nerve net

Summary

Summary: A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.

Top Publications

  1. ncbi Collective dynamics of 'small-world' networks
    D J Watts
    Department of Theoretical and Applied Mechanics, Cornell University, Ithaca, New York 14853, USA
    Nature 393:440-2. 1998
  2. ncbi Complex network measures of brain connectivity: uses and interpretations
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    Neuroimage 52:1059-69. 2010
  3. ncbi Complex brain networks: graph theoretical analysis of structural and functional systems
    Ed Bullmore
    University of Cambridge, Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Nat Rev Neurosci 10:186-98. 2009
  4. ncbi The brain's default network: anatomy, function, and relevance to disease
    Randy L Buckner
    Department of Psychology, Harvard University, William James Hall, 33 Kirkland Drive, Cambridge, MA 02148, USA
    Ann N Y Acad Sci 1124:1-38. 2008
  5. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
  6. ncbi Neuronal oscillations in cortical networks
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, Newark, NJ 07102, USA
    Science 304:1926-9. 2004
  7. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
  8. pmc Mapping the structural core of human cerebral cortex
    Patric Hagmann
    Department of Radiology, University Hospital Center and University of Lausanne CHUV, Lausanne, Switzerland
    PLoS Biol 6:e159. 2008
  9. pmc The reorienting system of the human brain: from environment to theory of mind
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 58:306-24. 2008
  10. pmc Correspondence of the brain's functional architecture during activation and rest
    Stephen M Smith
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:13040-5. 2009

Detail Information

Publications301 found, 100 shown here

  1. ncbi Collective dynamics of 'small-world' networks
    D J Watts
    Department of Theoretical and Applied Mechanics, Cornell University, Ithaca, New York 14853, USA
    Nature 393:440-2. 1998
    ..In particular, infectious diseases spread more easily in small-world networks than in regular lattices...
  2. ncbi Complex network measures of brain connectivity: uses and interpretations
    Mikail Rubinov
    Black Dog Institute and School of Psychiatry, University of New South Wales, Sydney, Australia
    Neuroimage 52:1059-69. 2010
    ..Finally, we describe a Matlab toolbox (http://www.brain-connectivity-toolbox.net) accompanying this article and containing a collection of complex network measures and large-scale neuroanatomical connectivity datasets...
  3. ncbi Complex brain networks: graph theoretical analysis of structural and functional systems
    Ed Bullmore
    University of Cambridge, Behavioural and Clinical Neurosciences Institute, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, CB2 2QQ, UK
    Nat Rev Neurosci 10:186-98. 2009
    ..We also highlight some of the technical challenges and key questions to be addressed by future developments in this rapidly moving field...
  4. ncbi The brain's default network: anatomy, function, and relevance to disease
    Randy L Buckner
    Department of Psychology, Harvard University, William James Hall, 33 Kirkland Drive, Cambridge, MA 02148, USA
    Ann N Y Acad Sci 1124:1-38. 2008
    ..We conclude by discussing the relevance of the default network for understanding mental disorders including autism, schizophrenia, and Alzheimer's disease...
  5. pmc Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
    Michael D Greicius
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 100:253-8. 2003
    ..Our findings also provide insight into how this network is modulated by task demands and what functions it might subserve...
  6. ncbi Neuronal oscillations in cortical networks
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, State University of New Jersey, Newark, NJ 07102, USA
    Science 304:1926-9. 2004
    ....
  7. pmc Dissociable intrinsic connectivity networks for salience processing and executive control
    William W Seeley
    Department of Neurology, School of Medicine, University of California, San Francisco, San Francisco, California 94143, USA
    J Neurosci 27:2349-56. 2007
    ..Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior...
  8. pmc Mapping the structural core of human cerebral cortex
    Patric Hagmann
    Department of Radiology, University Hospital Center and University of Lausanne CHUV, Lausanne, Switzerland
    PLoS Biol 6:e159. 2008
    ..The spatial and topological centrality of the core within cortex suggests an important role in functional integration...
  9. pmc The reorienting system of the human brain: from environment to theory of mind
    Maurizio Corbetta
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuron 58:306-24. 2008
    ....
  10. pmc Correspondence of the brain's functional architecture during activation and rest
    Stephen M Smith
    Centre for Functional MRI of the Brain, University of Oxford, Oxford OX3 9DU, United Kingdom
    Proc Natl Acad Sci U S A 106:13040-5. 2009
    ..We conclude that the full repertoire of functional networks utilized by the brain in action is continuously and dynamically "active" even when at "rest."..
  11. pmc Default-mode network activity distinguishes Alzheimer's disease from healthy aging: evidence from functional MRI
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Proc Natl Acad Sci U S A 101:4637-42. 2004
    ..Finally, a goodness-of-fit analysis applied at the individual subject level suggests that activity in the default-mode network may ultimately prove a sensitive and specific biomarker for incipient AD...
  12. ncbi A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs
    Sophie Achard
    Wolfson Brain Imaging Centre, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge CB2 2QQ, United Kingdom
    J Neurosci 26:63-72. 2006
    ..Because the major hubs of this network are critical for cognition, its slow dynamics could provide a physiological substrate for segregated and distributed information processing...
  13. pmc Community structure in social and biological networks
    M Girvan
    Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA
    Proc Natl Acad Sci U S A 99:7821-6. 2002
    ..We also apply the method to two networks whose community structure is not well known--a collaboration network and a food web--and find that it detects significant and informative community divisions in both cases...
  14. pmc Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease
    Randy L Buckner
    Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 29:1860-73. 2009
    ....
  15. ncbi The brainweb: phase synchronization and large-scale integration
    F Varela
    Laboratoire de Neurosciences Cognitives et Imagerie Cerebrale, Hopital de la Salpetriere, Paris 47 Boulevard de l Hôpital, 75651 Paris Cedex 13, France
    Nat Rev Neurosci 2:229-39. 2001
    ..Although the mechanisms involved in large-scale integration are still largely unknown, we argue that the most plausible candidate is the formation of dynamic links mediated by synchrony over multiple frequency bands...
  16. ncbi The economy of brain network organization
    Ed Bullmore
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Department of Psychiatry, Cambridge Biomedical Campus, Cambridge CB2 0SZ, UK
    Nat Rev Neurosci 13:336-49. 2012
    ..An economical analysis of neuropsychiatric disorders highlights the vulnerability of the more costly elements of brain networks to pathological attack or abnormal development...
  17. pmc Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies
    Jeffrey R Binder
    Language Imaging Laboratory, Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cereb Cortex 19:2767-96. 2009
    ....
  18. ncbi Interneurons of the neocortical inhibitory system
    Henry Markram
    Laboratory of Neural Microcircuitry, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    Nat Rev Neurosci 5:793-807. 2004
    ..The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits...
  19. ncbi The mirror-neuron system
    Giacomo Rizzolatti
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Via Volturno, 3, Universita di Parma 43100, Parma, Italy
    Annu Rev Neurosci 27:169-92. 2004
    ..We stress, in particular, those properties specific to the human mirror-neuron system that might explain the human capacity to learn by imitation. We conclude by discussing the relationship between the mirror-neuron system and language...
  20. ncbi Network motifs: simple building blocks of complex networks
    R Milo
    Departments of Physics of Complex Systems and Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel 76100
    Science 298:824-7. 2002
    ..Motifs may thus define universal classes of networks. This approach may uncover the basic building blocks of most networks...
  21. pmc Efficiency and cost of economical brain functional networks
    Sophie Achard
    Brain Mapping Unit, Department of Psychiatry, Addenbrooke s Hospital, University of Cambridge, Cambridge, United Kingdom
    PLoS Comput Biol 3:e17. 2007
    ....
  22. pmc The organization of the human cerebral cortex estimated by intrinsic functional connectivity
    B T Thomas Yeo
    Harvard University, Department of Psychology, Center for Brain Science, Cambridge, MA 02138, USA
    J Neurophysiol 106:1125-65. 2011
    ..We conclude by discussing the organization of these large-scale cerebral networks in relation to monkey anatomy and their potential evolutionary expansion in humans to support cognition...
  23. ncbi Organization, development and function of complex brain networks
    Olaf Sporns
    Department of Psychology and Programs in Cognitive and Neural Science, Indiana University, Bloomington, IN 47405, USA
    Trends Cogn Sci 8:418-25. 2004
    ..We suggest that network analysis offers new fundamental insights into global and integrative aspects of brain function, including the origin of flexible and coherent cognitive states within the neural architecture...
  24. ncbi A mechanism for cognitive dynamics: neuronal communication through neuronal coherence
    Pascal Fries
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Trends Cogn Sci 9:474-80. 2005
    ..Thus, a flexible pattern of coherence defines a flexible communication structure, which subserves our cognitive flexibility...
  25. pmc The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?
    Kevin Murphy
    Section on Functional Imaging Methods, National Institute of Mental Health, Bethesda, MD 20892 1148, USA
    Neuroimage 44:893-905. 2009
    ..These results call into question the interpretation of negatively correlated regions in the brain when using global signal regression as an initial processing step...
  26. pmc Network anatomy and in vivo physiology of visual cortical neurons
    Davi D Bock
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:177-82. 2011
    ....
  27. pmc Functional network organization of the human brain
    Jonathan D Power
    Department of Neurology, Washington University in Saint Louis, St Louis, MO 63130, USA
    Neuron 72:665-78. 2011
    ..The modified voxelwise graph also reveals spatial motifs in the patterning of systems across the cortex...
  28. pmc Distinct brain networks for adaptive and stable task control in humans
    Nico U F Dosenbach
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:11073-8. 2007
    ..These two independent networks appear to operate on different time scales and affect downstream processing via dissociable mechanisms...
  29. ncbi Network modelling methods for FMRI
    Stephen M Smith
    FMRIB Oxford University Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, Oxford, UK
    Neuroimage 54:875-91. 2011
    ....
  30. pmc Neurophysiological and computational principles of cortical rhythms in cognition
    Xiao Jing Wang
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Physiol Rev 90:1195-268. 2010
    ..Finally, implications of abnormal neural synchronization are discussed as they relate to mental disorders like schizophrenia and autism...
  31. pmc A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks
    Devarajan Sridharan
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:12569-74. 2008
    ..Our findings have important implications for a unified view of network mechanisms underlying both exogenous and endogenous cognitive control...
  32. ncbi Rich-club organization of the human connectome
    Martijn P van den Heuvel
    Department of Psychiatry, University Medical Center Utrecht, Rudolf Magnus Institute of Neuroscience, 3508 GA Utrecht, The Netherlands
    J Neurosci 31:15775-86. 2011
    ..We discuss the potential functional implications of the rich-club organization of the human connectome, particularly in light of its role in information integration and in conferring robustness to its structural core...
  33. ncbi Emerging concepts for the dynamical organization of resting-state activity in the brain
    Gustavo Deco
    Institucio Catalana de Recerca i Estudis Avancats, Universitat Pompeu Fabra, Computational Neuroscience, Plaça de la Mercè, 10 12, 08002 Barcelona, Spain
    Nat Rev Neurosci 12:43-56. 2011
    ..We propose that the formation and dissolution of resting-state patterns reflects the exploration of possible functional network configurations around a stable anatomical skeleton...
  34. ncbi Neurophysiological architecture of functional magnetic resonance images of human brain
    Raymond Salvador
    Brain Mapping Unit and Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Cereb Cortex 15:1332-42. 2005
    ....
  35. pmc Resting-state functional connectivity reflects structural connectivity in the default mode network
    Michael D Greicius
    Department of Neurology, Stanford University School of Medicine, Stanford, CA 94304, USA
    Cereb Cortex 19:72-8. 2009
    ..The results demonstrate that resting-state functional connectivity reflects structural connectivity and that combining modalities can enrich our understanding of these canonical brain networks...
  36. ncbi Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
    ..The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior...
  37. ncbi Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks
    Marlene Bartos
    Physiologisches Institut der Universität Freiburg, Abteilung 1, Hermann Herder Strasse 7, D 79104 Freiburg, Germany
    Nat Rev Neurosci 8:45-56. 2007
    ..Computational analysis further suggests that synaptic specialization turns interneuron networks into robust gamma frequency oscillators...
  38. ncbi Self-referential processing in our brain--a meta-analysis of imaging studies on the self
    Georg Northoff
    Department of Neurology, Harvard University, Cambridge, MA 02138, USA
    Neuroimage 31:440-57. 2006
    ..We conclude that self-referential processing in CMS constitutes the core of our self and is critical for elaborating experiential feelings of self, uniting several distinct concepts evident in current neuroscience...
  39. pmc A synaptic organizing principle for cortical neuronal groups
    Rodrigo Perin
    Blue Brain Project, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    Proc Natl Acad Sci U S A 108:5419-24. 2011
    ..We speculate that these elementary neuronal groups are prescribed Lego-like building blocks of perception and that acquired memory relies more on combining these elementary assemblies into higher-order constructs...
  40. pmc Brain-wide neuronal dynamics during motor adaptation in zebrafish
    Misha B Ahrens
    Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nature 485:471-7. 2012
    ..Lesions to the inferior olive indicate a specific functional role for olivocerebellar circuitry in adaptive locomotion. This study enables the analysis of brain-wide dynamics at single-cell resolution during behaviour...
  41. pmc Wandering minds: the default network and stimulus-independent thought
    Malia F Mason
    Department of Psychological and Brain Sciences, Dartmouth College, Hanover, NH 03755, USA
    Science 315:393-5. 2007
    ..In addition, individuals' reports of the tendency of their minds to wander were correlated with activity in this network...
  42. ncbi Small-world anatomical networks in the human brain revealed by cortical thickness from MRI
    Yong He
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, Canada
    Cereb Cortex 17:2407-19. 2007
    ..To our knowledge, this study provides the first report of small-world properties and degree distribution of anatomical networks in the human brain using cortical thickness measurements...
  43. pmc Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression
    Wayne C Drevets
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, National Institutes of Health NIH NIMH DIRP, 15K North Dr, Room 210, Bethesda, MD 20892, USA
    Brain Struct Funct 213:93-118. 2008
    ..This paper discusses these systems together with the neurochemical systems that impinge on them and form the basis for most pharmacological therapies...
  44. pmc Mapping anatomical connectivity patterns of human cerebral cortex using in vivo diffusion tensor imaging tractography
    Gaolang Gong
    Department of Biomedical Engineering, 1098 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada
    Cereb Cortex 19:524-36. 2009
    ..Our results are compatible with previous structural and functional brain networks studies and provide insight into the organizational principles of human brain anatomical networks that underlie functional states...
  45. pmc The maturing architecture of the brain's default network
    Damien A Fair
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:4028-32. 2008
    ..We found that the default regions are only sparsely functionally connected at early school age (7-9 years old); over development, these regions integrate into a cohesive, interconnected network...
  46. ncbi Neuronal circuits of the neocortex
    Rodney J Douglas
    Institute of Neuroinformatics, University ETH Zurich, Zurich 8057, Switzerland
    Annu Rev Neurosci 27:419-51. 2004
    ....
  47. ncbi Neuronal avalanches in neocortical circuits
    John M Beggs
    Unit of Neural Network Physiology, Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 4075, USA
    J Neurosci 23:11167-77. 2003
    ..In the critical state, the network may satisfy the competing demands of information transmission and network stability...
  48. ncbi Neural correlations, population coding and computation
    Bruno B Averbeck
    Department of Brain and Cognitive Sciences and Center for Visual Science, University of Rochester, Rochester, New York 14627, USA
    Nat Rev Neurosci 7:358-66. 2006
    ..Here, we review studies that address the interaction between neuronal noise and population codes, and discuss their implications for population coding in general...
  49. ncbi Functional and effective connectivity: a review
    Karl J Friston
    The Wellcome Trust Centre for Neuroimaging, University College London, London, United Kingdom
    Brain Connect 1:13-36. 2011
    ..I accepted the invitation to write this review with great pleasure and hope to celebrate and critique the achievements to date, while addressing the challenges ahead...
  50. ncbi How do you feel? Interoception: the sense of the physiological condition of the body
    A D Craig
    Nat Rev Neurosci 3:655-66. 2002
    ..This system constitutes a representation of 'the material me', and might provide a foundation for subjective feelings, emotion and self-awareness...
  51. pmc Functional specificity of local synaptic connections in neocortical networks
    Ho Ko
    Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Nature 473:87-91. 2011
    ..Our results reveal the degree of functional specificity of local synaptic connections in the visual cortex, and point to the existence of fine-scale subnetworks dedicated to processing related sensory information...
  52. ncbi fMRI resting state networks define distinct modes of long-distance interactions in the human brain
    M De Luca
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain, UK
    Neuroimage 29:1359-67. 2006
    ..Because RSNs reflect interactions in cognitively relevant functional networks, they offer a new approach to the characterization of state changes with pathology and the effects of drugs...
  53. pmc Serial block-face scanning electron microscopy to reconstruct three-dimensional tissue nanostructure
    Winfried Denk
    Max Planck Institute for Medical Research, Heidelberg, Germany
    PLoS Biol 2:e329. 2004
    ..This opens the possibility of automatically obtaining the electron-microscope-level 3D datasets needed to completely reconstruct the connectivity of neuronal circuits...
  54. ncbi Cortical inhibitory neurons and schizophrenia
    David A Lewis
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Nat Rev Neurosci 6:312-24. 2005
    ..These findings reveal specific targets for therapeutic interventions to improve cognitive function in individuals with schizophrenia...
  55. ncbi Experience-dependent structural synaptic plasticity in the mammalian brain
    Anthony Holtmaat
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Switzerland
    Nat Rev Neurosci 10:647-58. 2009
    ..This Review focuses on recent evidence for such structural forms of synaptic plasticity in the mammalian cortex and outlines open questions...
  56. pmc Functional connectivity and brain networks in schizophrenia
    Mary Ellen Lynall
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom
    J Neurosci 30:9477-87. 2010
    ....
  57. ncbi Small-world networks and functional connectivity in Alzheimer's disease
    C J Stam
    Department of Clinical Neurophysiology, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    Cereb Cortex 17:92-9. 2007
    ..Graph theoretical analysis may be a useful approach to study the complexity of patterns of interrelations between EEG channels...
  58. ncbi Decorrelated neuronal firing in cortical microcircuits
    Alexander S Ecker
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Science 327:584-7. 2010
    ..Our findings suggest a refinement of current models of cortical microcircuit architecture and function: Either adjacent neurons share only a few percent of their inputs or, alternatively, their activity is actively decorrelated...
  59. pmc Functional brain networks develop from a "local to distributed" organization
    Damien A Fair
    Behavioral Neuroscience Department, Oregon Health and Science University, Portland, OR, USA
    PLoS Comput Biol 5:e1000381. 2009
    ..These observations suggest that early school age children and adults both have relatively efficient systems that may solve similar information processing problems in divergent ways...
  60. ncbi The principal features and mechanisms of dopamine modulation in the prefrontal cortex
    Jeremy K Seamans
    Department of Physiology, MUSC, 173 Ashley Avenue, Suite 403, Charleston, SC 29425, USA
    Prog Neurobiol 74:1-58. 2004
    ..Based on these factors, a theory is proposed for DA's action in PFC. This theory suggests that DA acts to expand or contract the breadth of information held in working memory buffers in PFC networks...
  61. ncbi The human connectome: a complex network
    Olaf Sporns
    Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN 47405, USA
    Ann N Y Acad Sci 1224:109-25. 2011
    ..Future studies of the human connectome will greatly expand our knowledge of network topology and dynamics in the healthy, developing, aging, and diseased brain...
  62. pmc Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:11020-5. 2010
    ....
  63. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits...
  64. pmc Neurodegenerative diseases target large-scale human brain networks
    William W Seeley
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA
    Neuron 62:42-52. 2009
    ..Future studies may clarify how these complex systems are assembled during development and undermined by disease...
  65. ncbi Small-world brain networks
    Danielle Smith Bassett
    Brain Mapping Unit, University of Cambridge, Department of Psychiatry, Addenbrooke s Hospital, Cambridge, United Kingdom
    Neuroscientist 12:512-23. 2006
    ..They conclude that small-world models provide a powerful and versatile approach to understanding the structure and function of human brain systems...
  66. pmc Hyperactivity and hyperconnectivity of the default network in schizophrenia and in first-degree relatives of persons with schizophrenia
    Susan Whitfield-Gabrieli
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:1279-84. 2009
    ..Hyperactivation (reduced task-related suppression) of default regions and hyperconnectivity of the default network may contribute to disturbances of thought in schizophrenia and risk for the illness...
  67. pmc Functional-anatomic fractionation of the brain's default network
    Jessica R Andrews-Hanna
    Department of Psychology and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 65:550-62. 2010
    ..During certain experimentally directed and spontaneous acts of future-oriented thought, these dissociated components are simultaneously engaged, presumably to facilitate construction of mental models of personally significant events...
  68. ncbi Reduced resting-state brain activity in the "default network" in normal aging
    J S Damoiseaux
    Department of Neurology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands
    Cereb Cortex 18:1856-64. 2008
    ..The relevance of these findings is illustrated by the correlation between reduced activity of one of these RSNs and less effective executive functioning/processing speed in the older group...
  69. ncbi Frequencies contributing to functional connectivity in the cerebral cortex in "resting-state" data
    D Cordes
    Department of Medical Physics, University of Wisconsin at Madison, 1300 University Ave, 1530 MSC, Madison, WI 53706, USA
    AJNR Am J Neuroradiol 22:1326-33. 2001
    ..In functionally connected regions, these low frequencies are characterized by a high degree of temporal coherence...
  70. ncbi Disrupted brain connectivity networks in drug-naive, first-episode major depressive disorder
    Junran Zhang
    Huaxi Magnetic Resonance Research Center, Department of Radiology, Center for Medical Imaging, West China Hospital of Sichuan University, Chengdu, China
    Biol Psychiatry 70:334-42. 2011
    ....
  71. pmc The functional role of cross-frequency coupling
    Ryan T Canolty
    Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
    Trends Cogn Sci 14:506-15. 2010
    ....
  72. ncbi Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies
    Catherine J Stoodley
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuroimage 44:489-501. 2009
    ..Prospective studies of multiple domains within single individuals are necessary to better elucidate neurobehavioral structure-function correlations in the cerebellar posterior lobe...
  73. pmc The global signal and observed anticorrelated resting state brain networks
    Michael D Fox
    Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
    J Neurophysiol 101:3270-83. 2009
    ....
  74. ncbi Correlations and anticorrelations in resting-state functional connectivity MRI: a quantitative comparison of preprocessing strategies
    Andreas Weissenbacher
    MR Centre of Excellence, Medical University of Vienna, Vienna, Austria
    Neuroimage 47:1408-16. 2009
    ....
  75. ncbi Age-related changes in modular organization of human brain functional networks
    David Meunier
    Brain Mapping Unit, University of Cambridge, Cambridge, UK
    Neuroimage 44:715-23. 2009
    ....
  76. pmc Identification and classification of hubs in brain networks
    Olaf Sporns
    Department of Psychological and Brain Sciences and Program in Cognitive Science, Indiana University, Bloomington, Indiana, United States of America
    PLoS ONE 2:e1049. 2007
    ....
  77. pmc Development of distinct control networks through segregation and integration
    Damien A Fair
    Departments of Neurology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:13507-12. 2007
    ..Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome...
  78. ncbi Path integration and the neural basis of the 'cognitive map'
    Bruce L McNaughton
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, and Department of Psychology, University of Arizona, Tucson 85724, USA
    Nat Rev Neurosci 7:663-78. 2006
    ..Convergence of spatially periodic input at multiple scales, from so-called grid cells in the entorhinal cortex, might result in non-periodic spatial firing patterns (place fields) in the hippocampus...
  79. ncbi Structural insights into aberrant topological patterns of large-scale cortical networks in Alzheimer's disease
    Yong He
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 28:4756-66. 2008
    ..This work has implications for our understanding of how functional deficits in patients are associated with their underlying structural (morphological) basis...
  80. pmc Age- and gender-related differences in the cortical anatomical network
    Gaolang Gong
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    J Neurosci 29:15684-93. 2009
    ..There were also distributed regional differences in efficiency between sexes. Our results provide new insights into the substrates that underlie behavioral and cognitive differences in aging and sex...
  81. pmc Brain connectivity related to working memory performance
    Michelle Hampson
    Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520 8042, USA
    J Neurosci 26:13338-43. 2006
    ..In addition, these data raise the possibility that the individual differences in coupling strength between these two regions at rest predict differences in cognitive abilities important for this working memory task...
  82. ncbi Why the frontal cortex in autism might be talking only to itself: local over-connectivity but long-distance disconnection
    Eric Courchesne
    Department of Neurosciences, University of California, San Diego, CA, USA
    Curr Opin Neurobiol 15:225-30. 2005
    ....
  83. ncbi Human brain mechanisms of pain perception and regulation in health and disease
    A Vania Apkarian
    Department of Physiology, Northwestern University Medical School, 303 E Chicago Avenue, Ward 5 003, Chicago, IL 60611, USA
    Eur J Pain 9:463-84. 2005
    ..These neural mechanisms may then contribute to interindividual variations and disabilities associated with chronic pain conditions...
  84. ncbi Altered functional connectivity in early Alzheimer's disease: a resting-state fMRI study
    Kun Wang
    National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, People s Republic of China
    Hum Brain Mapp 28:967-78. 2007
    ..In addition, the results also suggest that AD may disturb the correlation/anti-correlation effect in the two intrinsically anti-correlated networks...
  85. pmc Suprachiasmatic nucleus: cell autonomy and network properties
    David K Welsh
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA
    Annu Rev Physiol 72:551-77. 2010
    ..Thus, even though individual SCN neurons can be cell-autonomous circadian oscillators, neuronal network properties are integral to normal function of the SCN...
  86. pmc The human connectome: A structural description of the human brain
    Olaf Sporns
    Department of Psychology, Indiana University, Bloomington, Indiana, United States of America
    PLoS Comput Biol 1:e42. 2005
    ..We propose a research strategy to achieve this goal, and discuss its potential impact...
  87. ncbi GABAergic hub neurons orchestrate synchrony in developing hippocampal networks
    P Bonifazi
    Institut de Neurobiologie de la Méditerranée INSERM U901, Universitéde la Méditerranée, Parc Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 9, France
    Science 326:1419-24. 2009
    ..These findings establish a central role for GABAergic interneurons in shaping developing networks and help provide a conceptual framework for studying neuronal synchrony...
  88. ncbi Cortical networks for working memory and executive functions sustain the conscious resting state in man
    B Mazoyer
    Groupe d'Imagerie Neurofonctionnelle, UMR6095, CNRS, LEA, , , Paris, France
    Brain Res Bull 54:287-98. 2001
    ....
  89. ncbi Role of delays in shaping spatiotemporal dynamics of neuronal activity in large networks
    Alex Roxin
    Laboratory of Neurophysics and Physiology, UMR8119 CNRS, Universite Rene Descartes, 45 Rue des Saints Peres, 75270 Paris Cedex 06, France
    Phys Rev Lett 94:238103. 2005
    ..The results derived in that framework allow us to understand the origin of the diversity of dynamical states observed in large networks of spiking neurons...
  90. ncbi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
    ..Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution...
  91. pmc The dynamic brain: from spiking neurons to neural masses and cortical fields
    Gustavo Deco
    Institucio Catalana de Recerca i Estudis Avancats ICREA, Universitat Pompeu Fabra, Department of Technology, Computational Neuroscience, Barcelona, Spain
    PLoS Comput Biol 4:e1000092. 2008
    ..We argue that elaborating principled and informed models is a prerequisite for grounding empirical neuroscience in a cogent theoretical framework, commensurate with the achievements in the physical sciences...
  92. ncbi Studying the human brain anatomical network via diffusion-weighted MRI and Graph Theory
    Yasser Iturria-Medina
    Neuroimaging Department, Cuban Neuroscience Center, Avenue 25, Esq 158, 15202, PO Box 6412, Cubanacan, Playa, Havana, Cuba
    Neuroimage 40:1064-76. 2008
    ..These results are in agreement with previous anatomical studies in the cat and macaque cerebral cortex...
  93. ncbi The neural bases of momentary lapses in attention
    D H Weissman
    Center for Cognitive Neuroscience and Department of Psychiatry, Duke University, Durham, North Carolina 27708, USA
    Nat Neurosci 9:971-8. 2006
    ..Our findings provide a new, system-wide understanding of the patterns of brain activity that are associated with brief attentional lapses, which informs both theoretical and clinical models of goal-directed behavior...
  94. pmc Dynamic causal models of steady-state responses
    R J Moran
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK
    Neuroimage 44:796-811. 2009
    ..We conclude with an illustrative application to multi-channel local field potential data acquired during a learning experiment in mice...
  95. pmc Ten simple rules for dynamic causal modeling
    K E Stephan
    Laboratory for Social and Neural Systems Research, Institute for Empirical Research in Economics, University of Zurich, Zurich, Switzerland
    Neuroimage 49:3099-109. 2010
    ..By providing good practice recommendations for DCM, in the form of ten simple rules, we hope that this article serves as a helpful tutorial for the growing community of DCM users...
  96. ncbi Parcellation-dependent small-world brain functional networks: a resting-state fMRI study
    Jinhui Wang
    State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China
    Hum Brain Mapp 30:1511-23. 2009
    ..This study provides quantitative evidence on how the topological organization of brain networks is affected by the different parcellation strategies applied...
  97. pmc Pyramidal cell communication within local networks in layer 2/3 of rat neocortex
    Carl Holmgren
    Karolinska Institute, Department of Neuroscience, Retzius vag 8, B2 2, S 17177 Stockholm, Sweden
    J Physiol 551:139-53. 2003
    ..With such a high degree of connectivity with surrounding pyramidal cells, local interneurons are ideally poised to both coordinate and expand the local pyramidal cell network via pyramidal-interneuron-pyramidal communication...
  98. ncbi Functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain
    Martijn P van den Heuvel
    Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Hum Brain Mapp 30:3127-41. 2009
    ..Our results suggest that the functionally linked resting-state networks reflect the underlying structural connectivity architecture of the human brain...
  99. ncbi The neural basis of temporal processing
    Michael D Mauk
    Department of Neurobiology and Anatomy, University of Texas, Houston Medical School, Houston, Texas 77030, USA
    Annu Rev Neurosci 27:307-40. 2004
    ..Rather temporal processing may rely on state-dependent changes in network dynamics...
  100. pmc Revealing modular architecture of human brain structural networks by using cortical thickness from MRI
    Zhang J Chen
    McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada H3A 2B4
    Cereb Cortex 18:2374-81. 2008
    ..This study provides the first report of modular architecture of the structural network in the human brain using cortical thickness measurements...
  101. ncbi Spike synchronization and rate modulation differentially involved in motor cortical function
    A Riehle
    Center for Research in Cognitive Neuroscience, CNRS, 31 Chemin Joseph Aiguier, 13402 Marseille Cx 20, France
    Science 278:1950-3. 1997
    ..These findings indicate that internally generated synchronization of individual spike discharges may subserve the cortical organization of cognitive motor processes...

Research Grants85

  1. Neuro-Robotic Models of Learning and Addiction
    Olaf Sporns; Fiscal Year: 2003
    ..A comprehensive and detailed embodied (robot) model has the potential of serving as a unique explanatory and predictive tool aiding in future empirical research on drug abuse and addiction. ..
  2. Network mechanisms for respiratory rhythm generation
    Nicholas Mellen; Fiscal Year: 2008
    ..We propose to test this hypothesis at the network level, by selectively modulating VIEB and VDEB networks, and at the single neuron level, by characterizing perturbation responses in synaptically isolated VIEBs and VDEBs. ..
  3. COGNITIVE LOSS WITH AGE--ROLE OF CORTICAL CATECHOLAMINES
    Amy Arnsten; Fiscal Year: 2007
    ..abstract_text> ..
  4. Estrogen, Stress and Dysfunction of Prefrontal Cortex
    Amy Arnsten; Fiscal Year: 2005
    ..This research will begin to reveal how estrogen amplifies the neurochemical cascades that lead to activation of CREB and dysfunction of the PFC during stress ..
  5. INFANT JOINT ATTENTION AND DEVELOPMENTAL OUTCOMES
    Peter Mundy; Fiscal Year: 2003
    ..abstract_text> ..
  6. Divalproex sodium and Risperidone in Pediatric Bipolar Disorder
    Mani Pavuluri; Fiscal Year: 2007
    ..During five years, 40 outpatient subjects with PBD manic or mixed episodes, ages 8-17 years, referred to the UI Pediatric Mood Disorder Clinic will be recruited. ..
  7. CHILDHOOD STIMULANT EXPOSURE IMPACT ON LATER DRUG ABUSE
    Francisco Castellanos; Fiscal Year: 2008
    ..abstract_text> ..
  8. Multivariate approaches to neuroimaging analysis
    Christian Habeck; Fiscal Year: 2009
    ..Finally, we will provide a software analysis package that will integrate the most common features of multivariate approaches in a user-friendly manner. ..
  9. High Resolution EEG Source Imaging: Validation Study
    Bin He; Fiscal Year: 2005
    ..The studies addressed in this application may establish CIT as a clinically useful tool aiding neurosurgical planning in epilepsy patients. ..
  10. Acoustic Interference on Attention in HIV Patients
    Dardo Tomasi; Fiscal Year: 2003
    ..More generally, this study will also improve the understanding of the neural effects of acoustic noise interference during fMRI studies in healthy populations. ..
  11. Neural Substrates of Variability in Attention Deficit Hyperactivity Disorder (ADH
    Francisco Xavier Castellanos; Fiscal Year: 2010
    ..Achieving such a level of detailed information about brain functioning in ADHD would have major impact on our ability to improve methods of diagnosing ADHD and of developing new treatments. ..
  12. Dyspraxia and Autonomic Control in Very Early AD
    Donald Royall; Fiscal Year: 2004
    ..Some dementia treatments are known to reduce HRV, and possibly mortality as well. Alternatively, some psychotropics may increase arrhythmia-related mortality, possibly via a central mechanism. ..
  13. A Computational Approach for 3D Brain Source Imaging
    Bin He; Fiscal Year: 2010
    ..The availability of a noninvasive imaging technology to identify and image the epileptogenic foci would benefit numerous patients suffering from epilepsy and the healthcare system. ..
  14. Three Dimensional Electrocardiographic Imaging
    Bin He; Fiscal Year: 2010
    ....
  15. Wavelets, fractals and fMRI of brain adaptivity
    Edward Bullmore; Fiscal Year: 2007
    ..We will also test hypotheses concerning the main effect of aging and the interactive effect of drugs and age on brain adaptivity. ..
  16. VAS-COG 2007
    Donald Royall; Fiscal Year: 2007
    ..Many vascular cognitive disorders are preventable and potentially reversible. VAS-COG will provide a forum in which information on these important conditions can be exchanged and disseminated. [unreadable] [unreadable] [unreadable]..
  17. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2008
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
  18. Magnetoacoustic Tomography with Magnetic Induction
    Bin He; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  19. Request for Leica SP2MP Confocal/Multiphoton Microscope
    Gina Turrigiano; Fiscal Year: 2003
    ..In addition to the user group, the confocal/multiphoton facility will be available to all life science researchers at Brandeis who have a need for this technology on a time-available basis. ..
  20. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  21. Neural Circuits and Plasticity Gordon Conference
    Gina Turrigiano; Fiscal Year: 2005
    ..We are requesting support to fund the attendance of underrepresented groups in the field of Neural Circuit plasticity, including women and ethnic minorities. ..
  22. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  23. LONGITUDINAL FMRI STUDY OF COGNITIVE DEVELOPMENT
    Vinod Menon; Fiscal Year: 2005
    ..The proposed fMRI research project will yield important new and more precise information about the neural bases of the development of higher cognitive processes in children as well as its disruption in atypical development. ..
  24. Insular AD Pathology and Autonomic Function
    Donald Royall; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  25. Pilot Study of an Internet-based Cognitive Stimulation Program in AIDS
    James Becker; Fiscal Year: 2008
    ..If this is true, then it means that people with mild forms of cognitive impairment may be able to help themselves to get better. [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Artifact reduction in simultaneous EEG and fMRI recordings
    Vinod Menon; Fiscal Year: 2008
    ..Findings from our study will also propel the development of new approaches to investigate the neural bases of psychiatric, neurological and neurodevelopmental disorders. [unreadable] [unreadable] [unreadable]..
  27. Modulation of auditory processing by behavioral state
    Marc Schmidt; Fiscal Year: 2009
    ..We hypothesize that the behavioral context with which the heard song is produced as well as the identity of the singer will significantly influence auditory responses. ..
  28. Neural Dissection of Hyperactivity/Inattention in Autism
    Francisco Xavier Castellanos; Fiscal Year: 2010
    ..If successful, we will be able to better understand the types of brain mechanisms that are involved in hyperactivity and inattention in children with autism and then be able to use that information to guide targeted treatment studies. ..
  29. Mapping Basal Ganglia Function During Motor Sequencing
    Vinod Menon; Fiscal Year: 2002
    ..Furthermore, the proposed research will aid in understanding and treating basal ganglia disorders, such as schizophrenia, ADHD, Huntington's disease, Parkinson's disease, and Tourette's syndrome. ..
  30. HIV1 RELATED NEUROPSYCHOLOGICAL ABNORMALITIES
    James Becker; Fiscal Year: 2002
    ..By studying MCMD in detail, and the factors that predict transition to MCMD and HAD, it may be possible to provide information useful to the development of rational treatment strategies directed at cognitive dysfunction. ..
  31. Early Randomized Surgical Epilepsy Trial
    Jerome Engel; Fiscal Year: 2007
    ..abstract_text> ..
  32. Cognitive Neuroscience of Mathematical Development
    Vinod Menon; Fiscal Year: 2010
    ..This work has the potential to have broad impact on developmental cognitive neuroscience, brain development, and clinical psychology. ..
  33. Homeostatic tuning of synapses in recurrent networks
    Gina Turrigiano; Fiscal Year: 2006
    ....
  34. SENSORY AND MOTOR INTEGRATION IN THE SPINAL CORD
    PAUL S STEIN; Fiscal Year: 2010
    ..There is considerable similarity in the organization of spinal cord in all vertebrates, including humans. Our findings of CPG organization will be of interest to those developing new therapies for spinal-injured humans. ..
  35. Age Moderates HIV-Related CNS Dysfunction
    James Becker; Fiscal Year: 2005
    ..By carefully characterizing the neuropsychological deficits (including those identified using brain imaging technology) we will be better able to understand the interactive effects of agingand HIVIAIDS. ..
  36. NEUROTRANSMITTER MODULATION OF NEURONAL CIRCUITS
    Eve Marder; Fiscal Year: 2009
    ..abstract_text> ..
  37. MECHANISMS OF LONG-TERM POTENTIATION
    John E Lisman; Fiscal Year: 2010
    ..Positive results would strongly argue that the CaMKII-NMDA complex is critical for the storage of synaptic memory and would set the stage for studying the role of this complex in the maintenance of behavioral memory. ..
  38. An in vivo cellular model to study the biological effects of alcohol
    Su Guo; Fiscal Year: 2010
    ..Further, molecules identified in zebrafish will provide candidate genes for association study of human alcoholism and alcoholic medical disorders. ..
  39. The Roles of Spinobulbar Neurons in Locomotor Activity
    James Buchanan; Fiscal Year: 2007
    ..abstract_text> ..
  40. Sleep Regulation - The Involvement of GHRH
    James Krueger; Fiscal Year: 2009
    ..Anticipated results are expected to support the hypothesis that GHRH is a key regulatory component of NREMS and provide cellular mechanistic explanations for the involvement of GHRH in sleep regulation. ..
  41. PERCEPTUAL CLASSIFICATION, LEARNING, AND MEMORY
    ROBERT NOSOFSKY; Fiscal Year: 2007
    ..abstract_text> ..
  42. Non-invasive Fast Optical Imaging of Visual and Motor Processing
    Andrei Medvedev; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Depression Prevention Program for High-Risk Adolescents
    Eric Stice; Fiscal Year: 2008
    ..Thus, the proposed project should provide a rigorous evaluation of this promising brief prevention program and should advance knowledge regarding the prevention of this pernicious psychiatric problem. [unreadable] [unreadable]..
  44. Neural Mechanisms of MTBI: A Prospective fMRI Approach
    J A Scott Kelso; Fiscal Year: 2008
    ..This individualized approach should provide important insights into the structural and dynamic mechanisms underlying recovery of function in the human brain. ..
  45. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2007
    ..abstract_text> ..
  46. PHYSIOLOGY OF STATUS EPILEPTICUS IN VITRO
    DOUGLAS COULTER; Fiscal Year: 2008
    ..abstract_text> ..
  47. SYNAPTIC VESICLE TRAFFICKING IN HIPPOCAMPAL SYNAPSES
    Venkatesh N Murthy; Fiscal Year: 2010
    ..These experiments will elucidate fundamental presynaptic mechanisms of vesicle traffic in GABAergic synapses and how they are altered by activity. ..
  48. Electrical Stimulation of Cortical Motor Output
    Paul Cheney; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  49. MULTI-PHOTON CONFOCAL MICROSCOPE SYSTEM
    Maiken Nedergaard; Fiscal Year: 2001
    ..The multi-photon confocal microscope system will become a core facility at New York Medical College, serving the entire medical science community. ..
  50. PREVENTION OF SUICIDE IN THE ELDERLY
    George Alexopoulos; Fiscal Year: 2002
    ..Data will also be collected to document the impact of intervention on patient care, and on physician knowledge, attitudes, and satisfaction and test hypotheses derived from preliminary studies of the three IRCs. ..
  51. IMAGING AND MODELING THERAPEUTIC MECHANISMS OF ACTION
    Peter Fox; Fiscal Year: 2003
    ....
  52. DYNAMIC PATTERNS IN COMPLEX BIOLOGICAL SYSTEMS
    J A Scott Kelso; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  53. GABAergic Circuits Critical period in Visual Cortex
    Z Huang; Fiscal Year: 2005
    ..abstract_text> ..
  54. NEUROBIOLOGICAL BASIS OF DEPRESSION AFTER BRAIN DAMAGE
    Ana Solodkin; Fiscal Year: 2003
    ..At the same time, the current research aims to give the principal investigator necessary mentored experience to achieve independence in biological psychiatry research. ..
  55. LANGUAGE AND MOTOR PLASTICITY: FMRI IN CHILDREN
    RALPH AXEL MUELLER; Fiscal Year: 2004
    ..Findings are expected to contribute to the understanding of compensatory plasticity in development. ..
  56. PROCESSING OF VISUAL SCENES BY THE LGN
    R Reid; Fiscal Year: 2004
    ..Only by exploring the normal activity of multiple thalamic inputs to cortical neurons can we begin to understand functional disorders of this pathway, such as in certain forms of epilepsy. ..
  57. METANALYSIS COGNITIVE NEUROIMAGING: METHODS VALIDATIONS
    Peter Fox; Fiscal Year: 2002
    ..As this approach to metanalysis is new and substantially different from prior forms of metanalysis, the field of informatics stands to benefit from the validation of a new analysis paradigm. ..
  58. Dynamic Measures of Neurochemistry in Mood Disorders
    Ronald Salomon; Fiscal Year: 2006
    ..abstract_text> ..
  59. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  60. CELLULAR SIGNAL PROCESSING IN FLY MOTION VISION
    Alexander Borst; Fiscal Year: 2001
    ..The experimental data undergo an information theoretic analysis and compared to the performance of biophysically realistic computer models of the cells. ..
  61. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001
    ....
  62. MYOGLOBIN DETECTION AND OXIDATIVE METABOLISM
    Kamil Ugurbil; Fiscal Year: 2002
    ....
  63. NEURO-AIDS IN OPIATE DEPENDENT RHESUS MACAQUES
    Paul Cheney; Fiscal Year: 2005
    ..A fifth specific aim will investigate the cellular and molecular mechanisms by which morphine influences viral replication and co-receptor expression in lymphocyte and macrophage populations. ..
  64. Divergence and Variability of Language Maps in Autism
    RALPH AXEL MUELLER; Fiscal Year: 2006
    ..Identifying such links between brain maps and level of functioning achieved in adults will elucidate the significance of individual variation in autism in terms of different pathways of etiology and abnormal development. ..
  65. A Spiking Model of Hippocampus for Guiding Behavior
    Michael Hasselmo; Fiscal Year: 2006
    ..U., which focuses on modeling operant tasks used in experimental studies of drug self-administration phenomena, in work supported by a supplement to a previous grant from NIDA. [unreadable] [unreadable]..
  66. Differential regulation of kisspeptin, dynorphin, and NKB in the same neurons
    Robert Goodman; Fiscal Year: 2007
    ..Thus, these studies may provide information important for the development of better treatments of these pathological disruptions of reproductive function. [unreadable] [unreadable] [unreadable]..
  67. Vascular Depression: Longitudinal Followup
    Yvette I Sheline; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  68. ACTIVATION OF TONGUE MUSCLES IN OBSTRUCTIVE SLEEP APNEA
    Dominique Durand; Fiscal Year: 2004
    ..It is anticipated that the experimental delineation and validation of these methods will lead to a design of a neuroprosthetic device for the treatment of OSA. ..
  69. INTEGRATIVE APPROACH TO CORTICAL COGNITIVE NETWORKS
    JOAQUIN FUSTER; Fiscal Year: 2009
    ..These correlations are expected to provide crucial information on the neuronal basis of functional imaging signals, such as those obtained by BOLD fMRI, in human cognition. ..
  70. COMPUTATIONAL ASPECTS OF PRIMATE MEMORY
    JOAQUIN FUSTER; Fiscal Year: 2004
    ..A better understanding of the neural dynamics of memory may help us better understand the pathogenesis of memory disorders in the mentally ill and thus lead to better treatments. ..
  71. VISUAL COGNITION
    Nancy Kanwisher; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  72. SENSITIZATION AND CONDITIONING WITH ETHANOL
    KENT BERRIDGE; Fiscal Year: 2006
    ..abstract_text> ..
  73. Neuromodulation and Neuronal Dynamics
    John White; Fiscal Year: 2008
    ..Because this work will further our understanding of how high-rate neuronal activity is amplified further by the synapse, it may provide insights into diseases involving runaway excitation (e.g. temporal lobe epilepsy). ..
  74. Function of Casein Kinase 2 in the Circadian Clock
    Ravi Allada; Fiscal Year: 2007
    ..The discovery of a circadian function of CK2 in plants, animals, and fungi suggests these studies will be relevant to many biological systems, including humans. ..
  75. LOCAL INTERACTIONS BETWEEN HIPPOCAMPAL NEURONS
    F Edward Dudek; Fiscal Year: 2006
    ....
  76. Network Models of Seizure Dynamics and Evolution
    Pawel Kudela; Fiscal Year: 2008
    ..This can facilitate development of technology for controlling or reducing the frequency of seizures and lead to possibilities for developing new treatment options for patients with epilepsy. [unreadable] [unreadable] [unreadable]..
  77. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 2003
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  78. PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRI
    Wei Chen; Fiscal Year: 2005
    ....
  79. Network requirements for parametric working memory
    Paul Miller; Fiscal Year: 2006
    ..He will test which forms of short-term plasticity lead to the observed behavior, and whether they contribute to the stability of the mnemonic states. ..
  80. Structural-functional MRI Studies of Memory in MCI & AD
    Bradford Dickerson; Fiscal Year: 2007
    ..abstract_text> ..
  81. Combined OEG transplantation and step training promote regeneration in adult SCI
    V Edgerton; Fiscal Year: 2009
    ..Our long term goal is to regain voluntary control of hindlimb stepping after a complete midthoracic spinal cord injury in an adult animal. ..
  82. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 2003
    ..abstract_text> ..
  83. Neural Coding Primate Vocalizations in Auditory Cortex
    Christopher DiMattina; Fiscal Year: 2004
    ..abstract_text> ..