afferent neurons

Summary

Summary: Neurons which convey sensory information centrally from the periphery.

Top Publications

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  2. ncbi Molecular mechanisms of nociception
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
    Nature 413:203-10. 2001
  3. ncbi A TRP channel that senses cold stimuli and menthol
    Andrea M Peier
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Cell 108:705-15. 2002
  4. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
  5. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
  6. ncbi Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    David D McKemy
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 416:52-8. 2002
  7. ncbi Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    Mark J Zylka
    Division of Biology, 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 45:17-25. 2005
  8. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
  9. ncbi Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 TD, United Kingdom
    J Neurosci 21:8722-33. 2001
  10. ncbi Characterization of mu opioid receptor binding and G protein coupling in rat hypothalamus, spinal cord, and primary afferent neurons during inflammatory pain
    Mohammed A Shaqura
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Germany
    J Pharmacol Exp Ther 308:712-8. 2004

Detail Information

Publications365 found, 100 shown here

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo...
  2. ncbi Molecular mechanisms of nociception
    D Julius
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94143, USA
    Nature 413:203-10. 2001
    ....
  3. ncbi A TRP channel that senses cold stimuli and menthol
    Andrea M Peier
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Cell 108:705-15. 2002
    ..Our identification of a cold-sensing TRP channel in a distinct subpopulation of sensory neurons implicates an expanded role for this family of ion channels in somatic sensory detection...
  4. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ..TRPA1 and TRPM8, have been cloned and characterized as possible candidates for cold transducers in primary afferent neurons. Using in situ hybridization histochemistry and immunohistochemistry, we characterized the precise ..
  5. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  6. ncbi Identification of a cold receptor reveals a general role for TRP channels in thermosensation
    David D McKemy
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143 0450, USA
    Nature 416:52-8. 2002
    ....
  7. ncbi Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    Mark J Zylka
    Division of Biology, 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 45:17-25. 2005
    ..Thus, afferent input from different layers of the epidermis is conveyed by topographically segregated sensory circuits, suggesting that at least some aspects of sensory information processing may be organized along labeled lines...
  8. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
    ....
  9. ncbi Time course and nerve growth factor dependence of inflammation-induced alterations in electrophysiological membrane properties in nociceptive primary afferent neurons
    L Djouhri
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 TD, United Kingdom
    J Neurosci 21:8722-33. 2001
    ....
  10. ncbi Characterization of mu opioid receptor binding and G protein coupling in rat hypothalamus, spinal cord, and primary afferent neurons during inflammatory pain
    Mohammed A Shaqura
    Klinik fur Anaesthesiologie und operative Intensivmedizin, Charite Universitatsmedizin Berlin Campus Benjamin Franklin, Germany
    J Pharmacol Exp Ther 308:712-8. 2004
    ..These findings show that inflammation causes changes in MOP receptor binding and G protein coupling after DAMGO stimulation selectively in primary afferent neurons but did not cause any adaptive changes of MOP receptor in HT or SC.
  11. pmc The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
    Laiche Djouhri
    Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
    J Physiol 550:739-52. 2003
    ..Thus high levels of Nav1.8 protein may contribute to the longer AP durations (especially in A-fibre neurons) and larger AP overshoots that are typical of nociceptors...
  12. ncbi The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons
    Xin Fang
    Department of Physiology, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
    J Neurosci 22:7425-33. 2002
    ..The data provide direct evidence that Na(v)1.9 is expressed selectively in (but not in all) C- and A-fiber nociceptive-type units and suggest that Na(v)1.9 contributes to membrane properties that are typical of nociceptive neurons...
  13. ncbi Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
    Sven Eric Jordt
    Department of Cellular and Molecular Pharmacology University of California, San Francisco, California 94143 2140, USA
    Nature 427:260-5. 2004
    ..These findings identify a cellular and molecular target for the pungent action of mustard oils and support an emerging role for TRP channels as ionotropic cannabinoid receptors...
  14. ncbi ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
    Gina M Story
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Cell 112:819-29. 2003
    ..Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol...
  15. pmc Feeding status and serotonin rapidly and reversibly modulate a Caenorhabditis elegans chemosensory circuit
    Michael Y Chao
    Massachusetts General Hospital Center for Cancer Research, 149 7202 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:15512-7. 2004
    ..Our results demonstrate that 5-HT modulation of neuronal activity via G protein signaling underlies behavioral plasticity by rapidly altering the functional circuitry of a chemosensory circuit...
  16. ncbi ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons
    S Arber
    Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Cell 101:485-98. 2000
    ..ER81 therefore controls a late step in the establishment of functional sensory-motor circuitry in the developing spinal cord...
  17. ncbi Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury
    Bryan C Hains
    Department of Neurology and the Paralyzed Veterans of America Eastern Paralyzed Veterans Association Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:4832-9. 2004
    ..3 sodium channel and central mechanisms that contribute to neuropathic pain after peripheral nerve injury...
  18. pmc Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
    S P Sutherland
    The Vollum Institute, Oregon Health Sciences University, Portland, OR 97201 3098, USA
    Proc Natl Acad Sci U S A 98:711-6. 2001
    ....
  19. ncbi Acid-evoked currents in cardiac sensory neurons: A possible mediator of myocardial ischemic sensation
    C J Benson
    Vollum Institute, Division of Cardiology, Oregon Health Sciences University, Portland, Ore 97201 3098, USA
    Circ Res 84:921-8. 1999
    ..0) in signaling ischemia. Acidic pH evoked extremely large depolarizing current in almost all cardiac afferent neurons from the DRG (CDRGNs)...
  20. pmc Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain
    Mohammed A Nassar
    Molecular Nociception Group, Biology Department, and Pharmacology Department, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Proc Natl Acad Sci U S A 101:12706-11. 2004
    ..7 in inflammatory pain. Nociceptor-specific gene ablation should prove useful in understanding the role of other broadly expressed genes in pain pathways...
  21. ncbi An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments
    Y Yang
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Cell 86:655-65. 1996
    ..In BPAG1 null mice, axonal architecture is markedly perturbed, consistent with a failure to tether neurofilaments to the actin cytoskeleton and underscoring the physiological relevance of this protein...
  22. pmc Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach
    Galina Burdyga
    Physiological Laboratory, School of Biomedical Sciences and School of Preclinical Veterinary Science, University of Liverpool, Liverpool, United Kingdom
    J Neurosci 28:11583-92. 2008
    The intestinal hormones CCK and PYY3-36 inhibit gastric emptying and food intake via vagal afferent neurons. Here we report that CCK regulates the expression of Y2R, at which PYY3-36 acts...
  23. pmc Entry of herpes simplex virus type 1 into primary sensory neurons in vitro is mediated by Nectin-1/HveC
    Sarah M Richart
    Department of Microbiology, Colorado State University, Fort Collins, Colorado, USA
    J Virol 77:3307-11. 2003
    ..Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons...
  24. pmc Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics and role in influencing neurochemical phenotype
    Galina Burdyga
    Physiological Laboratory, School of Biomedical Sciences, Univ of Liverpool, Liverpool, L69 3BX, UK
    Am J Physiol Gastrointest Liver Physiol 299:G63-9. 2010
    The intestinal hormone cholecystokinin (CCK) inhibits food intake via stimulation of vagal afferent neurons (VAN)...
  25. pmc GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9
    Johan A R Ostman
    Centre for Neuroscience, Institute of Cell and Molecular Science, Queen Mary University of London, Newark Street, London E1 2AT, UK
    J Physiol 586:1077-87. 2008
    ..9 underlies the G-protein pathway-regulated TTX-r persistent Na(+) current in small diameter sensory neurones that may drive spontaneous discharge in nociceptive nerve fibres during inflammation...
  26. ncbi Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
    Michael Bandell
    Genomics Institute of the Novartis Research Foundation, San Diego, CA 92121, USA
    Neuron 41:849-57. 2004
    ..Collectively, these data demonstrate that TRPA1 activation elicits a painful sensation and provide a potential molecular model for why noxious cold can paradoxically be perceived as burning pain...
  27. ncbi Two interdependent TRPV channel subunits, inactive and Nanchung, mediate hearing in Drosophila
    Zhefeng Gong
    Biology Department, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 24:9059-66. 2004
    ..A functional green fluorescence protein-IAV fusion protein shows that the channel is restricted to the proximal cilium, constraining models for channel activation...
  28. ncbi Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels
    Matthew C Trudeau
    Department of Physiology and Biophysics, Howard Hughes Medical Institute, University of Washington Medical School, Seattle, Washington 98195, USA
    J Biol Chem 278:18705-8. 2003
    ..Here, we will review recent advances in understanding the subunit composition and the mechanisms and roles for Ca2+/CaM-dependent inhibition in olfactory and rod CNG channels...
  29. ncbi Cysteine-rich domain isoforms of the neuregulin-1 gene are required for maintenance of peripheral synapses
    D Wolpowitz
    Columbia University, College of Physicians and Surgeons, Program in Neurobiology and Behavior, New York, New York 10032, USA
    Neuron 25:79-91. 2000
    ....
  30. ncbi A Drosophila mechanosensory transduction channel
    R G Walker
    Department of Biology, Howard Hughes Medical Institute, University of California, San Diego, CA 92093 0649, USA
    Science 287:2229-34. 2000
    ..nompC encodes a new ion channel that is essential for mechanosensory transduction. As expected for a transduction channel, D. melanogaster NOMPC and a Caenorhabditis elegans homolog were selectively expressed in mechanosensory organs...
  31. ncbi Patch clamp electrophysiology in nodose ganglia of adult rat
    B Y Li
    Biomedical Engineering Program, Purdue School of Engineering and Technology, Indiana University, Room SL 174, 723 West Michigan Street, Indianapolis, IN 46202, USA
    J Neurosci Methods 115:157-67. 2002
    ....
  32. ncbi Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
    J B Davis
    Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, UK
    Nature 405:183-7. 2000
    ..We conclude that VR1 is required for inflammatory sensitization to noxious thermal stimuli but also that alternative mechanisms are sufficient for normal sensation of noxious heat...
  33. ncbi Comparisons of somatic action potentials from dispersed and intact rat nodose ganglia using patch-clamp technique
    Bai Yan Li
    Experimental and Computational Neurobiology Laboratory, Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University Purdue University Indianapolis, Indianapolis 46202, USA
    Acta Pharmacol Sin 23:481-9. 2002
    ..To differentiate the electrophysiological characteristics of somatic action potentials (AP) from isolated Neo and Juv nodose sensory neurons (NSN) and those from slices of intact Juv and adult rat nodose ganglia...
  34. pmc Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat
    Satoru Matayoshi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Physiol 569:685-95. 2005
    ..BDNF may thereafter induce monosynaptic Abeta afferents to the SG, thereby developing hyperalgesia and/or allodynia during inflammation...
  35. pmc GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons
    Cheryl L Stucky
    Growth Factors and Regeneration Group, Department of Neuroscience, Max Delbruck Center for Molecular Medicine, Robert Rossle Str 10, Berlin D 13092, Germany
    J Physiol 545:43-50. 2002
    ..Our data are the first to indicate a transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons...
  36. ncbi Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue
    Jesse M Gray
    Howard Hughes Medical Institute and Department of Anatomy, The University of California, San Francisco, California 94143 0452, USA
    Nature 430:317-22. 2004
    ..elegans' preferred level, and require gcy-35 activity. Our results suggest that GCY-35 is regulated by molecular oxygen, and that social feeding can be a behavioural strategy for responding to hyperoxic environments...
  37. ncbi Integrators of the cytoskeleton that stabilize microtubules
    Y Yang
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, Chicago, Illinois 60637, USA
    Cell 98:229-38. 1999
    ..Its isoforms interconnect all three cytoskeletal networks, a feature apparently central to neuronal survival...
  38. ncbi Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice
    M Murakami
    Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan
    Eur J Pharmacol 419:175-81. 2001
    ..Furthermore, it is suggested that some N-type Ca2+ channel blockers might have therapeutic potential as analgesics when applied directly into the subarachnoidal space...
  39. pmc daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway
    Weiqing Li
    Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
    Genes Dev 17:844-58. 2003
    ..This DAF-28 mutant is likely to be poisonous to wild-type DAF-28 and other insulins...
  40. pmc Specificity of afferent synapses onto plane-polarized hair cells in the posterior lateral line of the zebrafish
    Aaron Nagiel
    Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, The Rockefeller University, New York, New York 10065 6399, USA
    J Neurosci 28:8442-53. 2008
    ..Moreover, afferent neurons reassume their biased innervation pattern after hair-cell ablation and regeneration...
  41. ncbi Expression of cannabinoid CB1 receptors by vagal afferent neurons is inhibited by cholecystokinin
    Galina Burdyga
    Physiological Laboratory, University of Liverpool, Liverpool L69 3BX, United Kingdom
    J Neurosci 24:2708-15. 2004
    ..In the case of the satiety hormone cholecystokinin (CCK), these effects are mediated via vagal afferent neurons. We now report that vagal afferent neurons expressing the CCK-1 receptor also express cannabinoid CB1 ..
  42. pmc GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones
    Mark D Baker
    Molecular Nociception Group, Department of Biology, Medawar Building, University College London, Gower Street, UK
    J Physiol 548:373-82. 2003
    ..These findings suggest that regulation of the persistent current has important consequences for nociceptor excitability...
  43. ncbi Intrinsic primary afferent neurons and nerve circuits within the intestine
    John B Furness
    Department of Anatomy and Cell Biology and Centre for Neuroscience, University of Melbourne, Parkville, VIC 3010, Australia
    Prog Neurobiol 72:143-64. 2004
    Intrinsic primary afferent neurons (IPANs) of the enteric nervous system are quite different from all other peripheral neurons...
  44. ncbi C. elegans responds to chemical repellents by integrating sensory inputs from the head and the tail
    Massimo A Hilliard
    International Institute of Genetics and Biophysics, CNR, 80131 Naples, Italy
    Curr Biol 12:730-4. 2002
    ..Our results suggest that C. elegans senses repellents by defining a head-to-tail spatial map of the chemical environment...
  45. ncbi Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
    Neuron 34:885-93. 2002
    ..Thus, stimulating cAMP signaling increases the intrinsic growth capacity of injured sensory axons. This approach may be useful in promoting regeneration after spinal cord injury...
  46. pmc Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    J Pain 8:263-72. 2007
    ..Thus, whereas only an approximately 10% overlap was observed in TG neurons of mouse, significantly greater overlap (approximately 35%) was observed in those of rat...
  47. ncbi Rhombomeric organization of vestibular pathways in larval frogs
    H Straka
    Department of Physiology, Ludwig Maximilians Universitat Munchen, 80336 Munich, Germany
    J Comp Neurol 437:42-55. 2001
    ..Comparisons between frogs and other vertebrates suggest that vestibular neurons performing similar computational roles during head movements originate from the same segmental locations in different species...
  48. ncbi Neuronal plasticity: increasing the gain in pain
    C J Woolf
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, MGH East, Charlestown, MA 02129, USA
    Science 288:1765-9. 2000
    ....
  49. ncbi Developmental expression of BPAG1-n: insights into the spastic ataxia and gross neurologic degeneration in dystonia musculorum mice
    J Dowling
    Department of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute, Chicago, Illinois 60637, USA
    Dev Biol 187:131-42. 1997
    ..Collectively, our findings suggest a mechanism for the BPAG1 null phenotype and indicate that different neurons respond differently to the absence of BPAG1-n, a cytoskeletal linker protein...
  50. ncbi Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
    P M Zygmunt
    Department of Clinical Pharmacology, Institute of Laboratory Medicine, University of Lund, Sweden
    Nature 400:452-7. 1999
    ..The vanilloid receptor may thus be another molecular target for endogenous anandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems...
  51. pmc Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization
    Armen N Akopian
    Department of Endodontics, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Physiol 583:175-93. 2007
    ..In conclusion, we propose novel mechanisms whereby TRPA1 activity undergoes pharmacological desensitization through multiple cellular pathways that are agonist dependent and modulated by TRPV1...
  52. ncbi Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons
    R Waldmann
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 272:20975-8. 1997
    ....
  53. ncbi The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity
    Fumimasa Amaya
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 26:12852-60. 2006
    ..9-/- mice. Na(v)1.9 is, we conclude, an effector of the hypersensitivity produced by multiple inflammatory mediators on nociceptor peripheral terminals and therefore plays a key role in mediating peripheral sensitization...
  54. ncbi Specification of thermosensory neuron fate in C. elegans requires ttx-1, a homolog of otd/Otx
    J S Satterlee
    Department of Biology, Volen Center for Complex Systems, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Neuron 31:943-56. 2001
    ..elegans and the vertebrate photosensory circuit, suggesting an evolutionary link between thermosensation and phototransduction...
  55. pmc NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
    S D Dib-Hajj
    Department of Neurology, LCI 707, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 95:8963-8. 1998
    ....
  56. pmc Potassium channels Kv1.1, Kv1.2 and Kv1.6 influence excitability of rat visceral sensory neurons
    Patricia A Glazebrook
    Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44109, USA
    J Physiol 541:467-82. 2002
    ....
  57. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    ..These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects...
  58. pmc Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons
    G A Smith
    Department of Molecular Biology, Schultz Building, Room 301, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 98:3466-70. 2001
    ..The observed movement was compatible with fast axonal flow mediated by multiple microtubule motors. Capsids accumulated at axon terminals, suggesting that spread from infected neurons required cell contact...
  59. ncbi Functional regeneration of sensory axons into the adult spinal cord
    M S Ramer
    Neuroscience Research Centre, Guy s, King s and St Thomas School of Biomedical Sciences, London, UK
    Nature 403:312-6. 2000
    ..Neurotrophic factor treatment may thus serve as a viable treatment in promoting recovery from root avulsion injuries. I..
  60. ncbi Selective expression of a persistent tetrodotoxin-resistant Na+ current and NaV1.9 subunit in myenteric sensory neurons
    Francois Rugiero
    Intégration des Informations Sensorielles, Unite Mixte de Recherche 6150, Centre National de la Recherche Scientifique, 13916 Marseille, France
    J Neurosci 23:2715-25. 2003
    ..TTX-R I(Na) may play an important role in regulating subthreshold electrogenesis and boosting synaptic stimuli, thereby conferring distinct integrative properties to myenteric sensory neurons...
  61. pmc TREK-1, a K+ channel involved in polymodal pain perception
    Abdelkrim Alloui
    Laboratoire de Pharmacologie Médicale EA 3848 INSERM Faculté de Médecine CHU, Clermont Ferrand, France
    EMBO J 25:2368-76. 2006
    ..TREK-1 appears as an important ion channel for polymodal pain perception and as an attractive target for the development of new analgesics...
  62. ncbi Attenuated cold sensitivity in TRPM8 null mice
    Raymond W Colburn
    Analgesics Team, East Coast Research and Early Development, Johnson and Johnson Pharmaceutical Research and Development, L L C, Spring House, PA 19477 0776, USA
    Neuron 54:379-86. 2007
    ..These results suggest that TRPM8 may play an important role in certain types of cold-induced pain in humans...
  63. ncbi Distinct membrane effects of spinal nerve ligation on injured and adjacent dorsal root ganglion neurons in rats
    Damir Sapunar
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Anesthesiology 103:360-76. 2005
    ..An essential first step is identification of electrophysiologic changes in these two neuronal populations after partial nerve damage...
  64. ncbi Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals
    L Vulchanova
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis 55455, USA
    Neuropharmacology 36:1229-42. 1997
    ..These results suggest species differences, although a more extensive study of primate sensory systems is necessary...
  65. ncbi The lateral line of zebrafish: a model system for the analysis of morphogenesis and neural development in vertebrates
    Christine Dambly-Chaudière
    Laboratoire de Neurogénétique, INSERM E343 Université Montpellier II, cc103 Place E Bataillon, 34095 Montpellier, France
    Biol Cell 95:579-87. 2003
    ..We conclude that the lateral line is uniquely suited among vertebrate sensory systems for a molecular, cellular and genetic analysis of pattern formation and of neural development...
  66. pmc TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    J Clin Invest 115:2393-401. 2005
    ..Thus, blocking TRPA1 in sensory neurons might provide a fruitful strategy for treating cold hyperalgesia caused by inflammation and nerve damage...
  67. ncbi A role for neuregulin1 signaling in muscle spindle differentiation
    Simon Hippenmeyer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056, Basel, Switzerland
    Neuron 36:1035-49. 2002
    ....
  68. ncbi Computational modeling suggests that response properties rather than spatial position determine connectivity between olfactory glomeruli
    Christiane Linster
    Cornell University, Mudd Hall, Ithaca, NY 14853, USA
    J Neurophysiol 93:3410-7. 2005
    ....
  69. ncbi Distinct ATP receptors on pain-sensing and stretch-sensing neurons
    S P Cook
    Vollum Institute L 474, Oregon Health Sciences University, Portland 97201 3098, USA
    Nature 387:505-8. 1997
    ..These results support the theory that P2X3 receptors mediate a form of nociception, but also suggest non-nociceptive roles for ATP in sensory neurons...
  70. ncbi Mice deficient in G(olf) are anosmic
    L Belluscio
    Department of Biochemistry and Molecular Biophysics, College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
    Neuron 20:69-81. 1998
    ..These behavioral phenotypes, taken together with the patterns of G(olf) expression, suggest that G(olf) is required for olfactory signal transduction and may also function as an essential signaling molecule more centrally in the brain...
  71. pmc Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
    Christopher J Benson
    Department of Internal Medicine and Psychiatry, and Howard Hughes Medical Institute, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 99:2338-43. 2002
    ..These data indicate that combinations of two or more DEG/ENaC subunits coassemble as heteromultimers to generate transient H(+)-gated currents in mouse DRG neurons...
  72. pmc Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo
    Richard Benton
    Laboratory of Neurogenetics and Behavior, The Rockefeller University, New York, New York, USA
    PLoS Biol 4:e20. 2006
    ....
  73. ncbi In vivo whole-cell recording of odor-evoked synaptic transmission in the rat olfactory bulb
    Jianhua Cang
    Department of Neuroscience, School of Medicine, University of California, San Diego, La Jolla, California 92093 0608, USA
    J Neurosci 23:4108-16. 2003
    ..Furthermore, differences in odor concentration alter the shape of odor-evoked excitatory synaptic responses, the latency of M/T cell spikes, and the timing of M/T cell lateral inhibition...
  74. pmc Voltage is a partial activator of rat thermosensitive TRP channels
    JOSE A MATTA
    Department of Pharmacology, Georgetown University, MedDent SW401, 3900 Reservoir Rd Washington, DC 20007, USA
    J Physiol 585:469-82. 2007
    ..Thus, voltage acts separately but in concert with other stimuli to regulate channel activation, and, therefore, a voltage-sensitive mechanism is unlikely to represent a final, gating mechanism for these channels...
  75. pmc Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na+ current in rat and mouse sensory neurones
    Mark D Baker
    Molecular Nociception Group, Department of Biology, Medawar Building, University College London, UK
    J Physiol 567:851-67. 2005
    ..Numerical simulation of the up-regulation qualitatively reproduced changes in sensory neurone firing properties. The activation of PKC appears to be a necessary step in the GTP-dependent up-regulation of persistent Na(+) current...
  76. pmc Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction
    Pinky Kain
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 28:4745-55. 2008
    ..Our results suggest that G(q)alpha-mediated olfactory transduction in Drosophila requires a phospholipid second messenger the levels of which are regulated by a cycle of phosphatidylinositol 1,4-bisphosphate breakdown and regeneration...
  77. ncbi Molecular evidence from ascidians for the evolutionary origin of vertebrate cranial sensory placodes
    Francoise Mazet
    School of Animal and Microbial Sciences, University of Reading, UK
    J Exp Zool B Mol Dev Evol 304:340-6. 2005
    ..Our interpretation of these findings is that vertebrate placodes and sea squirt siphon primordia have evolved from the same patches of specialised ectoderm present in the common ancestor of the chordates...
  78. ncbi Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals
    Laiche Djouhri
    Department of Physiology, School of Medical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, United Kingdom
    Brain Res Brain Res Rev 46:131-45. 2004
    ..In rat, about 20% of all somatic afferent neurons with Aalpha/beta-fibers were nociceptive...
  79. ncbi Visualizing synaptic ribbons in the living cell
    David Zenisek
    Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 24:9752-9. 2004
    ..Finally, we find that each ribbon in a retinal bipolar cell contains approximately 4000 molecules of RIBEYE, indicating that it is the major component of the synaptic ribbon...
  80. ncbi Acidic pH and capsaicin activate mechanosensitive group IV muscle receptors in the rat
    Ulrich Hoheisel
    Institut fur Pharmakologie und Toxikologie, Charite, Humboldt Universitat, Dorotheenstrasse 94, D 10117 Berlin, Germany
    Pain 110:149-57. 2004
    ..The data show that (1) a high proportion of group IV muscle receptors are responsive to an increased extracellular hydrogen ion concentration, and (2) a subpopulation of these units are sensitive to both acidic pH and ATP...
  81. ncbi A role for BDNF in mechanosensation
    P Carroll
    Department of Neurobiochemistry, Max Planck Institute for Neurobiology, Planegg Martinsried, Germany
    Nat Neurosci 1:42-6. 1998
    ..Postnatal treatment of BDNF +/- mice with recombinant BDNF completely rescued the mechanosensitivity deficit. Therefore BDNF is important for regulating SAM mechanosensitivity, independent of any survival-promoting function...
  82. ncbi Stimulation by capsaicin of duodenal HCO3(-) secretion via afferent neurons and vanilloid receptors in rats: comparison with acid-induced HCO3(-) response
    Shigeru Kagawa
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University Misasagi, Yamashina, Kyoto 607 8414, Japan
    Dig Dis Sci 48:1850-6. 2003
    ..in a dose-dependent manner; this effect was markedly attenuated by chemical ablation of capsaicin-sensitive afferent neurons (CSN) as well as pretreatment with ruthenium red or capsazepine, and significantly mitigated by indomethacin ..
  83. ncbi Nociceptor and hair cell transducer properties of TRPA1, a channel for pain and hearing
    Keiichi Nagata
    Department of Anesthesiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 25:4052-61. 2005
    ..e., noxious) and yet permitting the same cell to ignore sustained stimulation that is subthreshold (i.e., innocuous). Our results support a TRPA1 role in both nociceptor and hair cell transduction...
  84. ncbi Stroking human jejunal mucosa induces 5-HT release and Cl- secretion via afferent neurons and 5-HT4 receptors
    J M Kellum
    Department of Surgery, Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia 23298 0161, USA
    Am J Physiol 277:G515-20. 1999
    ..These results suggest that mucosal stroking induces release of mucosal 5-HT, which activates a 5-HT4 receptor on enteric sensory neurons, evoking a neuronal reflex that stimulates chloride secretion...
  85. ncbi Multiple sensory G proteins in the olfactory, gustatory and nociceptive neurons modulate longevity in Caenorhabditis elegans
    Hannes Lans
    MGC Department of Cell Biology and Genetics, Center for Biomedical Genetics, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Dev Biol 303:474-82. 2007
    ..We expect that the implication of specific G proteins will eventually contribute to the identification of the sensory cues that determine the rate of aging in C. elegans...
  86. ncbi Modulation of ion channels and synaptic transmission by a human sensory neuron-specific G-protein-coupled receptor, SNSR4/mrgX1, heterologously expressed in cultured rat neurons
    Huanmian Chen
    Laboratory of Molecular Physiology, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 8115, USA
    J Neurosci 24:5044-53. 2004
    ....
  87. ncbi Severe neuropathies in mice with targeted mutations in the ErbB3 receptor
    D Riethmacher
    Department of Medical Genetics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    Nature 389:725-30. 1997
    ..Our results indicate that sensory and motor neurons require factors for their survival that are provided by developing Schwann cells...
  88. pmc Selective activation of primary afferent fibers evaluated by sine-wave electrical stimulation
    Kohei Koga
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Pain 1:13. 2005
    ..Thus, the transcutaneous sine-wave stimulation can be applied to evaluate functional changes of sensory transmission by comparing thresholds with the three stimulus frequencies...
  89. pmc Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation
    A Fischer
    Institute for Anatomy and Cell Biology, Philipps University, Marburg, Germany
    J Clin Invest 98:2284-91. 1996
    ..These findings suggest that an induction of sensory neuropeptides in nodose ganglion neurons is crucially involved in the increase of airway hyperreactivity in the late response to allergen challenge...
  90. ncbi Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve
    L E Goehler
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Brain Res 804:306-10. 1998
    ..administration of bacterial endotoxin, an immune stimulant, induces evidence of activation in vagal primary afferent neurons. To determine whether interleukin-1beta (IL-1beta) is part of the molecular pathway leading to this ..
  91. ncbi Slow feature analysis: a theoretical analysis of optimal free responses
    Laurenz Wiskott
    Computational Neurobiology Laboratory, Salk Institute for Biological Studies, San Diego, CA 92186 5800, USA
    Neural Comput 15:2147-77. 2003
    ..Here, a theoretical analysis of the optimization problem solved by SFA is presented, which provides a deeper understanding of the simulation results obtained in previous studies...
  92. pmc EGR1 Is a target for cooperative interactions between cholecystokinin and leptin, and inhibition by ghrelin, in vagal afferent neurons
    Guillaume de Lartigue
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    Endocrinology 151:3589-99. 2010
    ..Our aim was to examine the hypothesis that these interactions occur at the level of vagal afferent neurons via control of the immediate early gene EGR1...
  93. ncbi Excitation of primary afferent neurons by near-infrared light in vitro
    Elizabeth J Katz
    Food and Drug Administration, Center for Devices and Radiological Health, Silver Spring, Maryland 20993, USA
    Neuroreport 21:662-6. 2010
    ..9 mV) suggests that LED is unrelated to the activation of heat-sensitive transient receptor potential cation channel subfamily V member 1 channels. The long duration of LEDs favors an involvement of second messengers...
  94. pmc Cocaine- and amphetamine-regulated transcript mediates the actions of cholecystokinin on rat vagal afferent neurons
    Guillaume de Lartigue
    Physiological Laboratory, School of Biomedical Sciences, University of Liverpool, Liverpool, UK
    Gastroenterology 138:1479-90. 2010
    Cholecystokinin (CCK) acts on vagal afferent neurons to inhibit food intake and gastric emptying; it also increases expression of the neuropeptide cocaine- and amphetamine-regulated transcript (CART), but the significance of this is ..
  95. pmc Functional impact of the hyperpolarization-activated current on the excitability of myelinated A-type vagal afferent neurons in the rat
    Yu hong Zhou
    Department of Pharmacology, Harbin Medical University, Harbin, China
    Clin Exp Pharmacol Physiol 37:852-61. 2010
    ....
  96. ncbi Calcitonin gene-related peptide: a marker for putative primary afferent neurons in the pig small intestinal myenteric plexus?
    Matthias Wolf
    Institute of Anatomy I, Erlangen, Germany
    Anat Rec (Hoboken) 290:1273-9. 2007
    ..peptide (CGRP) has been used as a marker peptide for Dogiel type II neurons, putative intrinsic primary afferent neurons, in the pig enteric nervous system...
  97. ncbi Interactions of sympathetic and primary afferent neurons following nerve injury and tissue trauma
    W Janig
    Physiologisches Institut, Christian Albrechts Universitat zu Kiel, Germany
    Prog Brain Res 113:161-84. 1996
    ..Two categories of influence of the sympathetic neuron on afferent neurons can be distinguished and this distinction seems to be related to whether the coupling between afferent and ..
  98. ncbi Response properties of whisker-associated trigeminothalamic neurons in rat nucleus principalis
    Brandon S Minnery
    Department of Neurobiology, University of Pittsburgh, Pennsylvania 15261, USA
    J Neurophysiol 89:40-56. 2003
    ..Overall, our findings reveal that the stimulus features encoded by primary afferent neurons are reflected in the responses of VPM-projecting PrV neurons, and that significant convergence of information ..
  99. pmc Estrogen and inflammation increase the excitability of rat temporomandibular joint afferent neurons
    Natasha M Flake
    Department of Biomedical Sciences, Dental School, University of Maryland, 666 W Baltimore St, Rm 5 A 12, Baltimore, MD 21201, USA
    J Neurophysiol 93:1585-97. 2005
    ....
  100. ncbi Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
    I Farinas
    Department of Physiology, University of California School of Medicine, San Francisco 94143 0724
    Nature 369:658-61. 1994
    ..16). In particular, neurotrophin-3 is essential for survival of sympathetic and sensory neurons that later become dependent on nerve growth factor or brain-derived neurotrophic factor...
  101. pmc Calcium and calcium-activated currents in vagotomized rat primary vagal afferent neurons
    Eric Lancaster
    The Neuroscience Program, University of Maryland, School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201 1559, USA
    J Physiol 540:543-56. 2002
    ..In conclusion, a subset of vagotomized NGNs have increased Ca(2+) currents and express I(Cl(Ca)). These NGNs respond electrically to increases in [Ca(2+)](i) during regeneration...

Research Grants69

  1. SYMPATHETIC FIBER MODULATION OF NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2003
    ..Such actions would be physiologically and clinically significant, since inhibition of nociceptive primary afferent neurons could alter both peripheral secretion of neuropeptides (reducing neurogenic inflammation), and possibly, ..
  2. Neurotrophins and Neuropeptides in Colon and Bladder Hypersensitivity
    Liya Qiao; Fiscal Year: 2013
    ..symptom overlap involves neuronal cross-activation in the dorsal root ganglia (DRG) where the bladder afferent neurons are sensitized...
  3. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..To test the hypothesis that IL-31 and OSM regulate inflammation, pruritus and pain via an action on primary afferent neurons as well as keratinocytes...
  4. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..is to identify genes and biomolecules that underlie itch, focusing on signaling mechanisms in primary afferent neurons and spinal cord modulatory interneurons...
  5. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ..Specific Aim 3 is to determine if phosphorylation of PKC takes place in the primary afferent neurons when neurogenic inflammation is initiated and develops, and if TRPN/T receptors are up-regulated by the ..
  6. Novel Mechanisms Regulating the Adipocyte-Brain Hepatocyte Axis
    Philipp E Scherer; Fiscal Year: 2013
    ..Project 2 (Elmquist/Mangelsdorf) will focus on vagal afferent neurons in the nodose ganglia that are ideally positioned to serve as a link between peripheral metabolic and ..
  7. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..The data indicate that abnormalities in those receptors in primary afferent neurons may initiate the development of an exaggerated muscle reflex in HF...
  8. Molecular and Cellular Determinants of the Exercise Pressor Reflex in CHF
    Irving H Zucker; Fiscal Year: 2013
    ..oxygen species and inflammation may activate the mitogen-activated protein kinase (MAPK) pathways in muscle afferent neurons. We hypothesize that chronic oxidative stress in muscle afferent terminals initiate activation of the MAPK ..
  9. Exploiting toxins to probe sensory signaling
    David Julius; Fiscal Year: 2012
    ..derivatives to probe the structure and/or function of TRP channels or other receptors expressed by primary afferent neurons or other types of excitable cells...
  10. Development and Functional Analysis of Components of the Zebrafish Serotonin Sign
    Kenneth N Wallace; Fiscal Year: 2012
    ..Enteroendocrine cells secrete a variety of mediators to stimulate afferent neurons. One of the most studied of these cells are serotonin (5-HT) synthesizing enterochromaffin cells...
  11. Cholecystokinin - Role in postprandial gastric motility
    Helen E Raybould; Fiscal Year: 2013
    ..ingestion of a high fat diet inhibits the CCK-induced changes in receptor and peptide expression in vagal afferent neurons, resulting in the persistence of an orexigenic phenotype and reduced satiety...
  12. Vagal afferent cell bodies as sensors of blood-borne factors
    STEPHEN JOHN LEWIS; Fiscal Year: 2010
    ..hypertension, diabetes and inflammatory states affect the synthesis and disposition of receptors in vagal afferent neurons. Our second hypothesis is that the unique functional morphology of the occipital artery-nodose ganglion ..
  13. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    ..The data indicate that abnormalities in those receptors in primary afferent neurons may initiate the development of an exaggerated muscle reflex in HF...
  14. The role of vagal afferent neurons in regulating feeding behavior
    GUILLAUME FH DE LARTIGUE; Fiscal Year: 2013
    ..We have recently demonstrated that vagal afferent neurons (VAN) can integrate these signals and alter expression of receptors and neuropeptide transmitters important ..
  15. SERT KO rats are a model of sex specific visceral pain
    James J Galligan; Fiscal Year: 2013
    ..5-hydroxytryptamine (5-HT, serotonin) and estrogen signaling interact to increase excitability of primary afferent neurons supplying the colon...
  16. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..First identified and cloned in primary sensory afferent neurons in the peripheral nervous system, mounting evidence supports the expression and activity of these channels in ..
  17. Stimulus processing in mammalian vestibular organs
    Ruth Anne Eatock; Fiscal Year: 2012
    ..The proposed research will investigate how vestibular afferent neurons use ion channels to generate patterns of electrical activity with which they encode head motion and position...
  18. Plasticity of micturition-related neurons following spinal cord injury
    Paul C Dolber; Fiscal Year: 2012
    ..Discover the nature and spinal cord targets of bladder afferent neurons responsible for micturition reflexes after SCI...
  19. KINASES IN ION COTRANSPORTER FUNCTION
    Eric J Delpire; Fiscal Year: 2013
    ..particular, directly activate a Na-K-2Cl cotransport (NKCC) mechanism involved in accumulating Cl- in primary afferent neurons. This Cl- accumulation facilitates primary afferent depolarization, presynaptic inhibition, and the filtering ..
  20. FUNCTIONAL ANALYSIS OF CALCIUM CHANNEL MUTATIONS IN TRIGEMINAL NOCICEPTION
    Yuqing Cao; Fiscal Year: 2010
    ..nociceptive circuitry via two possible scenarios: 1) increasing the excitability of trigeminal primary afferent neurons and 2) preferentially weakening the inhibitory synaptic transmission at cervical/medullary dorsal horn...
  21. Mechanism of Medication Overuse Headache and Chronic Migraine Pain
    Frank Porreca; Fiscal Year: 2013
    ..an evoking stimulus? (Aim 1);second, do the persistent pronociceptive changes elicited in dural primary afferent neurons by triptans result in subsequent activation and potentially increased excitability of dural afferent neurons ..
  22. The Exercise Pressor Reflex in Cardiomyopathy
    Mary G Garry; Fiscal Year: 2013
    ..where blood pressure and heart rate increase in response to contraction-induced activation of primary afferent neurons and reflexive changes in autonomic outflow...
  23. The Peripheral and Central Neuronal Circuits that Underlie Itch
    Hyosang Lee; Fiscal Year: 2012
    ..Specific Aim 1 will focus on elucidating the function of two subpopulations of cutaneous afferent neurons that are marked by the expression of either a G protein- coupled receptor, Mrgprd, or an ion channel, TRPV1...
  24. Extrinsic Neural Control of Gastrointestinal Function in the Disordered Bowel
    David R Linden; Fiscal Year: 2012
    ..these neurons coordinate motor, secretory and vascular functions via reflexes initiated by intestinofugal afferent neurons (IFANs) located in the wall of the intestine...
  25. Postsynaptic Activity of Type II Cochlear Afferents
    CATHERINE JEANNE CHALENSKI WEISZ; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The cochlea contains two types of primary afferent neurons, the Type I and Type II spiral ganglion neurons...
  26. Cochlear Neurotransmitters
    William F Sewell; Fiscal Year: 2013
    ..Understanding trafficking could lead to drugs that improve hearing by increasing the sensitivity of afferent neurons to auditory stimuli...
  27. Biophysics and Biomechanics of the Semicircular Canals
    Richard D Rabbitt; Fiscal Year: 2013
    ..The diverse temporal response properties of afferent neurons correlate with projections in the crista ampullaris, but we do not yet know how or if responses depend upon ..
  28. Dry-responsive corneal afferents, TRPM8, and regulation of tears
    Ian D Meng; Fiscal Year: 2013
    ..We have recently discovered that a class of corneal primary afferent neurons, cold cells, which are known to respond to non-noxious cooling, are also activated by drying of the ocular ..
  29. Translational profiling of somatosensory afferent neurons
    David D McKemy; Fiscal Year: 2013
    ..abstract_text> ..
  30. AGRP NEURONS. NMDARs, Spines, Source of Excitatory Input and Downstream Effectors
    Bradford B Lowell; Fiscal Year: 2013
    ..Rabies Mapping and also Channelrhodopsin-Assisted Circuit Mapping, we will identify and assess function of afferent neurons sending glutamatergic input to AgRP neurons...
  31. Membrane properties of neurons controlling jaw function in a mouse model of ALS
    Scott H Chandler; Fiscal Year: 2012
    ..calcium and/or potassium channels in trigeminal motoneurons and presynaptic trigeminal proprioceptive primary afferent neurons occur simultaneously, and contribute to the hyperexcitability previously observed in SOD1 mutant mice...
  32. Elucidating the Role of Type II Afferent Neurons in Auditory Nociception
    EMMA NOEMI FLORES; Fiscal Year: 2013
    ..The information that is obtained will advance understanding of type II afferent connectivity and function, and will help clarify how noxious noise is detected. ..
  33. FUNCTIONAL ANALYSIS OF DISTINCT NOCICEPTOR POPULATIONS
    CHERYL LOUISE STUCKY; Fiscal Year: 2013
    ..nerve terminals, yet the contribution of TRPA1 in either cell type to the net responses of cutaneous primary afferent neurons to mechanical force or cold temperatures is unknown...
  34. Calvarial periosteal afferents in post-traumatic headache
    Dan Levy; Fiscal Year: 2012
    ..We have found that such relatively mild trauma can promote the activation of putative nociceptive afferent neurons that innervate the periosteal lining of the skull...
  35. Mechanisms of mechanosensory transduction in Merkel cells
    Ellen A Lumpkin; Fiscal Year: 2013
    ..They are made up of epidermal Merkel cells and the terminals of somatosensory afferent neurons. This application focuses on mouse Merkel cell-neurite complex physiology because it is the mammalian touch ..
  36. Biomimetic stimulation of the sacral DRG to control continence and micturition
    ANDRE ELLIOTT SNELLINGS; Fiscal Year: 2010
    ..wires and subsequently multi-electrode arrays will be used to record single unit activity from sacral afferent neurons. The firing pattern and rate of these neurons will be recorded during a series of controlled bladder function ..
  37. Imaging Taste in Ensembles of Afferent Neurons
    Stephen D Roper; Fiscal Year: 2013
    ..high-impact project that introduces a novel method for recording taste-evoked activity in gustatory afferent neurons. The work represents a major new direction for the PIs as well as for the chemical senses community, and thus ..
  38. Nociceptive Mechanisms Underlying Sickle Cell Pain
    CHERYL LOUISE STUCKY; Fiscal Year: 2012
    ..Aims provide a multifaceted, coordinated and tightly focused approach that will clarify the role of primary afferent neurons in the development of pain syndromes within the complex setting of sickle cell-induced vascular and organ ..
  39. The role of TRPA1 neurons in inflammatory pain
    David D McKemy; Fiscal Year: 2012
    ..know how this type of pathology leads to molecular, cellular, and anatomical changes in specific cohorts of afferent neurons that mediate such sensitization...
  40. Infrared Photoactivation of Inner-Ear Hair Cells
    Richard D Rabbitt; Fiscal Year: 2013
    ..semicircular canal crista ampullaris in vivo evokes dramatic and highly controllable responses of first order afferent neurons. Many afferents phase lock to the stimulus and fire an action potential for each IR pulse...
  41. AMPA receptors: Common role in opiate withdrawal and pain sensitivity
    JOSE A MORON-CONCEPCION; Fiscal Year: 2013
    ..dependence and pain sensitivity at three different levels: 1) hippocampus, 2) spinal cord and 3) primary afferent neurons. The proposed experiments will test the hypothesis that acute withdrawal from repeated morphine ..
  42. Multichannel Microstimulation of Primary Afferent Neurons to Restore Propriocepti
    Michael L Boninger; Fiscal Year: 2013
    ..This work will further the development of a SSNI, critical for the future of BMI based prosthetic limbs, as well as address fundamental questions regarding the role of sensory feedback in the control of normal motor behaviors. ..
  43. Auditory Neural Filters Studied with in vivo Whole-Cell Recordings.
    Joshua X Gittelman; Fiscal Year: 2010
    ..FM direction selectivity is created de novo in the 1C, or is inherited from the synaptic inputs, where the afferent neurons are themselves directionally selective...
  44. Capsaicin-sensitive primary afferent fibers and neuropathic pain
    JENNIFER LYNN GIBBS; Fiscal Year: 2013
    ..Research Plan: Dr. Gibbs has propsed a series of studies to evaluate the role of capsaicin-sensitive primary afferent neurons in mediating NP by performing a cross-sectional study on subjects diagnosed with post- herpetic neuralgia (..
  45. Scaffolding the Transition to Chronic Pain
    NATHANIEL AARON JESKE; Fiscal Year: 2013
    ..A large gap in knowledge exists concerning how neuroplastic changes in primary afferent neurons are integrated to contribute to the development of persistent pain...
  46. Apolipoprotein AIV regulates CCK secretion and potentiates CCK-induced satiation
    Chunmin C Lo; Fiscal Year: 2013
    ..and cellular mechanisms by which CCK and apo AIV interact in the periphery to increase activation of vagal afferent neurons and contribute to limiting meal size...
  47. Neuronal Plasticity Related to TMD and Fibromyalgia
    Dean Dessem; Fiscal Year: 2006
    The long term objective of this project is to elucidate the role of craniofacial primary afferent neurons in musculoskeletal disorders such as temporomandibular disorders (TMD) and fibromyalgia (FM) using animal models...
  48. The Role of NeuroD in the Development of Auditory and Vestibular Neurons
    JENNIFER MICHELLE JONES; Fiscal Year: 2010
    ..2000;Kim et. al., 2001). The aim of this study is to examine the role of NeuroD in the development of the afferent neurons of the cochlea and vestibular organs...
  49. Connectivity of Afferent Neurons in the Zebrafish Posterior Lateral Line
    Eliot R Dow; Fiscal Year: 2012
    ..First, the activity-dependence of afferent neurons to form synapses with hair cells of a single polarity will be tested by inhibiting action potentials with ..
  50. The Role of Oxidized Linoleic Acid Metabolites in NGF Induced Persistent Pain
    MICHAEL ANDREW ESKANDER; Fiscal Year: 2013
    ..potential vanilloid 1 (TRPV1), a ligand gated ion channel expressed on a major subpopulation of nociceptive afferent neurons. Endogenous NGF is elevated in several chronic pain conditions, and a single administration of NGF to healthy ..
  51. Molecular receptors on Group III-IV sensory neurons detecting muscle metabolites
    Alan R Light; Fiscal Year: 2013
    ..the next three years, we propose a comprehensive evaluation of the molecular receptors on group III/IV muscle afferent neurons that endow these specialized endings with the ability to detect and signal the increases in muscle ..
  52. Somatosensory feedback controlling a neuroprosthesis
    Douglas J Weber; Fiscal Year: 2010
    ..g. limb position and velocity) from the firing rate modulations of primary afferent neurons. State feedback is required for closed-loop control of functional electrical stimulation systems, which are ..
  53. Organization and function of hair cell afferent neurons
    JAMES CHIENAN LIAO; Fiscal Year: 2013
    ..know comparatively little about how information is processed at the next level after hair cells;the primary afferent neurons. This proposal focuses on understanding the relationships among morphology, connectivity, physiology, and ..
  54. Neuro-immune mechanisms in carotid body chemoreceptor response to chronic hypoxia
    SALVATORE J FIDONE; Fiscal Year: 2012
    Experiments in recent years have revealed labile electrophysiological and neurochemical phenotypes in primary afferent neurons exposed to specific (chronic) stimulus conditions associated with the development of chronic pain...
  55. AFFERENT MECHANISMS UNDERLYING BLADDER PAIN
    WILLIAM DEGROAT; Fiscal Year: 2009
    ..mediators which sensitize bladder, nociceptors and how these chemical mediators alter ion channels in afferent neurons and thereby change afferent receptor excitability...
  56. PEPTIDERGIC NEURONS IN THE SPINAL CORD
    VIRGINIA SEYBOLD; Fiscal Year: 1999
    ..Specific aim #1 tests the hypothesis that NK3 receptors occur on primary afferent neurons. This hypothesis is based on evidence that tachykinins have excitatory effects on primary afferent neurons ..
  57. The Role of Tooth Mechanoreceptors in Jaw Movement
    Dean Dessem; Fiscal Year: 2006
    ..Three hypotheses are proposed: 1) Trigeminal ganglion jaw muscle and joint primary afferent neurons comprise two general categories with brainstem axonal projections correlated to their functional modalities...
  58. PERIPHERAL CANNABINOIDS AND NEUROGENIC INFLAMMATION
    Kenneth Hargreaves; Fiscal Year: 2002
    ..of cannabinoids would be physiologically and clinically significant, since inhibition of nociceptive primary afferent neurons could alter both peripheral secretion of neuropeptides (reducing neurogenic inflammation), and, possibly, ..
  59. NEURAL CONTROL OF LARGE INTESTINAL MUCOSA
    Helen Cooke; Fiscal Year: 2005
    ..release 5- hydroxytryptamine (5-HT) from enterochromaffin cells and binds to 5-HT1P/4 receptors on submucosal afferent neurons in the reflex to cause epithelial chloride secretion...
  60. Oxytocin enhances afferent synaptic transmission within the NTS.
    JAMES PETERS; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Cranial afferent neurons are the first step in medullary reflex pathways and synapse at the nucleus of the solitary tract (NTS)...
  61. IRRITATION INDUCED PLASTICITY OF MICTURITION PATHWAYS
    MARGARET VIZZARD; Fiscal Year: 2000
    ..least three factors: (1) changes in the properties of peripheral bladder afferent pathways such that bladder afferent neurons respond in an exaggerated manner to normally innocuous stimuli, (2) changes in the properties of afferent ..
  62. Slowing of Transit - The Third Enteric Function of 5-HT
    Henry Lin; Fiscal Year: 2005
    ..have been established: the triggering of the peristaltic and mucosal secretory reflexes via intrinsic primary afferent neurons and gut-to-CNS and gut-to-pancreas communications via extrinsic sensory nerves...
  63. Sensory Coding Among Semicircular Canal Afferent Neurons
    LARRY HOFFMAN; Fiscal Year: 2004
    ..is dedicated to elucidating how head movements are encoded in the discharge characteristics of primary afferent neurons innervating the semicircular canal cristae of the vestibular labyrinth...
  64. DORSAL SPINAL CORD STIMULATION--VASODILATOR MECHANISMS
    Robert Foreman; Fiscal Year: 2001
    ..laboratory has demonstrated that SCS-induced vasodilation is mediated by antidromic activation of primary afferent neurons resulting in release of a vasodilator peptide from peripheral sensory nerve endings...
  65. Biophysical properties and function of primary auditory neurons
    Radha Kalluri; Fiscal Year: 2013
    ..analysis, and computational modeling to explore how the biophysical properties intrinsic to primary auditory afferent neurons shape their physiological responses...
  66. HYPERGLYCEMIA-INDUCED NEURONAL SENSITIZATION
    Judith Richter; Fiscal Year: 2001
    ..The overall hypothesis is that painful diabetic neuropathy results from sensitization both of the primary afferent neurons and of the spinothalamic neurons that conduct the pain signal...
  67. TRYPSIN, PAR-2 AND THE PAIN OF PANCREATITIS
    PANKAJ PASRICHA; Fiscal Year: 2004
    ..then demonstrated that injection of AcPep into the pancreatic duct activated and sensitized pancreas-specific afferent neurons in vivo, as measured by spinal cord Fos expression...
  68. INDUCIBLE ALTERATION OF CGRP IN PRIMARY AFFERENT NEURONS
    KARIN WESTLUND HIGH; Fiscal Year: 1993
    ..To determine if dietary calcium specifically modulates regulation of the expression of CGRP in primary afferent neurons, mRNA levels will be compared to normals in the dietary calcium model and the spontaneously hypertensive rat ..
  69. ESOPHAGO-LARYNGEAL ADDUCTOR REFLEX
    Nancy Bauman; Fiscal Year: 2000
    Stimulation of distal esophageal afferent neurons with 0.5% capsaicin in immature canines elicits an intense response referred to as the Esophago- Laryngeal Adductor Reflex (ELAR)...