auditory pathways

Summary

Top Publications

  1. ncbi A synaptic basis for auditory-vocal integration in the songbird
    Eric E Bauer
    Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Neurosci 28:1509-22. 2008
  2. ncbi Role of corticofugal feedback in hearing
    Nobuo Suga
    Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:169-83. 2008
  3. ncbi What's to lose and what's to learn: development under auditory deprivation, cochlear implants and limits of cortical plasticity
    Andrej Kral
    Laboratory of Auditory Neuroscience, Department of Neurophysiology and Pathophysiology, University of Hamburg School of Medicine, Germany
    Brain Res Rev 56:259-69. 2007
  4. ncbi Toward a neurophysiological theory of auditory stream segregation
    Joel S Snyder
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Harvard Medical School, MA, USA
    Psychol Bull 133:780-99. 2007
  5. pmc Maturation of intrinsic and synaptic properties of layer 2/3 pyramidal neurons in mouse auditory cortex
    Anne Marie M Oswald
    Center for Neural Science, New York University, 4 Washington Place, Rm 809, New York, NY 10003, USA
    J Neurophysiol 99:2998-3008. 2008
  6. ncbi Processing of low-probability sounds by cortical neurons
    Nachum Ulanovsky
    Department of Physiology, Hebrew University, Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
    Nat Neurosci 6:391-8. 2003
  7. ncbi A GABAergic component in the commissure of the inferior colliculus in rat
    Olga Hernandez
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute for Neuroscience of Castilla y León, University of Salamanca, Salamanca, Spain
    Neuroreport 17:1611-4. 2006
  8. ncbi Interaural time difference processing in the mammalian medial superior olive: the role of glycinergic inhibition
    Michael Pecka
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 28:6914-25. 2008
  9. ncbi Tuning for spectro-temporal modulations as a mechanism for auditory discrimination of natural sounds
    Sarah M N Woolley
    Helen Wills Neuroscience Institute and Department of Psychology, University of California at Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 8:1371-9. 2005
  10. ncbi Auditory cortical projections to the cat inferior colliculus
    J A Winer
    Department of Molecular and Cell Biology, University of California at Berkeley 94720 3200, USA
    J Comp Neurol 400:147-74. 1998

Research Grants

Detail Information

Publications291 found, 100 shown here

  1. ncbi A synaptic basis for auditory-vocal integration in the songbird
    Eric E Bauer
    Department of Neurobiology, Duke University School of Medicine, Durham, North Carolina 27710, USA
    J Neurosci 28:1509-22. 2008
    ..These results establish the functional synaptic linkage between sites of auditory and vocal learning and may identify an important substrate for learned vocal communication...
  2. ncbi Role of corticofugal feedback in hearing
    Nobuo Suga
    Department of Biology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:169-83. 2008
    ..The corticofugal system has multiple functions. One of the most important functions is the improvement and adjustment (reorganization) of subcortical auditory signal processing for cortical signal processing...
  3. ncbi What's to lose and what's to learn: development under auditory deprivation, cochlear implants and limits of cortical plasticity
    Andrej Kral
    Laboratory of Auditory Neuroscience, Department of Neurophysiology and Pathophysiology, University of Hamburg School of Medicine, Germany
    Brain Res Rev 56:259-69. 2007
    ..In consequence, the ability to learn is compromised in sensory deprivation, resulting in a sensitive period for recovery...
  4. ncbi Toward a neurophysiological theory of auditory stream segregation
    Joel S Snyder
    Department of Psychiatry, Veterans Affairs Boston Healthcare System, Harvard Medical School, MA, USA
    Psychol Bull 133:780-99. 2007
    ..Topographic maps of acoustic attributes, stimulus-specific suppression, and competition between representations are among the neurophysiological mechanisms that likely contribute to streaming. A framework for future research is proposed...
  5. pmc Maturation of intrinsic and synaptic properties of layer 2/3 pyramidal neurons in mouse auditory cortex
    Anne Marie M Oswald
    Center for Neural Science, New York University, 4 Washington Place, Rm 809, New York, NY 10003, USA
    J Neurophysiol 99:2998-3008. 2008
    ..We show that these properties combine to produce age-related differential synaptic responses to low- and high-frequency synaptic input that may contribute to differences in auditory processing during development...
  6. ncbi Processing of low-probability sounds by cortical neurons
    Nachum Ulanovsky
    Department of Physiology, Hebrew University, Hadassah Medical School, Box 12272, Jerusalem 91120, Israel
    Nat Neurosci 6:391-8. 2003
    ..Our results thus indicate that A1 neurons, in addition to processing the acoustic features of sounds, may also be involved in sensory memory and novelty detection...
  7. ncbi A GABAergic component in the commissure of the inferior colliculus in rat
    Olga Hernandez
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute for Neuroscience of Castilla y León, University of Salamanca, Salamanca, Spain
    Neuroreport 17:1611-4. 2006
    ..We conclude that monosynaptic inhibitory connections contribute to the inhibition observed in the contralateral inferior colliculus in functional studies of the commissural projection...
  8. ncbi Interaural time difference processing in the mammalian medial superior olive: the role of glycinergic inhibition
    Michael Pecka
    Division of Neurobiology, Department Biology II, Ludwig Maximilians University Munich, D 82152 Martinsried, Germany
    J Neurosci 28:6914-25. 2008
    ..Hence tonic glycine application experimentally decoupled the effect of inhibition from the timing of its inputs. We conclude that, for proper ITD processing, not only is inhibition necessary, but it must also be precisely timed...
  9. ncbi Tuning for spectro-temporal modulations as a mechanism for auditory discrimination of natural sounds
    Sarah M N Woolley
    Helen Wills Neuroscience Institute and Department of Psychology, University of California at Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 8:1371-9. 2005
    ..Additionally, auditory neurons discriminate among zebra finch song segments better than among synthetic sound segments...
  10. ncbi Auditory cortical projections to the cat inferior colliculus
    J A Winer
    Department of Molecular and Cell Biology, University of California at Berkeley 94720 3200, USA
    J Comp Neurol 400:147-74. 1998
    ..The cortico-collicular system may link brainstem and colliculo-thalamic circuits to coordinate premotor and perceptual aspects of hearing...
  11. ncbi Efficient coding of natural sounds
    Michael S Lewicki
    Computer Science Department and Center for the Neural Basis of Cognition, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA
    Nat Neurosci 5:356-63. 2002
    ..These results suggest that auditory nerve fibers encode a broad set of natural sounds in a manner consistent with information theoretic principles...
  12. pmc Tonotopic reorganization of developing auditory brainstem circuits
    Karl Kandler
    Department of Otolaryngology, University of Pittsburgh School of Medicine, Eye and Ear Institute, Pittsburgh, Pennsylvania, USA
    Nat Neurosci 12:711-7. 2009
    ..Tonotopy arises from the coding of frequency along the cochlea and the topographic organization of auditory pathways. The mechanisms that underlie the establishment of tonotopy are poorly understood...
  13. pmc Topographic spread of inferior colliculus activation in response to acoustic and intracochlear electric stimulation
    Russell L Snyder
    Epstein Laboratory, Department of Otolaryngology, University of California, San Francisco, CA 94143 0526, USA
    J Assoc Res Otolaryngol 5:305-22. 2004
    ..Bipolar stimulation with longitudinally oriented VP electrodes produced broad activation that tended to broaden as the separation between electrodes increased...
  14. ncbi Corticofugal regulation of auditory sensitivity in the bat inferior colliculus
    P H Jen
    Division of Biological Sciences, University of Missouri Columbia 65211, USA
    J Comp Physiol A 183:683-97. 1998
    ..We suggest that corticofugal regulation of central auditory sensitivity can provide an animal with a mechanism to regulate acoustic signal processing in the ascending auditory pathway...
  15. pmc The cognitive neuropsychology of auditory hallucinations: a parallel auditory pathways framework
    Johanna C Badcock
    School of Psychiatry and Clinical Neurosciences, The University of Western Australia and Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, Australia, Mail Bag No 1, Claremont, Perth, 6910, Australia
    Schizophr Bull 36:576-84. 2010
    ....
  16. pmc Auditory midbrain implant: a review
    Hubert H Lim
    Department of Biomedical Engineering, University of Minnesota, Minneapolis
    Trends Amplif 13:149-80. 2009
    ..Finally, several issues and hypotheses for why current patients obtain limited speech perception along with several feasible solutions for improving AMI implementation are presented...
  17. ncbi Parallel auditory pathways: projection patterns of the different neuronal populations in the dorsal and ventral cochlear nuclei
    Nell B Cant
    Department of Neurobiology, Duke University Medical Center, P O Box 3209, Durham, NC 27710, USA
    Brain Res Bull 60:457-74. 2003
    ..Giant cells in the dorsal cochlear nucleus also project directly to the inferior colliculus; some of them may convey inhibitory inputs to the contralateral cochlear nucleus as well...
  18. ncbi Electrical stimulation of the midbrain for hearing restoration: insight into the functional organization of the human central auditory system
    Hubert H Lim
    Otorhinolaryngology Department, Hannover Medical University, 30625 Hannover, Germany
    J Neurosci 27:13541-51. 2007
    ..These findings provide some insight into how we may need to stimulate the midbrain to improve hearing performance with the AMI...
  19. ncbi Auditory system development: primary auditory neurons and their targets
    Edwin W Rubel
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle 98195 7923, USA
    Annu Rev Neurosci 25:51-101. 2002
    ..Ganglion cell innervation and synaptic activity are essential for normal development of neurons in the cochlear nucleus...
  20. ncbi Descending projections from the auditory cortex to the inferior colliculus in the gerbil, Meriones unguiculatus
    Victoria M Bajo
    University Laboratory of Physiology, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Comp Neurol 486:101-16. 2005
    ..Descending connections to the gerbil IC form a segregated system in which multiple descending channels originating from different neuronal subpopulations may modulate specific aspects of ascending auditory information...
  21. pmc Own-song recognition in the songbird auditory pathway: selectivity and lateralization
    Colline Poirier
    Bio Imaging Laboratory, Department of Biomedical Sciences, University of Antwerp, B 2020 Antwerp, Belgium
    J Neurosci 29:2252-8. 2009
    ..They also open questions about the evolution of the cognitive skills and lateralization in vertebrates...
  22. ncbi Elimination and strengthening of glycinergic/GABAergic connections during tonotopic map formation
    Gunsoo Kim
    Department of Neurobiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 6:282-90. 2003
    ..These results provide new insights into the mechanisms by which precisely organized inhibitory circuits are established during development...
  23. ncbi Descending projections from auditory cortex modulate sensitivity in the midbrain to cues for spatial position
    Kyle T Nakamoto
    MRC Institute of Hearing Research, University Park, Nottingham, UK
    J Neurophysiol 99:2347-56. 2008
    ..Overall, the sensitivity of the IC neural population to ILD is radically altered by the corticofugal pathway...
  24. pmc A neural representation of pitch salience in nonprimary human auditory cortex revealed with functional magnetic resonance imaging
    Hector Penagos
    Speech and Hearing Bioscience and Technology Program, Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 24:6810-5. 2004
    ..The present data contribute to converging evidence that anterior areas of nonprimary auditory cortex play an important role in processing pitch...
  25. ncbi The ferret auditory cortex: descending projections to the inferior colliculus
    Victoria M Bajo
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford OX1 3PT, UK
    Cereb Cortex 17:475-91. 2007
    ..This pattern of corticocollicular connectivity is consistent with regional differences in physiological properties and provides another basis for subdividing ferret auditory cortex into functionally distinct areas...
  26. ncbi Neural population coding of sound level adapts to stimulus statistics
    Isabel Dean
    Department of Physiology and University College London Ear Institute, UK
    Nat Neurosci 8:1684-9. 2005
    ..This extends the range of sound levels that can be accurately encoded, fine-tuning hearing to the local acoustic environment...
  27. ncbi Reduction of information redundancy in the ascending auditory pathway
    Gal Chechik
    Interdisciplinary Center for Neural Computation, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Neuron 51:359-68. 2006
    ..IC redundancy was largely related to frequency selectivity. Redundancy reduction may be a generic organization principle of neural systems, allowing for easier readout of the identity of complex stimuli in A1 relative to IC...
  28. ncbi Modulation power and phase spectrum of natural sounds enhance neural encoding performed by single auditory neurons
    Anne Hsu
    Neuroscience Institute and Department of Physics, University of California, Berkeley, Berkeley, California 94720 1650, USA
    J Neurosci 24:9201-11. 2004
    ..We found that rate distribution and bandwidth but not reliability were responsible for the higher average information rates found for song-like sounds...
  29. ncbi The calyx of Held
    Ralf Schneggenburger
    Laboratory of Synaptic Mechanisms, Ecole Polytechnique Federale de Lausanne EPFL, Brain Mind Institute, Bâtiment AAB, Station 15, CH 1015 Lausanne, Switzerland
    Cell Tissue Res 326:311-37. 2006
    ..Together, these studies convey the panopoly of presynaptic regulatory processes underlying the regulation of transmitter release, its modulatory control and short-term plasticity within one identified synaptic terminal...
  30. pmc Task-modulated "what" and "where" pathways in human auditory cortex
    Jyrki Ahveninen
    Harvard Medical School Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, CNY 149 13th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 103:14608-13. 2006
    ..This finding suggests that selective-attention effects are feature-specific in the human nonprimary auditory cortex and that they arise from enhanced tuning of receptive fields of task-relevant neuronal populations...
  31. ncbi GABAergic inputs shape responses to amplitude modulated stimuli in the inferior colliculus
    Donald M Caspary
    Department of Pharmacology, Southern Illinois University School of Medicine, 801 N Rutledge, P O Box 19629, Springfield, IL 62794 9629, USA
    Hear Res 168:163-73. 2002
    ..These findings support a role for GABA in shaping selective rate responses to SAM stimuli for a subset of chinchilla IC neurons...
  32. pmc The descending corticocollicular pathway mediates learning-induced auditory plasticity
    Victoria M Bajo
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK
    Nat Neurosci 13:253-60. 2010
    ..The integrity of this descending pathway is therefore critical for learning-induced localization plasticity...
  33. ncbi Corticofugal shaping of frequency tuning curves in the central nucleus of the inferior colliculus of mice
    Jun Yan
    Department of Physiology and Biophysics, Neuroscience Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive, N W, Rm193B, Calgary, Alberta, T2N 4N1, Canada
    J Neurophysiol 93:71-83. 2005
    ..Mechanisms of FTC plasticity were suggested to comprise both corticofugal and local ICC components of excitatory and inhibitory modulation leading to a temporary change of the balance between excitation and inhibition in the ICC...
  34. ncbi The functional anatomy of the normal human auditory system: responses to 0.5 and 4.0 kHz tones at varied intensities
    A H Lockwood
    Centers for Positron Emission Tomography, Veterans Administration Western New York Health Care System, and State University of New York, University at Buffalo, 14215, USA
    Cereb Cortex 9:65-76. 1999
    ..Contrary to predictions based on cochlear membrane mechanics, at each intensity, 4.0 kHz stimuli were more potent activators of the brain than the 0.5 kHz stimuli...
  35. ncbi Intercollicular commissural projections modulate neuronal responses in the inferior colliculus
    Manuel S Malmierca
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca and Institute for Neuroscience of Castilla y León, 37007 Salamanca, Spain
    Eur J Neurosci 21:2701-10. 2005
    ..The results suggest that one function of the commissure of the IC may be to modulate the response gain of IC neurons to acoustic stimulation...
  36. ncbi The distribution of nitric oxide synthase in the inferior colliculus of guinea pig
    E J Coote
    Auditory Group, Institute of Neuroscience, The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH UK
    Neuroscience 154:218-25. 2008
    ..This transition zone may provide a cytoarchitectonic substrate for functional interaction between these two subdivisions...
  37. pmc The multiple functions of T stellate/multipolar/chopper cells in the ventral cochlear nucleus
    Donata Oertel
    Department of Physiology, School of Medicine and Public Health, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA
    Hear Res 276:61-9. 2011
    ..known as T stellate, type I multipolar, planar multipolar, or chopper cells forms one of the major ascending auditory pathways through the brainstem...
  38. ncbi Lateralization, connectivity and plasticity in the human central auditory system
    Dave R M Langers
    Department of Radiology, Maastricht University Hospital, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    Neuroimage 28:490-9. 2005
    ..Input connection strengths were different only at cortical levels, and there was no evidence for plastic reorganization at subcortical levels...
  39. ncbi Auditory attention--focusing the searchlight on sound
    Jonathan B Fritz
    Centre for Auditory and Acoustic Research, Institute for Systems Research, University of Maryland, College Park, MD 20742, USA
    Curr Opin Neurobiol 17:437-55. 2007
    ....
  40. pmc Aging alters the perception and physiological representation of frequency: evidence from human frequency-following response recordings
    Christopher G Clinard
    Department of Speech and Hearing Sciences, University of Washington, 1417 N E 42nd St, Box 354875, Seattle, WA 98105, USA
    Hear Res 264:48-55. 2010
    ..Although perception and neural representation concurrently declined, one was not predictive of the other...
  41. pmc A population rate code of auditory space in the human cortex
    Nelli H Salminen
    Department of Biomedical Engineering and Computational Science, Helsinki University of Technology, Helsinki, Finland
    PLoS ONE 4:e7600. 2009
    ..Previous work on the human auditory cortex has revealed areas specialized in spatial processing but how the neurons in these areas represent the location of a sound source remains unknown...
  42. ncbi Pre- and postsynaptic properties of glutamatergic transmission in the immature inhibitory MNTB-LSO pathway
    Daniel T Case
    Neuroscience Graduate Program, McMaster Univ, 1280 Main St West, Hamilton, ON L8S 4K1 Canada
    J Neurophysiol 106:2570-9. 2011
    ..Differing neurotransmitter release probabilities could allow the synapse to switch between GABA/glycinergic transmission and mixed glutamate/GABA/glycinergic transmission in response to changing patterns of spiking activity...
  43. pmc Defining cortical frequency tuning with recurrent excitatory circuitry
    Bao Hua Liu
    Zilkha Neurogenetic Institute, University of Southern California, 1501 San Pablo Street, Los Angeles, California 90033, USA
    Nat Neurosci 10:1594-600. 2007
    ..Thus, weakly tuned thalamocortical inputs determine the subthreshold responding range, whereas intracortical inputs largely define the tuning. Such circuits may ensure a faithful conveyance of sensory information...
  44. pmc Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset
    Anna K Magnusson
    Division of Neurobiology, Department Biologie II, Ludwig Maximilians University, Martinsried, Germany
    J Physiol 568:497-512. 2005
    ....
  45. pmc Neural circuits underlying adaptation and learning in the perception of auditory space
    Andrew J King
    Department of Physiology, Anatomy and Genetics, Sherrington Building, University of Oxford, Parks Road, Oxford, UK
    Neurosci Biobehav Rev 35:2129-39. 2011
    ....
  46. ncbi The coding of spatial location by single units in the lateral superior olive of the cat. I. Spatial receptive fields in azimuth
    Daniel J Tollin
    Department of Physiology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Neurosci 22:1454-67. 2002
    ..Sensitivity to spatial location was also retained over a wide range of stimulus levels under binaural, but not monaural, conditions...
  47. ncbi Identification of a pathway for intelligible speech in the left temporal lobe
    S K Scott
    Institute of Cognitive Neuroscience and Department of Phonetics and Linguistics, University College London, MRC Clinical Sciences Centre, Cyclotron Unit, Hammersmith Hospital, London, UK
    Brain 123:2400-6. 2000
    ..This novel observation demonstrates a left anterior temporal pathway for speech comprehension...
  48. pmc Temporal processing in the auditory system: insights from cochlear and auditory midbrain implantees
    Colette M McKay
    Audiology and Deafness Research Group, School of Psychological Sciences, University of Manchester, Manchester, M13 9PL, UK
    J Assoc Res Otolaryngol 14:103-24. 2013
    ....
  49. ncbi Distinct pathways involved in sound recognition and localization: a human fMRI study
    P P Maeder
    Service de radiodiagnostic et radiologie interventionnelle, CHUV, Lausanne, Switzerland
    Neuroimage 14:802-16. 2001
    ..Passive listening paradigm revealed segregated pathways on superior temporal gyrus and inferior parietal lobule. Thus, anatomically distinct networks are involved in sound recognition and sound localization...
  50. pmc Hemispheric asymmetry in mid and long latency neuromagnetic responses to single clicks
    Mary F Howard
    Department of Linguistics, University of Maryland, College Park, MD 20742 7505, USA
    Hear Res 257:41-52. 2009
    ....
  51. ncbi GABAergic and glycinergic neural inhibition in excitatory frequency tuning of bat inferior collicular neurons
    Y Lu
    Division of Biological Sciences, University of Missouri-Columbia, MO 65211, USA
    Exp Brain Res 141:331-9. 2001
    ..Application of both drugs was most effective in abolishing the inhibitory FTCs of IC neurons. The implications of these findings for bat echolocation are discussed...
  52. pmc Effects of sound level on fMRI activation in human brainstem, thalamic and cortical centers
    Irina S Sigalovsky
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    Hear Res 215:67-76. 2006
    ..The present results add to the body of parametric data in normal human listeners and are fundamental to the design of any fMRI experiment employing continuous noise...
  53. pmc Interdependent encoding of pitch, timbre, and spatial location in auditory cortex
    Jennifer K Bizley
    Department of Physiology, Anatomy, and Genetics, University of Oxford, Oxford OX1 3PT, United Kingdom
    J Neurosci 29:2064-75. 2009
    ..Such nonlinearities were most prevalent in primary auditory cortex, although they tended to be small compared with stimulus main effects...
  54. ncbi Corticofugal reorganization of the midbrain tonotopic map in mice
    J Yan
    Department of Physiology and Biophysics, Neuroscience Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive, Calgary, Alberta, T2N 4N1, Canada
    Neuroreport 12:3313-6. 2001
    ..Our data suggest that the auditory cortex reorganizes midbrain tonotopy on the basis of which cortical frequencies are stimulated, mostly probably through corticofugal projections...
  55. pmc Representation of con-specific vocalizations in the core and belt areas of the auditory cortex in the alert macaque monkey
    Gregg H Recanzone
    Department of Neurobiology, Center for Neuroscience, University of California at Davis, Davis, California 95616, USA
    J Neurosci 28:13184-93. 2008
    ..They further suggest that a more complex processing scheme is in play in these early auditory cortical areas...
  56. ncbi Different subthreshold mechanisms underlie song selectivity in identified HVc neurons of the zebra finch
    R Mooney
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 20:5420-36. 2000
    ..Because of the two relay cell types' subthreshold differences, factors affecting their resting membrane potentials could enable them to transmit distinct song representations to their targets...
  57. ncbi Contralateral inhibition as a sensory bias: the neural basis for a female preference in a synchronously calling bushcricket, Mecopoda elongata
    Heiner Römer
    Zoology, Karl Franzens University Graz, Universitatsplatz 2, Austria
    Eur J Neurosci 15:1655-62. 2002
    ..Here we show that contralateral inhibition, the neural basis for lateral contrast enhancement in the auditory pathways of insects and vertebrates, is also the probable proximate neural mechanism for this female preference...
  58. ncbi Brain imaging of the effects of lidocaine on tinnitus
    Samuel A Reyes
    Department of Communicative Disorders and Sciences, State University of New York at Buffalo, Buffalo, NY 14214, USA
    Hear Res 171:43-50. 2002
    ..In addition, generalized lidocaine effects were found in the basal ganglia, thalamus, and a region spanning the Rolandic fissure...
  59. ncbi Neural correlations increase between consecutive processing levels in the auditory system of locusts
    A Vogel
    Department of Biology, Institute of Behavioural Physiology, Humboldt University Berlin, Invalidenstr 43, 10115 Berlin, Germany
    J Neurophysiol 97:3376-85. 2007
    ..Thus we could show that in most cases no serious errors are made if one determines variability by following the usual procedure on the basis of single-cell recordings...
  60. ncbi Auditory responses in multiple sensorimotor song system nuclei are co-modulated by behavioral state
    Jessica A Cardin
    Department of Biology and Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurophysiol 91:2148-63. 2004
    ..Together with the suppression of HVC auditory responses by muscimol in NIf, these results suggest that NIf plays an important role in the flow of auditory information to HVC...
  61. pmc Effects of reverberation on brainstem representation of speech in musicians and non-musicians
    Gavin M Bidelman
    Department of Speech Language Hearing Sciences, Purdue University, West Lafayette, Indiana 47907 2038, USA
    Brain Res 1355:112-25. 2010
    ....
  62. ncbi Auditory discrimination of amplitude modulations based on metric distances of spike trains
    Sandra Wohlgemuth
    Department of Biology, Humboldt University, Berlin, Germany
    J Neurophysiol 97:3082-92. 2007
    ..This shift in temporal resolution does not primarily depend on the investigated stimulus space. Rather it appears to reflect a transformation of how amplitude modulations are represented at more central stages of processing...
  63. pmc Going native: voltage-gated potassium channels controlling neuronal excitability
    Jamie Johnston
    MRC Toxicology Unit, University of Leicester, Leicester, LE1 9HN, UK
    J Physiol 588:3187-200. 2010
    ..An emerging theme is activity-dependent phosphorylation of Kv channel activity and suggests that intracellular signalling has a dynamic role in refining neuronal excitability and homeostasis...
  64. pmc Cognitive control in auditory working memory is enhanced in musicians
    Karen Johanne Pallesen
    Neuroscience Unit, Institute of Biomedicine Physiology, University of Helsinki, Helsinki, Finland
    PLoS ONE 5:e11120. 2010
    ..The results also suggest that superior working memory task performance in musicians rely on an enhanced ability to exert sustained cognitive control. This cognitive benefit in musicians may be a consequence of focused musical training...
  65. ncbi The structure and physiology of the rat auditory system: an overview
    Manuel S Malmierca
    Laboratory for the Neurobiology of Hearing, Department of Cellular Biology and Pathology, Faculty of Medicine, University of Salamanca, Institute for Neuroscience of Castilla y León, Campus Miguel de Unamuno, 37007 Salamanca, Spain
    Int Rev Neurobiol 56:147-211. 2003
  66. pmc Early auditory experience generates long-lasting memories that may subserve vocal learning in songbirds
    Mimi L Phan
    Department of Psychology, Rutgers University, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 103:1088-93. 2006
    ..Furthermore, the strength of this selectivity shows a striking correlation with the fidelity of vocal imitation, suggesting that this auditory memory may have served as the model for song learning...
  67. ncbi Subcortical neural coding mechanisms for auditory temporal processing
    R D Frisina
    Surgery Department, University of Rochester School of Medicine and Dentistry, International Center for Hearing and Speech Research, National Technical Institute for the Deaf, 601 Elmwood Avenue, Rochester, NY 14642 8629, USA
    Hear Res 158:1-27. 2001
    ..Lastly, for gaps and forward masking, as one ascends the auditory system, some suppression effects become quite long (echo suppression), and in some stimulus configurations enhancement to a second sound can take place...
  68. pmc The ability of inferior colliculus neurons to signal differences in interaural delay
    B C Skottun
    Skottun Research, 273 Mather Street, Piedmont, CA 94611 5154, USA
    Proc Natl Acad Sci U S A 98:14050-4. 2001
    ..This finding suggests that the highly accurate sound localization of human observers is consistent with the resolution of single cells and need not reflect the combined activity of many neurons...
  69. ncbi A spike-timing code for discriminating conspecific vocalizations in the thalamocortical system of anesthetized and awake guinea pigs
    Chloé Huetz
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, Unite Mixte de Recherche, Centre National de la Recherche Scientifique 8620, Universite Paris Sud, Orsay, France
    J Neurosci 29:334-50. 2009
    ..These findings emphasize the importance of temporal discharge patterns as a coding mechanism for natural communication sounds, particularly in awake animals...
  70. ncbi Short-term plasticity at the calyx of held
    Henrique von Gersdorff
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon 97201 3098, USA
    Nat Rev Neurosci 3:53-64. 2002
    ..The calyx of Held has also provided fresh insights into the strategies used by synapses to extend their dynamic range of operation and preserve the timing of sensory stimuli...
  71. ncbi Unlearning tinnitus-related cerebral synchrony with acoustic coordinated reset stimulation: theoretical concept and modelling
    Peter A Tass
    Institute of Neuroscience and Medicine Neuromodulation INM 7, Research Center Julich, 52425 Julich, Germany
    Biol Cybern 106:27-36. 2012
    ..Based on our simulations, we propose non-invasive acoustic CR stimulation as a possible novel therapy for tinnitus...
  72. pmc Linking topography to tonotopy in the mouse auditory thalamocortical circuit
    Troy A Hackett
    Vanderbilt Kennedy Center for Research on Human Development, Department of Hearing and Speech Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    J Neurosci 31:2983-95. 2011
    ..Our findings further bridge the gap between in vivo and in vitro approaches for the detailed cellular study of auditory thalamocortical circuit organization and plasticity in the genetically tractable mouse model...
  73. pmc Neural coding of temporal information in auditory thalamus and cortex
    X Wang
    Laboratory of Auditory Neurophysiology, Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Traylor 410, Baltimore, MD 21205, USA
    Neuroscience 154:294-303. 2008
    ..We suggest that such transformations are necessary for the auditory cortex to perform a wide range of functions including sound segmentation, object processing and multi-sensory integration...
  74. ncbi Development of tinnitus-related neuronal hyperactivity through homeostatic plasticity after hearing loss: a computational model
    Roland Schaette
    Department of Biology, Institute for Theoretical Biology, Humboldt Universitat zu Berlin, Invalidenstr 43, 10115 Berlin, Germany
    Eur J Neurosci 23:3124-38. 2006
    ..Our computational model predicts how appropriate additional acoustic stimulation can reverse the development of such hyperactivity, which could provide a new basis for treatment strategies...
  75. pmc Invariance and sensitivity to intensity in neural discrimination of natural sounds
    Cyrus P Billimoria
    Department of Biomedical Engineering, Hearing Research Center, Center for Biodynamics and Program in Mathematical and Computational Neuroscience, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 28:6304-8. 2008
    ..Our results indicate that a temporally sparse spike timing-based code at a primary cortical stage can provide a substrate for intensity-invariant discrimination of natural sounds...
  76. ncbi Coding of auditory space
    Masakazu Konishi
    Division of Biology 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Annu Rev Neurosci 26:31-55. 2003
    ..Thus, the two coding schemes are not alternate methods. Owls can localize sounds by using either the isomorphic map of auditory space in the midbrain or forebrain neural networks in which space is not mapped...
  77. pmc Coding of auditory-stimulus identity in the auditory non-spatial processing stream
    Brian E Russ
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Neurophysiol 99:87-95. 2008
    ..These findings are consistent with the hypothesis that the STG and the vPFC are part of a functional circuit for auditory-identity analysis...
  78. ncbi Serial and parallel processing in rhesus monkey auditory cortex
    J P Rauschecker
    Georgetown Institute for Cognitive and Computational Sciences, Washington, DC 20007, USA
    J Comp Neurol 382:89-103. 1997
    ..PT-responses in area CM, however, appear to be driven by input relayed serially from AI. The direct input to CM from MGd and other thalamic nuclei may thus be capable of mediating responses only to broad-band sounds...
  79. ncbi Adaptive auditory plasticity in developing and adult animals
    Alex S Keuroghlian
    Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305 5125, United States
    Prog Neurobiol 82:109-21. 2007
    ....
  80. ncbi Decoding the auditory corticofugal systems
    Jeffery A Winer
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California at Berkeley, 94720 3200, USA
    Hear Res 212:1-8. 2006
    ..The size, specificity, laminar origins, and morphologic diversity of auditory corticofugal axons is consonant with an interpretation of multiple roles in parallel descending systems...
  81. ncbi Inhibitory synapses in the developing auditory system are glutamatergic
    Deda C Gillespie
    Department of Neurobiology, University of Pittsburgh School of Medicine, W1412 Biomedical Science Tower, 3500 Terrace St, Pittsburgh, Pennsylvania 15261, USA
    Nat Neurosci 8:332-8. 2005
    ..Synapse-specific activation of NMDARs by glutamate release at GABAergic and glycinergic synapses could be important in activity-dependent refinement of inhibitory circuits...
  82. pmc Engaging in an auditory task suppresses responses in auditory cortex
    Gonzalo H Otazu
    Cold Spring Harbor, New York, USA
    Nat Neurosci 12:646-54. 2009
    ..Instead, the engaged condition possesses a characteristic and distinct neural signature in which sound-evoked responses are paradoxically suppressed...
  83. pmc Dynamic range adaptation to sound level statistics in the auditory nerve
    Bo Wen
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Neurosci 29:13797-808. 2009
    ..These findings suggest that adaptive processing of sound levels first occurs in the auditory periphery and is enhanced along the auditory pathway...
  84. ncbi Evolution and function of auditory systems in insects
    A Stumpner
    Institut für Zoologie und Anthropologie, Universitat Gottingen, Germany
    Naturwissenschaften 88:159-70. 2001
    ..Altogether, the many improvements opportunistically evolved at any stage of acoustic information-processing ultimately allow insects to come up with astonishing acoustic performances similar to those achieved by vertebrates...
  85. pmc In vivo auditory brain mapping in mice with Mn-enhanced MRI
    Xin Yu
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Nat Neurosci 8:961-8. 2005
    ..Thus, MEMRI provides a sensitive and effective method for mapping the mouse auditory brainstem and has great potential for a range of functional neuroimaging studies in normal and mutant mice...
  86. ncbi The inferior colliculus of the rat: a quantitative analysis of monaural frequency response areas
    O Hernandez
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute of Neuroscience of Castilla y León and Faculty of Medicine, University of Salamanca, Salamanca, Spain
    Neuroscience 132:203-17. 2005
    ..Comparison of Q values across auditory nuclei shows little evidence that FRAs are sharpened at levels above the auditory nerve. Rather, there is a broad range of frequency tuning properties at each level...
  87. ncbi The planum temporale as a computational hub
    Timothy D Griffiths
    Newcastle University Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Trends Neurosci 25:348-53. 2002
    ..We review the evidence for the model and specific predictions that follow from it...
  88. ncbi Avian superior olivary nucleus provides divergent inhibitory input to parallel auditory pathways
    R Michael Burger
    Virginia Merrill Bloedel Hearing Research Center and Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, Washington 98195 7923, USA
    J Comp Neurol 481:6-18. 2005
    ..We present a conceptual model that incorporates these results and suggest that SON circuitry, in part, functions to offset interaural intensity differences in interaural time difference processing...
  89. ncbi Changes in neuronal activity of the inferior colliculus in rat after temporal inactivation of the auditory cortex
    J Popelar
    Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Physiol Res 52:615-28. 2003
    ..The results reveal the complex changes that appear in IC neuronal activity after functional ablation of the ipsilateral auditory cortex...
  90. pmc Dual streams of auditory afferents target multiple domains in the primate prefrontal cortex
    L M Romanski
    Section of Neurobiology, B 413 SHM, 333 Cedar St, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Neurosci 2:1131-6. 1999
    ..Thus separate auditory streams originate in caudal and rostral auditory cortex and target spatial and non-spatial domains of the frontal lobe, respectively...
  91. ncbi Corticofugal modulation of initial sound processing in the brain
    Feng Luo
    Department of Physiology and Biophysics, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Neurosci 28:11615-21. 2008
    ..The auditory cortex apparently implements a long-range feedback mechanism to select or filter incoming signals from the ear...
  92. pmc Cochlear implant use following neonatal deafness influences the cochleotopic organization of the primary auditory cortex in cats
    James B Fallon
    The Bionic Ear Institute, Melbourne, Victoria, Australia 3002
    J Comp Neurol 512:101-14. 2009
    ....
  93. ncbi Evidence for tinnitus-related plasticity in the auditory and limbic system, demonstrated by arg3.1 and c-fos immunocytochemistry
    C Mahlke
    Department of Neuoracoustics, Institute of Zoology, Darmstadt University of Technology, Darmstadt, Germany
    Hear Res 195:17-34. 2004
    ..In particular in its central nucleus, c-fos and arg3.1 IRN were found exclusively after the tinnitus-inducing treatment, suggesting that coactivation of the AC and the amygdala may by an essential feature of tinnitus-related activation...
  94. pmc Auditory cortex mapmaking: principles, projections, and plasticity
    Christoph E Schreiner
    Coleman Memorial Laboratory, W M Keck Center for Integrative Neuroscience, and Department of Otolaryngology Head and Neck Surgery, University of California San Francisco, San Francisco, CA 94143 0732, USA
    Neuron 56:356-65. 2007
    ..Here, we consider the implications of auditory cortical map organization and its plasticity and evaluate the complementary role of maps in representation and computation from an auditory perspective...
  95. ncbi Expression of a potassium current in inner hair cells during development of hearing in mice
    C J Kros
    Department of Physiology, School of Medical Sciences, University of Bristol, UK
    Nature 394:281-4. 1998
    ..This change in potassium channel expression turns the inner hair cell from a regenerative, spiking pacemaker into a high-frequency signal transducer...
  96. ncbi Cortical reorganization in patients with high frequency cochlear hearing loss
    V Dietrich
    Center of Biomagnetism, Institute of Experimental Audiology, , Germany
    Hear Res 158:95-101. 2001
    ..The results suggest that deafferentation due to cochlear damage in adults may lead to functional reorganization of auditory cortical structures...
  97. pmc Sensitivity to interaural correlation of single neurons in the inferior colliculus of guinea pigs
    Trevor M Shackleton
    MRC Institute of Hearing Research, University Park, Nottingham, NG7 2RD, UK
    J Assoc Res Otolaryngol 6:244-59. 2005
    ..The data suggest that, unlike pure tone interaural time difference, discrimination of a population measure is required to account for behavioral interaural correlation discrimination performance...
  98. ncbi Antidromic activation reveals tonotopically organized projections from primary auditory cortex to the central nucleus of the inferior colliculus in guinea pig
    Hubert H Lim
    Department of Electrical Engineering and Computer Science, University of Michigan, 1301 Beal Ave, Ann Arbor, MI 48109 2122, USA
    J Neurophysiol 97:1413-27. 2007
    ..g., medial geniculate body, cochlear nucleus). Such a method can address some of the limitations with current anatomical techniques for studying the auditory corticofugal system...
  99. ncbi Deficiency of neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to the superior olivary complex in mouse
    Manabu Toyoshima
    Department of Bioengineering, Nagaoka University of Technology, 1603 1, Kamitomiokamachi, Nagaoka, Niigata 940 2188, Japan
    Dev Biol 336:192-200. 2009
    ..Together, these findings suggest that NB-2 deficiency causes a deficit in synapse formation and then induces apoptosis in MNTB and VCN neurons, affecting auditory brainstem function...
  100. pmc Cortical activity patterns predict speech discrimination ability
    Crystal T Engineer
    School of Behavioral and Brain Sciences, University of Texas at Dallas, 800 W Campbell Road, Richardson, Texas 75080, USA
    Nat Neurosci 11:603-8. 2008
    ..This result suggests that spike timing contributes to the auditory cortex representation of consonant sounds...
  101. ncbi Ascending efferent projections of the superior olivary complex
    D L Oliver
    Department of Neuroscience, University of Connecticut Health Center, Farmington, Connecticut 06030 3405, USA
    Microsc Res Tech 51:355-63. 2000
    ..Olivary efferents to the nuclei of the lateral lemniscus are also key components of ascending pathways that inhibit neurons in the midbrain...

Research Grants66

  1. PRESERVATION OF TIMING IN PLASTIC AUDITORY PATHWAYS
    HENRIQUE PRADO VON GERSDORFF; Fiscal Year: 2013
    ....
  2. Motley Diversity Supplement
    Edwin W Rubel; Fiscal Year: 2013
    ..events whereby the integrity and bioelectric activity of the inner influences development of brainstem auditory pathways. Two separate lines of investigation are proposed. 1...
  3. Cholinergic inputs to excitatory and inhibitory midbrain auditory circuits
    JEFFREY GARRETT MELLOTT; Fiscal Year: 2013
    ..excitatory and inhibitory midbrain circuits and their relationships to ascending and descending auditory pathways as well as their relationships to the cholinergic system...
  4. Cross-modal re-organization in children with cochlear implants
    Julia Dee Campbell; Fiscal Year: 2013
    ..this device, age of implantation has been shown to be critical for appropriate stimulation of central auditory pathways and subsequent development of speech and language skills...
  5. DESCENDING SYSTEMS TO THE COCHLEA AND COCHLEAR NUCLEUS
    M Christian Brown; Fiscal Year: 2013
    ..It will also greatly increase our understanding of both the descending and the ascending auditory pathways. This project aims to understand the neural pathways of two brainstem reflexes of the auditory pathway: the ..
  6. Cholesterol Homeostasis in Auditory Function
    MICHELLE LYNN SEYMOUR; Fiscal Year: 2013
    ..sensorineural hearing loss that implicates pathologies affecting the cochlea, auditory nerve and/or central auditory pathways, fundamental information is lacking to explain this relationship...
  7. Anatomical analysis of cortical projections to the auditory midbrain
    KYLE TOKUICHI NAKAMOTO; Fiscal Year: 2012
    ..The results will provide an important step in characterizing descending auditory pathways and their relationships to excitatory and inhibitory midbrain circuits...
  8. Functional anatomy of the auditory system
    Brett R Schofield; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Descending auditory pathways and the pathways that use acetylcholine as a neurotransmitter play critical roles in functions such as ..
  9. Delivery of Channel Rhodopsin for Optogenetic Control of Neurons in the Cochlea
    Daniel J Lee; Fiscal Year: 2013
    ..Optogenetic control of auditory pathways through transduction of SGCs has not yet been reported...
  10. Proteomics of Auditory Brainstem Circuitry During Development and in Deafness
    Raphael Pinaud; Fiscal Year: 2010
    ..studies have focused in the medial nucleus of the trapezoid body (MNTB), a relay station of the ascending auditory pathways involved in the localization of sounds in the horizontal plane, and embedded in the superior olivary complex...
  11. Evoked Potentials and Music Perception: Effects of Hearing Loss and Training
    KAY E GFELLER; Fiscal Year: 2013
    ..These limitations are likely related to the signal processing of CIs as well as limitations in the central auditory pathways, particularly in pediatric populations with congenital hearing loss...
  12. NEURONS AND CIRCUITS OF PERIOLIVARY NUCLEI
    Albert S Berrebi; Fiscal Year: 2013
    ..The inferior colliculus (IC) is a major site for integration of virtually all ascending and descending auditory pathways, and many fundamental characteristics of IC neurons are profoundly shaped by their inhibitory inputs...
  13. Microcircuit Architecture of Top-Down Cortical Modulation of Auditory Pathways
    JASON WILLIAM MIDDLETON; Fiscal Year: 2013
    ....
  14. Spontaneous activity in the developing cochlea
    Dwight E Bergles; Fiscal Year: 2010
    ..that these ATP driven depolarizations of IHCs are responsible for initiating activity in developing auditory pathways. The preservation of this activity in both acute and cultured cochleas in which appropriate cell- cell ..
  15. AGE RELATED SYNAPTIC CHANGES IN THE AUDITORY BRAINSTEM
    Robert Helfert; Fiscal Year: 1999
    ..the central nucleus, and is a critical auditory midbrain processing center for both ascending and descending auditory pathways. Neurons in the IC perform spatial and temporal coding of complex signals, sound localization, and are ..
  16. Molecular neuroanatomy of the cochlear nucleus in deafness
    Maria E Rubio; Fiscal Year: 2010
    ..They form part of the neuron population that initiates the ascending auditory pathways by which auditory information is communicated to higher centers...
  17. Characterizing Central Auditory Neurons in Drosophila melanogaster
    Allison E Baker; Fiscal Year: 2013
    ..signals during courtship, but little is known about the representation of acoustic stimuli in central auditory pathways. The goal of this study is to understand how central auditory neurons transform acoustic signals downstream ..
  18. Presbycusis: Biomedical Risk Factors
    GEORGE GATES; Fiscal Year: 2005
    ..Is the poor speech understanding due to Alzheimer lesions in the auditory pathways, or in the frontal executive control centers that regulate speech processing and attention? Why do most ..
  19. Functional Architecture of Auditory Pathways from Inferior Colliculus to Cortex
    Douglas C Fitzpatrick; Fiscal Year: 2013
    ....
  20. NEUROBIOLOGY OF SENSORY ACQUISITION
    Patrice Adret; Fiscal Year: 2001
    ..This includes (1) the ascending auditory pathways; (2) several higher- order auditory areas including the caudomedial neostriatum (Ncm); (3) the anterior ..
  21. Developmental Studies of Sound Localization Mechanisms
    DANIEL TOLLIN; Fiscal Year: 2003
    ..cues used to determine the spatial location of sound sources and the neural circuits in the ascending auditory pathways that encode these cues...
  22. NIGROTECTAL GABA NEURONS IN ALCOHOL AND KINDLED SEIZURES
    Joanna Peris; Fiscal Year: 1991
    ..are the basis for the seizure susceptibility or are caused by seizure activity transmitted through the auditory pathways including IC...
  23. PARALLEL AUDITORY PATHWAYS IN THE BRAIN STEM
    Ellen Covey; Fiscal Year: 2006
    ..Understanding how information from different sources is integrated in the IC could ultimately have implications for diagnosis and treatment of central hearing and language disorders. ..
  24. CELL SURVIVAL IN A NEURAL CIRCUIT FOR LEARNING
    Wei Wu; Fiscal Year: 2010
    ..humans, songbird vocal patterns are controlled by a forebrain network that includes pre-motor, striatal, and auditory pathways for processing vocal sounds and gestures...
  25. Cholinergic Circuitry in Auditory Brainstem
    SUSAN MOTTS; Fiscal Year: 2009
    The inferior colliculus (1C)is a central structure in the brainstem auditory pathways and processes almost all ascending auditory sensory information...
  26. SUPERIOR OLIVE AND DESCENDING AUDITORY PATHWAYS
    JOHN ZOOK; Fiscal Year: 1993
    ..ABSTRACT) The long-term objective is to explore the relationship between the ascending and descending auditory pathways at the level of the superior olive complex...
  27. Cochlear Nucleus Proteomics in a Mouse Model of Age-Related Hearing Loss
    Xian Chen; Fiscal Year: 2007
    ..unreadable] DESCRIPTION (provided by applicant): People that have had AHL will have changes in their central auditory pathways. Our studies (and some other recent studies) have shown that the critical "gateway" cells in the cochlear ..
  28. PROTEIN KINASE C IN CENTRAL AUDITORY PLASTICITY
    Meredith Garcia; Fiscal Year: 2002
    ..proposed in this application will further define how these signaling pathways may interact in central auditory pathways following deafferentation...
  29. ORGANIZATION OF AUDITORY CORTEX
    Jon Kaas; Fiscal Year: 1993
    ..2) their connection patterns with the frontal lobe and limbic system, and (3) the convergence of visual and auditory pathways. All three objectives will be investigated by combining microelectrode recordings and anatomical techniques ..
  30. Neurophysiology Studies of Simulated Auditory Neural Prostheses
    Michael Ferguson; Fiscal Year: 2010
    ..the auditory system that improve the transfer of information supporting speech recognition into surviving auditory pathways. Although this project is directed primarily towards animal studies, the work scope requires careful ..
  31. CELLULAR MECHANISMS OF AUDITORY CORTEX FUNCTION
    Raju Metherate; Fiscal Year: 2001
    ..Conversely, disruption of auditory pathways by injury, or degeneration of diffuse modulatory systems in pathological conditions (e.g...
  32. GENERATION OF AUDITORY SPATIAL RECEPTIVE FIELDS
    Terry Takahashi; Fiscal Year: 1993
    ..Moreover, its auditory pathways have been traced and characterized...
  33. DESCENDING CONNECTIONS OF THE LOWER AUDITORY SYSTEM
    WILLIAM WARR; Fiscal Year: 1992
    The objective is to advance our understanding of the neuroanatomical organization of descending auditory pathways acting at the level of the cochlea and cochlear nucleus in animals, including humans...
  34. INNER EAR AND CENTRAL AUDITORY DEVELOPMENT
    DONALD MOREST; Fiscal Year: 2000
    ..the assembly of the sensorineural structures of the inner ear and the connections with the central auditory pathways. The approach uses in vitro methods to analyze the role of sensorineural interactions in the development of ..
  35. NEUROGENESIS IN THE AUDITORY SYSTEM
    DONALD MOREST; Fiscal Year: 2005
    ..These conditions are associated with degeneration and reorganization of the central auditory pathways, To understand better these conditions, we need to acquire some insight into the factors that account for ..
  36. Acoustic modulation of the neuroendocrine axis
    Christopher Leary; Fiscal Year: 2009
    ..to be directly relevant to many other vertebrate species as well, including humans, given that the central auditory pathways among vertebrates are largely conserved in their overall structural organization and numerous unctional ..
  37. COCHLEAR GRANULE CELL SYSTEM--RELAY FOR DESCENDING INPUT
    Jean Moore; Fiscal Year: 1990
    ..Ascending auditory pathways analyze the physical characteristics of a stimulus, but descending pathways control the access of the ..
  38. The thalamocortical synapse in layers IV and VI
    Charles Lee; Fiscal Year: 2009
    ..will be to investigate the synaptic properties of the thalamocortical projection in the somatosensory and auditory pathways. The theoretical impetus motivating these studies is to understand the role of higher order thalamic relays ..
  39. FUNCTIONAL ORGANIZATION OF INFERIOR COLLICULUS
    GEORGE POLLAK; Fiscal Year: 2007
    ..The roles of inhibition in this processing may be especially relevant for the decline of speech perception in the elderly, which is correlated with age related loss of GABAergic neurons in the auditory system. ..
  40. Studies of the Central Auditory System
    Bradford May; Fiscal Year: 2007
    ..abstract_text> ..
  41. Central Auditory System Plasticity in Implanted Children
    Anu Sharma; Fiscal Year: 2005
    ..The long-term objective of this research is to study the development, deterioration, and plasticity of auditory pathways mediating human communication...
  42. FUNCTIONAL PATHWAYS OF THE COCHLEAR NUCLEUS
    JOHN DOUCET; Fiscal Year: 2002
    ..Cochlear nucleus neurons and their neural codes form the foundation of central auditory pathways that are ultimately responsible for our ability to locate and identify a sound: perceptions that ..
  43. FUNCTIONAL ORGANIZATION--NONPRIMARY AUDITORY CORTEX
    JOSEF RAUSCHECKER; Fiscal Year: 2004
    ....
  44. STRUCTURE AND PLASTICITY OF CENTRAL HEARING MECHANISMS
    CRAIG HENKEL; Fiscal Year: 2002
    ..Results should lead to a better understanding of the influence of experience on the development of these binaural sensory pathways. ..
  45. Single neuron correlates of learned song
    Richard Mooney; Fiscal Year: 2004
    ..This project can help identify neural mechanisms important to audition guided vocal learning, and thus may yield insight into neural mechanisms for speech learning, perception and production. ..
  46. HEARING: DEVELOPMENT OF SYNAPTIC CIRCUITS
    CRAIG HENKEL; Fiscal Year: 2005
    ....
  47. Auditory processing of signals in noise
    Bradford May; Fiscal Year: 2006
    ..A better understanding of the brain's signal processing solutions will lead to improved designs for assistive listening devices that now show poor performance in noisy environments. ..
  48. NEUROANATOMY OF THE AUDITORY SYSTEM
    Nell B Cant; Fiscal Year: 2010
    Our long-term goal is to understand the organization of the brainstem auditory pathways in terms of connections among the multiple neuronal types that form them...
  49. Cellular Mechanisms of Vocal-Respiratory Integration
    Richard Mooney; Fiscal Year: 2005
    ..abstract_text> ..
  50. Visual and Auditory Processing Streams in the Cerebral Cortex
    Josef P Rauschecker; Fiscal Year: 2010
    ..abstract_text> ..
  51. SPECTRAL CUES FOR SOUND LOCALIZATION
    Bradford May; Fiscal Year: 2008
    ..Consequently, this research will enhance our current understanding of the processes and perceptions that shape directional hearing, speech processing, and compensation for hearing loss in humans. [unreadable] [unreadable]..
  52. Functions of Corticofugal Auditory System
    Nobuo Suga; Fiscal Year: 2009
    ..All the data obtained will be evaluated in relation to our hypotheses. ..
  53. A New Approach to Sound Source Identification
    Robert Lutfi; Fiscal Year: 2009
    ..abstract_text> ..
  54. NEURONAL BASES OF SOUND LOCALIZATION PERFORMANCE
    DOUGLAS FITZPATRICK; Fiscal Year: 2003
    ..The expected health benefits include the development of devices, software, or prostheses that use the principles discovered to assist hearing-impaired individuals. ..
  55. Optical imaging of neural activity in auditory system
    JAMES KALTENBACH; Fiscal Year: 2004
    ..The significance of these experiments is that they will yield information regarding the dynamics of signal processing and reveal new aspects of DCN circuitry that have been difficult to study electrophysiologically. ..
  56. ANALYSES OF COMMUNICATION SOUNDS IN AUDITORY MIDBRAIN
    CHRISTINE PORTFORS; Fiscal Year: 2005
    ..This study will establish the extent of selectivity among social vocalizations in the IC and the contribution of combination sensitivity to selectivity. ..
  57. 2007 Auditory System and Graduate Research Seminar
    Karl Kandler; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. Group and Individual Differences in Audition
    Dennis McFadden; Fiscal Year: 2010
    ..If so, theory, diagnosis, treatment, and nosology for ADHD could be affected. ..
  59. Hearing loss affects synaptic balance in auditory cortex
    Dan Sanes; Fiscal Year: 2009
    ..Together, the results are significant for understanding at a cellular level how auditory processing is influenced by mild to severe deafness, and how we might compensate for these deficits. ..
  60. CRCNS: Auditory Stream Segregation and the Cocktail Party Problem
    Shihab Shamma; Fiscal Year: 2007
    ..This project will also provide a rigorous foundation for the design and generation of new hypotheses in order to better understand the neural basis of active listening [unreadable] [unreadable]..