- Neural tissue engineering: a self-organizing collagen guidance conduit
James B Phillips
University College London, Tissue Repair and Engineering Centre, Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
Tissue Eng 11:1611-7. 2005
..Neural regeneration through this device was significantly greater than in controls, demonstrating that this system has potential both as a simple robust clinical implant and as a three-dimensional engineered tissue model...
- Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineering
Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
PLoS ONE 8:e57157. 2013
..this study demonstrate that aligned PHB/PHBV electrospun nanofibers could find potential use as scaffolds for nerve tissue engineering applications and that the presence of type I collagen in the nanofibers improves cell ..
- Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering
Islamic Azad University, Najafabad Branch, Isfahan, Iran
J Tissue Eng Regen Med 5:e17-35. 2011
..makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering...
- Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering
NUS Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore
Biomaterials 29:4532-9. 2008
b>Nerve tissue engineering is one of the most promising methods to restore nerve systems in human health care. Scaffold design has pivotal role in nerve tissue engineering...
- Electrospun PLGA-silk fibroin-collagen nanofibrous scaffolds for nerve tissue engineering
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
In Vitro Cell Dev Biol Anim 47:234-40. 2011
..have been performed to examine the PLGA-silk fibroin-collagen (PLGA-SF-COL) biocomposite fiber matrices for nerve tissue engineering...
- Photofabricated gelatin-based nerve conduits: nerve tissue regeneration potentials
Division of Biomedical Engineering, Graduate School of Dental Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Cell Transplant 13:549-64. 2004
..Prior to study on nerve tissue engineering using Schwann cells or nerve stem cells, the effectiveness of photofabricated scaffolds based on ..
- Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering
Molamma P Prabhakaran
Nanoscience and Nanotechnology Initiative, Division of Bioengineering, 9 Engineering Drive 1, National University of Singapore, Singapore 117576, Singapore
Biomaterials 30:4996-5003. 2009
..Our studies on the differentiation of MSCs to neuronal cells on nanofibrous scaffolds suggest their potential application towards nerve regeneration...
- Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves
Department of Otolaryngology, Head and Neck Surgery, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv, 64239, Israel
J Natl Cancer Inst 102:107-18. 2010
..For these tumors, nerves may provide a conduit for local cancer progression into the central nervous system. Although neural invasion is associated with poor outcome, the mechanism that triggers it is unknown...
- Mass spectrometric-based proteomic analysis of amyloid neuropathy type in nerve tissue
Christopher J Klein
Department of Neurology Peripheral Nerve Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
Arch Neurol 68:195-9. 2011
..To determine the specific type of amyloid from nerve biopsies using laser microdissection (LMD) and mass spectrometric (MS)-based proteomic analysis...
- Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP
Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, U S A
J Neurochem 68:1804-11. 1997
..However, in the absence of ADP, the nerve tissue-specific GDH showed only 5% of its maximal activity, compared with approximately 40% showed by the housekeeping ..
- Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray
Jian Jun Zhao
Department of Genetics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Childs Nerv Syst 22:1419-25. 2006
..Our objective was to develop an oligonucleotide DNA microarray (OMA) for genome-wide microRNA profiling and use this method to find miRNAs, which control organic development especially for nervous system...
- Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function
Department of Neurology, University of Crete, School of Health Sciences, Section of Medicine, Heraklion, Crete, Greece
J Neurochem 75:1862-9. 2000
..dehydrogenase (GDH), an enzyme central to the metabolism of glutamate, is known to exist in housekeeping and nerve tissue-specific isoforms encoded by the GLUD1 and GLUD2 genes, respectively...
- Porous chitosan tubular scaffolds with knitted outer wall and controllable inner structure for nerve tissue engineering
Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
J Biomed Mater Res A 79:36-46. 2006
..tubular scaffolds with desirable mechanical properties and controllable inner structure from chitosan, for nerve tissue engineering...
- Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro
Division of Bio Information Engineering, Faculty of Engineering, Toyama University, 3190 Gofuku, Toyama 930 8555, Japan
Peptides 26:471-81. 2005
- Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps
B A Harley
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Mass, USA
Cells Tissues Organs 176:153-65. 2004
..The data show the presence of a hitherto unreported optimal chamber degradation rate that leads to regenerated nerves of maximum quality...
- Functional, morphological and biomolecular assessment of posttraumatic neuro-muscular recovery in the rat forelimb model
Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Hospitale San Luigi, Torino, Italy
Acta Neurochir Suppl 100:173-7. 2007
..Furthermore, since the forelimb model is less compromising for the animal, it should be preferred to the hindlimb model for many research purposes...
- Promoting nerve regeneration through long gaps using a small nerve tissue graft
Department of Orthopedic Surgery, Tokai University School of Medicine, Boseidai Isehara, Kanagawa, Japan
Surg Neurol 59:148-54; discussion 154-5. 2003
If nerve tissue is capable of inducing regeneration, as suggested by the neurotropism theory, then even small pieces of nerve tissue should have the potential to induce nerve regeneration...
- A hyaluronan-based nerve guide: in vitro cytotoxicity, subcutaneous tissue reactions, and degradation in the rat
Department of Plastic and Reconstructive Surgery, University Hospital and University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
Biomaterials 25:483-9. 2004
..The results show that a hyaluronan-based conduit is not cytotoxic and shows good biocompatibility. Such a conduit may be suitable as a guide in peripheral nerve repair...
- The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury
Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
Biomaterials 25:5839-46. 2004
- [Construction of artificial nerve bridge by three-dimensional culture of Schwann cells with human hair keratins]
Institute of Clinical Anatomy, Southern Medical University, Guangzhou 510515, China
Di Yi Jun Yi Da Xue Xue Bao 25:1128-31, 1144. 2005
..To culture Schwann cells (SCs) and human hair keratins (HHKs) for artificial nerve bridge construction...
- Neuro tissue engineering of glial nerve guides and the impact of different cell types
NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Markwiesenstr 55, D 72770 Reutlingen, Germany
Biomaterials 27:1425-36. 2006
..In summary, for more rapid regrowth, functional boB can be induced by guided microtissue engineering. By considering both the negative and positive effects of cell interactions, a more rational design of nerve implants becomes feasible...
- Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to that of nerve autografts
matREGEN Corporation, 200 College Street, Suite 28, Toronto, Ont, Canada M5S 3E5
Biomaterials 27:505-18. 2006
..These coil-reinforced tubes demonstrated equivalence to autografts for nerve regeneration, demonstrating the importance of channel design to regenerative capacity and more specifically the impact of patency to regeneration...
- Viability and electrophysiology of neural cell structures generated by the inkjet printing method
Department of Bioengineering, Clemson University, Clemson, SC 29634, USA
Biomaterials 27:3580-8. 2006
..These results and findings, taken together, show that inkjet printing is rapidly evolving into a digital fabrication method to build functional neural structures that may eventually find applications in neural tissue engineering...
- Cellular identification of water gustatory receptor neurons and their central projection pattern in Drosophila
Department of Biology, Graduate School of Sciences, Kyushu University, Ropponmatsu, Fukuoka 810 8560, Japan
Proc Natl Acad Sci U S A 103:1094-9. 2006
..We show here that the water receptor neurons project to a specific region in the subesophageal ganglion, thus revealing the water taste sensory map in Drosophila...
- [Transplantation of cerebral neurons into spinal cord for the treatment of paraplegia]
Jesús Vaquero Crespo
An R Acad Nac Med (Madr) 120:47-61; discussion 62-3. 2003
..the experimental results obtained after microsurgical cotransplantation of fetal cerebral tissue and peripheral nerve tissue into previously injured spinal cord...
- Peripheral nerve regeneration through allografts compared with autografts in FK506-treated monkeys
Department of Plastic and Reconstructive Surgery, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
J Neurosurg 105:602-9. 2006
..The purpose of this study was to compare the nerve regeneration obtained using ulnar nerve allografts in nonhuman primates temporarily treated with FK506 (tacrolimus) with that obtained using nerve autografts...
- Polypyrrole doped with 2 peptide sequences from laminin
William R Stauffer
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
Biomaterials 27:2405-13. 2006
..Finally, the astrocyte studies demonstrate that PPy surfaces have significantly less astrocyte adhesion in culture than the common electrode material, gold...
- Three-dimensional growth and function of neural tissue in degradable polyethylene glycol hydrogels
Melissa J Mahoney
Department of Chemical and Biological Engineering and the Howard Hughes Medical Institute, University of Colorado, Boulder, 80309, USA
Biomaterials 27:2265-74. 2006
..These studies were carried out in the absence of serum and extracellular matrix molecules that can be immunogenic and identify degradable PEG hydrogels as suitable synthetic cell carriers for neural transplantation...
- Manufacture of porous polymer nerve conduits through a lyophilizing and wire-heating process
Yi Cheng Huang
Institute of Biomedical Engineering, College of Engineering, College of Medicine, National Taiwan University, Taipei, Republic of China
J Biomed Mater Res B Appl Biomater 74:659-64. 2005
We have developed a method for nerve tissue regeneration using longitudinally oriented channels within biodegradable polymers created by a combined lyophilizing and wire-heating process...
- Kalirin, a GDP/GTP exchange factor of the Dbl family, is localized to nerve, muscle, and endocrine tissue during embryonic rat development
D E Hansel
Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Histochem Cytochem 49:833-44. 2001
..This is the first identification of kalirin expression in embryonic tissue and the first demonstration of non-neuronal expression of kalirin. (J Histochem Cytochem 49:833-844, 2001)..
- Tic disorders: neural circuits, neurochemistry, and neuroimmunology
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
J Child Neurol 21:678-89. 2006
..We review the neural circuits and neurochemistry of Tourette syndrome and evaluate the evidence for and against a role for autoimmunity in the expression of tics...
- Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect
E M Rath
Brain and Development Research Center, University of North Carolina, Chapel Hill 27599 7250, USA
J Neurosci 15:7226-37. 1995
..This Schwann cell differentiation defect likely accounts for both the peripheral neuropathy and impaired nerve regeneration observed in Enr mice...
- Functional innervation in tissue engineered models for in vitro study and testing purposes
Erik J Suuronen
University of Ottawa Eye Institute, Ottawa Health Research Institute Vision Centre, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8L6, Canada
Toxicol Sci 82:525-33. 2004
..These results are important to consider for the development of any optimized TE models for in vitro study and testing purposes...
- Aragonite crystalline biomatrices support astrocytic tissue formation in vitro and in vivo
Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Tissue Eng 12:1763-73. 2006
..Hence, we suggest that the biomatrix is a biocompatible supportive scaffold for astrocytes and may be exploited in applications for neuronal tissue restoration in injured or diseased central nervous system...
- Impact of cell type and density on nerve growth factor distribution and bioactivity in 3-dimensional collagen gel cultures
Melissa J Mahoney
Chemical and Biological Engineering, University of Colorado, Boulder, Colorado, USA
Tissue Eng 12:1915-27. 2006
..This approach may be useful in customizing NGF distribution throughout degenerating or damaged central nervous system tissue while minimizing toxicity to surrounding healthy tissue...
- Hyperbaric oxygen treatment has different effects on nerve regeneration in acellular nerve and muscle grafts
Department of Orthopaedic Surgery, University of Tsukuba, Japan
J Peripher Nerv Syst 6:73-8. 2001
- MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells
Division of Biology 216 76, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
Curr Biol 7:440-50. 1997
..The relationship between expression of MASH1 and the neurogenic competence of neural crest cells has not been investigated, however...
- Nerve-target interactions in the gustatory system following unilateral chorda tympani nerve section
David L Hill
Department of Psychology, University of Virginia, Charlottesville, Virginia, VA 22904, USA
Chem Senses 30:i64-5. 2005
- Neuronal function and alpha3 isoform of the Na/K-ATPase
Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Front Biosci 10:2373-96. 2005
- Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
J Neurosci 28:7891-9. 2008
..Nontoxic ceramide modulators might usefully promote sprouting and circuitry repair in neurodegenerative disorders in which ceramide species are perturbed, adding to the benefits of reducing ceramide-induced neuronal apoptosis...
- White matter inhibitors in CNS axon regeneration failure
Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0691, USA
Exp Neurol 209:302-12. 2008
- The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
Laboratoire d Analyse Ultrastructurale, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne, Switzerland
Proc Natl Acad Sci U S A 102:19192-7. 2005
..2-nm periodic transcleft complexes. Previously undescribed structures of presynaptic and postsynaptic elements are also described...
- Comparison of asymptotics of heart and nerve excitability
Department of Mathematical Sciences, Liverpool University, Mathematics and Oceanography Building, Peach Street, Liverpool L69 7ZL, United Kingdom
Phys Rev E Stat Nonlin Soft Matter Phys 68:011902. 2003
- Nerve-sparing therapy with oncolytic herpes virus for cancers with neural invasion
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Clin Cancer Res 13:6479-85. 2007
..Herpes simplex viruses (HSV) have utility for gene transfer into nerves and as oncolytic agents. We studied the use of an attenuated HSV, NV1023, as treatment for cancers with neural invasion...
- Bridging defects: autologous nerve grafts
Millesi Center for the Surgery of Brachial Plexus and Peripheral Nerve Lesions, Vienna Private Clinic, Vienna, Austria
Acta Neurochir Suppl 100:37-8. 2007
..However, in vast defects like brachial plexus lesions, the number of available autografts is insufficient. We do need alternative techniques like tubulisation, however, not to replace autologous nerve grafts but to supplement them...
- Photoengineering of neural tissue repair processes in peripheral nerves and the spinal cord: research development with clinical applications
Division of Peripheral Nerve Reconstruction, Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
Photomed Laser Surg 24:151-7. 2006
..requires much research to elucidate the biological mechanisms through which phototherapy exerts its effects on nerve tissue, and to provide clinicians with the basis for planning clinical trials on the use of phototherapy for enhancing ..
- Spinal cord injuries: making the re-connection
Norman R Saunders
Department of Pharmacology, University of Melbourne, Australia
Biologist (London) 49:107-12. 2002
- Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit
Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistr 380, D 30659 Hannover, Germany
J Cell Mol Med 10:770-7. 2006
..In our study, we describe for the first time the use of spider silk fibres as a new material in nerve tissue engineering. Schwann cells (SC) were cultivated on spider silk fibres...
- Surgical therapy of peripheral nerve lesions: current status and new perspectives
Department of Plastic, Reconstructive, and Hand Surgery, Burn Center, Klinikum Bogenhausen Städtisches Klinikum München GmbH, Munich, Germany
Zentralbl Neurochir 68:101-10. 2007
..This article also reviews the developments in the use of alternative nerve guides and demonstrates new perspectives in the field of peripheral nerve reconstruction...
- Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins
J V Coumans
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
J Neurosci 21:9334-44. 2001
- Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry
UMR INRA ENVT, Physiopathologie Infectieuse et Parasitaire des Ruminants, Ecole Nationale Veterinaire, Toulouse, France
J Histochem Cytochem 50:1357-70. 2002
..This technique constitutes a useful tool for IHC investigation of scrapie pathogenesis and may be applicable to the study of other ovine infectious diseases...
- Neuro-glial neurotrophic interaction in the S-100 beta retarded mutant mouse (Polydactyly Nagoya). III. Transplantation study
Department of Histology and Neurobiology, Dokkyo University School of Medicine, Tochigi, Japan
Brain Res 738:15-23. 1996
..The present results suggest that the expression of S-100 beta in the astrocytes of early stage of transplantation is a critical for fiber ingrowth of serotonergic neurons and expressions of 5-HT1A receptor...
- gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots
Richard M LoPachin
Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467 2490, USA
Toxicol Appl Pharmacol 193:29-46. 2003
..Appl. Pharmacol. 135 (1995) 58; and Toxicol. Appl. Pharmacol. 165 (2000) 127) indicate that axon atrophy, and not axonal swelling, is a primary neuropathic phenomenon...
- Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes?
INSERM U 666, Faculty of Medicine, Strasbourg, France
Glia 55:1238-50. 2007
..Finally, the sequence of metabolic changes occurring during a transient increase of electrical activity in specific regions of the brain remains to be clarified...
- Separate development of nitric oxide synthase- and vasoactive intestinal polypeptide-immunoreactive nerves arising from the vertebral artery in the rat
Biological Laboratory, Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kyushu Sangyo University, Higashi ku, Fukuoka 813 8530, Japan
J Vet Med Sci 68:125-30. 2006
..Thus, NOS-IR nerves coming from the VA develop through its own characteristic sequence that lags markedly behind the time of appearance for VIP-IR nerves from the same vascular route and for NOS-IR and VIP-IR nerves via the AC...
- Neuronal cell injury precedes brain atrophy in multiple sclerosis
John A Kamholz
Neurology 64:176; author reply 176. 2005
- Effects of hyperglycemia on rat cavernous nerve axons: a functional and ultrastructural study
Elena G Zotova
Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
Exp Neurol 213:439-47. 2008
..The physiologic techniques outlined in these studies are feasible in most electrophysiologic laboratories and could substantially enhance our sensitivity to the onset and progression of small fiber diabetic neuropathy...
- Changes of cytoskeletal proteins in nerve tissues and serum of rats treated with 2,5-hexanedione
Qing shan Wang
Institute of Toxicology, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China
Toxicology 244:166-78. 2008
..NF-H was the most sensitive index, which may serve as a good indicator for neurotoxicity of n-hexane or HD...
- The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegans
Department of Molecular and Medical Genetics, University of Toronto, Toronto M5S 1A8, Canada
Genes Dev 14:2486-500. 2000
..Genetic interactions confirm that UNC-129 does not require the only known type II TGF-beta receptor in C. elegans (DAF-4) for its guidance functions. Also, unc-130 is partially required for male tail morphogenesis and for embryogenesis...
- Experimental nerve imaging at 1.5-T
Department of Neuroradiology, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
Methods 43:21-8. 2007
..g., blood vessels. Furthermore, we give an overview on different types of contrast agents used for peripheral nerve MR imaging and MR findings in selected experimental models of rat peripheral nerve injury...
- The "bioartificial living nerve graft"
Clinic for Plastic, Hand and Reconstructive Surgery, Burn Centre Medical University Hannover, Hannover, Germany
Acta Neurochir Suppl 100:65-7. 2007
..To imitate the three-dimensional structure of peripheral nerves, we designed a Schwann cell-seeded intrinsic framework within a semipermeable biodegradable collagen nerve tube (Integra)...
- Expression of Bcl-2, Bax and Caspase-3 in nerve tissues of rats chronically exposed to 2,5-hexanedione
Institute of Toxicology, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, P R China
Neurochem Res 32:1566-72. 2007
- Surface modification of neural probes with conducting polymer poly(hydroxymethylated-3,4- ethylenedioxythiophene) and its biocompatibility
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China
Appl Biochem Biotechnol 128:117-30. 2006
..An in vitro experiment demonstrated that the neuroblastoma cells grew preferentially on the PEDOT-MeOH/CDPGYIGSR-coated electrode sites and spread beyond the electrode area...
- Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
Regul Pept 126:109-13. 2005
..These results suggest that this in vitro neuronal culture system will be a useful model for future studies on the functional role of the PACAPergic system during different stages of neuronal development...
- Computation of the electrical potential inside the nerve induced by an electrical stimulus
Odyssée Laboratory ENPC ENS INRIA, 2004 route des Lucioles, BP93, 06902, Sophia Antipolis, France
Conf Proc IEEE Eng Med Biol Soc 2007:1711-4. 2007
..Our results show that the distribution of the electrical potential inside a nerve or a fascicle depends on the geometry of the electrode and the shape of the applied current...
- High b-value q-space diffusion MRS of nerves: structural information and comparison with histological evidence
School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
NMR Biomed 21:165-74. 2008
..These findings are discussed in the context of component assignment, origin of restriction, and relationships between the structural information extracted from q-space diffusion MRS and histological examination...
- Role of cerebrospinal fluid pressure in the pathogenesis of glaucoma
Jost B Jonas
Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
Acta Ophthalmol 89:505-14. 2011
..cribrosa and peripapillary sclera, retrobulbar orbital cerebrospinal fluid pressure and the retrobulbar optic nerve tissue pressure may be of importance for the pathogenesis of the highly myopic type of chronic open-angle glaucoma; (..
- High levels of GM1-ganglioside beta-galactosidase in the salivary glands and GM1-like-ganglioside storage in parotids of deficient mice
School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
J Craniofac Genet Dev Biol 19:41-7. 1999
..GM1-like-ganglioside, typically found at high levels only in the nerve tissue, where its exact function is still not clear, was demonstrated in storage vacuoles of the parotid glands of the ..
- Protein markers in cerebrospinal fluid in experimental nerve root injury. A study of slow-onset chronic compression effects or the biochemical effects of nucleus pulposus on sacral nerve roots
J S Skouen
University of Bergen, Section of Diagnostic Radiology, Haukeland University
Spine (Phila Pa 1976) 24:2195-200. 1999
STUDY DESIGN: Measurement of changes in cerebrospinal fluid concentrations of nerve tissue markers, total proteins, and immunoglobulin after compression of nerve root or application of nucleus pulposus in a pig model...
- Quantitative determination of endogenous sorbitol and fructose in human nerve tissues by atmospheric-pressure chemical ionization liquid chromatography/tandem mass spectrometry
H R Liang
Tandem Labs, A Division of NWT Inc, Salt Lake City, UT, USA
Rapid Commun Mass Spectrom 19:2284-94. 2005
..Human nerve tissue samples were extracted by protein precipitation followed by mixed-mode solid-phase extraction...
- Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus
Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
J Neurosurg 114:414-25. 2011
..The cause of this late-onset deterioration of hearing is not completely understood. The aim of this study was to investigate the possibility that reactive gliosis is a contributory factor...
- Markers of nerve tissue injury in the cerebrospinal fluid in patients with lumbar disc herniation and sciatica
Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Sweden
Spine (Phila Pa 1976) 24:742-6. 1999
..The light subunit of neurofilament protein, S-100 protein, neuron-specific enolase, and glial fibrillary acidic protein were determined in the cerebrospinal fluid in patients with lumbar disc herniation and in control patients...
- Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G
Center for Neuroscience, Louisiana State University Health Science Center, New Orleans, Louisiana, USA
J Neurosurg 97:1424-31. 2002
..The authors wanted to determine if ankyrin G could be detected in neuroma, and if present, whether there would be differences in distribution between nonpainful neuromas, painful neuromas, and normal nerve...
- Evaluation and discrimination of simvastatin-induced structural alterations in proteins of different rat tissues by FTIR spectroscopy and neural network analysis
Department of Biochemistry, Middle East Technical University, Ankara, 06531, Turkey
Analyst 135:3233-41. 2010
..According to the heterogeneity values in the cluster analysis of these tissues, the sciatic nerve tissue was found to be the most affected tissue from simvastatin treatment among the studied soft tissues...
- Cavernous hemangioma of the abducens nerve: clinical implication of duplicated variants: case report
Kyung Sub Moon
Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Gwangju, South Korea
Neurosurgery 69:E756-60; discussion E760. 2011
..Based on the surgical experience with this case, the authors discuss the clinical importance and resectability potential of a duplicated abducens nerve...
- Relative neural toxicity of local anesthetics
M W Kalichman
Department of Anesthesiology, University of California, San Diego 92093 9151
J Neuropathol Exp Neurol 52:234-40. 1993
..As measures of neural toxicity, nerve fiber injury and edema were assayed by light microscopic examination of nerve tissue sampled 2 days after perineural (next to the sciatic nerve) injection of various concentrations of the local ..
- Human neuroma contains increased levels of semaphorin 3A, which surrounds nerve fibers and reduces neurite extension in vitro
Martijn R Tannemaat
Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands
J Neurosci 27:14260-4. 2007
..to increased neurite outgrowth of F11 cells cultured on neuroma tissue, but not of F11 cells cultured on normal nerve tissue. These findings demonstrate the putative inhibitory role of sema3A in human neuroma tissue...
- Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells
Ruaidhri P Kirwan
Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
Mol Vis 15:76-88. 2009
..We report the first study of global and ECM-focused gene transcription differentials between GFAP-negative lamina cribrosa (LC) cells from normal and POAG human donors...
- Effect of low-intensity pulsed ultrasound on the expression of neurotrophin-3 and brain-derived neurotrophic factor in cultured Schwann cells
Department of Orthopaedics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Microsurgery 29:479-85. 2009
It is generally known that low-intensity pulsed ultrasound (LIPUS) accelerates peripheral nerve tissue regeneration. However, the precise cellular mechanism involved is still unclear...
- Intraorbital optic nerve stimulation with penetrating electrodes: in vivo electrophysiology study in rabbits
Institute for Laser Medicine and Bio Photonics, Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China
Graefes Arch Clin Exp Ophthalmol 247:349-61. 2009
..To investigate the response properties of the electrically evoked potentials (EEPs) elicited by intraorbital optic nerve stimulation with penetrating electrodes using different stimulus parameters...
- Molecular cloning and pharmacological characterization of a Bombyx mori tyramine receptor selectively coupled to intracellular calcium mobilization
Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan
Insect Biochem Mol Biol 39:842-9. 2009
..cDNA encoding the TA receptor (TAR) BmTAR2 was cloned from the nerve tissue of the silkworm Bombyx mori...
- Chondroitinase ABC (pharmaceutical grade) for chemonucleolysis. Functional and structural evaluation after local application on intraspinal nerve structures and blood vessels
Department of Orthopaedics, Sahlgren University Hospital, Gothenburg, Sweden, USA
Spine (Phila Pa 1976) 21:1952-6. 1996
The effects on nerve tissue and blood vessels of locally applied chondroitinase ABC were studied in two experimental models using chymopapain and the vehicle of chondroitinase ABC for controls.
- [Effects of neurotrophic factor 3 gene modified SC on sciatic nerve regeneration in rats]
Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Weihui Henan, 453100, PR China
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1104-9. 2009
..To investgate the effects of neurotrophic factor 3 (NT-3) genes modified SC on facilitating nerve regeneration and protecting neuronal survival after the sciatic nerve transection in rats...
- Myelin formation by Schwann cells in the absence of beta4 integrin
Department of Neurology, Section of Developmental Neurobiology, University of Wurzburg, Wurzburg, Germany
Glia 27:269-74. 1999
..e., in peripheral nerve tissue from beta4 integrin-deficient mice...
- Nerve fibers in uterosacral ligaments of women with deep infiltrating endometriosis
Adolpho Roberto Kelm Junior
Ob Gyn Department, Santa Casa Medical School, Sao Paulo, Brazil
J Reprod Immunol 79:93-9. 2008
Endometriosis is a disease of high prevalence and enigmatic origin. One aspect not yet clarified is the relationship between endometriosis and nerve tissue.
- Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain
Department of Neurology, School of Health Sciences, Section of Medicine, University of Crete, Heraklion, Crete, Greece
J Neurosci Res 66:899-908. 2001
..human, GDH exists in heat-resistant and heat-labile isoforms, encoded by the GLUD1 (housekeeping) and GLUD2 (nerve tissue-specific) genes, respectively. These forms differ in their catalytic and allosteric properties...
- Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung
Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, 236 0004, Yokohama, Japan
Mech Dev 97:35-45. 2000
..CRMP (CRMP-2), an intracellular protein mediating Sema3A signaling, was localized in alveolar epithelial cells, nerve tissue and airway neuroendocrine cells...
- Rudolf Virchow and presentation of his scientific achievement in Polish medical magazines in the 19th century and the beginning of 20th century
Department of Pathomorphology, Medical Faculty in Zabrze, Silesian Academy of Medicine, Katowice
Pol J Pathol 53:163-8. 2002
..Also a translation of the XI chapter of "Cellular pathology..." devoted to nerve tissue appeared in the same magazine...
- Assessing the effects of three dental impression materials on the isolated sciatic nerve of rat and frog
Laboratory of Animal Physiology, School of Biology, Aristotle University, Thessaloniki 54124, Hellas, Greece
Toxicol In Vitro 21:103-8. 2007
The effects on nerve tissue of three dental impression pastes were compared in this study. Two of the impression pastes, Examix and Express 3M, contained vinyl polysiloxane while the other, Xanthopren, did not...
- Cholestanol metabolism in patients with cerebrotendinous xanthomatosis: absorption, turnover, and tissue deposition
Ashim K Bhattacharyya
Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
J Lipid Res 48:185-92. 2007
..0 in plasma and liver to 30.0 in the cerebellar xanthoma; cholestanol was especially high in nerve tissue. Our data indicate that CTX patients absorb cholestanol from the diet...
- Molecular cloning and heterologous expression of an alpha-adrenergic-like octopamine receptor from the silkworm Bombyx mori
Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan
Insect Mol Biol 15:763-72. 2006
A cDNA encoding an octopamine (OA) receptor (BmOAR1) was isolated from the nerve tissue of silkworm (Bombyx mori) larvae...
- Ablation of T cell immunity differentially influences tumor risk in inbred BD rat strains
Judith A M Marx
Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, Bonn, Germany
Cancer Immunol Immunother 58:1287-95. 2009
..Initially considerable amounts of Neu/ErbB-2-mutant cells arise in nerve tissue of both rat strains subsequently disappearing in resistant BDIV rats, but persisting and giving rise to MPNST ..
- Anatomical distribution of avian bornavirus in parrots, its occurrence in clinically healthy birds and ABV-antibody detection
Institute for Poultry Diseases, Freie Universitaet Berlin, Germany
Avian Pathol 38:491-6. 2009
..Viraemia was observed in a PDD-affected bird whereas a restriction of ABV to nerve tissue was found in the non-PDD-affected bird...
- Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR
Najam A Sharif
Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
Mol Vis 12:1040-7. 2006
..To determine the relative density and tissue localization of mRNAs for serotonin (5-hydroxytryptamine; 5HT) receptor subtypes in human ocular tissues and correlate with their possible functions in the eye...
- Co-infection with two different Campylobacter jejuni strains in a patient with the Guillain-Barré syndrome
Peggy C R Godschalk
Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Microbes Infect 8:248-53. 2006
..molecular mimicry between bacterial sialylated lipo-oligosaccharides (LOS) and gangliosides in peripheral nerve tissue. We investigated whether co-infections with multiple C...
- Histological considerations of the cleavage plane for preservation of facial and cochlear nerve functions in vestibular schwannoma surgery
Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Neurosurg 110:648-55. 2009
..The authors analyzed the tumor capsule and the tumor-nerve interface in vestibular schwannomas (VSs) to define the ideal cleavage plane for maximal tumor removal with preservation of facial and cochlear nerve functions...
- Tissue distribution and deposition of clofazimine in mice following oral administration with or without isoniazid
National JALMA Institute for Leprosy and Other Mycobacterial Diseases ICMR, Agra, India
Arzneimittelforschung 57:472-4. 2007
..1-42.8 microg/g of wet tissue). There was a significant amount of the drug in foot pads and pooled nerve tissue showed detectable amount of the drug. The plasma concentrations in all treated groups were in the range of 0...
- Detection of genomic viral RNA in nerve and muscle of patients with HCV neuropathy
F J Authier
Groupe Nerf Muscle, Departement de Pathologie, Hopital Henri Mondor, Creteil, France
Neurology 60:808-12. 2003
..MC may contain viral RNA, and tissues showing vasculitis may contain intracellular HCV. Local HCV replication remains to be evidenced...
- First single movement of turkey embryos
Diedrich Graf von Keyserlingk
Department of Histology and Embryology, Kaunas University of Medicine, Kaunas, Lithuania
Medicina (Kaunas) 41:592-602. 2005
..The space of time of the contraction since beginning of incubation, topography, morphogenesis and histology of the concerned muscle and its mechanical counterpart are described...
- Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response
Hung Chuan Pan
Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan
Magnes Res 24:54-70. 2011
..First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations...
- Current recommendations for the prophylaxis and treatment of rabies
D W Dreesen
Department of Medical Microbiology, University of Georgia, Athens, USA
Drugs 56:801-9. 1998
..b>Nerve tissue origin vaccines, although used extensively in some parts of the world, are not recommended if cell or tissue ..