oligodendroglia

Summary

Summary: A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.

Top Publications

  1. ncbi A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
    John D Cahoy
    Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 28:264-78. 2008
  2. pmc Oligodendroglia metabolically support axons and contribute to neurodegeneration
    Youngjin Lee
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nature 487:443-8. 2012
  3. pmc Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
    Ursula Funfschilling
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nature 485:517-21. 2012
  4. ncbi Biology of oligodendrocyte and myelin in the mammalian central nervous system
    N Baumann
    Institut National de la Santé et de la Recherche Médicale U 495, Biology of Neuron Glia Interactions, Salpetriere Hospital, Paris, France
    Physiol Rev 81:871-927. 2001
  5. ncbi Astroglia induce neurogenesis from adult neural stem cells
    Hongjun Song
    Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 417:39-44. 2002
  6. ncbi Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    Science 319:1244-7. 2008
  7. pmc MicroRNA-mediated control of oligodendrocyte differentiation
    Xianghui Zhao
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 65:612-26. 2010
  8. pmc Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling
    Kaylene M Young
    Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron 77:873-85. 2013
  9. pmc A critical period for social experience-dependent oligodendrocyte maturation and myelination
    Manabu Makinodan
    F M Kirby Neurobiology Center, Children s Hospital, Boston, MA 02115, USA
    Science 337:1357-60. 2012
  10. ncbi Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
    Akiko Nishiyama
    Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Storrs, Connecticut 06269 3156, USA
    Nat Rev Neurosci 10:9-22. 2009

Research Grants

  1. Cell Cycle Pathways and Spinal Cord Injury
    ALAN IRA FADEN; Fiscal Year: 2011
  2. Regulation of CNS viral persistence
    Cornelia Bergmann; Fiscal Year: 2013
  3. Role of Protease Activated Receptors in Spinal Cord Injury and Repair
    Isobel A Scarisbrick; Fiscal Year: 2013
  4. GMF in CNS inflammation
    Asgar Zaheer; Fiscal Year: 2013
  5. Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain
    Douglas L Rosene; Fiscal Year: 2013
  6. Induced Pluripotent Stem Cell Core for NiNDS Investigators
    John A Kessler; Fiscal Year: 2013
  7. CA IN MYELIN PRODUCING CELLS
    Ken McCarthy; Fiscal Year: 1993
  8. Mechanisms of Hypothermic Neuroprotection in Neonates
    Frances J Northington; Fiscal Year: 2013
  9. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
  10. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2003

Detail Information

Publications293 found, 100 shown here

  1. ncbi A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
    John D Cahoy
    Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 28:264-78. 2008
    ....
  2. pmc Oligodendroglia metabolically support axons and contribute to neurodegeneration
    Youngjin Lee
    Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21205, USA
    Nature 487:443-8. 2012
    b>Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases...
  3. pmc Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
    Ursula Funfschilling
    Max Planck Institute of Experimental Medicine, Department of Neurogenetics, Hermann Rein Strasse 3, D 37075 Gottingen, Germany
    Nature 485:517-21. 2012
    ..Because myelinated axons can use lactate when energy-deprived, our findings suggest a model in which axon-glia metabolic coupling serves a physiological function...
  4. ncbi Biology of oligodendrocyte and myelin in the mammalian central nervous system
    N Baumann
    Institut National de la Santé et de la Recherche Médicale U 495, Biology of Neuron Glia Interactions, Salpetriere Hospital, Paris, France
    Physiol Rev 81:871-927. 2001
    ..There is also a remarkable plasticity of the oligodendrocyte lineage, even in the adult with a certain potentiality for myelin repair after experimental demyelination or human diseases...
  5. ncbi Astroglia induce neurogenesis from adult neural stem cells
    Hongjun Song
    Molecular Neurobiology Laboratory, Howard Hughes Medical Institute at the Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 417:39-44. 2002
    ....
  6. ncbi Ceramide triggers budding of exosome vesicles into multivesicular endosomes
    Katarina Trajkovic
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, 37073 Gottingen, Germany
    Science 319:1244-7. 2008
    ..Purified exosomes were enriched in ceramide, and the release of exosomes was reduced after the inhibition of neutral sphingomyelinases. These results establish a pathway in intraendosomal membrane transport and exosome formation...
  7. pmc MicroRNA-mediated control of oligodendrocyte differentiation
    Xianghui Zhao
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Neuron 65:612-26. 2010
    ..These findings illustrate that miRNAs are important regulators of oligodendrocyte differentiation, providing new targets for myelin repair...
  8. pmc Oligodendrocyte dynamics in the healthy adult CNS: evidence for myelin remodeling
    Kaylene M Young
    Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    Neuron 77:873-85. 2013
    ..The latter would predict that average internode length should decrease with age. Consistent with that, we found that adult-born OLs elaborated much shorter but many more internodes than OLs generated during early postnatal life...
  9. pmc A critical period for social experience-dependent oligodendrocyte maturation and myelination
    Manabu Makinodan
    F M Kirby Neurobiology Center, Children s Hospital, Boston, MA 02115, USA
    Science 337:1357-60. 2012
    ....
  10. ncbi Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
    Akiko Nishiyama
    Department of Physiology and Neurobiology, University of Connecticut, 75 North Eagleville Road, Storrs, Connecticut 06269 3156, USA
    Nat Rev Neurosci 10:9-22. 2009
    ..This Review highlights recent findings and unresolved questions related to the lineage and function of polydendrocytes in the CNS...
  11. ncbi Relapsing and remitting multiple sclerosis: pathology of the newly forming lesion
    Michael H Barnett
    Institute of Clinical Neurosciences, Department of Medicine, University of Sydney, Australia
    Ann Neurol 55:458-68. 2004
    ....
  12. ncbi Axon-glial signaling and the glial support of axon function
    Klaus Armin Nave
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Gottingen, Germany
    Annu Rev Neurosci 31:535-61. 2008
    ..Loss of glial support causes progressive axon degeneration and possibly local inflammation, both of which are likely to contribute to a variety of neuronal diseases in the central and peripheral nervous systems...
  13. pmc Neurodegeneration in a transgenic mouse model of multiple system atrophy is associated with altered expression of oligodendroglial-derived neurotrophic factors
    Kiren Ubhi
    Department of Neurosciences, University of California, San Diego, School of Medicine, La Jolla, California 92093 0624, USA
    J Neurosci 30:6236-46. 2010
    ..These results suggest a mechanism in which alphasyn expression in oligodendrocytes impacts on the trophic support provided by these cells for neurons, perhaps contributing to neurodegeneration...
  14. pmc PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
    Leanne E Rivers
    Wolfson Institute for Biomedical Research, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 11:1392-401. 2008
    ..We found no evidence for astrocyte production in gray or white matter. However, small numbers of projection neurons were generated in the forebrain, especially in the piriform cortex, which is the main target of the olfactory bulb...
  15. pmc CNS-resident glial progenitor/stem cells produce Schwann cells as well as oligodendrocytes during repair of CNS demyelination
    Malgorzata Zawadzka
    MRC Cambridge Centre for Stem Cell Biology and Regenerative Medicine, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Cell Stem Cell 6:578-90. 2010
    ....
  16. pmc NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration
    Shin H Kang
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA
    Neuron 68:668-81. 2010
    ..These results indicate that NG2+ cells in the normal CNS are oligodendrocyte precursors with restricted lineage potential and that cell loss and gliosis are not sufficient to alter the lineage potential of these progenitors...
  17. pmc Terminal differentiation of myelin-forming oligodendrocytes depends on the transcription factor Sox10
    C Claus Stolt
    Institut fur Biochemie, Universitat Erlangen Nurnberg, 91054 Erlangen, Germany
    Genes Dev 16:165-70. 2002
    ..Here we show that Sox10 is restricted in the central nervous system to myelin-forming oligodendroglia. In Sox10-deficient mice progenitors develop, but terminal differentiation is disrupted...
  18. pmc NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
    Ragnhildur Karadottir
    Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 438:1162-6. 2005
    ..These results point to NMDA receptors of unusual subunit composition as a potential therapeutic target for preventing white matter damage in a variety of diseases...
  19. pmc Regulation of oligodendrocyte development and myelination by glucose and lactate
    Johanne E Rinholm
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London WC1E 6BT, UK
    J Neurosci 31:538-48. 2011
    ....
  20. pmc Alpha-synuclein aggregation and Ser-129 phosphorylation-dependent cell death in oligodendroglial cells
    Christine L Kragh
    Department of Medical Biochemistry, University of Aarhus, DK 8000 Aarhus, Denmark, Lundbeck A S, DK 2500 Valby, Denmark
    J Biol Chem 284:10211-22. 2009
    ..Hence, the model predicts that both Ser-129 phosphorylation and aggregation control the toxic alpha-syn pathway in oligodendroglial cells and may represent therapeutic intervention points in multiple system atrophy...
  21. ncbi Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection
    Q Richard Lu
    Department of Cancer Biology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA
    Cell 109:75-86. 2002
    ..Targeted disruption of these two genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors...
  22. ncbi The toll-like receptor TLR4 is necessary for lipopolysaccharide-induced oligodendrocyte injury in the CNS
    Seija Lehnardt
    Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Neurosci 22:2478-86. 2002
    ..Our data provide a general mechanistic link between (1) lipopolysaccharide and similar microbial molecular motifs and (2) injury to oligodendrocytes and myelin as occurs in periventricular leukomalacia and multiple sclerosis...
  23. pmc Quaking regulates Hnrnpa1 expression through its 3' UTR in oligodendrocyte precursor cells
    N Ruth Zearfoss
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS Genet 7:e1001269. 2011
    ..Together, the data show that hnRNP A1 is an important QK target that contributes to its control of myelin gene expression...
  24. pmc The energetics of CNS white matter
    Julia J Harris
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 32:356-71. 2012
    ..Finally, we show that mitochondria in optic nerve axons could sustain measured firing rates with a plausible density of glucose transporters in the nodal membrane, without the need for energy transfer from oligodendrocytes...
  25. ncbi Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination
    Joseph M Antony
    Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Nat Neurosci 7:1088-95. 2004
    ..Thus, syncytin's proinflammatory properties in the nervous system demonstrate a novel role for an endogenous retrovirus protein, which may be a target for therapeutic intervention...
  26. pmc Impaired adult myelination in the prefrontal cortex of socially isolated mice
    Jia Liu
    Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 15:1621-3. 2012
    ..Thus, myelinating oligodendrocytes in the adult PFC respond to social interaction with chromatin changes, suggesting that myelination acts as a form of adult plasticity...
  27. ncbi Primary oligodendrocyte death does not elicit anti-CNS immunity
    Giuseppe Locatelli
    Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland
    Nat Neurosci 15:543-50. 2012
    ..Thus, in contrast with previously reported impairments of oligodendrocyte physiology, diffuse oligodendrocyte death alone or in conjunction with immune activation does not trigger anti-CNS immunity...
  28. pmc Neurite outgrowth inhibitor Nogo-A establishes spatial segregation and extent of oligodendrocyte myelination
    S Y Christin Chong
    Department of Neurology and Program in Neuroscience, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:1299-304. 2012
    ..Here we show that intercellular interactions between competing oligodendroglia influence the number and length of myelin internodes, referred to as myelinogenic potential, and identify the ..
  29. pmc NG2 glia generate new oligodendrocytes but few astrocytes in a murine experimental autoimmune encephalomyelitis model of demyelinating disease
    Richa B Tripathi
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London, London WC1E 6BT, UK
    J Neurosci 30:16383-90. 2010
    ..PDGFRA/NG2 cells generated very few GFAP(+)-reactive astrocytes (1-2% of all YFP(+) cells) or NeuN(+) neurons (<0.02%). Thus, PDGFRA/NG2 cells act predominantly as a reservoir of new oligodendrocytes in the demyelinated spinal cord...
  30. ncbi Transcriptional profiling reveals evidence for signaling and oligodendroglial abnormalities in the temporal cortex from patients with major depressive disorder
    C Aston
    Neuroscience Discovery Research, Wyeth Research, Princeton, NJ, USA
    Mol Psychiatry 10:309-22. 2005
    ..with changes in cell communication and signal transduction mechanisms that contribute to abnormalities in oligodendroglia and synaptic function...
  31. ncbi Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injury
    Soheila Karimi-Abdolrezaee
    Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
    J Neurosci 26:3377-89. 2006
    ..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI...
  32. pmc Oligodendrocytes: biology and pathology
    Monika Bradl
    Department of Neuroimmunology, Center for Brain Research, Medical University Vienna, Vienna, Austria
    Acta Neuropathol 119:37-53. 2010
    ..Finally, we will lay out the different pathways leading to oligodendrocyte and myelin loss in human CNS diseases, and we will reveal the different principles leading to the restoration of myelin sheaths or to a failure to do so...
  33. ncbi Origin of oligodendrocytes in the subventricular zone of the adult brain
    Benedicte Menn
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7907-18. 2006
    ..Our work identifies SVZ type B cells as progenitors of oligodendrocytes in normal and injured adult brain...
  34. pmc Pathogenesis of cerebral white matter injury of prematurity
    O Khwaja
    Department of Neurology, Children s Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA
    Arch Dis Child Fetal Neonatal Ed 93:F153-61. 2008
    ..This review looks at recent evidence for pathogenetic mechanisms in white matter injury with emphasis on targets for prevention and treatment of injury...
  35. pmc Gliogenesis and glial pathology in depression
    G Rajkowska
    Department of Psychiatry, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    CNS Neurol Disord Drug Targets 6:219-33. 2007
    ..Finally, we will consider the temporal relationship between glial and neuronal cell pathology in depression...
  36. ncbi NG2 cells generate both oligodendrocytes and gray matter astrocytes
    Xiaoqin Zhu
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269 3156, USA
    Development 135:145-57. 2008
    ..These observations suggest that NG2+ cells are precursors of oligodendrocytes and some protoplasmic astrocytes in gray matter...
  37. ncbi Regulation of oligodendrocyte differentiation and myelination
    Ben Emery
    Centre for Neuroscience and Florey Neuroscience Institutes, Level 2, Alan Gilbert Building, The University of Melbourne, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Science 330:779-82. 2010
    ..Studies have also demonstrated an unexpected level of plasticity of myelin in the adult CNS. These recent advances provide new insight into how remyelination may be stimulated in demyelinating disorders such as multiple sclerosis...
  38. pmc Myelin gene regulatory factor is a critical transcriptional regulator required for CNS myelination
    Ben Emery
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
    Cell 138:172-85. 2009
    ..These findings establish MRF as a critical transcriptional regulator essential for oligodendrocyte maturation and CNS myelination...
  39. ncbi Myelin impairs CNS remyelination by inhibiting oligodendrocyte precursor cell differentiation
    Mark R Kotter
    Cambridge Centre for Brain Repair, Department of Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES, United Kingdom
    J Neurosci 26:328-32. 2006
    ..These data identify myelin as an inhibitor of remyelination as well as its well documented inhibition of axon regeneration...
  40. pmc Control of local protein synthesis and initial events in myelination by action potentials
    Hiroaki Wake
    Nervous System Development and Plasticity Section, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA
    Science 333:1647-51. 2011
    ..This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience...
  41. ncbi The life, death, and replacement of oligodendrocytes in the adult CNS
    Dana M McTigue
    Department of Neuroscience and Center for Brain and Spinal Cord Repair, The Ohio State University, Columbus, Ohio, USA
    J Neurochem 107:1-19. 2008
    ....
  42. pmc Postnatal NG2 proteoglycan-expressing progenitor cells are intrinsically multipotent and generate functional neurons
    Shibeshih Belachew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010 2970, USA
    J Cell Biol 161:169-86. 2003
    ..These data show that at least a subpopulation of postnatal NG2-expressing cells are CNS multipotent precursors that may underlie adult hippocampal neurogenesis...
  43. pmc Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present
    Jianrong Li
    Department of Neurology and the F M Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5321-30. 2008
    ....
  44. pmc Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system
    Bastian G Brinkmann
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, Goettingen 37075, Germany
    Neuron 59:581-95. 2008
    ..Thus, NRG1/ErbB signaling is markedly different between Schwann cells and oligodendrocytes that have evolved an NRG/ErbB-independent mechanism of myelination control...
  45. ncbi Microglial activation mediates neurodegeneration related to oligodendroglial alpha-synucleinopathy: implications for multiple system atrophy
    Nadia Stefanova
    Clinical Neurobiology Unit, Neurodegeneration Research Laboratory, Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Mov Disord 22:2196-203. 2007
    ....
  46. ncbi Tumor necrosis factor-α antagonist reduces apoptosis of neurons and oligodendroglia in rat spinal cord injury
    Ke Bing Chen
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Japan
    Spine (Phila Pa 1976) 36:1350-8. 2011
    ..To examine the effects of a tumor necrosis factor (TNF)-α antagonist (etanercept) on rat spinal cord injury and identify a possible mechanism for its action...
  47. pmc Dicer1 and miR-219 Are required for normal oligodendrocyte differentiation and myelination
    Jason C Dugas
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, USA
    Neuron 65:597-611. 2010
    ..Together, these findings show that miR-219 plays a critical role in coupling differentiation to proliferation arrest in the OL lineage, enabling the rapid transition from proliferating OPCs to myelinating OLs...
  48. pmc Arrested oligodendrocyte lineage maturation in chronic perinatal white matter injury
    Kristen N Segovia
    Department of Pediatrics, Oregon Health and Science University, Portland, OR 97239 3098, USA
    Ann Neurol 63:520-30. 2008
    ....
  49. pmc Calcium-permeable AMPA/kainate receptors mediate toxicity and preconditioning by oxygen-glucose deprivation in oligodendrocyte precursors
    Wenbin Deng
    Department of Neurology and Program in Neuroscience, Children s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 100:6801-6. 2003
    ....
  50. ncbi Enhancing remyelination in disease--can we wrap it up?
    Mark R Kotter
    Department of Clinical Neurosciences, MRC Centre for Stem Cells and Regenerative Medicine, University of Cambridge, Addenbrooke s Hospital, Box 167, Hills Road, Cambridge CB22QQ, UK
    Brain 134:1882-900. 2011
    ..We propose a model that may help to provide cues for how remyelination can be therapeutically enhanced in clinical disease...
  51. ncbi Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
    P J Horner
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA
    J Neurosci 20:2218-28. 2000
    ....
  52. pmc NG2-glia as multipotent neural stem cells: fact or fantasy?
    William D Richardson
    Wolfson Institute for Biomedical Research and Research Department of Cell and Developmental Biology, University College London UCL, UK
    Neuron 70:661-73. 2011
    ..We review these developments, highlighting areas of current interest, contention, and speculation...
  53. ncbi Myelin basic protein: a multifunctional protein
    J M Boggs
    Department of Structural Biology and Biochemistry, Research Institute, Hospital for Sick Children, Toronto, Ontario, Canada
    Cell Mol Life Sci 63:1945-61. 2006
    ..Further study of this very abundant protein will reveal how it is utilized by the oligodendrocyte and myelin for different purposes...
  54. pmc Glutamate and ATP signalling in white matter pathology
    Carlos Matute
    Departamento de Neurociencias and CIBERNED, Universidad del Pais Vasco, Leioa, Vizcaya, Spain Neurotek UPV EHU, Parque Tecnologico de Bizkaia, Zamudio, Spain
    J Anat 219:53-64. 2011
    Excessive signalling by excitatory neurotransmitters like glutamate and ATP can be deleterious to neurons and oligodendroglia, and cause disease...
  55. ncbi Control of oligodendrocyte differentiation by the Nkx2.2 homeodomain transcription factor
    Y Qi
    Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Development 128:2723-33. 2001
    ..Consistent with this suggestion, overproduction of Nkx2.2 protein in fibroblast cells can induce gene expression from the proteolipid protein promoter...
  56. ncbi Isolation and culture of rat and mouse oligodendrocyte precursor cells
    Ying Chen
    Department of Developmental Biology and Kent Waldrep Foundation Center for Basic Neuroscience Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Nat Protoc 2:1044-51. 2007
    ..Isolation and culture of a large, homogenous population of rodent OPCs should significantly facilitate studies on OPC lineage progression and their utility in myelin repair after injury...
  57. pmc Peroxynitrite generated by inducible nitric oxide synthase and NADPH oxidase mediates microglial toxicity to oligodendrocytes
    Jianrong Li
    Department of Neurology, Children s Hospital, and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 102:9936-41. 2005
    ..Our results reveal a role for NADPH oxidase in LPS-induced OL death and suggest that peroxynitrite produced by iNOS and NADPH oxidase in activated microglia may play an important role in the pathogenesis of white matter disorders...
  58. ncbi Cell death in models of spinal cord injury
    Michael S Beattie
    Department of Neuroscience, The Ohio State University Medical Center, 333 W 10th Avenue, Columbus, OH 43210, USA
    Prog Brain Res 137:37-47. 2002
    ..Continued study of both contusion models and other new approaches to studying these mechanisms will be needed to maximize strategies for acute and chronic therapies, and for neural repair...
  59. ncbi Remyelination is altered by bone morphogenic protein signaling in demyelinated lesions
    Jennifer K Sabo
    Centre for Neuroscience, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 31:4504-10. 2011
    ..We identified that BMP signaling is active in oligodendroglia and astrocytes within the demyelinated corpus callosum...
  60. pmc Phosphorylation state of Olig2 regulates proliferation of neural progenitors
    Yu Sun
    Department of Cancer Biology, Harvard Medical School and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Neuron 69:906-17. 2011
    ..In the phosphorylated state, Olig2 maintains antineural (i.e., promitotic) functions that are reflected in human glioma cells and in a genetically defined murine model of primary glioma...
  61. ncbi Reactive astrocytes protect tissue and preserve function after spinal cord injury
    Jill R Faulkner
    Department of Neurobiology, University of California, Los Angeles, California 90095 1763, USA
    J Neurosci 24:2143-55. 2004
    ....
  62. pmc IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system
    Jenni Raasch
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Brain 134:1184-98. 2011
    ..Thus, therapies targeting IκB kinase 2 function in non-neuronal cells may represent a promising strategy for the treatment of distinct demyelinating central nervous system diseases...
  63. ncbi Oligodendroglial apoptosis occurs along degenerating axons and is associated with FAS and p75 expression following spinal cord injury in the rat
    S Casha
    Division of Neurosurgery, Toronto Western Research, The University Health Network, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
    Neuroscience 103:203-18. 2001
    ..Activation of the FAS and p75 death receptor pathways may be involved in initiating this process...
  64. pmc Transplanted oligodendrocytes and motoneuron progenitors generated from human embryonic stem cells promote locomotor recovery after spinal cord transection
    Slaven Erceg
    Cellular Reprogramming Laboratory, Centro de Investigación Príncipe Felipe CIPF, Valencia, Spain
    Stem Cells 28:1541-9. 2010
    ..Taken together, these results indicate that OPC and MP derived from hESC could be a useful therapeutic strategy to repair injured spinal cord...
  65. pmc Differentiation of human oligodendrocytes from pluripotent stem cells
    Bao Yang Hu
    Department of Anatomy and Neurology, School of Medicine and Public Health, Waisman Center, WiCell Institute, University of Wisconsin Madison, Madison, Wisconsin, USA
    Nat Protoc 4:1614-22. 2009
    ..This 3-month differentiation protocol consistently yields OPCs of high purity capable of producing myelin sheaths in vivo...
  66. ncbi Efficient differentiation of human embryonic stem cells into oligodendrocyte progenitors for application in a rat contusion model of spinal cord injury
    Candace L Kerr
    Department of Gynecology and Obstetrics and Stem Cell Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Int J Neurosci 120:305-13. 2010
    ..The extent of injury and effect of early cell transplant was measured using behavioral and electrophysiological assessments which demonstrated increased neurological responses in rats transplanted with OPCs compared to controls...
  67. pmc Fingolimod (FTY720) enhances remyelination following demyelination of organotypic cerebellar slices
    Veronique E Miron
    Neuroimmunology Unit, McGill University, Montreal Neurological Institute, 3801 University St, Montreal, QC, Canada, H3A 2B4
    Am J Pathol 176:2682-94. 2010
    ....
  68. pmc Retinoid X receptor gamma signaling accelerates CNS remyelination
    Jeffrey K Huang
    MRC Centre for Stem Cell Biology and Regenerative Medicine and Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Nat Neurosci 14:45-53. 2011
    ..Our results indicate that RXR-γ is a positive regulator of endogenous oligodendrocyte precursor cell differentiation and remyelination and might be a pharmacological target for regenerative therapy in the CNS...
  69. ncbi Broad expression of Toll-like receptors in the human central nervous system
    Malika Bsibsi
    Division of Immunological and Infectious Diseases, TNO Prevention and Health, Leiden, The Netherlands
    J Neuropathol Exp Neurol 61:1013-21. 2002
    ..Together, our data reveal broad and regulated expression of TLRs both in vitro and in vivo by human glia cells...
  70. ncbi From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase
    Eva Maria Krämer-Albers
    Molecular Cell Biology, Department of Biology, Johannes Gutenberg University of Mainz, Bentzelweg 3, Mainz, Germany
    Cell Mol Life Sci 68:2003-12. 2011
    ..Here, we review oligodendroglial Fyn signalling and discuss the role of Fyn in axon-glia interaction mediating myelination...
  71. ncbi Differentiation block of oligodendroglial progenitor cells as a cause for remyelination failure in chronic multiple sclerosis
    T Kuhlmann
    Institute of Neuropathology, University Hospital Munster, Munster, Domagkstr 19, 48149 Munster, Germany
    Brain 131:1749-58. 2008
    ..In summary, we provide evidence that a differentiation block of oligodendroglial progenitors is a major determinant of remyelination failure in chronic multiple sclerosis lesions...
  72. pmc Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination
    Stephen P J Fancy
    Department of Pediatrics and Neurosurgery, Eli and Edythe Broad Institute for Stem Cell Research and Regeneration Medicine and Howard Hughes Medical Institute, University of California, San Francisco, California, USA
    Nat Neurosci 14:1009-16. 2011
    ..Together, these findings indicate that Axin2 is an essential regulator of remyelination and that it might serve as a pharmacological checkpoint in this process...
  73. ncbi Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm
    Frank Cloutier
    University of California at Irvine, Reeve Irvine Research Center, Department of Anatomy, College of Medicine, 2111 Gillespie Neuroscience Research Facility, Irvine, CA 92697 4292, USA
    Regen Med 1:469-79. 2006
    ..In addition, our results indicate that transplantation of human embryonic stem cell-derived oligodendrocyte progenitor cells into the injured spinal cord is not associated with a decline in locomotor function...
  74. pmc Pyramidal neurons are generated from oligodendroglial progenitor cells in adult piriform cortex
    Fuzheng Guo
    Institute for Pediatric Regenerative Medicine, University of California, Davis School of Medicine, Sacramento, California 95817, USA
    J Neurosci 30:12036-49. 2010
    ..Our data suggest that NG2(+)/PDGFRα(+) proteolipid protein promoter-expressing progenitors generate pyramidal glutamatergic neurons within normal adult piriform cortex...
  75. ncbi The neurotoxicant, cuprizone, as a model to study demyelination and remyelination in the central nervous system
    G K Matsushima
    UNC Neuroscience Center, Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, 27599, USA
    Brain Pathol 11:107-16. 2001
    ..g. available knockouts or transgenics on the common genetic background, or pharmacological treatments) which may accelerate or repress the process of demyelination and or remyelination...
  76. ncbi olig2 is required for zebrafish primary motor neuron and oligodendrocyte development
    Hae Chul Park
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37235, USA
    Dev Biol 248:356-68. 2002
    ..One possibility consistent with these data is that Hedgehog signaling, partly by inducing olig2 expression, specifies neural precursor cells that have potential for primary motor neuron or oligodendrocyte fate...
  77. ncbi Nitrosative and oxidative injury to premyelinating oligodendrocytes in periventricular leukomalacia
    Robin L Haynes
    Department of Neurology, Children s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neuropathol Exp Neurol 62:441-50. 2003
    ..Agents that prevent nitrosative and oxidative stress may play a key role in ameliorating PVL in premature infants in the intensive care nursery...
  78. ncbi Neurological and neurodegenerative alterations in a transgenic mouse model expressing human alpha-synuclein under oligodendrocyte promoter: implications for multiple system atrophy
    Clifford W Shults
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92093 0624, USA
    J Neurosci 25:10689-99. 2005
    ..Together, these studies support the contention that accumulation of alpha-syn in oligodendrocytes promotes neurodegeneration and recapitulates several of the key functional and neuropathological features of MSA...
  79. ncbi Late oligodendrocyte progenitors coincide with the developmental window of vulnerability for human perinatal white matter injury
    S A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 21:1302-12. 2001
    ....
  80. pmc Mitochondrial defects in acute multiple sclerosis lesions
    Don Mahad
    The Mitochondrial Research Group, University of Newcastle upon Tyne, UK
    Brain 131:1722-35. 2008
    ..The findings suggest that hypoxia-like tissue injury in Pattern III multiple sclerosis lesions may be due to mitochondrial impairment...
  81. ncbi Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress
    Wensheng Lin
    Department of Neurology, Jack Miller Center for Peripheral Neuropathy, University of Chicago, Chicago, IL 60637, USA
    Brain 129:1306-18. 2006
    ..Thus, these data suggest that IFN-gamma is capable of inhibiting remyelination in demyelinated lesions and that ER stress modulates the response of remyelinating oligodendrocytes to this cytokine...
  82. ncbi Neuron-glia communication in the control of oligodendrocyte function and myelin biogenesis
    Mikael Simons
    Centre for Biochemistry and Molecular Cell Biology, University of Gottingen, Humboldtallee 23, 37073 Gottingen, Germany
    J Cell Sci 119:4381-9. 2006
    ..These interconnections at multiple levels show how neurons and glia cooperate to build a complex network during development...
  83. ncbi Human embryonic stem cells differentiate into oligodendrocytes in high purity and myelinate after spinal cord transplantation
    Gabriel I Nistor
    Reeve Irvine Research Center, Department of Anatomy and Neurobiology, 2111 Gillespie Neuroscience Research Facility, Gillespie Neuroscience Research Facility, College of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Glia 49:385-96. 2005
    ....
  84. pmc Identification of dynamically regulated microRNA and mRNA networks in developing oligodendrocytes
    Pierre Lau
    Division of Intramural Research, National Institute of Neurological Disorders and Stroke National Institutes of Health, Bethesda, Maryland 20892 4479, USA
    J Neurosci 28:11720-30. 2008
    ..We demonstrate that miR-9 interacts with the 3' untranslated region of PMP22 and downregulates its expression. Our results support models in which miRNAs can act as guardians of the transcriptome...
  85. ncbi Promotion of central nervous system remyelination by induced differentiation of oligodendrocyte precursor cells
    Sha Mi
    Biogen Idec, Cambridge, MA 02142, USA
    Ann Neurol 65:304-15. 2009
    ..In this study, we test the ability of anti-LINGO-1 reagents to promote myelination in vitro and remyelination in the rodent adult central nervous system in vivo...
  86. pmc The Sox9 transcription factor determines glial fate choice in the developing spinal cord
    C Claus Stolt
    Institut fur Biochemie, Universität Erlangen Nuremberg, 91054 Erlangen, Germany
    Genes Dev 17:1677-89. 2003
    ....
  87. ncbi Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble alpha-synuclein
    P H Tu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, USA
    Ann Neurol 44:415-22. 1998
    ....
  88. ncbi Platelet-derived growth factor is constitutively secreted from neuronal cell bodies but not from axons
    M Fruttiger
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, UK
    Curr Biol 10:1283-6. 2000
    ..We conclude that PDGF is constitutively secreted from neuronal cell bodies in vivo, but not from axons in white-matter tracts...
  89. ncbi High cholesterol level is essential for myelin membrane growth
    Gesine Saher
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany
    Nat Neurosci 8:468-75. 2005
    ..This shows that cholesterol is an indispensable component of myelin membranes and that cholesterol availability in oligodendrocytes is a rate-limiting factor for brain maturation...
  90. ncbi CXCR4 signaling regulates remyelination by endogenous oligodendrocyte progenitor cells in a viral model of demyelination
    Kevin S Carbajal
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California, USA
    Glia 59:1813-21. 2011
    ..These findings highlight the possibility to manipulate OPCs in order to increase the pool of remyelination-competent cells that can participate in recovery...
  91. ncbi Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination
    Corinna Lappe-Siefke
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    Nat Genet 33:366-74. 2003
    ..Oligodendrocyte dysfunction, such as that in multiple sclerosis lesions, may suffice to cause secondary axonal loss...
  92. pmc Radiation induced CNS toxicity--molecular and cellular mechanisms
    C Belka
    Department of Radiation Oncology, , Hoppe Seyler Str 3,
    Br J Cancer 85:1233-9. 2001
    ..The article reviews the currently available data on the cellular and molecular basis of radiation induced CNS side effects...
  93. ncbi Multiple system atrophy: a primary oligodendrogliopathy
    Gregor K Wenning
    Department of Neurology, Innsbruck Medical University, Innsbruck, Austria
    Ann Neurol 64:239-46. 2008
    ..Although these syndromes vary in their respective cause of oligodendrogliopathy, they have in common myelin disruption that is often followed by axonal dysfunction...
  94. ncbi Selective vulnerability of late oligodendrocyte progenitors to hypoxia-ischemia
    Stephen A Back
    Department of Pediatrics, Oregon Health Sciences University, Portland, Oregon 97201, USA
    J Neurosci 22:455-63. 2002
    ..2001), maturation-dependent vulnerability of OL progenitors to hypoxia-ischemia may underlie the selective vulnerability to PVL of the white matter in the premature infant...
  95. pmc Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Michele D Binder
    Howard Florey Institute, University of Melbourne, Parkville, Victoria 3010, Australia
    J Neurosci 28:5195-206. 2008
    ..Therefore, TAM receptor activation and regulation can independently influence both oligodendrocyte survival and the microglial response after CNS damage...
  96. pmc Mechanisms of regulation of oligodendrocyte development by p38 mitogen-activated protein kinase
    Li Jin Chew
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 30:11011-27. 2010
    ..We show that oligodendrocyte differentiation involves p38-mediated Sox10 regulation and cross talk with parallel ERK and JNK pathways to repress c-Jun activity...
  97. pmc Distinct stages of myelination regulated by gamma-secretase and astrocytes in a rapidly myelinating CNS coculture system
    Trent A Watkins
    Stanford University School of Medicine, Department of Neurobiology, Fairchild Science Building D235, Stanford, CA 94305 5125, USA
    Neuron 60:555-69. 2008
    ..These insights illustrate the value of this defined system for investigating multiple aspects of CNS myelination...
  98. ncbi Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage
    Nicoletta Kessaris
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nat Neurosci 9:173-9. 2006
    ..Notably, the embryonic MGE- and AEP-derived population is eliminated during postnatal life, raising questions about the nature and purpose of the competition...
  99. ncbi Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
    Ainhoa Etxeberria
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC, USA
    Nat Neurosci 13:287-9. 2010
    ..Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons...
  100. pmc Endoplasmic reticulum stress modulates the response of myelinating oligodendrocytes to the immune cytokine interferon-gamma
    Wensheng Lin
    Jack Miller Center for Peripheral Neuropathy, Department of Neurology, University of Chicago, Chicago, IL 60637, USA
    J Cell Biol 169:603-12. 2005
    ..Therefore, the hypersensitivity of PERK+/- mice to IFN-gamma implicates ER stress in demyelinating disorders that are induced by CNS inflammation...
  101. pmc Beta1 integrins are required for normal CNS myelination and promote AKT-dependent myelin outgrowth
    Claudia S Barros
    The Scripps Research Institute, Department of Cell Biology, Institute of Childhood and Neglected Disease, La Jolla, CA 92037, USA
    Development 136:2717-24. 2009
    ..Our data suggest that beta1 integrins play an instructive role in CNS myelination by promoting myelin wrapping in a process that depends on AKT...

Research Grants62

  1. Cell Cycle Pathways and Spinal Cord Injury
    ALAN IRA FADEN; Fiscal Year: 2011
    ..CMS) trauma, and appears to contribute to apoptotic cell death of post-mitotic cells such as neurons and oligodendroglia. It also likely contributes to post-traumatic gliosis and microglial activation...
  2. Regulation of CNS viral persistence
    Cornelia Bergmann; Fiscal Year: 2013
    ..New data suggest that the limited capacity of oligodendroglia to respond to innate signals protect from oligodendroglial dysfunction and myelin loss...
  3. Role of Protease Activated Receptors in Spinal Cord Injury and Repair
    Isobel A Scarisbrick; Fiscal Year: 2013
    ..of SCI-related PAR agonists (KLKs, thrombin and plasmin) in primary spinal cord neurons, astrocytes and oligodendroglia and their sensitivity to neurotoxic agents in vitro...
  4. GMF in CNS inflammation
    Asgar Zaheer; Fiscal Year: 2013
    ..GMF-dependent production of inflammatory cytokines/chemokines in microglia and the subsequent destruction of oligodendroglia (myelin producing cells) and neurons...
  5. Histopathology, Neuroimaging and Mechanism of Myelin Damage in Aging Monkey Brain
    Douglas L Rosene; Fiscal Year: 2013
    ..In Aim 2, multi-label immunofluorescence with BrdU and markers of mature and immature oligodendroglia will assess the capacity to maintain and repair myelin...
  6. Induced Pluripotent Stem Cell Core for NiNDS Investigators
    John A Kessler; Fiscal Year: 2013
    ..and cell biology of human neural stem cells, numerous human neuronal phenotypes, and human astrocytes and oligodendroglia. Further, somatic cells from patients with a variety of neurological diseases can be reprogrammed to allow ..
  7. CA IN MYELIN PRODUCING CELLS
    Ken McCarthy; Fiscal Year: 1993
    ..Four specific aims are listed. (1) To test the hypothesis that oligodendroglia exhibit neuroligand receptors that are developmentally regulated and that these cells are pharmacologically ..
  8. Mechanisms of Hypothermic Neuroprotection in Neonates
    Frances J Northington; Fiscal Year: 2013
    ..Glia, oligodendroglia and astrocytes, clearly contribute to the overall "encephalopathy" resulting from neonatal HI...
  9. Stem Cells and Ischemic Brain Injury
    Walter Low; Fiscal Year: 2003
    ..stem cell population from human bone marrow that is capable of differentiating into neurons, astrocytes, and oligodendroglia in vitro under appropriate culture conditions...
  10. CHORIOAMNIONITIS--CYTOKINES ALTER PERINATAL HEMODYNAMICS
    TOBY YANOWITZ; Fiscal Year: 2003
    ..PVL results from susceptibility of developing oligodendroglia to ischemia and/or cytotoxic effects of IL-1beta, IL-6 and TNF-alpha...
  11. DEMYELINATING DISEASE: VIRAL AND IMMUNE FUNCTION
    Stephen Stohlman; Fiscal Year: 2007
    ..an examination of the role of distinct CD8+ T cell effectors mechanisms in controlling virus replication in oligodendroglia and astrocytes, the mechanisms used by oligodendroglia to resist perforin mediated cytolysis and the negative ..
  12. CHOLESTEROL AND NEURODEGENERATION
    Shutish Patel; Fiscal Year: 2001
    ..The increased expression of apoD in these disorders was predominantly in oligodendroglia that were closely associated with degenerating neurons...
  13. BIOLOGY OF CHROMOSOME 17 LINKED DEMENTIA WITH TAUOPATHY
    Jill Murrell; Fiscal Year: 2000
    ..loss in the central nervous system along with argentophilic, tau-immunopositive inclusions in neurons, and oligodendroglia cells...
  14. REGULATION OF FATTY ACID SYNTHESIS DURING DEVELOPMENT
    Joseph Volpe; Fiscal Year: 1991
    ..model systems in cell culture to provide insight into the following phenomena in differentiating astrocytes, oligodendroglia, and neurons: (1) the interrelations of cholestrerol and dolichol-dolichylphosphate (do1/do1-P) biosyntheses ..
  15. ACETYLCHOLINESTERASE & CHOLINERGIC NEURONS IN THE BRAIN
    LARRY BUTCHER; Fiscal Year: 1992
    ..proteins, (3) histochemical and histologic processing for acetylcholinesterase, Nissl substance, and oligodendroglia, (4) anterograde and retrograde tract-tracing procedures, and (5) biochemical techniques for measurement of ..
  16. INFLAMMATION AND NEONATAL ISCHEMIC BRAIN INJURY
    Faye Silverstein; Fiscal Year: 2004
    ..Aim 3 will evaluate the influence of pro-inflammatory mediators on the vulnerability of oligodendroglia to hypoxia-ischemia...
  17. EFFECTOR MOLECULES IN DEMYELINATING DISEASE
    Anne Cross; Fiscal Year: 2001
    ..Ultrastructurally, it is clear that myelin membranes are a target of attack in MS, and oligodendroglia cells are lost from chronic MS lesions...
  18. NEURAL STEM CELLS AND XENOBIOTIC RESPONSE
    Kenneth Reuhl; Fiscal Year: 2000
    ..cell replication will be characterized using antibodies to specific markers for neurons, astrocytes, or oligodendroglia. Juvenile and adult animals will be examined in parallel to determine whether the response is age-dependent...
  19. GENE EXPRESSION PROFILING OF NEURAL CELLS IN CULTURE
    Gary Banker; Fiscal Year: 2001
    ..gene expression profiling to the three best-defined culture systems for studying the biology of CNS neurons, oligodendroglia, and astroglia...
  20. NEONATAL HYPOXIC-ISCHEMIC WHITE MATTER INJURY
    Faye Silverstein; Fiscal Year: 2003
    ..in situ hybridization and RT-PCR assays were developed to examine injury-induced changes in expression of 2 oligodendroglia (OL)-specific genes, proteolipid protein (PLP), and myelin basic protein (MBP); preliminary findings provide ..
  21. BIOMEDICAL RESEARCH SUPPORT
    LEON HOYER; Fiscal Year: 1991
    ..Investigator, will utilize the laser cytometer to analyze differentiation and proliferation of astroglia and oligodendroglia in culture in normal mice and a myelin deficient mutant, jimpy. (2) Dr...
  22. MOLECULAR EFFECTS OF SPECIFIC HIV PROTEINS ON THE CNS
    Dale Bredesen; Fiscal Year: 1993
    ..with the temperature- sensitive large T antigen gene of SV 40; characterization as neuronal, astroglial, oligodendroglia, or other...
  23. BRAIN GLUCOSE TRANSPORT AND UTILIZATION IN FAS
    Ann Snyder; Fiscal Year: 2001
    ..and mRNA stabilities and post-transcriptional mechanisms will be studied in cultured neurons, astrocytes and oligodendroglia. The second major aim will be to characterize alterations in glucose utilization, indicators of oxidative ..
  24. ETHANOL EFFECTS ON THE DEVELOPMENT OF OLIGODENDROGLIA
    CHRISTINE INGRAHAM; Fiscal Year: 1999
    ..Specific Aim 1 of this proposal is to determine when in their development oligodendroglia are sensitive to ethanol, and which aspects of their development (proliferation, cell death, and/or ..
  25. PLASMALOGENASE AND WHITE MATTER INJURY
    LLOYD HORROCKS; Fiscal Year: 1980
    ..Within the brain, the plasmalogenase is primarily within the particulate portion of the oligodendroglia. Plasmalogenase has been partially purified...
  26. ABUSED OPIATE DRUGS AND NEURAL DEVELOPMENT
    Kurt Hauser; Fiscal Year: 2000
    ..effect of mu opioid receptor activation on the proliferation and survival of neuroblasts, astroglia, and oligodendroglia in vitro...
  27. Human Bone Marrow Derived Neural Stem Cell Therapy
    John Yu; Fiscal Year: 2006
    ..and phenotypically indistinguishable from fetal NSC and could differentiate into neurons, astrocytes, and oligodendroglia. BM-NSC demonstrated tumor tropic behavior in vivo and when inoculated into the hippocampus, engrafted and ..
  28. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2008
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
  29. Mechanisms of axon-NG2 cell interaction
    Akiko Nishiyama; Fiscal Year: 2008
    ..These studies should elucidate the role of NG2 glia in axonal development and regeneration and may lead to novel concepts and design in therapeutic strategies to promote axonal regeneration following injury. ..
  30. BIORAD RADIANCE 2000 CONFOCAL IMAGING SYSTEM
    Akiko Nishiyama; Fiscal Year: 2001
    ..Support for the maintenance of the equipment will be provided by the user group, the Department, the Dean's Office, and the Research Foundation. ..
  31. Regulation of Oligodendrocyte Survival
    Horea Rus; Fiscal Year: 2006
    ..Our proposed studies will provide an unique model system to elucidate the biology of sublethally injured OLG and may lead to the identification of regulatory factors that can enhance OLG survival and remyelination. ..
  32. PROTEOMIC MAPPING OF MYELIN AND ITS MEMBRANE SUBDOMAINS
    Rashmi Bansal; Fiscal Year: 2009
    ....
  33. Cellular Mechanisms of Fetal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2006
    ..Upon completion of this project, we hope to gain insight into strategies to prevent PVL by understanding intrinsic features of the OL progenitor which influence susceptibility to free radical-mediated injury from ischemia. ..
  34. Oligodendrocytes & precursors: toxicity of chemotherapy
    Mark Noble; Fiscal Year: 2005
    ..In addition, we will identify and test means of selectively protecting normal cells from such damage without simultaneously protecting cancer cells in vitro as well as in vivo. ..
  35. Cellular Mechanisms of Perinatal White Matter Injury
    STEPHEN BACK; Fiscal Year: 2005
    ..Through this work we will gain fundamental new insights into the cellular and molecular mechanisms that underlie neonatal white matter injury and, thereby, develop new strategies to prevent PVL. ..
  36. PRECURSOR CELL RENEWAL, OLIGODENDROCYTES & REMYELINATION
    Mark Noble; Fiscal Year: 2001
    ....
  37. CNS PRECURSOR CELL DYSFUNCTION IN DEVELOPMENTAL MALADIES
    Mark Noble; Fiscal Year: 2005
    ..abstract_text> ..
  38. Cellular Mechanisms of Preterm White Matter Injury
    STEPHEN BACK; Fiscal Year: 2003
    ....
  39. Low-level toxicant perturbation of neural cell function
    Mark D Noble; Fiscal Year: 2010
    ....
  40. RNA Trafficking in Neural Cells.
    John Carson; Fiscal Year: 2009
    ..The results may reveal potential new targets for clinical intervention in neurological disease. ..
  41. RNA trafficking in neural cells
    John Carson; Fiscal Year: 2007
    ..Using RNA granules to deliver RNAs encoding novel proteins to the synapse may provide a way to transform the synapse to improve long term memory and to treat diseases that affect the synapse. ..
  42. How do Cx32 and Cx47 mutants cause CNS demyelination?
    JENNIFER ORTHMAN; Fiscal Year: 2007
    ..This work should elucidate the molecular composition of gap junction channels that couple astrocytes and oligodendrocytes. [unreadable] [unreadable]..
  43. Perinatal hypoxia-ischemia, glutamate receptors, and Nitric Oxide Synthase
    Zhengwei Cai; Fiscal Year: 2007
    ..Direct effects of inflammatory cytokines and IGF-1 on survival and differentiation of OLs will be examined in cultures of OLs at various maturation stages. ..
  44. Biacore T100
    John Carson; Fiscal Year: 2006
    ..This quantitative information will enable us to understand how molecular interaction networks mediate specific cell biological processes and how such networks are disrupted in disease [unreadable] [unreadable]..
  45. MYELINATION--ASSEMBLY OF LIPIDS AND PROTEINS
    JOYCE BENJAMINS; Fiscal Year: 2003
    ..abstract_text> ..
  46. Perinatal infection, cytokines and brain injury
    Zhengwei Cai; Fiscal Year: 2008
    ....
  47. Systemic perinatal insults disrupt neurodevelopment
    Shenandoah Robinson; Fiscal Year: 2008
    ..Insights into mechanisms underlying the disruption of perinatal neural development will lead to novel interventions to enhance neural development in neonates, and minimize neurologic deficits. ..
  48. DEVELOPMENTAL EXPRESSION OF NOVOCANS
    Sara Szuchet; Fiscal Year: 2002
    ..This, in turn, would open up new avenues of research concerning the biology of ependymal cells and their role in subventricular zone neurogenesis. ..
  49. REGULATION OF POSTNATAL CORTICAL MULTIPOTENT PROGENITORS
    MARK MEHLER; Fiscal Year: 2002
    ....
  50. ION CHANNELS IN DEMYELINATING DISEASES
    Betty Soliven; Fiscal Year: 2003
    ..In addition, there may be ways to promote remyelination using the K+ channels of OP cells/OLGs as drug targets. ..
  51. IDENTIFICATION & SELECTION OF ADULT NEURAL PRECURSORS
    Steven Goldman; Fiscal Year: 2003
    ..If this work is successful, we may soon need to consider how best to train newly generated networks of replacement neurons and glia to assume lost functions, in diseases as diverse as stroke, trauma, and the neurodegenerations. ..
  52. A-1 Adenosine Receptor Action in Developing Heart
    Scott Rivkees; Fiscal Year: 2005
    ..We anticipate that these studies will identify Rho and ROCK as critical signaling molecules in heart development and reveal that cardiac GTPase activity transduces the effects of adenosine. ..
  53. Radioactive Iodide Therapy of Pediatric Graves' Disease
    Scott A Rivkees; Fiscal Year: 2010
    ....
  54. Augmentation of Neurogenesis and Recovery After Stroke
    Jack Parent; Fiscal Year: 2007
    ..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
  55. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    Regina C Armstrong; Fiscal Year: 2010
    ..These findings can then direct repair strategies that may be a valuable complement to strategies that abrogate myelin damage in MS and other demyelinating diseases. ..
  56. Adult Forebrain Neural Stem Cell Response to Ischemia
    Jack Parent; Fiscal Year: 2005
    ..Progress in these Aims will advance our understanding of adult SVZ neurogenesis in the normal and ischemic brain, and may provide insight into the potential use of neural stem cells for stroke therapy. ..
  57. Mechanisms Regulating Astroglial Lineage Development
    MARK MEHLER; Fiscal Year: 2006
    ..These studies will further our understandingof the molecular mechanisms governing the changing profiles of neural lineage elaboration during embryonic cerebralcortical neurogenesis and gliogenesis. ..
  58. Emerging Strategies: bridging basic and clinical science
    Robin Miskimins; Fiscal Year: 2008
    ..Ample discussion periods and an open forum panel discussion involving the invited speakers will allow for extensive interaction between participants. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Regulation of oligodendrocyte differentiation by BMP
    Judith Grinspan; Fiscal Year: 2004
    ..We will also look at signaling from BMP through a possible downstream mediator, the Id protein family of inhibitors of differentiation. Our preliminary data suggests that Id expression is altered in the BMP mutants. ..
  60. Regulation of adult human oligodendrocyte progenitors
    Steven Goldman; Fiscal Year: 2008
    ..abstract_text> ..
  61. Adenosinergic Mechanisms of Intrauterine Growth Retardation
    Scott A Rivkees; Fiscal Year: 2010
    ..The goals of this proposal are to identify the mechanisms by which adenosine acts to protect the embryo in utero and how altered embryonic adenosine action leads to long-term adverse effects in adulthood. ..