corpus callosum

Summary

Summary: Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.

Top Publications

  1. ncbi Demyelination increases radial diffusivity in corpus callosum of mouse brain
    Sheng Kwei Song
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 26:132-40. 2005
  2. ncbi Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry
    Marcel Adam Just
    Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Cereb Cortex 17:951-61. 2007
  3. pmc Interhemispheric inhibition of the human motor cortex
    A Ferbert
    MRC Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, London
    J Physiol 453:525-46. 1992
  4. ncbi Topography of the human corpus callosum revisited--comprehensive fiber tractography using diffusion tensor magnetic resonance imaging
    Sabine Hofer
    Biomedizinische NMR Forschungs GmbH am Max Planck Institut für biophysikalische Chemie, 37070 Gottingen, Germany
    Neuroimage 32:989-94. 2006
  5. pmc Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study
    Andrea P Jackowski
    Child Study Center, Yale University School of Medicine, New Haven, CT, United States
    Psychiatry Res 162:256-61. 2008
  6. pmc Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C
    Mathieu Niquille
    Department of Cellular Biology and Morphology, University of Lausanne, Switzerland
    PLoS Biol 7:e1000230. 2009
  7. ncbi Diffusion tensor imaging of the corpus callosum in Autism
    Andrew L Alexander
    Department of Medical Physics, University of Wisconsin, Madison, WI, USA
    Neuroimage 34:61-73. 2007
  8. pmc Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 49:2995-3004. 2010
  9. ncbi In vivo quantification of global connectivity in the human corpus callosum
    Kevin Jarbo
    Learning Research and Development Center, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 59:1988-96. 2012
  10. ncbi Age-related alterations in white matter microstructure measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 26:1215-27. 2005

Detail Information

Publications353 found, 100 shown here

  1. ncbi Demyelination increases radial diffusivity in corpus callosum of mouse brain
    Sheng Kwei Song
    Department of Radiology, Biomedical MR Laboratory, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 26:132-40. 2005
    ..current study uses the well-characterized cuprizone model of experimental demyelination and remyelination of corpus callosum in mouse brain to evaluate the ability of DTI parameters to detect the progression of myelin degeneration and ..
  2. ncbi Functional and anatomical cortical underconnectivity in autism: evidence from an FMRI study of an executive function task and corpus callosum morphometry
    Marcel Adam Just
    Center for Cognitive Brain Imaging, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Cereb Cortex 17:951-61. 2007
    ..Second, relevant parts of the corpus callosum, through which many of the bilaterally activated cortical areas communicate, were smaller in cross-sectional ..
  3. pmc Interhemispheric inhibition of the human motor cortex
    A Ferbert
    MRC Human Movement and Balance Unit, National Hospital for Neurology and Neurosurgery, London
    J Physiol 453:525-46. 1992
    ..Similarly, H reflexes in relaxed forearm flexor muscles were unaffected by conditioning stimuli to the ipsilateral hemisphere. However, inhibition was observed if the experiment was repeated with the muscles active...
  4. ncbi Topography of the human corpus callosum revisited--comprehensive fiber tractography using diffusion tensor magnetic resonance imaging
    Sabine Hofer
    Biomedizinische NMR Forschungs GmbH am Max Planck Institut für biophysikalische Chemie, 37070 Gottingen, Germany
    Neuroimage 32:989-94. 2006
    ..a topographical distribution of fiber connections to the cortex in midsagittal cross-sections of the corpus callosum (CC)...
  5. pmc Corpus callosum in maltreated children with posttraumatic stress disorder: a diffusion tensor imaging study
    Andrea P Jackowski
    Child Study Center, Yale University School of Medicine, New Haven, CT, United States
    Psychiatry Res 162:256-61. 2008
    ..Multiple pediatric studies have reported reductions in the corpus callosum--the primary white matter tract in the brain...
  6. pmc Transient neuronal populations are required to guide callosal axons: a role for semaphorin 3C
    Mathieu Niquille
    Department of Cellular Biology and Morphology, University of Lausanne, Switzerland
    PLoS Biol 7:e1000230. 2009
    The corpus callosum (CC) is the main pathway responsible for interhemispheric communication...
  7. ncbi Diffusion tensor imaging of the corpus callosum in Autism
    Andrew L Alexander
    Department of Medical Physics, University of Wisconsin, Madison, WI, USA
    Neuroimage 34:61-73. 2007
    The corpus callosum is the largest commissural white matter pathway that connects the hemispheres of the human brain...
  8. pmc Altered white matter microstructure in the corpus callosum in Huntington's disease: implications for cortical "disconnection"
    H Diana Rosas
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 49:2995-3004. 2010
    The corpus callosum (CC) is the major conduit for information transfer between the cerebral hemispheres and plays an integral role in relaying sensory, motor and cognitive information between homologous cortical regions...
  9. ncbi In vivo quantification of global connectivity in the human corpus callosum
    Kevin Jarbo
    Learning Research and Development Center, Department of Psychology, University of Pittsburgh, Pittsburgh, PA, USA
    Neuroimage 59:1988-96. 2012
    ..These results illustrate the first full connectivity analysis of the human corpus callosum, revealing several patterns consistent with histological findings in the nonhuman primate.
  10. ncbi Age-related alterations in white matter microstructure measured by diffusion tensor imaging
    D H Salat
    MGH MIT HMS Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 26:1215-27. 2005
    ..were estimated from nine regions of interest in each hemisphere and from the genu and splenium of the corpus callosum (CC)...
  11. pmc In vivo measurement of axon diameter distribution in the corpus callosum of rat brain
    Daniel Barazany
    Department of Neurobiology, The George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel
    Brain 132:1210-20. 2009
    Here, we present the first in vivo non-invasive measurement of the axon diameter distribution in the rat corpus callosum. Previously, this measurement was only possible using invasive histological methods...
  12. pmc When more is less: associations between corpus callosum size and handedness lateralization
    Eileen Luders
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095 7334, USA
    Neuroimage 52:43-9. 2010
    ..To test this hypothesis, we investigated the thickness of the corpus callosum in a large data set (n=361)...
  13. ncbi Partial volume effect as a hidden covariate in DTI analyses
    Sjoerd B Vos
    Image Sciences Institute, Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroimage 55:1566-76. 2011
    ..with synthetic diffusion phantoms and analyzed bundle-specific DTI measures of the cingulum and the corpus callosum in 55 healthy subjects...
  14. pmc Development, specification, and diversity of callosal projection neurons
    Ryann M Fame
    MGH HMS Center for Nervous System Repair, Department of Neurosurgery, and Program in Neuroscience, Harvard Medical School, Boston, MA 02114, USA
    Trends Neurosci 34:41-50. 2011
    ..population of neocortical projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum. They play key roles in high-level associative connectivity, and have been implicated in cognitive syndromes ..
  15. ncbi Corpus callosum damage in heavy marijuana use: preliminary evidence from diffusion tensor tractography and tract-based spatial statistics
    D Arnone
    Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK
    Neuroimage 41:1067-74. 2008
    ..tissue combined with a white matter mapping tractography technique to investigate structural changes in the corpus callosum (CC)...
  16. pmc Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis
    N Filippini
    University of Oxford Centre for Functional Magnetic Resonance of the Brain, John Radcliffe Hospital, Oxford, UK
    Neurology 75:1645-52. 2010
    ..We sought to establish whether there is a consistent signature of cerebral white matter abnormalities in heterogeneous ALS cases...
  17. ncbi Degeneration of corpus callosum and recovery of motor function after stroke: a multimodal magnetic resonance imaging study
    Ling E Wang
    Cognitive Neurology Section, Institute of Neuroscience and Medicine INM 3, Research Centre Juelich, Germany
    Hum Brain Mapp 33:2941-56. 2012
    ..analyses revealed that diffusion MRI parameters of both the ipsilesional corticospinal tract (CST) and corpus callosum (CC) predicted increased activation of the unaffected hemisphere during movements of the stroke-affected hand...
  18. pmc The ciliogenic transcription factor RFX3 regulates early midline distribution of guidepost neurons required for corpus callosum development
    Carine Benadiba
    Departement de Biologie Cellulaire et de Morphologie, University of Lausanne, Lausanne, Switzerland
    PLoS Genet 8:e1002606. 2012
    The corpus callosum (CC) is the major commissure that bridges the cerebral hemispheres. Agenesis of the CC is associated with human ciliopathies, but the origin of this default is unclear...
  19. pmc A cascade of morphogenic signaling initiated by the meninges controls corpus callosum formation
    Youngshik Choe
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 73:698-712. 2012
    The corpus callosum is the most prominent commissural connection between the cortical hemispheres, and numerous neurodevelopmental disorders are associated with callosal agenesis...
  20. ncbi Noninvasive detection of cuprizone induced axonal damage and demyelination in the mouse corpus callosum
    Shu Wei Sun
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 55:302-8. 2006
    ..mice was a highly reproducible model of CNS white matter demyelination and remyelination affecting the corpus callosum (CC). In the present study, six C57BL/6 male mice were fed 0...
  21. ncbi Diffusion tensor imaging of the posterior cingulate is a useful biomarker of mild cognitive impairment
    Terence C Chua
    School of Psychiatry, University of New South Wales, NSW, Australia
    Am J Geriatr Psychiatry 17:602-13. 2009
    ..Biomarkers may help identify individuals at greatest risk of progressive decline. The authors examine a novel neuroimaging technique, diffusion tensor imaging (DTI) as a potential biomarker of MCI...
  22. ncbi Men and women are different: diffusion tensor imaging reveals sexual dimorphism in the microstructure of the thalamus, corpus callosum and cingulum
    K Menzler
    Philipps University Marburg, Center of Brain Imaging, Department of Neurology, Marburg, Germany
    Neuroimage 54:2557-62. 2011
    ..In the present study, we used diffusion tensor imaging (DTI) to delineate sex differences of brain white matter...
  23. ncbi Callosal contributions to simultaneous bimanual finger movements
    Laura Bonzano
    Department of Neurosciences, Ophthalmology, and Genetics, University of Genoa, 16132 Genoa, Italy
    J Neurosci 28:3227-33. 2008
    b>Corpus callosum (CC) is involved in the performance of bimanual motor tasks...
  24. ncbi When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study
    M Di Paola
    Laboratory of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Neurology 74:1136-42. 2010
    The corpus callosum (CC) has been shown to be susceptible to atrophy in Alzheimer disease (AD) as a correlate of wallerian degeneration or retrogenesis. However, when and where these 2 mechanisms intervene is still unclear.
  25. pmc Characterization of the corpus callosum in very preterm and full-term infants utilizing MRI
    Deanne K Thompson
    Howard Florey Institute, Centre for Neuroscience, University of Melbourne, Melbourne, Victoria, Australia
    Neuroimage 55:479-90. 2011
    The corpus callosum is the largest white matter tract, important for interhemispheric communication...
  26. ncbi Diffusion tensor imaging of corpus callosum integrity in multiple sclerosis: correlation with disease variables
    Tal Sigal
    Radiology Department, Sheba Medical Center, Tel Hashomer, Israel
    J Neuroimaging 22:33-7. 2012
    b>Corpus callosum (CC) is frequently involved in multiple sclerosis (MS)...
  27. pmc Corpus callosum alterations in very preterm infants: perinatal correlates and 2 year neurodevelopmental outcomes
    Deanne K Thompson
    Florey Neuroscience Institutes, Centre for Neuroscience, The University of Melbourne, Melbourne, VIC 3010, Australia
    Neuroimage 59:3571-81. 2012
    The aim of this study was to relate altered corpus callosum (CC) integrity in 106 very preterm (VPT) infants (<30 weeks' gestational age or <1250 g birth weight) at term equivalent to perinatal predictors and neurodevelopmental ..
  28. pmc Assessing corpus callosum changes in Alzheimer's disease: comparison between tract-based spatial statistics and atlas-based tractography
    Maria Giulia Preti
    Magnetic Resonance Laboratory, Don Gnocchi Foundation, Milan, Italy
    PLoS ONE 7:e35856. 2012
    ..e., amnestic Mild Cognitive Impairment; aMCI), especially when investigating the corpus callosum (CC)...
  29. pmc Properties and fate of oligodendrocyte progenitor cells in the corpus callosum, motor cortex, and piriform cortex of the mouse
    Laura E Clarke
    Department of Neuroscience, Physiology, and Pharmacology, University College London, London, WC1E 6BT, United Kingdom
    J Neurosci 32:8173-85. 2012
    Oligodendrocyte progenitor cells (OPCs) in the postnatal mouse corpus callosum (CC) and motor cortex (Ctx) reportedly generate only oligodendrocytes (OLs), whereas those in the piriform cortex may also generate neurons...
  30. ncbi Interhemispheric hypoconnectivity in schizophrenia: fiber integrity and volume differences of the corpus callosum in patients and unaffected relatives
    Christian Knöchel
    Laboratory of Neurophysiology and Neuroimaging, Dept of Psychiatry, Goethe Univ, Frankfurt Main, Germany
    Neuroimage 59:926-34. 2012
    ..to structural MRI and diffusion tensor imaging (DTI) data and examined volume and fiber integrity of the corpus callosum (CC), the main interhemispheric fiber tract, in 16 chronic schizophrenia (SZ) patients, matched first degree ..
  31. ncbi The core FOXG1 syndrome phenotype consists of postnatal microcephaly, severe mental retardation, absent language, dyskinesia, and corpus callosum hypogenesis
    Fanny Kortüm
    Institut fur Humangenetik, Universitatsklinikum Hamburg Eppendorf, Campus Forschung, Martinistrase 52, 20246 Hamburg, Germany
    J Med Genet 48:396-406. 2011
    ..This study aimed to further characterise and delineate the phenotype of FOXG1 mutation positive patients...
  32. ncbi Corpus callosum morphology and its relationship to cognitive function in neurofibromatosis type 1
    Natalie Pride
    Department of Psychology, Macquarie University, Sydney, Australia
    J Child Neurol 25:834-41. 2010
    ..type 1 (NF1) is associated with cognitive dysfunction and structural brain abnormalities such as an enlarged corpus callosum. This study aimed to determine the relationship between corpus callosum morphology and cognitive function in ..
  33. ncbi Impairment in explicit visuomotor sequence learning is related to loss of microstructural integrity of the corpus callosum in multiple sclerosis patients with minimal disability
    L Bonzano
    Department of Neurosciences, Ophthalmology and Genetics, and Istituto Nazionale Neuroscienze, University of Genoa, Genoa, Italy
    Neuroimage 57:495-501. 2011
    ..Also, as both hemispheres are involved, we could hypothesize that the corpus callosum (CC) has a role in this process...
  34. ncbi Probabilistic topography of human corpus callosum using cytoarchitectural parcellation and high angular resolution diffusion imaging tractography
    Yi Ping Chao
    Interdisciplinary MRI MRS Laboratory, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan
    Hum Brain Mapp 30:3172-87. 2009
    The function of the corpus callosum (CC) is to distribute perceptual, motor, cognitive, learned, and voluntary information between the two hemispheres of the brain...
  35. ncbi In vivo structural neuroanatomy of corpus callosum in Alzheimer's disease and mild cognitive impairment using different MRI techniques: a review
    Margherita Di Paola
    Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 20:67-95. 2010
    The corpus callosum (CC), which connects the two cerebral hemispheres, is the largest white matter fiber bundle in the human brain...
  36. pmc Longitudinal changes in the corpus callosum following pediatric traumatic brain injury
    Trevor C Wu
    Department of Psychology, Brigham Young University, Provo, Utah, USA
    Dev Neurosci 32:361-73. 2010
    Atrophy of the corpus callosum (CC) is a documented consequence of moderate-to-severe traumatic brain injury (TBI), which has been expressed as volume loss using quantitative magnetic resonance imaging (MRI)...
  37. pmc A comparative MRI study of the relationship between neuroanatomical asymmetry and interhemispheric connectivity in primates: implication for the evolution of functional asymmetries
    W D Hopkins
    Department of Psychology, Berry College, USA
    Behav Neurosci 114:739-48. 2000
    ..connectivity by examining whether neuroanatomical asymmetries were associated with variation in the ratio of corpus callosum size to brain volume (CC:VOL) and to neocortical surface area (CC:NEO) in human and nonhuman primates...
  38. pmc Mapping of deletion and translocation breakpoints in 1q44 implicates the serine/threonine kinase AKT3 in postnatal microcephaly and agenesis of the corpus callosum
    Elena Boland
    Academic Unit of Medical Genetics and Regional Genetic Service, St Mary s Hospital, and Centre for Molecular Medicine, The University of Manchester, M13 0JH, UK
    Am J Hum Genet 81:292-303. 2007
    ..in a variety of developmental abnormalities of the brain, including microcephaly (MIC) and agenesis of the corpus callosum (ACC)...
  39. ncbi Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum
    Ainhoa Etxeberria
    Center for Neuroscience Research, Children s National Medical Center, Washington, DC, USA
    Nat Neurosci 13:287-9. 2010
    ..progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after ..
  40. pmc White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging
    M Bozzali
    Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy
    J Neurol Neurosurg Psychiatry 72:742-6. 2002
    ..To investigate the extent and the nature of white matter tissue damage of patients with Alzheimer's disease using diffusion tensor magnetic resonance imaging (DT-MRI)...
  41. ncbi Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo
    Paola Arlotta
    MGH HMS Center for Nervous System Repair, Departments of Neurosurgery and Neurology, Program in Neuroscience and Harvard Stem Cell Institute, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Neuron 45:207-21. 2005
    ....
  42. ncbi Activity-dependent development of callosal projections in the somatosensory cortex
    Chun Lei Wang
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 27:11334-42. 2007
    The corpus callosum is the largest commissural system in the mammalian brain, but the mechanisms underlying its development are not well understood...
  43. ncbi A critical re-examination of sexual dimorphism in the corpus callosum microstructure
    Rene Westerhausen
    Department of Biological and Medical Psychology, University of Bergen, Bergen, Norway
    Neuroimage 56:874-80. 2011
    ..diffusion-tensor imaging (DTI) studies suggest sexual dimorphism in the micro-structural architecture of the corpus callosum. However, the corpus callosum is also found to be larger in males than in females, a fact that might ..
  44. ncbi Social and behavioral problems of children with agenesis of the corpus callosum
    Denise H Badaruddin
    The Travis Research Institute, Center for Biopsychosocial Research, Fuller Graduate School of Psychology, 180 N Oakland Ave, Pasadena, CA 91101, USA
    Child Psychiatry Hum Dev 38:287-302. 2007
    ..was used to determine the prevalence of social and behavioral problems in children with agenesis of the corpus callosum (ACC)...
  45. ncbi Mapping corpus callosum deficits in autism: an index of aberrant cortical connectivity
    Christine N Vidal
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 7332, USA
    Biol Psychiatry 60:218-25. 2006
    Volumetric studies have reported reductions in the size of the corpus callosum (CC) in autism, but the callosal regions contributing to this deficit have differed among studies...
  46. pmc Sex-dependent influences of obesity on cerebral white matter investigated by diffusion-tensor imaging
    Karsten Mueller
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    PLoS ONE 6:e18544. 2011
    ..In female and male subjects, the putative axon marker λ(∥) was consistently reduced throughout the corpus callosum, particularly in the splenium (r = -0.62, p<0.005)...
  47. ncbi Cortical projection topography of the human splenium: hemispheric asymmetry and individual differences
    Mary Colvin Putnam
    Harvard Medical School, USA
    J Cogn Neurosci 22:1662-9. 2010
    The corpus callosum is the largest white matter pathway in the human brain. The most posterior portion, known as the splenium, is critical for interhemispheric communication between visual areas...
  48. pmc Epigenetic memory loss in aging oligodendrocytes in the corpus callosum
    Siming Shen
    Department Neuroscience and Cell Biology, Robert Wood Johnson Medical School, UMDNJ, Piscataway, NJ 08854, USA
    Neurobiol Aging 29:452-63. 2008
    ....
  49. ncbi DTI tractography based parcellation of white matter: application to the mid-sagittal morphology of corpus callosum
    Hao Huang
    Johns Hopkins University School of Medicine, Department of Radiology, Division of MRI Research, Baltimore, MD 21205, USA
    Neuroimage 26:195-205. 2005
    Morphology of the corpus callosum (CC) at the mid-sagittal level has been a target of extensive studies...
  50. pmc Functional anatomy of interhemispheric cortical connections in the human brain
    Mojtaba Zarei
    Oxford Centre for Functional MRI of the Brain, Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
    J Anat 209:311-20. 2006
    ..interaction between the human cerebral hemispheres is served by abundant white-matter fibres in the human corpus callosum (CC)...
  51. ncbi Human motor corpus callosum: topography, somatotopy, and link between microstructure and function
    Mathias Wahl
    Department of Neurology, Johann Wolfgang Goethe University of Frankfurt, D 60528 Frankfurt am Main, Germany
    J Neurosci 27:12132-8. 2007
    The corpus callosum (CC) is the principal white matter fiber bundle connecting neocortical areas of the two hemispheres...
  52. pmc Evolution amplified processing with temporally dispersed slow neuronal connectivity in primates
    Roberto Caminiti
    Department of Physiology and Pharmacology, University of Rome La Sapienza, 00185 Rome Italy
    Proc Natl Acad Sci U S A 106:19551-6. 2009
    The corpus callosum (CC) provides the main route of communication between the 2 hemispheres of the brain. In monkeys, chimpanzees, and humans, callosal axons of distinct size interconnect functionally different cortical areas...
  53. pmc A meta-analysis of the corpus callosum in autism
    Thomas W Frazier
    Center for Autism and Center for Pediatric Behavioral Health, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Biol Psychiatry 66:935-41. 2009
    Previous magnetic resonance imaging (MRI) studies have reported reductions in corpus callosum (CC) total area and CC regions in individuals with autism...
  54. pmc CXCR4 promotes differentiation of oligodendrocyte progenitors and remyelination
    Jigisha R Patel
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:11062-7. 2010
    ..we evaluated the expression of CXCL12 and its receptor, CXCR4, within the demyelinating and remyelinating corpus callosum (CC)...
  55. ncbi Reduced anterior corpus callosum white matter integrity is related to increased impulsivity and reduced discriminability in cocaine-dependent subjects: diffusion tensor imaging
    Frederick Gerard Moeller
    Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Neuropsychopharmacology 30:610-7. 2005
    ..Since prefrontal cortical axonal tracts cross between hemispheres in the corpus callosum, it is possible that white matter integrity in the corpus callosum could also be diminished in cocaine-..
  56. ncbi Mechanisms regulating the development of the corpus callosum and its agenesis in mouse and human
    L J Richards
    The University of Maryland School of Medicine, Department of Anatomy and Neurobiology and Programs in Neuroscience and Membrane Biology, Baltimore, MD 21201, USA
    Clin Genet 66:276-89. 2004
    The development of the corpus callosum depends on a large number of different cellular and molecular mechanisms...
  57. pmc Predicting inter-hemispheric transfer time from the diffusion properties of the corpus callosum in healthy individuals and schizophrenia patients: a combined ERP and DTI study
    Thomas J Whitford
    Psychiatry Neuroimaging Laboratory, Brigham and Women s Hospital, HarvardMedical School, Boston, MA 02215, USA
    Neuroimage 54:2318-29. 2011
    ..The present study investigated whether or not these IHTT abnormalities could be underpinned by structural damage to the visual fibers of the corpus callosum.
  58. pmc Callosal atrophy in mild cognitive impairment and Alzheimer's disease: different effects in different stages
    Margherita Di Paola
    IRCCS Santa Lucia Foundation, Via Ardeatina 306, Rome, Italy
    Neuroimage 49:141-9. 2010
    ..Nevertheless, a number of investigations have documented white matter (WM) pathology associated with AD. The corpus callosum (CC) is the largest WM fiber bundle in the human brain...
  59. ncbi The corpus callosum in dichotic listening studies of hemispheric asymmetry: a review of clinical and experimental evidence
    Rene Westerhausen
    Department of Biological and Medical Psychology, Cognitive Neuroscience Group, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Neurosci Biobehav Rev 32:1044-54. 2008
    ..Although this interpretation is widely accepted, the cerebral hemispheres also interact through the corpus callosum. Moreover, the two most influential theoretical models of dichotic listening, the structural and the ..
  60. ncbi White matter damage of patients with Alzheimer's disease correlated with the decreased cognitive function
    Jin Hai Duan
    Department of Anatomy and Neurobiology, Preclinical Medicine School, Sun Yat Sen University, Guangzhou 510080, China
    Surg Radiol Anat 28:150-6. 2006
    ..to measure the fractional anisotropy (FA) and mean diffusivity (MD) in the genu and splenium of the corpus callosum, anterior and posterior limbs of the internal capsule, and the white matter of frontal, temporal, parietal, ..
  61. ncbi PDGF and FGF2 pathways regulate distinct oligodendrocyte lineage responses in experimental demyelination with spontaneous remyelination
    Joshua C Murtie
    Program in Molecular and Cell Biology, Uniformed Services University of the Health Sciences, Bethesda, MD 20814 4799, USA
    Neurobiol Dis 19:171-82. 2005
    ..These findings demonstrate distinct roles for PDGF and FGF2 in vivo in the context of a demyelinating disease with spontaneous remyelination...
  62. ncbi Heavy smokers show abnormal microstructural integrity in the anterior corpus callosum: a diffusion tensor imaging study with tract-based spatial statistics
    Fuchun Lin
    Wuhan Center for Magnetic Resonance, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan 430071, PR China
    Drug Alcohol Depend 129:82-7. 2013
    ..However, less is known about white matter microstructure in heavy cigarette smokers. In this study, we used diffusion tensor imaging (DTI) to investigate the integrity of the white matter microstructure in heavy smokers...
  63. pmc The role of corpus callosum development in functional connectivity and cognitive processing
    Leighton B N Hinkley
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e39804. 2012
    The corpus callosum is hypothesized to play a fundamental role in integrating information and mediating complex behaviors...
  64. ncbi Confirming white matter fMRI activation in the corpus callosum: co-localization with DTI tractography
    Erin L Mazerolle
    Institute for Biodiagnostics Atlantic, National Research Council, Halifax, Nova Scotia, Canada
    Neuroimage 50:616-21. 2010
    ..An established interhemispheric transfer task was employed to elicit activation in the corpus callosum. Diffusion tensor imaging (DTI) tractography was used to determine the existence of tracts that connected ..
  65. ncbi The neuropsychiatry of Niemann-Pick type C disease in adulthood
    Mark Walterfang
    Neuropsychiatry Unit, Level 2, John Cade Building, Royal Melbourne Hospital, Melbourne 3050, Australia
    J Neuropsychiatry Clin Neurosci 18:158-70. 2006
    ....
  66. ncbi Functional consequences of a section of the anterior part of the body of the corpus callosum: evidence from an interhemispheric transcallosal approach
    Johann Peltier
    Laboratory of Anatomy and Organogenesis, University of Picardy Jules Verne, Amiens, France
    J Neurol 259:1860-7. 2012
    ..The transcallosal approach transects a large number of callosal fibers. This damage accounts for the deficits of memory, the dysexecutive cognitive and behavioral syndrome, and disturbances in interhemispheric transfer of learning...
  67. ncbi The macrostructural and microstructural abnormalities of corpus callosum in children with attention deficit/hyperactivity disorder: a combined morphometric and diffusion tensor MRI study
    Qingjiu Cao
    Institute of Mental Health, Peking University, Beijing 100191, China
    Brain Res 1310:172-80. 2010
    The corpus callosum (CC) is one of focused target areas which may play an important role in the pathophysiology of attention deficit hyperactivity disorder (ADHD)...
  68. ncbi Adults with attention-deficit/hyperactivity disorder - a diffusion-tensor imaging study of the corpus callosum
    Margaretha Dramsdahl
    Division of Psychiatry, Haukeland University Hospital, Bergen, Norway
    Psychiatry Res 201:168-73. 2012
    The objective of the present study was to investigate the microstructure and the macrostructure of the corpus callosum (CC) in adults with Attention-Deficit/Hyperactivity Disorder (ADHD) by means of magnetic resonance imaging (MRI)...
  69. ncbi The role of the corpus callosum in interhemispheric transfer of information: excitation or inhibition?
    Juliana S Bloom
    Clinical and Developmental NeuroPsychology, University of Georgia, G 10 Aderhold Hall, Athens, Georgia 30602, USA
    Neuropsychol Rev 15:59-71. 2005
    The corpus callosum is the major neural pathway that connects homologous cortical areas of the two cerebral hemispheres...
  70. ncbi Neonatal brain structure on MRI and diffusion tensor imaging, sex, and neurodevelopment in very-low-birthweight preterm children
    Jessica Rose
    Department of Orthopaedic Surgery, Stanford University School of Medicine, Stanford, CA, USA
    Dev Med Child Neurol 51:526-35. 2009
    ..Brain abnormalities on MRI and DTI were not different between males and females except in the splenium of the corpus callosum, where males had lower DTI fractional anisotropy (p=0.025) and a higher apparent diffusion coefficient (p=0...
  71. ncbi White matter alteration of the cingulum in Parkinson disease with and without dementia: evaluation by diffusion tensor tract-specific analysis
    K Kamagata
    Department of Radiology, Juntendo University School of Medicine, 2 1 1, Hongo Bunkyo ku Tokyo 113 8421 Japan
    AJNR Am J Neuroradiol 33:890-5. 2012
    ..We used diffusion tensor tractography to investigate the FA of the cingulate fiber tracts in patients with PD with and without dementia...
  72. pmc Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum
    Shingo Miyata
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 6:e19859. 2011
    ..Our data strongly suggest that these abnornalities of oligodendrocytes are possibly related to depression-like symptoms...
  73. ncbi Bimanual motor coordination in agenesis of the corpus callosum
    Kendra L Oakes Mueller
    Travis Research Institute, Fuller Graduate School of Psychology, Pasadena, California 91101, USA
    Behav Neurosci 123:1000-11. 2009
    The nature and extent of deficiencies in bimanual motor coordination in individuals with agenesis of the corpus callosum (ACC) was studied using the computerized Bimanual Coordination Test (cBCT)...
  74. pmc Influence of corpus callosum damage on cognition and physical disability in multiple sclerosis: a multimodal study
    Sara Llufriu
    Center for Neuroimmunology, Service of Neurology, Hospital Clinic and Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    PLoS ONE 7:e37167. 2012
    b>Corpus callosum (CC) is a common target for multiple sclerosis (MS) pathology. We investigated the influence of CC damage on physical disability and cognitive dysfunction using a multimodal approach.
  75. ncbi Postnatal cellular contributions of the hippocampus subventricular zone to the dentate gyrus, corpus callosum, fimbria, and cerebral cortex
    Ivan Navarro-Quiroga
    Biology Department, Wesleyan University, Middletown, Connecticut 06459, USA
    J Comp Neurol 497:833-45. 2006
    ..Another subset included EGFP(+)/RIP(+) oligodendrocytes that migrated into the fimbria, corpus callosum, and cerebral cortex...
  76. ncbi Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
    Major frontal lobe tracts and corpus callosum (CC) were investigated in 32 children with autism spectrum disorder (ASD, mean age: 5 years), 12 nonautistic developmentally impaired children (DI, mean age: 4...
  77. pmc Myelination of the corpus callosum in male and female rats following complex environment housing during adulthood
    Julie A Markham
    Beckman Institute, University of Illinois at Urbana Champaign, Urbana, IL, USA
    Brain Res 1288:9-17. 2009
    ..We conclude that the sensitivity of myelination to experience is reduced in adulthood relative to development in both sexes...
  78. ncbi Evaluation of white matter damage in patients with Alzheimer's disease and in patients with mild cognitive impairment by using diffusion tensor imaging
    M Ukmar
    Unità Clinica Operativa di Radiologia, Universita degli Studi di Trieste, Ospedale di Cattinara, Strada di Fiume 447, 34149, Trieste, Italy
    Radiol Med 113:915-22. 2008
    ..The objective of this study was to evaluate white matter tissue damage in patients with Alzheimer's disease (AD) and in patients with mild cognitive impairment (MCI) using diffusion tensor imaging (DTI)...
  79. pmc Morphological and electrical properties of oligodendrocytes in the white matter of the corpus callosum and cerebellum
    Yamina Bakiri
    Department of Physiology, University College London, London, UK
    J Physiol 589:559-73. 2011
    ....
  80. pmc Levels of BDNF impact oligodendrocyte lineage cells following a cuprizone lesion
    Melissa W Vondran
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 31:14182-90. 2011
    ..the roles BDNF may play in the repair of a demyelinating lesion, the cuprizone model was used and the corpus callosum was examined...
  81. ncbi Corpus callosum: musician and gender effects
    Dennis J Lee
    Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Ave, Boston, MA 02215, USA
    Neuroreport 14:205-9. 2003
    Previously we found that musicians have significantly larger anterior corpus callosum (CC)...
  82. ncbi Quantitative trait loci implicated in corpus callosum midsagittal area in mice
    I L Roy
    UPR CNRS 9074, Genetique, Neurogénétique, Comportement, Institut de Transgénose, CNRS, 3 B Rue de la Ferollerie, 45071, Orléans cedex 02, France
    Brain Res 811:173-6. 1998
    The midsagittal area of the corpus callosum expressed as the percentage of the hemispheric surface is smaller in the NZB/BlNJ than in the C57BL/6By inbred strain of mice. We performed a QTL mapping analysis using 284 F2s...
  83. ncbi Development of the corpus callosum in childhood, adolescence and early adulthood
    Matcheri S Keshavan
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213 2593, USA
    Life Sci 70:1909-22. 2002
    The corpus callosum (CC) is the major commissure connecting the cerebral hemispheres and there is evidence of its continuing development into young adulthood [Ann. Neurol. 34 (1993) 71]...
  84. ncbi Interhemispheric motor inhibition: its role in controlling electromyographic mirror activity
    Annemarie Hübers
    Motor Cortex Group, Department of Neurology, Goethe University, D 60528 Frankfurt am Main, Germany
    Eur J Neurosci 28:364-71. 2008
    ..These results provide strong and consistent evidence that transcallosal inhibitory interhemispheric interaction provides a significant route by which unwanted MA during intended unimanual motor tasks can be controlled...
  85. pmc Specificity of neuronal responses in primary visual cortex is modulated by interhemispheric corticocortical input
    Kerstin E Schmidt
    Max Planck Research Group Cortical Function and Dynamics, Max Planck Institute for Brain Research, Deutschordenstraße 46, Frankfurt Main, Germany
    Cereb Cortex 20:2776-86. 2010
    ..In conclusion, our results support the view that interhemispheric interactions mainly perform integrative functions similar to those of connections intrinsic to one hemisphere...
  86. ncbi Diffusion tensor changes in patients with amnesic mild cognitive impairment and various dementias
    Ta Fu Chen
    Department of Neurology, National Taiwan University Hospital, College of Medicine, Taipei, Taiwan
    Psychiatry Res 173:15-21. 2009
    ..in the left anterior periventricular (PV) area, possibly in the right posterior PV area, and the genu of the corpus callosum. AD patients showed DTC in the corpus callosum, and in frontal and parieto-occipital subcortical and anterior ..
  87. pmc The corpus callosum in first episode schizophrenia: a diffusion tensor imaging study
    G Price
    Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK
    J Neurol Neurosurg Psychiatry 76:585-7. 2005
    Neuropathological and imaging studies suggest that corpus callosum abnormalities (CC) are present in schizophrenia, but it remains to be determined whether these abnormalities are present at illness onset...
  88. ncbi Asymmetry of parietal interhemispheric connections in humans
    Giacomo Koch
    Laboratory of Clinical and Behavioural Neurology, Santa Lucia Foundation IRCCS, 00179 Rome, Italy
    J Neurosci 31:8967-75. 2011
    ..imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ..
  89. pmc The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents
    Ryan L Muetzel
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 39:1918-25. 2008
    Cross-sectional and longitudinal volumetric studies suggest that the corpus callosum (CC) continues to mature structurally from infancy to adulthood...
  90. ncbi Social processing deficits in agenesis of the corpus callosum: narratives from the Thematic Appreciation Test
    Lynn K Paul
    Fuller Graduate School of Psychology, The Travis Research Institute, Center for Biopsychosocial Research, 180 North Oakland Avenue, Pasadena, CA 91101, USA
    Arch Clin Neuropsychol 19:215-25. 2004
    Clinical observations suggest that individuals with agenesis of the corpus callosum (ACC) and normal IQ may have deficits in social intelligence...
  91. ncbi Corpus callosum atrophy in patients with mild Alzheimer's disease
    Kristian Steen Frederiksen
    Department of Neurology, Memory Disorders Research Group, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark kristian steen frederiksen rh regionh dk
    Neurodegener Dis 8:476-82. 2011
    Several studies have found atrophy of the corpus callosum (CC) in patients with Alzheimer's disease (AD)...
  92. ncbi Reliable callosal measurement: population normative data confirm sex-related differences
    Tejal N Mitchell
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, Queen Square, London, UK
    AJNR Am J Neuroradiol 24:410-8. 2003
    ..We sought to define a reliable and easily repeatable method for CCA measurement and to examine the effects of sex, age, handedness, and cerebral volume...
  93. pmc The hippocampal fimbria of cuprizone-treated animals as a structure for studying neuroprotection in multiple sclerosis
    M Kipp
    Institute of Neuroanatomy, Faculty of Medicine, RWTH Aachen University, Wendlingweg 2, 52074, Aachen, Germany
    Inflamm Res 60:723-6. 2011
    ..The understanding of NAWM biology in an established disease model might help to clarify why some of them progress to active demyelinating lesions...
  94. ncbi Connectivity and the corpus callosum in autism spectrum conditions: insights from comparison of autism and callosal agenesis
    Rhonda Booth
    MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, London, UK
    Prog Brain Res 189:303-17. 2011
    ..we review this work and summarize findings from our recent research comparing autism and agenesis of the corpus callosum (AgCC)...
  95. ncbi Bimanual coordination and corpus callosum microstructure in young adults with traumatic brain injury: a diffusion tensor imaging study
    Karen Caeyenberghs
    Motor Control Laboratory, Research Center for Movement Control and Neuroplasticity, K U Leuven, Belgium
    J Neurotrauma 28:897-913. 2011
    ..the upper extremities rely on precise timing, which requires efficient interhemispheric communication via the corpus callosum (CC)...
  96. ncbi How does the corpus callosum mediate interhemispheric transfer? A review
    Lisette J van der Knaap
    Helmholtz Institute, Experimental Psychology, Utrecht University, Utrecht, The Netherlands
    Behav Brain Res 223:211-21. 2011
    The corpus callosum is the largest white matter structure in the human brain, connecting cortical regions of both hemispheres...
  97. pmc Retinal input influences the size and corticocortical connectivity of visual cortex during postnatal development in the ferret
    A S Bock
    Department of Psychology, University of Washington, Seattle, Washington 98195 1525, USA
    J Comp Neurol 520:914-32. 2012
    ..A system that shows dramatic dependence on retinal influences is the interhemispheric connection through the corpus callosum. Using ferrets, we analyzed the extent to which development of the visual callosal pattern depends on retinal ..
  98. ncbi Transcallosal inhibition dampens neural responses to high contrast stimuli in human visual cortex
    T Bocci
    Department of Neuroscience, Unit of Neurology, Pisa University Medical School, Via Roma 55, 56126 Pisa, Italy Department of Neuroscience, Neurology and Clinical Neurophysiology Section, Azienda Ospedaliera Universitaria Senese, Viale Bracci 1, 53100 Siena, Italy
    Neuroscience 187:43-51. 2011
    Visual cortical areas in the two hemispheres interact via the corpus callosum, but the precise role of the callosal pathway in visual processing remains controversial...
  99. ncbi Detecting abnormalities of corpus callosum connectivity in autism using magnetic resonance imaging and diffusion tensor tractography
    Shanshan Hong
    Department of Neurology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, 214400 China
    Psychiatry Res 194:333-9. 2011
    The corpus callosum (CC) has emerged as one of the primary targets of autism research...
  100. ncbi Anisotropy of callosal motor fibers in combination with transcranial magnetic stimulation in the course of motor development
    Inga Koerte
    Institute of Clinical Radiology, Ludwig Maximilians University, Munich, Germany
    Invest Radiol 44:279-84. 2009
    The corpus callosum (CC) represents a key structure for hand motor development and is accessible to investigation by diffusion tensor magnetic resonance imaging (DTI) and transcranial magnetic stimulation (TMS)...
  101. ncbi Acute and chronic changes in diffusivity measures after sports concussion
    Luke C Henry
    Département de Psychology, Universite de Montreal, Montreal, Quebec, Canada
    J Neurotrauma 28:2049-59. 2011
    ..main group effect of FA, which was increased in dorsal regions of both corticospinal tracts (CST) and in the corpus callosum in concussed athletes at both time points...

Research Grants64

  1. Endothelial-reactive antibodies: a diagnostic test for Susac's syndrome
    WILLIAM JAMES WALDMAN; Fiscal Year: 2011
    ..While magnetic resonance imaging (MRI) consistently shows a distinctive white matter disturbance in the corpus callosum, lesions commonly detected by MRI in other regions of the brain may lead to misdiagnosis as multiple ..
  2. The Role of Connexin32 in the Pathogensis of CMTX
    STEVEN SIMON SCHERER; Fiscal Year: 2013
    ..We also showed, expectedly, O: O coupling was prominent in the corpus callosum, that O: O coupling was also lost in mice lacking both Cx32 and Cx47, that the GJs directly join ..
  3. MOLECULAR BASIS OF CONGENITAL STRABISMUS
    Elizabeth C Engle; Fiscal Year: 2013
    ..highlighted a spectrum of abnormalities including hypoplasia of oculomotor nerves, and dysgenesis of the corpus callosum, anterior commissure, and corticospinal tracts...
  4. Neuromorphometry of Psychosis in Bipolar Disorder
    Daniel Mamah; Fiscal Year: 2013
    ..and generate volume and shape metrics for the hippocampus, thalamus and basal ganglia, and measures of corpus callosum integrity, 2) compare these measures between PBD, NPBD, SCZ and controls, and 3) correlate lifetime ..
  5. Long term consequences of white matter damage by perinatal hyperoxia.
    Vittorio Gallo; Fiscal Year: 2013
    ..However, when WM is analyzed by diffusion tensor imaging later in adulthood, significant abnormalities in corpus callosum are detected which indicate long term changes in myelination...
  6. A Follow-up of Children Enrolled in the Management of Myelomeningocele Study
    ELIZABETH ANN THOM; Fiscal Year: 2013
    ..if there are differences by group in the microstructural organization of white matter tracts, such as the corpus callosum and projection and association pathways...
  7. FETAL PROGRAMMING OF THE NEWBORN AND INFANT HUMAN BRAIN
    Pathik D Wadhwa; Fiscal Year: 2013
    ..from serial MRI scans, and white matter integrity (fractional anisotropy along major white matter tracts: corpus callosum genu and splenium tracts and uncinate fasciculus) will be derived from serial DTI scans...
  8. White Matter Lesions and Cortical Serotonergic Deafferentation in Older Adults
    Martijn L T M Muller; Fiscal Year: 2010
    ..that provide cortical innervations loop closely around the frontal horn of the ventricles and the anterior corpus callosum before fanning out to the neocortex...
  9. DEVELOPMENTAL STUDIES ON THE MOTOR SYSTEM
    Katherine Kalil; Fiscal Year: 2013
    ..Confocal microscopic imaging will be carried out in the corpus callosum, a cortical pathway that links the two cerebral hemispheres and is surrounded by gradients of Wnt5a...
  10. L1CAM Adhesion and Signaling Pathways in C. elegans
    Lihsia Chen; Fiscal Year: 2012
    ..Mutations in the human L1 gene result in the CRASH neurological disorder, the symptoms of which include corpus callosum hypoplasia, mental retardation, adducted thumbs, spastic paraplegia, and hydrocephalus...
  11. FMRI &DTI Study on Neural Predictor of Treatment Outcome of Cocaine Dependence
    Jiansong Xu; Fiscal Year: 2013
    ..His preliminary findings indicate that better integrity of white matter in the frontal lobes and anterior corpus callosum positively correlates with better treatment outcomes of cognitive behavioral therapy for cocaine dependence...
  12. White matter hypoxia in a novel model of MMP-mediated inflammation in SHR/SP
    GARY ALLEN ROSENBERG; Fiscal Year: 2013
    ..EPR) to measure ptO2 with lithium phthalocyanine (LiPc) microcrystals implanted stereotactically into the corpus callosum, and to correlate the impact of hypoxia on the structural changes in white matter with multimodal MRI;2) ..
  13. Modulation of oligodendrocyte development by voltage-operated calcium channels.
    PABLO MARTIN PAEZ; Fiscal Year: 2013
    ..Viral vectors expressing siRNAs for L-type VOCCs will be injected into the corpus callosum and the subventricular zone of newborn pups to analyze the in vivo migration and myelination capabilities of ..
  14. Complement protection and anaphylatoxins in neuroinflammation
    Brian Martin; Fiscal Year: 2009
    ..2) Loss of Crry expression creates an environment in the corpus callosum that facilitates complement activation...
  15. NEUROGENESIS AND MIGRATION IN DEVELOPING CEREBRAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    PROJECT SUMMARY (Sea instructions): Recent findings that white matter tracts, particularly the corpus callosum, show abnormal organization in autistic individuals have focused our interest on later steps of cortical maturation, and in ..
  16. Oligo-Vascular Signaling in Stroke
    Ken Arai; Fiscal Year: 2013
    ..In various mouse models of cerebral ischemia, we will assess OL/OPC integrity in corpus callosum and striatum (i.e. white matter damage)...
  17. Diffusion tensor MR spectroscopic imaging in human brain
    Stefan Posse; Fiscal Year: 2012
    ..spectrum disorder (ASD) generally demonstrate decreased water diffusion anisotropy in frontal cortex and corpus callosum, consistent with frontal disconnectivity theories of autism...
  18. Vulnerability of Aging White Matter to Ischemia
    Selva Baltan; Fiscal Year: 2013
    ..of either AMPA or kainate receptors in optic nerve but activation of Ca2+permeable AMPA receptors in corpus callosum mediate injury, suggesting a region specific mechanism of ischemic injury in young WM...
  19. Frontal Lobe Neuroimaging as a Biomarker of Chronic Traumatic Encephalopathy
    JULIE MARIE STAMM; Fiscal Year: 2012
    ..fasciculus, a white matter tract connecting the prefrontal cortex and temporal lobe, and the genu of the corpus callosum, a white matter pathway connecting the right and left prefrontal cortices...
  20. De novo copy number variation and gene discovery in human brain malformations
    William B Dobyns; Fiscal Year: 2012
    ..cytogenetically visible chromosome deletions and duplications, and that often occur together: agenesis of the corpus callosum (ACC), cerebellar vermis hypoplasia (CVH) including Dandy-Walker malformation (DWM), and polymicrogyria (PMG)...
  21. Molecular Controls over Callosal Projection Neuron Subtype Specification and Dive
    RYAN MARIE FAME; Fiscal Year: 2012
    ..population of excitatory projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum, and are the largest class of commissural neurons in placental mammals...
  22. Robust Localized Measures for Brain Networks
    Eric J Friedman; Fiscal Year: 2013
    ..we expect this project to be relevant to many brain disorders, we will initially focus on Agenesis of the Corpus Callosum (AgCC), an important connectivity disorder of the brain...
  23. Neuroimaging and Neuropathology of Mucopolysaccharidosis I
    Patricia I Dickson; Fiscal Year: 2013
    ..changes, and white matter abnormalities including decreased volume and fractional anisotropy of the corpus callosum (a white matter structure)...
  24. The Gateway Hypothesis: A new framework for unraveling diverse leukodystrophies
    John E Rash; Fiscal Year: 2013
    ..by intracellular recording electrophysiology;and 4) recording from oligodendrocytes in acute slices of mouse corpus callosum of normal and exercised wildtype and Cx29 knockout mice...
  25. COMPUTERIZED IMAGE ANALYSES OF MR SCANS IN SCHIZOPHRENIA
    Martha Shenton; Fiscal Year: 2009
    ..Additionally, we will evaluate the corpus callosum, the largest white matter fiber tract in the brain, mediating interhemispheric connections postulated to be ..
  26. MR Brain Diffusion Tensor Imaging in Schizophrenia
    Martha E Shenton; Fiscal Year: 2013
    ..that longer IHTT, and decreased asymmetry, will be correlated with DTI measures in posterior portions of the corpus callosum, the largest white matter tract in the brain, which, in turn, will be correlated with measures of speed of ..
  27. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    BRUCE MICHAEL FRANKEL; Fiscal Year: 2010
    ..system and SVZ with high-grade lesions like GBM "spreading" to midline structures and crossing the corpus callosum to the contralateral hemisphere...
  28. High-resolution diffusion tensor imaging in mouse models relevant to autism
    Harish Poptani; Fiscal Year: 2010
    ..of pathology, except evidence of transient increase in brain size along with some evidence of reduced corpus callosum and cerebellum size...
  29. Sulfatides Act as Endogenous Toxin Reducing Efficiency of Remyelination
    KATARZYNA CZAJKOWSKA PITUCH; Fiscal Year: 2013
    ..capacity o OPCs, by using the well-characterized oligodendrocyte precursor cells isolated from P7 rat corpus callosum. These studies will be performed by immunocytochemical analysis, flow cytometry and liquid chromatography-..
  30. Alzheimer's disease risk analyzed using population imaging genomics
    Paul M Thompson; Fiscal Year: 2012
    ..cortex (MFC) at rest and (2) white matter integrity in the associated cingulum tract and splenium of the corpus callosum. Our project advances the study of AD genetic risk by investigating how multiple risk genes interact to ..
  31. The Brain Morphology of Children with Cleft Lip and/or Palate
    MADELEINE BLAIR CHOLLET; Fiscal Year: 2010
    ..be used to test for structural differences in the inferior frontal gyrus, the superior temporal gyrus, and corpus callosum. Identified structural changes will be regressed against cognitive data (e.g...
  32. DIFFUSION OF SUBSTANCES THROUGH THE BRAIN
    Charles Nicholson; Fiscal Year: 2013
    ..extracellular diffusion of the probe ion tetramethylammonium have been made previously in three axes in both corpus callosum and in the molecular layer of the cerebellum...
  33. A Common Glial-Neuronal Progenitor in Postnatal Brain
    Vittorio Gallo; Fiscal Year: 2013
    ..and Dcx-GFP transgenic mice indicate that: i) after lysolecithin (LPC)-induced focal demyelination of the corpus callosum (CC), or after perinatal hypoxia (HX), GAD65-GFP+ and Dcx-GFP+ progenitor cells migrate from the SVZ into the ..
  34. New Approaches to Axonal Protection After TBI
    Thomas M Reeves; Fiscal Year: 2013
    ..on exciting new evidence that CFZ improves the properties of compound action potentials (CAPs) evoked in corpus callosum axons, following an experimental TBI in adult rats...
  35. Macrostructural and Microstructural Analysis of the Primate Corpus Callosum
    KIMBERLEY ANN PHILLIPS; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Understanding the connectivity of the corpus callosum (CC) is an important public health goal, as this structure is believed to be fundamentally important to the emergence of higher order cognitive ..
  36. Cortical Inhibition and Corpus Callosum Integrity in Cocaine Users
    Colleen A Hanlon; Fiscal Year: 2013
    ..The overarching goal of this proposal is to determine the extent to which changes in corpus callosum integrity (Specific Aim #1) and cortical inhibitory tone (Specific Aim #2) are related to atypical BOLD ..
  37. Subcortical Vascular Cognitive Impairment-A Longitudinal Perfusion Imaging Study
    Lisa C Silbert; Fiscal Year: 2013
    ..and perfusion-related microstructural white matter changes in normal appearing white matter (NAWM) and the corpus callosum, and 3) Determine MRI biomarkers of cognitive and motor decline...
  38. Extracellular Matrix Mediates Axonal Integrity Following Brain Injury
    Linda L Phillips; Fiscal Year: 2013
    ..Using the injured corpus callosum (CC) as a model, we have shown that postinjury change in matrix metalloproteinases (MMPs) is correlated with ..
  39. Buprenorphine effects on oligodendrocyte development and axonal growth
    Carmen Sato Bigbee; Fiscal Year: 2010
    ..Surprisingly, analysis of the corpus callosum indicated that, regardless of the dose, pups exposed to buprenorphine exhibited a significant increase in the ..
  40. Diffusional Kurtosis Assessment of the Cuprizone Mouse Model of Demylination
    Maria F Falangola; Fiscal Year: 2010
    ..damage and glial cells accumulation during the process of demyelination and remyelination that occur in the corpus callosum of the cuprizone mouse model PUBLIC HEALTH RELEVANCE: The questions addressed in this proposal are whether a ..
  41. The Role of Neurotrophins in Oligodendrocyte Function
    Cheryl F Dreyfus; Fiscal Year: 2012
    ..In addition, BDNF +/- mice exhibit decreases in MBP+ myelin profiles and NG2+ progenitors that develop in the corpus callosum. Preliminary studies suggest that they also exhibit blunted increases in NG2 and reduced MBP in response to a ..
  42. Longitudinal Study of Brain Recovery Following Abstinence From Cocaine
    Jay Nierenberg; Fiscal Year: 2012
    ..reported that fractional anisotropy (FA), a measure of WM integrity, is lower in the inferior frontal WM and corpus callosum. However, when we studied former cocaine-dependent patients who remained abstinent, we found that FA in ..
  43. Disconnection as a model for cognitive dysfunction in multiple sclerosis
    ERIC KLAWITER; Fiscal Year: 2013
    ..inter-hemispheric connectivity with measures of anatomical connectivity (diffusion tensor imaging in the corpus callosum) and corpus callosum atrophy, a common finding in MS...
  44. Trauma to developing brain: model refinement and therapeutic intervention
    LINDA J contact NOBLE; Fiscal Year: 2010
    ..brain region volumes and white matter integrity at adolescence, focusing on the cortex, hippocampus and corpus callosum, structures that show acute damage in both animal models and children...
  45. HYBRID Diffusion Imaging to Detect Acute White Matter Injury After Mild TBI
    Yu Chien Wu; Fiscal Year: 2012
    ..we will perform probability tractography to assess these parameters in tracts vulnerable to TBI including corpus callosum, pyramidal (corticospinal) tract, frontal subcortical WM, and the superior longitudinal fasiculus...
  46. Neuroendophenotypes and Risk for Posttraumatic Stress Disorder
    Negar Fani; Fiscal Year: 2012
    ..The arcuate fasciculus (AF) the cingulum bundle (CB), the corpus callosum (CC), have been highlighted in studies of maltreated children and mixed populations of adults with PTSD...
  47. L1 SIGNALING IN X-LINKED MENTAL RETARDATION
    Patricia Maness; Fiscal Year: 2000
    ..Several X-linked mental retardation syndromes including hydrocephalus, MASA syndrome, agenesis of the corpus callosum and corticopinal tract and spastic paraparesis are caused by mutations in the gene encoding L1, a neural cell ..
  48. Chemotherapy effect on brain structure, neurophysiology and psychomotor behavior
    Guang H Yue; Fiscal Year: 2013
    ..proposes longitudinal experiments in women diagnosed with breast cancer to examine the effects of CTh on the corpus callosum (CC) and corticospinal tract (CST) (Aim 1), on NPF that directly depends on the quality of CC/CST structure, ..
  49. Sensitive Periods, Brain Development and Depression
    Martin H Teicher; Fiscal Year: 2013
    ..In particular, we found that the hippocampus, corpus callosum and frontal cortex were maximally vulnerable at 3-5, 9=10 and 14-16 years of age, respectively...
  50. ALCOHOL INTERACTION WITH L1 CELL ADHESION MOLECULE
    MICHAEL CHARNESS; Fiscal Year: 1999
    ..Mental retardation, hydrocephalus, and agenesis of the corpus callosum are observed both in fetal alcohol syndrome (FAS) and in children with mutations in the gene for the cell ..
  51. Neurons in the subcallosal sling
    Linda Richards; Fiscal Year: 2005
    ..When the sling is severed the corpus callosum does not form; in congenitally acallosal mice or in marsupials (which lack a corpus callosum), there is no ..
  52. Effects of Blindness on Human Early Visual Pathways
    Ione Fine; Fiscal Year: 2013
    ..of early blindness on connections between the lateral geniculate nucleus and V1, and between V1 and the corpus callosum. Magnetic resonance spectroscopy will be used to examine the neurochemical effects of blindness on ..
  53. CELL ADHESION MOLECULES IN NERVOUS SYSTEM DEVELOPMENT
    Vance Lemmon; Fiscal Year: 2005
    ..In the early 1990's it was shown that mutations in the L1 gene in humans cause severe mental retardation (corpus callosum hypoplasia, adducted thumbs, spastic paraplegia, and hydrocephalus)...
  54. Gross morphological correlates to the minicolumnopathy of autism
    Manuel F Casanova; Fiscal Year: 2010
    ..alterations in the gyral window, gray/white matter ratio, parcellation of the white matter, and size of the corpus callosum. This grant proposes studying a unique series of cases (n = 58) derived from the Autism Tissue Program (ATP)...
  55. Reconnection of Neural Networks and Cognitive Recovery after Pediatric TBI
    Robert F Asarnow; Fiscal Year: 2013
    ..The corpus callosum (CC) and a frontal-temporal-parietal (FTP) network that subserves spatial working memory will be studied as ..
  56. In vivo assessment of Gas6 to protect oligodendrocytes and enhance remyelination
    Bridget Shafit Zagardo; Fiscal Year: 2009
    ..The hypothesis to be tested in this proposal is that exogenous gas6 administration directly to the corpus callosum can protect oligodendrocytes from cuprizone toxicity;and enhance remyelination during the recovery phase ..
  57. Posttraumatic Stress Disorder & Childhood Sexual Abuse: Psychobiology
    MICHAEL DE BELLIS; Fiscal Year: 2007
    ..and free cortisol levels and smaller intracranial and cerebral volumes, smaller midsaggital areas of the corpus callosum. and larger ventricles compared to non-abused controls...
  58. REMYELINATION AND AXON INTEGRITY IN CHRONIC DEMYELINATION
    Regina C Armstrong; Fiscal Year: 2010
    ..The FGF2-I- mice do not develop corpus callosum atrophy with chronic demyelination, which indicates a potential for remyelination to attenuate axon damage...
  59. EXPERIMENTAL ANALYSIS OF STRABISMUS
    Nancy Berman; Fiscal Year: 1980
    ..used to determine the relation between the degree and direction of aquint and the abnormal connection of the corpus callosum. The time course and critical period of development of abnormal callosal connections in strabismic animals ..
  60. Photo-Inducible Transcriptional Regulators
    John Koh; Fiscal Year: 2007
    ..L1, a biomedically important protein associated with the X-linked mental retardation syndrome CRASH (Corpus callosum agenesis, Retardation, Abducted thumbs, Spastic paraplegia, Hydrocephalus)...
  61. FETAL ALCOHOL EXPOSURE AND NMDA RECEPTOR INTERACTION
    ANDREA ELBERGER; Fiscal Year: 2001
    The corpus callosum (CC) can be absent or reduced in children with fetal alcohol syndrome (FAS) or alcohol related birth defect (ARBD)...
  62. EGFR activity in T cell-influenced glioma invasiveness & chemosensitivity
    Christopher Wheeler; Fiscal Year: 2007
    ..syngeneic wild-type, and DC-vaccinated syngeneic wild-type host brains, monitoring invasiveness into corpus callosum, ventricles, and cerebral cortex in vivo. (Aim #1a)...
  63. FETAL ALCOHOL EXPOSURE AND BRAIN DEVELOPMENT
    ANDREA ELBERGER; Fiscal Year: 2000
    DESCRIPTION: The corpus callosum (CC) can be absent (agenesis) in children with fetal alcohol syndrome (FAS). Preliminary data show that the CC is reduced, and surviving connections are abnormal, in rats with fetal alcohol exposure...
  64. A Macedonian Center for Ultrastructural Studies in Schizophrenia
    Gorazd Rosoklija; Fiscal Year: 2009
    ..of spines in frontal cortex and subiculum, and measures of axonal and myelin sheath diameters in optic nerve, corpus callosum, and cingulum bundle. A longstanding collaboration between the School of Medicine of the University }Ss...