nerve tissue

Summary

Top Publications

  1. ncbi Neural tissue engineering: a self-organizing collagen guidance conduit
    James B Phillips
    University College London, Tissue Repair and Engineering Centre, Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
    Tissue Eng 11:1611-7. 2005
  2. pmc Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineering
    Elahe Masaeli
    Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
    PLoS ONE 8:e57157. 2013
  3. ncbi Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    Islamic Azad University, Najafabad Branch, Isfahan, Iran
    J Tissue Eng Regen Med 5:e17-35. 2011
  4. ncbi Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    NUS Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore
    Biomaterials 29:4532-9. 2008
  5. ncbi Electrospun PLGA-silk fibroin-collagen nanofibrous scaffolds for nerve tissue engineering
    Guanglin Wang
    Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
    In Vitro Cell Dev Biol Anim 47:234-40. 2011
  6. ncbi Photofabricated gelatin-based nerve conduits: nerve tissue regeneration potentials
    Eduardo Gámez
    Division of Biomedical Engineering, Graduate School of Dental Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cell Transplant 13:549-64. 2004
  7. ncbi Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering
    Molamma P Prabhakaran
    Nanoscience and Nanotechnology Initiative, Division of Bioengineering, 9 Engineering Drive 1, National University of Singapore, Singapore 117576, Singapore
    Biomaterials 30:4996-5003. 2009
  8. pmc Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves
    Ziv Gil
    Department of Otolaryngology, Head and Neck Surgery, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv, 64239, Israel
    J Natl Cancer Inst 102:107-18. 2010
  9. pmc Mass spectrometric-based proteomic analysis of amyloid neuropathy type in nerve tissue
    Christopher J Klein
    Department of Neurology Peripheral Nerve Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 68:195-9. 2011
  10. ncbi Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP
    P Shashidharan
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, U S A
    J Neurochem 68:1804-11. 1997

Detail Information

Publications259 found, 100 shown here

  1. ncbi Neural tissue engineering: a self-organizing collagen guidance conduit
    James B Phillips
    University College London, Tissue Repair and Engineering Centre, Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Stanmore, Middlesex, UK
    Tissue Eng 11:1611-7. 2005
    ..Neural regeneration through this device was significantly greater than in controls, demonstrating that this system has potential both as a simple robust clinical implant and as a three-dimensional engineered tissue model...
  2. pmc Fabrication, characterization and cellular compatibility of poly(hydroxy alkanoate) composite nanofibrous scaffolds for nerve tissue engineering
    Elahe Masaeli
    Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran
    PLoS ONE 8:e57157. 2013
    ..this study demonstrate that aligned PHB/PHBV electrospun nanofibers could find potential use as scaffolds for nerve tissue engineering applications and that the presence of type I collagen in the nanofibers improves cell ..
  3. ncbi Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    Islamic Azad University, Najafabad Branch, Isfahan, Iran
    J Tissue Eng Regen Med 5:e17-35. 2011
    ..makes the use of electrically conductive polymers very attractive for the construction of scaffolds for nerve tissue engineering...
  4. ncbi Electrospun poly(epsilon-caprolactone)/gelatin nanofibrous scaffolds for nerve tissue engineering
    Laleh Ghasemi-Mobarakeh
    NUS Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore
    Biomaterials 29:4532-9. 2008
    b>Nerve tissue engineering is one of the most promising methods to restore nerve systems in human health care. Scaffold design has pivotal role in nerve tissue engineering...
  5. ncbi Electrospun PLGA-silk fibroin-collagen nanofibrous scaffolds for nerve tissue engineering
    Guanglin Wang
    Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
    In Vitro Cell Dev Biol Anim 47:234-40. 2011
    ..have been performed to examine the PLGA-silk fibroin-collagen (PLGA-SF-COL) biocomposite fiber matrices for nerve tissue engineering...
  6. ncbi Photofabricated gelatin-based nerve conduits: nerve tissue regeneration potentials
    Eduardo Gámez
    Division of Biomedical Engineering, Graduate School of Dental Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cell Transplant 13:549-64. 2004
    ..Prior to study on nerve tissue engineering using Schwann cells or nerve stem cells, the effectiveness of photofabricated scaffolds based on ..
  7. ncbi Mesenchymal stem cell differentiation to neuronal cells on electrospun nanofibrous substrates for nerve tissue engineering
    Molamma P Prabhakaran
    Nanoscience and Nanotechnology Initiative, Division of Bioengineering, 9 Engineering Drive 1, National University of Singapore, Singapore 117576, Singapore
    Biomaterials 30:4996-5003. 2009
    ..Our studies on the differentiation of MSCs to neuronal cells on nanofibrous scaffolds suggest their potential application towards nerve regeneration...
  8. pmc Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves
    Ziv Gil
    Department of Otolaryngology, Head and Neck Surgery, Tel Aviv Sourasky Medical Center, 6 Weizmann St, Tel Aviv, 64239, Israel
    J Natl Cancer Inst 102:107-18. 2010
    ..For these tumors, nerves may provide a conduit for local cancer progression into the central nervous system. Although neural invasion is associated with poor outcome, the mechanism that triggers it is unknown...
  9. pmc Mass spectrometric-based proteomic analysis of amyloid neuropathy type in nerve tissue
    Christopher J Klein
    Department of Neurology Peripheral Nerve Laboratory, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Arch Neurol 68:195-9. 2011
    ..To determine the specific type of amyloid from nerve biopsies using laser microdissection (LMD) and mass spectrometric (MS)-based proteomic analysis...
  10. ncbi Nerve tissue-specific human glutamate dehydrogenase that is thermolabile and highly regulated by ADP
    P Shashidharan
    Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, U S A
    J Neurochem 68:1804-11. 1997
    ..However, in the absence of ADP, the nerve tissue-specific GDH showed only 5% of its maximal activity, compared with approximately 40% showed by the housekeeping ..
  11. pmc Genome-wide microRNA profiling in human fetal nervous tissues by oligonucleotide microarray
    Jian Jun Zhao
    Department of Genetics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Childs Nerv Syst 22:1419-25. 2006
    ..Our objective was to develop an oligonucleotide DNA microarray (OMA) for genome-wide microRNA profiling and use this method to find miRNAs, which control organic development especially for nervous system...
  12. ncbi Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function
    A Plaitakis
    Department of Neurology, University of Crete, School of Health Sciences, Section of Medicine, Heraklion, Crete, Greece
    J Neurochem 75:1862-9. 2000
    ..dehydrogenase (GDH), an enzyme central to the metabolism of glutamate, is known to exist in housekeeping and nerve tissue-specific isoforms encoded by the GLUD1 and GLUD2 genes, respectively...
  13. ncbi Porous chitosan tubular scaffolds with knitted outer wall and controllable inner structure for nerve tissue engineering
    Aijun Wang
    Department of Biological Sciences and Biotechnology, State Key Laboratory of Biomembrane and Membrane Biotechnology, Tsinghua University, Beijing 100084, China
    J Biomed Mater Res A 79:36-46. 2006
    ..tubular scaffolds with desirable mechanical properties and controllable inner structure from chitosan, for nerve tissue engineering...
  14. ncbi Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro
    Masaru Ishibashi
    Division of Bio Information Engineering, Faculty of Engineering, Toyama University, 3190 Gofuku, Toyama 930 8555, Japan
    Peptides 26:471-81. 2005
    ....
  15. ncbi Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps
    B A Harley
    Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Mass, USA
    Cells Tissues Organs 176:153-65. 2004
    ..The data show the presence of a hitherto unreported optimal chamber degradation rate that leads to regenerated nerves of maximum quality...
  16. ncbi Functional, morphological and biomolecular assessment of posttraumatic neuro-muscular recovery in the rat forelimb model
    S Geuna
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Hospitale San Luigi, Torino, Italy
    Acta Neurochir Suppl 100:173-7. 2007
    ..Furthermore, since the forelimb model is less compromising for the animal, it should be preferred to the hindlimb model for many research purposes...
  17. ncbi Promoting nerve regeneration through long gaps using a small nerve tissue graft
    Ikuo Saito
    Department of Orthopedic Surgery, Tokai University School of Medicine, Boseidai Isehara, Kanagawa, Japan
    Surg Neurol 59:148-54; discussion 154-5. 2003
    If nerve tissue is capable of inducing regeneration, as suggested by the neurotropism theory, then even small pieces of nerve tissue should have the potential to induce nerve regeneration...
  18. ncbi A hyaluronan-based nerve guide: in vitro cytotoxicity, subcutaneous tissue reactions, and degradation in the rat
    K Jansen
    Department of Plastic and Reconstructive Surgery, University Hospital and University of Groningen, Hanzeplein 1, Groningen 9713 GZ, The Netherlands
    Biomaterials 25:483-9. 2004
    ..The results show that a hyaluronan-based conduit is not cytotoxic and shows good biocompatibility. Such a conduit may be suitable as a guide in peripheral nerve repair...
  19. ncbi The fabrication and characterization of linearly oriented nerve guidance scaffolds for spinal cord injury
    Shula Stokols
    Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093, USA
    Biomaterials 25:5839-46. 2004
    ....
  20. ncbi [Construction of artificial nerve bridge by three-dimensional culture of Schwann cells with human hair keratins]
    Jun Yang
    Institute of Clinical Anatomy, Southern Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 25:1128-31, 1144. 2005
    ..To culture Schwann cells (SCs) and human hair keratins (HHKs) for artificial nerve bridge construction...
  21. ncbi Neuro tissue engineering of glial nerve guides and the impact of different cell types
    Martin Lietz
    NMI Naturwissenschaftliches und Medizinisches Institut an der Universität Tübingen, Markwiesenstr 55, D 72770 Reutlingen, Germany
    Biomaterials 27:1425-36. 2006
    ..In summary, for more rapid regrowth, functional boB can be induced by guided microtissue engineering. By considering both the negative and positive effects of cell interactions, a more rational design of nerve implants becomes feasible...
  22. ncbi Coil-reinforced hydrogel tubes promote nerve regeneration equivalent to that of nerve autografts
    Yusuke Katayama
    matREGEN Corporation, 200 College Street, Suite 28, Toronto, Ont, Canada M5S 3E5
    Biomaterials 27:505-18. 2006
    ..These coil-reinforced tubes demonstrated equivalence to autografts for nerve regeneration, demonstrating the importance of channel design to regenerative capacity and more specifically the impact of patency to regeneration...
  23. ncbi Viability and electrophysiology of neural cell structures generated by the inkjet printing method
    Tao Xu
    Department of Bioengineering, Clemson University, Clemson, SC 29634, USA
    Biomaterials 27:3580-8. 2006
    ..These results and findings, taken together, show that inkjet printing is rapidly evolving into a digital fabrication method to build functional neural structures that may eventually find applications in neural tissue engineering...
  24. pmc Cellular identification of water gustatory receptor neurons and their central projection pattern in Drosophila
    Tsuyoshi Inoshita
    Department of Biology, Graduate School of Sciences, Kyushu University, Ropponmatsu, Fukuoka 810 8560, Japan
    Proc Natl Acad Sci U S A 103:1094-9. 2006
    ..We show here that the water receptor neurons project to a specific region in the subesophageal ganglion, thus revealing the water taste sensory map in Drosophila...
  25. ncbi [Transplantation of cerebral neurons into spinal cord for the treatment of paraplegia]
    Jesús Vaquero Crespo
    An R Acad Nac Med (Madr) 120:47-61; discussion 62-3. 2003
    ..the experimental results obtained after microsurgical cotransplantation of fetal cerebral tissue and peripheral nerve tissue into previously injured spinal cord...
  26. ncbi Peripheral nerve regeneration through allografts compared with autografts in FK506-treated monkeys
    Cristina Auba
    Department of Plastic and Reconstructive Surgery, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain
    J Neurosurg 105:602-9. 2006
    ..The purpose of this study was to compare the nerve regeneration obtained using ulnar nerve allografts in nonhuman primates temporarily treated with FK506 (tacrolimus) with that obtained using nerve autografts...
  27. ncbi Polypyrrole doped with 2 peptide sequences from laminin
    William R Stauffer
    Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Biomaterials 27:2405-13. 2006
    ..Finally, the astrocyte studies demonstrate that PPy surfaces have significantly less astrocyte adhesion in culture than the common electrode material, gold...
  28. ncbi Three-dimensional growth and function of neural tissue in degradable polyethylene glycol hydrogels
    Melissa J Mahoney
    Department of Chemical and Biological Engineering and the Howard Hughes Medical Institute, University of Colorado, Boulder, 80309, USA
    Biomaterials 27:2265-74. 2006
    ..These studies were carried out in the absence of serum and extracellular matrix molecules that can be immunogenic and identify degradable PEG hydrogels as suitable synthetic cell carriers for neural transplantation...
  29. ncbi Manufacture of porous polymer nerve conduits through a lyophilizing and wire-heating process
    Yi Cheng Huang
    Institute of Biomedical Engineering, College of Engineering, College of Medicine, National Taiwan University, Taipei, Republic of China
    J Biomed Mater Res B Appl Biomater 74:659-64. 2005
    We have developed a method for nerve tissue regeneration using longitudinally oriented channels within biodegradable polymers created by a combined lyophilizing and wire-heating process...
  30. ncbi Kalirin, a GDP/GTP exchange factor of the Dbl family, is localized to nerve, muscle, and endocrine tissue during embryonic rat development
    D E Hansel
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Histochem Cytochem 49:833-44. 2001
    ..This is the first identification of kalirin expression in embryonic tissue and the first demonstration of non-neuronal expression of kalirin. (J Histochem Cytochem 49:833-844, 2001)..
  31. ncbi Tic disorders: neural circuits, neurochemistry, and neuroimmunology
    Kendra Harris
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    J Child Neurol 21:678-89. 2006
    ..We review the neural circuits and neurochemistry of Tourette syndrome and evaluate the evidence for and against a role for autoimmunity in the expression of tics...
  32. ncbi Impaired peripheral nerve regeneration in a mutant strain of mice (Enr) with a Schwann cell defect
    E M Rath
    Brain and Development Research Center, University of North Carolina, Chapel Hill 27599 7250, USA
    J Neurosci 15:7226-37. 1995
    ..This Schwann cell differentiation defect likely accounts for both the peripheral neuropathy and impaired nerve regeneration observed in Enr mice...
  33. ncbi Functional innervation in tissue engineered models for in vitro study and testing purposes
    Erik J Suuronen
    University of Ottawa Eye Institute, Ottawa Health Research Institute Vision Centre, and Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, K1H 8L6, Canada
    Toxicol Sci 82:525-33. 2004
    ..These results are important to consider for the development of any optimized TE models for in vitro study and testing purposes...
  34. ncbi Aragonite crystalline biomatrices support astrocytic tissue formation in vitro and in vivo
    B Shany
    Department of Life Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
    Tissue Eng 12:1763-73. 2006
    ..Hence, we suggest that the biomatrix is a biocompatible supportive scaffold for astrocytes and may be exploited in applications for neuronal tissue restoration in injured or diseased central nervous system...
  35. ncbi Impact of cell type and density on nerve growth factor distribution and bioactivity in 3-dimensional collagen gel cultures
    Melissa J Mahoney
    Chemical and Biological Engineering, University of Colorado, Boulder, Colorado, USA
    Tissue Eng 12:1915-27. 2006
    ..This approach may be useful in customizing NGF distribution throughout degenerating or damaged central nervous system tissue while minimizing toxicity to surrounding healthy tissue...
  36. ncbi Hyperbaric oxygen treatment has different effects on nerve regeneration in acellular nerve and muscle grafts
    Y Nishiura
    Department of Orthopaedic Surgery, University of Tsukuba, Japan
    J Peripher Nerv Syst 6:73-8. 2001
    ....
  37. ncbi MASH1 maintains competence for BMP2-induced neuronal differentiation in post-migratory neural crest cells
    L Lo
    Division of Biology 216 76, Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA
    Curr Biol 7:440-50. 1997
    ..The relationship between expression of MASH1 and the neurogenic competence of neural crest cells has not been investigated, however...
  38. ncbi Nerve-target interactions in the gustatory system following unilateral chorda tympani nerve section
    David L Hill
    Department of Psychology, University of Virginia, Charlottesville, Virginia, VA 22904, USA
    Chem Senses 30:i64-5. 2005
  39. ncbi Neuronal function and alpha3 isoform of the Na/K-ATPase
    Maxim Dobretsov
    Department of Anesthesiology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Front Biosci 10:2373-96. 2005
    ....
  40. ncbi Ceramide is responsible for the failure of compensatory nerve sprouting in apolipoprotein E knock-out mice
    Dusica Maysinger
    Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
    J Neurosci 28:7891-9. 2008
    ..Nontoxic ceramide modulators might usefully promote sprouting and circuitry repair in neurodegenerative disorders in which ceramide species are perturbed, adding to the benefits of reducing ceramide-induced neuronal apoptosis...
  41. pmc White matter inhibitors in CNS axon regeneration failure
    Fang Xie
    Department of Neurosciences, University of California San Diego, La Jolla, CA 92093 0691, USA
    Exp Neurol 209:302-12. 2008
    ....
  42. pmc The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
    Benoit Zuber
    Laboratoire d Analyse Ultrastructurale, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 102:19192-7. 2005
    ..2-nm periodic transcleft complexes. Previously undescribed structures of presynaptic and postsynaptic elements are also described...
  43. ncbi Comparison of asymptotics of heart and nerve excitability
    Rebecca Suckley
    Department of Mathematical Sciences, Liverpool University, Mathematics and Oceanography Building, Peach Street, Liverpool L69 7ZL, United Kingdom
    Phys Rev E Stat Nonlin Soft Matter Phys 68:011902. 2003
    ....
  44. ncbi Nerve-sparing therapy with oncolytic herpes virus for cancers with neural invasion
    Ziv Gil
    Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Clin Cancer Res 13:6479-85. 2007
    ..Herpes simplex viruses (HSV) have utility for gene transfer into nerves and as oncolytic agents. We studied the use of an attenuated HSV, NV1023, as treatment for cancers with neural invasion...
  45. ncbi Bridging defects: autologous nerve grafts
    H Millesi
    Millesi Center for the Surgery of Brachial Plexus and Peripheral Nerve Lesions, Vienna Private Clinic, Vienna, Austria
    Acta Neurochir Suppl 100:37-8. 2007
    ..However, in vast defects like brachial plexus lesions, the number of available autografts is insufficient. We do need alternative techniques like tubulisation, however, not to replace autologous nerve grafts but to supplement them...
  46. ncbi Photoengineering of neural tissue repair processes in peripheral nerves and the spinal cord: research development with clinical applications
    Shimon Rochkind
    Division of Peripheral Nerve Reconstruction, Department of Neurosurgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Israel
    Photomed Laser Surg 24:151-7. 2006
    ..requires much research to elucidate the biological mechanisms through which phototherapy exerts its effects on nerve tissue, and to provide clinicians with the basis for planning clinical trials on the use of phototherapy for enhancing ..
  47. ncbi Spinal cord injuries: making the re-connection
    Norman R Saunders
    Department of Pharmacology, University of Melbourne, Australia
    Biologist (London) 49:107-12. 2002
    ....
  48. ncbi Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit
    Christina Allmeling
    Department of Plastic, Hand and Reconstructive Surgery, Medical School Hannover, Podbielskistr 380, D 30659 Hannover, Germany
    J Cell Mol Med 10:770-7. 2006
    ..In our study, we describe for the first time the use of spider silk fibres as a new material in nerve tissue engineering. Schwann cells (SC) were cultivated on spider silk fibres...
  49. ncbi Surgical therapy of peripheral nerve lesions: current status and new perspectives
    U Dornseifer
    Department of Plastic, Reconstructive, and Hand Surgery, Burn Center, Klinikum Bogenhausen Städtisches Klinikum München GmbH, Munich, Germany
    Zentralbl Neurochir 68:101-10. 2007
    ..This article also reviews the developments in the use of alternative nerve guides and demonstrates new perspectives in the field of peripheral nerve reconstruction...
  50. ncbi Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins
    J V Coumans
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA
    J Neurosci 21:9334-44. 2001
    ....
  51. ncbi Phenotyping of protein-prion (PrPsc)-accumulating cells in lymphoid and neural tissues of naturally scrapie-affected sheep by double-labeling immunohistochemistry
    Olivier Andreoletti
    UMR INRA ENVT, Physiopathologie Infectieuse et Parasitaire des Ruminants, Ecole Nationale Veterinaire, Toulouse, France
    J Histochem Cytochem 50:1357-70. 2002
    ..This technique constitutes a useful tool for IHC investigation of scrapie pathogenesis and may be applicable to the study of other ovine infectious diseases...
  52. ncbi Neuro-glial neurotrophic interaction in the S-100 beta retarded mutant mouse (Polydactyly Nagoya). III. Transplantation study
    S Ueda
    Department of Histology and Neurobiology, Dokkyo University School of Medicine, Tochigi, Japan
    Brain Res 738:15-23. 1996
    ..The present results suggest that the expression of S-100 beta in the astrocytes of early stage of transplantation is a critical for fiber ingrowth of serotonergic neurons and expressions of 5-HT1A receptor...
  53. ncbi gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots
    Richard M LoPachin
    Department of Anesthesiology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10467 2490, USA
    Toxicol Appl Pharmacol 193:29-46. 2003
    ..Appl. Pharmacol. 135 (1995) 58; and Toxicol. Appl. Pharmacol. 165 (2000) 127) indicate that axon atrophy, and not axonal swelling, is a primary neuropathic phenomenon...
  54. ncbi Cellular pathways of energy metabolism in the brain: is glucose used by neurons or astrocytes?
    Astrid Nehlig
    INSERM U 666, Faculty of Medicine, Strasbourg, France
    Glia 55:1238-50. 2007
    ..Finally, the sequence of metabolic changes occurring during a transient increase of electrical activity in specific regions of the brain remains to be clarified...
  55. ncbi Separate development of nitric oxide synthase- and vasoactive intestinal polypeptide-immunoreactive nerves arising from the vertebral artery in the rat
    Koichi Ando
    Biological Laboratory, Department of Applied Chemistry and Biochemistry, Faculty of Engineering, Kyushu Sangyo University, Higashi ku, Fukuoka 813 8530, Japan
    J Vet Med Sci 68:125-30. 2006
    ..Thus, NOS-IR nerves coming from the VA develop through its own characteristic sequence that lags markedly behind the time of appearance for VIP-IR nerves from the same vascular route and for NOS-IR and VIP-IR nerves via the AC...
  56. ncbi Neuronal cell injury precedes brain atrophy in multiple sclerosis
    John A Kamholz
    Neurology 64:176; author reply 176. 2005
  57. pmc Effects of hyperglycemia on rat cavernous nerve axons: a functional and ultrastructural study
    Elena G Zotova
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA
    Exp Neurol 213:439-47. 2008
    ..The physiologic techniques outlined in these studies are feasible in most electrophysiologic laboratories and could substantially enhance our sensitivity to the onset and progression of small fiber diabetic neuropathy...
  58. ncbi Changes of cytoskeletal proteins in nerve tissues and serum of rats treated with 2,5-hexanedione
    Qing shan Wang
    Institute of Toxicology, Shandong University, 44 West Wenhua Road, Jinan 250012, PR China
    Toxicology 244:166-78. 2008
    ..NF-H was the most sensitive index, which may serve as a good indicator for neurotoxicity of n-hexane or HD...
  59. pmc The forkhead transcription factor UNC-130 is required for the graded spatial expression of the UNC-129 TGF-beta guidance factor in C. elegans
    B Nash
    Department of Molecular and Medical Genetics, University of Toronto, Toronto M5S 1A8, Canada
    Genes Dev 14:2486-500. 2000
    ..Genetic interactions confirm that UNC-129 does not require the only known type II TGF-beta receptor in C. elegans (DAF-4) for its guidance functions. Also, unc-130 is partially required for male tail morphogenesis and for embryogenesis...
  60. ncbi Experimental nerve imaging at 1.5-T
    Ingo Nolte
    Department of Neuroradiology, Medical Faculty Mannheim of the University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    Methods 43:21-8. 2007
    ..g., blood vessels. Furthermore, we give an overview on different types of contrast agents used for peripheral nerve MR imaging and MR findings in selected experimental models of rat peripheral nerve injury...
  61. ncbi The "bioartificial living nerve graft"
    A Berger
    Clinic for Plastic, Hand and Reconstructive Surgery, Burn Centre Medical University Hannover, Hannover, Germany
    Acta Neurochir Suppl 100:65-7. 2007
    ..To imitate the three-dimensional structure of peripheral nerves, we designed a Schwann cell-seeded intrinsic framework within a semipermeable biodegradable collagen nerve tube (Integra)...
  62. ncbi Expression of Bcl-2, Bax and Caspase-3 in nerve tissues of rats chronically exposed to 2,5-hexanedione
    Ning Cui
    Institute of Toxicology, Shandong University, 44 West Wenhua Road, Jinan, Shandong 250012, P R China
    Neurochem Res 32:1566-72. 2007
    ....
  63. ncbi Surface modification of neural probes with conducting polymer poly(hydroxymethylated-3,4- ethylenedioxythiophene) and its biocompatibility
    Yinghong Xiao
    School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China
    Appl Biochem Biotechnol 128:117-30. 2006
    ..An in vitro experiment demonstrated that the neuroblastoma cells grew preferentially on the PEDOT-MeOH/CDPGYIGSR-coated electrode sites and spread beyond the electrode area...
  64. ncbi Differential expression of mRNAs for PACAP and its receptors during neural differentiation of embryonic stem cells
    Megumi Hirose
    Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Regul Pept 126:109-13. 2005
    ..These results suggest that this in vitro neuronal culture system will be a useful model for future studies on the functional role of the PACAPergic system during different stages of neuronal development...
  65. ncbi Computation of the electrical potential inside the nerve induced by an electrical stimulus
    Sabir Jacquir
    Odyssée Laboratory ENPC ENS INRIA, 2004 route des Lucioles, BP93, 06902, Sophia Antipolis, France
    Conf Proc IEEE Eng Med Biol Soc 2007:1711-4. 2007
    ..Our results show that the distribution of the electrical potential inside a nerve or a fascicle depends on the geometry of the electrode and the shape of the applied current...
  66. ncbi High b-value q-space diffusion MRS of nerves: structural information and comparison with histological evidence
    Amnon Bar-Shir
    School of Chemistry, The Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    NMR Biomed 21:165-74. 2008
    ..These findings are discussed in the context of component assignment, origin of restriction, and relationships between the structural information extracted from q-space diffusion MRS and histological examination...
  67. ncbi Role of cerebrospinal fluid pressure in the pathogenesis of glaucoma
    Jost B Jonas
    Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany
    Acta Ophthalmol 89:505-14. 2011
    ..cribrosa and peripapillary sclera, retrobulbar orbital cerebrospinal fluid pressure and the retrobulbar optic nerve tissue pressure may be of importance for the pathogenesis of the highly myopic type of chronic open-angle glaucoma; (..
  68. ncbi High levels of GM1-ganglioside beta-galactosidase in the salivary glands and GM1-like-ganglioside storage in parotids of deficient mice
    N Nowroozi
    School of Dentistry, University of Southern California, Los Angeles 90089 0641, USA
    J Craniofac Genet Dev Biol 19:41-7. 1999
    ..GM1-like-ganglioside, typically found at high levels only in the nerve tissue, where its exact function is still not clear, was demonstrated in storage vacuoles of the parotid glands of the ..
  69. ncbi Protein markers in cerebrospinal fluid in experimental nerve root injury. A study of slow-onset chronic compression effects or the biochemical effects of nucleus pulposus on sacral nerve roots
    J S Skouen
    University of Bergen, Section of Diagnostic Radiology, Haukeland University
    Spine (Phila Pa 1976) 24:2195-200. 1999
    STUDY DESIGN: Measurement of changes in cerebrospinal fluid concentrations of nerve tissue markers, total proteins, and immunoglobulin after compression of nerve root or application of nucleus pulposus in a pig model...
  70. ncbi Quantitative determination of endogenous sorbitol and fructose in human nerve tissues by atmospheric-pressure chemical ionization liquid chromatography/tandem mass spectrometry
    H R Liang
    Tandem Labs, A Division of NWT Inc, Salt Lake City, UT, USA
    Rapid Commun Mass Spectrom 19:2284-94. 2005
    ..Human nerve tissue samples were extracted by protein precipitation followed by mixed-mode solid-phase extraction...
  71. ncbi Mechanical stress-induced reactive gliosis in the auditory nerve and cochlear nucleus
    Tetsuji Sekiya
    Department of Otolaryngology, Head and Neck Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Neurosurg 114:414-25. 2011
    ..The cause of this late-onset deterioration of hearing is not completely understood. The aim of this study was to investigate the possibility that reactive gliosis is a contributory factor...
  72. ncbi Markers of nerve tissue injury in the cerebrospinal fluid in patients with lumbar disc herniation and sciatica
    H Brisby
    Department of Orthopaedics, Sahlgrenska University Hospital, Goteborg University, Sweden
    Spine (Phila Pa 1976) 24:742-6. 1999
    ..The light subunit of neurofilament protein, S-100 protein, neuron-specific enolase, and glial fibrillary acidic protein were determined in the cerebrospinal fluid in patients with lumbar disc herniation and in control patients...
  73. ncbi Painful neuromas: a potential role for a structural transmembrane protein, ankyrin G
    Thomas Kretschmer
    Center for Neuroscience, Louisiana State University Health Science Center, New Orleans, Louisiana, USA
    J Neurosurg 97:1424-31. 2002
    ..The authors wanted to determine if ankyrin G could be detected in neuroma, and if present, whether there would be differences in distribution between nonpainful neuromas, painful neuromas, and normal nerve...
  74. ncbi Evaluation and discrimination of simvastatin-induced structural alterations in proteins of different rat tissues by FTIR spectroscopy and neural network analysis
    Sebnem Garip
    Department of Biochemistry, Middle East Technical University, Ankara, 06531, Turkey
    Analyst 135:3233-41. 2010
    ..According to the heterogeneity values in the cluster analysis of these tissues, the sciatic nerve tissue was found to be the most affected tissue from simvastatin treatment among the studied soft tissues...
  75. ncbi Cavernous hemangioma of the abducens nerve: clinical implication of duplicated variants: case report
    Kyung Sub Moon
    Department of Neurosurgery, Chonnam National University Research Institute of Medical Sciences, Chonnam National University Hwasun Hospital and Medical School, Gwangju, South Korea
    Neurosurgery 69:E756-60; discussion E760. 2011
    ..Based on the surgical experience with this case, the authors discuss the clinical importance and resectability potential of a duplicated abducens nerve...
  76. ncbi Relative neural toxicity of local anesthetics
    M W Kalichman
    Department of Anesthesiology, University of California, San Diego 92093 9151
    J Neuropathol Exp Neurol 52:234-40. 1993
    ..As measures of neural toxicity, nerve fiber injury and edema were assayed by light microscopic examination of nerve tissue sampled 2 days after perineural (next to the sciatic nerve) injection of various concentrations of the local ..
  77. ncbi Human neuroma contains increased levels of semaphorin 3A, which surrounds nerve fibers and reduces neurite extension in vitro
    Martijn R Tannemaat
    Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, An Institute of the Royal Academy of Arts and Sciences, 1105 BA Amsterdam, The Netherlands
    J Neurosci 27:14260-4. 2007
    ..to increased neurite outgrowth of F11 cells cultured on neuroma tissue, but not of F11 cells cultured on normal nerve tissue. These findings demonstrate the putative inhibitory role of sema3A in human neuroma tissue...
  78. pmc Differential global and extra-cellular matrix focused gene expression patterns between normal and glaucomatous human lamina cribrosa cells
    Ruaidhri P Kirwan
    Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
    Mol Vis 15:76-88. 2009
    ..We report the first study of global and ECM-focused gene transcription differentials between GFAP-negative lamina cribrosa (LC) cells from normal and POAG human donors...
  79. ncbi Effect of low-intensity pulsed ultrasound on the expression of neurotrophin-3 and brain-derived neurotrophic factor in cultured Schwann cells
    Hua Zhang
    Department of Orthopaedics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
    Microsurgery 29:479-85. 2009
    It is generally known that low-intensity pulsed ultrasound (LIPUS) accelerates peripheral nerve tissue regeneration. However, the precise cellular mechanism involved is still unclear...
  80. ncbi Intraorbital optic nerve stimulation with penetrating electrodes: in vivo electrophysiology study in rabbits
    Liming Li
    Institute for Laser Medicine and Bio Photonics, Department of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, 200240, China
    Graefes Arch Clin Exp Ophthalmol 247:349-61. 2009
    ..To investigate the response properties of the electrically evoked potentials (EEPs) elicited by intraorbital optic nerve stimulation with penetrating electrodes using different stimulus parameters...
  81. ncbi Molecular cloning and pharmacological characterization of a Bombyx mori tyramine receptor selectively coupled to intracellular calcium mobilization
    Jia Huang
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan
    Insect Biochem Mol Biol 39:842-9. 2009
    ..cDNA encoding the TA receptor (TAR) BmTAR2 was cloned from the nerve tissue of the silkworm Bombyx mori...
  82. ncbi Chondroitinase ABC (pharmaceutical grade) for chemonucleolysis. Functional and structural evaluation after local application on intraspinal nerve structures and blood vessels
    K Olmarker
    Department of Orthopaedics, Sahlgren University Hospital, Gothenburg, Sweden, USA
    Spine (Phila Pa 1976) 21:1952-6. 1996
    The effects on nerve tissue and blood vessels of locally applied chondroitinase ABC were studied in two experimental models using chymopapain and the vehicle of chondroitinase ABC for controls.
  83. ncbi [Effects of neurotrophic factor 3 gene modified SC on sciatic nerve regeneration in rats]
    Yuzhen Dong
    Department of Orthopedics, The First Affiliated Hospital of Xinxiang Medical College, Weihui Henan, 453100, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 23:1104-9. 2009
    ..To investgate the effects of neurotrophic factor 3 (NT-3) genes modified SC on facilitating nerve regeneration and protecting neuronal survival after the sciatic nerve transection in rats...
  84. ncbi Myelin formation by Schwann cells in the absence of beta4 integrin
    R Frei
    Department of Neurology, Section of Developmental Neurobiology, University of Wurzburg, Wurzburg, Germany
    Glia 27:269-74. 1999
    ..e., in peripheral nerve tissue from beta4 integrin-deficient mice...
  85. ncbi Nerve fibers in uterosacral ligaments of women with deep infiltrating endometriosis
    Adolpho Roberto Kelm Junior
    Ob Gyn Department, Santa Casa Medical School, Sao Paulo, Brazil
    J Reprod Immunol 79:93-9. 2008
    Endometriosis is a disease of high prevalence and enigmatic origin. One aspect not yet clarified is the relationship between endometriosis and nerve tissue.
  86. ncbi Regulation of human glutamate dehydrogenases: implications for glutamate, ammonia and energy metabolism in brain
    A Plaitakis
    Department of Neurology, School of Health Sciences, Section of Medicine, University of Crete, Heraklion, Crete, Greece
    J Neurosci Res 66:899-908. 2001
    ..human, GDH exists in heat-resistant and heat-labile isoforms, encoded by the GLUD1 (housekeeping) and GLUD2 (nerve tissue-specific) genes, respectively. These forms differ in their catalytic and allosteric properties...
  87. ncbi Repulsive axon guidance molecule Sema3A inhibits branching morphogenesis of fetal mouse lung
    T Ito
    Department of Pathology, Yokohama City University School of Medicine, 3 9 Fuku ura, Kanazawa Ku, 236 0004, Yokohama, Japan
    Mech Dev 97:35-45. 2000
    ..CRMP (CRMP-2), an intracellular protein mediating Sema3A signaling, was localized in alveolar epithelial cells, nerve tissue and airway neuroendocrine cells...
  88. ncbi Rudolf Virchow and presentation of his scientific achievement in Polish medical magazines in the 19th century and the beginning of 20th century
    Daniel Sabat
    Department of Pathomorphology, Medical Faculty in Zabrze, Silesian Academy of Medicine, Katowice
    Pol J Pathol 53:163-8. 2002
    ..Also a translation of the XI chapter of "Cellular pathology..." devoted to nerve tissue appeared in the same magazine...
  89. ncbi Assessing the effects of three dental impression materials on the isolated sciatic nerve of rat and frog
    A Andreou
    Laboratory of Animal Physiology, School of Biology, Aristotle University, Thessaloniki 54124, Hellas, Greece
    Toxicol In Vitro 21:103-8. 2007
    The effects on nerve tissue of three dental impression pastes were compared in this study. Two of the impression pastes, Examix and Express 3M, contained vinyl polysiloxane while the other, Xanthopren, did not...
  90. ncbi Cholestanol metabolism in patients with cerebrotendinous xanthomatosis: absorption, turnover, and tissue deposition
    Ashim K Bhattacharyya
    Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    J Lipid Res 48:185-92. 2007
    ..0 in plasma and liver to 30.0 in the cerebellar xanthoma; cholestanol was especially high in nerve tissue. Our data indicate that CTX patients absorb cholestanol from the diet...
  91. ncbi Molecular cloning and heterologous expression of an alpha-adrenergic-like octopamine receptor from the silkworm Bombyx mori
    A Ohtani
    Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Shimane, Japan
    Insect Mol Biol 15:763-72. 2006
    A cDNA encoding an octopamine (OA) receptor (BmOAR1) was isolated from the nerve tissue of silkworm (Bombyx mori) larvae...
  92. ncbi Ablation of T cell immunity differentially influences tumor risk in inbred BD rat strains
    Judith A M Marx
    Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, Bonn, Germany
    Cancer Immunol Immunother 58:1287-95. 2009
    ..Initially considerable amounts of Neu/ErbB-2-mutant cells arise in nerve tissue of both rat strains subsequently disappearing in resistant BDIV rats, but persisting and giving rise to MPNST ..
  93. pmc Anatomical distribution of avian bornavirus in parrots, its occurrence in clinically healthy birds and ABV-antibody detection
    Michael Lierz
    Institute for Poultry Diseases, Freie Universitaet Berlin, Germany
    Avian Pathol 38:491-6. 2009
    ..Viraemia was observed in a PDD-affected bird whereas a restriction of ABV to nerve tissue was found in the non-PDD-affected bird...
  94. ncbi Serotonin receptor subtype mRNA expression in human ocular tissues, determined by RT-PCR
    Najam A Sharif
    Ophthalmology Discovery Research, Alcon Research, Ltd, Fort Worth, TX 76134, USA
    Mol Vis 12:1040-7. 2006
    ..To determine the relative density and tissue localization of mRNAs for serotonin (5-hydroxytryptamine; 5HT) receptor subtypes in human ocular tissues and correlate with their possible functions in the eye...
  95. ncbi Co-infection with two different Campylobacter jejuni strains in a patient with the Guillain-Barré syndrome
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Microbes Infect 8:248-53. 2006
    ..molecular mimicry between bacterial sialylated lipo-oligosaccharides (LOS) and gangliosides in peripheral nerve tissue. We investigated whether co-infections with multiple C...
  96. ncbi Histological considerations of the cleavage plane for preservation of facial and cochlear nerve functions in vestibular schwannoma surgery
    Tomio Sasaki
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurosurg 110:648-55. 2009
    ..The authors analyzed the tumor capsule and the tumor-nerve interface in vestibular schwannomas (VSs) to define the ideal cleavage plane for maximal tumor removal with preservation of facial and cochlear nerve functions...
  97. ncbi Tissue distribution and deposition of clofazimine in mice following oral administration with or without isoniazid
    Krishnamurthy Venkatesan
    National JALMA Institute for Leprosy and Other Mycobacterial Diseases ICMR, Agra, India
    Arzneimittelforschung 57:472-4. 2007
    ..1-42.8 microg/g of wet tissue). There was a significant amount of the drug in foot pads and pooled nerve tissue showed detectable amount of the drug. The plasma concentrations in all treated groups were in the range of 0...
  98. ncbi Detection of genomic viral RNA in nerve and muscle of patients with HCV neuropathy
    F J Authier
    Groupe Nerf Muscle, Departement de Pathologie, Hopital Henri Mondor, Creteil, France
    Neurology 60:808-12. 2003
    ..MC may contain viral RNA, and tissues showing vasculitis may contain intracellular HCV. Local HCV replication remains to be evidenced...
  99. ncbi First single movement of turkey embryos
    Diedrich Graf von Keyserlingk
    Department of Histology and Embryology, Kaunas University of Medicine, Kaunas, Lithuania
    Medicina (Kaunas) 41:592-602. 2005
    ..The space of time of the contraction since beginning of incubation, topography, morphogenesis and histology of the concerned muscle and its mechanical counterpart are described...
  100. ncbi Magnesium supplement promotes sciatic nerve regeneration and down-regulates inflammatory response
    Hung Chuan Pan
    Department of Neurosurgery, Taichung Veterans General Hospital, Taichung, Taiwan
    Magnes Res 24:54-70. 2011
    ..First, a high Mg diet significantly increased plasma and nerve tissue Mg concentrations...
  101. ncbi Current recommendations for the prophylaxis and treatment of rabies
    D W Dreesen
    Department of Medical Microbiology, University of Georgia, Athens, USA
    Drugs 56:801-9. 1998
    ..b>Nerve tissue origin vaccines, although used extensively in some parts of the world, are not recommended if cell or tissue ..

Research Grants52

  1. NMR Studies of Plasminogen and Related Genomic Domains
    Miguel Llinas; Fiscal Year: 2004
    ..Functional in nerve tissue extension are various transmembrane protein tyrosine kinase receptors which contain kringle and frizzled (..
  2. Ribosomal Protein Gene Silencing in Neural Crest Stem Cells
    JOHNSON MING YU LIU; Fiscal Year: 2010
    ..is a specialized population of stem cells that generates most of the bone, cartilage, connective and peripheral nerve tissue in the head in the developing embryo, and abnormalities in the neural crest can lead to craniofacial defects ..
  3. Protein Acetylation in Glaucomatous Optic Neuropathy
    Craig E Crosson; Fiscal Year: 2013
    ..shown that HDACs play a central role in modulating expression and secretion of TNF-[unreadable] from the optic nerve tissue, and block the cytokine-induced expression of matrix metalloproteinases (MMPs)...
  4. Recurrent laryngeal nerve connective tissues as a factor in vocal fold paralysis
    Julie M Barkmeier-Kraemer; Fiscal Year: 2013
    ..e. idiopathic). Surgical etiology of UVP is associated with nerve or nerve tissue damage suffered during or possibly after surgery...
  5. Early Detection of Glaucoma Using Raman Spectroscopy
    Tatjana Lazic; Fiscal Year: 2012
    ..spectroscopy can be effectively used for detection of early biochemical changes in canine retina and optic nerve tissue sections after induction of compressive optic neuropathy or acute elevation of intraocular pressure;4) A unique ..
  6. In Vivo Control and Functional Visualization of Stem Cell-Driven CNS Regeneration
    Jin Hyung Lee; Fiscal Year: 2010
    ..This project, upon its success, will provide direct functional assessment capabilities for the regenerated nerve tissue in vivo. This in turn will provide key guidance for developing novel stem cell therapies for CNS diseases...
  7. Cellular events in heritable peripheral neuropathies
    Lucia Notterpek; Fiscal Year: 2013
    ..Since cytosolic PMP22 is only detected in nerve tissue from neuropathic and not normal mice, the abnormal intracellular accumulation of PMP22 likely contributes to ..
  8. Testing Fluorescently Labeled Probes for Nerve Imaging during Surgery
    Quyen Nguyen; Fiscal Year: 2013
    ..Peptide 41 (NP41) through phage display that preferentially binds to peripheral nerves compared to adjacent non-nerve tissue after systemic administration...
  9. Craniofacial Development and Disease
    Paul A Trainor; Fiscal Year: 2013
    ..neural crest cells alive and also how neural crest cells decide to become cartilage or bone of connective and nerve tissue. In this proposal we study a mouse model of Treacher Collins syndrome, which replicates the severe craniofacial ..
  10. Local Anesthetic Interactions with Membranes
    Gary Strichartz; Fiscal Year: 2005
    ..membranes, where transport more closely resembles the passage of drugs across the barriers ensheathing nerve tissue. Novel spectrofluorometric methods will be applied to determine partition coefficients, the depth of membrane ..
  11. AVERMECTIN, TETRODOTOXIN, & RADICAL-ALDEHYDE CYCLIZATION
    Bert Fraser Reid; Fiscal Year: 1991
    ..unique biological activity in that it is specific for the identification and use of sodium ion channels in nerve tissue. However, current availability relies almost exclusively on isolation form the puffer fish...
  12. Linear-Dendritic Copolymers as Tissue Growth Scaffolds
    TIMOTHY PATTEN; Fiscal Year: 2005
    ..These materials would be applied to nerve tissue culture, which would impact treatments for nerve tissue disorders, such as Parkinson's disease or spinal chord ..
  13. Advanced Molecular Diagnostic Test for Neurofibromatosis
    Mark Lim; Fiscal Year: 2009
    ..children, NF1 causes learning disabilities, coordination problems and benign tumors later in life that grow on nerve tissue. Currently more than 100,000 Americans suffer from NF1 with the disease having one of the highest prevalence ..
  14. CONNEXIN32 MUTATIONS IN CHARCOT-MARIE-TOOTH-X DISEASE
    LINDA MUSIL; Fiscal Year: 2004
    ..These studies will be conducted in transfected tissue culture cells as well as in peripheral nerve tissue from mice expressing Cx32 mutants...
  15. Neurotrophic LCP Plastic Substrate Nerve Electrode Array
    Brian Farrell; Fiscal Year: 2003
    ..mass produced, inexpensive, neurotrophic electrodes that can be used for exchanging information with central nerve tissue. Neurotrophic electrodes are designed to record from individual or multiple axon potentials recorded across a ..
  16. CONFOCAL LASER DOPPLER FLOWMETRY IN THE OPTIC NERVE
    ANDREAS DREHER; Fiscal Year: 1999
    ..One of the hypotheses for the cause of glaucoma is that the optic nerve tissue is damaged by insufficient blood flow, because of a deficiency in the tissue's ability to regulate its own ..
  17. EFFECT OF ELF EM FIELD FREQUENCY ON NEURITE OUTGROWTH
    James Ryaby; Fiscal Year: 1993
    ..fields (PEMFs) have been shown to enhance regeneration of central nervous system (CNS) and peripheral nerve tissue both in vitro and in vivo...
  18. PROPERTIES OF AXON TO GLIA GLUTAMATE SIGNALING
    EDWARD LIEBERMAN; Fiscal Year: 1999
    ..that are proposed to maintain potassium homeostasis for preservation of neuronal excitability, and to influence nerve tissue metabolism, growth, and differentiation...
  19. Placebo Cntrld db PH.ll/lll stdy Fx-1006A trtmnt fam Amyloid Polyneuropathy
    JEFFREY PACKMAN; Fiscal Year: 2009
    ..Deposition of amyloid fibrils of variant transthyretin (TTR) (primarily V30M) in peripheral nerve tissue produces the condition called FAP. Mutation in TTR destabilizes the protein and causes amyloid deposition...
  20. Analysis & Control of Non-Synaptic Epileptiform Activity
    Dominique Durand; Fiscal Year: 2004
    ..The results of our studies should provide valuable insight into mechanisms underlying epileptogenesis as well as new tools for the control and suppression of epileptic seizures. ..
  21. Functionalized Coatings for Enhanced Neural Interfaces
    Stuart Cogan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Contribution of ATGL in skeletal muscle to lipid metabolism and insulin action
    ERIN KERSHAW; Fiscal Year: 2008
    ..Evaluating the role of ATGL-mediated fat breakdown in skeletal muscle will provide important insights into the pathophysiology and treatment of obesity, insulin resistance, and related metabolic disorders. [unreadable] [unreadable]..
  23. MODEL FOR ELECTRODE TESTING AND REDUCED ANIMAL USE
    Stuart Cogan; Fiscal Year: 2003
    ..The validity of the inanimate and living models will be evaluated by comparison of electrode function in the in vitro models with that observed under identical test protocols in the chronic cat cortex. ..
  24. Local Body Composition Measurement by Magnetic Induction
    Stephen Norton; Fiscal Year: 2002
    ..abstract_text> ..
  25. MOLECULAR MECHANISMS OF HEXACARBON-INDUCED AXON ATROPHY
    RICHARD LOPACHIN; Fiscal Year: 2009
    ..Understanding the role and mechanism of axon atrophy in solvent neurotoxicity has broad-based implications for human occupational health and risk assessment. ..
  26. BRAIN STRUCTURE/FUNCTION IN OROFACIAL CLEFTING DISORDERS
    Peggy Nopoulos; Fiscal Year: 2003
    ..This award will also provide the candidate with the background necessary for ongoing research and funding leading to an independent research career. ..
  27. NOS-INDEPENDENT NO PRODUCTION IN THE NERVOUS SYSTEM
    Leonid Moroz; Fiscal Year: 2002
    ..Thus, significant gains can be made in our understanding of the synthesis of this gaseous messenger in the brain. This work will also contribute to our understanding of the neural functions in normal and pathological conditions. ..
  28. REGIONAL PATTERNING IN THE VENTRAL TELENCEPHALON
    GORDON J FISHELL; Fiscal Year: 2010
    ..If we can understand how this population is generated, we will take the first step towards assessing whether we can use gene or cell therapies to ameliorate the devasting consequences associated with cortical interneuron dysfunction. ..
  29. Electrodeposited Noble Metal Oxide Nerve Electrodes
    Stuart Cogan; Fiscal Year: 2006
    ..abstract_text> ..
  30. DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINA
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
  31. DYSREGULATION OF THE TAURINE TRANSPORTER IN DIABETES
    Martin Stevens; Fiscal Year: 2002
    ..As an alternative, if in aim 1 little correlation between hTT mRNA abundance and hTT activity is found, then glucose mediated post-translational modifications will be examined. ..
  32. CORTICOLIMBIC SYSTEM AND SCHIZOPHRENIA
    Francine Benes; Fiscal Year: 2002
    ....
  33. VASCULARIZATION IN TISSUE ENGINEERED CONSTRUCTS
    Charles Patrick; Fiscal Year: 2001
    ..does TEC-recipient inosculation play in TEC vascularization? (b) What are the biological functions of CD144, principally with regards to its role in inosculation and its regulation by the unique TEC microenvironment? ..
  34. Taurine and Painful Diabetic Neuropathy
    Martin Stevens; Fiscal Year: 2007
    ..These studies will test a novel mechanistically based therapeutic approach to a common disabling and often-refractory complication of diabetes. ..
  35. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
    ....
  36. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  37. 3D Adipose Tissue Generation and Functional Verification
    Charles Patrick; Fiscal Year: 2004
    ..abstract_text> ..
  38. CHRONIC CENTRAL PAIN IN SPINAL CORD INJURY
    CLAIRE HULSEBOSCH; Fiscal Year: 2005
    ..There are three cores: an administrative core, an animal core and a morphology core. The results for these studies will guide the development of strategic interventions to improve functional outcome after SCI. ..
  39. Effects of VEGF on Brain Tissue in vitro
    JEFFREY ROSENSTEIN; Fiscal Year: 2004
    ..The results can lay important cell biological groundwork for understanding how brain tissue might respond to VEGF-based therapy. ..
  40. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
  41. Hyperglycemia-Induced Mechanical Hyperalgesia
    Maxim Dobretsov; Fiscal Year: 2006
    ..abstract_text> ..
  42. Mechanisms of VEGF Action in Intact and Grafted CNS
    JEFFREY ROSENSTEIN; Fiscal Year: 2006
    ..These studies may provide impetus for the further design strategies for the circumvention of the BBB and/or the targeting of VEGF receptor mediated effects in brain injury. [unreadable] [unreadable]..
  43. ACTIVATION OF TONGUE MUSCLES IN OBSTRUCTIVE SLEEP APNEA
    Dominique Durand; Fiscal Year: 2004
    ..It is anticipated that the experimental delineation and validation of these methods will lead to a design of a neuroprosthetic device for the treatment of OSA. ..
  44. MUSCARINIC RECEPTOR COUPLING TO INOSITIDES IN CNS
    Stephen Fisher; Fiscal Year: 2006
    ..Accordingly, knowledge of the signal transduction pathways that regulate VSOAC is an essential prerequisite for the rational design of therapeutic agents. ..
  45. Cognitive Effects of Cerebellar Lesions in Humans
    JEREMY SCHMAHMANN; Fiscal Year: 2006
    ..This study has implications for the recognition and treatment of disorders of higher order function in cerebellar patients. [unreadable] [unreadable]..
  46. PACING, SENSING AND DEFIBRILLATION ELECTRODE COATINGS
    Stuart Cogan; Fiscal Year: 2006
    ..The in vivo studies will be done with collaborators at the University of Alabama. [unreadable] [unreadable]..
  47. Conductive Polymer Recording and Stimulation Electrodes
    Stuart Cogan; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  48. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  49. MECHANISMS OF NEURAL PATTERNING IN MAMMALIAN FOREBRAIN
    Gordon Fishell; Fiscal Year: 2007
    ..abstract_text> ..
  50. LIFE AND DEATH OF RETINAL GANGLION CELLS
    Vittorio Porciatti; Fiscal Year: 2007
    ..Such outcomes are significant, since exploiting an animal model for testing neuroprotective strategies that preserve visual function is an important component of future research on treatments for glaucoma. ..
  51. Matrix metalloproteinases as biomarkers of neurodegeneration
    Veronica Shubayev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..