meninges

Summary

Top Publications

  1. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
  2. doi Telocytes in meninges and choroid plexus
    B O Popescu
    Department of Neurology, University Hospital, Carol Davila Medical University, Bucharest, Romania
    Neurosci Lett 516:265-9. 2012
  3. doi Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE
    Alison L Christy
    Northwestern University, Feinberg School of Medicine, Department of Microbiology and Immunology, Chicago, IL, USA
    J Autoimmun 42:50-61. 2013
  4. ncbi Migraine pain, meningeal inflammation, and mast cells
    Dan Levy
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E CLS639, Boston, MA 02215, USA
    Curr Pain Headache Rep 13:237-40. 2009
  5. pmc Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010
  6. ncbi Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    Barbara Serafini
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Brain Pathol 14:164-74. 2004
  7. ncbi Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats
    Liza Q Bundesen
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 23:7789-800. 2003
  8. ncbi Retinoic acid synthesis for the developing telencephalon
    D Smith
    Eunice Kennedy Shriver Center for Mental Retardation, Waltham, MA 02452, USA
    Cereb Cortex 11:894-905. 2001
  9. pmc The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates
    Asmaa Tazi
    Institut Cochin, Université Paris Descartes Faculté de Médecine, Centre National de la Recherche Scientifique UMR 8104, 75014 Paris, France
    J Exp Med 207:2313-22. 2010
  10. ncbi Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy
    Paul G McMenamin
    School of Anatomy and Human Biology, University of Western Australia, 35 Stirling Highway, 6009 Crawley, Perth, Western Australia, Australia
    Cell Tissue Res 313:259-69. 2003

Detail Information

Publications275 found, 100 shown here

  1. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
    ..In this study we demonstrate that the dorsal forebrain meninges communicate with the adjacent radial glial endfeet and influence cortical development...
  2. doi Telocytes in meninges and choroid plexus
    B O Popescu
    Department of Neurology, University Hospital, Carol Davila Medical University, Bucharest, Romania
    Neurosci Lett 516:265-9. 2012
    ..We report here identification of TCs by electron microscopy and immunofluorescence in rat meninges and choroid plexus/subventricular zone, in the vicinity of putative stem cells...
  3. doi Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE
    Alison L Christy
    Northwestern University, Feinberg School of Medicine, Department of Microbiology and Immunology, Chicago, IL, USA
    J Autoimmun 42:50-61. 2013
    The meninges are often considered inert tissues that house the CSF and provide protection for the brain and spinal cord. Yet emerging data demonstrates that they are also active sites of immune responses...
  4. ncbi Migraine pain, meningeal inflammation, and mast cells
    Dan Levy
    Headache Research Laboratory, Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, E CLS639, Boston, MA 02215, USA
    Curr Pain Headache Rep 13:237-40. 2009
    ..and the subsequent activation of trigeminal primary afferent nociceptive neurons that supply the intracranial meninges and their related large blood vessels...
  5. pmc Regulation of learning and memory by meningeal immunity: a key role for IL-4
    Noel C Derecki
    Department of Neuroscience, University of Virginia, Charlottesville, VA 22908, USA
    J Exp Med 207:1067-80. 2010
    ..Performance of cognitive tasks led to accumulation of IL-4-producing T cells in the meninges. Depletion of T cells from meningeal spaces skewed meningeal myeloid cells toward a proinflammatory phenotype...
  6. ncbi Detection of ectopic B-cell follicles with germinal centers in the meninges of patients with secondary progressive multiple sclerosis
    Barbara Serafini
    Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    Brain Pathol 14:164-74. 2004
    ..and plasma cells, and a network of follicular dendritic cells producing CXCL13 were observed in the cerebral meninges of 2 out of 3 patients with secondary progressive MS, but not in relapsing remitting and primary progressive MS...
  7. ncbi Ephrin-B2 and EphB2 regulation of astrocyte-meningeal fibroblast interactions in response to spinal cord lesions in adult rats
    Liza Q Bundesen
    Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20057, USA
    J Neurosci 23:7789-800. 2003
    ..by reactive CNS astrocytes, and EphB2 is present on fibroblasts invading the lesion site from the adjacent meninges. During the first 3 d after injury, there is intermingling of ephrin-B2-expressing reactive astrocytes at the ..
  8. ncbi Retinoic acid synthesis for the developing telencephalon
    D Smith
    Eunice Kennedy Shriver Center for Mental Retardation, Waltham, MA 02452, USA
    Cereb Cortex 11:894-905. 2001
    ..Because of its diffusible character, retinoic acid represents a unique tool for the coordination of growth processes over an intermediate distance range in the developing telencephalon...
  9. pmc The surface protein HvgA mediates group B streptococcus hypervirulence and meningeal tropism in neonates
    Asmaa Tazi
    Institut Cochin, Université Paris Descartes Faculté de Médecine, Centre National de la Recherche Scientifique UMR 8104, 75014 Paris, France
    J Exp Med 207:2313-22. 2010
    ..In conclusion, HvgA is a critical virulence trait of GBS in the neonatal context and stands as a promising target for the development of novel diagnostic and antibacterial strategies...
  10. ncbi Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy
    Paul G McMenamin
    School of Anatomy and Human Biology, University of Western Australia, 35 Stirling Highway, 6009 Crawley, Perth, Western Australia, Australia
    Cell Tissue Res 313:259-69. 2003
    ..provides novel information on the topographical distribution of macrophages and dendritic cells (DCs) in normal meninges and choroid plexus of the rat central nervous system (CNS)...
  11. ncbi Microscopic morphology and histology of the human meninges
    R O Weller
    Clinical Neurosciences, Southampton University School of Medicine, Mail Point 813, Southampton General Hospital, Southampton SO16 6YD, UK
    Morphologie 89:22-34. 2005
    The meninges comprise the dura mater and the leptomeninges (arachnoid and pia mater). Dura forms an outer endosteal layer related to the bones of the skull and spine and an inner layer closely applied to the arachnoid mater...
  12. pmc Nestin- and doublecortin-positive cells reside in adult spinal cord meninges and participate in injury-induced parenchymal reaction
    Ilaria Decimo
    Department of Public Health and Community Medicine, Section of Pharmacology, University of Verona, Verona, Italy
    Stem Cells 29:2062-76. 2011
    ..In this study, we describe a new population of cells resident in the adult rat spinal cord meninges that express the neural stem/precursor markers nestin and doublecortin...
  13. pmc Deciphering the contribution of human meningothelial cells to the inflammatory and antimicrobial response at the meninges
    Pierre Joseph Royer
    School of Molecular Medical Sciences and School of Biomedical Sciences, University of Nottingham, Nottingham, United Kingdom
    Infect Immun 81:4299-310. 2013
    ..It also sheds light on the complexity of intracellular signaling after TLR triggering. ..
  14. doi Grey matter pathology in multiple sclerosis
    Jeroen J G Geurts
    Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands
    Lancet Neurol 7:841-51. 2008
    ..These hypotheses remain to be validated over the coming years, and could substantially affect our current views on MS pathogenesis...
  15. pmc Immunoreactivity for GABA, GAD65, GAD67 and Bestrophin-1 in the meninges and the choroid plexus: implications for non-neuronal sources for GABA in the developing mouse brain
    Shiro Tochitani
    Department of Anatomy and Developmental Neurobiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    PLoS ONE 8:e56901. 2013
    ..Recent studies revealed that the meninges and the cerebrospinal fluid have certain roles to regulate brain development...
  16. pmc Meningeal cells and glia establish a permissive environment for axon regeneration after spinal cord injury in newts
    Katherine A Zukor
    Interdepartmental Program in Neuroscience, University of Utah, Salt Lake City, UT 84132, USA
    Neural Dev 6:1. 2011
    ....
  17. ncbi Lagochilascariasis leading to severe involvement of ocular globes, ears and meninges
    Renata T R Aquino
    Faculdade de Ciencias Medicas, Santa Casa de Sao Paulo, Sao Paulo, SP, Brasil
    Rev Inst Med Trop Sao Paulo 50:355-8. 2008
    ..woman from Paraíba State (North-Eastern Brazil) that presented severe involvement of ocular globes, ears and meninges. Diagnosis was established after enucleation of her left eye, when adult worms were seen in the midst of a ..
  18. doi hebp3, a novel member of the heme-binding protein gene family, is expressed in the medaka meninges with higher abundance in females due to a direct stimulating action of ovarian estrogens
    Kiyoshi Nakasone
    Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo, Tokyo 113 8657, Japan
    Endocrinology 154:920-30. 2013
    ..The medaka hebp3 is expressed in the meninges with higher abundance in females, whereas there is no expression within the brain parenchyma...
  19. ncbi Central origin of IL-1beta produced during peripheral inflammation: role of meninges
    B V Garabedian
    Laboratoire Développement et Vieillissement du Système Nerveux DVSN, Institut des Neurosciences, CNRS UMR 7624, Universite Pierre et Marie Curie, 9 quai Saint Bernard, 75005, Paris, France
    Brain Res Mol Brain Res 75:259-63. 2000
    ..We measured IL-1beta mRNA in the cerebellum, hippocampus and cerebral cortex collected with meninges and in the same structures collected without meninges after a peripheral lipopolysaccharide (LPS) stimulation (0...
  20. doi Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature
    Monzy Thomas
    US Food and Drug Administration, National Center for Toxicological Research, Division of Neurotoxicology, 3900 NCTR Road, Jefferson, Arkansas 72079, USA
    Synapse 63:881-94. 2009
    ..Rats were sacrificed either 3 h or 1 day after dosing, and total RNA and protein was isolated from the meninges, arachnoid and pia membranes, and associated vasculature (MAV) that surround the forebrain...
  21. pmc Developmental changes of mast cell populations in the cerebral meninges of the rat
    Helen Michaloudi
    Laboratory of Anatomy and Histology, Veterinary School, Aristotle University of Thessaloniki, Greece
    J Anat 211:556-66. 2007
    ..The present study shows that unevenly distributed mast cells in the cerebral meninges of the rat can be found in perivascular sites and vessel ramification points, but can also be unrelated to the ..
  22. ncbi Inflammatory myofibroblastic tumor of the orbit with associated enhancement of the meninges and multiple cranial nerves
    A M McKinney
    Department of Radiology, University of Minnesota Medical School and Hennepin County Medical Center, Minneapolis 55415, USA
    AJNR Am J Neuroradiol 27:2217-20. 2006
    ....
  23. ncbi Different meningitis-causing bacteria induce distinct inflammatory responses on interaction with cells of the human meninges
    Mark I Fowler
    Molecular Microbiology and Infection, Division of Infection, Inflammation and Repair, University of Southampton Medical School, Southampton General Hospital, Southampton SO16 6YD, UK
    Cell Microbiol 6:555-67. 2004
    ....
  24. pmc Spontaneous locomotor activity correlates with the degranulation of mast cells in the meninges rather than in the thalamus: disruptive effect of cocaine
    Alice A Larson
    Department of Veterinary and Biomedical Sciences, University of Minnesota, 1988 Fitch Avenue, Room 295, St Paul, MN 55108, USA
    Brain Res 1395:30-7. 2011
    ..of cocaine on circulating corticosterone, motor activity and degranulation of mast cells in both the thalamus and meninges of mice...
  25. doi The effects of subarachnoid administration of preservative-free S(+)-ketamine on spinal cord and meninges in dogs
    Alfredo Cury Rojas
    Anesthesiology Department, Sao Paulo State University, Botucatu SP, Brazil
    Anesth Analg 114:450-5. 2012
    ..In this study we evaluated the effects of a single dose of preservative-free S(+)-ketamine, in doses usually used in clinical practice, in the spinal cord and meninges of dogs.
  26. ncbi Distribution and phenotype of dendritic cells and resident tissue macrophages in the dura mater, leptomeninges, and choroid plexus of the rat brain as demonstrated in wholemount preparations
    P G McMenamin
    Department of Anatomy and Human Biology, University of Western Australia, Nedlands
    J Comp Neurol 405:553-62. 1999
    ..Until now it has been assumed DC are largely absent from the brain, meninges, and the choroid plexus within the ventricles...
  27. doi Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly
    Takashi Inoue
    Laboratory for Comparative Neurogenesis Behavioral and Developmental Disorders, RIKEN Brain Science Institute, Wako Shi, Saitama 351 0198, Japan
    J Neurosci 28:4712-25. 2008
    ..These findings indicate that the Zic genes play critical roles in cortical development through regulating the proliferation of meningeal cells and the pial BM assembly...
  28. ncbi Neuronal, glial, and epithelial localization of gamma-aminobutyric acid transporter 2, a high-affinity gamma-aminobutyric acid plasma membrane transporter, in the cerebral cortex and neighboring structures
    F Conti
    Institute of Human Physiology, University of Ancona, Italy
    J Comp Neurol 409:482-94. 1999
    ..The widespread cellular expression of GAT-2 suggests that it may have several functional roles in the overall regulation of GABA levels in the brain...
  29. ncbi Innate response to focal necrotic injury inside the blood-brain barrier
    Jiyun V Kim
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, Department of Pathology, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 177:5269-77. 2006
    ..Necrotic injury in the meninges, but not the brain parenchyma, recruited GFP+ cells within minutes that fully surrounded the necrotic site within ..
  30. pmc Differential gene expression during meningeal-meningococcal interaction: evidence for self-defense and early release of cytokines and chemokines
    D B Wells
    Molecular Bacteriology and Immunology Group, Divisions of Microbiology and Infectious Diseases, University Hospital, Queen's Medical Centre, Nottingham, NG7 2UH, United Kingdom
    Infect Immun 69:2718-22. 2001
    ..Also, a trend in up-regulation of anti-apoptotic genes and down-regulation of pro-apoptotic genes was observed. This is the first evidence that meningothelial cells may mount cytoprotective responses to pathogenic bacteria...
  31. pmc Related B cell clones populate the meninges and parenchyma of patients with multiple sclerosis
    Laura Lovato
    Department of Neurology, Yale School of Medicine, New Haven, CT 06510, USA
    Brain 134:534-41. 2011
    In the central nervous system of patients with multiple sclerosis, B cell aggregates populate the meninges, raising the central question as to whether these structures relate to the B cell infiltrates found in parenchymal lesions or ..
  32. doi Group B Streptococcus surface proteins as major determinants for meningeal tropism
    Asmaa Tazi
    Institut Cochin, Université Paris Descartes Sorbonne Paris Cité, CNRS UMR 8104, Paris, France
    Curr Opin Microbiol 15:44-9. 2012
    ....
  33. pmc We have got you 'covered': how the meninges control brain development
    Julie A Siegenthaler
    Department of Neurology, Programs in Neuroscience and Developmental Biology, Institute for Regenerative Medicine, University of California, San Francisco, San Francisco, CA 94158, United States
    Curr Opin Genet Dev 21:249-55. 2011
    The meninges have traditionally been viewed as specialized membranes surrounding and protecting the adult brain from injury. However, there is increasing evidence that the fetal meninges play important roles during brain development...
  34. pmc Comparison of the inflammatory responses of human meningeal cells following challenge with Neisseria lactamica and with Neisseria meningitidis
    Mark I Fowler
    Molecular Microbiology Group, Division of Infection, Inflammation and Repair, Mailpoint 814, University of Southampton Medical School, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom
    Infect Immun 74:6467-78. 2006
    ..for the present study was to determine how different species of bacteria interact with cells of the human meninges in order to gain information that would have broad relevance to understanding aspects of the innate immune ..
  35. pmc Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain
    Niroshana Anandasabapathy
    Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10065, USA
    J Exp Med 208:1695-705. 2011
    ..receptor tyrosine kinase 3)-dependent development, we characterize the features of authentic DCs within the meninges and choroid plexus in healthy mouse brains...
  36. ncbi Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental autoimmune encephalomyelitis
    Roberta Magliozzi
    Neurophysiology Unit, Laboratory Organ, System Pathophysiology, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Roma, Italy
    J Neuroimmunol 148:11-23. 2004
    ..structures containing B cells and a reticulum of CXCL13+ and FDC-M1+ follicular dendritic cells within the meninges of several mice undergoing progressive relapsing EAE...
  37. pmc Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis
    Pia Kivisakk
    Center for Neurological Diseases, Brigham and Women s Hospital, Department of Neurology, Harvard Medical School, Boston, MA 02115, USA
    Ann Neurol 65:457-69. 2009
    ..We hypothesized that activated CD4(+) T cells gain direct access to the subarachnoid space and become reactivated on encounter with cognate antigen in this compartment...
  38. doi Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice
    Holly R Chinnery
    University of Western Australia, Centre for Ophthalmology and Visual Sciences and Lions Eye Institute, Perth, Western Australia
    J Neuropathol Exp Neurol 69:896-909. 2010
    ..chimeric mice to characterize the phenotype, density and replenishment rate of monocyte-derived cells in the meninges and choroid plexus and to assess the role of the chemokine receptor CX3CR1 on their number and tissue ..
  39. pmc Conduction velocity is regulated by sodium channel inactivation in unmyelinated axons innervating the rat cranial meninges
    Roberto De Col
    Institute for Physiology and Pathophysiology, University of Erlangen Nuremberg, Erlangen, Germany
    J Physiol 586:1089-103. 2008
    ..conduction velocity changes during repetitive activation of single unmyelinated axons innervating the rat cranial meninges. In direct contradiction to the currently accepted postulate, Na(+)-K(+)-ATPase blockade actually enhanced ..
  40. ncbi Wegener granulomatosis: MR imaging findings in brain and meninges
    J M Murphy
    Department of Radiology, Addenbrooke s Hospital, England
    Radiology 213:794-9. 1999
    ..To determine the spectrum of intracranial magnetic resonance (MR) imaging appearances of Wegener granulomatosis...
  41. pmc Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache
    Jin Yan
    University of Arizona School of Medicine, Department of Pharmacology, Tucson, AZ 85724, USA
    Pain 152:106-13. 2011
    ..In trigeminal neurons retrogradely labeled from the cranial meninges, we have recorded pH-evoked currents using whole-cell patch-clamp electrophysiology...
  42. ncbi Novel extracellular matrix structures in the neural stem cell niche capture the neurogenic factor fibroblast growth factor 2 from the extracellular milieu
    Aurelien Kerever
    John A Burns School of Medicine, Department of Tropical Medicine and Infectious Diseases, University of Hawaii, Honolulu, Hawaii 96813, USA
    Stem Cells 25:2146-57. 2007
    ..These results strongly suggest that fractones promote growth factor activity in the neural stem cell niche...
  43. pmc A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation
    Youngshik Choe
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 73:698-712. 2012
    ..By using mice either with meningeal overgrowth or selective loss of meninges, we have identified a cascade of morphogenic signals initiated by the meninges that regulates corpus callosum ..
  44. doi Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure
    Monzy Thomas
    National Center for Toxicological Research, U S Food and Drug Administration, Jefferson, AR 72079 9502, USA
    Synapse 64:579-93. 2010
    ..The present study evaluates the effect of AMPH on several ERSR elements in meninges and associated vasculature (MAV), parietal cortex, and striatum...
  45. doi Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions
    Ingo Bartholomäus
    Max Planck Institute for Neurobiology, 82152 Martinsried, Germany
    Nature 462:94-8. 2009
    ..These contacts stimulated the effector T cells to produce pro-inflammatory mediators, and provided a trigger to tissue invasion and the formation of inflammatory infiltrations...
  46. doi Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis
    Owain W Howell
    Centre for Neuroscience, Division of Experimental Medicine, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, Burlington Danes Building, Du Cane Road, London W12 0NN, UK
    Brain 134:2755-71. 2011
    ....
  47. ncbi Meninges control tangential migration of hem-derived Cajal-Retzius cells via CXCL12/CXCR4 signaling
    Victor Borrell
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    Nat Neurosci 9:1284-93. 2006
    ..we demonstrate that the tangential migration of cortical hem-derived Cajal-Retzius cells is controlled by the meninges. We show that the meningeal membranes are a necessary and sufficient substrate for the tangential migration of ..
  48. pmc Cortical dysplasia and skull defects in mice with a Foxc1 allele reveal the role of meningeal differentiation in regulating cortical development
    Konstantinos Zarbalis
    Department of Neurology, University of California, 1550 Fourth Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 104:14002-7. 2007
    ..mice contributes to the cortical and skull defects in mutant mice and that the prominent phenotypes appear as the meninges differentiate into pia, arachnoid, and dura...
  49. doi Novel stem/progenitor cells with neuronal differentiation potential reside in the leptomeningeal niche
    Francesco Bifari
    Department of Clinical and Experimental Medicine, Stem Cell Research Laboratory, Section of Hematology, University of Verona, Verona, Italy
    J Cell Mol Med 13:3195-208. 2009
    ..As leptomeninges cover the entire central nervous system, these findings could have relevant implications for studies on cortical development and for regenerative medicine applied to neurological disorders...
  50. ncbi Tumefactive fibroinflammatory lesion of the neck with progressive invasion of the meninges, skull base, orbit, and brain
    A I Holodny
    Department of Radiology, New Jersey Medical School, University Hospital, 150 Bergen Street, Newark, NJ 07103, USA
    AJNR Am J Neuroradiol 22:876-9. 2001
    ..fibroinflammatory lesion that originated in the left side of the neck and progressed over 2 years to involve the meninges, the cavernous sinuses, the right temporal lobe, and the right orbit...
  51. ncbi Intracranial meningeal disease: comparison of contrast-enhanced MR imaging with fluid-attenuated inversion recovery and fat-suppressed T1-weighted sequences
    Waneerat Galassi
    Department of Radiology, University of California, San Diego, Medical Center, San Diego, California 92103 8756, USA
    AJNR Am J Neuroradiol 26:553-9. 2005
    ..The purpose of this study was to compare contrast-enhanced T1-weighted MR images with fat suppression to contrast-enhanced FLAIR images to determine which sequence was superior for depicting meningeal disease...
  52. doi Expression of transforming growth factor-beta receptors in meningeal fibroblasts of the injured mouse brain
    Yukari Komuta
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo, 183 8526, Japan
    Cell Mol Neurobiol 30:101-11. 2010
    ..After 5 days postinjury, many fibroblasts migrated from the meninges to the lesion site formed the fibrotic scar, and most of them expressed TGF-beta receptors...
  53. pmc Olfactory nerve--a novel invasion route of Neisseria meningitidis to reach the meninges
    Hong Sjölinder
    Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm, Sweden
    PLoS ONE 5:e14034. 2010
    ..epithelium, along olfactory nerves in the cribriform plate, at the olfactory bulb and subsequently at the meninges and subarachnoid space...
  54. pmc EphA4 deficient mice maintain astroglial-fibrotic scar formation after spinal cord injury
    Julia E Herrmann
    Department of Neurosciences, University of California San Diego, School of Medicine, 9500 Gilman Drive, MC 0691, La Jolla, CA 92093 0691, USA
    Exp Neurol 223:582-98. 2010
    ..In contrast to what has been proposed, these data do not support a major role for EphA4 in reactive astrogliosis following SCI...
  55. doi An in vitro model of the inhibition of axon growth in the lesion scar formed after central nervous system injury
    Junko Kimura-Kuroda
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Tokyo, Japan
    Mol Cell Neurosci 43:177-87. 2010
    ..Therefore, this culture system can be available to analyze the inhibitory property in the lesion site of CNS...
  56. pmc Regulation of radial glial survival by signals from the meninges
    Randor Radakovits
    The Scripps Research Institute, Department of Cell Biology, Institute for Childhood and Neglected Disease, La Jolla, California 92037, USA
    J Neurosci 29:7694-705. 2009
    ..Apoptosis is also induced by surgical removal of the meninges. Finally, mice lacking the BM components laminin alpha2 and alpha4 show defects in the attachment of RGC ..
  57. ncbi The microvasculature of the human cerebellar meninges
    Hiroko Nonaka
    Department of Pathology, Toho University School of Medicine, 5 21 16 Ohmori nishi, Ohtaku, Tokyo 143 8540, Japan
    Acta Neuropathol 104:608-14. 2002
    The vascular architecture of the human cerebellar meninges was investigated. The surface meninges were poor in vasculature. In the sulci, the meninges were highly vascular but had few capillaries...
  58. ncbi A novel immune-to-CNS communication pathway: cells of the meninges surrounding the spinal cord CSF space produce proinflammatory cytokines in response to an inflammatory stimulus
    Julie Wieseler-Frank
    Department of Psychology, University of Colorado, Boulder, CO, USA
    Brain Behav Immun 21:711-8. 2007
    ..spinal cord glia are the sole source of CSF cytokines may be an underestimate, as the cellular composition of the meninges surrounding the spinal cord CSF space includes several cell types known to produce proinflammatory cytokines...
  59. ncbi Secreted proteins from Neisseria meningitidis mediate differential human gene expression and immune activation
    Karen Robinson
    Molecular Bacteriology and Immunology Group, Division of Microbiology and Infectious Diseases, University Hospital, Nottingham, NG7 2UH, UK
    Cell Microbiol 6:927-38. 2004
    ..Secreted meningococcal virulence factors are therefore important in inducing host inflammatory responses and resistance to apoptosis, and they are worthy of extensive investigation...
  60. ncbi Intrathecal epidermal growth factor and fibroblast growth factor-2 exacerbate meningeal proliferative lesions associated with intrathecal catheters
    Ann M Parr
    Neurosurgery 60:926-33; discussion 926-33. 2007
    ..We studied this proliferation in a minimal injury rat model in the presence of epidermal growth factor and fibroblast growth factor-2...
  61. ncbi Morphological changes of the retrobulbar optic nerve and its meningeal sheaths in glaucoma
    Mona Pache
    University Eye Clinic Freiburg, Freiburg, Germany
    Ophthalmologica 220:393-6. 2006
    ..Occurrence and amount of meningo- thelial cell nests in the subarachnoid space were however significantly increased in glaucoma (p < 0.02). Whether this observation is glaucoma specific deserves further investigation...
  62. ncbi The astrocyte/meningeal cell interface--a barrier to successful nerve regeneration?
    M C Shearer
    Department of Physiology, University of Cambridge, England
    Cell Tissue Res 305:267-73. 2001
    ..The distribution of cell surface and matrix molecules on these cultures is described, and the effect of various pharmacological interventions which can affect axon growth between the two cell types is summarised in this review...
  63. ncbi Leptomeningeal disease from oligodendroglioma: clinical and molecular analysis
    Gloria Roldan
    Department of Oncology, Tom Baker Cancer Centre, Alberta Cancer Board, University of Calgary, Calgary, Alberta Canada
    Can J Neurol Sci 35:204-9. 2008
    ..A long surviving case led us to review our experience with LMD in patients with oligodendrogliomas...
  64. doi Expression of nestin, mesothelin and epithelial membrane antigen (EMA) in developing and adult human meninges and meningiomas
    Josko Petricevic
    Department of Pathology, Cytology and Forensic Medicine, University Clinical Hospital Mostar, Bosnia and Herzegovina
    Acta Histochem 113:703-11. 2011
    ..and mesothelin proteins was immunohistochemically determined in the cells of normal developing and adult human meninges and meningiomas. Human meninges developed as two mesenchymal condensations in the head region...
  65. doi Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells
    Lars Ove Brandenburg
    Department of Anatomy and Cell Biology, RWTH Aachen University, Germany
    J Neuroimmunol 217:55-64. 2009
    Bacterial meningitis is characterized by an inflammation of the meninges and continues to be an important cause of mortality and morbidity...
  66. ncbi Meningeal cells enhance limited CNS remyelination by transplanted olfactory ensheathing cells
    Andras Lakatos
    Department of Clinical Veterinary Medicine, University of Cambridge, UK
    Brain 126:598-609. 2003
    ..These results highlight the important concept that the regenerative properties of OECs are profoundly influenced by the cells with which they are transplanted...
  67. doi Substantial archaeocortical atrophy and neuronal loss in multiple sclerosis
    Dimitrios Papadopoulos
    Department of Cellular and Molecular Neuroscience, Imperial College Faculty of Medicine, Imperial College London, Hammersmith Hospital Campus, London, UK
    Brain Pathol 19:238-53. 2009
    ..Our study provides evidence of substantial archaeocortical pathology largely resembling patterns seen in the neocortex and suggests that hippocampal involvement could contribute to memory impairments often seen in MS...
  68. pmc CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges
    K Nozaki
    Stroke Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston 02114
    Br J Pharmacol 106:409-15. 1992
    ..Bacterial, viral(including AIDS meningovascular inflammation) and other forms of chemical meningitis merit further investigation...
  69. ncbi The astrocyte/meningeal cell interface is a barrier to neurite outgrowth which can be overcome by manipulation of inhibitory molecules or axonal signalling pathways
    Morven C Shearer
    Department of Physiology and Cambridge Centre for Brain Repair, University of Cambridge, Cambridge CB2 3EG, England, UK
    Mol Cell Neurosci 24:913-25. 2003
    ..Increasing cAMP levels and inactivation of rho were both effective when the cultures were fixed in paraformaldehyde, demonstrating that their effect is on axons and not via effects on the glial cells...
  70. doi Anatomy and development of the meninges: implications for subdural collections and CSF circulation
    Julie Mack
    Department of Radiology, Penn State Hershey Medical Center, 30 Hope Drive, Suite 1800, P O Box 859, Hershey, PA, 17033 0859, USA
    Pediatr Radiol 39:200-10. 2009
    ..This review outlines the development and age-specific vascularity of the dura and offers an alternative perspective on the role of the dura in homeostasis of the central nervous system...
  71. ncbi Histological evidence for drug diffusion across the cerebral meninges into the underlying neocortex in rats
    Nandor Ludvig
    NYU Comprehensive Epilepsy Center, Department of Neurology, NYU School of Medicine, New York, NY 10016, USA
    Brain Res 1188:228-32. 2008
    ..the extent to which a marker compound, N-methyl-D-aspartate (NMDA), can diffuse into the neocortex through the meninges. Rats were implanted with bilateral parietal cortical epidural cups filled with 50 mM NMDA on the right side and ..
  72. pmc Induction of the antimicrobial peptide CRAMP in the blood-brain barrier and meninges after meningococcal infection
    Peter Bergman
    Department of Medical Biochemistry and Biophysics, Scheeles vag 2, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Infect Immun 74:6982-91. 2006
    ..rarely infected, which has mainly been ascribed to the protective functions of the blood-brain barrier (BBB) and meninges. Since the bactericidal properties of the BBB and meninges are not known, we hypothesized that antimicrobial ..
  73. ncbi Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I
    E Kakkis
    Division of Medical Genetics, Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance CA, USA
    Mol Genet Metab 83:163-74. 2004
    ..whether intrathecal (IT) recombinant human alpha-L-iduronidase (rhIDU) could penetrate and treat the brain and meninges. An initial dose-response study showed that doses of 0.46-4...
  74. ncbi Patterns of contrast enhancement in the brain and meninges
    James G Smirniotopoulos
    Department of Radiology and Radiological Sciences, Uniformed Services University, Bethesda, MD 20813, USA
    Radiographics 27:525-51. 2007
    ..Understanding the classic patterns of lesion enhancement--and the radiologic-pathologic mechanisms that produce them--can improve image assessment and differential diagnosis...
  75. pmc Label-free in vivo optical imaging of functional microcirculations within meninges and cortex in mice
    Yali Jia
    Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR 97239, USA
    J Neurosci Methods 194:108-15. 2010
    Abnormal microcirculation within meninges is common in many neurological diseases. There is a need for an imaging method that is capable of monitoring dynamic meningeal microcirculations, preferably decoupled from cortical blood flow...
  76. ncbi Parasellar solitary fibrous tumor of meninges: magnetic resonance imaging features with pathologic correlation
    Chung Ping Lo
    Department of Radiology, Tri Service General Hospital and National Defense Medical Center, Taipei, Taiwan, ROC
    J Neuroimaging 14:281-4. 2004
    ..The authors report the case of a 50-year-old man with SFT arising from the meninges of the left parasellar region with cavernous sinus involvement...
  77. ncbi FLAIR MR imaging for diagnosing intracranial meningeal carcinomatosis
    K Tsuchiya
    Department of Radiology, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka, Tokyo 181-8611, Japan
    AJR Am J Roentgenol 176:1585-8. 2001
    ..Contrast-enhanced FLAIR images can sometimes surpass contrast-enhanced T1-weighted images in their quality...
  78. pmc HIV-1 phylogenetic analysis shows HIV-1 transits through the meninges to brain and peripheral tissues
    Susanna L Lamers
    Polytechnic Institute of New York University, Brooklyn, NY, USA
    Infect Genet Evol 11:31-7. 2011
    ..Interestingly, the major tissue harboring virus from both the brain and peripheral tissues was the meninges. These results show that (1) HIV-1 is clearly capable of migrating out of the brain, (2) the meninges are the ..
  79. ncbi Prevalence of psammoma bodies in meninges and choroid plexuses of raccoons (Procyon lotor) from Parramore Island, Virginia
    A N Hamir
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, PA 19348, USA
    J Vet Diagn Invest 13:76-9. 2001
    ..Most mineralized foci had concentric laminations and were present in small capillaries of meninges of the brain (15/33), in choroid plexus (3/33), or at both these sites (13/33)...
  80. ncbi The meninges is a source of retinoic acid for the late-developing hindbrain
    Jinghua Zhang
    E Kennedy Shriver Center, University of Massachusetts Medical School, University of Massachusetts, Waltham, Massachusetts 02452, USA
    J Neurosci 23:7610-20. 2003
    ..the hindbrain from the RA synthetic enzyme retinaldehyde dehydrogenase-2 (RALDH2) present in the surrounding meninges and mesenchyme by embryonic day 13...
  81. doi Meningeal cells induce dopaminergic neurons from embryonic stem cells
    Hideki Hayashi
    Department of Biological Repair, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan
    Eur J Neurosci 27:261-8. 2008
    ..These results indicate that meningeal cells can be used as feeders to induce DA neurons from ES cells, and that Wnt-5a plays an important role in DA neuron induction by SDIA...
  82. ncbi Extranodal Rosai-Dorfman disease involving the meninges
    Carlos Franco-Paredes
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    South Med J 95:1101-2. 2002
    ..Meningeal biopsy revealed Rosai-Dorfman disease. Sinus histiocytosis may mimic meningeal disease, and Rosai-Dorfman disease should be considered in the differential diagnosis of dural-based masses with diffuse leptomeningeal enhancement...
  83. ncbi Maternalizing the meninges: a pregnant Arabic legacy
    Manu Kothari
    Neurol India 54:345-6. 2006
  84. ncbi Microvasculature of the human cerebral meninges
    Hiroko Nonaka
    Department of Pathology, Toho University School of Medicine, Ohta ku, Tokyo, Japan
    Neuropathology 23:129-35. 2003
    In the present study, the human cerebral meninges were rich in blood vessels, but no capillaries were noted. The meningeal arteries ran over the veins where they crossed. Several arterial anastomoses existed on the cortical surface...
  85. ncbi Lymphatic drainage of the cerebrospinal fluid from monkey spinal meninges with special reference to the distribution of the epidural lymphatics
    M Miura
    Department of Anatomy, Oita Medical University, Japan
    Arch Histol Cytol 61:277-86. 1998
    ..structural organization of the epidural lymphatics and lymphatic drainage of the cerebrospinal fluid from spinal meninges was studied in Japanese monkeys (Macaca fuscata) by an enzyme-histochemical method...
  86. ncbi [What is your diagnosis?]
    R Tanasescu
    Service de Neurologie, CHU Nancy, France
    J Neuroradiol 31:397-8. 2004
  87. ncbi Lateral transsulcal approach to asymptomatic trigonal meningiomas with correlative microsurgical anatomy: technical case report
    Shinji Nagata
    Department of Neurosurgery, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Neurosurgery 56:E438; discussion E438. 2005
    ..We introduce the lateral transsulcal approach to asymptomatic trigonal meningiomas...
  88. ncbi Subacute aseptic meningitis as neurological manifestation of primary Sjögren's syndrome
    Rosario Rossi
    Unit of Neurology, San Francesco Hospital, via Mannironi, 08100 Nuoro, Italy
    Clin Neurol Neurosurg 108:688-91. 2006
    ....
  89. ncbi Herpes simplex encephalitis
    Sean W Taylor
    Department of Medicine Neurology, Queen s University, Kingston, Ontario, Canada
    Can J Neurol Sci 32:246-7. 2005
  90. ncbi CNS myelomatosis
    Vitalie D Lupu
    EMG Section, National Institute of Neurologic Disorders and Stroke, NIH, Bldg 10, Room 5C101, 10 Center Drive MSC 1404, Bethesda, MD 20892 1404, USA
    Neurology 64:1007. 2005
  91. ncbi Ribosome-lamella complex in aggressive solitary fibrous tumour of the meninges
    David Scheie
    Acta Neuropathol 110:312-4. 2005
  92. ncbi Delayed occurrence of intracranial supratentorial chondroma following compound depressed skull fracture
    J T Hong
    Department of Neurosurgery, St Vincent Hospital, The Catholic University of Korea, Chi dong, Paldal Ku, Suwon, Korea
    Acta Neurochir (Wien) 147:343-5; discussion 345. 2005
    ....
  93. ncbi Incidentally detected parafalcine chondrosarcoma
    M Tosaka
    Department of Neurosurgery, Gunma University Graduate School of Medicine, Gunma, Japan
    Acta Neurochir (Wien) 147:795-9; discussion 799. 2005
    ..SPECT using (201)TlCl and (123)I-IMP may be useful to discriminate parafalcine low-grade chondrosarcoma from meningioma or other tumours originating in this region...
  94. doi Meningeal dissemination in primary CNS lymphoma: prospective evaluation of 282 patients
    L Fischer
    Department of Hematology, Oncology and Transfusion Medicine, Charite Campus Benjamin Franklin, Berlin, Germany
    Neurology 71:1102-8. 2008
    ..We prospectively evaluated the diagnostic value of PCR in comparison with CSF cytomorphology and MRI for diagnosing meningeal dissemination in PCNSL...
  95. ncbi Anterior cranial base glioneuronal heterotopia
    Dattatraya Muzumdar
    Division of Neurosurgery, Children s Hospital of Eastern Ontario, Ottawa, Ontario, Canada
    Childs Nerv Syst 22:227-33. 2006
    Cranial base glioneuronal heterotopia is a nest or linear array of glioneuronal tissue within the basal meninges. It is thought to arise from aberrant migration of embryonic neuroepithelial tissues into the subarachnoid space...
  96. ncbi [Spinal and cerebral leptomeningeal seeding from a melanocytoma of the cerebello-pontine angle]
    Horst J Koch
    Neurologische Universitätsklinik Regensburg, Deutschland
    Wien Med Wochenschr 155:360-4. 2005
    ..This tumor did not respond to a combined radiochemotherapy including oral temozolomide, and the patient died 5 months after starting treatment for this relapse. Secondary malignisation of the melancytoma is suggested...
  97. ncbi Low cerebrospinal fluid pressure syndromes
    Bahram Mokri
    Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Neurol Clin 22:55-74, vi. 2004
    ..Some of the older concepts or presumptions have been challenged while novel observations continue to appear in the literature. We are still in the learning phase...
  98. doi Growth rate of non-operated meningiomas
    L A Zeidman
    Dept of Neurology, Northwestern University, 710 N Lake Shore Drive, Abbott Hall, 1115, Chicago, IL 60611, USA
    J Neurol 255:891-5. 2008
    ..Some meningiomas grow slowly or seemingly not at all with planimetric measurement. Volumetric measurement may be more accurate because tumors may grow in different directions than the planimetric axes...
  99. ncbi [Cerebral amyloid angiopathy]
    Florian Laly
    Groupe hospitalier Joffre Dupuytren, Draveil
    Psychol Neuropsychiatr Vieil 5:35-45. 2007
    ..Recent progresses in the field of MRI make the diagnosis of cerebral amyloid angiopathy easier and more accurate. MRI should be more frequently performed in aged patients...
  100. ncbi [Sinonasal and cerebral imaging findings in Wegener's granulomatosis]
    Stephane Silvera
    Service de Radiologie A, Hopital Cochin, Paris, France
    Presse Med 36:913-21. 2007
    ..These imaging findings of Wegener's granulomatosis are nonspecific. They should be combined with clinical examination and c-ANCA tests to confirm the diagnosis...
  101. ncbi A case of sarcoidosis presenting as a non-specific intramedullary lesion
    D Caneparo
    Section of Neurology, Department of Neuroscience, University of Pisa, Pisa, Italy
    Eur J Neurol 14:346-9. 2007
    ....

Research Grants74

  1. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..rate will be analyzed by ANCOVA and multiple range and tested for associations with alterations (brain and meninges) in Ap fragments, LRP-1 and RAGE...
  2. Role of TRP Channels in Environmental Irritant-Induced Headache
    Gerry S Oxford; Fiscal Year: 2013
    ..that chemical activation of TRPA1 homomers, or TRPA1/TRPV1 heteromers on trigeminal neurons innervating the meninges results in release of calcitonin gene-related peptide (CGRP), a potent vasodilator implicated in migraine...
  3. PHENOGENETICS OF SKULL AND BRAIN INTEGRATION IN CRANIOSYNOSTOSIS
    JOAN THERESE RICHTSMEIER; Fiscal Year: 2012
    ..Importantly, FGFRs are involved in development of the skull, meninges, and the brain...
  4. Induction of DNA Damage Signaling Cascade upon RVFV Infection
    Kylene Kehn-Hall; Fiscal Year: 2013
    ..In humans, RVFV infection causes inflammation of the brain, spinal cord, and meninges, retinitis with visual impairments, and liver necrosis with hemorrhaging...
  5. Mast cell actions in chronic progressive versus relapsing remitting EAE
    JULIANNE K HATFIELD; Fiscal Year: 2013
    ..The primary site of mast cell action is the meninges, where they regulate BBB permeability and cellular accumulation in the CNS which is associated with neutrophil ..
  6. DEFECTIVE FOREBRAIN DEVELOPMENT IN MUTANT MICE
    SAMUEL JEREMY PLEASURE; Fiscal Year: 2013
    ..generate the basement membrane (BM) covering the cortex, and it has long been known that destruction of the meninges or the BM has substantial consequences for cortical development...
  7. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2013
    ..of a CGRP antagonist to a mouse model of neurogenic migraine will attenuate both plasma extravasation in the meninges and the inner ear and central c-Fos expression in trigeminal and vestibular pathways...
  8. The Role of ASICs in Migraine Pathophysiology
    Gregory O Dussor; Fiscal Year: 2013
    ..Prior preclinical work has found that trigeminal pain-sensing neurons (nociceptors) innervating the cranial meninges (i.e. the dura mater) are sensitive to substances released from mast cells...
  9. Spinal Neuroimmune Mechanisms Underlying IL-10 Gene Therapy for Pain Control
    Erin D Milligan; Fiscal Year: 2013
    ..microglia, Satellite &Schwann) in pain relevant compartments such as the spinal cord dorsal horn, spinal meninges associated subarachnoid matrix, &dorsal root ganglia...
  10. Immune cell dynamics during central nervous system viral infection
    Juan C de la Torre; Fiscal Year: 2010
    ..The dynamics of cellular interactions in the meninges during failed or effective control of infection have not been studied previously...
  11. Meninges-to-astrocyte communication in cognitive function
    Jonathan Kipnis; Fiscal Year: 2013
    ..that recruited T cells regulate meningeal myeloid cell phenotype and thus define the cytokine composition of the meninges. These cytokines, in turn, influence cognition either directly or through astrocyte-mediated synaptogenesis, ..
  12. Discovering a Combination Therapeutic Approach to Use in the Treatment of Cryptoc
    Mitchell W Mutz; Fiscal Year: 2013
    ..CM presents with symptoms including severe nausea, headache due to inflammation of the meninges, altered mental status, and fever...
  13. Understand the Role of Meningeal Dendritic Cells in CNS Anti-viral Immunity
    Kang Liu; Fiscal Year: 2013
    ..studies indicate that Treg entry into the infected CNS appears to be regulated by a population of DCs in the meninges, which we recently identified...
  14. HSV-1-specific T-cell responses in human sensory ganglia
    David M Koelle; Fiscal Year: 2010
    ..within neurons in sensory ganglia, particularly the trigeminal ganglia (TG) that enervate that face, cornea, and meninges. Animal models of HSV-1 infection have recently proven that the TG is an immunocompetent organ with regard to the ..
  15. Rodent Behavioral Model of Ongoing Headache Pain
    ANDREW MARK STRASSMAN; Fiscal Year: 2013
    ..the idea that migraine and other headaches result from the activation of the sensory nerves that end in the meninges. Consequently, experimentally induced activation of these meningeal nerve endings has been used to investigate ..
  16. REGIONAL DIFFERENTIATION DURING FOREBRAIN DEVELOPMENT
    Anthony S LaMantia; Fiscal Year: 2010
    ..At early stages the FnM produces RA that acts on subsets of forebrain precursors. Subsequently, the meninges synthesize RA that acts on forebrain progenitors...
  17. Mechanisms by which effector T cells modulate endogenous remyelination
    Peter A Calabresi; Fiscal Year: 2013
    ..Lymphoid follicles within the meninges and compartmentalized inflammation may be a major effector population for grey matter injury and incomplete ..
  18. Macromolecular therapeutics for neoplastic meningitis
    Mikhail I Papisov; Fiscal Year: 2011
    ..therapeutics that would distribute in CSF and release an insoluble antineoplastic drug that would (I) stay in the meninges and (II) readily access the meningeal population of cancer cells...
  19. In Vivo Measurement of Brain Biomechanics
    Philip V Bayly; Fiscal Year: 2013
    ..In Aim 1 we will address the question: What are the roles of tethering and supporting structures (vessels and meninges) in the brain's response to skull acceleration? In Aim 2, we ask how these structures, as well as residual ..
  20. MODULATORY ROLE OF GABA AND 5HT RECEPTORS IN MIGRAINE
    F Cutrer; Fiscal Year: 1999
    ..to determine whether these subtypes are expressed on trigeminal ganglia and trigeminal axons projecting to the meninges and/or on meningeal blood vessels...
  21. Meningeal Mast Cells: Key effectors of stroke pathology
    Gary K Steinberg; Fiscal Year: 2013
    ..Our overall hypothesis is that mast cells residing in the meninges are key effectors of stroke pathology. This is tested in Aim 1 using two different approaches...
  22. Tissue injury and inflammation in MS (P50)
    Bruce D Trapp; Fiscal Year: 2013
    ..This project will also address mechanisms of selective leukocyte trafficking to meninges and cortex...
  23. Congenital brain malformations caused by aberrant head mesenchymal signaling
    KATHLEEN JOYCE MILLEN; Fiscal Year: 2013
    ..The recognition that the meninges is a critical regulator of CNS development is a recent paradigm shift in the field of neurodevelopment and the ..
  24. Forebrain angiogenesis in Foxc1 mutant mice
    Julie Siegenthaler; Fiscal Year: 2013
    ..One goal of this grant is to determine how absence of the meninges and defects in neocortical development differentially contribute to vascular malformations in Fox1 mutant mice...
  25. Pathogenesis of Lyme Borreliosis in the Rhesus Monkey
    MARIO PHILIPP; Fiscal Year: 2007
    ..Archival samples of B. burgdorferi-infected rhesus meninges and brain parenchyma will be assessed for presence of inflammatory infiltrate (meninges), association of similar ..
  26. Role of Fibroblasts in Axon Regeneration after SCI
    Jae K Lee; Fiscal Year: 2013
    ..While the meninges were thought to be the primary source of fibroblasts after SCI, recent evidence indicates that the perivascular ..
  27. Genetic Analysis of Mammalian CNS Development
    E Crenshaw; Fiscal Year: 2004
    ..To further characterize the role of BMP signaling in meninges and choroid plexus development...
  28. TRIGGERING MECHANISMS FOR MIGRANINE HEADACHE
    MOSKOWITZ MICHAEL; Fiscal Year: 2006
    ..intrinsic brain parencymal event underlying migraine visual aura initiates a cascade of events in the overlying meninges consistent with trigeminovascular activation and compatible with lateralized head pain...
  29. Translational Profile of Perivascular Fibroblasts after Spinal Cord Injury
    Jae K Lee; Fiscal Year: 2013
    ..While the meninges were thought to be the primary source of fibroblasts after SCI, recent evidence indicates that the perivascular ..
  30. A novel yeast vaccine against Coccidioides Immitis
    Claude Selitrennikoff; Fiscal Year: 2003
    ..However, in a significant number of cases, chronic pulmonary conditions or dissemination to the meninges, bones, and joints can result, leading to acute, life-threatening disease. Migrant laborers who are exposed to C...
  31. Intrathecal Cancer Therapy using I131 NaI
    Franklin Wong; Fiscal Year: 2002
    ..to the underlying nervous tissues while the latter, by intrathecal breakdown and poor penetration of the meninges to reach the tumors...
  32. EFFECT OF PORA ON MENINGOCOCCI-MACROPHAGE INTERACTION
    Lillian Waldbeser; Fiscal Year: 1999
    ..the bloodstream from the nasopharynx and from there crosses the blood brain barrier to cause inflammation of the meninges. Before the organism reaches the central nervous system, it would have encountered numerous phagocytic cells, ..
  33. Intralumbar Injection for Cancer Therapy using I-131 Nal
    Franklin Wong; Fiscal Year: 2004
    Current intrathecal chemotherapy against leptomeningeal metastasis (LM) is limited by slow diffusion through the meninges to reach the tumor deposits. Neural-axis radiotherapy is limited by radiotoxicity to the underlying neural tissues...
  34. Retinoic Acid in the Developing Visual Pathway
    URSULA DRAGER; Fiscal Year: 2005
    ..restricted sources of RALDH expression: the eye and face, the ganglionic eminence, the optic axons, and the meninges. RA responses will be detected in a transgenic mouse strain whose tissues respond to RA with expression of a ..
  35. Viral/Cell Determinants of HIV Drug Resistance in CNS
    Suzanne Gartner; Fiscal Year: 2007
    ..HIV genome from post- mortem bone marrow and lymph node tissues, along with multiple regions of brain, including meninges and choroid plexus, collected from patients treated with multiple antiretrovirals...
  36. HIV Sequence Evolution in AIDS Dementia Pathogenesis
    Michael McGrath; Fiscal Year: 2009
    ..studies we found that an original/earliest form of HIV gp120-V3 sequence in a patient with HAD was in the meninges. This sequence was clearly the origin of all of the other sequences evaluated, including those in four other ..
  37. CONTRIBUTIONS OF CHOROID PLEXUS TO HIV NEUROPATHOGENESIS
    Suzanne Gartner; Fiscal Year: 2002
    ..Specifically, the proposal investigates the contribution of the choroid plexus (CP) and meninges. The Aims of the proposal are 1). To determine if the CP is a source of HIV in CSF; 2)...
  38. CNS MALDEVELOPMENT AND PERINANTAL INFECTION
    William Britt; Fiscal Year: 2007
    ..in these animals appears to require both virus replication in the brain and an inflammatory infiltrate in the meninges and parenchyma...
  39. Mast Cells: Role in the Pathophysiology of Headache
    Dan Levy; Fiscal Year: 2007
    ..result from the activation of primary afferent nociceptive neurons innervating intracranial blood vessels and the meninges. Endogenous factors underlying this neuronal activation remain poorly understood...
  40. NEUROBIOLOGY OF ANOREXIA INDUCED BY MIGRAINE PAIN
    Rami Burstein; Fiscal Year: 2004
    ..abstract_text> ..
  41. Migraine Pathophysiology:Thalamus and Extended Allodynia
    Rami Burstein; Fiscal Year: 2009
    ....
  42. Pilot/Phase I Study of Intrathecal Laronidase for Spinal Cord Compression in Muco
    Patricia Dickson; Fiscal Year: 2009
    ..If successful, delivery into the spinal fluid could represent a practical, straightforward method of treating central nervous system disease due to lysosomal storage. ..
  43. Intrathecal enzyme therapy for mucopolysaccharidosis I
    Patricia I Dickson; Fiscal Year: 2010
    ..This research investigates intrathecal enzyme therapy for canine MRS I with translation to the first clinical trial of intrathecal enzyme replacement therapy for MRS I patients. ..
  44. CD8 T Lymphocyte Regulation of EAE Disease Phenotype
    Michael Carrithers; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  45. NABTT-Consortium Therapeutic Studies of CNS Malignancies
    Stuart Grossman; Fiscal Year: 2008
    ..abstract_text> ..
  46. NEUROBIOLOGY OF PAIN
    Tony Yaksh; Fiscal Year: 2005
    ..The complexity of the problems and the diversity of the training approaches emphasize that the training received by these fellows will provide a broad base of knowledge relevant to wide areas of neurobiology. ..
  47. Lapatinib in childhood CNS malignancies
    Maryam Fouladi; Fiscal Year: 2006
    ..These data will be used in the rational design of future phase I combination or frontline studies to improve the outcome in children with these poor prognosis tumors. [unreadable] [unreadable]..
  48. Training Program in Neurovirology
    HOWARD GENDELMAN; Fiscal Year: 2006
    ....
  49. NEURONAL ELECTROPHYSIOLOGY IN HIV DEMENTIA
    HOWARD GENDELMAN; Fiscal Year: 2001
    ....
  50. Genetics of Neuropathogenic SIV Infection
    Francis Novembre; Fiscal Year: 2007
    ..Finally, we will investigate the evolution of the ability of these viruses to induce the production of neurotoxins in CNS derived cells. ..
  51. NEUROPHYSIOLOGY OF CRANIAL HEADACHE
    Andrew Strassman; Fiscal Year: 2008
    ..of migraine are thought to result from activation or sensitization of sensory nerve fibers in the intracranial meninges. Neurons in the meningeal sensory pathway have been the subject of numerous neurophysiological studies...
  52. HIV Neurocognitive Disorders: A Randomized Clinical Trial of CNS-Targeted HAART
    Ronald J Ellis; Fiscal Year: 2010
    ..The proposed clinical trial would provide the level of evidence needed to formulate ART guidelines specific to HNCI. ..
  53. Extra-pulmonary pathology caused by avian H5N1 and recombinant H1N1-1918 influenz
    Helle Bielefeldt Ohmann; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  54. Biological Role of the FE65 Protein/APP Interactions
    Suzanne Guenette; Fiscal Year: 2009
    ..In addition, we will gain insight into the role of the FE65 proteins in cellular signaling events that are critical for brain function. ..
  55. Brain serotonin and angiotensin II systems in migraine
    JOSE TERRON; Fiscal Year: 2007
    ..5-HT content will be measured by HPLC in brain homogenates. ..
  56. E. coli invasion of brain endothelial cells
    Kwang Kim; Fiscal Year: 2008
    ..coli meningitis, which mimics human E. coli meningitis (e.g., hematogenous infection of the meninges). Using these in vitro and in vivo systems, we have shown that E...
  57. NEURONAL MIGRATION IN THE DEVELOPING BRAIN
    Huaiyu Hu; Fiscal Year: 2003
    ....
  58. Molecular Mechanisms of Estrogen Neuroprotection
    Michael Wang; Fiscal Year: 2005
    ..The mechanism of how estrogen affects stroke will perhaps foster development of novel treatments for stroke, and may influence hormone replacement regimens for postmenopausal women. ..
  59. Pain Mechanisms and the Development of Analgesics
    Tony Yaksh; Fiscal Year: 2006
    ..g. COX2 inhibitors, GABApentin, ziconotide) and failures (NK1 antagonist). [unreadable] [unreadable] [unreadable]..
  60. High Resolution Mapping of Pain in the Dorsal Horn
    Andrew Strassman; Fiscal Year: 2006
    ..abstract_text> ..
  61. HIV Clade on Cognitive and Neurological Disorders Brazil
    Ronald Ellis; Fiscal Year: 2007
    ..UCSD investigators will train and guide the administration and interpretation of the clinical assessment instruments, transfer technology to the Brazilian site. [unreadable] [unreadable]..
  62. Participating Member Institution in NABTC
    Lisa DeAngelis; Fiscal Year: 2008
    ..abstract_text> ..
  63. Molecular Studies of Brain Malformations
    Huaiyu Hu; Fiscal Year: 2007
    ....
  64. BIODEGRADABLE HYDROPHILIC POLYACETALS
    MIKHAIL PAPISOV; Fiscal Year: 2001
    ..abstract_text> ..
  65. PRODUCTION OF BETA-GLUCURONIDASE FOR MPS VII
    Emil Kakkis; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: The enzyme and process created from this work can be used to produce enzyme and treat patients suffering from Mucopolysaccharidosis VII, a serious, life-threatening genetic disorder. ..
  66. EXPERIMENTAL PATHOLOGY SHARED RESOURCE LABORATORY
    Laura Lamps; Fiscal Year: 2003
    ..abstract_text> ..
  67. THE CNS AS A VIRAL RESERVOIR IN SIV INFECTED MACAQUES
    SHAWN O NEIL; Fiscal Year: 2002
    ..abstract_text> ..
  68. Ethanol, Tat and the Blood-brain barrier
    Kwang Kim; Fiscal Year: 2004
    ..e., nitric oxide and signaling pathways. The information derived from this proposal should enhance our understanding of the role of ethanol in HIV-1 neuropthogenesis. ..
  69. Genome-wide screening of E. coli for bacteremia
    Kwang Kim; Fiscal Year: 2007
    ..coli bacteremia should help in development of preventive measures such as vaccines against E. coli bacteremia. [unreadable] [unreadable] [unreadable]..
  70. Spinal Galanin and its Receptors in Pain Processing
    Tony Yaksh; Fiscal Year: 2005
    ..We believe the outcome of these studies will provide direct evidence for the role played by this spinal peptidergic system in pain and point to the development of novel anti-hyperpathic agents. ..
  71. SYSTEMIC LYMPH NODE SPECIFIC AGENTS
    MIKHAIL PAPISOV; Fiscal Year: 2003
    ..If successful, this project will result in the development of a new class of preparations and a new strategy for prophylactic and early post-exposure treatment of bacterial diseases of Category A. ..
  72. Characterization of Toxicity with Spinal Opiates
    Tony L Yaksh; Fiscal Year: 2010
    ..The present studies aim to define the mechanisms of granuloma formation and point to specific methods to prevent granuloma formation, which will increase the utility and reduce the risks of this important pain therapy. ..
  73. Diffusion Tensor Imaging of White Matter Change in AD
    David Salat; Fiscal Year: 2008
    ..Thus, the proposed integrated training and research program could lead to novel insights about the unique contribution of WM degeneration to the clinical sequel of AD. ..
  74. Circadian and Aminergic Regulation of Orexin Neurons
    THOMAS SCAMMELL; Fiscal Year: 2005
    ....