spinal ganglia

Summary

Summary: Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.

Top Publications

  1. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
  2. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
  3. pmc Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    BMC Neurosci 3:16. 2002
  4. pmc TRPA1 mediates formalin-induced pain
    Colleen R McNamara
    Hydra Biosciences, Inc, 790 Memorial Drive, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:13525-30. 2007
  5. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
  6. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
  7. pmc Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
    Hua Sheng Xiao
    Laboratory of Sensory System, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 99:8360-5. 2002
  8. ncbi Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    Mark J Zylka
    Division of Biology, 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 45:17-25. 2005
  9. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
  10. ncbi P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 420:74-8. 2002

Detail Information

Publications358 found, 100 shown here

  1. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
    ..Accordingly, blockade of the CCR2 receptor may provide a novel therapeutic modality for the treatment of chronic pain...
  2. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
    ..Coactivation of p38 in DRG neurons and spinal microglia may contribute to later phases of neuropathic pain...
  3. pmc Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury
    Michael Costigan
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    BMC Neurosci 3:16. 2002
    ..Two comparisons were made using two sets of triplicate microarrays, naïve versus naïve and naïve versus axotomy...
  4. pmc TRPA1 mediates formalin-induced pain
    Colleen R McNamara
    Hydra Biosciences, Inc, 790 Memorial Drive, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:13525-30. 2007
    ....
  5. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  6. ncbi Distinct expression of TRPM8, TRPA1, and TRPV1 mRNAs in rat primary afferent neurons with adelta/c-fibers and colocalization with trk receptors
    Kimiko Kobayashi
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo 663 8501, Japan
    J Comp Neurol 493:596-606. 2005
    ....
  7. pmc Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain
    Hua Sheng Xiao
    Laboratory of Sensory System, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, China
    Proc Natl Acad Sci U S A 99:8360-5. 2002
    ..Our findings therefore reveal dynamic and complex changes in molecular diversity among DRG neurons after axotomy. Sequences reported in this paper have been deposited in the GenBank database (accession numbers BG 662484-BG 673712)..
  8. ncbi Topographically distinct epidermal nociceptive circuits revealed by axonal tracers targeted to Mrgprd
    Mark J Zylka
    Division of Biology, 216 76, California Institute of Technology, Pasadena, CA 91125, USA
    Neuron 45:17-25. 2005
    ..Thus, afferent input from different layers of the epidermis is conveyed by topographically segregated sensory circuits, suggesting that at least some aspects of sensory information processing may be organized along labeled lines...
  9. ncbi p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia
    Ru Rong Ji
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Neuron 36:57-68. 2002
    ....
  10. ncbi P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp
    Kevin C Wang
    Division of Neuroscience, Children s Hospital and Program in Neuroscience, Harvard Medical School, 320 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 420:74-8. 2002
    ..Thus, interfering with p75 and its downstream signalling pathways may allow lesioned axons to overcome most of the inhibitory activities associated with central nervous system myelin...
  11. pmc Excitatory monocyte chemoattractant protein-1 signaling is up-regulated in sensory neurons after chronic compression of the dorsal root ganglion
    Fletcher A White
    Department of Cell Biology, Neurobiology, and Anatomy, and Anesthesiology, Stritch School of Medicine, Loyola University Chicago, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 102:14092-7. 2005
    ..MCP-1/CCR2 signaling is directly involved with a chronic compression injury and may contribute to associated neuronal hyperexcitability and neuropathic pain...
  12. ncbi Axonal neuregulin-1 regulates myelin sheath thickness
    Galin V Michailov
    Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    Science 304:700-3. 2004
    ..We suggest a model by which myelin-forming Schwann cells integrate axonal Nrg1 signals as a biochemical measure of axon size...
  13. ncbi Beyond neurons: evidence that immune and glial cells contribute to pathological pain states
    Linda R Watkins
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Boulder, Colorado
    Physiol Rev 82:981-1011. 2002
    ..Indeed, all nerves and neurons regardless of modality or function are likely affected by immune and glial activation in the ways described for pain...
  14. pmc Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo
    X Fang
    Department of Physiology, University of Bristol, Medical School, University Walk, Bristol BS8 1TD, UK
    J Physiol 565:927-43. 2005
    ..These findings indicate both the usefulness and limitations of using electrophysiological criteria for identifying neurones acutely in vitro as nociceptive...
  15. pmc The TTX-resistant sodium channel Nav1.8 (SNS/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons
    Laiche Djouhri
    Department of Physiology, University of Bristol Medical School, Bristol BS8 1TD, UK
    J Physiol 550:739-52. 2003
    ..Thus high levels of Nav1.8 protein may contribute to the longer AP durations (especially in A-fibre neurons) and larger AP overshoots that are typical of nociceptors...
  16. ncbi The mammalian sodium channel BNC1 is required for normal touch sensation
    M P Price
    Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA
    Nature 407:1007-11. 2000
    ..These data identify the BNC1 channel as essential for the normal detection of light touch and indicate that BNC1 may be a central component of a mechanosensory complex...
  17. pmc Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide
    V Vellani
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QJ, UK
    J Physiol 534:813-25. 2001
    ..The results are consistent with a model in which phosphorylation of VR1 by PKC increases the probability of channel gating by agonists, and in which dephosphorylation occurs by a calcium-dependent process...
  18. ncbi Spinal axon regeneration induced by elevation of cyclic AMP
    Jin Qiu
    Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Neuron 34:895-903. 2002
    ..Importantly, DRG injection of db-cAMP results in extensive regeneration of dorsal column axons lesioned 1 week later. These results may be relevant to developing therapies for spinal cord injury...
  19. ncbi Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin
    Aziz Moqrich
    Department of Cell Biology, Scripps Research Institute, La Jolla, CA 92037, USA
    Science 307:1468-72. 2005
    ..Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation...
  20. pmc Comparison of dorsal root ganglion gene expression in rat models of traumatic and HIV-associated neuropathic pain
    Klio Maratou
    Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London, UK
    Eur J Pain 13:387-98. 2009
    ..As an external control, the RNA expression of three genes was examined by RT-PCR, while the protein levels of two were studied using western blot analysis...
  21. ncbi IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life
    D C Molliver
    Department of Neurology, Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 19:849-61. 1997
    ..Together, our findings suggest that IB4-binding neurons switch from dependence on NGF in embryonic life to dependence on GDNF in postnatal life and are likely regulated by GDNF in maturity...
  22. pmc TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury
    Koichi Obata
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo, Japan
    J Clin Invest 115:2393-401. 2005
    ..Thus, blocking TRPA1 in sensory neurons might provide a fruitful strategy for treating cold hyperalgesia caused by inflammation and nerve damage...
  23. ncbi The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons
    Xin Fang
    Department of Physiology, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom
    J Neurosci 22:7425-33. 2002
    ..The data provide direct evidence that Na(v)1.9 is expressed selectively in (but not in all) C- and A-fiber nociceptive-type units and suggest that Na(v)1.9 contributes to membrane properties that are typical of nociceptive neurons...
  24. ncbi Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain
    Joel A Black
    Department of Neurology and Paralyzes Veterans of America, Eastern Paralyzed Veterans Association Neuroscience Research Center, Yale University School of Medicine, New Haven CT 06510, USA
    Pain 108:237-47. 2004
    ....
  25. ncbi Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons
    Chao Ma
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurophysiol 89:1588-602. 2003
    ....
  26. ncbi The transcription factor ATF-3 promotes neurite outgrowth
    Rhona Seijffers
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Mol Cell Neurosci 32:143-54. 2006
    ..Furthermore, ATF-3 promotes long sparsely branched neurites. ATF-3 overexpression did not increase c-Jun expression. ATF-3 may contribute, therefore, to neurite outgrowth by orchestrating the gene expression responses in injured neurons...
  27. pmc Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
    S G Waxman
    Department of Neurology, Yale University School of Medicine, New Haven 06510
    J Neurophysiol 72:466-70. 1994
    ..Different channel characteristics, as well as an altered spatial distribution of sodium channels, may contribute to the electrophysiological changes that are observed in axotomized neurons...
  28. pmc TREK-1 is a heat-activated background K(+) channel
    F Maingret
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    EMBO J 19:2483-91. 2000
    ..Expression of TREK-1 in peripheral sensory neurons as well as in central hypothalamic neurons makes this K(+) channel an ideal candidate as a physiological thermoreceptor...
  29. ncbi Enhanced excitability of dissociated primary sensory neurons after chronic compression of the dorsal root ganglion in the rat
    Chao Ma
    Department of Anesthesiology, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06510, USA
    Pain 113:106-12. 2005
    ..For small-sized neurons, the effects of CCD observed in the intact DRG are less apparent after dissociation possibly due to the hyperexcitability produced by the dissociation process itself...
  30. ncbi Development of sensory neurons in the absence of NGF/TrkA signaling in vivo
    T D Patel
    University of North Carolina Neuroscience Center, University of North Carolina, Chapel Hill 27599, USA
    Neuron 25:345-57. 2000
    ..These findings establish that NGF/TrkA signaling regulates peripheral target field innervation and is required for the full phenotypic differentiation of sensory neurons...
  31. ncbi CCL2 and CXCL1 trigger calcitonin gene-related peptide release by exciting primary nociceptive neurons
    Xiaomei Qin
    Institute of Vascular Medicine, Peking University Third Hospital, Beijing, People s Republic of China
    J Neurosci Res 82:51-62. 2005
    ....
  32. ncbi Visualizing cold spots: TRPM8-expressing sensory neurons and their projections
    Ajay Dhaka
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 28:566-75. 2008
    ..We show that TRPM8 expression functionally associates with cold sensitivity in cultured DRGs, and provide the first glimpses of the unique anatomical architecture of cold fibers in vivo...
  33. ncbi Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons
    Nathaniel T Blair
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 20114, USA
    J Neurosci 22:10277-90. 2002
    ....
  34. pmc Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons
    J J Toledo-Aral
    Department of Neurobiology and Behavior, State University of New York at Stony Brook, 11794 5230, USA
    Proc Natl Acad Sci U S A 94:1527-32. 1997
    ..The preferential localization suggests that the PN1 sodium channel plays a specific role in nerve excitability...
  35. ncbi Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation
    Maria Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, La Jolla, California 92093 0818, USA
    J Neurosci 23:3028-38. 2003
    ..We conclude that injured and adjacent uninjured DRG neurons are sensitized to TNF after SNL. Sensitization to endogenous TNF may be essential for the development and maintenance of neuropathic pain...
  36. ncbi Widespread elimination of naturally occurring neuronal death in Bax-deficient mice
    F A White
    Department of Neurology, Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 18:1428-39. 1998
    ..However, rescue from naturally occurring cell death does not imply that the neurons will develop normal functional capabilities...
  37. ncbi Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation
    Chongyang Han
    Department of Neurology, LCI 707, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Brain 132:1711-22. 2009
    ....
  38. ncbi Small proline-rich repeat protein 1A is expressed by axotomized neurons and promotes axonal outgrowth
    Iris E Bonilla
    Department of Neurology and Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:1303-15. 2002
    ..In axotomized sensory neurons, reduction of SPRR1A function restricts axonal outgrowth. Neuronal SPRR1A may be a significant contributor to successful nerve regeneration...
  39. ncbi Different signaling pathways mediate regenerative versus developmental sensory axon growth
    R Y Liu
    Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Neurosci 21:RC164. 2001
    ....
  40. ncbi Inhibition of neuropathic pain by decreased expression of the tetrodotoxin-resistant sodium channel, NaV1.8
    Josephine Lai
    Department of Pharmacology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Pain 95:143-52. 2002
    ..These data provide direct evidence linking NaV1.8 to neuropathic pain. As NaV1.8 expression is restricted to sensory neurons, this channel offers a highly specific and effective molecular target for the treatment of neuropathic pain...
  41. ncbi The differential expression patterns of messenger RNAs encoding K-Cl cotransporters (KCC1,2) and Na-K-2Cl cotransporter (NKCC1) in the rat nervous system
    C Kanaka
    Department of Anatomy and Neuroscience, Hamamatsu University School of Medicine, 3600 Handa, Hamamatsu, Shizuoka 431-3192, Japan
    Neuroscience 104:933-46. 2001
    ..These results clearly indicate a wide area- and cell-specific variation of cation chloride cotransporters, emphasizing the central role of anionic homeostasis in neuronal function and communication...
  42. pmc Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons
    Hosung Jung
    Department of Molecular Pharmacology and Biological Chemistry and Interdepartmental Neuroscience Program, Northwestern University, Chicago, Illinois 60611, USA
    J Neurochem 104:254-63. 2008
    ..Our results suggest that MCP-1 and CCR2, up-regulated by sensory neurons following peripheral nerve injury, might participate in neural signal processing which contributes to sustained excitability of primary afferent neurons...
  43. ncbi Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity
    C Tohda
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    J Neurochem 76:1628-35. 2001
    ..Thus, peripheral inflammation induces the axonal transport of VR1 mRNA, which may be involved in the hypersensitivity of primary afferents to capsaicin and the production of inflammatory hyperalgesia...
  44. ncbi Acetylcholine synthesis by choline acetyltransferase of a peripheral type as demonstrated in adult rat dorsal root ganglion
    Jean Pierre Bellier
    Molecular Neuroscience Research Center, Shiga University of Medical Science, Otsu, Shiga, Japan
    J Neurochem 101:1607-18. 2007
    ..Thus pChAT provides a new window on the role of neuronal acetylcholine...
  45. ncbi Localization of the endocannabinoid-degrading enzyme fatty acid amide hydrolase in rat dorsal root ganglion cells and its regulation after peripheral nerve injury
    Isobel J Lever
    Pain Research Group, Department of Anaesthetics, Pain Medicine and Intensive Care, Faculty of Medicine, Imperial College London, Chelsea and Westminster Hospital Campus, London SW10 9NH, UK
    J Neurosci 29:3766-80. 2009
    ..This study reveals the location of FAAH in neural tissue involved in peripheral nociceptive transmission...
  46. ncbi Dorsal root potentials and dorsal root reflexes: a double-edged sword
    W D Willis
    Department of Anatomy and Neurosciences and Marine Biomedical Institute, University of Texas Medical Branch, Galveston 77555 1069, USA
    Exp Brain Res 124:395-421. 1999
    ..The conversion of an inhibitory process, presynaptic inhibition, to an excitatory one by DRRs can thus lead to pathological consequences...
  47. ncbi Proinflammatory chemokines, such as C-C chemokine ligand 3, desensitize mu-opioid receptors on dorsal root ganglia neurons
    Ning Zhang
    Laboratory of Molecular Immunoregulation, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 173:594-9. 2004
    ..Our data indicate that proinflammatory chemokines are capable of desensitizing mu-opioid receptors on peripheral sensory neurons, providing a novel potential mechanism for peripheral inflammation-induced hyperalgesia...
  48. ncbi Morphological and physiological features of a set of spinal substantia gelatinosa neurons defined by green fluorescent protein expression
    Adam W Hantman
    Department of Cell and Molecular Physiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 24:836-42. 2004
    ....
  49. ncbi p75 neurotrophin receptor mediates neuronal cell death by activating GIRK channels through phosphatidylinositol 4,5-bisphosphate
    Elizabeth J Coulson
    Queensland Brain Institute and School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    J Neurosci 28:315-24. 2008
    ..Our results demonstrate a novel mode of activation of GIRK channels, representing an early step in the p75(NTR)-mediated cell death pathway and suggesting a function for these channels during nervous system development...
  50. ncbi Evidence that Wallerian degeneration and localized axon degeneration induced by local neurotrophin deprivation do not involve caspases
    J T Finn
    Medical Research Council Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 20:1333-41. 2000
    ..Our results suggest that a neuron contains at least two molecularly distinct self-destruction programs, one for caspase-dependent apoptosis and another for selective axon degeneration...
  51. ncbi Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
    J B Davis
    Department of Neuroscience Research, SmithKline Beecham Pharmaceuticals, Harlow, UK
    Nature 405:183-7. 2000
    ..We conclude that VR1 is required for inflammatory sensitization to noxious thermal stimuli but also that alternative mechanisms are sufficient for normal sensation of noxious heat...
  52. ncbi Change in mRNAs for neuropeptides and the GABA(A) receptor in dorsal root ganglion neurons in a rat experimental neuropathic pain model
    T Fukuoka
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Nishinomiya, Japan
    Pain 78:13-26. 1998
    ....
  53. ncbi Extreme stretch growth of integrated axons
    Bryan J Pfister
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:7978-83. 2004
    ..These data provide the first evidence that mechanical stimuli can induce extreme "stretch growth" of integrated axon tracts, far exceeding any previously observed limits of axon growth...
  54. ncbi Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors
    T Takahashi
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cell 99:59-69. 1999
    ..Sema3A treatment leads to the redistribution of growth cone NP-1 and plexin into clusters. Thus, physiologic Sema3A receptors consist of NP-1/plexin complexes...
  55. ncbi Increased nerve growth factor after rat plantar incision contributes to guarding behavior and heat hyperalgesia
    Ratan K Banik
    Department of Anesthesia, 3000 ML, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA
    Pain 117:68-76. 2005
    ..NGF contributes to some incision-induced pain behaviors, guarding and heat hyperalgesia. Anti-NGF did not affect the extent of sensitization of C-fibers observed in vitro...
  56. ncbi Intravenous paclitaxel administration in the rat induces a peripheral sensory neuropathy characterized by macrophage infiltration and injury to sensory neurons and their supporting cells
    Christopher M Peters
    Departments of Diagnostic and Biological Sciences, Neuroscience, Psychiatry, Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA
    Exp Neurol 203:42-54. 2007
    ..An understanding of the factors involved in the development and maintenance of PN may lead to mechanism based therapies that prevent/treat PN and thus improve the survival and quality of life of patients receiving chemotherapy...
  57. pmc A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
    Michael F Jarvis
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 104:8520-5. 2007
    ..These data demonstrate that acute and selective pharmacological blockade of Na(v)1.8 sodium channels in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain...
  58. ncbi A common mechanism of action for three mood-stabilizing drugs
    Robin S B Williams
    Intracellular Signalling Group, MRC Laboratory for Molecular Cell Biology, University College London, Gower St, London WC1E 6BT, UK
    Nature 417:292-5. 2002
    ..Inhibitors of prolyl oligopeptidase reverse the effects of all three drugs on sensory neuron growth cone area and collapse. These results suggest a molecular basis for both bipolar affective disorder and its treatment...
  59. pmc Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons
    Anthony M Rush
    NeuroSolutions Ltd, PO Box 3517, Coventry CV4 7ZS, UK
    J Physiol 579:1-14. 2007
    ....
  60. pmc Altered functional properties of satellite glial cells in compressed spinal ganglia
    Haijun Zhang
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Glia 57:1588-99. 2009
    ..However, these alterations are not fully sustained and suggest other mechanisms for the maintenance of the hyperexcitable state...
  61. ncbi An essential cytoskeletal linker protein connecting actin microfilaments to intermediate filaments
    Y Yang
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, Illinois 60637, USA
    Cell 86:655-65. 1996
    ..In BPAG1 null mice, axonal architecture is markedly perturbed, consistent with a failure to tether neurofilaments to the actin cytoskeleton and underscoring the physiological relevance of this protein...
  62. pmc Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors
    Daniel Vilceanu
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226 0509, USA
    J Pain 11:588-99. 2010
    ..Also, SNL had no effect on heat responses in medium-large-diameter neurons from either the injured or adjacent ganglia...
  63. ncbi Regeneration of sensory axons within the injured spinal cord induced by intraganglionic cAMP elevation
    Simona Neumann
    Department of Anatomy and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, CA 94143, USA
    Neuron 34:885-93. 2002
    ..Thus, stimulating cAMP signaling increases the intrinsic growth capacity of injured sensory axons. This approach may be useful in promoting regeneration after spinal cord injury...
  64. pmc A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons
    Anthony M Rush
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 103:8245-50. 2006
    ..Moreover, these findings show that a single ion channel mutation can produce opposing phenotypes (hyperexcitability or hypoexcitability) in the different cell types in which the channel is expressed...
  65. ncbi Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha
    Xiaochun Jin
    Washington University Pain Center, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:246-55. 2006
    ..These results suggest that TNFalpha may induce acute peripheral mechanical sensitization by acting directly on TNFR1 in primary afferent neurons, resulting in p38-dependent modulation of TTX-resistant Na+ channels...
  66. ncbi Activated CREB is sufficient to overcome inhibitors in myelin and promote spinal axon regeneration in vivo
    Ying Gao
    Biology Department, Hunter College, City University of New York, 695 Park Avenue, New York, NY 10021, USA
    Neuron 44:609-21. 2004
    ..These results indicate that CREB plays a central role in overcoming myelin inhibitors and so encourages regeneration in vivo...
  67. ncbi Identification of candidate transcriptional modulators involved in successful regeneration after nerve injury
    Floor J Stam
    Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, Vrije Universiteit, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands
    Eur J Neurosci 25:3629-37. 2007
    ..This gene, and others identified in this study, may be part of the transcriptional regulatory module that orchestrates the onset of successful regeneration...
  68. ncbi 2-aminoethoxydiphenyl borate is a common activator of TRPV1, TRPV2, and TRPV3
    Hong Zhen Hu
    Department of Physiology and Cell Biology, The Ohio State University, Columbus Ohio 43210, USA
    J Biol Chem 279:35741-8. 2004
    ..Our data suggest the existence of a common activation mechanism for TRPV1, TRPV2, and TRPV3 that may serve as a therapeutic target for pain management and treatment for diseases caused by hypersensitivity and temperature misregulation...
  69. pmc Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat
    Satoru Matayoshi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Physiol 569:685-95. 2005
    ..BDNF may thereafter induce monosynaptic Abeta afferents to the SG, thereby developing hyperalgesia and/or allodynia during inflammation...
  70. pmc Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Nav 1.7 (PN1) Na+ channel alpha subunit protein
    Laiche Djouhri
    Department of Physiology, School of Medical Sciences, University Walk, Bristol BS8 1TD, UK
    J Physiol 546:565-76. 2003
    ..Since nociceptive units tend overall to have longer duration APs, slower CVs and smaller somata, these correlations may be related to the generally greater expression of Na(v)1.7 in nociceptive units...
  71. ncbi Differential role of N-type calcium channel splice isoforms in pain
    Christophe Altier
    Hotchkiss Brain Institute, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 1N4
    J Neurosci 27:6363-73. 2007
    ..In contrast, both N-type channel isoforms (e37a- and e37b-containing) contribute to tactile neuropathic allodynia. Hence, exon 37a acts as a molecular switch that tailors the channels toward specific roles in pain...
  72. ncbi Expression of neuregulins and their putative receptors, ErbB2 and ErbB3, is induced during Wallerian degeneration
    S L Carroll
    Division of Neuropathology, Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 17:1642-59. 1997
    ....
  73. ncbi Molecular characterization of TRPA1 channel activation by cysteine-reactive inflammatory mediators
    Nobuaki Takahashi
    Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto, Japan
    Channels (Austin) 2:287-98. 2008
    ..Interestingly, the Cys421 mutation critically impaired the TRPA1 response to H(+) as well. Our findings suggest that TRPA1 channels are targeted by an array of inflammatory mediators to elicit inflammatory pain in the nervous system...
  74. ncbi Rescue of the cardiac defect in ErbB2 mutant mice reveals essential roles of ErbB2 in peripheral nervous system development
    J K Morris
    The Salk Institute, La Jolla, California 92037, USA
    Neuron 23:273-83. 1999
    ..However, these clusters are dispersed and morphologically different from those in control muscle. Our results reveal an important role for erbB2 during normal peripheral nervous system development...
  75. pmc Herpesviruses use bidirectional fast-axonal transport to spread in sensory neurons
    G A Smith
    Department of Molecular Biology, Schultz Building, Room 301, Princeton University, Princeton, NJ 08544 1014, USA
    Proc Natl Acad Sci U S A 98:3466-70. 2001
    ..The observed movement was compatible with fast axonal flow mediated by multiple microtubule motors. Capsids accumulated at axon terminals, suggesting that spread from infected neurons required cell contact...
  76. pmc Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery
    Chris Towne
    Brain Mind Institute, Ecole Polytechnique Federale de Lausanne, EPFL, Lausanne, Switzerland
    Mol Pain 5:52. 2009
    ..We have explored the capacity of recombinant AAV serotype 6 (rAAV2/6) to deliver genes to DRG neurons and characterized the transduction of nociceptors through five different routes of administration in mice...
  77. pmc NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy
    S D Dib-Hajj
    Department of Neurology, LCI 707, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 95:8963-8. 1998
    ....
  78. ncbi Impaired pressure sensation in mice lacking TRPV4
    Makoto Suzuki
    Department of Pharmacology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
    J Biol Chem 278:22664-8. 2003
    ..These data identify the TRPV4 channel as essential for the normal detection of pressure and as a receptor of the high-threshold mechanosensory complex...
  79. pmc Neuregulin-1 type III determines the ensheathment fate of axons
    Carla Taveggia
    Department of Cell Biology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Neuron 47:681-94. 2005
    ..These results indicate that levels of NRG1 type III, independent of axon diameter, provide a key instructive signal that determines the ensheathment fate of axons...
  80. ncbi Spatial and temporal relationship between monocyte chemoattractant protein-1 expression and spinal glial activation following peripheral nerve injury
    Ji Zhang
    Unite de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec, Canada
    J Neurochem 97:772-83. 2006
    ..Delayed, sustained astrocyte activation may participate with microglia in the persistent phase of pain hypersensitivity...
  81. ncbi Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy
    R E Study
    Dept of Anesthesia, Brigham and Women s Hospital Boston, MA 02115, USA
    Pain 65:235-42. 1996
    ....
  82. ncbi Distinct subpopulations of sensory afferents require F11 or axonin-1 for growth to their target layers within the spinal cord of the chick
    F E Perrin
    Pharmacenter, University of Basel, CH 4056, Basel, Switzerland
    Neuron 30:707-23. 2001
    ..Whereas nociceptive pathfinding depends on NgCAM and axonin-1, proprioceptive fibers require NrCAM and F11...
  83. ncbi Differential regulation of P2X(3) mRNA expression by peripheral nerve injury in intact and injured neurons in the rat sensory ganglia
    K Tsuzuki
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pain 91:351-60. 2001
    ..These data strongly suggest that P2X(3) mRNA expression increases in intact neurons and that P2X(3) mRNA in intact neurons may play a role in the pathomechanism of post-nerve injury in primary sensory neurons...
  84. ncbi Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury
    S D Novakovic
    Center for Biological Research, Roche Bioscience, Palo Alto, CA 94304 1397, USA
    Pain 80:273-82. 1999
    ..In addition, the spinal cord immunoreactivity increased in magnitude on the side ipsilateral to the ligated nerve, consistent with up-regulation of receptors in presynaptic terminals of the primary sensory neurons...
  85. ncbi Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain
    Sandra R Chaplan
    Neuroscience, Johnson and Johnson Pharmaceutical Research and Development, San Diego, California 92121, USA
    J Neurosci 23:1169-78. 2003
    ..These findings suggest novel insights into the molecular basis of pain and the possibility of new, specific, effective pharmacological therapies...
  86. ncbi Spinal glial activation and cytokine expression after lumbar root injury in the rat
    H Hashizume
    Department of Anesthesiology, Dartmouth Hitchcock Medical Center Lebanon, NH 03756 0001, USA
    Spine (Phila Pa 1976) 25:1206-17. 2000
    ..A further understanding of the immunologic consequences of root injury may lead to further development and the novel use of selective cytokine-inflammatory inhibitors for the treatment of low back pain associated with radiculopathy...
  87. pmc Properties and functions of calcium-activated K+ channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation
    A Scholz
    Physiologisches Institut, Justus Liebig Universitat Giessen, Aulweg 129, D 35392 Giessen, Germany
    J Physiol 513:55-69. 1998
    ..We suggest that the BKCa current is a possible mechanism of the reported conduction failure during repetitive stimulation in DRG neurones...
  88. ncbi Luminal hydrogen sulfide plays a pronociceptive role in mouse colon
    M Matsunami
    Division of Pharmacology and Pathophysiology, Kinki University School of Pharmacy, 3 4 1 Kowakae, Higashi Osaka 577 8502, Japan
    Gut 58:751-61. 2009
    ..Given recent evidence that hydrogen sulfide (H(2)S), a gasotransmitter, promotes somatic pain through redox modulation of T-type Ca(2+) channels, the roles of colonic luminal H(2)S in visceral nociceptive processing in mice were examined...
  89. ncbi PGE2 increases the tetrodotoxin-resistant Nav1.9 sodium current in mouse DRG neurons via G-proteins
    Anthony M Rush
    Department of Neurology, Yale University School of Medicine, LCI 707, 333 Cedar St, New Haven, CT 06510, USA
    Brain Res 1023:264-71. 2004
    ..Our data indicate that Na(v)1.9 current can be increased during inflammation via a G-protein dependent mechanism and suggest that this could contribute to the regulation of electrogenesis in dorsal root ganglia (DRG) neurons...
  90. ncbi Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals
    L Vulchanova
    Graduate Program in Neuroscience, University of Minnesota, Minneapolis 55455, USA
    Neuropharmacology 36:1229-42. 1997
    ..These results suggest species differences, although a more extensive study of primate sensory systems is necessary...
  91. ncbi LIM kinase and slingshot are critical for neurite extension
    Mitsuharu Endo
    Department of Biomolecular Sciences, Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8578, Japan
    J Biol Chem 282:13692-702. 2007
    ..These results suggest that proper regulation of cofilin/ADF activities through control of phosphorylation by LIMKs and SSHs is critical for neurite extension and that LIMKs regulate actin filament assembly at the tip of the growth cone...
  92. pmc Pirt, a phosphoinositide-binding protein, functions as a regulatory subunit of TRPV1
    Andrew Y Kim
    The Solomon H Snyder Department of Neuroscience, Center for Sensory Biology, School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    Cell 133:475-85. 2008
    ..Importantly, the enhancement of TRPV1 by PIP2 requires Pirt. Therefore, Pirt is a key component of the TRPV1 complex and positively regulates TRPV1 activity...
  93. ncbi Annexin II light chain regulates sensory neuron-specific sodium channel expression
    Kenji Okuse
    Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 417:653-6. 2002
    ..Because direct association with p11 is required for functional expression of Na(V)1.8, disrupting this interaction may be a useful new approach to downregulating Na(V)1.8 and effecting analgesia...
  94. ncbi A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells
    E Lingueglia
    Institut de Pharmacologie Moleculaire et Cellulaire, CNRS UPR 411, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 272:29778-83. 1997
    ..This sustained current is thought to be required for the tonic sensation of pain caused by acids...
  95. pmc Critical evaluation of the colocalization between calcitonin gene-related peptide, substance P, transient receptor potential vanilloid subfamily type 1 immunoreactivities, and isolectin B4 binding in primary afferent neurons of the rat and mouse
    Theodore J Price
    Department of Pharmacology, The University of Texas Health Science Center at San Antonio San Antonio, TX, USA
    J Pain 8:263-72. 2007
    ..Thus, whereas only an approximately 10% overlap was observed in TG neurons of mouse, significantly greater overlap (approximately 35%) was observed in those of rat...
  96. ncbi Inhibition of glycogen synthase kinase 3beta in sensory neurons in culture alters filopodia dynamics and microtubule distribution in growth cones
    Rebecca Owen
    The MRC Centre for Developmental Neurobiology, King s College London, Room 4 26B, New Hunts House, Guy s Campus, London SE1 1UL, UK
    Mol Cell Neurosci 23:626-37. 2003
    ..These results suggest that a major role of MAP1B in growing axons and growth cones is to regulate microtubule and actin filament stability. Furthermore, this function is regulated by phosphorylation of MAP1B by GSK-3beta...
  97. ncbi Spinal nerve ligation induces transient upregulation of tumor necrosis factor receptors 1 and 2 in injured and adjacent uninjured dorsal root ganglia in the rat
    M Schäfers
    Anesthesiology Research Laboratory, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0818, USA
    Neurosci Lett 347:179-82. 2003
    ..TNFR upregulation in injured and adjacent uninjured DRG neurons may be essential for mediating enhanced TNF effects and thus contribute to the development of pain-related behavior...
  98. ncbi Pulsed and continuous radiofrequency current adjacent to the cervical dorsal root ganglion of the rat induces late cellular activity in the dorsal horn
    Jan Van Zundert
    Department of Anesthesiology and Pain Management, University Hospital Maastricht, The Netherlands
    Anesthesiology 102:125-31. 2005
    ..This effect was not mediated by tissue heating. The authors investigated a possible late or long-term effect of three different radiofrequency modalities...
  99. ncbi Activation of p38 MAPK in primary afferent neurons by noxious stimulation and its involvement in the development of thermal hyperalgesia
    Toshiyuki Mizushima
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1 1 Mukogawa cho, Nishinomiya, Hyogo 663 8501, Japan
    Pain 113:51-60. 2005
    ....
  100. ncbi Regulation of nerve growth mediated by inositol 1,4,5-trisphosphate receptors in growth cones
    K Takei
    Calciosignal Net Project, Exploratory Research for Advanced Technology ERATO, Japan Science and Technology Corporation JST, Bunkyo ku, Tokyo 113 0021, Japan
    Science 282:1705-8. 1998
    ..IP3-induced Ca2+ release in growth cones appears to have a crucial role in control of nerve growth...
  101. ncbi Conditioning injury-induced spinal axon regeneration requires signal transducer and activator of transcription 3 activation
    Jin Qiu
    Wolfson Centre for Age Related Diseases, Guy s, King s, and St Thomas s School of Biomedical Science, King s College London, London SE1 1UL, United Kingdom
    J Neurosci 25:1645-53. 2005
    ..We conclude that STAT3 activation is necessary for increased growth ability of DRG neurons and improved axonal regeneration in the spinal cord after a conditioning injury...

Research Grants76

  1. Chronic Stress and Abdominal Pain: Novel Mechanisms
    John W Wiley; Fiscal Year: 2013
    ....
  2. Surgical Wound Repair: Role of A Neuroendothelial Axis
    NICOLE SIMONE GIBRAN; Fiscal Year: 2010
    ..We will employ siRNA to deplete neuropeptide receptors on endothelial cells to further define neural modulation of endothelial cell inflammatory responses, migration and proliferation. ..
  3. Abnormal Bone Marrow Cells and Diabetic Neuropathy
    Lawrence Chan; Fiscal Year: 2013
    ..The proposed research on the role and mechanism of high glucose-induced PI-BMDCs and PI-BMDC-neuron cell fusion may lead to a fundamental change in our understanding of the pathogenesis of diabetic neuropathy. ..
  4. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ....
  5. Epigenetic regulation in neuropathic pain
    Zhonghui Guan; Fiscal Year: 2013
    ..My department has guaranteed lab space and 80% of my professional time for my research, neither of which is contingent upon my receipt of this career award. ..
  6. Stress and Visceral Hyperalgesia: Epigenetic Mechanisms
    John W Wiley; Fiscal Year: 2012
    ..Therapeutic interventions that target epigenetic mechanisms are touted as a pathway to personalized medicine in the future. ..
  7. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..2) To determine if COG112 exerts neuroprotective and neurorestorative effects in vivo by functional and histological examination in a DPN model of BKS db/db mice. ..
  8. The role of trace metals and T-channels in pain
    Slobodan M Todorovic; Fiscal Year: 2013
    ....
  9. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..These studies will lay the groundwork for future experiments to examine novel therapeutics to treat exercise intolerance in this disease. ..
  10. MECHANICAL STIMULATION OF IVD CELLS
    Lori A Setton; Fiscal Year: 2013
    ....
  11. Varicella zoster virus-Induced Pain in a Rat Model of Post-Herpetic Neuralgia
    Paul R Kinchington; Fiscal Year: 2013
    ..The project may also identify new methods to alleviate PHN using gene therapy approaches. ..
  12. ALTERED SENSIBILITY FOLLOWING PERIPHERAL NERVE DAMAGE
    Clifford J Woolf; Fiscal Year: 2013
    ....
  13. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    ..These studies will lay the groundwork for future experiments to examine novel therapeutics to treat exercise intolerance in this disease. ..
  14. PERIPHERAL NEUROPATHY IN LENTIVIRUS INFECTIONS: EARLY VIRAL AND HOST DETERMINANTS
    Christopher Power; Fiscal Year: 2010
    ..Many of the scientific techniques and models to be employed in the experiments described herein are unique to the laboratories of this team of investigators who have worked together for many years. ..
  15. Mitochondrial Iron-Sulfur cluster mechanisms and therapy in Friedreich's ataxia
    Gino A Cortopassi; Fiscal Year: 2013
    ..abstract_text> ..
  16. Molecular, Genetic &Physiological Studies of Calcium-activated Chloride Channels
    Lily Y Jan; Fiscal Year: 2013
    ..We will also use a combination of approaches to determine the CaCC stoichiometry - an important question for better appreciation of CaCC function and regulation, and the diversity of CaCCs. ..
  17. Characterization of WNK function in Axonal Maintenance
    Erin L Filbert; Fiscal Year: 2012
    ....
  18. Tetrahydrobioperin acts as a pain signaling molecule
    Yessenia M Ibarra; Fiscal Year: 2012
    ..Identifying the actions of BH4 in the cell bodies of sensory neurons could lead to potential molecular targets for analgesics to relieve symptoms of chronic pain while eliminating side effects. ..
  19. Functional Interactions between Cancer Cells and Sensory Neurons
    DONALD SIMONE; Fiscal Year: 2012
    ..Understanding the mechanisms that drive cancer pain so that new and improved therapeutic approaches for pain management can be developed is a relevant public health issue. ..
  20. Mechanisms of Neuroinflammation after Fracture
    Wade S Kingery; Fiscal Year: 2013
    ....
  21. Identification, Development and Function of Rapidly Adapting Mechanoreceptors
    Wenqin Luo; Fiscal Year: 2010
    ..Insights from this study will be useful for guiding future strategies at promoting nerve regeneration after spinal cord injury. ..
  22. Novel Gene Targets for CNS Axonal Regeneration
    Vance P Lemmon; Fiscal Year: 2012
    ..The genes will be tested in neurons that cannot normally grow axons using cell culture and transplantation into animals to determine if the genes promote regeneration. ..
  23. KINASES IN ION COTRANSPORTER FUNCTION
    Eric J Delpire; Fiscal Year: 2013
    ....
  24. Endocannabinoid signaling in a model of cancer pain
    Virginia S Seybold; Fiscal Year: 2013
    ..Cannabinoids are potent analgesics, and manipulation of the metabolism of endogenous cannabinoids may provide an effective strategy for reducing mechanical hypersensitivity in patients where destruction of bone is involved. ..
  25. Synapse Loss in Spinal Muscular Atrophy
    Chien Ping Ko; Fiscal Year: 2010
    ..The proposed research would lead to future development of novel therapies for SMA by targeting synaptic defects in the spinal cord. ..
  26. Neural Plasticity and Inflammatory Pain
    Clifford J Woolf; Fiscal Year: 2013
    ....
  27. Molecular mechanisms in controlling development of touch-sensing neurons
    Wenqin Luo; Fiscal Year: 2013
    ..Results from this research will greatly improve our understanding of how mammalian mechanoreceptors develop and provide insight into axonal regeneration after injuries. ..
  28. Airway Sensory Neuroexcitability
    Bradley J Undem; Fiscal Year: 2013
    ..We expect that this information will help build the framework from which future studies may be based that are aimed at understanding the role that these important nerves play in health and disease. ..
  29. Identification, Development and Function of Rapidly Adapting Mechanoreceptors
    Wenqin Luo; Fiscal Year: 2013
    ..Together, these new assays and reagent will enable me to address the role of RA mechanoreceptors and, in the future additional populations of DRG neurons during tactile discrimination. ..
  30. Neural and Chemical Basis of Pathological Pain
    Jun Ming Zhang; Fiscal Year: 2013
    ..Because inflammatory processes play a role in many types of chronic pain, the findings will be relevant not only to understanding low back pain, but other types of pain as well. ..
  31. Regulation of (Ca2+)i oscillation and osteoclast differentiation by RGS12
    Shuying Yang; Fiscal Year: 2010
    ..Aim 3. To define the role and mechanism of RGS12 in vivo in bone remodeling by osteoclast-specific targeted disruption of the RGS12 gene using Cre/loxP technology! ..
  32. Mechanisms of postnatal cutaneous afferent development during inflammation
    Michael P Jankowski; Fiscal Year: 2013
    ..These and future studies will allow us to better understand how changes in sensory fibers impact pediatric pain and may also lead to the establishment of more suitable treatments for pain in children. ..
  33. Sigma 1 receptor as a master regulator of pronociceptive protein trafficking in t
    Jay Yang; Fiscal Year: 2013
    ....
  34. Selective targeting of sodium channel blockers to pain-sensing neurons
    Bruce P Bean; Fiscal Year: 2012
    ..Such treatments should be highly advantageous for more selective pain relief in childbirth, surgery, and dental procedures and possibly for some forms of chronic neurogenic pain. ..
  35. Pathogenesis and Therapy of HIV-Related Neuropathic Pain
    Shuanglin Hao; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: proposal will investigate the mechanism of HIV-related neuropathic pain. The study may provide a new approach to treatment of HIV-related pain. ..
  36. Acute and Chronic Afferent Engagement: Sympathetic and End Organ Responses
    Lawrence I Sinoway; Fiscal Year: 2013
    ..Two cores are proposed: 1) Core A will be administrative;and 2) Core B will be a human physiology core. ..
  37. Mixed NOP/mu compounds and the involvement of their receptors in analgesia.
    LAWRENCE R TOLL; Fiscal Year: 2013
    ....
  38. Investigation of herpes simplex virus -1 neurotropism in SCID DRG xenografts
    Ann M Arvin; Fiscal Year: 2010
    ..Our goal is to develop a model to study how HSV-1 infects human nerve cells that will have potential value for developing new drugs and vaccines. ..
  39. Exercise, neurotrophins, and axon regeneration in the PNS
    Arthur W English; Fiscal Year: 2013
    ..At the end of this study we will have acquired evidence in support of three significant aspects of the efficacy of exercise that will add to its translational promise. ..
  40. Role of Myelin in Spinal Cord Regeneration
    Marie T Filbin; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: The identification of novels agents/mechanisms that promote axonal regeneration will reveal novel targets for therapeutic intervention and drug development to promote axonal regeneration in humans. ..
  41. Analgesics Targeting TRPA1 for Treatment of Chronic Pain
    JEFF MARK HERZ; Fiscal Year: 2011
    ..Our approach can identify TRPA1 ligands which are classical antagonists, desensitizing agonists, inverse agonists and allosteric modulators. ..
  42. Mechanisms of Muscle Afferent Sensitization after Ischemia
    Michael P Jankowski; Fiscal Year: 2013
    ..This may lead to the formulation of more appropriate treatments for musculoskeletal pain associated with ischemia/ reperfusion that target the proper pain receptor(s) or primary afferent subpopulation(s). ..
  43. Epigenetic Mechanisms of Neuropathic Pain
    Hui Lin Pan; Fiscal Year: 2013
    ..In addition, our project may provide novel information, which could lead to the development of new epigenetic therapeutic agents to prevent and treat chronic neuropathic pain. ..
  44. Neuronal regulation of myelination
    ROMAN JENO GIGER; Fiscal Year: 2013
    ..Restoration of myelination by Fig4 gene therapy in mice would demonstrate a new therapeutic avenue for patients suffering from myelination disorders. ..
  45. Control of Arthritic Pain by Inhibition of TRPA1 Activity
    JEFF MARK HERZ; Fiscal Year: 2013
    ..The anticipated Phase 2 program will consist of animal efficacy testing in multiple OA models and conducting pharmacokinetic studies in multiple animal species using oral dosing to enable the filing of an IND. ..
  46. Nerve Growth Factor Signaling in Painful Diabetic Neuropathy
    Hsinlin Thomas Cheng; Fiscal Year: 2013
    ..In this proposal we seek to identify new therapeutic targets for DNP based upon a more thorough understanding of the pathogenesis of this disorder. ..
  47. MrgprC, A New Target for the Treatment of Neuropathic Pain
    Yun Guan; Fiscal Year: 2013
    ..Current study may identify a new pain-specific treatment target and lead to a novel mechanism-based approach to the treatment of neuropathic pain. ..
  48. Evaluating the role of NRG-1 receptors in MPNST tumorigenesis
    STEPHANIE NICOLE BROSIUS; Fiscal Year: 2013
    ..The work proposed here will attempt to isolate the tumor initiating cells and understand the key signaling cascades required for tumor development in order to identify potential chemotherapeutic targets. ..
  49. Ionic Mechanisms Underlying Dorsal Root Ganglion Excitability
    Arindam Bhattacharjee; Fiscal Year: 2013
    ..This research project will assess the involvement of KNa channels in the diabetic neuropathy. ..
  50. Pain and Endometriosis: Effects on Ectopic Cyst Innervation and Axons
    Geoffrey M Bove; Fiscal Year: 2010
    ..As a result of this research, consideration and specific examination of nerves within the pelvis during ablative laparoscopic techniques may become an important additional diagnostic procedure for women with endometriosis. ..
  51. VOLATILE ANESTHETICS AND NEURONAL CALCIUM
    THOMAS JOSEPH JOHN BLANCK; Fiscal Year: 2010
    ..The results of these studies will yield important molecular insights into Ca2+ signaling in neurons and clarify the relevance of VA effects on Ca2+ signaling to the immobility aspect of VA-mediated anesthesia. ..
  52. Nociceptive Mechanisms in Whiplash Injury
    Beth A Winkelstein; Fiscal Year: 2013
    ..Physiologic correlates of these injuries and symptoms are also characterized to guide future development of preventions and treatments for neck pain from this common class of injuries for vehicle occupants. ..
  53. Epigenetic regulation of neuropathic pain: Role of native KV1.2 antisense RNA
    Yuan Xiang Tao; Fiscal Year: 2013
    ..The proposed studies will provide major conceptual advances to our understanding of the molecular mechanism of neuropathic pain and might open a door for developing new strategies for treating neuropathic pain. ..
  54. Sodium Channels in Spinal Cord Injury, Nerve Injury and Neuropathic Pain
    Stephen Waxman; Fiscal Year: 2013
    ..Our aim is to discover molecules that affect DRG neuron behavior, so that we can identify more effective treatments for neuropathic and inflammatory pain. ..
  55. Group III mGLURs: Mechanisms of Analgesia
    Susan M Carlton; Fiscal Year: 2013
    ....
  56. Purinergic G protein signal integration in nociceptors
    Derek C Molliver; Fiscal Year: 2013
    ....
  57. Cerebrovascular Afferent Mechanisms of Migraine
    ANDREA MARIE HARRIOTT; Fiscal Year: 2010
    ..The results from these experiments should help provide unique targets for the treatment of migraine pain and increase the understanding of cerebrovascular afferent mechanisms in initiating migraine pain. ..
  58. Neuromodulation of Kv3.4 channels in nociceptors
    MANUEL L COVARRUBIAS; Fiscal Year: 2013
    ..4 channel signaling microdomain that includes GPCRs, second messenger molecules and PKC;and 3) setting the stage to develop new and more effective therapeutic strategies that may help alleviate neuropathic pain. ..
  59. Contribution of Sigma Receptor Activation to Neuropathic Pain
    Hsiang En Wu; Fiscal Year: 2013
    ..RELEVANCE (See instructions): Exploration of the contributions of al R in prinnary sensory neurons to pain sensation may provide a new therapeutic pathway for pain conditions that are resistant to currently available treatments...
  60. Resolution of chemotherapy-induced peripheral neuropathy by novel lipid mediator
    Zhen Zhong Xu; Fiscal Year: 2013
    ..We believe this application will demonstrate novel molecular and cellular mechanisms of CIPN and help develop new therapy for treating chronic pain associated with CIPN. ..
  61. The mechanisms of action of T-lymphocytes in neuropathic pain
    Michael Costigan; Fiscal Year: 2013
    ....
  62. Carbonic Anhydrase 8 and Susceptibility to the Acute to Chronic Pain Transition
    Eugene S Fu; Fiscal Year: 2012
    ..Additionally, these studies may help us to understand treatment resistance and avert long-term drug dependence. ..
  63. DNA Methylation Profiling of Chronic Pain
    Andreas S Beutler; Fiscal Year: 2010
    ..Research outcomes of Aims 1 and 2 will be confirmed in an independent set of animals. If conducted now, the proposed study would be the first to investigate DNA cytosine methylation in pain. ..
  64. APOE3 AND APOE4 EFFECTS ON CELLULAR PATHOBIOLOGY
    ROBERT PITAS; Fiscal Year: 1999
    ....
  65. Growth Factor-Induced Peripheral Gliogenesis
    Donald Pizzo; Fiscal Year: 2007
    ..Furthermore, the development of a quantitative tumor model allows for the assessment of small molecule therapeutics in a pre-clinical setting. [unreadable] [unreadable]..
  66. Sensory Plasticity During Central Neuropathic Pain Caused by Spinal Cord Injury
    Edgar T Walters; Fiscal Year: 2010
    ..The proposed studies will test the hypothesis that chronic pain caused by spinal cord injury is produced in part by spontaneous electrical activity in sensory neurons, and that pain may be reduced by blocking this activity. ..
  67. DIRECT NEUROTOXICITY OF LOCAL ANESTHETICS
    Michael Johnson; Fiscal Year: 2002
    ..The Ca2+cyt dependence of each mechanism of mitochondrial injury will be determined by experiments with and without Ca2+cyt clamped at a normal level. ..
  68. IGF-I PROTECTS NEURONS FROM GLUCOSE INDUCED CELL DEATH
    James Russell; Fiscal Year: 2001
    ..The current proposal will help elucidate the mechanisms underlying the role of IGF-I in preventing changes in neuronal morphology and PCD in diabetic neuropathy. ..
  69. DYNORPHIN MODULATES CGRP RELEASE VIA PKC
    Zaijie Jim Wang; Fiscal Year: 2003
    ..Frank Porreca and Josephine Lai. This award is consistent with the long-term career goal of the candidate to become an independent investigator contributing to the basic research of pain and opioid pharmacology. ..
  70. ROLE OF NEUREGULIN ON AXON/GLIA INTERACTIONS IN DIABETES
    TIMOTHY RAABE; Fiscal Year: 2000
    ..Indeed, the neuroprotective properties of neuregulins have been described in nerve crush and cisplatin-induced neuropathy. Their clinical importance in diabetic neurpathy, however, has not yet been investigated. ..
  71. DORSAL ROOT GANGLION AS SOURCE OF NEUROPATHIC PAIN
    Thomas Baumann; Fiscal Year: 2001
    ..Together, the proposed studies are expected to provide new information about the DRG as a peripheral source of neuropathic pain. The results will form the basis of a planned RO1 research proposal. ..
  72. AXONAL REGENERATION IN SPINAL CORD
    RAYMOND LASEK; Fiscal Year: 1991
    ....
  73. NEUROTROPIC RETROVIRUSES
    LAWRENCE WHALEN; Fiscal Year: 1993
    ..A biologically defined FIV model for lentivirus-induced neurologic disease will be established using MC-FIVs, and we will begin to define the genetic structures of neurotropic FIVs. ..
  74. ESTROGENIC REGULATION OF GENE EXPRESSION DURING NEURONAL
    Monica Oblinger; Fiscal Year: 1999
    ....
  75. PARTIAL RHIZOTOMY EFFECTS ON SPINAL GANGLIA
    ROBERT LA MOTTE; Fiscal Year: 2002
    ....
  76. NR/CAM AND FORMATION OF NODE OF RANVIER
    Martin Grumet; Fiscal Year: 2002
    ..In the future, such information may lead to new therapeutic strategies to prevent injury and restore function in myelinated nerves that become damaged and remyelinated in multiple sclerosis. ..