereocilia in the cochlear and vestibular systems. This suggests that Myo15 may be important for both the structure and function of these sensory epithelia...
  19. ncbi E-cadherin and the differentiation of mammalian vestibular hair cells
    Lucy Hackett
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom
    Exp Cell Res 278:19-30. 2002
    ..Down-regulation of E-cadherin is thus likely to be a key element in the regeneration of hair cells...
  20. ncbi Opioid receptors mediate a postsynaptic facilitation and a presynaptic inhibition at the afferent synapse of axolotl vestibular hair cells
    R Vega
    Instituto de Fisiologia, Universidad Autonoma de Puebla, 14 Sur 6301, CU, Puebla, 72570, Pue, Mexico
    Neuroscience 118:75-85. 2003
    ....
  21. ncbi Effects of cinnarizine on calcium and pressure-dependent potassium currents in guinea pig vestibular hair cells
    Philip Düwel
    Institute of Physiology, Medical Faculty, RWTH Aachen, 52057 Aachen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 371:441-8. 2005
    In vestibular hair cells, K+ currents induced by rises in hydrostatic pressure have recently been demonstrated. These currents are inhibited by charybdotoxin, a blocker of Ca2+-dependent K+ channels...
  22. ncbi Bcl-2 gene therapy prevents aminoglycoside-induced degeneration of auditory and vestibular hair cells
    Susanna C Pfannenstiel
    Department of Otolaryngology Head and Neck Surgery, University of Kansas, School of Medicine, Kansas City, Kans 66160, USA
    Audiol Neurootol 14:254-66. 2009
    ..Pretreatment with Ad.11D.bcl-2 resulted in morphologic protection of hair cells and preservation of hearing thresholds measured by ABR...
  23. ncbi Histology of the utricle in kinetotically swimming fish: a parabolic aircraft flight study
    Annegret Bäuerle
    Zoological Institute, University of Stuttgart Hohenheim, Stuttgart, Germany
    Acta Otolaryngol 124:19-22. 2004
    ....
  24. ncbi Vestibulo-ocular physiology underlying vestibular hypofunction
    Michael C Schubert
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 710 Ross Bldg, 720 Rutland Ave, Baltimore, MD 21205, USA
    Phys Ther 84:373-85. 2004
    ..The purposes of this article are to review the anatomy and physiology of the vestibular system and to describe the neurophysiological mechanisms responsible for the vestibulo-ocular abnormalities in patients with vestibular hypofunction...
  25. ncbi Hair bundle heights in the utricle: differences between macular locations and hair cell types
    Jingbing Xue
    Department of Biological Sciences, Irvine Hall, Ohio University, Athens, OH 45701, USA
    J Neurophysiol 95:171-86. 2006
    ....
  26. ncbi Ototoxicity of carboplatin delivered locally in a monkey brainstem
    J P Carey
    Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins School of Medicine, 600 N Wolfe Street, Suite 811 Harvey, Baltimore, MD 21287 8811, USA
    Int J Toxicol 24:443-9. 2005
    ..vestibular sensory epithelia of eight drug-treated animals were isolated for microscopic examination of vestibular hair cells and support cells...
  27. ncbi Decreased expression of calretinin and calbindin in the labyrinth of old gerbils
    Golda Anne Kevetter
    Department of Otolaryngology, University of Texas Medical Branch, Galveston, TX 77555 1063, USA
    Brain Res 957:362-5. 2002
    ..In six of seven pairs of animals, calretinin and calbindin staining was diminished or absent in the old animals. These changes suggest that a reduction in certain calcium-binding proteins may be a characteristic of aging animals...
  28. ncbi Quantitative analysis of stereociliary arrays on vestibular hair cells
    Michael H Rowe
    Neuroscience Program and Department of Biological Sciences, Ohio University, Athens, OH 45701, USA
    Hear Res 190:10-24. 2004
    ..Third, spacing between stereocilia changes with distance from the kinocilium. All three features will influence predictions of the tip link tensions that accompany bundle deflection...
  29. ncbi Electrophysiological properties of the utricular primary transducer are modified during development under hypergravity
    Christian Chabbert
    INSERM Unité 583, Physiopathologie et Therapie des deficits sensoriels et moteurs, Universite Montpellier II, Place Eugene Bataillon, 34095 Montpellier, France
    Eur J Neurosci 17:2497-500. 2003
    ..These results indicate that the electrophysiological properties of a primary transducer such as utricle may be modified by variation of the primary stimulus during development...
  30. ncbi Comparative morphology of rodent vestibular periphery. II. Cristae ampullares
    Sapan S Desai
    Department of Anatomy and Cell Biology, University of Illinois at Chicago, M C 512 808 S Wood St, Room 578, Chicago, IL 60612, USA
    J Neurophysiol 93:267-80. 2005
    ..Apart from this eminentia cruciatum, there are no statistical differences between horizontal and vertical cristae with regard to area, width, length, the number and type of hair cells, and number of calretinin-labeled calyx afferents...
  31. ncbi Recovery of hair cell function after damage induced by gentamicin in organ culture of rat vestibular maculae
    Akiko Taura
    Department of Otolaryngology Head and Neck Surgery, Kyoto University, Japan
    Brain Res 1098:33-48. 2006
    ..Therefore, this functional recovery of transduction activity was not owing to the proliferation of hair cells but was likely the self-repair of the hair bundle...
  32. pmc Effect of unilateral vestibular deafferentation on the initial human vestibulo-ocular reflex to surge translation
    Jun Ru Tian
    Department of Ophthalmology, University of California, Los Angeles, California 90095 7002, USA
    Exp Brain Res 176:575-87. 2007
    ..Chronic human UVD, on average, significantly impairs the surge LVOR for horizontally eccentric targets placed ipsilesionally, but this asymmetry is small relative to interindividual variation...
  33. ncbi Expression of GATA3 and tenascin in the avian vestibular maculae: normative patterns and changes during sensory regeneration
    Mark E Warchol
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 500:646-57. 2007
    ..These observations suggest that GATA3 expression may maintain positional information in the maculae during sensory regeneration...
  34. ncbi Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo
    Jonathan I Matsui
    Division of Biology and Biomedical Sciences, Washington University in St Louis, St Louis, Missouri 63110, USA
    J Neurosci 23:6111-22. 2003
    ..These findings suggest that inhibiting the activation of caspases promotes the survival of hair cells and protects against vestibular function deficits after aminoglycoside treatment...
  35. ncbi Functional and anatomic alterations in the gentamicin-damaged vestibular system in the guinea pig
    Markus L Y M Oei
    Department of Otorhinolaryngology, University Hospital Groningen, Groningen, The Netherlands
    Otol Neurotol 25:57-64. 2004
    ..The purpose of this study was to investigate the expected functional and morphologic effect of gentamicin on the vestibular system simultaneously by measurement of vestibular evoked potentials and electron microscopic evaluation...
  36. ncbi Morphometric analysis of the vestibular sensory epithelia of young adult rat
    R J Wubbels
    Vestibular Department, ENT, Academic Medical Center, University of Amsterdam, The Netherlands
    J Vestib Res 12:145-54. 2002
    ..Total cell density is 400-500 per 0.01 mm2, both in the otolith maculae and in the cristae ampullares. During the first year after maturation, no changes in epithelial morphology were observed and cell density remains constant...
  37. ncbi In vitro reconstitution of signal transmission from a hair cell to the growth cone of a chick vestibular ganglion cell
    M Hoshino
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550, Nagoya, Japan
    Neuroscience 120:993-1003. 2003
    ..This is the first demonstration of in vitro reconstitution of functional signal transmission from a hair cell to a vestibular ganglion cell...
  38. ncbi Voltage-gated outward K currents in frog saccular hair cells
    Luigi Catacuzzeno
    Dipartimento di Biologia Cellulare e Molecolare, Universita di Perugia, I 06123 Perugia, Italy
    J Neurophysiol 90:3688-701. 2003
    ..This thorough description of the IDRK and IA will contribute toward understanding the role of these currents in the electrical response on this preparation...
  39. ncbi Quantitative study of the vestibular sensory epithelium in cochleosaccular dysplasia
    Shin Kariya
    Department of Otolaryngology, University of Minnesota, Minneapolis, Minnesota, USA
    Otol Neurotol 26:495-9. 2005
    ..Cochleosaccular dysplasia is the most common pathologic finding seen in children with profound congenital sensorineural hearing loss. There has been no quantitative study on the peripheral vestibular system in cochleosaccular dysplasia...
  40. ncbi Differing effects on the inner ear of three gentamicin compounds: GM-C1, -C2 and -C1a
    Masamichi Kobayashi
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Acta Otolaryngol 123:916-22. 2003
    ..In this study we investigated differences in cochleo- and vestibulotoxicity between the three compounds..
  41. ncbi Robust generation of new hair cells in the mature mammalian inner ear by adenoviral expression of Hath1
    Jianyong Shou
    Department of Molecular Oncology, Genentech, Inc, South San Francisco, CA 94080, USA
    Mol Cell Neurosci 23:169-79. 2003
    ..Local adenoviral gene therapy in the inner ear may be a potential approach to treatment of hearing and balance disorders...
  42. ncbi Molecular characterization of two novel splice variants of G alphai2 in the rat vestibular periphery
    Joseph A Cioffi
    Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W Wisconsin Avenue, Milwaukee, WI 53226 3596, USA
    Brain Res Mol Brain Res 137:89-97. 2005
    ..These two novel alternatively spliced isoforms of Galphai2 putatively encode truncated proteins that could serve unique roles in the physiology of the vestibular neuroepithelium. Galphai2vest was found to be a processed pseudogene...
  43. ncbi The simultaneous in vivo perilymphatic perfusion of avian auditory and vestibular end organs
    Shunda R Irons-Brown
    Department of Physiology, University of Missouri Columbia, Columbia, MO 65203, USA
    J Neurosci Methods 131:57-64. 2003
    ..The model is well suited for use in the study of the pharmacology and toxicology of inner ear sensory systems...
  44. ncbi Spontaneous hair-cell renewal following gentamicin exposure in postnatal rat utricular explants
    Diana Berggren
    Department of Otolaryngology, Albert Einstein College of Medicine, New York, NY, USA
    Hear Res 180:114-25. 2003
    ....
  45. ncbi Circling behavior in the Ecl mouse is caused by lateral semicircular canal defects
    Kim Cryns
    Department of Medical Genetics, University of Antwerp, 2610 Antwerp, Belgium
    J Comp Neurol 468:587-95. 2004
    ..Investigation of the vestibuloocular reflex (VOR) in Ecl mice showed that their horizontal VOR on stimulation is virtually absent, which correlates with the morphological findings...
  46. ncbi Differential impact of hypergravity on maturating innervation in vestibular epithelia during rat development
    Sophie Gaboyard
    INSERM U432, Universite Montpellier II, Place E Bataillon, 34095 Montpellier, Cedex 05, France
    Brain Res Dev Brain Res 143:15-23. 2003
    ..Therefore, gravity appears to be an epigenetic factor influencing the late maturation of utricles. These differential effects of altered gravity on the development of the vestibular epithelium are discussed...
  47. ncbi Characterization of leukocyte subtypes in chicken inner ear sensory epithelia
    Elizabeth K O'Halloran
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195 7923, USA
    J Comp Neurol 475:340-60. 2004
    ..An absence of leukocytes in lesioned areas of the auditory sensory epithelium suggests they may not play a critical role in triggering hair cell regeneration...
  48. ncbi Morphology of physiologically identified otolith-related vestibular neurons in cats
    Hui Meng
    Department of Physiology, Tokyo Medical University, 6 1 1 Shinjuku, Shinjuku ku, Tokyo 160 8402, Japan
    Neurosci Lett 331:37-40. 2002
    ..Thus, it seems likely that the functional type of vestibular neurons cannot be presumed on the basis of their morphology alone...
  49. ncbi Gentamicin tympanoclysis: effects on the labyrinthine sensory cells
    Daniel J Pender
    Department of Otolaryngology, Columbia Presbyterian Medical Center, New York, NY, USA
    Laryngoscope 113:343-8. 2003
    ..The objective of the study was to determine whether a selective vestibular hair cell toxicity with sparing of the cochlear hair cells could be achieved by infusing different concentrations of gentamicin into the middle ears of adult cats...
  50. ncbi Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule
    Jonathan E Gale
    Department of Otolaryngology, HNS, University of Virginia School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurobiol 50:81-92. 2002
    ..The results indicate that sensory hair cells can undergo intracellular self-repair in the absence of mitosis, offering new possibilities for functional hair cell recovery and an explanation for non-proliferative recovery...
  51. ncbi Brief treatments with forskolin enhance s-phase entry in balance epithelia from the ears of rats
    M Montcouquiol
    Department of Otolaryngology-Head, Neck, University of Virginia, School of Medicine, Charlottesville, Virginia 22908, USA
    J Neurosci 21:974-82. 2001
    ..The results are consistent with the hypothesis that in mammalian vestibular epithelia elevated cAMP induces S-phase entry by increasing the number of growth factor receptors at the plasma membrane...
  52. ncbi Plasma membrane Ca2+-ATPase isoform 2a is the PMCA of hair bundles
    R A Dumont
    Department of Physiology, Johns Hopkins University, Baltimore, Maryland 21205, USA
    J Neurosci 21:5066-78. 2001
    ..This complete segregation of PMCA1 and PMCA2 isozymes holds for rat auditory and vestibular hair cells; PMCA2a is the only PMCA isoform in hair bundles of outer hair cells and vestibular hair cells and is the ..
  53. pmc Induction of cell proliferation in mammalian inner-ear sensory epithelia by transforming growth factor alpha and epidermal growth factor
    H Yamashita
    Virginia Merrill Bloedel Hearing Research Center, University of Washington, Seattle 98195, USA
    Proc Natl Acad Sci U S A 92:3152-5. 1995
    ..These observations suggest that stimulation of the EGF receptors by TGF-alpha binding, or EGF (plus insulin) binding, stimulates cell proliferation in the mature mammalian vestibular sensory epithelium...
  54. ncbi Head-tilting stabilometry in patients with benign paroxysmal positional vertigo
    Kenya Inukai
    Department of Otolaryngology, Niigata University, Faculty of Medicine, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Auris Nasus Larynx 35:31-5. 2008
    ..In this study, we examined changes in the parameters of stabilometry under an upright condition and head-tilt conditions in patients with BPPV...
  55. ncbi M-like K+ currents in type I hair cells and calyx afferent endings of the developing rat utricle
    Karen M Hurley
    The Bobby R Alford Department of Otorhinolaryngology, Head and Neck Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
    J Neurosci 26:10253-69. 2006
    Type I vestibular hair cells have large K+ currents that, like neuronal M currents, activate negative to resting potential and are modulatable. In rodents, these currents are acquired postnatally...
  56. pmc Kvbeta1.1 associates with Kvalpha1.4 in Chinese hamster ovary cells and pigeon type II vestibular hair cells and enhances the amplitude, inactivation and negatively shifts the steady-state inactivation range
    M J Correia
    Department of Otolaryngology, Room 7 102 Blocker Medical Research Building Route 1063, UTMB, Galveston, TX 77555 1063, USA
    Neuroscience 152:809-20. 2008
    ..4 and Kvbeta1.1 to suggest N-and C-type inactivation, co-assembly and association of Kvalpha1.4 and Kvbeta1.1 may also produce changes in the time dependent inactivation properties of vestibular hair cells.
  57. ncbi Architecture of the mouse utricle: macular organization and hair bundle heights
    A Li
    Department of Biological Sciences and Neuroscience Program, Ohio University, Athens, OH 45701, USA
    J Neurophysiol 99:718-33. 2008
    Hair bundles are critical to mechanotransduction by vestibular hair cells, but quantitative data are lacking on vestibular bundles in mice or other mammals...
  58. ncbi The combined effects of trkB and trkC mutations on the innervation of the inner ear
    B Fritzsch
    Creighton University, Department of Biomedical Sciences, Omaha, NE 68178, USA
    Int J Dev Neurosci 16:493-505. 1998
    ....
  59. ncbi A place principle for vertigo
    Richard R Gacek
    Department of Otolaryngology, Head and Neck Surgery, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Auris Nasus Larynx 35:1-10. 2008
    ..To provide a road map of the vestibular labyrinth and its innervation leading to a place principle for different forms of vertigo...
  60. ncbi Morphometric investigations of sensory vestibular structures in tadpoles (Xenopus laevis) after a spaceflight: implications for microgravity-induced alterations of the vestibuloocular reflex
    E Horn
    Gravitationsphysiologie, Abteilung Neurobiologie, Universitat Ulm, Ulm, Federal Republic of Germany
    Protoplasma 229:193-203. 2006
    ..CalBindin is common in mature sensory cells including vestibular hair cells and is probably involved in otoconia formation...
  61. ncbi Immunoreactivity for myeloperoxidase (MPO) in the vestibule after the injection of bacterial lipopolysaccharide into the middle ear
    Ken ichi Watanabe
    Department of Oto Rhino Laryngology, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Auris Nasus Larynx 29:241-5. 2002
    ..In this study, the effect of endotoxin on the vestibule of the ear of guinea pigs was immunohistochemically examined...
  62. ncbi Blockade of c-Jun N-terminal kinase pathway attenuates gentamicin-induced cochlear and vestibular hair cell death
    Jukka Ylikoski
    Institute of Biotechnology, University of Helsinki, Finland
    Hear Res 166:33-43. 2002
    ..Thus, our results imply that activation of JNK cascade may be a common molecular outcome of cellular stress in the inner ear sensory epithelia and that attenuation of the lesion can be provided by inhibiting JNK activation...
  63. ncbi Ultrastructural evaluation of calcitonin gene-related peptide immunoreactivity in the human cochlea and vestibular endorgans
    Wie Jia Kong
    Department of Otolaryngology, University of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria
    Eur J Neurosci 15:487-97. 2002
    ..CGRP immunoreactivity appeared to be confined to efferent systems in all cases. This study presents evidence that CGRP could serve a role in neurotransmission or neuroregulation in both cochlear and vestibular efferent systems of human...
  64. ncbi Subcellular immunolocalization of NMDA receptor subunit NR1, 2A, 2B in the rat vestibular periphery
    Gail Ishiyama
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Brain Res 935:16-23. 2002
    ..The afferent calyceal terminals and nerve fibers innervating type I vestibular hair cells were strongly NR1, NR2A, and NR2B immunoreactive...
  65. ncbi Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2
    Deron R Herr
    Department of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, La Jolla, California 92037, USA
    J Neurosci 27:1474-8. 2007
    ..This study reveals the previously unknown role of S1P signaling in the maintenance of cochlear and vestibular integrity and suggests a means for therapeutic intervention in degenerative hearing loss...
  66. ncbi Mechanoelectrical and voltage-gated ion channels in mammalian vestibular hair cells
    Ruth Anne Eatock
    The Bobby R Alford Department of Otorhinolaryngology and Communicative Sciences, Baylor College of Medicine, Houston, Tex 77005, USA
    Audiol Neurootol 7:31-5. 2002
    ..This problem may be overcome by factors that inhibit g(K,L)'s activation at resting potential. Also, the calyx may support nonquantal transmission...
  67. pmc An adenylyl cyclase signaling pathway predicts direct dopaminergic input to vestibular hair cells
    M J Drescher
    Laboratory of Bio Otology, Department of Otolaryngology, Wayne State University School of Medicine, Lande Medical Research Building, 540 East Canfield Avenue, Detroit, MI 48201, USA
    Neuroscience 171:1054-74. 2010
    ..co-localizes with AC5/6, with a marked presence of all three proteins in subcuticular regions of type I vestibular hair cells. A putative efferent, presynaptic source of dopamine was identified in tyrosine hydroxylase-positive nerve ..
  68. ncbi Low density of membrane particles in auditory hair cells of lizards and birds suggests an absence of somatic motility
    Christine Köppl
    Lehrstuhl für Zoologie, Technische Universitat Munchen, 85747 Garching, Germany
    J Comp Neurol 479:149-55. 2004
    ..This suggests that nonmammalian hair cells do not possess high densities of motor protein in their membranes and are thus unlikely to be capable of somatic motility...
  69. ncbi A pharmacologically distinct nicotinic ACh receptor is found in a subset of frog semicircular canal hair cells
    Joseph C Holt
    Department of Pharmacology SL83, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    J Neurophysiol 90:1526-36. 2003
    ..of afferent discharge which are thought to be mediated by at least two distinct ACh receptors present on vestibular hair cells, i.e., alpha9-containing nicotinic receptors (alpha9nAChR) and muscarinic receptors (mAChR), respectively...
  70. ncbi Course and targets of the calbindin D-28k subpopulation of primary vestibular afferents
    J Bäurle
    Freie Universitat Berlin, Fachbereich Humanmedizin, Universitatsklinikum Benjamin Franklin, Department of Physiology, Germany
    J Comp Neurol 402:111-28. 1998
    ..that innervate the central regions of the vestibular end organs exclusively via calyx endings on type I vestibular hair cells. These large-diameter PVA are characterized by irregular spontaneous discharge patterns and predominantly ..
  71. pmc Spontaneous hair cell regeneration in the mouse utricle following gentamicin ototoxicity
    Kohei Kawamoto
    Department of Otolaryngology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi, Osaka 570 8506, Japan
    Hear Res 247:17-26. 2009
    ..The extent of regeneration in vestibular hair cells has been characterized for several mammalian species including guinea pig, rat, and chinchilla, but not ..
  72. pmc Sensory transduction and adaptation in inner and outer hair cells of the mouse auditory system
    Eric A Stauffer
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908 1392, USA
    J Neurophysiol 98:3360-9. 2007
    ..of the slow component in both inner and outer hair cells was similar to the rate of slow adaptation in vestibular hair cells. The rate of the fast component was similar to that of auditory hair cells in other organisms and several ..
  73. ncbi [High-frequency rotation sensation function damage of the crista of the horizontal semicircular canal induced by gentamicin and its morphological basis.]
    Liang Chen
    Department of Otorhinolaryngology, EENT Hospital of Fudan University, Shanghai 200031, China
    Sheng Li Xue Bao 61:559-66. 2009
    ..In group 3, vestibular hair cells were entirely impaired or necrosis...
  74. pmc Sox2 and JAGGED1 expression in normal and drug-damaged adult mouse inner ear
    Elizabeth C Oesterle
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, CHDD CD176, Box 357923, Seattle, WA 98195 7923, USA
    J Assoc Res Otolaryngol 9:65-89. 2008
    ..Sox2 is absent from auditory hair cells, but is expressed in a subset of vestibular hair cells. Double-labeling experiments with Sox2 and calbindin suggest Sox2-positive hair cells are Type II...
  75. ncbi Development of calretinin immunoreactivity in the mouse inner ear
    C J Dechesne
    Laboratoire de Neurophysiologie Sensorielle, Unité INSERM 254, Montpellier, France
    J Comp Neurol 346:517-29. 1994
    ..The earliest immunoreactivity was found at E17 in vestibular hair cells (VHCs), then, at E19, in afferent fibers entering the sensory epithelia and in rare ganglion neurons...
  76. ncbi [Ototoxic effects of streptomycin in vestibular organotypic cultures]
    Dong Zhen Yu
    Department of Otorhinolaryngology, Affiliated Sixth People s Hospital, Shanghai Jiaotong University, Otorhinolaryngology Institute of Shanghai Jiaotong University, Shanghai 200233, China
    Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 44:53-6. 2009
    ..To investigate the ototoxic effects of streptomycin in vestibular organotypic cultures...
  77. ncbi Inhibition of caspases prevents ototoxic and ongoing hair cell death
    Jonathan I Matsui
    Central Institute for the Deaf, Fay and Carl Simons Center for Biology of Hearing and Deafness, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 22:1218-27. 2002
    ..Here we identify several important signaling events that regulate the death of vestibular hair cells. Chick utricles were cultured in media supplemented with the ototoxic antibiotic neomycin and selected ..
  78. pmc The aminoglycoside antibiotic dihydrostreptomycin rapidly enters mouse outer hair cells through the mechano-electrical transducer channels
    Walter Marcotti
    School of Life Sciences, University of Sussex, Falmer, Brighton BN1 9QG, UK
    J Physiol 567:505-21. 2005
    ..of the widely used aminoglycoside antibiotics is irreversible intracellular damage to the auditory and vestibular hair cells of the inner ear. The mechanism of entry into the hair cells has not been unequivocally resolved...
  79. ncbi Evolutionary changes in the cochlea and labyrinth: Solving the problem of sound transmission to the balance organs of the inner ear
    John Carey
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:482-9. 2006
    ..the evolutionary adaptations in the vertebrate inner ear that allow selective activation of auditory or vestibular hair cells, although both are housed in the same bony capsule...
  80. pmc Resting discharge patterns of macular primary afferents in otoconia-deficient mice
    T A Jones
    Communication Sciences and Disorders, School of Allied Health Sciences, East Carolina University, Health Sciences Building, Rm 3310P, Greenville, NC 27858 4353, USA
    J Assoc Res Otolaryngol 9:490-505. 2008
    ..states that such discharge patterns are independent of stimulation and depend instead on excitation by vestibular hair cells due to background release of synaptic neurotransmitter...
  81. ncbi Vestibular system in infants after systemic aminoglycoside therapy
    Olaf Zagolski
    Diagnostic and Therapeutic Medical Centre Medicina, Krakow, Poland
    Int J Pediatr Otorhinolaryngol 71:1797-802. 2007
    ..The mitochondria-mediated pathway of apoptosis may play a role in inducing the apoptosis of vestibular hair cells due to aminoglycoside toxicity...
  82. pmc Topological and developmental gradients of calbindin expression in the chick's inner ear
    Hakim Hiel
    Center for Hearing and Balance, Department of Otolaryngology, Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    J Assoc Res Otolaryngol 3:1-15. 2002
    ..endings onto Type I vestibu lar hair cells were strongly labeled by the calbindin antibody, while vestibular hair cells were negative for calbindin immunoreactivity...
  83. ncbi Expression of canonical transient receptor potential channel (TRPC) 1-7 in the mouse inner ear
    Masaya Takumida
    Department of Otolaryngology, Hiroshima University Faculty of Medicine, Hiroshima, Japan
    Acta Otolaryngol 129:1351-8. 2009
    ..It is suggested that TRPCs play a functional role in the sensory cell transduction system in the inner ear...
  84. ncbi Auditory and vestibular defects and behavioral alterations after neonatal administration of streptomycin to Lewis rats: Similarities and differences to the circling (ci2/ci2) Lewis rat mutant
    Marko Schirmer
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, Bunteweg 17, Hannover, Germany
    Brain Res 1155:179-95. 2007
    ..neonatal LEW rats over 3 weeks by streptomycin, which induced bilateral degeneration of cochlear and vestibular hair cells. Following this treatment period, the behavioral syndrome of the streptomycin-treated animals, including ..
  85. pmc Ionic composition of endolymph and perilymph in the inner ear of the oyster toadfish, Opsanus tau
    Tamer A Ghanem
    Department of Bioengineering, University of Utah, Salt Lake City, Utah 84112, USA
    Biol Bull 214:83-90. 2008
    ..of Ca2+ and Na+ in the endolymph may have significant implications for the physiological function of the mechanoelectrical transduction channels in the vestibular hair cells of fish compared to those of their mammalian counterparts.
  86. ncbi The muscarinic inhibition of the potassium M-current modulates the action-potential discharge in the vestibular primary-afferent neurons of the rat
    C Perez
    Instituto de Fisiologia, Universidad Autonoma de Puebla, Puebla, Mexico
    Neuroscience 158:1662-74. 2009
    There is consensus that muscarinic and nicotinic receptors expressed in vestibular hair cells and afferent neurons are involved in the efferent modulation of the electrical activity of the afferent neurons...
  87. ncbi Hair cells in the inner ear of the pirouette and shaker 2 mutant mice
    L A Beyer
    The Department of Otolaryngology, Kresge Hearing Research Institute, School of Medicine, The University of Michigan, USA
    J Neurocytol 29:227-40. 2000
    ..designed to characterize a pathological actin bundle that is found in both the inner hair cells and the vestibular hair cells in all five vestibular organs in these two mutants...
  88. ncbi Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear
    Michael R Deans
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 27:3139-47. 2007
    b>Vestibular hair cells have a distinct planar cell polarity (PCP) manifest in the morphology of their stereocilia bundles and the asymmetric localization of their kinocilia...
  89. ncbi Lysosomal augmentation during aminoglycoside uptake in cochlear hair cells
    E Hashino
    Center for Hearing and Deafness, State University of New York at Buffalo, 14214, USA
    Brain Res 887:90-7. 2000
    ..such as kanamycin, have ototoxic side effects, which often result in degeneration of cochlear and vestibular hair cells in the inner ear...
  90. ncbi Potassium depolarization of mammalian vestibular sensory cells increases [Ca2+]i through voltage-sensitive calcium channels
    C Boyer
    INSERM U 432, Neurobiologie et Développement du Système Vestibulaire, Universite Montpellier II, France
    Eur J Neurosci 10:971-5. 1998
    The existence of voltage-sensitive Ca2+ channels in type I vestibular hair cells of mammals has not been conclusively proven...
  91. ncbi Distribution of frequenin in the mouse inner ear during development, comparison with other calcium-binding proteins and synaptophysin
    C Sage
    INSERM U 432, Universite de Montpellier II, Montpellier, France
    Hear Res 150:70-82. 2000
    ..Frequenin was not found in vestibular hair cells and in cochlear inner and outer hair cells...
  92. pmc Otoconin-90 deletion leads to imbalance but normal hearing: a comparison with other otoconia mutants
    X Zhao
    Genetics Department, Boys Town National Research Hospital, 555 North 30th Street, Omaha, NE 68131, USA
    Neuroscience 153:289-99. 2008
    Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ)...
  93. pmc Targeted knockout and lacZ reporter expression of the mouse Tmhs deafness gene and characterization of the hscy-2J mutation
    Chantal M Longo-Guess
    The Jackson Laboratory, Bar Harbor, ME 04609, USA
    Mamm Genome 18:646-56. 2007
    ..activity in Tmhs ( tm1Kjn ) heterozygous mice indicates that Tmhs is highly expressed in the cochlear and vestibular hair cells of the inner ear. Expression is first detectable at E15...
  94. ncbi Cells resembling hair cells in developing rat olfactory and nasal respiratory epithelia
    B P Menco
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208 3520, USA
    Tissue Cell 29:707-13. 1997
    ..The apex of the cell resembles the apices of vestibular hair cells. The cell has a cone-shaped bundle of microvilli, resembling the complex bundle of hair-cell stereocilia, ..
  95. ncbi Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear
    L M Bianchi
    Department of Otolaryngology and Communicative Sciences, Medical University of South Carolina, Charleston 29425, USA
    Anat Rec 254:127-34. 1999
    ..The receptor EphA4 was detected in vestibular hair cells. EphA5 and EphA7 were detected mainly in cochlear and vestibular supporting cells...
  96. pmc Osteopontin is not critical for otoconia formation or balance function
    Xing Zhao
    Genetics Department, Boys Town National Research Hospital, Omaha, NE 68131, USA
    J Assoc Res Otolaryngol 9:191-201. 2008
    ..Despite the presence of the protein in wild-type otoconia and vestibular hair cells, morphological, ultrastructural, and protein and calcium composition analyses of osteopontin null otoconia ..
  97. ncbi Canalicular reticulum in vestibular hair cells
    C D Cunningham
    Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina, Walton Research Building, Room 608, 39 Sabin Street, P O Box 250150, Charleston, SC 29425, USA
    Hear Res 143:69-83. 2000
    ..Similarities between cochlear and vestibular hair cells prompted investigation of the presence of CR in hair cells of the gerbil vestibular labyrinth...
  98. ncbi Are there efferent synapses in fish taste buds?
    Klaus Reutter
    Department of Anatomy, University of Tubingen, Germany
    J Neurocytol 33:647-56. 2004
    ..This structure is regarded as a prerequisite of a typical efferent synapse, as occurring in cochlear and vestibular hair cells. In fish taste buds, efferent synapses are rare and were found only in a few species that belong to ..
  99. pmc Hes5 expression in the postnatal and adult mouse inner ear and the drug-damaged cochlea
    Byron H Hartman
    Department of Biological Structure, University of Washington, Seattle, WA 98195, USA
    J Assoc Res Otolaryngol 10:321-40. 2009
    ..in the cochlea during embryonic development, and loss of Hes5 leads to overproduction of auditory and vestibular hair cells. However, due to technical limitations and inconsistency between previous reports, the precise spatial and ..
  100. pmc The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
    Johanna Mantela
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Development 132:2377-88. 2005
    Precursors of cochlear and vestibular hair cells of the inner ear exit the cell cycle at midgestation. Hair cells are mitotically quiescent during late-embryonic differentiation stages and postnatally...
  101. ncbi [Properties of cholinergic receptor-mediated ion channels on type I vestibular hair cells of guinea pigs]
    Yun Zhu
    Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Sheng Li Xue Bao 60:375-81. 2008
    To confirm the existence of cholinergic receptors on type I vestibular hair cells (VHCs I) of guinea pigs and to study the properties of the cholinergic receptor-mediated ion channels on VHCs I, electrophysiological responses of isolated ..

Research Grants63

  1. HAIR CELL REGENERATION IN THE VESTIBULAR OTOLITH ORGANS
    Richard Baird; Fiscal Year: 2001
    ..shed light on the intercellular and intracellular mechanisms that initiate and regulate hair cell regeneration and, ultimately, suggest new means to stimulate the regeneration of auditory and vestibular hair cells in higher vertebrates.
  2. MECHANOELECTRICAL TRANSDUCTION IN ADULT OUTER HAIR CELLS
    David He; Fiscal Year: 2004
    ..in the basolateral membrane, Although the mechanoelectrical transduction in low-vertebrate and mammalian vestibular hair cells has been well studied, the forward transduction process in adult cochlear hair ceils has essentially not ..
  3. Development of Cholinergic Synapses in the Inner Ear
    DWAYNE SIMMONS; Fiscal Year: 2009
    ..We will also investigate the formation of nAChRs in vestibular hair cells. Specific aim 2 investigates the hypothesis that the differentiation of postsynaptic nicotinic receptors ..
  4. IDENTIFICATION OF ACOUSTICO-LATERALIS TRANSMITTERS
    Dennis G Drescher; Fiscal Year: 2013
    ..as an efferent transmitter within the auditory organ of Corti and as a receptoneural transmitter in vestibular hair cells. We will investigate norepinephrine-containing adrenergic efferents constituting a newly-recognized neural ..
  5. Structure-function analyses on novel processes of type II vestibular hair cells
    Jennifer S Stone; Fiscal Year: 2013
    ..A major cause of balance disorders is the loss of vestibular hair cells in the inner ear, which convert head movements into electrical signals that are sent to the brain via the ..
  6. Functional characterization of the Bronx waltzer deafness gene
    Botond Banfi; Fiscal Year: 2013
    ..Histological analysis of bv mice revealed a selective loss of cochlear inner hair cells and vestibular hair cells during the perinatal period, without accompanying damage to outer hair cells...
  7. Core Center for BioBehavioral Sciences of Communication Disorders
    Mabel L Rice; Fiscal Year: 2013
    ..of later cognitive and language development, clinical trials with a viral vector to induce regeneration of vestibular hair cells for the treatment of tinnitus/balance disorders, and gene regulation of axon growth related to cortical ..
  8. Identifying the Atoh1 targetome in hair cells with deep sequencing
    Andrew K Groves; Fiscal Year: 2013
    ..For these reasons, Atoh1 has been proposed as tool for gene therapy to replace lost auditory or vestibular hair cells. Despite the great interest in Atoh1's function in development and its potential use in regenerative ..
  9. Ion Channel Function in Auditory &Vestibular Hair Cells
    Jeffrey R Holt; Fiscal Year: 2013
    ..We expect that this project will produce information that will form the basis for development of future strategies to treat deafness and balance problems in some of the ~28 million Americans who suffer from inner ear disorders. ..
  10. Autosomal dominant hearing loss
    Karen Friderici; Fiscal Year: 2009
    ..using in situ localization of the protein and transient expression of the gamma-actin in cochlear and vestibular hair cells. Animal models with the mutations will be created and characterized...
  11. Synaptic Processing in the Vestibular System
    Ruth Anne Eatock; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Vestibular hair cells transduce head position and motion into electrochemical signals which they transmit across synapses to afferent nerve fibers...
  12. CELLULAR MECHANISMS OF THE VESTIBULAR SYSTEM
    Anna Lysakowski; Fiscal Year: 2013
    ..The hypothesis is that neurotransmitter release from type I hair in low- frequency vestibular hair cells may differ from high-frequency auditory and vibratory organs...
  13. Replacement of vestibular hair cells in normal and damaged adult mice
    STEPHANIE ANN FURRER; Fiscal Year: 2013
    ....
  14. TMC gene function in sensory hair cells
    Jeffrey R Holt; Fiscal Year: 2013
    ..2003). Tmc1 and closely related Tmc2 are expressed in auditory and vestibular hair cells of the mouse inner ear...
  15. Molecular Genetics of Usher Syndrome IIIA
    Kumar N Alagramam; Fiscal Year: 2013
    ..Preliminary work shows that Clrn1 mRNA was expressed as early as embryonic day 16.5 in the auditory and vestibular hair cells and associated ganglionic neurons...
  16. Global analysis of bundle protein transport in mouse vestibular hair cells
    Jocelyn F Krey; Fiscal Year: 2013
    ..the hair bundle, a group of actin-filled stereocilia that project from the apical surface of auditory and vestibular hair cells. The study of deafness-linked genes has led to the identification of a number of proteins that are ..
  17. Role of myosin 1c in adaptation in the inner ear
    Lynne M Coluccio; Fiscal Year: 2012
    ..The prevailing model for mechanotransduction, thought to be well-conserved for both cochlear and vestibular hair cells, is one in which neighboring stereocilia connected by extracellular filaments called tip links, deflect in ..
  18. Planar Polarity Mechanisms in Mammalian Inner Ear Development
    Michael R Deans; Fiscal Year: 2013
    ..result, in order to respond to the broadest range of motions the utricle and saccule contain thousands of vestibular hair cells arranged in radiating arrays spanning a range of nearly 360ps of stereocilia bundle orientations...
  19. Development of atonal therapy for bilateral vestibular hypofunction
    Hinrich Staecker; Fiscal Year: 2011
    ..Although there are a diverse series of underlying etiologies for balance disorders, loss of vestibular hair cells represents a common cause of balance dysfunction...
  20. Targeting S1P receptors to prevent hearing loss
    Jerold Chun; Fiscal Year: 2010
    ..the receptor known as S1P2 in a knockout mouse model results in progressive degeneration of cochlear and vestibular hair cells, balance defects, and profound deafness...
  21. REGENERATION AND REINNERVATION OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 1999
    ..of vestibular supporting cells (putative hair cell progenitors - Specific Aim 1 (SA1)) or regenerating vestibular hair cells (SA2) or about changes, if any, in the action potential discharge of primary afferents as afferent and ..
  22. HUMAN MODEL OF VESTIBULAR DEAFFERENTATION
    Akira Ishiyama; Fiscal Year: 2001
    ..on the vestibular nerve for survival? 2) Reciprocally, is the vestibular nerve dependent on the vestibular hair cells for survival? 3) Does retrograde degeneration occur in the presence of intact afferent dendrites? 4) Is ..
  23. HAIR CELL REGENERATION--INTERCELLULAR REGULATION
    Jennifer Stone; Fiscal Year: 2002
    ..Thus, loss of hair cells leads to profound sensory deficits. In contrast, avian species produce vestibular hair cells continually throughout their life time, and they regenerate auditory and vestibular hair cells in response ..
  24. DEVELOPMENT OF THE XENOPUS ACOUSTICO-VESTIBULAR SYSTEM
    ELBA SERRANO; Fiscal Year: 2002
    ..Experiments will focus on the auditory and vestibular hair cells of the amphibian, Xenopus laevis...
  25. DIVERSITY IN MEMBRANE PROPERTIES OF INNER EAR HAIR CELLS
    ELBA SERRANO; Fiscal Year: 1993
    ..is intended to advance that understanding by providing insight into differences between auditory and vestibular hair cells related to their specialized function in sensing stimulus modalities of different origin and frequency...
  26. Role of P53 in Aminoglycoside Ototoxicity
    Mei Zhang; Fiscal Year: 2009
    ..Moreover, our data showed that PFT significantly protects the cochlear hair cells but not the vestibular hair cells against low dose gentamicin...
  27. Vestibular Recovery after Intratympanic Gentamicin
    John Carey; Fiscal Year: 2004
    ..1999). The first goal of this project is to determine if the afferent processes contacting vestibular hair cells and the synaptic specializations of these hair cells are preserved after intratympanic gentamicin ..
  28. HISTAMINE STORAGE AND RELEASE--ROLE OF SYNAPTIC BODY
    Paul Guth; Fiscal Year: 1992
    ..that reserpine and other amine-depleting drugs cause a loss of electron-opacity in the synaptic bodies of vestibular hair cells. According to most authorities neither catecholamines nor indolamines are involved in hair cell recepto-..
  29. PHARMACOLOGY OF THE TYPE I HAIR CELL/CALYX SYNAPSE
    KATHERINE RENNIE; Fiscal Year: 2002
    ..Experiments described in this proposal will address the hypothesis that the membrane properties of type I Vestibular hair cells can be modulated and that one source of this modulation is through transmitter release from the apical ..
  30. Function of the Vestibular System Following Regeneration
    J Dickman; Fiscal Year: 2005
    Over the past decade it has been well established that lost vestibular hair cells regenerate and are re-innervated...
  31. Restoration of vestibular hair cells induced by AdMath1
    Douglas Brough; Fiscal Year: 2005
    Loss of vestibular hair cells can occur due to a variety of disorders and results in dysfunction of the vestibulo-occular reflex and loss of balance...
  32. Role of myosin 1c in adaptation in the inner ear
    LYNNE COLUCCIO; Fiscal Year: 2007
    ..The prevailing model for mechanotransduction, thought to be well-conserved for both cochlear and vestibular hair cells, is one in which neighboring stereocilia connected by extracellular filaments called tip links, deflect in ..
  33. Hair cell development in the mouse embryo
    GWENAELLE GELEOC; Fiscal Year: 2006
    ..The first aim is to characterize the prenatal acquisition of voltage sensitive conductances in vestibular hair cells. The second aim is to characterize the acquisition of mechanotransduction and adaptation in developing ..
  34. ROLE OF THE PLASMA MEMBRANE CALCIUM PUMP IN HEARING
    JOHN PENNISTON; Fiscal Year: 2002
    ..1) to determine which PMCA ioforms and alternative splice variants are expressed in rodent cochlea and vestibular hair cells; (2) to determine the functional properties of the major "deafwaddler" and "wriggle" PMCA mutants and of ..
  35. Chemoanatomic bases for peripheral vestibular function
    GAY HOLSTEIN; Fiscal Year: 2007
    ..The proposed research is unique, and will have direct bearing on the development of more effective therapeutic interventions, both medicinal and device-oriented, for peripheral vestibular disorders. [unreadable] [unreadable] [unreadable]..
  36. MORPHOLOGIC BASIS FOR CENTRAL VESTIBULAR INHIBITION
    GAY HOLSTEIN; Fiscal Year: 2002
    ....
  37. QUANTITATIVE MORPHOPHYSIOLOGY OF VESTIBULAR AFFERENTS
    GOLDA KEVETTER; Fiscal Year: 2004
    ..This could prove important for treatment of patients with vestibular disorders, such as those suffering with Meniere's disease or even normal aging. ..
  38. EFFERENT INNERVATION OF IDENTIFIED VESTIBULAR AFFERENTS
    Anna Lysakowski; Fiscal Year: 2008
    ..The intent is to produce a body of morphological, neurochemical and cell biological knowledge from which physiologically and pharmacologically testable hypotheses can be derived. [unreadable] [unreadable] [unreadable]..
  39. Genetic Analysis of Usher Syndrome in Zebrafish
    JONATHAN MATSUI; Fiscal Year: 2005
    ..Both morphological and physiological studies (e.g. ERG and auditory brain stem responses) will be used. Positional cloning strategies will be used to identify the genes responsible for these mutations. ..
  40. Vestibular Pathology in Meniere's Disease
    Akira Ishiyama; Fiscal Year: 2007
    ..or with alterations in neuronal number or size? 6) What are the morphometric correlates to abnormalities on traditional vestibular testing: caloric paresis, and decreased gain and time constant on step rotational testing? ..
  41. CELLULAR AND MOLECULAR STUDIES OF VESTIBULAR HAIR CELLS
    MANNING CORREIA; Fiscal Year: 2007
    ..1. This channel is found in the majority of native avion vestibular hair cells. The effects of the chimera insertion will be assayed by making single channel recordings from the mutated ..
  42. Ion Channel Function in Auditory & Vestibular hair cells
    Jeffrey Holt; Fiscal Year: 2008
    ..Because deficiencies with these critical functions cause deafness and balance disorders, the information gained through these studies will facilitate design of rational strategies to treat genetic inner disorders. ..
  43. Neurotransmission at the vestibular calyx synapse
    KATHERINE RENNIE; Fiscal Year: 2007
    ..The combination of experimental & modeling approaches will elucidate how sensory information is transformed by HC1 & converted into a neural code by their afferents. ..
  44. DETERMINANTS OF NEURONAL CONNECTIVITY IN THE COCHLEA
    DONNA WHITLON; Fiscal Year: 2005
    ..But in addition, the results will be relevant to questions of neural regeneration and bear on experimental attempts to encourage re-establishment of functional nerve fiber networks in the cochlea after nerve damage. ..
  45. VOR adaptation/utility of saccades as rehab strategies
    Michael Schubert; Fiscal Year: 2008
    ..This is important for the long-term goals of this project, which are to determine the adaptive preferences that individuals with vestibular loss use to improve gaze stability. ..
  46. NMDA Receptors and Ethanol Withdrawal Seizures
    Adam Hendricson; Fiscal Year: 2005
    ....
  47. VESTIBULAR EFFECTS OF INTRATYMPANIC GENTAMICIN
    John Carey; Fiscal Year: 2005
    ..Johns Hopkins is uniquely suited to this training because it has a core group devoted to vestibular research, and the mentor's laboratory has successfully used all of the techniques required. ..
  48. Dynamic Molecular Mechanisms of Neurotransmitter Release
    FELIX SCHWEIZER; Fiscal Year: 2004
    ..By revealing novel mechanisms for the modulation of neurotransmitter release they may identify targets for therapeutic intervention in neurological diseases. ..
  49. In Vitro Analysis of Embryonic Inner Ear Cells
    LYNNE BIANCHI; Fiscal Year: 2002
    ..characterize the aggregation of inner ear cells in vitro by testing the hypotheses that both cochlear and vestibular hair cells reaggregate and that this reaggregation is limited to early stages of development...
  50. The Mouse as a Tool for Ear Research
    Kenneth Johnson; Fiscal Year: 2003
    ..abstract_text> ..
  51. MECHANISMS OF SENSORY HAIR CELL DEATH
    LISA CUNNINGHAM; Fiscal Year: 2003
    ..abstract_text> ..
  52. The Mouse as an Instrument for Ear Research II
    Kenneth Johnson; Fiscal Year: 2005
    ..Ultimately, this meeting will bring students and established investigators, with varying expertise and experience, together to discuss their research findings, identify areas of common research interest and develop future directions. ..
  53. Vestibular Hair Cell Regeneration
    LARRY HOFFMAN; Fiscal Year: 2007
    ..more than a decade of research, the control of the anatomical and functional regeneration capacity of vestibular hair cells in mammals remains unresolved...
  54. Micro-Electric Impedance Spectroscopy of Hair Cells
    Richard Rabbitt; Fiscal Year: 2009
    ..muEl signatures of both auditory and vestibular hair cells are being studied in response to adequate stimuli in control conditions and following application of ..
  55. Afferent Innervation of the Postnatal Cochlea
    CLIFFORD HUME; Fiscal Year: 2008
    ..Finally, I will use molecular techniques to begin to dissect the signals that regulate axon guidance in the developing auditory system. ..
  56. Molecular mechanisms of vestibular hair cell exocytosis
    FELIX SCHWEIZER; Fiscal Year: 2009
    ..The aim of this application is to elucidate the molecular mechanisms underlying synaptic transmission from vestibular hair cells to afferent fibers...
  57. Adenylyl Cyclase Signaling in Ear Sensory Eipthelia
    MARIAN DRESCHER; Fiscal Year: 2009
    ..The elucidation of these AC-mediated signal transduction pathways in inner ear sensory epithelia may allow eventual pharmacological amelioration of tinnitus, sensorinetiral deafness and vertigo. ..
  58. FGF in sensory system development
    OLIVIA MARY BERMINGHAM MCDONOGH; Fiscal Year: 2010
    ..Moreover, a better understanding of the molecular pathways regulating normal development will be critical for rational strategies for hair cell replacement and regeneration in adult onset deafness. ..
  59. Mechanisms of Sensory Hair Cell Death and Survival
    Lisa L Cunningham; Fiscal Year: 2010
    ..Understanding these mechanisms will guide the development of therapies aimed at preventing hearing loss caused by ototoxic drugs. ..
  60. Transcriptome and Proteome Analysis of Mouse Inner Ears
    Qing Zheng; Fiscal Year: 2007
    ..Genes, proteins and their molecular pathways identified in this proposed research are potential targets of drug therapies for hearing loss that affects more than 28 million Americans. ..
  61. Evalution of Vestibular Function in Meniere's Disease
    John Carey; Fiscal Year: 2009
    ..Comparisons of angular and translational VOR deficits after intratympanic gentamicin should demonstrate whether or not the utricle is less susceptible than the semicircular canals to intratympanic gentamicin. ..
  62. Genome-wide location analysis of neuronal genes
    Michael Rosenfeld; Fiscal Year: 2007
    ..We believe that with validation of these approaches, technologies developed here will be of widespread utility in neuroscience, particularly in studies of development and neurodegenerative disease. ..
  63. GENETICS OF A NEW MOUSE MODEL FOR DEAFNESS
    Qing Zheng; Fiscal Year: 2002
    ..Aim 2. Construct a physical contig of YACS and BACS clones across the minimal genetic region. Aim 3. Fully characterize the development and pathology of inner ears from hml/hml mice compared with hml/+ and +/+ controls. ..