spinal cord

Summary

Top Publications

  1. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
  2. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
  3. doi Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
    T J Kwiatkowski
    Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Science 323:1205-8. 2009
  4. pmc Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    Kristina A Kigerl
    Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 29:13435-44. 2009
  5. pmc Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    Caroline Vance
    Department of Clinical Neuroscience, King s College London, Medical Research Council MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London SE5 8AF, UK
    Science 323:1208-11. 2009
  6. ncbi Directed differentiation of embryonic stem cells into motor neurons
    Hynek Wichterle
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 110:385-97. 2002
  7. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
  8. ncbi Revised diagnostic criteria for neuromyelitis optica
    D M Wingerchuk
    Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Neurology 66:1485-9. 2006
  9. pmc Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
    Han Xiang Deng
    Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 477:211-5. 2011
  10. pmc IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    Vanda A Lennon
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 202:473-7. 2005

Research Grants

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
  2. Yasmin Wadia; Fiscal Year: 2014
  3. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
  4. Ashraf Gorgey; Fiscal Year: 2016
  5. Patrice G Guyenet; Fiscal Year: 2015
  6. ANTHONY JOHN KANAI; Fiscal Year: 2016
  7. ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2014
  8. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
  9. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
  10. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013

Detail Information

Publications435 found, 100 shown here

  1. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
    ..C-terminal fragments and was recovered only from affected central nervous system regions, including hippocampus, neocortex, and spinal cord. TDP-43 represents the common pathologic substrate linking these neurodegenerative disorders.
  2. ncbi Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
    M E Gurney
    Department of Cell and Molecular Biology, Northwestern University Medical School, Chicago, IL 60611
    Science 264:1772-5. 1994
    ..The mice became paralyzed in one or more limbs as a result of motor neuron loss from the spinal cord and died by 5 to 6 months of age...
  3. doi Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
    T J Kwiatkowski
    Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Science 323:1205-8. 2009
    ..Neuronal cytoplasmic protein aggregation and defective RNA metabolism thus appear to be common pathogenic mechanisms involved in ALS and possibly in other neurodegenerative disorders...
  4. pmc Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord
    Kristina A Kigerl
    Center for Brain and Spinal Cord Repair, Ohio State University, Columbus, Ohio 43210, USA
    J Neurosci 29:13435-44. 2009
    ..Here, we show that an M1 macrophage response is rapidly induced and then maintained at sites of traumatic spinal cord injury and that this response overwhelms a comparatively smaller and transient M2 macrophage response...
  5. pmc Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    Caroline Vance
    Department of Clinical Neuroscience, King s College London, Medical Research Council MRC Centre for Neurodegeneration Research, Institute of Psychiatry, London SE5 8AF, UK
    Science 323:1208-11. 2009
    ..FUS is involved in the regulation of transcription and RNA splicing and transport, and it has functional homology to another ALS gene, TARDBP, which suggests that a common mechanism may underlie motor neuron degeneration...
  6. ncbi Directed differentiation of embryonic stem cells into motor neurons
    Hynek Wichterle
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA
    Cell 110:385-97. 2002
    ..ES cell-derived motor neurons can populate the embryonic spinal cord, extend axons, and form synapses with target muscles...
  7. ncbi Descending control of pain
    Mark J Millan
    Department of Psychopharmacology, Institut de Recherches Servier, 125 Chemin de Ronde, 78290 Croissy Seine, Paris, France
    Prog Neurobiol 66:355-474. 2002
    Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling) information from the viscera, skin and other organs is subject to extensive processing by a diversity of mechanisms, certain of which enhance, and ..
  8. ncbi Revised diagnostic criteria for neuromyelitis optica
    D M Wingerchuk
    Department of Neurology, Mayo Clinic College of Medicine, Scottsdale, AZ 85259, USA
    Neurology 66:1485-9. 2006
    ..However, some patients with otherwise typical NMO have additional symptoms not attributable to optic nerve or spinal cord inflammation or have MS-like brain MRI lesions...
  9. pmc Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
    Han Xiang Deng
    Division of Neuromuscular Medicine, Davee Department of Neurology and Clinical Neurosciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    Nature 477:211-5. 2011
    ..sclerosis (ALS) is a paralytic and usually fatal disorder caused by motor-neuron degeneration in the brain and spinal cord. Most cases of ALS are sporadic but about 5-10% are familial...
  10. pmc IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
    Vanda A Lennon
    Department of Immunology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Exp Med 202:473-7. 2005
    Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that selectively affects optic nerves and spinal cord. It is considered a severe variant of multiple sclerosis (MS), and frequently is misdiagnosed as MS, but prognosis ..
  11. ncbi BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    Jeffrey A M Coull
    Division de Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 438:1017-21. 2005
    ..that occurs after peripheral nerve injury depends on the hyperexcitability of neurons in the dorsal horn of the spinal cord. Spinal microglia stimulated by ATP contribute to tactile allodynia, a highly debilitating symptom of pain ..
  12. pmc Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury
    Hideaki Nakajima
    Department of Orthopaedics and Rehabilitation Medicine, University of Fukui Faculty of Medical Sciences, Fukui, Japan
    J Neurotrauma 29:1614-25. 2012
    Mesenchymal stem cells (MSC) derived from bone marrow can potentially reduce the acute inflammatory response in spinal cord injury (SCI) and thus promote functional recovery...
  13. pmc Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
    Osahiko Tsuji
    Department of Physiology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 107:12704-9. 2010
    ..show the directed neural differentiation of murine iPS cells and examine their therapeutic potential in a mouse spinal cord injury (SCI) model...
  14. pmc Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
    Koji Yamanaka
    Ludwig Institute for Cancer Research and Department of Medicine and Neuroscience, University of California at San Diego, 9500 Gilman Drive, La Jolla, California 92093 0670, USA
    Nat Neurosci 11:251-3. 2008
    ..These findings demonstrate that mutant astrocytes are viable targets for therapies for slowing the progression of non-cell autonomous killing of motor neurons in ALS...
  15. pmc Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel
    PLoS Med 6:e1000113. 2009
    Although macrophages (MPhi) are known as essential players in wound healing, their contribution to recovery from spinal cord injury (SCI) is a subject of debate...
  16. doi Proposed chronic cerebrospinal venous insufficiency criteria do not predict multiple sclerosis risk or severity
    Diego Centonze
    Department of Neuroscience, University Hospital Tor Vergata, Rome, Italy
    Ann Neurol 70:51-8. 2011
    ..This information is particularly relevant, because uncontrolled surgical procedures are increasingly offered to MS patients to treat their venous stenoses...
  17. ncbi Requirement for the homeobox gene Hb9 in the consolidation of motor neuron identity
    S Arber
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    Neuron 23:659-74. 1999
    ..In embryonic chick spinal cord, the ectopic expression of MNR2 or Hb9 is sufficient to trigger MN differentiation and to repress the ..
  18. ncbi Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain
    Jeffrey A M Coull
    Neurobiologie Cellulaire, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec G1J 2G3, Canada
    Nature 424:938-42. 2003
    Modern pain-control theory predicts that a loss of inhibition (disinhibition) in the dorsal horn of the spinal cord is a crucial substrate for chronic pain syndromes...
  19. ncbi Vertebrate neurogenesis is counteracted by Sox1-3 activity
    Magdalena Bylund
    Ludwig Institute of Cancer Research, Karolinska Institute, Box 240, SE 171 77 Stockholm, Sweden
    Nat Neurosci 6:1162-8. 2003
    ..These data suggest that the generation of neurons from stem cells depends on the inhibition of Sox1-3 expression by proneural proteins...
  20. pmc Populations of inhibitory and excitatory interneurons in lamina II of the adult rat spinal dorsal horn revealed by a combined electrophysiological and anatomical approach
    Toshiharu Yasaka
    Neuroscience and Molecular Pharmacology, Faculty of Biomedical and Life Sciences, University of Glasgow, Glasgow, UK
    Pain 151:475-88. 2010
    ..electrophysiological and pharmacological properties for 61 lamina II neurons recorded in slices from adult rat spinal cord. Morphology was related to transmitter content, since islet cells were GABAergic, while radial and most ..
  21. ncbi Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis
    Shanu F Roemer
    Department of Neurology, Mayo Clinic, College of Medicine, 200 First St SW, Rochester, MN 55905, USA
    Brain 130:1194-205. 2007
    Neuromyelitis optica (NMO) is an inflammatory demyelinating disease that typically affects optic nerves and spinal cord. Its pathogenic relationship to multiple sclerosis (MS) is uncertain...
  22. pmc Optogenetic dissection of a behavioural module in the vertebrate spinal cord
    Claire Wyart
    Helen Wills Neuroscience Institute and Department of Molecular and Cell Biology, University of California in Berkeley, Berkeley, California 94720, USA
    Nature 461:407-10. 2009
    ..drive for inducing the spinal CPG can originate from either supraspinal glutamatergic inputs or from within the spinal cord. Here we identify a spinal input to the CPG that drives spontaneous locomotion using a combination of ..
  23. doi Progressive multiple sclerosis is not associated with chronic cerebrospinal venous insufficiency
    C Baracchini
    First Neurology Clinic, Department of Neuroscience, University of Padua, Padova, Italy
    Neurology 77:844-50. 2011
    ..Thus, we studied CCSVI prevalence in primary progressive (PP) and secondary progressive (SP) MS, to clarify whether CCSVI characterizes the progressive forms of this disease...
  24. doi Restoring voluntary control of locomotion after paralyzing spinal cord injury
    Rubia van den Brand
    Neurology Department, University of Zurich, Ch 8008 Zurich, Switzerland
    Science 336:1182-5. 2012
    Half of human spinal cord injuries lead to chronic paralysis. Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally mediated movements in rats with paralyzing lesions...
  25. pmc Targeted depletion of TDP-43 expression in the spinal cord motor neurons leads to the development of amyotrophic lateral sclerosis-like phenotypes in mice
    Lien Szu Wu
    Institute of Molecular Biology, Academia Sinica, Taipei 11574, Taiwan
    J Biol Chem 287:27335-44. 2012
    ..the conditional mouse gene targeting approach, we show that mice with inactivation of the Tardbp gene in the spinal cord motor neurons (HB9:Cre-Tardbp(lx/-)) exhibit progressive and male-dominant development of ALS-related ..
  26. pmc Long-distance growth and connectivity of neural stem cells after severe spinal cord injury
    Paul Lu
    Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA
    Cell 150:1264-73. 2012
    ..GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury...
  27. ncbi Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation
    Annemarie Ledeboer
    Department of Psychology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 345, Boulder, CO 80309 0345, USA
    Pain 115:71-83. 2005
    Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating enhanced pain states by releasing proinflammatory cytokines and other substances thought to facilitate pain transmission...
  28. pmc A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica
    Claudia F Lucchinetti
    Department of Neurology, Mayo Clinic, Rochester, MN, USA
    Brain 125:1450-61. 2002
    ..mechanisms that result in selective localization of inflammatory demyelinating lesions to the optic nerves and spinal cord are unknown...
  29. ncbi Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
    A M Clement
    Ludwig Institute for Cancer Research, University of California, 9500 Gilman Drive, La Jolla, CA 92093 0670, USA
    Science 302:113-7. 2003
    ..Normal motor neurons in SOD1 mutant chimeras develop aspects of ALS pathology. Most important, nonneuronal cells that do not express mutant SOD1 delay degeneration and significantly extend survival of mutant-expressing motor neurons...
  30. pmc Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2
    Catherine Abbadie
    Department of Pharmacology, Merck Research Laboratories, P O Box 2000, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 100:7947-52. 2003
    ..Chronic pain also resulted in the appearance of activated CCR2-positive microglia in the spinal cord. Collectively, these data suggest that the recruitment and activation of macrophages and microglia peripherally ..
  31. pmc Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
    Xiu Shan
    Department of Pathology, Division of Neuropathology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 2196, USA
    Proc Natl Acad Sci U S A 107:16325-30. 2010
    ..In concert, our findings indicate that TDP-43 participates in pathways critical for motor neuron physiology, including those that regulate the normal distributions of SMN-associated GEMs in the nucleus and mitochondria in the cytoplasm...
  32. ncbi Neuropilin is a semaphorin III receptor
    A L Kolodkin
    Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2185, USA
    Cell 90:753-62. 1997
    ..We also describe the identification of neuropilin-2, a related neuropilin family member, and show that neuropilin and neuropilin-2 are expressed in overlapping, yet distinct, populations of neurons in the rat embryonic nervous system...
  33. ncbi Neuronal specification in the spinal cord: inductive signals and transcriptional codes
    T M Jessell
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Nat Rev Genet 1:20-9. 2000
    ..The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules...
  34. ncbi Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, 3600 Spruce Street, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neuron 34:521-33. 2002
    ..These mice demonstrate that A53T alpha-synuclein leads to the formation of toxic filamentous alpha-synuclein neuronal inclusions that cause neurodegeneration...
  35. pmc Effect of epidural stimulation of the lumbosacral spinal cord on voluntary movement, standing, and assisted stepping after motor complete paraplegia: a case study
    Susan Harkema
    Department of Neurological Surgery, Kentucky Spinal Cord Research Center, University of Louisville, KY, USA
    Lancet 377:1938-47. 2011
    Repeated periods of stimulation of the spinal cord and training increased the ability to control movement in animal models of spinal cord injury...
  36. pmc Circuits controlling vertebrate locomotion: moving in a new direction
    Martyn Goulding
    Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Rev Neurosci 10:507-18. 2009
    ..The motor circuits in the spinal cord that control locomotion, commonly referred to as central pattern generator networks, provide an experimentally ..
  37. doi Down-regulation of the potassium-chloride cotransporter KCC2 contributes to spasticity after spinal cord injury
    Pascale Boulenguez
    Laboratoire Plasticité et Physio Pathologie de la Motricité UMR6196, Centre National de la Recherche Scientifique CNRS and Aix Marseille Université, Marseille, France
    Nat Med 16:302-7. 2010
    ..of spinal reflexes and reduced synaptic inhibition are commonly associated with spasticity after spinal cord injury (SCI)...
  38. pmc Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice
    Ya Fei Xu
    Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Neurosci 30:10851-9. 2010
    ..driven by the mouse prion promoter to provide a tool to analyze the role of wild-type hTDP-43 in the brain and spinal cord. Expression of hTDP-43 caused a dose-dependent downregulation of mouse TDP-43 RNA and protein...
  39. ncbi Glial activation: a driving force for pathological pain
    L R Watkins
    Dept of Psychology and the Center for Neurosciences, University of Colorado at, Boulder, CO, USA
    Trends Neurosci 24:450-5. 2001
    ..The discovery that spinal cord glia (microglia and astrocytes) amplify pain requires a change in this view...
  40. ncbi p38 mitogen-activated protein kinase is activated after a spinal nerve ligation in spinal cord microglia and dorsal root ganglion neurons and contributes to the generation of neuropathic pain
    Shan Xue Jin
    Neural Plasticity Research Group, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    J Neurosci 23:4017-22. 2003
    The possible involvement of p38 mitogen-activated protein kinase activation in spinal cord and dorsal root ganglion (DRG) cells in the development of peripheral neuropathic pain has been explored...
  41. ncbi Opposing FGF and retinoid pathways control ventral neural pattern, neuronal differentiation, and segmentation during body axis extension
    Ruth Diez del Corral
    Division of Cell and Developmental Biology, Faculty of Life Sciences, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom
    Neuron 40:65-79. 2003
    ..Our data demonstrate that FGF and RA pathways are mutually inhibitory and suggest that their opposing actions provide a global mechanism that controls differentiation during axis extension...
  42. ncbi Locomotor circuits in the mammalian spinal cord
    Ole Kiehn
    Mammalian Locomotor Laboratory, Department of Neuroscience, Karolinska Institutet, Stockholm S17177, Sweden
    Annu Rev Neurosci 29:279-306. 2006
    ..Molecular and genetic approaches that have the potential to elucidate the function of populations of CPG interneurons are also discussed...
  43. pmc T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
    Isaac M Chiu
    Department of Pathology, Immune Disease Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 105:17913-8. 2008
    ..These results indicate that T cells play an endogenous neuroprotective role in ALS by modulating a beneficial inflammatory response to neuronal injury...
  44. pmc Disability, atrophy and cortical reorganization following spinal cord injury
    Patrick Freund
    Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK
    Brain 134:1610-22. 2011
    The impact of traumatic spinal cord injury on structural integrity, cortical reorganization and ensuing disability is variable and may depend on a dynamic interaction between the severity of local damage and the capacity of the brain for ..
  45. doi Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis
    Shoichi Sasaki
    Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
    J Neuropathol Exp Neurol 70:349-59. 2011
    ..Thus, autophagy seems to be activated and upregulated in the cytoplasm of motor neurons and may be involved in the mechanisms of neurodegeneration of motor neurons in sporadic ALS...
  46. ncbi Presynaptic inhibition in the vertebrate spinal cord revisited
    P Rudomin
    Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Apartado Postal 14 740, Mexico DF 07000, Mexico
    Exp Brain Res 129:1-37. 1999
    ..the existence of central mechanisms able to modulate the synaptic effectiveness of sensory fibers ending in the spinal cord of vertebrates...
  47. doi Blood-brain barrier disruption and enhanced vascular permeability in the multiple sclerosis model EAE
    Jami Bennett
    University of British Columbia, Biomedical Research Centre, Vancouver, British Columbia, Canada
    J Neuroimmunol 229:180-91. 2010
    ....
  48. ncbi Muscle synergies encoded within the spinal cord: evidence from focal intraspinal NMDA iontophoresis in the frog
    P Saltiel
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurophysiol 85:605-19. 2001
    ..To search for a common set of synergies encoded for by the spinal cord whose combinations would account for a large range of electromyographic (EMG) patterns, we chose, rather than ..
  49. doi Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain
    Xiao Xiu Qu
    Neuroscience Research Institute and Department of Neurobiology, Peking University, 38 Xue Yuan Road, Beijing 100191, PR China
    Exp Neurol 215:298-307. 2009
    ..electrophysiological recording in L5 spinal nerve-ligated (SNL) neuropathic rats, we investigate the roles of spinal cord NMDA-2B receptors in the development of neuropathic pain. Our study showed that intrathecal (i.t...
  50. pmc Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord
    Yasuhiko Kawasaki
    Pain Research Center, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 28:5189-94. 2008
    Central sensitization, increased sensitivity in spinal cord dorsal horn neurons after injuries, plays an essential role in the induction and maintenance of chronic pain...
  51. ncbi Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling
    Anna I Lyuksyutova
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Science 302:1984-8. 2003
    Commissural neurons in the mammalian dorsal spinal cord send axons ventrally toward the floor plate, where they cross the midline and turn anteriorly toward the brain; a gradient of chemoattractant(s) inside the spinal cord controls this ..
  52. ncbi Impaired nociception and pain sensation in mice lacking the capsaicin receptor
    M J Caterina
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143 0450, USA
    Science 288:306-13. 2000
    ..Thus, VR1 is essential for selective modalities of pain sensation and for tissue injury-induced thermal hyperalgesia...
  53. doi Individual premotor drive pulses, not time-varying synergies, are the units of adjustment for limb trajectories constructed in spinal cord
    William J Kargo
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania 19129, USA
    J Neurosci 28:2409-25. 2008
    ..Our studies support individual premotor drive pulses or bursts as execution primitives in spinal cord. Alternatively, the fundamental execution primitives at the segmental level could be time-varying synergies...
  54. doi Acupuncture-mediated inhibition of inflammation facilitates significant functional recovery after spinal cord injury
    Doo C Choi
    Age Related and Brain Diseases Research Center, School of Medicine, Kyung Hee University, Seoul, Korea
    Neurobiol Dis 39:272-82. 2010
    ....
  55. doi Central mechanisms of pathological pain
    Rohini Kuner
    Pharmacology Institute, University of Heidelberg, Im Neuenheimer Feld, 366 Heidelberg, Germany
    Nat Med 16:1258-66. 2010
    ..This review focuses on the molecular determinants of network plasticity in the central nervous system (CNS) and discusses their relevance to the development of new therapeutic approaches...
  56. pmc Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury
    Farida Hellal
    Axonal Growth and Regeneration Group, Max Planck Institute of Neurobiology, Martinsried, Germany
    Science 331:928-31. 2011
    Hypertrophic scarring and poor intrinsic axon growth capacity constitute major obstacles for spinal cord repair. These processes are tightly regulated by microtubule dynamics...
  57. pmc Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders
    Adam K Bevan
    Center for Gene Therapy, The Research Institute at Nationwide Children s Hospital, Columbus, Ohio 43205, USA
    Mol Ther 19:1971-80. 2011
    ..primarily in glial cells throughout the brain, dorsal root ganglia neurons and motor neurons within the spinal cord, providing confidence for translation to SMA patients...
  58. pmc Emergence of patterned activity in the developing zebrafish spinal cord
    Erica Warp
    Helen Wills Neuroscience Graduate Program, University of California, Berkeley, Berkeley, CA 94720, USA
    Curr Biol 22:93-102. 2012
    ..In the spinal cord, it is poorly understood how correlated activity is acquired and how its emergence relates to the formation of ..
  59. doi TRPV1 in GABAergic interneurons mediates neuropathic mechanical allodynia and disinhibition of the nociceptive circuitry in the spinal cord
    Yong Ho Kim
    National Research Laboratory for Pain, Dental Research Institute and Department of Neurobiology and Physiology, School of Dentistry, Seoul National University, Seoul 110 749, Republic of Korea
    Neuron 74:640-7. 2012
    ..resulting from long-term depression (LTD) of GABAergic interneurons as a consequence of TRPV1 activation in the spinal cord. Intrathecal administration of TRPV1 agonists led to mechanical allodynia that was not dependent on peripheral ..
  60. doi Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood-spinal cord barrier after spinal cord injury
    Jee Y Lee
    Age Related and Brain Diseases Research Centre, School of Medicine, Kyung Hee University, Seoul 130 701, Korea
    Brain 135:2375-89. 2012
    After spinal cord injury, the disruption of blood-spinal cord barrier by activation of matrix metalloprotease is a critical event leading to infiltration of blood cells, inflammatory responses and neuronal cell death, contributing to ..
  61. pmc Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
    Ravid Shechter
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Immunity 38:555-69. 2013
    Monocyte-derived macrophages are essential for recovery after spinal cord injury, but their homing mechanism is poorly understood...
  62. pmc Chronic cerebrospinal venous insufficiency in multiple sclerosis: clinical correlates from a multicentre study
    Stefano Bastianello
    Department of Public Health and Neurosciences, IRCCS C, Mondino National Institute of Neurology Foundation, University of Pavia, Italy
    BMC Neurol 11:132. 2011
    ..However, its actual prevalence, possible association with specific MS phenotypes, and potential pathophysiological role are debated...
  63. pmc Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
    David R Beers
    Department of Neurology, Methodist Neurological Institute, Suite ST 802, 6560 Fannin Street, Houston, TX 77030, USA
    Brain 134:1293-314. 2011
    ....
  64. ncbi The human centromeric survival motor neuron gene (SMN2) rescues embryonic lethality in Smn(-/-) mice and results in a mouse with spinal muscular atrophy
    U R Monani
    Departments of Neurology, College of Medicine, Ohio State University, Columbus, OH 43210, USA
    Hum Mol Genet 9:333-9. 2000
    ..These results show that SMA is caused by insufficient SMN production by the SMN2 gene and that increased expression of the SMN2 gene may provide a strategy for treating SMA patients...
  65. pmc Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
    Brian J Cummings
    Department of Physical Medicine and Rehabilitation, Reeve Irvine Research Center, University of California, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 102:14069-74. 2005
    ..migrate, and express differentiation markers for neurons and oligodendrocytes after long-term engraftment in spinal cord-injured NOD-scid mice...
  66. pmc JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain
    Yong Jing Gao
    Pain Research Center, Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 29:4096-108. 2009
    ..Spinal injection of TNF-alpha produced JNK-dependent pain hypersensitivity and MCP-1 upregulation in the spinal cord. Furthermore, spinal nerve ligation (SNL) induced persistent neuropathic pain and MCP-1 upregulation in the ..
  67. pmc NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration
    Shin H Kang
    The Solomon H Snyder Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21205, USA
    Neuron 68:668-81. 2010
    ..In regions of neurodegeneration in the spinal cord of ALS mice, NG2+ cells exhibited enhanced proliferation and accelerated differentiation into oligodendrocytes ..
  68. doi CCL2 released from neuronal synaptic vesicles in the spinal cord is a major mediator of local inflammation and pain after peripheral nerve injury
    Juliette Van Steenwinckel
    PAIN Group, Centre de Recherche de l Institut du Cerveau et de la Moelle Epiniere, Universite Pierre et Marie Curie, Inserm Unité Mixte de Recherche en Santé 975, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7225, 75013 Paris, France
    J Neurosci 31:5865-75. 2011
    ..tested the hypothesis that injury to peripheral nerves triggers CCL2 release from afferents in the dorsal horn spinal cord (DHSC), leading to pronociceptive effects, involving the production of proinflammatory factors, in particular...
  69. ncbi Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing
    Camilla I Svensson
    Department of Anesthesiology, University of California, San Diego, La Jolla, California, USA
    J Neurochem 86:1534-44. 2003
    ..in models of nociception and correlated this effect with localization and expression levels of p38 MAPK in spinal cord. There was a rapid increase in phosphorylated p38 MAPK in spinal cord following intrathecal administration of ..
  70. doi Transcriptional mechanisms controlling motor neuron diversity and connectivity
    Simon A Dalla Torre di Sanguinetto
    Biozentrum, Department of Cell Biology, University of Basel, Basel, Switzerland
    Curr Opin Neurobiol 18:36-43. 2008
    ..MN differentiation and connectivity, defining a sophisticated roadmap of motor circuit assembly in the spinal cord. Similar principles using modular interaction of transcriptional programs to control neuronal diversification ..
  71. doi A pericyte origin of spinal cord scar tissue
    Christian Goritz
    Department of Cell and Molecular Biology, Karolinska Institute, Stockholm, Sweden
    Science 333:238-42. 2011
    ..specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue...
  72. ncbi Dynamic sensorimotor interactions in locomotion
    Serge Rossignol
    Department of Physiology, Centre for Research in Neurological Sciences, Faculty of Medicine, Universite de Montreal, PO Box 6128, Station Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Physiol Rev 86:89-154. 2006
    ..Together these mechanisms contribute to the continuous dynamic adjustment of sensorimotor interactions, ensuring that the central program and feedback mechanisms are congruous during locomotion...
  73. pmc Loss of inhibitory interneurons in the dorsal spinal cord and elevated itch in Bhlhb5 mutant mice
    Sarah E Ross
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 65:886-98. 2010
    ..the atonal-related transcription factor Bhlhb5 is transiently expressed in the dorsal horn of the developing spinal cord and appears to play a role in the formation and regulation of pruritic (itch) circuits...
  74. ncbi Anti-aquaporin-4 antibody is involved in the pathogenesis of NMO: a study on antibody titre
    Toshiyuki Takahashi
    Department of Neurology, Tohoku University Graduate School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai 980 8574, Japan
    Brain 130:1235-43. 2007
    ..The lengths of spinal cord lesions on MRI were positively correlated with the titres of anti-AQP4 antibody at the nadir of exacerbations...
  75. pmc Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury
    Weiguo Peng
    Department of Neurosurgery, Division of Glial Disease and Therapeutics, Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 106:12489-93. 2009
    Traumatic spinal cord injury is characterized by an immediate, irreversible loss of tissue at the lesion site, as well as a secondary expansion of tissue damage over time...
  76. pmc Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
    David S Howland
    Department of Molecular Genetics, Wyeth Research, CN8000, Princeton, NJ 08543, USA
    Proc Natl Acad Sci U S A 99:1604-9. 2002
    ..rats depended on high levels of mutant SOD1 expression, increasing from 8-fold over endogenous SOD1 in the spinal cord of young presymptomatic rats to 16-fold in end-stage animals...
  77. ncbi Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 61:427-34. 2007
    ..We recently identified TDP-43 as the major pathological protein in sporadic ALS. In this study, we investigated TDP-43 in a larger series of ALS cases (n = 111), including familial cases with and without SOD1 mutations...
  78. doi Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice
    Mehdi Hossaini
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 70:662-77. 2011
    ..The degeneration of spinal inhibitory interneurons may in turn facilitate degeneration of motor neurons and contribute to disease progression...
  79. ncbi Brain abnormalities in neuromyelitis optica
    Sean J Pittock
    Department of Neurology, Laboratory Medicine and Pathology, Radiology, and Immunology, Mayo Clinic College of Medicine, Rochester, Minn, USA
    Arch Neurol 63:390-6. 2006
    ..a severe demyelinating disease defined principally by its tendency to selectively affect optic nerves and the spinal cord causing recurrent attacks of blindness and paralysis...
  80. doi Hox repertoires for motor neuron diversity and connectivity gated by a single accessory factor, FoxP1
    Jeremy S Dasen
    Smilow Neuroscience Program, Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016, USA
    Cell 134:304-16. 2008
    ..Our findings show that FoxP1 is a crucial determinant of motor neuron diversification and connectivity, and clarify how this Hox regulatory network controls the formation of a topographic neural map...
  81. doi Blocking EphB1 receptor forward signaling in spinal cord relieves bone cancer pain and rescues analgesic effect of morphine treatment in rodents
    Su Liu
    Department of Neurobiology, Parker University Research Institute, Dallas, Texas 75229, USA
    Cancer Res 71:4392-402. 2011
    ..Here, we report that EphB1 receptor forward signaling in the spinal cord is critical to the development of bone cancer pain and morphine tolerance in treating bone cancer pain...
  82. doi The blood-spinal cord barrier: morphology and clinical implications
    Viktor Bartanusz
    Department of Neurosurgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Ann Neurol 70:194-206. 2011
    The blood-spinal cord barrier (BSCB) is the functional equivalent of the blood-brain barrier (BBB) in the sense of providing a specialized microenvironment for the cellular constituents of the spinal cord...
  83. pmc VGLUT2-dependent glutamate release from nociceptors is required to sense pain and suppress itch
    Yang Liu
    Dana Farber Cancer Institute and Department of Neurobiology, Harvard Medical School, 1 Jimmy Fund Way, Boston, MA 02115, USA
    Neuron 68:543-56. 2010
    ..Our studies suggest that synaptic glutamate release from a group of peripheral nociceptors is required to sense pain and suppress itch. Elimination of VGLUT2 in these nociceptors creates a mouse model of chronic neurogenic itch...
  84. ncbi Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    Brian K Kaspar
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 301:839-42. 2003
    ..that adeno-associated virus can be retrogradely transported efficiently from muscle to motor neurons of the spinal cord. We report that insulin-like growth factor 1 prolongs life and delays disease progression, even when delivered ..
  85. pmc MicroRNAs are essential for the developmental switch from neurogenesis to gliogenesis in the developing spinal cord
    Kang Zheng
    College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, Zhejiang 310036, China
    J Neurosci 30:8245-50. 2010
    ..By contrast, the early patterning and development of motor neurons were not affected in the mutant spinal cord tissue.
  86. doi A neural basis for motor primitives in the spinal cord
    Corey B Hart
    Neurobiology and Anatomy, College of Medicine and School of Bioengineering and Health Sciences, Drexel University, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 30:1322-36. 2010
    ..To investigate this, we recorded 302 neurons, making multielectrode recordings in the spinal cord gray of spinalized frogs, at 400, 800, and 1200 mum depth, at the L2/L3 segment border...
  87. ncbi Neuropilin-semaphorin III/D-mediated chemorepulsive signals play a crucial role in peripheral nerve projection in mice
    T Kitsukawa
    Division of Biological Science, Nagoya University Graduate School of Science, Japan
    Neuron 19:995-1005. 1997
    ..Our results indicate that neuropilin-semaphorin III/D-mediated chemorepulsive signals play a major role in guidance of PNS efferents...
  88. ncbi Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord
    P J Horner
    The Salk Institute for Biological Studies, Laboratory of Genetics, La Jolla, California 92037, USA
    J Neurosci 20:2218-28. 2000
    ..To extend this knowledge to the adult spinal cord we have examined the proliferation, distribution, and phenotypic fate of dividing cells in the adult rat spinal ..
  89. ncbi Locomotor activity in spinal cord-injured persons
    V Dietz
    Spinal Chord Injury Center, University Hospital Balgrist, 8008 Zurich, Switzerland
    J Appl Physiol (1985) 96:1954-60. 2004
    After a spinal cord injury (SCI) of the cat or rat, neuronal centers below the level of lesion exhibit plasticity that can be exploited by specific training paradigms...
  90. pmc Early motor neuron pool identity and muscle nerve trajectory defined by postmitotic restrictions in Nkx6.1 activity
    Natalia V De Marco Garcia
    Howard Hughes Medical Institute, Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:217-31. 2008
    ..Our findings provide genetic evidence that neurons within motor pools possess an early transcriptional identity that controls target muscle specificity...
  91. pmc Neurog2 is a direct downstream target of the Ptf1a-Rbpj transcription complex in dorsal spinal cord
    R Michael Henke
    Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Development 136:2945-54. 2009
    ..and glutamatergic interneurons in multiple regions of the nervous system, including the dorsal horn of the spinal cord and the cerebellum...
  92. pmc IL-10 promotes neuronal survival following spinal cord injury
    Zhigang Zhou
    Department of Neurology, University of Michigan and Ann Arbor VA Healthcare System, 5027 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Exp Neurol 220:183-90. 2009
    ..that the anti-inflammatory cytokine IL-10 induces a number of signaling cascades through the IL-10 receptor in spinal cord neurons in vitro to activate NF-kappaB transcription Bcl-2 and Bcl-x(L) and that, after exposure to glutamate ..
  93. pmc Two-photon laser scanning microscopy imaging of intact spinal cord and cerebral cortex reveals requirement for CXCR6 and neuroinflammation in immune cell infiltration of cortical injury sites
    Jiyun V Kim
    Helen L and Martin S Kimmel Center for Biology and Medicine of the Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    J Immunol Methods 352:89-100. 2010
    The mouse spinal cord is an important site for autoimmune and injury models. Skull thinning surgery provides a minimally invasive window for microscopy of the mouse cerebral cortex, but there are no parallel methods for the spinal cord...
  94. pmc Evidence that intrathecal morphine-3-glucuronide may cause pain enhancement via toll-like receptor 4/MD-2 and interleukin-1beta
    S S Lewis
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Neuroscience 165:569-83. 2010
    ..a novel mechanism for M3G-mediated pain enhancement, as (a) TLR4 is predominantly expressed by microglia in spinal cord and (b) TLR4 activation releases pain-enhancing substances, including interleukin-1 (IL-1)...
  95. doi Spinal cord mechanisms of pain
    R D'Mello
    Department of Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    Br J Anaesth 101:8-16. 2008
    The spinal cord is the first relay site in the transmission of nociceptive information from the periphery to the brain...
  96. ncbi Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
    J D Rothstein
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21205
    N Engl J Med 326:1464-8. 1992
    ..chronic degenerative neurologic disorder characterized by the death of motor neurons in the cerebral cortex and spinal cord. Recent studies have suggested that the metabolism of glutamate, a potentially neurotoxic amino acid, is ..
  97. ncbi Spinal cord stimulation versus conventional medical management for neuropathic pain: a multicentre randomised controlled trial in patients with failed back surgery syndrome
    Krishna Kumar
    Department of Neurosurgery, Regina General Hospital, 1440 14th Avenue, Regina, Sask, Canada
    Pain 132:179-88. 2007
    ..We hypothesised that spinal cord stimulation (SCS) is an effective therapy in addition to conventional medical management (CMM) in this patient ..
  98. pmc Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons
    David L Rousso
    Department of Neurobiology, Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Neuron 59:226-40. 2008
    ..of Foxp1 act in accordance with the rostrocaudal pattern provided by Hox proteins along the length of the spinal cord, suggesting a model by which motor neuron diversity is achieved through the coordinated actions of Foxp1 and ..
  99. ncbi Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling
    J Ericson
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York 10032, USA
    Cell 90:169-80. 1997
    ..2. Pax6 establishes distinct ventral progenitor cell populations and controls the identity of motor neurons and ventral interneurons, mediating graded Shh signaling in the ventral spinal cord and hindbrain.
  100. ncbi A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification
    Bennett G Novitch
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, 701 West 168th Street, New York, NY 10032, USA
    Neuron 40:81-95. 2003
    The specification of neuronal fates in the ventral spinal cord depends on the regulation of homeodomain (HD) and basic-helix-loop-helix (bHLH) proteins by Sonic hedgehog (Shh)...
  101. ncbi In vivo imaging of axonal degeneration and regeneration in the injured spinal cord
    Martin Kerschensteiner
    Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, Massachusetts 02138, USA
    Nat Med 11:572-7. 2005
    The poor response of central axons to transection underlies the bleak prognosis following spinal cord injury...

Research Grants84

  1. NIH Director's Pioneer Award
    ERICH JARVIS; Fiscal Year: 2009
    ..Repairing the pathway in vocal learners, when damaged, would have profound impact for correcting neurological disorders of speech. ..
  2. Yasmin Wadia; Fiscal Year: 2014
    ..are sealing of solid visceral organs (liver, kidney, pancreas and spleen) involved in polytrauma, and neoplasms;spinal cord and nerve reattachment;sterilization of contaminated wounds, sealing of dural, esophageal and duodenal ..
  3. Transcription factors regulating sensory gene expression and pain pathways
    Eric E Turner; Fiscal Year: 2011
    ..Islet1 are required for pain receptor neurons to correctly connect to their targets in the skin, muscles and spinal cord. The genes regulated by Brn3a and Islet1 are a catalogue of neurotransmitters, receptors and channels already ..
  4. Ashraf Gorgey; Fiscal Year: 2016
    DESCRIPTION Individuals with spinal cord injury (SCI) are at a lifelong risk of increasing obesity and several chronic metabolic disorders such as glucose intolerance, insulin resistance and dyslipidemia secondary to deterioration in ..
  5. Patrice G Guyenet; Fiscal Year: 2015
    ..of this network consists of modified catecholaminergic neurons called the C1 neurons that innervate the spinal cord and regulate sympathetic tone to the heart and blood vessels...
  6. ANTHONY JOHN KANAI; Fiscal Year: 2016
    ..optical mapping of UC, dorsal root ganglia (DRG) neurons and afferent nerve terminals in the bladder wall and spinal cord. Cells and tissues will be stained with voltage- or Ca2+-sensitive dyes and/or afferent nerves labeled using ..
  7. ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2014
    ..In FRDA, the cerebellar dentate nuclei and the dorsal root ganglia (DRG) of the spinal cord are highly vulnerable...
  8. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..that TRPV1 mediates pancreatic inflammatory pain via the release of neuropeptides both in the pancreas and spinal cord, whether the newer ion channels TRPV4 and TRPA1 participate in pancreatic inflammation and pain is unknown...
  9. Glutamate receptor recruitment to new synapses in vivo
    PHILIP ERIC WASHBOURNE; Fiscal Year: 2013
    ..for our experiments including cultured hippocampal neurons, cultured cerebellar granule cells (CGCs) and spinal cord neurons in zebrafish embryos in vivo...
  10. Cellular and Animal Models of FUS Mutations in ALS
    Eric J Huang; Fiscal Year: 2013
    ..the mutant FUS proteins in the development and maintenance of synaptic connectivity of motor neurons within the spinal cord and at the neuromuscular junction (NMJ). We propose two specific aims to achieve these goals...
  11. Mechanims of CNS Autonomic Regulation by EA
    John C Longhurst; Fiscal Year: 2013
    ..EA segmental regulation of elevated blood pressure through actions involving dynorphin and nociceptin in the spinal cord dorsal horn and intermediolateral columns...
  12. Kenneth L Tyler; Fiscal Year: 2015
    ..nervous system (CNS) by either killing or disrupting essential functions of neurons within the brain and spinal cord. We propose to use well characterized models of virus-induced CNS disease to investigate the mechanisms by ..
  13. Kenneth J Gustafson; Fiscal Year: 2015
    ..provided by applicant): Objectives and Research Aims: Neurogenic bladder resulting from disorders such as spinal cord injury (SCI) can have a devastating impact on patients and their families, resulting in a high cost to the ..
  14. BEATRICE JENNY KIRATLI; Fiscal Year: 2014
    ..of rehabilitation exercise and to evaluate its potential for positive therapeutic outcomes in individuals with spinal cord injury (SCI)...
  15. C. Difficile Outcomes and Effectiveness of Treatment Strategies in SCI
    Charlesnika T Evans; Fiscal Year: 2013
    ..morbidity, mortality, and utilization associated with Clostridium difficile infection (CDI) in veterans with spinal cord injury and disorder (SCI/D)...
  16. Role of Potent Trophic Factors on Glia and Motor Neurons in ALS
    Brian K Kaspar; Fiscal Year: 2013
    ..in an in vivo AAV (Adeno-Associated Virus) gene delivery paradigm that efficiently targets all regions of the spinal cord. We will analyze the mechanism by which these trophic factors mediate their effects on astrocytes and finally, ..
  17. Jingsong Zhou; Fiscal Year: 2014
    ..Disease," is a progressive neuromuscular disorder that involves loss of nerve cells in the brain and the spinal cord, and atrophy of skeletal muscle...
  18. Na+/H+-exchanger-1 and Diabetic Neuropathy
    MARK ANTHONY YOREK; Fiscal Year: 2012
    ..3) evaluate the contribution of NHE-1 to oxidative-nitrosative stress in peripheral nerve, vasa nervorum, spinal cord, and DRG neurons of diabetic rats and high glucose-exposed cultured HSC and co-cultured rat SC and DRG neurons...
  19. Mechanisms Regulating Reduced c-Kit-Dependent EAE Susceptibility in Male SJL Mice
    MELISSA ANN BROWN; Fiscal Year: 2013
    ..resulting interruption of motor and sensory impulses as they pass through demyelinated regions of the brain or spinal cord often leads to visual disturbances, incontinence as well as sensory and motor disturbances...
  20. Optical Molecular Tomography for Regenerative Medicine
    Ge Wang; Fiscal Year: 2013
    ..stroke, degenerative neurological diseases, diabetes, arthritis, osteoporosis, kidney and liver failure, spinal cord injury, burns, battlefield trauma, and other devastating conditions...
  21. Novel Collagen II Alternative Transcripts and Mouse Skeletal Development
    Audrey McAlinden; Fiscal Year: 2010
    ..in a number of embryonic non-cartilage tissues such as the notochord, somitic mesoderm, fetal brain, spinal cord, developing eye, tendons and ligaments...
  22. April N Herrity; Fiscal Year: 2014
    ..provided by applicant): Secondary health complications present a major concern for people living with spinal cord injury (SCI)...
  23. Enhance Production of Functional Recombinant Human Protein C Variant In Mammalian
    Nienwen Chow; Fiscal Year: 2010
    ..In SOD1 mutants of different biochemical characteristics, we have shown endothelial degeneration in the spinal cord, microhemorrhages and blood-spinal cord barrier (BSCB) disruption before motor neuron degeneration...
  24. Kim Wallen; Fiscal Year: 2014
    ..estrogens, including decreased sexual motivation, hot flushes, sleep disorders, depression/anxiety, brain and spinal cord trauma, amyotrophic lateral sclerosis, and cognitive dysfunction...
  25. Potentiation of Glycine Receptors by Ethanol
    LUIS GERARDO AGUAYO; Fiscal Year: 2010
    Activation of glycine receptors (GlyRs) in brain stem, spinal cord and brain provides a main inhibitory control for neuronal excitability...
  26. Pharmacological strategies to improve breathing after cervical spinal cord injury
    FRANCIS GOLDER; Fiscal Year: 2009
    Respiratory failure is the leading cause of morbidity and mortality in people with acute and chronic cervical spinal cord injury (SCI)...
  27. Scott R Barnum; Fiscal Year: 2014
    ..is a progressive motor neuron disease that leads to degeneration of motor neurons in the cortex, brainstem and spinal cord resulting in progressive paralysis and ultimately death...
  28. High affinity capturing agents for strychnine
    Kit S Lam; Fiscal Year: 2011
    ..Strychnine is a potent antagonist for the inhibitory glycine receptor, a ligand-gated chloride channel in the spinal cord and the brain. It can cause muscular convulsions and eventually death through asphyxia and exhaustion...
  29. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..direct intercellular ionic, electrical, and metabolic coupling between nerve cells in the brain, retina, and spinal cord. Previously, gap junctions between neurons were thought to consist of hundreds or thousands of connecting ..
  30. Optimization of EphA4 antagonists for CNS disorders
    ELENA B contact PASQUALE; Fiscal Year: 2010
    ..with this, recent studies suggest that inhibiting EphA4-ephrin interaction could be useful for the treatment of spinal cord injuries...
  31. WADE HAMPTON MARTIN; Fiscal Year: 2014
    ..of lower extremity disabilities such as amputations, knee or other arthropathies, myopathies, claudication, spinal cord, or combat injuries...
  32. Pathophysiology and Animal Model of Restless Legs Syndrome (RLS): Btbd9 Null Mic
    Yuqing Li; Fiscal Year: 2010
    ..apparatus and examine the morphology and number of A11 neurons in hypothalamus that are known to project to spinal cord. Levels of tissue dopamine, their metabolites, and dopamine receptors will also be determined in striatum. 2...
  33. ALEXANDER VLADIMIROVICH OVECHKIN; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): Many individuals with chronic spinal cord injury (SCI) face the challenge of managing their unstable blood pressure which frequently results in persistent hypotension due to decreased cardiac output ..
  34. Innate Immune Mechanisms of Motor Neuron Injury
    Timothy Vartanian; Fiscal Year: 2010
    ..By contrast, activation of TLR3 results in selective loss of motor neurons in primary dissociated spinal cord cultures...
  35. Functional Bowel Disorders in Chinese Medicine
    Brian Berman; Fiscal Year: 2009
    ..3. To determine the effect of EA on serotoninergic activites at spinal cord level in rats with visceral hyperalgesia. 4...
  36. Food(cassava) cyanogen exposure and motor neuron degeneration
    DANIEL DESIRE TSHALA KATUMBAY; Fiscal Year: 2010
    ..characterize the neuropathology, and assess changes in selected indicators of protein misfolding in brain/spinal cord tissues of young Wistar rats kept on SAA-deficient diets and treated with linamarin, NaOCN (positive control) ..
  37. Diagnostic array for aseptic encephalitis
    Darrell P Chandler; Fiscal Year: 2011
    ..fatal diseases defined by acute swelling of the brain or protective membranes covering the brain and spinal cord. These diseases can be caused by viruses, bacteria, fungi and parasites...
  38. Abidemi Bolu Ajiboye; Fiscal Year: 2015
    ..stereotyped patterns of electrical activation to peripheral nerves to achieve movement restoration in spinal cord injured (SCI) persons...
  39. Onanong Chivatakarn; Fiscal Year: 2014
    ..In vertebrates, MNs develop in the ventral spinal cord and hindbrain, their cell bodies migrate to specific positions along the medio-lateral and dorso-ventral axes ..
  40. The Transcobalamin Receptor in Cobalamin Homeostasis
    Edward V Quadros; Fiscal Year: 2011
    ..The neurological disorders result from demyelinating changes in the peripheral nerves, the spinal cord and changes yet to be defined in the brain...
  41. Effects of nerve demyelination on auditory synaptic functions
    Jun Hee Kim; Fiscal Year: 2012
    ..Most studies related to demyelination have focused on the PNS and spinal cord axons, however, little is known about how loss of myelin sheaths affects the synaptic transmission at the ..
  42. Gross Hall Animal Resource Center
    Susan V Bryant; Fiscal Year: 2010
    ..other metabolic disorders, immunology, macular degeneration, retinitis pigmentosa, herpes-related blindness, spinal cord injury, and stroke...
  43. TRANSCRIPTION FACTORS IN CONTROL OF BRAIN DEVELOPMENT
    Eric E Turner; Fiscal Year: 2010
    ..primary sensory neurons at all axial levels and in selected neurons of the retina, diencephalon, brainstem and spinal cord. Targeted disruption of Brn3a in mice results in loss of neurons in the sensory ganglia and some CNS nuclei, ..
  44. Kamal A Mohammed; Fiscal Year: 2014
    ..infections are a major and growing cause of hospital-associated pneumonia in patients with trauma, surgery and spinal cord injury...
  45. Warren G Hill; Fiscal Year: 2014
    ..PUBLIC HEALTH RELEVANCE: There are large numbers of people who for many different reasons - spinal cord injury, diabetes, cystitis - suffer from disorders of the bladder which can broadly be characterized as ..
  46. Astrocytes Play a Critical Role in the Pathology of EAE
    JOHN ROLAND BETHEA; Fiscal Year: 2013
    ..Studies in this aim will focus on how inhibiting astroglial NF-kB alters T and B cell responses in the spinal cord. Finally, since demyelination is a hallmark of this disease and could be modulated by neuroinflammation, ..
  47. Noncoding RNA targets of the spinal muscular atrophy protein
    Livio Pellizzoni; Fiscal Year: 2010
    SMA is an autosomal recessive disorder characterized by degeneration of motor neurons in the spinal cord and skeletal muscle atrophy...
  48. Targeted investigation of tissue specific oxidative stress in the etiology of ALS
    Holly Van Remmen; Fiscal Year: 2013
    ..damage to lipid (F2-isoprostanes, neuroprostanes), DNA (oxo8dG) and protein (carbonyls, HNE adducts) in spinal cord and gastrocnemius muscle at pre-symptomatic, onset and end stages of the disease to determine the impact of ..
  49. PROTEIN CARBONYLATION AND AXONAL DAMAGE IN EAE
    Oscar A Bizzozero; Fiscal Year: 2012
    ..To test our hypothesis, we will measure the levels of protein carbonyls in the spinal cord and brain of remitting/relapsing EAE mice in relationship to well-established pathological hallmarks of the ..
  50. SEX EFFECTS ON CHEMOKINE MEDIATED CNS AUTOIMMUNITY
    Lillian Cruz-Orengo; Fiscal Year: 2012
    ..Our lab, has found that normal human brain and mouse spinal cord tissues exhibit ablumenal localization of the chemokine CXCL12 at their vasculature...
  51. Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis
    Martin Steinhoff; Fiscal Year: 2013
    ..hypothesize that IL-31 and OSM alone and/or in combination, activate subsets of dorsal root ganglion (DRG) and spinal cord (SC) neurons and keratinocytes through their receptors, thereby regulating neurogenic inflammation, pruritus ..
  52. Victor L Arvanian; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Many soldiers return home with contusive spinal cord injuries (SCI), mostly due to the powerful explosives used in the improvised bombs that rattle U.S. troops inside heavily armored vehicles...
  53. Development of CNS-targeted AAV vectors
    MIGUEL S ESTEVES; Fiscal Year: 2012
    ..of 5x109 clones generated by DNA shuffling of AAV1, 2, 5, 8, 9, and rh10 Cap genes, to identify new brain- and spinal cord-tropic AAV capsids after intravenous or ICV delivery in adult animals...
  54. DANIEL S MUCIDA; Fiscal Year: 2014
    ..lymphoid organ in the body, the digestive tract is recognized as "a second brain", with as many neurons as the spinal cord. The enteric nervous system (ENS) is organized in several plexuses throughout the intestinal wall...
  55. STEVEN SIMON SCHERER; Fiscal Year: 2016
    ..connexins (Cx30, Cx32, Cx43, Cx47) in two tracts - the optic nerve and the ventral funiculus of the cervical spinal cord. 3. The functional significance of O: O coupling. The function of O: A and O: O coupling is uncertain...
  56. Neurorestorative Strategy for Diabetic Peripheral Neuropathy
    Feng Qiao Li; Fiscal Year: 2013
    ..has been validated in animal models of a variety of neurological disorders such as traumatic brain injury, spinal cord injury, subarachnoid hemorrhage and multiple sclerosis, implicating a therapeutic efficacy for these diseases...
  57. Small Oligonucleotides As Therapeutic Agents Of Spinal Muscular Atrophy
    Ravindra N Singh; Fiscal Year: 2012
    ..corrects SMN2 exon 7 splicing and raise the levels of full-length SMN in all tissues including brain and spinal cord of mice models of SMA. In Aim 1, we will optimize our short ASO for application in vivo...
  58. Rudi Kobetic; Fiscal Year: 2015
    ..speed to improve ambulatory community access of persons with lower extremity paralysis due to incomplete spinal cord injury (ISCI)...
  59. Slobodan M Todorovic; Fiscal Year: 2014
    ..in supporting spontaneous excitatory synaptic transmission in nociceptive neurons of superficial lamina of the spinal cord dorsal horn (DH)...
  60. Genetic Mapping Of Novel Molecular Players in Itch
    RACHEL BETH BREM; Fiscal Year: 2013
    ..genes and biomolecules that underlie itch, focusing on signaling mechanisms in primary afferent neurons and spinal cord modulatory interneurons...
  61. Spinal Cord-Mediated Acute Neurogenic Inflammation
    Qing Lin; Fiscal Year: 2010
    ....
  62. A Spontaneous Mouse Model of Motor Neuron Disease
    Kevin L Seburn; Fiscal Year: 2011
    ..and neuromuscular junctions indicate a motor neuron defect, and examination of motor neuron cell bodies in the spinal cord ventral horn reveals pathology including eosin-rich, ubiquitin-positive inclusions...
  63. Helene M Langevin; Fiscal Year: 2015
    ..tissue relaxation (ex vivo), markers of areolar PCT neurogenic inflammation (NGF, IL1-2 and TNF-1) and spinal cord Substance P and CGRP fiber density...
  64. Lori A Birder; Fiscal Year: 2014
    ..Moreover, we also have evidence of long-term alterations in FIC spinal cord glial cell morphology and function in regions of pelvic afferent input suggesting that these cells play a role ..
  65. ZeroG: Dynamic Over-Ground Body-Weight Support System
    Joseph Hidler; Fiscal Year: 2009
    ..In the acute stages of many neurological injuries such as stroke, spinal cord injury, or traumatic brain injury, individuals often exhibit highly unstable walking patterns and poor ..
  66. Evaluation of Wire Electrodes to Activate the Expiratory Muscles to Restore Cough
    Anthony F DiMarco; Fiscal Year: 2010
    ..Respiratory complications account for significant morbidity and mortality in patients with spinal cord injury due to their inability to cough and clear secretions...
  67. Acute Phase Treatment of Spinal Cord Injury Using Hydrogel Blends Loaded with Glu
    Ryan Gilbert; Fiscal Year: 2009
    The goal of this study is to develop new technology to reduce secondary injury following spinal cord injury. Currently, there are no viable treatments for patients who have sustained spinal cord injury...
  68. Novel Ex Vivo Gene Therapy for Spinal Cord Injury
    Alpa Trivedi; Fiscal Year: 2004
    There are approximately 10,000 traumatic spinal cord injuries in the United States each year. The average age of injury is 31 years. The majority (90%) of individuals survive and live near-normal life spans...
  69. Sensory Plasticity During Central Neuropathic Pain Caused by Spinal Cord Injury
    Edgar T Walters; Fiscal Year: 2010
    Description (provided by applicant): Summary Persistent neuropathic pain is produced by spinal cord injury (SCI) in a majority of patients...
  70. Heme Oxygenase and Spinal Cord Injury
    Linda Noble; Fiscal Year: 2004
    Functional recovery after spinal cord injury is attributed to secondary pathogenic events that mediate early and delayed cell injury...
  71. PEPTIDERGIC NEURONS IN THE SPINAL CORD
    VIRGINIA SEYBOLD; Fiscal Year: 1999
    DESCRIPTION: The overall goal of our research is to understand neurochemical mechanisms in the spinal cord that contribute to persistent hyperalgesia...
  72. Neuroprotective Drugs for Spinal Cord Injury
    JEAN WRATHALL; Fiscal Year: 2001
    DESCRIPTION: (Adapted from the Applicant's Abstract) Traumatic spinal cord injury (SCI) leads to permanent loss of motor function and control of function below the level of the injury...
  73. OXIDATION OF MACROMOLECULES IN SPINAL CORD INJURY
    Danxia Liu; Fiscal Year: 2001
    The long term objective of this project is to reveal mechanisms whereby free radicals damage neurons following spinal cord injury - a major health care issue...
  74. Novel Gene Delivery Development for Spinal Muscular Atrophy
    Brian Kaspar; Fiscal Year: 2009
    ..disorder characterized by the loss of lower motor neurons (LMNs) residing along the entire length of the spinal cord. SMA is caused by a reduction in the expression of the survival motor neuron (SMN) protein...
  75. GENE THERAPY FOR SPINAL CORD REGENERATION
    George Smith; Fiscal Year: 2006
    Neurons have the intrinsic ability to regenerate after injury to the adult mammalian spinal cord as demonstrated by transplantation of either peripheral nerves, Schwann cells, or fetal spinal cord tissue...
  76. Spinal cord injury: Targeting local inhibition to improve outcome
    Linda J Noble; Fiscal Year: 2010
    ..for a new therapeutic approach in a neurologic disease: 15-NS-104 It is estimated that 11,000 Americans suffer spinal cord injury (SCI) every year...
  77. Development of a high-throughput screen for inhibitors of water permeability thro
    Marc Pelletier; Fiscal Year: 2009
    Cerebral edema (and its counterpart in the spinal cord) is a major contributor to the damage caused by stroke, traumatic brain injury, traumatic spinal-cord injury, and bacterial meningitis...
  78. Spinal Cord Stimulation to Restore Cough In Humans
    Anthony DiMarco; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Patients with cervical and thoracic spinal cord injuries have paralysis of a major portion of their expiratory muscles and therefore, lack a normal cough mechanism...
  79. Matrix Metalloproteinases and Spinal Cord Injury
    Linda J Noble; Fiscal Year: 2010
    Recovery after spinal cord injury is in part attributed to secondary events that govern both detrimental and reparative processes...