afferent pathways

Summary

Summary: Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.

Top Publications

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
  2. ncbi Psychological and neural mechanisms of the affective dimension of pain
    D D Price
    Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
    Science 288:1769-72. 2000
  3. ncbi Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input
    Max F K Happel
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 30:11114-27. 2010
  4. ncbi Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    Ajay Dhaka
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:566-75. 2008
  5. ncbi Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats
    Ming Kui Zhong
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Exp Physiol 93:746-53. 2008
  6. ncbi Superoxide anions in the paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity in renovascular hypertensive rats
    Ying Han
    Dept of Physiology, Nanjing Medical Univ, Nanjing 210029, China
    J Appl Physiol (1985) 110:646-52. 2011
  7. ncbi Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent
    Pablo Rubio-Garrido
    Department of Anatomy and Neuroscience, School of Medicine, Autonoma University, Madrid, Spain
    Cereb Cortex 19:2380-95. 2009
  8. ncbi Afferent-induced facilitation of primary motor cortex excitability in the region controlling hand muscles in humans
    H Devanne
    Neurophysiologie Clinique, CHRU Lille, Hopital Roger Salengro, Lille Cedex, France
    Eur J Neurosci 30:439-48. 2009
  9. pmc Bladder afferent signaling: recent findings
    Anthony Kanai
    Department of Medicine and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 183:1288-95. 2010
  10. pmc Neuronal basis for object location in the vibrissa scanning sensorimotor system
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:455-68. 2011

Detail Information

Publications327 found, 100 shown here

  1. ncbi The capsaicin receptor: a heat-activated ion channel in the pain pathway
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143 0450, USA
    Nature 389:816-24. 1997
    ..The cloned capsaicin receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo...
  2. ncbi Psychological and neural mechanisms of the affective dimension of pain
    D D Price
    Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
    Science 288:1769-72. 2000
    ..Both direct and cortico-limbic pathways converge on the same anterior cingulate cortical and subcortical structures whose function may be to establish emotional valence and response priorities...
  3. ncbi Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input
    Max F K Happel
    Leibniz Institute for Neurobiology, D 39118 Magdeburg, Germany
    J Neurosci 30:11114-27. 2010
    ..The proposed conceptual framework allows integration of different and partly controversial anatomical and physiological models of spectral integration in the literature...
  4. ncbi Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    Ajay Dhaka
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:566-75. 2008
    ..We show that TRPM8 expression functionally associates with cold sensitivity in cultured DRGs, and provide the first glimpses of the unique anatomical architecture of cold fibers in vivo...
  5. ncbi Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats
    Ming Kui Zhong
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Exp Physiol 93:746-53. 2008
    ..These results indicate that inhibition or lesion of the PVN abolishes the CSAR, but excitation of the neurons in the PVN enhances the CSAR, suggesting that the PVN is an important component of the central neurocircuitry of the CSAR...
  6. ncbi Superoxide anions in the paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity in renovascular hypertensive rats
    Ying Han
    Dept of Physiology, Nanjing Medical Univ, Nanjing 210029, China
    J Appl Physiol (1985) 110:646-52. 2011
    ..These results indicate that superoxide anions in the PVN mediate the CSAR and the effects of ANG II in the PVN. Increased superoxide anions in the PVN contribute to the enhanced CSAR and sympathetic activity in renovascular hypertension...
  7. ncbi Thalamic input to distal apical dendrites in neocortical layer 1 is massive and highly convergent
    Pablo Rubio-Garrido
    Department of Anatomy and Neuroscience, School of Medicine, Autonoma University, Madrid, Spain
    Cereb Cortex 19:2380-95. 2009
    ..In addition, they are consistent with the notion that layer 1-projecting axons may be a robust anatomical substrate for extensive "feedback" interactions between cortical areas via the thalamus...
  8. ncbi Afferent-induced facilitation of primary motor cortex excitability in the region controlling hand muscles in humans
    H Devanne
    Neurophysiologie Clinique, CHRU Lille, Hopital Roger Salengro, Lille Cedex, France
    Eur J Neurosci 30:439-48. 2009
    ..We conclude that afferent-induced facilitation is a mechanism which probably involves muscle spindle afferents and should be considered when studying sensorimotor integration mechanisms in healthy and disease situations...
  9. pmc Bladder afferent signaling: recent findings
    Anthony Kanai
    Department of Medicine and Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Urol 183:1288-95. 2010
    ..The main goals are to define and control the signaling pathways by which afferent information is generated and conveyed to the central nervous system. We summarize recent research on bladder afferent mechanisms...
  10. pmc Neuronal basis for object location in the vibrissa scanning sensorimotor system
    David Kleinfeld
    Department of Physics and Section of Neurobiology, University of California, San Diego, La Jolla, CA 92093, USA
    Neuron 72:455-68. 2011
    ..Efferent signals in motor cortex report the range of the scan. Collectively, these signals allow the rodent to form a percept of object location...
  11. pmc Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice
    Albrecht Sigler
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, Brain Research Center, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 106:11759-64. 2009
    ..Given that redistribution occurs within an hour, the effect is likely to involve surviving accessory pathways and could potentially contribute to rapid behavioral compensation or direct future circuit rewiring...
  12. ncbi Dorsal root potentials and dorsal root reflexes: a double-edged sword
    W D Willis
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Exp Brain Res 124:395-421. 1999
    ..The conversion of an inhibitory process, presynaptic inhibition, to an excitatory one by DRRs can thus lead to pathological consequences...
  13. ncbi Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine
    H Pan
    Department of Anatomy, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Neurosci 20:3295-309. 2000
    ..Slow EPSPs are necessary for excitation to spread within the submucosal plexus. Because some second-order neurons contain also CGRP, primary afferent neurons may be multifunctional and also serve as interneurons...
  14. ncbi Evidence against cholera toxin B subunit as a reliable tracer for sprouting of primary afferents following peripheral nerve injury
    S A S Shehab
    Department of Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, PO Box 17666, Al Ain, United Arab Emirates
    Brain Res 964:218-27. 2003
    ....
  15. ncbi Role of extracellular signal-regulated kinase in synaptic transmission and plasticity of a nociceptive input on capsular central amygdaloid neurons in normal and acid-induced muscle pain mice
    Sin Jhong Cheng
    Institute of Zoology, National Taiwan University, Taipei 106, Taiwan
    J Neurosci 31:2258-70. 2011
    ..Since the CeAC plays an important role in the emotionality of pain, enhanced synaptic function of nociceptive (PBA) inputs onto CeAC neurons might partially account for the supraspinal mechanisms underlying central sensitization...
  16. pmc Central sensitization: a generator of pain hypersensitivity by central neural plasticity
    Alban Latremoliere
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    J Pain 10:895-926. 2009
    ..Instead, central sensitization produces pain hypersensitivity by changing the sensory response elicited by normal inputs, including those that usually evoke innocuous sensations...
  17. pmc Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats
    H Rheinallt Parri
    School of Life and Health Sciences, Aston Triangle, Aston University, Birmingham, UK
    Eur J Neurosci 32:29-40. 2010
    ..Ca(2+)](i) transients following stimulation of the sensory and/or corticothalamic excitatory afferent pathways. Cells of the other glial group, by contrast, stain positively for NG2, and are characterized by high input ..
  18. pmc Neuronal oscillations and multisensory interaction in primary auditory cortex
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Neuron 53:279-92. 2007
    ..The timing and laminar profile of the multisensory interactions in A1 indicate that nonspecific thalamic systems may play a key role in the effect...
  19. pmc Robust temporal coding in the trigeminal system
    Lauren M Jones
    Program in Neuroscience and Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 304:1986-9. 2004
    ..These predictions are significantly improved by integrating responses from neurons with opposite angular preferences...
  20. ncbi The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    A N Akopian
    Molecular Nociception Group, Department of Biology, Medawar Building, University College, London WC1E 6BT, UK
    Nat Neurosci 2:541-8. 1999
    ..These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects...
  21. ncbi Orthogonal coding of object location
    Per Magne Knutsen
    Department of Neurobiology, Weizmann Institute for Science, Rehovot 76100, Israel
    Trends Neurosci 32:101-9. 2009
    ..One advantage of such a same-neuron-different-codes scheme over the traditionally assumed same-code-different-neurons scheme is a reduction of code ambiguity that, in turn, simplifies decoding circuits...
  22. ncbi Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 56:300-8. 2006
    ....
  23. ncbi Reactive oxygen species in the paraventricular nucleus mediate the cardiac sympathetic afferent reflex in chronic heart failure rats
    Ying Han
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Eur J Heart Fail 9:967-73. 2007
    ..These results indicate that ROS in the PVN mediates the CSAR and the effect of angiotensin II in the PVN on the CSAR in both CHF and sham-operated rats. Increased ROS in the PVN are involved in the enhanced CSAR in CHF...
  24. ncbi Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
    ..These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions...
  25. pmc Texture coding in the rat whisker system: slip-stick versus differential resonance
    Jason Wolfe
    Department of Physics, University of California San Diego, La Jolla, California, United States of America
    PLoS Biol 6:e215. 2008
    ..These results suggest that texture is encoded not by differential resonant motion across whiskers, but by the magnitude and temporal pattern of slip-stick motion. These findings predict a temporal code for texture in neural spike trains...
  26. ncbi A common framework for perceptual learning
    Aaron R Seitz
    Department of Psychology, Boston University, 64 Cummington Street, Boston, MA 02215, USA
    Curr Opin Neurobiol 17:148-53. 2007
    ....
  27. pmc Magnetic field changes activate the trigeminal brainstem complex in a migratory bird
    Dominik Heyers
    Arbeitsgruppe Neurosensorik Animal Navigation, Institut für Biologie und Umweltwissenschaften, University of Oldenburg, D 26111 Oldenburg, Germany
    Proc Natl Acad Sci U S A 107:9394-9. 2010
    ..We therefore suggest that V1 transmits magnetic information to the brain in this migratory passerine bird...
  28. ncbi Visceral afferents directly activate catecholamine neurons in the solitary tract nucleus
    Suzanne M Appleyard
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239, USA
    J Neurosci 27:13292-302. 2007
    ..Thus, NTS CA neurons are directly driven by visceral afferents with output being modulated by presynaptic peptide receptors and postsynaptic potassium channels...
  29. pmc A rapamycin-sensitive signaling pathway is essential for the full expression of persistent pain states
    Sandrine M Géranton
    Department of Cell and Developmental Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 29:15017-27. 2009
    ....
  30. ncbi Cholinergic deafferentation of the entorhinal cortex in rats impairs encoding of novel but not familiar stimuli in a delayed nonmatch-to-sample task
    Jill McGaughy
    Department of Psychology Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 25:10273-81. 2005
    ..This indicates an important role for cholinergic innervation of the entorhinal cortex in working memory for novel stimuli...
  31. pmc Interdigitated paralemniscal and lemniscal pathways in the mouse barrel cortex
    Ingrid Bureau
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, United States of America
    PLoS Biol 4:e382. 2006
    ..L2 neurons received input from lemniscal L3 cells and paralemniscal L5A cells spread over multiple columns. Our data indicate that lemniscal and paralemniscal information is segregated into interdigitated cortical layers...
  32. pmc Primary afferent synapses on developing and adult Renshaw cells
    George Z Mentis
    Laboratory of Neural Control, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurosci 26:13297-310. 2006
    ..Similar synaptic weight shifts on interneurons may be involved in the maturation of motor reflexes and locomotor circuitry...
  33. ncbi Neural activity in barrel cortex underlying vibrissa-based object localization in mice
    Daniel H O'Connor
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 67:1048-61. 2010
    ..Approximately 13,000 spikes per activated barrel column were available to mice for decision making. Coding of object location in the barrel cortex is therefore highly redundant...
  34. ncbi Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action
    Hui Lin Pan
    Department of Anesthesiology, The Pennsylvania State University College of Medicine, The Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    J Neurosci 23:2911-9. 2003
    ..These data provide new insights into the potential mechanisms of postherpetic neuralgia...
  35. ncbi Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis
    L Y Qiao
    Department of Physiology, School of Medicine, Virginia Commonwealth University, Richmond, VA 23298 0551, USA
    Neurogastroenterol Motil 20:928-38. 2008
    ....
  36. ncbi Interactions between short latency afferent inhibition and long interval intracortical inhibition
    Kaviraja Udupa
    Division of Neurology, Department of Medicine, University of Toronto, Toronto, ON, Canada
    Exp Brain Res 199:177-83. 2009
    ..Both LICI and SAI decreased with increasing test MEP amplitude. Afferent stimulation that produced SAI decreased LICI. Thus, the present findings suggest that LICI and SAI have inhibitory interactions...
  37. ncbi Loss of short-latency afferent inhibition and emergence of afferent facilitation following neuromuscular electrical stimulation
    C S Mang
    Brain Behaviour Laboratory, Faculty of Medicine, Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada
    Neurosci Lett 529:80-5. 2012
    ..Maximising this excitatory effect on M1 circuits may help strengthen CS pathways and improve functional outcomes of NMES-based rehabilitation programs...
  38. ncbi Conditioning intensity-dependent interaction between short-latency interhemispheric inhibition and short-latency afferent inhibition
    Ryosuke Tsutsumi
    Dept of Neurology, Div of Neuroscience, Graduate School of Medicine, Univ of Tokyo, Tokyo, Japan
    J Neurophysiol 108:1130-7. 2012
    ..On the basis of these findings, we conclude that interneurons mediating SIHI and SAI have mutual, direct, and inhibitory interaction in a conditioning intensity-dependent manner...
  39. ncbi An electron microscopic examination of the corticospinal projection to the cervical spinal cord in the rat: lack of evidence for cortico-motoneuronal synapses
    H W Yang
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    Exp Brain Res 149:458-69. 2003
    ..The results confirm other lines of evidence suggesting that such connections are not present in the rat...
  40. ncbi Responses of infragranular neurons in the rat primary somatosensory cortex to forepaw and hindpaw tactile stimuli
    K A Moxon
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Neuroscience 156:1083-92. 2008
    ....
  41. ncbi Afferent fibers of the hypogastric nerves are involved in the facilitating effects of chemical bladder irritation in rats
    T Mitsui
    Department of Urology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    J Neurophysiol 86:2276-84. 2001
    ..These results suggest that capsaicin-sensitive bladder afferent fibers in the HGN, which travel through the rostral lumbar spinal cord, have a role in urinary frequency caused by chemical bladder irritation...
  42. ncbi Transcutaneous electrical nerve stimulation combined with task-related training improves lower limb functions in subjects with chronic stroke
    Shamay S M Ng
    Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
    Stroke 38:2953-9. 2007
    ....
  43. pmc Cystitis increases colorectal afferent sensitivity in the mouse
    Pablo Rodolfo Brumovsky
    Center for Pain Research, Departments of Anesthesiology, University of Pittsburgh, Pennsylvania, USA
    Am J Physiol Gastrointest Liver Physiol 297:G1250-8. 2009
    ..These data support a peripheral contribution to cross-organ sensitization of pelvic organs...
  44. ncbi The expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in neurochemically defined axonal populations in the rat spinal cord with emphasis on the dorsal horn
    A J Todd
    Spinal Cord Group, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Eur J Neurosci 17:13-27. 2003
    ..As all primary afferents are thought to be glutamatergic, this raises the possibility that unmyelinated afferents, most of which are nociceptors, express a different vesicular glutamate transporter...
  45. ncbi Differential postsynaptic compartments in the laterocapsular division of the central nucleus of amygdala for afferents from the parabrachial nucleus and the basolateral nucleus in the rat
    Yu Lin Dong
    Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, Japan
    J Comp Neurol 518:4771-91. 2010
    ..01). These results suggest that distinct synaptic impacts from PB- and BLA-CeC pathways contribute to the integration of nociceptive and polymodal information in the CeC...
  46. ncbi Cardiac sympathetic afferent reflexes in heart failure
    W Wang
    Department of Physiology and Biophysics, University of Nebraska College of Medicine, Omaha, NE 68198 4575, USA
    Heart Fail Rev 5:57-71. 2000
    ....
  47. ncbi GABA(B) receptors on vagal afferent pathways: peripheral and central inhibition
    E R Partosoedarso
    Nerve-Gut Research Laboratory, Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
    Am J Physiol Gastrointest Liver Physiol 280:G658-68. 2001
    To investigate GABA(B) receptors along vagal afferent pathways, we recorded from vagal afferents, medullary neurons, and vagal efferents in ferrets. Baclofen (7-14 micromol/kg i.v...
  48. ncbi Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization
    Elena E Ustinova
    Division of Gastroenterology, Hepatology, and Nutrition, Univ of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Am J Physiol Renal Physiol 290:F1478-87. 2006
    ..Interruption of the neural input to the bladder minimized this effect, suggesting a local afferent pathway from the colon. Thus, the overlap of CPP disorders may be a consequence of pelvic afferent cross-sensitization...
  49. pmc Interactions between short-interval intracortical inhibition and short-latency afferent inhibition in human motor cortex
    Henrik Alle
    Department of Neurology, Goethe University, Schleusenweg 2 16, 60528 Frankfurt am Main, Germany
    J Physiol 587:5163-76. 2009
    ..Furthermore, dominance of S1 over P is compatible with the notion that the SICI interneurons target the corticospinal neurons closer to their axon initial segment than the SAI interneurons...
  50. ncbi Bistability of cerebellar Purkinje cells modulated by sensory stimulation
    Yonatan Loewenstein
    Department of Neurobiology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Nat Neurosci 8:202-11. 2005
    ..Purkinje cell bistability may have a key role in the short-term processing and storage of sensory information in the cerebellar cortex...
  51. ncbi Effects of nitric oxide on the primary bladder afferent activities of the rat with and without intravesical acrolein treatment
    Naoki Aizawa
    Department of Urology, Faculty of Medicine, University of Antwerp, Antwerp, Belgium
    Eur Urol 59:264-71. 2011
    It has been suggested that nitric oxide (NO) affects the afferent pathways innervating the bladder. In addition, acrolein, a metabolite of cyclophosphamide, causes bladder hypersensitivity in rats.
  52. ncbi Parallel "pain" pathways arise from subpopulations of primary afferent nociceptor
    Joao M Braz
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA
    Neuron 47:787-93. 2005
    ..Our results indicate that parallel, perhaps independent pain pathways arise from different nociceptor classes and that motor as well as limbic targets predominate in the circuits that originate from the nonpeptide population...
  53. ncbi Angiotensin AT1 receptors in paraventricular nucleus contribute to sympathetic activation and enhanced cardiac sympathetic afferent reflex in renovascular hypertensive rats
    Ai Dong Chen
    Department of Physiology, Nanjing Medical University, Nanjing, China
    Exp Physiol 96:94-103. 2011
    ..These results indicate that the increased activity of AT(1) receptors in the PVN contributes to the enhanced CSAR and excessive sympathetic activation in renovascular hypertensive rats...
  54. ncbi Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways
    Kenneth Lamb
    Department of Pharmacology, University of Iowa, Iowa City, Iowa, USA
    Am J Physiol Gastrointest Liver Physiol 290:G451-7. 2006
    ..We conclude that cross talk between afferent visceral and somatic pathways may contribute to the coexistence of pain syndromes...
  55. pmc Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia
    Bai Yan Li
    Department of Biomedical Engineering, Indiana University Purdue University Indianapolis, Indianapolis, IN 46202, USA
    J Neurosci Methods 164:75-85. 2007
    ..Collectively, these indicators of afferent fiber type can be used to provide valuable insight concerning the relavence of isolated cellular observations to integrated afferent function of visceral organ systems...
  56. pmc Convergence of bladder and colon sensory innervation occurs at the primary afferent level
    Julie A Christianson
    Department of Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Pain 128:235-43. 2007
    ....
  57. ncbi Monosynaptic connections between pairs of spiny stellate cells in layer 4 and pyramidal cells in layer 5A indicate that lemniscal and paralemniscal afferent pathways converge in the infragranular somatosensory cortex
    Dirk Feldmeyer
    Zelluläre Neurobiologie, Institut fur Medizin, Forschungszentrum Julich, D 52425 Julich, Germany
    J Neurosci 25:3423-31. 2005
    ..These monosynaptic connections establish a monosynaptic coupling of the input to the cortex and its output, thereby effectively bypassing the supragranular layers...
  58. ncbi Psychophysical and physiological evidence for parallel afferent pathways mediating the sensation of itch
    Lisa M Johanek
    Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland 21287, USA
    J Neurosci 27:7490-7. 2007
    ..Cowhage may be useful to investigate the neural pathway mediating nonhistaminergic itch...
  59. ncbi Information rate and spike-timing precision of proprioceptive afferents
    Ralph A DiCaprio
    Neuroscience Program, Department of Biological Sciences, Ohio University, Athens, OH 45701, USA
    J Neurophysiol 98:1706-17. 2007
    ..1 ms, indicating that intrinsic membrane properties, spike generation, and mechanotransduction mechanisms are the major sources of timing jitter in this system...
  60. ncbi Rapid modulation of GABA in sensorimotor cortex induced by acute deafferentation
    Lucien M Levy
    Neuroimaging Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Building 10, 5D20, Bethesda, MD 20892, USA
    Ann Neurol 52:755-61. 2002
    ..Reduction of brain GABA can play a pivotal role in regulating the extent of rapid cortical reorganization after lesions or changes in sensory input...
  61. pmc Whisker-mediated texture discrimination
    Mathew E Diamond
    Cognitive Neuroscience Sector, International School for Advanced Studies, Trieste, Italy
    PLoS Biol 6:e220. 2008
  62. ncbi 'Where' and 'what' in the whisker sensorimotor system
    Mathew E Diamond
    Cognitive Neuroscience Sector, International School for Advanced Studies SISSA, 34014 Trieste, Italy
    Nat Rev Neurosci 9:601-12. 2008
    ..Future research may elucidate this and show how the transformation of one representation to another is achieved...
  63. ncbi Active sensation: insights from the rodent vibrissa sensorimotor system
    David Kleinfeld
    Department of Physics, University of California at San Diego, 9500 Gilman Drive 0374, La Jolla, 92093, USA
    Curr Opin Neurobiol 16:435-44. 2006
    ..Recent in vivo and in vitro electrophysiological measurements provide insight into the algorithms and mechanisms that underlie these behavioral-based computations...
  64. ncbi Layer-specific somatosensory cortical activation during active tactile discrimination
    David J Krupa
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 304:1989-92. 2004
    ..Instead, these results suggest that top-down influences during active discrimination may alter the overall functional nature of SI as well as layer-specific mechanisms of tactile processing...
  65. ncbi Central post-stroke pain: clinical characteristics, pathophysiology, and management
    Henriette Klit
    Danish Pain Research Center, Aarhus University Hospital, Denmark
    Lancet Neurol 8:857-68. 2009
    ..Although treatment of CPSP is difficult, the most effective approaches are those that target the increased neuronal hyperexcitability...
  66. ncbi Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons
    Qian Quan Sun
    Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:1219-30. 2006
    ..The ready activation of FS cells by TC inputs, coupled with powerful feedforward inhibition from these neurons, would profoundly influence sensory processing and constrain runaway excitation in vivo...
  67. pmc Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
    Dirk Feldmeyer
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 538:803-22. 2002
    ....
  68. ncbi On the origins of the sensory output from the bladder: the concept of afferent noise
    James I Gillespie
    The Uro physiology Research Group, The Medical School, The University, Newcastle upon Tyne, UK
    BJU Int 103:1324-33. 2009
    ..The emerging picture is complex, but this complexity must not be negated or oversimplified. It must be embraced and incorporated it into thinking when designing experiments, analysing data, diagnosing patients and evaluating treatment...
  69. ncbi Thalamocortical [correction of Thalamcortical] optimization of tactile processing according to behavioral state
    Miguel A L Nicolelis
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Neurosci 5:517-23. 2002
    ....
  70. pmc Primary afferent activation of thermosensitive TRPV1 triggers asynchronous glutamate release at central neurons
    James H Peters
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR 97239, USA
    Neuron 65:657-69. 2010
    ..This activity-dependent TPRV1-mediated facilitation is a form of synaptic plasticity that brings a unique central integrative feature to the CNS and autonomic regulation...
  71. ncbi Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract
    Sean M Ward
    Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, Nevada 89557, USA
    J Comp Neurol 465:121-35. 2003
    ..VR1-like fibers appear to be predominantly spinal in origin, but a few vagal VR1-like fibers exist in the stomach...
  72. ncbi Information processing streams in rodent barrel cortex: the differential functions of barrel and septal circuits
    Kevin D Alloway
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033 2255, USA
    Cereb Cortex 18:979-89. 2008
    ..Separate afferent pathways convey somatosensory information to the barrels and septa that represent the input stages for 2 partially ..
  73. ncbi Purinergic and vanilloid receptor activation releases glutamate from separate cranial afferent terminals in nucleus tractus solitarius
    Young Ho Jin
    Department of Physiology and Pharmacology, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurosci 24:4709-17. 2004
    ..Together, results are consistent with segregation of glutamatergic terminals into either P2X sensitive or VR1 sensitive that correspondingly identify myelinated and unmyelinated afferent pathways at the NTS.
  74. pmc Endothelin-1 in paraventricular nucleus modulates cardiac sympathetic afferent reflex and sympathetic activity in rats
    Ai Dong Chen
    Department of Physiology, Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e40748. 2012
    ..The present study is designed to determine whether endothelin-1 (ET-1) in the PVN modulates the CSAR and sympathetic activity, and whether superoxide anions are involved in modulating the effects of ET-1 in the PVN in rats...
  75. pmc Subtypes of vagal afferent C-fibres in guinea-pig lungs
    B J Undem
    Johns Hopkins School of Medicine, and University, Baltimore, MD, USA
    J Physiol 556:905-17. 2004
    ..The data support the hypothesis that both neural crest-derived neurones (jugular ganglia) and placode-derived neurones (nodose ganglia) project C-fibres in the vagus, and that these two C-fibre populations represent distinct phenotypes...
  76. ncbi Cutaneomotor integration in humans is somatotopically organized at various levels of the nervous system and is task dependent
    J Classen
    Zentrum fur Nervenheilkunde, Neurologische Klinik, Universitat Rostock, Germany
    Exp Brain Res 130:48-59. 2000
    ..Together, our findings suggest that somatotopy of input-output relationships is implemented at both a spinal and a cortical level in the human central nervous system and may also depend on the motor task involved...
  77. pmc Sympatho-renal axis in chronic disease
    Paul A Sobotka
    The Ohio State University, Columbus, OH, USA
    Clin Res Cardiol 100:1049-57. 2011
    ....
  78. ncbi Pregabalin, S-(+)-3-isobutylgaba, activates the descending noradrenergic system to alleviate neuropathic pain in the mouse partial sciatic nerve ligation model
    Yuichi Takeuchi
    Laboratory of CNS Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Nagoya 467 8603, Japan
    Neuropharmacology 53:842-53. 2007
    ..Together, these results indicate that pregabalin supraspinally activates the descending noradrenergic pain inhibitory system coupled with spinal alpha(2)-adrenoceptors to ameliorate neuropathic pain...
  79. ncbi Afferent mechanisms underlying stimulation modality-related modulation of acupuncture-related cardiovascular responses
    Wei Zhou
    Department of Medicine, College of Medicine, University of California, Irvine, CA 92697, USA
    J Appl Physiol (1985) 98:872-80. 2005
    ..The similarity of the responses to EA and MA and the lack of cardiovascular response to high-frequency EA appear to be largely a function of somatic afferent responses...
  80. ncbi Dendroarchitecture of relay cells in thalamic barreloids: a substrate for cross-whisker modulation
    Caroline Varga
    Centre de Recherche, Université Laval Robert Giffard, Quebec G1J 2G3, Canada
    J Neurosci 22:6186-94. 2002
    ..Because relay cell responses are direction sensitive, maximal modulation would occur if dendritic field orientation relates to the direction selectivity of responses...
  81. ncbi Reciprocal bidirectional plasticity of parallel fiber receptive fields in cerebellar Purkinje cells and their afferent interneurons
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, Lund University, The Biomedical Center F10, Tornavagen 10, SE 221 84, Sweden
    Neuron 34:797-806. 2002
    ..These properties, and the fact the mossy fiber receptive fields were unchanged, suggest that the receptive field changes were due to bidirectional PF synaptic plasticity in Purkinje cells and interneurons...
  82. ncbi Neural coding and contextual influences in the whisker system
    Rasmus S Petersen
    Faculty of Life Sciences, University of Manchester, Manchester, UK
    Biol Cybern 100:427-46. 2009
    ..Future work on neural coding in cortex will need to consider new findings that responses are highly dependent on context, including behavioural and internal states...
  83. ncbi Myelinated and unmyelinated primary afferent axons form contacts with cholinergic interneurons in the spinal dorsal horn
    M J Olave
    Spinal Cord Group, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, UK
    Exp Brain Res 145:448-56. 2002
    ..Cholinergic interneurons are likely to be components of an inhibitory feedback pathway that is monosynaptically activated by primary afferents...
  84. ncbi Visceral afferent pathways and functional brain imaging
    Stuart W G Derbyshire
    Department of Anesthesiology, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    ScientificWorldJournal 3:1065-80. 2003
    ..Future use of functional imaging to examine IBS and other functional disorders will be more likely to succeed by describing clear theoretical and clinical endpoints...
  85. pmc Gastric relaxation induced by hyperglycemia is mediated by vagal afferent pathways in the rat
    Shi Yi Zhou
    Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Physiol Gastrointest Liver Physiol 294:G1158-64. 2008
    ..of glucose-sensing neurons in the nodose ganglia led us to hypothesize that hyperglycemia acts through vagal afferent pathways to inhibit gastric motility...
  86. ncbi Two psychophysical channels of whisker deflection in rats align with two neuronal classes of primary afferents
    Maik C Stüttgen
    Abteilung für Kognitive Neurologie, Hertie Institut für Klinische Hirnforschung, Universitat Tubingen, 72076 Tubingen, Germany
    J Neurosci 26:7933-41. 2006
    ..This suggests that detection performance in both channels is based on the assessment of very few spikes in their corresponding groups of primary afferents...
  87. ncbi Expression of c-fos-like immunoreactivity in the feline brainstem in response to isometric muscle contraction and baroreceptor reflex changes in arterial pressure
    C A Williams
    Department of Physiology, The James H Quillen College of Medicine, East Tennessee State University, Johnson City 37614 0576, USA
    Brain Res 852:424-35. 2000
    ..These results indicate that the exercise pressor reflex and baroreflex activate similar, but not completely identical, sites in the brainstem...
  88. ncbi Centrifugal regulation of task-relevant somatosensory signals to trigger a voluntary movement
    Tetsuo Kida
    Department of Integrative Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki, 444 8585, Japan
    Exp Brain Res 169:289-301. 2006
    ..The latter activities may be associated with sensory gain regulation related to directing attention to body parts involved in the action...
  89. ncbi Non-invasive measurement of vagus activity in the brainstem - a methodological progress towards earlier diagnosis of dementias?
    T Polak
    Laboratory for Psychophysiology and Functional Imaging, Department of Psychiatry and Psychotherapy, Julius Maximilians University, Wurzburg, Germany
    J Neural Transm 114:613-9. 2007
    ..05). Future large scale studies - also including preclinical stages of AD - have to assess the value of this non-invasive, fast and cheap method in the early diagnosis of neurodegenerative disorders...
  90. ncbi Neural feedback for instantaneous spatiotemporal modulation of afferent pathways in bi-directional brain-machine interfaces
    Jianbo Liu
    Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48823, USA
    IEEE Trans Neural Syst Rehabil Eng 19:521-33. 2011
    ..Our results suggest that neural feedback could be an effective method to facilitate the delivery of information to the cortex to substitute lost sensory inputs in cortically controlled BMIs...
  91. pmc Contribution of afferent pathways to nerve injury-induced spontaneous pain and evoked hypersensitivity
    Tamara King
    Department of Pharmacology, College of Medicine, University of Arizona, Tucson, AZ 95724, USA
    Pain 152:1997-2005. 2011
    ....
  92. pmc Exuberant thalamocortical axon arborization in cortex-specific NMDAR1 knockout mice
    Li Jen Lee
    Department of Cell Biology and Anatomy, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Comp Neurol 485:280-92. 2005
    ..Given that thalamic NMDARs are spared in CxNR1KO mice, the present results show that postsynaptic NMDARs play an important role in refinement of presynaptic afferent arbors and whisker-specific patterning in the developing barrel cortex...
  93. ncbi Researching bladder afferents-determining the effects of β(3) -adrenergic receptor agonists and botulinum toxin type-A
    Anthony Kanai
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Neurourol Urodyn 30:684-91. 2011
    ..This work is the result from 'Think Tank' presentations, and the lengthy discussions that followed, at the 2010 International Consultation on Incontinence Research Society meeting in Bristol, UK...
  94. pmc Effects of cholinergic deafferentation of the rhinal cortex on visual recognition memory in monkeys
    Janita Turchi
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2158-61. 2005
    ....
  95. ncbi Role of paraventricular nucleus in the cardiogenic sympathetic reflex in rats
    Matthew R Zahner
    Department of Anesthesiology, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 288:R420-6. 2005
    ..However, ionotropic glutamate receptors in the PVN are not directly involved in this reflex response...
  96. ncbi Short latency afferent inhibition and facilitation in patients with writer's cramp
    Kirn R Kessler
    Motor Cortex Laboratory, Department of Neurology, J W Goethe University, Frankfurt Main, Germany
    Mov Disord 20:238-42. 2005
    ..These findings suggest that somatosensory short-latency inhibitory input into the primary motor cortex is normal in WC, whereas a later excitatory input, which very likely reflects the long-latency reflex II, is exaggerated...
  97. ncbi Central pathways of pulmonary and lower airway vagal afferents
    Leszek Kubin
    Dept of Physiology M211, Feinberg School of Medicine, Northwestern Univ, 303 E Chicago Ave, Chicago, IL 60611 3008, USA
    J Appl Physiol (1985) 101:618-27. 2006
    ....
  98. ncbi Two types of afferent terminals innervate cochlear inner hair cells in C57BL/6J mice
    Howard W Francis
    Department of Otolaryngology Head and Neck Surgery, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Brain Res 1016:182-94. 2004
    ..In many cases, the double membrane was continuous with the outer terminal membrane as if produced by an invagination. We still must determine the generality of these observations with respect to other mouse strains...
  99. ncbi Chronic suppression of activity in barrel field cortex downregulates sensory responses in contralateral barrel field cortex
    Lu Li
    Dept of Psychology, Vanderbilt University, Nashville, TN 37203, USA
    J Neurophysiol 94:3342-56. 2005
    ..Bilateral neurological impairments have been described after unilateral stroke lesions in the clinical literature...
  100. pmc Differential synaptology of vGluT2-containing thalamostriatal afferents between the patch and matrix compartments in rats
    Dinesh V Raju
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 499:231-43. 2006
    ..These observations pave the way for understanding differential regulatory mechanisms of striatal outflow from the patch and matrix compartments by thalamostriatal afferents...
  101. ncbi Superoxide anions modulate the effects of angiotensin-(1-7) in the rostral ventrolateral medulla on cardiac sympathetic afferent reflex and sympathetic activity in rats
    P Li
    Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 210029, China
    Neuroscience 223:388-98. 2012
    ..The enzyme of NAD(P)H oxidase is a major source of the superoxide anions that modulate the effects of Ang-(1-7) in the RVLM...

Research Grants63

  1. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..concerted integration of the intrinsic properties of thalamic neurons, synaptic organization, activity of afferent pathways, and impinging influence of neuromodulators...
  2. Gender differences in aortic baroreceptor function and neural integration
    John H Schild; Fiscal Year: 2013
    ..different reflex control of heart rate and blood pressure evoked by these neuroanatomically distinct afferent pathways. The first aim examines gender-related differences in rat aortic BR afferents...
  3. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..concerted integration of the intrinsic properties of thalamic neurons, synaptic organization, activity of afferent pathways, and impinging influence of neuromodulators...
  4. Pharmacology of Intravesical Antisense Based Therapy for Over Active Bladder
    Naoki Yoshimura; Fiscal Year: 2013
    ..released from the urothelium during stretch can activate muscarinic receptors, leading to modulation of afferent pathways during the micturition reflex, and that increased ACh levels in the bladder can induce OAB mediated by the ..
  5. Chemosensing in the Gastrointestinal Tract
    Catia Sternini; Fiscal Year: 2010
    ..Aim 1 will determine 1a) the effects and site of action along the gut of intraluminal T2R agonists on vagal afferent pathways using c-fos as marker of neuronal activity, and the role of CCK and PYY, peptides that affect GI function ..
  6. Cross-sensitization in the pelvis and neurogenic bladder
    Anna P Malykhina; Fiscal Year: 2012
    ..Recent studies demonstrated the role of sensory afferent pathways in pelvic organ cross-sensitization, however, our understanding of the underlying mechanisms is still ..
  7. High Fat Feeding Promotes Malfunction of the Nodose Ganglia
    Chung Owyang; Fiscal Year: 2013
    ..and humans fed HFDs exhibit reduced sensitivity to a number of satiety signals known to act via the vagal afferent pathways. Our preliminary studies indicate that these abnormalities may be prevented by blockade of Toll-like ..
  8. Glucan Particles as a Vaccine Platform for Protective Immunity
    STUART MICHAEL LEVITZ; Fiscal Year: 2013
    ..Aim 1 is to decipher the afferent pathways stimulated by GPs that shape T cell and antibody responses...
  9. Spinal Cord Injury, Plasticity and Transplant Mediated Repair
    John D Houle; Fiscal Year: 2013
    ..Project 4 will use spinalized cats to test whether transplant-derived neurotrophins modify excitability of afferent pathways during locomotion and whether locomotor circuitry can be re-engaged in a chronic injury paradigm...
  10. Bladder Nociception: function/central projection of Sympathetic Afferent Pathway
    William C DeGroat; Fiscal Year: 2013
    ..destroyed sacral spinal cord or transected sacral spinal roots, indicating an important role of sympathetic afferent pathways. In this grant application we will focus our studies on the sympathetic afferent pathway to close the gap ..
  11. Stress-induced alterations in amygdala-LC interactions
    Anthony A Grace; Fiscal Year: 2012
    ..and suppression of DA system responsivity regulated in a VTA regionally-specific manner by specific afferent pathways. This will be done along 4 aims: 1) Test how each stressor affects DA neuron activity and amphetamine-..
  12. Modulation of Developing Spinal Nociceptive Circuits by Sensory Input
    Mark Baccei; Fiscal Year: 2010
    ..Unfortunately, nothing is currently known about how the level of activity in primary sensory afferent pathways influences synaptic function in developing nociceptive circuits...
  13. Engrailed genes and cerebellum morphology, spatial gene expression and circuitry
    Alexandra L Joyner; Fiscal Year: 2013
    ..Engrailed (En) mutants display both morphological defects in the cerebellum and topographic disruptions of afferent pathways. A better understanding of how En1/2 regulate cerebellum development should therefore provide insight into ..
  14. Development of Neuronal Circuits in the Auditory Systems
    Karl Kandler; Fiscal Year: 2013
    ..Previous studies on the development of the two major afferent pathways to the LSO, the excitatory pathway from the cochlear nucleus (CN) and the inhibitory pathway from the medial ..
  15. Posture and Orientation in Older Adults and Post-Stroke
    EMILY KESHNER; Fiscal Year: 2009
    ..selection of control pathways is determined by the task as well as further define response properties of the afferent pathways. Segmental and muscle response strategies will be examined through kinematic measures including center of ..
  16. CHOLECYSTOKININ--ROLE IN POSTPRANDIAL GASTRIC MOTILITY
    Helen Raybould; Fiscal Year: 1993
    ..In particular, the role of visceral afferent pathways in mediating changes in gastroduodenal motility induced by CCK and duodenal stimulants will be studied...
  17. Opioid Sensitive GABA inputs to the Ventral Midbrain
    John T Williams; Fiscal Year: 2013
    ..Each of these afferent pathways can now be manipulated selectively with the use of optogenetic tools such that a comprehensive picture of ..
  18. ACTIVITY OF VISCERAL & NOCICEPTIVE TRIGEMINAL NEURONS
    Andrew Strassman; Fiscal Year: 1992
    ..II. Determine the degree of convergence from multiple visceral and somatic afferent pathways onto individual trigeminovascular neurons...
  19. IRRITATION INDUCED PLASTICITY OF MICTURITION PATHWAYS
    MARGARET VIZZARD; Fiscal Year: 2000
    ..accompany IC may be mediated by at least three factors: (1) changes in the properties of peripheral bladder afferent pathways such that bladder afferent neurons respond in an exaggerated manner to normally innocuous stimuli, (2) ..
  20. Interneuronal mechanisms for the control of walking
    Jianguo Cheng; Fiscal Year: 2009
    ..the generation of locomotor-like activity, and to determine the pattern of synaptic projections from sensory afferent pathways to these interneurons...
  21. The Dorsomedial Hypothalamus and Responses to Stress
    JOSEPH DIMICCO; Fiscal Year: 2005
    ..Thus, distinct afferent pathways may be responsible for mobilizing the same hypothalamic effector systems in response to interoceptive (also ..
  22. Kainate Receptors on Hippocampal Interneurons
    Matthew Frerking; Fiscal Year: 2007
    ..calcium-permeable and can initiate calcium-dependent signaling; (b) that KARs are segregated to different afferent pathways than AMPA receptors; (c) that KARs allow interneurons to perform temporal integration at low afferent firing ..
  23. Proteomic Characterization of IC Bladder
    Pradeep Tyagi; Fiscal Year: 2006
    ..Factor (NGF), nitric oxide (NO) and proinflammatory mediators, have been shown to exert an effect in bladder afferent pathways that could be related to frequent voiding and nociceptive responses in chronic cystitis...
  24. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
    ..that stimulation of brain NK3 receptors activates (based on c-Fos expression) neurons in gustatory and vagal afferent pathways. The goals of the present proposal are to determine the sensory and neuroanatomical mechanisms by which NK3 ..
  25. AUTONOMIC NERVOUS CONTROL OF ORGANS
    Masahito Kawatani; Fiscal Year: 1990
    ..of the reproductive system, (2) identification of the segmental distribution and central projections of afferent pathways to the organs, (3) an analysis of putative neurotransmitters in afferent and efferent pathways, (4) study of ..
  26. OSMOTIC MODULATION OF HYPOTHALAMIC STEROID FEEDBACK
    THOMAS SHERMAN; Fiscal Year: 2001
    ..Within Aim 1, studies propose to examine the synaptic pharmacology and osmotic afferent pathways involved in the hypoosmolar induction of glucocorticoid receptor expression...
  27. Role of vagal nerves in hyperpnea
    Jerry Yu; Fiscal Year: 2006
    ..identify the structure, mechanical and chemical properties of the responsible endings and to identify their afferent pathways. Phrenic nerve activity and intraluminal pressure in the trachea will be recorded for assessing respiration...
  28. ESTROGEN MODULATES CARDIAC REFLEX CONTROL OF VEINS
    Douglas Martin; Fiscal Year: 1999
    ..Studies in dogs suggest that cardiac vagal afferent pathways cause venodilation and a reduction in cardiac filling...
  29. ENDOGENOUS OPIATES IN THE REGULATION OF VASOPRESSIN
    Gary Robertson; Fiscal Year: 1992
    ..the proposed studies will test the hypothesis that opioid interneurons are an integral part of the afferent pathways which mediates the effect of blood volume on vasopressin secretion...
  30. OLFACTORY CONTROL OF A SIMPLE MOTOR SYSTEM
    JOHN HILDEBRAND; Fiscal Year: 1992
    ..In favorable invertebrate preparations, the sensory afferent pathways and the neural elements that govern stereotyped behaviors are accessible to cellular study...
  31. REGULATION OF FED INTESTINAL MOTILITY BY FAT
    Henry Lin; Fiscal Year: 2000
    ..endocrine cell in contact with the lumen may serve as a "taste bud" for the small intestine and act on the afferent pathways by releasing a peptide product...
  32. SPINAL INTERNEURONS CONTROLLING VOLUNTARY LIMB MOVEMENT
    Steve Perlmutter; Fiscal Year: 2001
    ..by spinal interneurons and, if so, how are these interneurons selectively recruited by descending and afferent pathways? The activity of pairs of interneurons in the lower cervical spinal cord of monkeys will be recorded as they ..
  33. ANATOMICAL BASIS OF OLFACTORY DISCRIMINATION
    Burton Slotnick; Fiscal Year: 1980
    ..threshold, intensity difference threshold and 2-odor discrimination will be evaluated after sectioning afferent pathways from the olfactory bulb...
  34. REGULATION OF STRIATAL NEURONS BY NMDA RECEPTOR SUBTYPES
    KRISTEN KEEFE; Fiscal Year: 2006
    ..regions indicate that different NMDA receptor subtypes can be targeted to synapses associated with distinct afferent pathways within the same neuron...
  35. Assessment of Altered Function in Diabetic Bladder
    Firouz Daneshgari; Fiscal Year: 2005
    ..test the feasibility of use of TUR-ACT Device to assess autonomic nerve conduction threshold of small fiber afferent pathways in the bladder of the diabetic and normal rats; and b) test the possible change of the CPT value in normal ..
  36. MECHANISMS OF STIMULANT ACTION IN NUCLEUS ACCUMBENS
    Rosemarie Booze; Fiscal Year: 1993
    ..2) To examine whether lesions of the allocortical afferent pathways to the nucleus accumbens affect the D-2 dopamine receptor response to cocaine...
  37. Physical and Pharmacological Effects on Movement in SCI
    THOMAS HORNBY; Fiscal Year: 2006
    ..We expect the monoaminergic agents to depress excitability of selected afferent pathways, but enhance circuitry responsible for volitional motor output and locomotion, thereby expediting the ..
  38. DEVELOPMENTAL SHAPING OF CEREBELLAR AFFERENT TOPOGRAPHY
    DANIEL TOLBERT; Fiscal Year: 1992
    ..organized olivocerebellar (IO-CB) projections establish a framework to guide later developing afferent pathways to appropriate areas of termination...
  39. SYNAPTIC PLASTICITY OF HYPOTHALAMIC NEURONS--ESTROGENS
    OLINE RONNEKLEIV; Fiscal Year: 2002
    ..Focal electrical stimulation of afferent pathways into the POA will be done to identify inhibitory and excitatory synaptic currents using whole-cell patch ..
  40. Opioid Regulation of cAMP in the Vestibular Epithelia
    Paul Popper; Fiscal Year: 2006
    ..These studies will provide a model for determining the role of the efferent and afferent pathways during vestibular compensation, after vestibular injury, or during specific vestibular disorders such as ..
  41. DUKE-VA CENTER FOR CEREBROVASCULAR RESEARCH
    J Victor Nadler; Fiscal Year: 1991
    ..A final group of projects focusses on neuronal function of the senory cortex after injury to primary afferent pathways, on cell-cell interactions, and on the membrane biochemistry of cultured neurons...
  42. PHYSIOLOGY OF CNS BIOGENIC AMINES AND SEIZURE DISORDERS
    Barry Waterhouse; Fiscal Year: 1991
    ..A combination of microiontophoretic techniques, stimulation of biogenic amine and synaptic afferent pathways and computer assisted analysis of peri-event histograms will be employed to quantitatively assess the ..
  43. Peripheral Nerve Stimulation for Bladder Emptying
    JOSEPH BOGGS; Fiscal Year: 2006
    ..feasibility of eliciting bladder contractions to expel stored urine by electrical stimulation of urethral afferent pathways in the pudendal nerve (PN) in persons with SCI...
  44. MECHANISM OF PAIN IN PATIENTS WITH FIBROMYALGIA SYNDROME
    Roland Staud; Fiscal Year: 2008
    ..In addition, our findings may contribute to the understanding of pain mechanisms related to other chronic pain disorders. ..
  45. Peripheral and Central Mechanism of Pain in Patients with Fibromyalgia
    ROLAND M STAUD; Fiscal Year: 2010
    ..Either way, we will provide evidence that will characterize the role of local anesthesia, placebo analgesia, or both. Thus patients with FM and other similar pain syndromes may strongly benefit from the results of our study. ..
  46. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  47. PURDUE INTEGRATIVE NEUROSCIENCE PROGRAM
    TERRY POWLEY; Fiscal Year: 2002
    ..Students trained in the interdisciplinary Purdue Integrative Neuroscience program will make substantial contributions to mental health research and its applications in the next century. ..
  48. AUTONOMIC CONTROL OF BODY WEIGHT AND FEEDING
    TERRY POWLEY; Fiscal Year: 2006
    ..abstract_text> ..
  49. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  50. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..B4, which can theoretically suppress afferent transmission via IB4-binding, non-peptidergic C-fiber afferent pathways. This will allow us to identify the functional role of non-peptidergic C-fiber afferents in pain conditions ..
  51. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  52. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  53. AUTONOMIC REGULATION OF AIRWAY SMOOTH MUSCLE TONE
    BRENDAN CANNING; Fiscal Year: 2001
    ..It is anticipated that this information will improve our understanding of the role of the autonomic innervation of the healthy and diseased lung. ..
  54. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
    ..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..
  55. KININS AS MEDIATORS OF HUMAN REACTIONS
    BRENDAN CANNING; Fiscal Year: 2003
    ..These rigorous studies will not only clarify the role of BK in airway diseases, but will also have broader relevance by providing new and important insights into how neural function is altered in asthma and rhinitis. ..
  56. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
    ..These studies will advance our understanding of the anatomical substrates for pain sensation in the primate thalamus. ..
  57. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    ..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
  58. Nitric oxide in bladder neural-epithelial signaling
    Lori Birder; Fiscal Year: 2005
    ..Elucidation of mechanisms impacting on urothelial function may provide insights into the pathology of bladder dysfunction. ..
  59. MAST CELL NERVE INTERACTIONS IN AIRWAYS
    Bradley J Undem; Fiscal Year: 2010
    ..The results may also shed new light on the complex pathophysiology of allergic airway diseases, i.e., asthma, and ultimately suggest new therapeutic strategies for treatment of these complex disorders. ..
  60. SYNAPTIC CONNECTIONS OF SPINAL CORD NEURONS
    William Willis; Fiscal Year: 2007
    ..Preliminary evidence supports the feasibility of the work and suggests that the results could lead to a number of new targets for improvements in pain therapy. ..
  61. Glucose-Sensing and Intestinal Feedback Inhibition
    Helen Raybould; Fiscal Year: 2007
    ..A greater understanding of these sensory mechanisms will help in understanding the pathophysiology of these diseases. ..
  62. Reflexes and Supraesophageal Consequences of Reflux Disease
    Brendan J Canning; Fiscal Year: 2010
    ..This research may also help identify novel therapeutic strategies for treating both GERD and chronic cough. ..
  63. MECHANISM UNDERLYING NGF-INDUCED CORTICAL PLASTICITY
    RON FROSTIG; Fiscal Year: 2003
    ..abstract_text> ..