temporal lobe

Summary

Summary: Lower lateral part of the cerebral hemisphere.

Top Publications

  1. ncbi The medial temporal lobe
    Larry R Squire
    Veterans Affairs Healthcare System, San Diego, California 92161, USA
    Annu Rev Neurosci 27:279-306. 2004
  2. ncbi Distributed and overlapping representations of faces and objects in ventral temporal cortex
    J V Haxby
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 293:2425-30. 2001
  3. pmc The medial temporal lobe and recognition memory
    H Eichenbaum
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 30:123-52. 2007
  4. ncbi Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language
    Gregory Hickok
    University of California, Irvine, CA 92612, USA
    Cognition 92:67-99. 2004
  5. ncbi Going beyond LTM in the MTL: a synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception
    Kim S Graham
    Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK
    Neuropsychologia 48:831-53. 2010
  6. ncbi Recognition memory: what are the roles of the perirhinal cortex and hippocampus?
    M W Brown
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol Medical School, Bristol BS8 1TD, UK
    Nat Rev Neurosci 2:51-61. 2001
  7. ncbi A randomized, controlled trial of surgery for temporal-lobe epilepsy
    S Wiebe
    Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Sciences Centre, Canada
    N Engl J Med 345:311-8. 2001
  8. ncbi Uniquely human social cognition
    Rebecca Saxe
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology 46 4019, 43 Vassar St, Cambridge MA, 02138, USA
    Curr Opin Neurobiol 16:235-9. 2006
  9. ncbi The Enigmatic temporal pole: a review of findings on social and emotional processing
    Ingrid R Olson
    Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut Street, Room B51, Philadelphia, PA 19104 6196, USA
    Brain 130:1718-31. 2007
  10. ncbi Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial
    Jerome Engel
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    JAMA 307:922-30. 2012

Detail Information

Publications301 found, 100 shown here

  1. ncbi The medial temporal lobe
    Larry R Squire
    Veterans Affairs Healthcare System, San Diego, California 92161, USA
    Annu Rev Neurosci 27:279-306. 2004
    The medial temporal lobe includes a system of anatomically related structures that are essential for declarative memory (conscious memory for facts and events)...
  2. ncbi Distributed and overlapping representations of faces and objects in ventral temporal cortex
    J V Haxby
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Science 293:2425-30. 2001
    ..These results indicate that the representations of faces and objects in ventral temporal cortex are widely distributed and overlapping...
  3. pmc The medial temporal lobe and recognition memory
    H Eichenbaum
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 30:123-52. 2007
    ....
  4. ncbi Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language
    Gregory Hickok
    University of California, Irvine, CA 92612, USA
    Cognition 92:67-99. 2004
    ....
  5. ncbi Going beyond LTM in the MTL: a synthesis of neuropsychological and neuroimaging findings on the role of the medial temporal lobe in memory and perception
    Kim S Graham
    Wales Institute of Cognitive Neuroscience, School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK
    Neuropsychologia 48:831-53. 2010
    Studies in rats and non-human primates suggest that medial temporal lobe (MTL) structures play a role in perceptual processing, with the hippocampus necessary for spatial discrimination, and the perirhinal cortex for object ..
  6. ncbi Recognition memory: what are the roles of the perirhinal cortex and hippocampus?
    M W Brown
    Medical Research Council, Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol Medical School, Bristol BS8 1TD, UK
    Nat Rev Neurosci 2:51-61. 2001
    The hallmark of medial temporal lobe amnesia is a loss of episodic memory such that patients fail to remember new events that are set in an autobiographical context (an episode). A further symptom is a loss of recognition memory...
  7. ncbi A randomized, controlled trial of surgery for temporal-lobe epilepsy
    S Wiebe
    Department of Clinical Neurological Sciences, University of Western Ontario, and London Health Sciences Centre, Canada
    N Engl J Med 345:311-8. 2001
    ..We conducted a randomized, controlled trial to assess the efficacy and safety of surgery for temporal-lobe epilepsy...
  8. ncbi Uniquely human social cognition
    Rebecca Saxe
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology 46 4019, 43 Vassar St, Cambridge MA, 02138, USA
    Curr Opin Neurobiol 16:235-9. 2006
    ....
  9. ncbi The Enigmatic temporal pole: a review of findings on social and emotional processing
    Ingrid R Olson
    Center for Cognitive Neuroscience, University of Pennsylvania, 3720 Walnut Street, Room B51, Philadelphia, PA 19104 6196, USA
    Brain 130:1718-31. 2007
    ..Because perceptual inputs remain segregated into dorsal (auditory), medial (olfactory) and ventral (visual) streams, the integration of emotion with perception is channel specific...
  10. ncbi Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial
    Jerome Engel
    Department of Neurology, David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    JAMA 307:922-30. 2012
    ..Despite reported success, surgery for pharmacoresistant seizures is often seen as a last resort. Patients are typically referred for surgery after 20 years of seizures, often too late to avoid significant disability and premature death...
  11. pmc Matching categorical object representations in inferior temporal cortex of man and monkey
    Nikolaus Kriegeskorte
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD 20892 1148, USA
    Neuron 60:1126-41. 2008
    ..Our findings suggest that primate IT across species may host a common code, which combines a categorical and a continuous representation of objects...
  12. ncbi People thinking about thinking people. The role of the temporo-parietal junction in "theory of mind"
    R Saxe
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, NE20 464, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Neuroimage 19:1835-42. 2003
    ..Thus, the role of the TPJ-M in understanding other people appears to be specific to reasoning about the content of mental states...
  13. pmc Functional compartmentalization and viewpoint generalization within the macaque face-processing system
    Winrich A Freiwald
    The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA
    Science 330:845-51. 2010
    ....
  14. ncbi Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston MA 02114, USA
    Brain 130:630-53. 2007
    ..subcomponents I, II and III; from the occipital-parietal region, the fronto-occipital fasciculus; from the temporal lobe, the middle longitudinal fasciculus and from rostral to caudal, the uncinate fasciculus, extreme capsule and ..
  15. pmc Functional neuroanatomy of remote episodic, semantic and spatial memory: a unified account based on multiple trace theory
    Morris Moscovitch
    Department of Psychology, University of Toronto and Rotman Research Institute Baycrest Centre, Ontario, Canada
    J Anat 207:35-66. 2005
    ....
  16. pmc Neural correlates of working memory in Temporal Lobe Epilepsy--an fMRI study
    J Stretton
    Epilepsy Society MRI Unit, Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK
    Neuroimage 60:1696-703. 2012
    ..that the hippocampus is not part of the neural substrate of working memory (WM), and that WM is preserved in Temporal Lobe Epilepsy (TLE). Recent imaging and neuropsychological data suggest this view may need revision...
  17. ncbi Fast readout of object identity from macaque inferior temporal cortex
    Chou P Hung
    McGovern Institute for Brain Research, Cambridge, MA 02139, USA
    Science 310:863-6. 2005
    ..This information generalized over a range of object positions and scales, even for novel objects. Coarse information about position and scale could also be read out from the same population...
  18. ncbi On the origin of interictal activity in human temporal lobe epilepsy in vitro
    Ivan Cohen
    EMI 0224, CHU Pitie Salpetriere, Universite Paris VI, 75013 Paris, France
    Science 298:1418-21. 2002
    ..Here, we describe a spontaneous, rhythmic activity initiated in the subiculum of slices from patients with temporal lobe epilepsy. Synchronous events were similar to interictal discharges of patient electroencephalograms...
  19. ncbi A cortical area selective for visual processing of the human body
    P E Downing
    School of Psychology, Centre for Cognitive Neuroscience, University of Wales, Bangor LL57 2AS, UK
    Science 293:2470-3. 2001
    ..This region was found in the lateral occipitotemporal cortex in all subjects tested and apparently reflects a specialized neural system for the visual perception of the human body...
  20. ncbi Perisylvian language networks of the human brain
    Marco Catani
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AZ, United Kingdom
    Ann Neurol 57:8-16. 2005
    ..The anatomical findings are also relevant to the evolution of language, provide a framework for Lichtheim's symptom-based neurological model of aphasia, and constrain, anatomically, contemporary connectionist accounts of language...
  21. pmc The interactive account of ventral occipitotemporal contributions to reading
    Cathy J Price
    Wellcome Trust Centre for Neuro imaging, University College London, London WC1N 3BG, UK
    Trends Cogn Sci 15:246-53. 2011
    ..We discuss how the Interactive Account explains left vOT responses during normal reading and developmental dyslexia; and how it accounts for the behavioural consequences of left vOT damage...
  22. ncbi Episodic memory, amnesia, and the hippocampal-anterior thalamic axis
    J P Aggleton
    School of Psychology, Cardiff University, Cardiff, CF1 3YG, Wales
    Behav Brain Sci 22:425-44; discussion 444-89. 1999
    ..The distinction between temporal lobe and diencephalic amnesia is of limited value in that a common feature of anterograde amnesia is damage to part ..
  23. ncbi Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe
    Alexander Hammers
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Hum Brain Mapp 19:224-47. 2003
    ..Its potential applications range from the automatic labeling of new scans to the detection of anatomical abnormalities in patients. Further data can be extracted from the atlas for the detailed analysis of individual structures...
  24. pmc The neural organization of semantic control: TMS evidence for a distributed network in left inferior frontal and posterior middle temporal gyrus
    Carin Whitney
    Department of Psychology and York Neuroimaging Centre, University of York, YO10 5DD York, UK
    Cereb Cortex 21:1066-75. 2011
    ..These results reveal that an extended network of prefrontal and posterior temporal regions underpins semantic control...
  25. ncbi The evolution of the arcuate fasciculus revealed with comparative DTI
    James K Rilling
    Department of Anthropology, Emory University, 207 Anthropology Building, 1557 Dickey Drive, Atlanta, Georgia 30322, USA
    Nat Neurosci 11:426-8. 2008
    ..we compared cortical connectivity in humans, chimpanzees and macaques (Macaca mulatta) and found a prominent temporal lobe projection of the human arcuate fasciculus that is much smaller or absent in nonhuman primates...
  26. pmc Separate coding of different gaze directions in the superior temporal sulcus and inferior parietal lobule
    Andrew J Calder
    Medical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, CB2 7EF Cambridge, United Kingdom
    Curr Biol 17:20-5. 2007
    ..Consistent with these findings, averted gaze in the adapted direction was misidentified as direct. Our study provides the first human evidence of dissociable neural systems for left and right gaze...
  27. pmc Concomitant fractional anisotropy and volumetric abnormalities in temporal lobe epilepsy: cross-sectional evidence for progressive neurologic injury
    Simon S Keller
    Department of Neurology, University of Munster, Munster, Germany Department of Clinical Neuroscience, Institute of Psychiatry, King s College London, London, United Kingdom
    PLoS ONE 7:e46791. 2012
    In patients with temporal lobe epilepsy and associated hippocampal sclerosis (TLEhs) there are brain abnormalities extending beyond the presumed epileptogenic zone as revealed separately in conventional magnetic resonance imaging (MRI) ..
  28. pmc Imaging memory in temporal lobe epilepsy: predicting the effects of temporal lobe resection
    Silvia B Bonelli
    NSE MRI Unit, National Society for Epilepsy, Chalfont St Peter, UK
    Brain 133:1186-99. 2010
    ..In patients with refractory temporal lobe epilepsy, evaluation of preoperative verbal and visual memory function is important as anterior temporal lobe ..
  29. ncbi Flexible memories: differential roles for medial temporal lobe and prefrontal cortex in cross-episode binding
    Dagmar Zeithamova
    Department of Psychology, Center for Learning and Memory, and Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 30:14676-84. 2010
    ..A critical question for memory research is how medial temporal lobe (MTL) and prefrontal cortex (PFC), regions implicated in rapid within-episode binding, further support cross-..
  30. ncbi DTI tractography of the human brain's language pathways
    Matthew F Glasser
    Department of Anthropology, Emory University, 1557 Dickey Drive, Atlanta, GA 30322, USA
    Cereb Cortex 18:2471-82. 2008
    ..Smaller right hemisphere MTG terminations overlapped with right lateralized prosodic activations. We combine our findings with a recent model of brain language processing to explain 6 aphasia syndromes...
  31. ncbi Functional MRI of language: new approaches to understanding the cortical organization of semantic processing
    Susan Bookheimer
    Brain Mapping Center, UCLA School of Medicine, 90095, USA
    Annu Rev Neurosci 25:151-88. 2002
    ..from other frontal lobe language functions, (b) the organization of categories of objects and concepts in the temporal lobe, and (c) the role of the right hemisphere in comprehending contextual and figurative meaning...
  32. ncbi Functional specialization in the human medial temporal lobe
    Morgan D Barense
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge CB2 2EF, United Kingdom
    J Neurosci 25:10239-46. 2005
    ..of memory in rats and nonhuman primates have demonstrated functional specialization within the medial temporal lobe (MTL), a set of heavily interconnected structures including the hippocampal formation and underlying ..
  33. pmc A cortical region consisting entirely of face-selective cells
    Doris Y Tsao
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Science 311:670-4. 2006
    ..Almost all (97%) of the visually responsive neurons in this region were strongly face selective, indicating that a dedicated cortical area exists to support face processing in the macaque...
  34. ncbi Structural brain abnormalities in major depressive disorder: a selective review of recent MRI studies
    Valentina Lorenzetti
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, Australia
    J Affect Disord 117:1-17. 2009
    ..While there is evidence to suggest that major depressive disorder (MDD) is associated with structural brain abnormalities, the precise nature of these abnormalities remains unclear...
  35. ncbi Imaging recollection and familiarity in the medial temporal lobe: a three-component model
    Rachel A Diana
    Center for Neuroscience, 1544 Newton Court, Davis, CA 95618, USA
    Trends Cogn Sci 11:379-86. 2007
    The medial temporal lobe (MTL) plays a crucial role in supporting memory for events, but the functional organization of regions in the MTL remains controversial, especially regarding the extent to which different subregions support ..
  36. pmc Working memory for conjunctions relies on the medial temporal lobe
    Ingrid R Olson
    The Center for Cognitive Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Neurosci 26:4596-601. 2006
    ..The task required patients with medial temporal lobe amnesia and controls to remember three objects, locations, or object-location conjunctions over 1 or 8 s ..
  37. ncbi Interaction between the amygdala and the medial temporal lobe memory system predicts better memory for emotional events
    Florin Dolcos
    Center for Cognitive Neuroscience, Duke University, Durham, North Carolina 27708, USA
    Neuron 42:855-63. 2004
    ..events are remembered better than neutral events possibly because the amygdala enhances the function of medial temporal lobe (MTL) memory system (modulation hypothesis)...
  38. pmc Distinct cortical anatomy linked to subregions of the medial temporal lobe revealed by intrinsic functional connectivity
    Itamar Kahn
    Department of Psychology and Center for Brain Science, Harvard University, Cambridge, Massachusetts, USA
    J Neurophysiol 100:129-39. 2008
    The hippocampus and adjacent cortical structures in the medial temporal lobe (MTL) contribute to memory through interactions with distributed brain areas...
  39. ncbi Regionally localized thinning of the cerebral cortex in schizophrenia
    Gina R Kuperberg
    Department of Psychiatry, Massachusetts General Hospital and Athinoula A Martinos Center for Biomedical Imaging, Charlestown, 02129, USA
    Arch Gen Psychiatry 60:878-88. 2003
    ....
  40. ncbi The representation of object concepts in the brain
    Alex Martin
    Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, Maryland 20892 1366, USA
    Annu Rev Psychol 58:25-45. 2007
    ..However, some property-based regions seem to show a categorical organization, thus providing evidence consistent with category-based, domain-specific formulations as well...
  41. ncbi The proactive brain: using analogies and associations to generate predictions
    Moshe Bar
    Martinos Center for Biomedical Imaging at MGH, Harvard Medical School, 149 Thirteenth Street, Charlestown, MA 02129, USA
    Trends Cogn Sci 11:280-9. 2007
    ..This cognitive neuroscience framework can help explain a variety of phenomena, ranging from recognition to first impressions, and from the brain's 'default mode' to a host of mental disorders...
  42. ncbi Both the middle temporal gyrus and the ventral anterior temporal area are crucial for multimodal semantic processing: distortion-corrected fMRI evidence for a double gradient of information convergence in the temporal lobes
    Maya Visser
    University of Manchester, Manchester, UK
    J Cogn Neurosci 24:1766-78. 2012
    ..Additional planned, ROI analyses show that this result follows from two principal axes of convergence in the temporal lobe: both lateral (toward MTG) and longitudinal (toward the anterior temporal lobe).
  43. ncbi Evolution of radiation-induced brain injury: MR imaging-based study
    Yi Xiang J Wang
    Department of Diagnostic Radiology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, People s Republic of China
    Radiology 254:210-8. 2010
    ..To evaluate the temporal lobes in patients previously treated for nasopharyngeal carcinoma to provide a better understanding of delayed radiation-induced injury in the brain unaffected by the underlying tumor...
  44. ncbi Perceptual deficits in amnesia: challenging the medial temporal lobe 'mnemonic' view
    Andy C H Lee
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, UK
    Neuropsychologia 43:1-11. 2005
    Recent animal studies suggest that the medial temporal lobe (MTL), which is thought to subserve memory exclusively, may support non-mnemonic perceptual processes, with the hippocampus and perirhinal cortex contributing to spatial and ..
  45. ncbi Neuroimaging evidence for dissociable forms of repetition priming
    R Henson
    Wellcome Department of Cognitive Neurology, Institute of Neurology, Institute of Cognitive Neuroscience and Department of Psychology, University College London, London WC1E 6BT, UK
    Science 287:1269-72. 2000
    ..Priming-related responses are therefore not unitary but depend on the presence or absence of preexisting stimulus representations...
  46. ncbi Practice parameter: temporal lobe and localized neocortical resections for epilepsy: report of the Quality Standards Subcommittee of the American Academy of Neurology, in association with the American Epilepsy Society and the American Association of Neuro
    J Engel
    Neurological Research Center, Department of Neurology 1250, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Neurology 60:538-47. 2003
    To examine evidence for effectiveness of anteromesial temporal lobe and localized neocortical resections for disabling complex partial seizures by systematic review and analysis of the literature since 1990.
  47. pmc Medial temporal lobe activity during source retrieval reflects information type, not memory strength
    Rachel A Diana
    Center for Neuroscience, University of California, Davis, CA 95618, USA
    J Cogn Neurosci 22:1808-18. 2010
    ....
  48. ncbi Visual working memory is impaired when the medial temporal lobe is damaged
    Ingrid R Olson
    Center for Cognitie Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cogn Neurosci 18:1087-97. 2006
    ..Impaired memory could not be attributed to memory load or perceptual problems. These findings suggest that the MTLs are critical for accurate visual WM...
  49. ncbi Perception and conception: temporal lobe activity during complex discriminations of familiar and novel faces and objects
    Morgan D Barense
    University of Toronto, Toronto, Ontario, M5S 3G3 Canada
    J Cogn Neurosci 23:3052-67. 2011
    Recent studies indicate that medial-temporal lobe (MTL) damage, either from focal lesions or neurodegenerative disease (e.g., semantic dementia), impairs perception as well as long-term declarative memory...
  50. ncbi The human medial temporal lobe processes online representations of complex objects
    Morgan D Barense
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 2EF, United Kingdom
    Neuropsychologia 45:2963-74. 2007
    There has been considerable debate as to whether structures in the medial temporal lobe (MTL) support both memory and perception, in particular whether the perirhinal cortex may be involved in the perceptual discrimination of complex ..
  51. pmc Neural systems for reading aloud: a multiparametric approach
    William W Graves
    Department of Neurology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Cereb Cortex 20:1799-815. 2010
    ..These data offer the first clear evidence, in a single study, for the separate neural correlates of orthography-phonology mapping and semantic access during reading aloud...
  52. ncbi Neural systems underlying the suppression of unwanted memories
    Michael C Anderson
    Department of Psychology, University of Oregon, Eugene, OR 97403, USA
    Science 303:232-5. 2004
    ..These results confirm the existence of an active forgetting process and establish a neurobiological model for guiding inquiry into motivated forgetting...
  53. ncbi Differential contribution of frontal and temporal cortices to auditory change detection: fMRI and ERP results
    Bertram Opitz
    Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Neuroimage 15:167-74. 2002
    ..The MR signal change in temporal lobe regions was larger for large than for medium deviants...
  54. ncbi Associative memory and the medial temporal lobes
    Andrew Mayes
    School of Psychological Sciences, University of Manchester, Manchester M13 9PL, UK
    Trends Cogn Sci 11:126-35. 2007
    ..Using this framework, we consider psychological, lesion and functional imaging evidence, highlighting how informational convergence in the brain underlies the associative nature of both memory and perception...
  55. ncbi Evaluation of the dual route theory of reading: a metanalysis of 35 neuroimaging studies
    G Jobard
    Groupe d Imagerie Neurofonctionnelle, CNRS, UMR 6095, CEA LRC36V, Universite de Caen, Université de Paris 5, 14074, Caen Cedex, France
    Neuroimage 20:693-712. 2003
    ..These results confirm the suitability of the dual route framework to account for activations observed in nonpathological subjects while they read...
  56. pmc Immune transcriptome alterations in the temporal cortex of subjects with autism
    Krassimira Garbett
    Department of Psychiatry, Vanderbilt University, Nashville, TN 37203 USA
    Neurobiol Dis 30:303-11. 2008
    ....
  57. ncbi Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
    Teresa R Franklin
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 51:134-42. 2002
    ..To date, a focal structural analysis of the brains of cocaine patients has not been undertaken...
  58. ncbi Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task
    Birgit A Vollm
    Neuroscience and Psychiatry Unit, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Neuroimage 29:90-8. 2006
    ..These results have implications for our understanding of disorders characterized by impairments of social cognition, such as autism and psychopathy...
  59. ncbi Semantic memory and the brain: structure and processes
    A Martin
    Laboratory of Brain and Cognition, National Institutes of Mental Health, Bethesda, MD 20892, USA
    Curr Opin Neurobiol 11:194-201. 2001
    ..In addition, different regions of the left lateral prefrontal cortex, and perhaps anterior temporal cortex, may have distinct roles in retrieving, maintaining and selecting semantic information...
  60. pmc Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut, USA
    Hum Brain Mapp 29:1265-75. 2008
    ..imaging (fMRI) data and a multivariate analysis method, independent component analysis, we combined the temporal lobe and the default modes to discriminate subjects with bipolar disorder, chronic schizophrenia, and healthy ..
  61. ncbi The neural basis of visual body perception
    Marius V Peelen
    Centre for Cognitive Neuroscience, School of Psychology, Brigantia Building, University of Wales, Bangor, Gwynedd, LL57 2AS, UK
    Nat Rev Neurosci 8:636-48. 2007
    ....
  62. pmc Comparing face patch systems in macaques and humans
    Doris Y Tsao
    Institute for Brain Research and Center for Advanced Imaging, University of Bremen, P O Box 330440, D 28334 Bremen, Germany
    Proc Natl Acad Sci U S A 105:19514-9. 2008
    ..Here, we examined the organization of face-selective regions across the temporal lobe in a large number of macaque and human subjects...
  63. ncbi Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: Inverse relationships during postadolescent brain maturation
    E R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 21:8819-29. 2001
    ....
  64. ncbi Contribution of human hippocampal region to novelty detection
    R Knight
    Department of Neurology, Center for Neuroscience, University of California, Davis, Veterans Medical Center 94553, USA
    Nature 383:256-9. 1996
    ..To examine further the role of the medial temporal lobe in novelty processing, I measured physiological responses to novel auditory and tactile stimuli in patients ..
  65. ncbi What the left and right anterior fusiform gyri tell us about semantic memory
    Marco Mion
    Department of Clinical Neurosciences, University of Cambridge, Addenbrooke s Hospital, Herchel Smith Building for Brain and Mind Sciences, Robinson Way, Cambridge CB2 0SZ, UK
    Brain 133:3256-68. 2010
    ..Although it is well-known that semantic dementia is associated with temporal lobe degeneration, controversy remains over whether the semantic deficit is due to diffuse temporal lobe damage, ..
  66. ncbi Micro-RNA abundance and stability in human brain: specific alterations in Alzheimer's disease temporal lobe neocortex
    Prerna Sethi
    Department of Health Information Management, Louisiana Technical University, Ruston, LA 71272, USA
    Neurosci Lett 459:100-4. 2009
    ..5h) for specific brain-enriched miRNAs. In short PMI Alzheimer's disease (AD)-affected temporal lobe neocortex, miRNA-9, miRNA-125b and miRNA-146a were found to be significantly up-regulated, an effect that was ..
  67. ncbi Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
    Gaelle Bettus
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine, 27 Boulevard Jean Moulin, Marseille, France
    Hum Brain Mapp 30:1580-91. 2009
    ..We used resting-state fMRI to study basal functional connectivity within temporal lobes in medial temporal lobe epilepsy (MTLE) during interictal period...
  68. ncbi A quantitative evaluation of cross-participant registration techniques for MRI studies of the medial temporal lobe
    Michael A Yassa
    Center for Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697, USA
    Neuroimage 44:319-27. 2009
    Accurate cross-participant alignment within the medial temporal lobe (MTL) region is critical for fMRI studies of memory...
  69. ncbi Voxel-based morphometry of temporal lobe epilepsy: an introduction and review of the literature
    Simon Sean Keller
    The Magnetic Resonance and Image Analysis Research Centre, University of Liverpool, Liverpool, United Kingdom
    Epilepsia 49:741-57. 2008
    ..and results of voxel-based morphometry (VBM) studies that have reported brain changes associated with temporal lobe epilepsy (TLE)...
  70. ncbi Integration of auditory and visual information about objects in superior temporal sulcus
    Michael S Beauchamp
    Laboratory of Brain and Cognition, National Institute of Mental Health, Bethesda, MD 20892 USA
    Neuron 41:809-23. 2004
    ..We suggest that pSTS/MTG is specialized for integrating different types of information both within modalities (e.g., visual form, visual motion) and across modalities (auditory and visual)...
  71. ncbi Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis
    Nicolas A Crossley
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:4129-37. 2009
    Superior temporal lobe dysfunction is a robust finding in functional neuroimaging studies of schizophrenia and is thought to be related to a disruption of fronto-temporal functional connectivity...
  72. ncbi Competition among multiple memory systems: converging evidence from animal and human brain studies
    Russell A Poldrack
    Department of Psychology and Brain Research Institute, Franz Hall, University of California at Los Angeles, PO Box 951563, Los Angeles, CA 90095 1563, USA
    Neuropsychologia 41:245-51. 2003
    ..separable cognitive or "declarative" and stimulus-response "habit" memory systems that rely upon the medial temporal lobe (e.g. hippocampus) and basal ganglia (e.g. caudate-putamen), respectively...
  73. ncbi Multiple anatomical systems embedded within the primate medial temporal lobe: implications for hippocampal function
    John P Aggleton
    School of Psychology, Cardiff University, 70 Park Place, Cardiff, CF10 3AT, Wales, UK
    Neurosci Biobehav Rev 36:1579-96. 2012
    A review of medial temporal lobe connections reveals three distinct groupings of hippocampal efferents...
  74. ncbi fMRI of the face-processing network in the ventral temporal lobe of awake and anesthetized macaques
    Shih pi Ku
    Max Planck Institute for Biological Cybernetics, Spemannstrasse 38, 72076, Tubingen, Germany
    Neuron 70:352-62. 2011
    ..may simply be the consequence of technical difficulties in obtaining high-quality MR images from the ventral temporal lobe. By using an optimized fMRI protocol we here report face-selective areas in ventral TE, the parahippocampal ..
  75. ncbi Convergent connectivity and graded specialization in the rostral human temporal lobe as revealed by diffusion-weighted imaging probabilistic tractography
    Richard J Binney
    University of Manchester, UK
    J Cogn Neurosci 24:1998-2014. 2012
    ..In recent years, multiple independent neuroscience investigations have implicated critical roles for the rostral temporal lobe in auditory and visual perception, language, and semantic memory...
  76. ncbi Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication
    R Swainson
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, UK
    Neuropsychologia 38:596-612. 2000
    ..mild, medicated (MPD) and severe, medicated (SPD) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic and two-pair ..
  77. ncbi Medial temporal lobe damage causes deficits in episodic memory and episodic future thinking not attributable to deficits in narrative construction
    Elizabeth Race
    VA Boston Healthcare System and Boston University School of Medicine, Boston, Massachusetts 02130, USA
    J Neurosci 31:10262-9. 2011
    The medial temporal lobe (MTL) makes critical contributions to episodic memory, but its contributions to episodic future thinking remain a matter of debate...
  78. pmc Radiation induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: a review of new avenues in its management
    Jing Chen
    Cancer Centre, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Radiat Oncol 6:128. 2011
    b>Temporal lobe necrosis (TLN) is the most debilitating late-stage complication after radiation therapy in patients with nasopharyngeal cancer (NPC)...
  79. ncbi Lateralization of ventral and dorsal auditory-language pathways in the human brain
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
    Neuroimage 24:656-66. 2005
    ..The connections are stronger in the dominant hemisphere, in agreement with previous studies of functional lateralization of auditory-language processing...
  80. ncbi Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders
    Monica Beneyto
    Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 32:1888-902. 2007
    ..Medial temporal lobe structural alterations have been implicated in schizophrenia and to a lesser extent in mood disorders...
  81. ncbi Morphing Marilyn into Maggie dissociates physical and identity face representations in the brain
    Pia Rotshtein
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, 12 Queen Square, London, UK
    Nat Neurosci 8:107-13. 2005
    ..These findings provide neurobiological support for a hierarchical model of face perception...
  82. ncbi Concept cells: the building blocks of declarative memory functions
    Rodrigo Quian Quiroga
    Department of Engineering, University of Leicester, UK
    Nat Rev Neurosci 13:587-97. 2012
    ..These studies have shown that neurons in the human medial temporal lobe respond in a remarkably selective and abstract manner to particular persons or objects, such as Jennifer ..
  83. pmc Impaired insulin sensitivity as indexed by the HOMA score is associated with deficits in verbal fluency and temporal lobe gray matter volume in the elderly
    Christian Benedict
    Department of Neuroscience, Uppsala University, Uppsala, Sweden
    Diabetes Care 35:488-94. 2012
    ....
  84. pmc Anterior temporal lobe connectivity correlates with functional outcome after aphasic stroke
    Jane E Warren
    Cognitive Neuroimaging Group, MRC Cyclotron Unit, Hammersmith Hospital, London W120NN, UK
    Brain 132:3428-42. 2009
    ....
  85. ncbi Occipito-temporal connections in the human brain
    Marco Catani
    Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK
    Brain 126:2093-107. 2003
    ..the occipito-temporal projection system: (i) a major associative connection between the occipital and anterior temporal lobe is provided by a fibre bundle whose origin, course and termination are consistent with classical descriptions ..
  86. pmc Structural anatomy of empathy in neurodegenerative disease
    Katherine P Rankin
    Memory and Aging Center, UCSF Department of Neurology, University of California San Francisco CA 94143 1207, USA
    Brain 129:2945-56. 2006
    ..The results suggest that the right anterior temporal and medial frontal regions are essential for real-life empathic behaviour...
  87. ncbi Superior temporal sulcus anatomical abnormalities in childhood autism: a voxel-based morphometry MRI study
    N Boddaert
    ERM 0205 INSERM CEA, Service Hospitalier Frederic Joliot, CEA, 91406, Orsay, France
    Neuroimage 23:364-9. 2004
    ..Therefore, the convergent anatomical and functional temporal abnormalities observed in autism may be important in the understanding of brain behavior relationships in this severe developmental disorder...
  88. pmc Investigating the interaction between spatial perception and working memory in the human medial temporal lobe
    Andy C H Lee
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX13UD, UK
    J Cogn Neurosci 22:2823-35. 2010
    There has been considerable debate surrounding the functions of the medial temporal lobe (MTL)...
  89. pmc Long-term effects of temporal lobe epilepsy on local neural networks: a graph theoretical analysis of corticography recordings
    Edwin van Dellen
    Department of Neurology, VU University Medical Center, Amsterdam, The Netherlands
    PLoS ONE 4:e8081. 2009
    Pharmaco-resistant temporal lobe epilepsy (TLE) is often treated with surgical intervention at some point...
  90. pmc Performance-related sustained and anticipatory activity in human medial temporal lobe during delayed match-to-sample
    Rosanna K Olsen
    Departments of Psychology, Stanford University, California 94305, USA
    J Neurosci 29:11880-90. 2009
    The medial temporal lobe (MTL)-hippocampus and surrounding perirhinal, parahippocampal, and entorhinal cortical areas-has long been known to be critical for long-term memory for events...
  91. pmc Social concepts are represented in the superior anterior temporal cortex
    Roland Zahn
    National Institutes of Health, National Institute of Neurological Disorders and Stroke, Cognitive Neuroscience Section, Bethesda, MD 20892 1440, USA
    Proc Natl Acad Sci U S A 104:6430-5. 2007
    ..By using functional MRI, we demonstrate that the anterior temporal lobe represents abstract social semantic knowledge in agreement with this patient evidence...
  92. ncbi Integrating what and when across the primate medial temporal lobe
    Yuji Naya
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Science 333:773-6. 2011
    ..memory or memory for the detailed events in our lives is critically dependent on structures of the medial temporal lobe (MTL). A fundamental component of episodic memory is memory for the temporal order of items within an episode...
  93. pmc Working memory, long-term memory, and medial temporal lobe function
    Annette Jeneson
    Department of Psychology, University of California, San Diego, 92093, USA
    Learn Mem 19:15-25. 2012
    Early studies of memory-impaired patients with medial temporal lobe (MTL) damage led to the view that the hippocampus and related MTL structures are involved in the formation of long-term memory and that immediate memory and working ..
  94. pmc Human medial temporal lobe damage can disrupt the perception of single objects
    Andy C H Lee
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom
    J Neurosci 30:6588-94. 2010
    The idea that the medial temporal lobe (MTL), traditionally viewed as an exclusive memory system, may also subserve higher-order perception has been debated fiercely...
  95. ncbi Neural basis of eye gaze processing deficits in autism
    Kevin A Pelphrey
    Duke UNC Brain Imaging and Analysis Center, Duke University, Durham, NC 27710, USA
    Brain 128:1038-48. 2005
    ..We conclude that lack of modulation of the STS region by gaze shifts that convey different intentions contributes to the eye gaze processing deficits associated with autism...
  96. ncbi Dissociation of automatic and strategic lexical-semantics: functional magnetic resonance imaging evidence for differing roles of multiple frontotemporal regions
    Brian T Gold
    Department of Anatomy and Neurobiology, Chandler Medical Center, University of Kentucky, Lexington, Kentucky 40536 0298, USA
    J Neurosci 26:6523-32. 2006
    ..These studies provide reproducible evidence for a neural dissociation between three well established components of the lexical-semantic processing system...
  97. ncbi Invariant visual representation by single neurons in the human brain
    R Quian Quiroga
    Computation and Neural Systems, California Institute of Technology, Pasadena, California 91125, USA
    Nature 435:1102-7. 2005
    ..We have previously shown that neurons in the human medial temporal lobe (MTL) fire selectively to images of faces, animals, objects or scenes...
  98. pmc The developmental origins of voice processing in the human brain
    Tobias Grossmann
    Centre for Brain and Cognitive Development, Birkbeck, University of London, Malet Street, London WC1E 7HX, UK
    Neuron 65:852-8. 2010
    ..The pattern of findings suggests that temporal regions specialize in processing voices very early in development and that, already in infancy, emotions differentially modulate voice processing in the right hemisphere...
  99. ncbi An implicit learning task activates medial temporal lobe in patients with Parkinson's disease
    Teena D Moody
    Department of Psychology, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Behav Neurosci 118:438-42. 2004
    Recent studies provide evidence for an interaction between a declarative memory system, dependent on the medial temporal lobe (MTL), and a habit memory system, dependent on the basal ganglia...
  100. pmc Recognition memory and the medial temporal lobe: a new perspective
    Larry R Squire
    Veterans Affairs Medical Center 116A, 3350 La Jolla Village Drive, San Diego, California 92161, USA
    Nat Rev Neurosci 8:872-83. 2007
    ..We also indicate ways in which the functions of the medial temporal lobe structures are different, and suggest that these structures work together in a cooperative and complementary ..
  101. ncbi An FMRI study of the role of the medial temporal lobe in implicit and explicit sequence learning
    Haline E Schendan
    Department of Psychology, Boston University, Boston, MA 02215, USA
    Neuron 37:1013-25. 2003
    ..substrates supporting implicit and explicit sequence learning, focusing especially upon the role of the medial temporal lobe. Participants performed a serial reaction time task (SRTT)...

Research Grants74

  1. The Medial Entorhinal Cortex and Temporal Lobe Epilepsy
    KAREN WILCOX; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is a devastating type of seizure disorder that is difficult to control with existing antiepileptic drugs...
  2. Cre, Dre Dual Lineage Model for Calcium Imaging and Optogenetic Manipulations
    Petr Tvrdik; Fiscal Year: 2013
    ..The proposed tools will allow us to study reactive astrocytes in mouse models of temporal lobe epilepsy and to investigate Hoxb8 mutant microglia, which have been implicated in obsessive compulsive-like ..
  3. Canonical Transient Receptor Potential (TRPC) subfamily function in Hippocampus.
    David E Clapham; Fiscal Year: 2013
    ..Damage to the hippocampus, from oxygen starvation, encephalitis, medial temporal lobe epilepsy, tumors, and Alzheimer's disease, may result in amnesia, the inability to form or retain new ..
  4. Virus-Host Interactions that Lead to Epilepsy
    Robert S Fujinami; Fiscal Year: 2013
    ..This is the first infection driven model of temporal lobe epilepsy...
  5. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..Kainate receptors have also been implicated in a number of neurological disorders including temporal lobe epilepsy, schizophrenia, autism, and neuropathic pain...
  6. Epigenetic modulation of epileptogenesis.
    PEYMAN GOLSHANI; Fiscal Year: 2010
    ..seizures remain a major source of disability despite advances in surgical and pharmacological treatment of temporal lobe epilepsy. Status epilepticus (SE) causes chronic seizures in animal models...
  7. Disruption of Extracellular Matrix-Glial Interactions in Schizophrenia
    Sabina Berretta; Fiscal Year: 2013
    ..Specific Aim 1 will test the hypothesis that, in schizophrenia, increased CSPG-positive glial cells in medial temporal lobe regions correspond to astrocytes, as suggested by previous results...
  8. MURINE TYPHUS: VECTOR BIOLOGY AND TRANSMISSION
    Abdu F Azad; Fiscal Year: 2013
    ..e., seizures, respiratory and kidney failure, and persistent frontal and temporal lobe dysfunction) or death...
  9. Astrocyte Function and Temporal Lobe Epilepsy
    JAY ROBERT VARGAS; Fiscal Year: 2010
    ..mechanisms underlying intracellular calcium signaling in reactive astrocytes in neurological disorders such as temporal lobe epilepsy (TLE)...
  10. Cognition in Rhesus Macaques in Relation to Age and Endocrine Status
    Henryk F Urbanski; Fiscal Year: 2013
    ..to aging and prefrontal cortex dysfunction;2) delayed non-matching-to-sample, a task probing primarily temporal lobe-based memory;3) a visuospatial cueing test of visual attention that is estrogen-sensitive, and 4) performance ..
  11. Calcium Signaling in a Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE), a devastating seizure disorder that is difficult to control with anticonvulsant drugs, often develops following an initia insult to the CNS...
  12. Brain Alterations And Cognitive Impairment in Older Adults with Heart Failure
    LISA C BRATZKE; Fiscal Year: 2012
    ..We will obtain neuropsychological measures of multiple domains, as well as MRI measurements of the temporal lobe and prefrontal cortex at baseline and 12-months.
  13. TRPV1 Channels in hippocampal neurons
    Julie A Kauer; Fiscal Year: 2010
    ..Furthermore, the hippocampus is nearly always involved in temporal lobe epilepsy...
  14. Development of Medial Temporal Lobe Function
    JOCELYNE H BACHEVALIER; Fiscal Year: 2013
    ..as schizophrenia, autism, Williams syndrome, and anxiety, and are associated with dysfunction of the medial temporal lobe structures and prefrontal cortex...
  15. Identifying neurons and circuits critical for epileptogenesis
    Istvan Mody; Fiscal Year: 2013
    ..b>Temporal lobe epilepsy (TLE) is the most common form of pharmaco- resistant epilepsies and is associated with significant ..
  16. Lateral Asymmetry in the Human Auditory System
    Yvonne S Sininger; Fiscal Year: 2010
    Lateralization of auditory function is a salient, biologically-important phenomenon. Auditory areas of left temporal lobe are specialized for temporal processing of rapidly changing, broadband sounds and the right auditory areas for ..
  17. Neurobiological basis of Depression as a Comorbidity in Epilepsy
    Andrey M Mazarati; Fiscal Year: 2010
    ..The objective of the project is to validate an experimental model of co-morbidity between depression and temporal lobe epilepsy (TLE), and to establish the mechanistic connection between the two states...
  18. Whole-brain fluorescence and brightfield imaging at single-cell level
    Pixuan Zhou; Fiscal Year: 2013
    ..treatments for important neurological disorders, such as Alzheimer's disease, Parkinson's disease, temporal lobe epilepsy, depression, and schizophrenia. Collectively, these disorders affect over 20 million Americans...
  19. Remote effects of focal hippocampal seizures on neocortical function
    Hal Blumenfeld; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Seizures have both local and remote effects on nervous system function. Temporal lobe epilepsy (TLE) is a common and debilitating neurological disorder, characterized by focal seizures arising from ..
  20. Somatic cell gene transfer/neurological &clinical applications
    En Ju Lin; Fiscal Year: 2013
    ..The astrogliosis which characterizes human temporal lobe epilepsy is associated with increased expression of adenosine kinase and has been proposed as a critical ..
  21. GABA(A) Receptor Subunit Regulation in Epileptogenesis
    Shelley J Russek; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is the most common form of epilepsy &is often medically intractable...
  22. Does in utero exposure to domoic acid cause temporal lobe epilepsy?
    Paul S Buckmaster; Fiscal Year: 2013
    ..veterinarians and biomedical scientists to test the hypothesis that in utero exposure to domoic acid causes temporal lobe epilepsy, albeit a milder form than that caused by adult exposure...
  23. Advancing Diagnosis and Functional Localization in Focal Epilepsy with Oxygen-Enh
    GIRIDHAR PADMANABHAN KALAMANGALAM; Fiscal Year: 2013
    ..produces a robust and diagnostically useful contrast MRI signal that achieves diagnosis and lateralization of temporal lobe epilepsy with good sensitivity and perfect specificity...
  24. Mechanisms of Synaptic Integration in Central Neurons
    William J Spain; Fiscal Year: 2012
    ..by injury to the neocortex is hard to manage medically and the surgical options are more restricted than for temporal lobe epilepsy. So we need to find better ways to treat this problem...
  25. Stem Cell Transplantation for Epilepsy
    JANICE RAE NAEGELE; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Our long-term goal is to advance cell-based treatments for severe temporal lobe epilepsy (TLE)...
  26. Immune evasion in a humanized mouse model of HHV-6 infection
    Amy W Hudson; Fiscal Year: 2013
    ..HHV6 DNA was found in 70% of brain tissue resections from mesial temporal lobe epilepsy (5)...
  27. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2012
    b>Temporal lobe epilepsy (TLE) with mesial temporal sclerosis (MTS) is often associated with a history of febrile seizures (FC). However, the proposed causal relationship between FCs and MTS remains controversial...
  28. GABA(A) RECEPTOR TRAFFICKING AND EPILEPTOGENESIS
    Marco I Gonzalez; Fiscal Year: 2013
    ..altered GABAAR subunit expression, synaptic localization and functional impairments in animal models of Temporal Lobe Epilepsy (TLE), but the molecular mechanisms triggering these changes are unknown...
  29. GABA Receptors and Hilar Neuron Survival in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..neurons in the hilus of the dentate gyrus is one of the most consistent morphological findings in humans with temporal lobe epilepsy and related models of acquired epilepsy...
  30. Cognitive Abilities of At-Risk Elderly for Dementia
    Mark W Bondi; Fiscal Year: 2012
    ..Young-Old and Very-Old, (c) to use combined ASL/BOLD FMRI to measure functional changes within the medial temporal lobe (MTL) and related structures (e.g...
  31. Subcortical control of neocortical slowing during focal hippocampal seizures
    JOSHUA ETHAN MOTELOW; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is characterized by focal seizures arising from limbic structures including the hippocampus...
  32. The Effects of Prenatal Stress &Poor Nutrition on Brain and Cognition
    Bradley S Peterson; Fiscal Year: 2013
    ..mental and motor development on the Bayley Scales in infancy, and a reduction in gray matter in the middle temporal lobe based on brain imaging in school-age children...
  33. In vivo magnetic resonance-based analysis of inherited neurologic disease after g
    HEATHER G EDWARDS; Fiscal Year: 2013
    ..gangliosidosis brain, will be measured in each cat at the level of thalamus, frontal cortex, occipital lobe, temporal lobe and cerebellum...
  34. Molecular Determinants of GABAA Receptor Gene Regulation
    SHELLEY JUNE RUSSEK; Fiscal Year: 2010
    ..transmission, however, it is not known whether the changes in GABAR properties seen in animal models of temporal lobe epilepsy (TIE) are either necessary or sufficient for epileptogenesis...
  35. Genetic Study of Common Forms of Epilepsy
    HAKON contact HAKONARSON; Fiscal Year: 2010
    ..CAE) and idiopathic epilepsy not otherwise specified (IGE-NOS) and ii) forms of localized epilepsy including temporal lobe epilepsy (TLE) and cryptogenic focal epilepsy (CFE)...
  36. CELLULAR INFORMATION PROCESSING IN THE HIPPOCAMPUS
    Daniel Johnston; Fiscal Year: 2013
    ..In animal models for temporal lobe epilepsy (TLE), we found a significant reduction in dendritic K+ and h channels, and recently we showed that a ..
  37. Mechanisms of Memory Enhancement by Deep Brain Stimulation in Humans
    Itzhak Fried; Fiscal Year: 2013
    ..It is present in various neurological disorders including temporal lobe epilepsy, traumatic brain injury and other hippocampal injuries such as those occurring during stroke, cardiac ..
  38. Evaluation of Scn8a as a target for the treatment of refractory epilepsy
    CHRISTOPHER DONALD MAKINSON; Fiscal Year: 2013
    ..Aim 2 will determine the effect of reducing Scn8a expression in a mouse model of temporal lobe epilepsy (TLE), the most common form of refractory epilepsy...
  39. Decision Support System for Temporal Lobe Epilepsy
    Hamid Soltanian-Zadeh; Fiscal Year: 2013
    ..and compared to other methods for the segmentation of specific brain structures that may be involved in medial temporal lobe epilepsy (mTLE). Feature extraction methods also need to be developed and optimized to characterize (i.e...
  40. Seizure-Induced Plasticity of the Ia Current in the Entorhinal Cortex
    STEPHANIE CARLSON; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Seizures associated with medial temporal lobe epilepsy (TLE) damage structures in the limbic region of the brain, including the hippocampus, entorhinal cortex (EC), and amygdala...
  41. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul S Buckmaster; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy is common and difficult to treat. Our long-range research goal is to help reveal mechanisms of temporal lobe epilepsy and develop anti-epileptogenic strategies...
  42. Radiosurgery vs lobectomy for temporal lobe epilepsy: Phase 3 Clinical Trial
    Nicholas M Barbaro; Fiscal Year: 2012
    ..Patients with unilateral temporal lobe seizure onsets have an excellent chance of becoming seizure-free following temporal lobectomy...
  43. Amyloid Imaging, VMCI, and Analysis for ADNI
    Michael W Weiner; Fiscal Year: 2010
    ..accompanied by reduced brain glucose metabolism (assessed by FDG-PET) and an increased rate of medial temporal lobe atrophy, and 3) after the aforementioned events, memory impairment appears, eventually progressing to dementia...
  44. Diverse Roles of Adult Dentate Gyrus Neurogenesis
    Helen E Scharfman; Fiscal Year: 2013
    ..It also has been suggested that adult neurogenesis plays a role in temporal lobe epilepsy (TLE) where seizures involve the DG...
  45. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2013
    ..3) Is upregulation of HCN gating via activation of p38 MAPK signaling effective in an animal model of temporal lobe epilepsy (TLE)? To answer these questions, we will use cellular electrophysiology techniques in the brain ..
  46. Dysregulation of Glutamine Synthetase in Human Temporal Lobe Epilepsy
    Tore Eid; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Dysregulation of Glutamine Synthetase in Human Temporal Lobe Epilepsy: The main objective of this K08 proposal is to facilitate the applicant's development towards independence as a physician-..
  47. High Resolution Magnetic Resonance Imaging and Spectroscopy of Epilepsy at 7T
    Priti Balchandani; Fiscal Year: 2012
    ..of the brain at 7T, 2) develop tools for high spatial-resolution proton spectroscopic imaging of the medial temporal lobe at 7T and 3) combine these tools to com- pose a comprehensive 7T epilepsy imaging protocol which we will ..
  48. Proneurotrophin signaling in epilepsy
    AJAY THOMAS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is a neurological disease that is characterized by recurrent unprovoked seizures...
  49. Calcium Signaling in Astrocytes
    KAREN S contact WILCOX; Fiscal Year: 2010
    ..the proposed work is to develop novel technical and theoretical means to understand the mechanisms underlying temporal lobe epilepsy (TLE) and to assess new classes of possible treatments for this devastating disorder...
  50. Sleep Disordered Breathing in normal elderly and risk for Alzheimers Disease
    Ricardo S Osorio; Fiscal Year: 2013
    ..with the increase of CSF P-Tau and T-Tau, a decrease in glucose uptake (measured by FDG-PET) in the medial temporal lobe, reduced hippocampal volume, and longitudinal memory decline...
  51. REGULATION OF EXTRACELLULAR EXCITOTOXINS
    MICHAEL BYRNE ROBINSON; Fiscal Year: 2012
    ..the hypothesis that both of these regulatory mechanisms are increased in the hippocampus of an animal model of temporal lobe epilepsy (Aim III)...
  52. Functional Architecture of Human Speech Motor Cortex
    Edward Chang; Fiscal Year: 2011
    ..Our research focuses on novel methodologies gained in previous studies of speech perception in the human temporal lobe. We wish to broaden the impact of our research and innovate a related, and highly complementary field in the ..
  53. Interictal discharge events: from physiological effects to cognitive consequences
    Gabriel Kreiman; Fiscal Year: 2012
    ..Our proposal aims to understand how the neuronal circuits in the medial temporal lobe (MTL) responsible for learning are affected by clinical and subclinical manifestations of epilepsy...
  54. Molecular Determinants of Mossy Fiber Presynaptic Channelopathies in Epilepsy
    EMILIO RAFAEL GARRIDO SANABRIA; Fiscal Year: 2010
    ..The hippocampal mossy fibers undergo molecular and structural rearrangement in human and experimental mesial temporal lobe epilepsy (MTLE)...
  55. Neural Grafts and Injury-Induced Hippocampal Dysfunction
    Ashok K Shetty; Fiscal Year: 2010
    ..F344 rats undergoing intraperitoneal kainic acid induced acute seizures and hippocampal injury, a model of temporal lobe epilepsy...
  56. HCN Channel Trafficking in Epilepsy
    Dane M Chetkovich; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE) is a common cause of refractory seizures. Increased seizure propensity in TLE is caused by abnormal neuronal excitability...
  57. IN VIVO STUDIES OF THE EPILEPTIC HIPPOCAMPUS
    JEROME NONE ENGEL; Fiscal Year: 2013
    ..We now have acquired evidence from several chronic rat models of human mesial temporal lobe epilepsy (MTLE), and from patients with MTLE, suggesting that pHFOs are generated by discrete neuronal ..
  58. Consequences of Prolonged Febrile Seizures in Childhood
    Shlomo Shinnar; Fiscal Year: 2013
    ..relationship between FSE, hippocampal atrophy, hippocampal sclerosis (HS), and the development of subsequent temporal lobe epilepsy (TLE) and cognitive impairment...
  59. Frontal Lobe Neuroimaging as a Biomarker of Chronic Traumatic Encephalopathy
    JULIE MARIE STAMM; Fiscal Year: 2012
    ..will e used to examine the uncinate fasciculus, a white matter tract connecting the prefrontal cortex and temporal lobe, and the genu of the corpus callosum, a white matter pathway connecting the right and left prefrontal cortices...
  60. The Effect of Anticipation on Episodic Memory: Motivation and Attention
    SASHA MONICA WOLOSIN; Fiscal Year: 2012
    ..Episodic memory-memory for specific events-critically relies on the integrity of the structures of the medial temporal lobe (MTL), including the hippocampus (CA fields, dentate gyrus, and subiculum) and parahippocampal gyrus (..
  61. CELLULAR CHANGES ALTERING SYNAPTIC CONNECTIVITY IN PRECLINICAL AD
    Stephen W Scheff; Fiscal Year: 2013
    ..Increasing evidence suggests that the medial temporal lobe (MTL) is the earliest regions of the brain affected and may provide important clues to the progression of the ..
  62. A Novel Mouse Model of Temporal Lobe Epilepsy
    Karen S Wilcox; Fiscal Year: 2013
    ....
  63. A Model of Early Alzheimer Disease
    Bradley T Hyman; Fiscal Year: 2012
    ..As the disease progresses, disruption of these pathways and closely related structures in the medial temporal lobe are believed to explain why memory impairments so dominate the clinical symptoms of AD...
  64. High frequency activity in infants with epilepsy
    JULIA MARIE STEPHEN; Fiscal Year: 2010
    ..fast ripple (FR), superimposed on interictal spikes is a biomarker of epileptogenesis in adults with mesial temporal lobe epilepsy...
  65. Astrocytes and temporal lobe epilepsy
    KAREN WILCOX; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Temporal lobe epilepsy (TLE), a devastating seizure disorder that is difficult to control with anticonvulsant drugs, often develops following an initial insult to the CNS...
  66. Rat transcriptome biomarkers for the prediction of temporal lobe epilepsy
    STANISLAV KARSTEN; Fiscal Year: 2009
    ..neurodegeneration and synaptic reorganization that ultimately may, or may not lead to the development of temporal lobe epilepsy (TLE)...
  67. ENDOGENOUS DYNORPHIN OPIOIDS AND TEMPORAL LOBE EPILEPSY
    Charles Chavkin; Fiscal Year: 1999
    ..Second, that in both human and animal models of temporal lobe epilepsy, there is often an expansion of the dynorphin-containing fibers in the dentate gyrus as a consequence ..
  68. BIOLOGICAL BASIS OF SCHIZOTYPAL PERSONALITY DISORDER
    ROBERT MC CARLEY; Fiscal Year: 2009
    ..generally less prominent in women;2) abnormalities in SPD are likely to be primarily referable to temporal lobe systems {auditory &language processing) and to the frontal-striato-thalamic system (FST, working memory, ..
  69. Progression of temporal lobe epilepsy
    F Edward Dudek; Fiscal Year: 2007
    Although epidemiological studies have provided valuable perspectives on temporal lobe epilepsy, the ethical limitations of human research prevent a definitive answer to the important question: is antiepileptic drug (AED) therapy purely ..
  70. TEMPORAL LOBE INPUT TO THE DESCENDING MOTOR PATHWAYS
    ROBERT MORECRAFT; Fiscal Year: 2001
    ..of this research is to characterize functional pathways that connect several limbic-affiliated parts of the temporal lobe with physiologically mapped body representations of the motor cortex which, in turn, directly influence ..
  71. Frontal/Medial Temporal Lobe Contributions to Memory
    Jeffrey Ojemann; Fiscal Year: 2005
    ..The evaluation of medial temporal lobe function is necessary prior to temporal lobectomy for epilepsy to avoid postoperative amnesia...
  72. MRS LOCALIZATION OF ADULTS/PEDIATRIC EPILEPTIC FOCI
    THIAN NG; Fiscal Year: 2002
    ..magnetic resonance spectroscopic imaging (MRSI) in patients with drug-refractory surgically treatable focal temporal lobe epilepsy (TLE) to determine if MRSI spectra of localized abnormal brain metabolites are associated with: 1) ..
  73. MRI OF STRUCTURE/FUNCTION IN TEMPORAL LOBE EPILEPSY
    John Detre; Fiscal Year: 2003
    ..In patients with refractory temporal lobe epilepsy (TLE), temporal lobectomy is beneficial, resulting in better seizure control, better integration into ..
  74. NEUROLOGY OF MEMORY
    Stuart Zola; Fiscal Year: 2002
    ..an animal model of amnesia in the monkey and in identifying the anatomical components of the medial temporal lobe memory system...