- Retinoic acid from the meninges regulates cortical neuron generation
Julie A Siegenthaler
Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
Cell 139:597-609. 2009
..In this study we demonstrate that the dorsal forebrain meninges communicate with the adjacent radial glial endfeet and influence cortical development...
- Telocytes in meninges and choroid plexus
B O Popescu
Department of Neurology, University Hospital, Carol Davila Medical University, Bucharest, Romania
Neurosci Lett 516:265-9. 2012
..We report here identification of TCs by electron microscopy and immunofluorescence in rat meninges and choroid plexus/subventricular zone, in the vicinity of putative stem cells...
- Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE
Alison L Christy
Northwestern University, Feinberg School of Medicine, Department of Microbiology and Immunology, Chicago, IL, USA
J Autoimmun 42:50-61. 2013
The meninges are often considered inert tissues that house the CSF and provide protection for the brain and spinal cord. Yet emerging data demonstrates that they are also active sites of immune responses...
- Migraine pain, meningeal inflammation, and mast cells
Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E CLS639, Boston, MA 02215, USA
Curr Pain Headache Rep 13:237-40. 2009
..and the subsequent activation of trigeminal primary afferent nociceptive neurons that supply the intracranial meninges and their related large blood vessels...
- Regulation of learning and memory by meningeal immunity: a key role for IL-4
Noel C Derecki
Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
J Exp Med 207:1067-80. 2010
..Performance of cognitive tasks led to accumulation of IL-4-producing T cells in the meninges. Depletion of T cells from meningeal spaces skewed meningeal myeloid cells toward a proinflammatory phenotype...
- Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
Brain Pathol 14:164-74. 2004
..and plasma cells, and a network of follicular dendritic cells producing CXCL13 were observed in the cerebral meninges of 2 out of 3 patients with secondary progressive MS, but not in relapsing remitting and primary progressive MS...
- Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats
Liza Q Bundesen
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
J Neurosci 23:7789-800. 2003
..by reactive CNS astrocytes, and EphB2 is present on fibroblasts invading the lesion site from the adjacent meninges. During the first 3 d after injury, there is intermingling of ephrin-B2-expressing reactive astrocytes at the ..
- Retinoic acid synthesis for the developing telencephalon
Eunice Kennedy Shriver Center for Mental Retardation, Waltham, MA 02452, USA
Cereb Cortex 11:894-905. 2001
..Because of its diffusible character, retinoic acid represents a unique tool for the coordination of growth processes over an intermediate distance range in the developing telencephalon...
- The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates
Institut Cochin, Université Paris Descartes Faculté de Médecine, Centre National de la Recherche Scientifique UMR 8104, 75014 Paris, France
J Exp Med 207:2313-22. 2010
..In conclusion, HvgA is a critical virulence trait of GBS in the neonatal context and stands as a promising target for the development of novel diagnostic and antibacterial strategies...
- Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy
Paul G McMenamin
School of Anatomy and Human Biology, University of Western Australia, 35 Stirling Highway, 6009 Crawley, Perth, Western Australia, Australia
Cell Tissue Res 313:259-69. 2003
..provides novel information on the topographical distribution of macrophages and dendritic cells (DCs) in normal meninges and choroid plexus of the rat central nervous system (CNS)...
- Microscopic morphology and histology of the human meninges
R O Weller
Clinical Neurosciences, Southampton University School of Medicine, Mail Point 813, Southampton General Hospital, Southampton SO16 6YD, UK
Morphologie 89:22-34. 2005
The meninges comprise the dura mater and the leptomeninges (arachnoid and pia mater). Dura forms an outer endosteal layer related to the bones of the skull and spine and an inner layer closely applied to the arachnoid mater...
- Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction
Department of Public Health and Community Medicine, Section of Pharmacology, University of Verona, Verona, Italy
Stem Cells 29:2062-76. 2011
..In this study, we describe a new population of cells resident in the adult rat spinal cord meninges that express the neural stem/precursor markers nestin and doublecortin...
- Deciphering the contribution of human meningothelial cells to the inflammatory and antimicrobial response at the meninges
Pierre Joseph Royer
School of Molecular Medical Sciences and School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
Infect Immun 81:4299-310. 2013
..It also sheds light on the complexity of intracellular signaling after TLR triggering. ..
- Grey matter pathology in multiple sclerosis
Jeroen J G Geurts
Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands
Lancet Neurol 7:841-51. 2008
..These hypotheses remain to be validated over the coming years, and could substantially affect our current views on MS pathogenesis...
- Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the meninges and the choroid plexus: implications for non-neuronal sources for GABA in the developing mouse brain
Department of Anatomy and Developmental Neurobiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
PLoS ONE 8:e56901. 2013
..Recent studies revealed that the meninges and the cerebrospinal fluid have certain roles to regulate brain development...
- Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts
Katherine A Zukor
Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84132, USA
Neural Dev 6:1. 2011
- Lagochilascariasis leading to severe involvement of ocular globes, ears and meninges
Renata T R Aquino
Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP, Brasil
Rev Inst Med Trop Sao Paulo 50:355-8. 2008
..woman from Paraíba State (North-Eastern Brazil) that presented severe involvement of ocular globes, ears and meninges. Diagnosis was established after enucleation of her left eye, when adult worms were seen in the midst of a ..
- hebp3, a novel member of the heme-binding protein gene family, is expressed in the medaka meninges with higher abundance in females due to a direct stimulating action of ovarian estrogens
Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo 113 8657, Japan
Endocrinology 154:920-30. 2013
..The medaka hebp3 is expressed in the meninges with higher abundance in females, whereas there is no expression within the brain parenchyma...
- Central origin of IL-1beta produced during peripheral inflammation: role of meninges
B V Garabedian
Laboratoire Développement et Vieillissement du Système Nerveux DVSN, Institut des Neurosciences, CNRS UMR 7624, Universite Pierre et Marie Curie, 9 quai Saint Bernard, 75005, Paris, France
Brain Res Mol Brain Res 75:259-63. 2000
..We measured IL-1beta mRNA in the cerebellum, hippocampus and cerebral cortex collected with meninges and in the same structures collected without meninges after a peripheral lipopolysaccharide (LPS) stimulation (0...
- Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature
US Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
Synapse 63:881-94. 2009
..Rats were sacrificed either 3 h or 1 day after dosing, and total RNA and protein was isolated from the meninges, arachnoid and pia membranes, and associated vasculature (MAV) that surround the forebrain...
- Developmental changes of mast cell populations in the cerebral meninges of the rat
Laboratory of Anatomy and Histology, Veterinary School, Aristotle University of Thessaloniki, Greece
J Anat 211:556-66. 2007
..The present study shows that unevenly distributed mast cells in the cerebral meninges of the rat can be found in perivascular sites and vessel ramification points, but can also be unrelated to the ..
- Inflammatory myofibroblastic tumor of the orbit with associated enhancement of the meninges and multiple cranial nerves
A M McKinney
Department of Radiology, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis 55415, USA
AJNR Am J Neuroradiol 27:2217-20. 2006
- Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges
Mark I Fowler
Molecular Microbiology and Infection, Division of Infection, Inflammation and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, UK
Cell Microbiol 6:555-67. 2004
- Spontaneous locomotor activity correlates with the degranulation of mast cells in the meninges rather than in the thalamus: disruptive effect of cocaine
Alice A Larson
Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Avenue, Room 295, St Paul, MN 55108, USA
Brain Res 1395:30-7. 2011
..of cocaine on circulating corticosterone, motor activity and degranulation of mast cells in both the thalamus and meninges of mice...
- The effects of subarachnoid administration of preservative-free S(+)-ketamine on spinal cord and meninges in dogs
Alfredo Cury Rojas
Anesthesiology Department, Sao Paulo State University, Botucatu SP, Brazil
Anesth Analg 114:450-5. 2012
..In this study we evaluated the effects of a single dose of preservative-free S(+)-ketamine, in doses usually used in clinical practice, in the spinal cord and meninges of dogs.
- Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations
P G McMenamin
Department of Anatomy and Human Biology, University of Western Australia, Nedlands
J Comp Neurol 405:553-62. 1999
..Until now it has been assumed DC are largely absent from the brain, meninges, and the choroid plexus within the ventricles...
- Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly
Laboratory for Comparative Neurogenesis Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
J Neurosci 28:4712-25. 2008
..These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly...
- Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures
Institute of Human Physiology, University of Ancona, Italy
J Comp Neurol 409:482-94. 1999
..The widespread cellular expression of GAT-2 suggests that it may have several functional roles in the overall regulation of GABA levels in the brain...
- Innate response to focal necrotic injury inside the blood-brain barrier
Jiyun V Kim
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
J Immunol 177:5269-77. 2006
..Necrotic injury in the meninges, but not the brain parenchyma, recruited GFP+ cells within minutes that fully surrounded the necrotic site within ..
- Differential gene expression during meningeal-meningococcal interaction: evidence for self-defense and early release of cytokines and chemokines
D B Wells
Molecular Bacteriology and Immunology Group, Divisions of Microbiology and Infectious Diseases, University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom
Infect Immun 69:2718-22. 2001
..Also, a trend in up-regulation of anti-apoptotic genes and down-regulation of pro-apoptotic genes was observed. This is the first evidence that meningothelial cells may mount cytoprotective responses to pathogenic bacteria...
- Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis
Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA
Brain 134:534-41. 2011
In the central nervous system of patients with multiple sclerosis, B cell aggregates populate the meninges, raising the central question as to whether these structures relate to the B cell infiltrates found in parenchymal lesions or ..
- Group B Streptococcus surface proteins as major determinants for meningeal tropism
Institut Cochin, Université Paris Descartes Sorbonne Paris Cité, CNRS UMR 8104, Paris, France
Curr Opin Microbiol 15:44-9. 2012
- We have got you 'covered': how the meninges control brain development
Julie A Siegenthaler
Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA 94158, United States
Curr Opin Genet Dev 21:249-55. 2011
The meninges have traditionally been viewed as specialized membranes surrounding and protecting the adult brain from injury. However, there is increasing evidence that the fetal meninges play important roles during brain development...
- Comparison of the inflammatory responses of human meningeal cells following challenge with Neisseria lactamica and with Neisseria meningitidis
Mark I Fowler
Molecular Microbiology Group, Division of Infection, Inflammation and Repair, Mailpoint 814, University of Southampton Medical School, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
Infect Immun 74:6467-78. 2006
..for the present study was to determine how different species of bacteria interact with cells of the human meninges in order to gain information that would have broad relevance to understanding aspects of the innate immune ..
- Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
J Exp Med 208:1695-705. 2011
..receptor tyrosine kinase 3)-dependent development, we characterize the features of authentic DCs within the meninges and choroid plexus in healthy mouse brains...
- Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis
Neurophysiology Unit, Laboratory Organ, System Pathophysiology, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
J Neuroimmunol 148:11-23. 2004
..structures containing B cells and a reticulum of CXCL13+ and FDC-M1+ follicular dendritic cells within the meninges of several mice undergoing progressive relapsing EAE...
- Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis
Center for Neurological Diseases, Brigham and Women s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
Ann Neurol 65:457-69. 2009
..We hypothesized that activated CD4(+) T cells gain direct access to the subarachnoid space and become reactivated on encounter with cognate antigen in this compartment...
- Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice
Holly R Chinnery
University of Western Australia, Centre for Ophthalmology and Visual Sciences and Lions Eye Institute, Perth, Western Australia
J Neuropathol Exp Neurol 69:896-909. 2010
..chimeric mice to characterize the phenotype, density and replenishment rate of monocyte-derived cells in the meninges and choroid plexus and to assess the role of the chemokine receptor CX3CR1 on their number and tissue ..
- Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges
Roberto De Col
Institute for Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
J Physiol 586:1089-103. 2008
..conduction velocity changes during repetitive activation of single unmyelinated axons innervating the rat cranial meninges. In direct contradiction to the currently accepted postulate, Na(+)-K(+)-ATPase blockade actually enhanced ..
- Wegener granulomatosis: MR imaging findings in brain and meninges
J M Murphy
Department of Radiology, Addenbrooke s Hospital, England
Radiology 213:794-9. 1999
..To determine the spectrum of intracranial magnetic resonance (MR) imaging appearances of Wegener granulomatosis...
- Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache
University of Arizona School of Medicine, Department of Pharmacology, Tucson, AZ 85724, USA
Pain 152:106-13. 2011
..In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology...
- Novel extracellular matrix structures in the neural stem cell niche capture the neurogenic factor fibroblast growth factor 2 from the extracellular milieu
John A Burns School of Medicine, Department of Tropical Medicine and Infectious Diseases, University of Hawaii, Honolulu, Hawaii 96813, USA
Stem Cells 25:2146-57. 2007
..These results strongly suggest that fractones promote growth factor activity in the neural stem cell niche...
- A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation
Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA
Neuron 73:698-712. 2012
..By using mice either with meningeal overgrowth or selective loss of meninges, we have identified a cascade of morphogenic signals initiated by the meninges that regulates corpus callosum ..
- Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure
National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 9502, USA
Synapse 64:579-93. 2010
..The present study evaluates the effect of AMPH on several ERSR elements in meninges and associated vasculature (MAV), parietal cortex, and striatum...
- Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
Nature 462:94-8. 2009
..These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations...
- Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
Owain W Howell
Centre for Neuroscience, Division of Experimental Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London W12 0NN, UK
Brain 134:2755-71. 2011
- Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Nat Neurosci 9:1284-93. 2006
..we demonstrate that the tangential migration of cortical hem-derived Cajal-Retzius cells is controlled by the meninges. We show that the meningeal membranes are a necessary and sufficient substrate for the tangential migration of ..
- Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development
Department of Neurology, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
Proc Natl Acad Sci U S A 104:14002-7. 2007
..mice contributes to the cortical and skull defects in mutant mice and that the prominent phenotypes appear as the meninges differentiate into pia, arachnoid, and dura...
- Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche
Department of Clinical and Experimental Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy
J Cell Mol Med 13:3195-208. 2009
..As leptomeninges cover the entire central nervous system, these findings could have relevant implications for studies on cortical development and for regenerative medicine applied to neurological disorders...
- Tumefactive fibroinflammatory lesion of the neck with progressive invasion of the meninges, skull base, orbit, and brain
A I Holodny
Department of Radiology, New Jersey Medical School, University Hospital, 150 Bergen Street, Newark, NJ 07103, USA
AJNR Am J Neuroradiol 22:876-9. 2001
..fibroinflammatory lesion that originated in the left side of the neck and progressed over 2 years to involve the meninges, the cavernous sinuses, the right temporal lobe, and the right orbit...
- Intracranial meningeal disease: comparison of contrast-enhanced MR imaging with fluid-attenuated inversion recovery and fat-suppressed T1-weighted sequences
Department of Radiology, University of California, San Diego, Medical Center, San Diego, California 92103 8756, USA
AJNR Am J Neuroradiol 26:553-9. 2005
..The purpose of this study was to compare contrast-enhanced T1-weighted MR images with fat suppression to contrast-enhanced FLAIR images to determine which sequence was superior for depicting meningeal disease...
- Expression of transforming growth factor-beta receptors in meningeal fibroblasts of the injured mouse brain
Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183 8526, Japan
Cell Mol Neurobiol 30:101-11. 2010
..After 5 days postinjury, many fibroblasts migrated from the meninges to the lesion site formed the fibrotic scar, and most of them expressed TGF-beta receptors...
- Olfactory nerve--a novel invasion route of Neisseria meningitidis to reach the meninges
Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
PLoS ONE 5:e14034. 2010
..epithelium, along olfactory nerves in the cribriform plate, at the olfactory bulb and subsequently at the meninges and subarachnoid space...
- EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury
Julia E Herrmann
Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093 0691, USA
Exp Neurol 223:582-98. 2010
..In contrast to what has been proposed, these data do not support a major role for EphA4 in reactive astrogliosis following SCI...
- An in vitro model of the inhibition of axon growth in the lesion scar formed after central nervous system injury
Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
Mol Cell Neurosci 43:177-87. 2010
..Therefore, this culture system can be available to analyze the inhibitory property in the lesion site of CNS...
- Regulation of radial glial survival by signals from the meninges
The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA
J Neurosci 29:7694-705. 2009
..Apoptosis is also induced by surgical removal of the meninges. Finally, mice lacking the BM components laminin alpha2 and alpha4 show defects in the attachment of RGC ..
- The microvasculature of the human cerebellar meninges
Department of Pathology, Toho University School of Medicine, 5 21 16 Ohmori nishi, Ohtaku, Tokyo 143 8540, Japan
Acta Neuropathol 104:608-14. 2002
The vascular architecture of the human cerebellar meninges was investigated. The surface meninges were poor in vasculature. In the sulci, the meninges were highly vascular but had few capillaries...
- A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus
Department of Psychology, University of Colorado, Boulder, CO, USA
Brain Behav Immun 21:711-8. 2007
..spinal cord glia are the sole source of CSF cytokines may be an underestimate, as the cellular composition of the meninges surrounding the spinal cord CSF space includes several cell types known to produce proinflammatory cytokines...
- Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation
Molecular Bacteriology and Immunology Group, Division of Microbiology and Infectious Diseases, University Hospital, Nottingham, NG7 2UH, UK
Cell Microbiol 6:927-38. 2004
..Secreted meningococcal virulence factors are therefore important in inducing host inflammatory responses and resistance to apoptosis, and they are worthy of extensive investigation...
- Intrathecal epidermal growth factor and fibroblast growth factor-2 exacerbate meningeal proliferative lesions associated with intrathecal catheters
Ann M Parr
Neurosurgery 60:926-33; discussion 926-33. 2007
..We studied this proliferation in a minimal injury rat model in the presence of epidermal growth factor and fibroblast growth factor-2...
- Morphological changes of the retrobulbar optic nerve and its meningeal sheaths in glaucoma
University Eye Clinic Freiburg, Freiburg, Germany
Ophthalmologica 220:393-6. 2006
..Occurrence and amount of meningo- thelial cell nests in the subarachnoid space were however significantly increased in glaucoma (p < 0.02). Whether this observation is glaucoma specific deserves further investigation...
- The astrocyte/meningeal cell interface--a barrier to successful nerve regeneration?
M C Shearer
Department of Physiology, University of Cambridge, England
Cell Tissue Res 305:267-73. 2001
..The distribution of cell surface and matrix molecules on these cultures is described, and the effect of various pharmacological interventions which can affect axon growth between the two cell types is summarised in this review...
- Leptomeningeal disease from oligodendroglioma: clinical and molecular analysis
Department of Oncology, Tom Baker Cancer Centre, Alberta Cancer Board, University of Calgary, Calgary, Alberta Canada
Can J Neurol Sci 35:204-9. 2008
..A long surviving case led us to review our experience with LMD in patients with oligodendrogliomas...
- Expression of nestin, mesothelin and epithelial membrane antigen (EMA) in developing and adult human meninges and meningiomas
Department of Pathology, Cytology and Forensic Medicine, University Clinical Hospital Mostar, Bosnia and Herzegovina
Acta Histochem 113:703-11. 2011
..and mesothelin proteins was immunohistochemically determined in the cells of normal developing and adult human meninges and meningiomas. Human meninges developed as two mesenchymal condensations in the head region...
- Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells
Lars Ove Brandenburg
Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
J Neuroimmunol 217:55-64. 2009
Bacterial meningitis is characterized by an inflammation of the meninges and continues to be an important cause of mortality and morbidity...
- Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells
Department of Clinical Veterinary Medicine, University of Cambridge, UK
Brain 126:598-609. 2003
..These results highlight the important concept that the regenerative properties of OECs are profoundly influenced by the cells with which they are transplanted...
- Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis
Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
Brain Pathol 19:238-53. 2009
..Our study provides evidence of substantial archaeocortical pathology largely resembling patterns seen in the neocortex and suggests that hippocampal involvement could contribute to memory impairments often seen in MS...
- CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges
Stroke Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114
Br J Pharmacol 106:409-15. 1992
..Bacterial, viral(including AIDS meningovascular inflammation) and other forms of chemical meningitis merit further investigation...
- The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways
Morven C Shearer
Department of Physiology and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 3EG, England, UK
Mol Cell Neurosci 24:913-25. 2003
..Increasing cAMP levels and inactivation of rho were both effective when the cultures were fixed in paraformaldehyde, demonstrating that their effect is on axons and not via effects on the glial cells...
- Anatomy and development of the meninges: implications for subdural collections and CSF circulation
Department of Radiology, Penn State Hershey Medical Center, 30 Hope Drive, Suite 1800, P O Box 859, Hershey, PA, 17033 0859, USA
Pediatr Radiol 39:200-10. 2009
..This review outlines the development and age-specific vascularity of the dura and offers an alternative perspective on the role of the dura in homeostasis of the central nervous system...
- Histological evidence for drug diffusion across the cerebral meninges into the underlying neocortex in rats
NYU Comprehensive Epilepsy Center, Department of Neurology, NYU School of Medicine, New York, NY 10016, USA
Brain Res 1188:228-32. 2008
..the extent to which a marker compound, N-methyl-D-aspartate (NMDA), can diffuse into the neocortex through the meninges. Rats were implanted with bilateral parietal cortical epidural cups filled with 50 mM NMDA on the right side and ..
- Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection
Department of Medical Biochemistry and Biophysics, Scheeles vag 2, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Infect Immun 74:6982-91. 2006
..rarely infected, which has mainly been ascribed to the protective functions of the blood-brain barrier (BBB) and meninges. Since the bactericidal properties of the BBB and meninges are not known, we hypothesized that antimicrobial ..
- Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I
Division of Medical Genetics, Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance CA, USA
Mol Genet Metab 83:163-74. 2004
..whether intrathecal (IT) recombinant human alpha-L-iduronidase (rhIDU) could penetrate and treat the brain and meninges. An initial dose-response study showed that doses of 0.46-4...
- Patterns of contrast enhancement in the brain and meninges
James G Smirniotopoulos
Department of Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD 20813, USA
Radiographics 27:525-51. 2007
..Understanding the classic patterns of lesion enhancement--and the radiologic-pathologic mechanisms that produce them--can improve image assessment and differential diagnosis...
- Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in mice
Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
J Neurosci Methods 194:108-15. 2010
Abnormal microcirculation within meninges is common in many neurological diseases. There is a need for an imaging method that is capable of monitoring dynamic meningeal microcirculations, preferably decoupled from cortical blood flow...
- Parasellar solitary fibrous tumor of meninges: magnetic resonance imaging features with pathologic correlation
Chung Ping Lo
Department of Radiology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC
J Neuroimaging 14:281-4. 2004
..The authors report the case of a 50-year-old man with SFT arising from the meninges of the left parasellar region with cavernous sinus involvement...
- FLAIR MR imaging for diagnosing intracranial meningeal carcinomatosis
Department of Radiology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan
AJR Am J Roentgenol 176:1585-8. 2001
..Contrast-enhanced FLAIR images can sometimes surpass contrast-enhanced T1-weighted images in their quality...
- HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues
Susanna L Lamers
Polytechnic Institute of New York University, Brooklyn, NY, USA
Infect Genet Evol 11:31-7. 2011
..Interestingly, the major tissue harboring virus from both the brain and peripheral tissues was the meninges. These results show that (1) HIV-1 is clearly capable of migrating out of the brain, (2) the meninges are the ..
- Prevalence of psammoma bodies in meninges and choroid plexuses of raccoons (Procyon lotor) from Parramore Island, Virginia
A N Hamir
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
J Vet Diagn Invest 13:76-9. 2001
..Most mineralized foci had concentric laminations and were present in small capillaries of meninges of the brain (15/33), in choroid plexus (3/33), or at both these sites (13/33)...
- The meninges is a source of retinoic acid for the late-developing hindbrain
E Kennedy Shriver Center, University of Massachusetts Medical School, University of Massachusetts, Waltham, Massachusetts 02452, USA
J Neurosci 23:7610-20. 2003
..the hindbrain from the RA synthetic enzyme retinaldehyde dehydrogenase-2 (RALDH2) present in the surrounding meninges and mesenchyme by embryonic day 13...
- Meningeal cells induce dopaminergic neurons from embryonic stem cells
Department of Biological Repair, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
Eur J Neurosci 27:261-8. 2008
..These results indicate that meningeal cells can be used as feeders to induce DA neurons from ES cells, and that Wnt-5a plays an important role in DA neuron induction by SDIA...
- Extranodal Rosai-Dorfman disease involving the meninges
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
South Med J 95:1101-2. 2002
..Meningeal biopsy revealed Rosai-Dorfman disease. Sinus histiocytosis may mimic meningeal disease, and Rosai-Dorfman disease should be considered in the differential diagnosis of dural-based masses with diffuse leptomeningeal enhancement...
- Maternalizing the meninges: a pregnant Arabic legacy
Neurol India 54:345-6. 2006
- Microvasculature of the human cerebral meninges
Department of Pathology, Toho University School of Medicine, Ohta ku, Tokyo, Japan
Neuropathology 23:129-35. 2003
In the present study, the human cerebral meninges were rich in blood vessels, but no capillaries were noted. The meningeal arteries ran over the veins where they crossed. Several arterial anastomoses existed on the cortical surface...
- Lymphatic drainage of the cerebrospinal fluid from monkey spinal meninges with special reference to the distribution of the epidural lymphatics
Department of Anatomy, Oita Medical University, Japan
Arch Histol Cytol 61:277-86. 1998
..structural organization of the epidural lymphatics and lymphatic drainage of the cerebrospinal fluid from spinal meninges was studied in Japanese monkeys (Macaca fuscata) by an enzyme-histochemical method...
- [What is your diagnosis?]
Service de Neurologie, CHU Nancy, France
J Neuroradiol 31:397-8. 2004
- Lateral transsulcal approach to asymptomatic trigonal meningiomas with correlative microsurgical anatomy: technical case report
Department of Neurosurgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Neurosurgery 56:E438; discussion E438. 2005
..We introduce the lateral transsulcal approach to asymptomatic trigonal meningiomas...
- Subacute aseptic meningitis as neurological manifestation of primary Sjögren's syndrome
Unit of Neurology, San Francesco Hospital, via Mannironi, 08100 Nuoro, Italy
Clin Neurol Neurosurg 108:688-91. 2006
- Herpes simplex encephalitis
Sean W Taylor
Department of Medicine Neurology, Queen s University, Kingston, Ontario, Canada
Can J Neurol Sci 32:246-7. 2005
- CNS myelomatosis
Vitalie D Lupu
EMG Section, National Institute of Neurologic Disorders and Stroke, NIH, Bldg 10, Room 5C101, 10 Center Drive MSC 1404, Bethesda, MD 20892 1404, USA
Neurology 64:1007. 2005
- Ribosome-lamella complex in aggressive solitary fibrous tumour of the meninges
Acta Neuropathol 110:312-4. 2005
- Delayed occurrence of intracranial supratentorial chondroma following compound depressed skull fracture
J T Hong
Department of Neurosurgery, St Vincent Hospital, The Catholic University of Korea, Chi dong, Paldal Ku, Suwon, Korea
Acta Neurochir (Wien) 147:343-5; discussion 345. 2005
- Incidentally detected parafalcine chondrosarcoma
Department of Neurosurgery, Gunma University Graduate School of Medicine, Gunma, Japan
Acta Neurochir (Wien) 147:795-9; discussion 799. 2005
..SPECT using (201)TlCl and (123)I-IMP may be useful to discriminate parafalcine low-grade chondrosarcoma from meningioma or other tumours originating in this region...
- Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients
Department of Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
Neurology 71:1102-8. 2008
..We prospectively evaluated the diagnostic value of PCR in comparison with CSF cytomorphology and MRI for diagnosing meningeal dissemination in PCNSL...
- Anterior cranial base glioneuronal heterotopia
Division of Neurosurgery, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
Childs Nerv Syst 22:227-33. 2006
Cranial base glioneuronal heterotopia is a nest or linear array of glioneuronal tissue within the basal meninges. It is thought to arise from aberrant migration of embryonic neuroepithelial tissues into the subarachnoid space...
- [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle]
Horst J Koch
Neurologische Universitätsklinik Regensburg, Deutschland
Wien Med Wochenschr 155:360-4. 2005
..This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse. Secondary malignisation of the melancytoma is suggested...
- Low cerebrospinal fluid pressure syndromes
Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
Neurol Clin 22:55-74, vi. 2004
..Some of the older concepts or presumptions have been challenged while novel observations continue to appear in the literature. We are still in the learning phase...
- Growth rate of non-operated meningiomas
L A Zeidman
Dept of Neurology, Northwestern University, 710 N Lake Shore Drive, Abbott Hall, 1115, Chicago, IL 60611, USA
J Neurol 255:891-5. 2008
..Some meningiomas grow slowly or seemingly not at all with planimetric measurement. Volumetric measurement may be more accurate because tumors may grow in different directions than the planimetric axes...
- [Cerebral amyloid angiopathy]
Groupe hospitalier Joffre Dupuytren, Draveil
Psychol Neuropsychiatr Vieil 5:35-45. 2007
..Recent progresses in the field of MRI make the diagnosis of cerebral amyloid angiopathy easier and more accurate. MRI should be more frequently performed in aged patients...
- [Sinonasal and cerebral imaging findings in Wegener's granulomatosis]
Service de Radiologie A, Hopital Cochin, Paris, France
Presse Med 36:913-21. 2007
..These imaging findings of Wegener's granulomatosis are nonspecific. They should be combined with clinical examination and c-ANCA tests to confirm the diagnosis...
- A case of sarcoidosis presenting as a non-specific intramedullary lesion
Section of Neurology, Department of Neuroscience, University of Pisa, Pisa, Italy
Eur J Neurol 14:346-9. 2007