somatosensory cortex

Summary

Summary: Area of the parietal lobe concerned with receiving general sensations. It lies posterior to the central sulcus.

Top Publications

  1. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
  2. ncbi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
  3. ncbi Activity-dependent development of callosal projections in the somatosensory cortex
    Chun Lei Wang
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 27:11334-42. 2007
  4. ncbi Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex
    Joachim Lubke
    Research Centre Julich, Institute of Neurosciences and Biophysics INB 3, Leo Brandt Str, 52425 Julich, Germany
    Brain Struct Funct 212:3-17. 2007
  5. pmc Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
    Christoph Kapfer
    Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 10:743-53. 2007
  6. pmc Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
    Carl C H Petersen
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg D 69120, Germany
    Proc Natl Acad Sci U S A 100:13638-43. 2003
  7. ncbi Gamma-band oscillations in the primary somatosensory cortex--a direct and obligatory correlate of subjective pain intensity
    Z G Zhang
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 32:7429-38. 2012
  8. ncbi Somatosensation in social perception
    Christian Keysers
    Social Brain Laboratory, Department of Neuroscience, University Medical Center Groningen, A Deusinglaan 2, 9713AW Groningen, The Netherlands
    Nat Rev Neurosci 11:417-28. 2010
  9. ncbi Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
    Leopoldo Petreanu
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, Virginia 20147, USA
    Nat Neurosci 10:663-8. 2007
  10. ncbi Long-range neuronal circuits underlying the interaction between sensory and motor cortex
    Tianyi Mao
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 72:111-23. 2011

Research Grants

  1. CORTICAL CONTROL OF MOVEMENT
    Asaf Keller; Fiscal Year: 2010
  2. The organization and plasticity of cortical areas representing the dentition
    KENNETH CATANIA; Fiscal Year: 2009
  3. Plasticity of the Visual Cortex
    Stelios Smirnakis; Fiscal Year: 2006
  4. Cortical Representational Plasticity of Oral Structures
    KENNETH CATANIA; Fiscal Year: 2003
  5. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
  6. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
  7. Local Circuit Properties of Mouse Corticospinal Neurons
    Patrick L Sheets; Fiscal Year: 2011
  8. PDZ DOMAINS AND AMPA RECEPTOR FUNCTION
    Richard L Huganir; Fiscal Year: 2013
  9. NG2 cell dynamics in the normal and injured adult central nervous system
    Ethan Hughes; Fiscal Year: 2012
  10. Mapping the Inputs onto Neocortical Chandelier Cells
    Jason M Tucciarone; Fiscal Year: 2013

Detail Information

Publications360 found, 100 shown here

  1. ncbi CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury
    T Schallert
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Mezes 330, Austin, TX 78712, USA
    Neuropharmacology 39:777-87. 2000
    ..OP-1 showed a beneficial effect on limb use asymmetry in the cylinder test...
  2. ncbi The excitatory neuronal network of the C2 barrel column in mouse primary somatosensory cortex
    Sandrine Lefort
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne, CH1015, Switzerland
    Neuron 61:301-16. 2009
    ..synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex. This cortical column is known to process tactile information related to the C2 whisker...
  3. ncbi Activity-dependent development of callosal projections in the somatosensory cortex
    Chun Lei Wang
    Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    J Neurosci 27:11334-42. 2007
    ..activity is necessary for the normal development and maintenance of callosal projections in the mouse somatosensory cortex. We labeled a subpopulation of layer II/III callosal neurons via in utero electroporation and traced their ..
  4. ncbi Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex
    Joachim Lubke
    Research Centre Julich, Institute of Neurosciences and Biophysics INB 3, Leo Brandt Str, 52425 Julich, Germany
    Brain Struct Funct 212:3-17. 2007
    ..In the last decade the 'barrel' field in the rodent somatosensory cortex, which processes sensory information arriving from the mysticial vibrissae, has become a quite attractive ..
  5. pmc Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex
    Christoph Kapfer
    Neuroscience Graduate Program and Neurobiology Section, Division of Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0634, USA
    Nat Neurosci 10:743-53. 2007
    ..We show here that the activity of even a single layer 2/3 pyramidal cell in the somatosensory cortex of the rat generates widespread inhibition that increases disproportionately with the number of active ..
  6. pmc Interaction of sensory responses with spontaneous depolarization in layer 2/3 barrel cortex
    Carl C H Petersen
    Department of Cell Physiology, Max Planck Institute for Medical Research, Jahnstrasse 29, Heidelberg D 69120, Germany
    Proc Natl Acad Sci U S A 100:13638-43. 2003
    The rodent primary somatosensory cortex is spontaneously active in the form of locally synchronous membrane depolarizations (UP states) separated by quiescent hyperpolarized periods (DOWN states) both under anesthesia and during quiet ..
  7. ncbi Gamma-band oscillations in the primary somatosensory cortex--a direct and obligatory correlate of subjective pain intensity
    Z G Zhang
    Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 32:7429-38. 2012
    Electroencephalographic gamma band oscillations (GBOs) induced over the human primary somatosensory cortex (SI) by nociceptive stimuli have been hypothesized to reflect cortical processing involved directly in pain perception, because ..
  8. ncbi Somatosensation in social perception
    Christian Keysers
    Social Brain Laboratory, Department of Neuroscience, University Medical Center Groningen, A Deusinglaan 2, 9713AW Groningen, The Netherlands
    Nat Rev Neurosci 11:417-28. 2010
    ..Neuroscientists are starting to understand how the brain adds a somatosensory dimension to our perception of other people...
  9. ncbi Channelrhodopsin-2-assisted circuit mapping of long-range callosal projections
    Leopoldo Petreanu
    Howard Hughes Medical Institute, Janelia Farm Research Campus, 19700 Helix Drive, Ashburn, Virginia 20147, USA
    Nat Neurosci 10:663-8. 2007
    ..ChR2-assisted circuit mapping (CRACM), to map long-range callosal projections from layer (L) 2/3 of the somatosensory cortex. L2/3 axons connect with neurons in L5, L2/3 and L6, but not L4, in both ipsilateral and contralateral ..
  10. ncbi Long-range neuronal circuits underlying the interaction between sensory and motor cortex
    Tianyi Mao
    Janelia Farm Research Campus, HHMI, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 72:111-23. 2011
    ..The cortico-cortical neurons in superficial layers of motor cortex thus couple motor and sensory signals and might mediate sensorimotor integration and motor learning...
  11. ncbi Corticocortical connections of visual, sensorimotor, and multimodal processing areas in the parietal lobe of the macaque monkey
    J W Lewis
    California Institute of Technology, Pasadena, California 16825, USA
    J Comp Neurol 428:112-37. 2000
    ..They also support and extend previous evidence for multiple distributed networks that are implicated in multimodal integration, especially with regard to area VIP...
  12. ncbi Behaviour-dependent recruitment of long-range projection neurons in somatosensory cortex
    Jerry L Chen
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nature 499:336-40. 2013
    ..of distinct, largely non-overlapping long-range projection neurons in the whisker region of primary somatosensory cortex (S1) in awake, behaving mice...
  13. pmc The observation and execution of actions share motor and somatosensory voxels in all tested subjects: single-subject analyses of unsmoothed fMRI data
    Valeria Gazzola
    University Medical Center Groningen, University of Groningen, Department of Neuroscience, Groningen, The Netherlands
    Cereb Cortex 19:1239-55. 2009
    ....
  14. ncbi Pain and plasticity: is chronic pain always associated with somatosensory cortex activity and reorganization?
    Sylvia M Gustin
    Discipline of Anatomy and Histology, University of Sydney, Sydney, New South Wales 2006, Australia
    J Neurosci 32:14874-84. 2012
    The somatosensory cortex remodels in response to sensory deprivation, with regions deprived of input invaded by neighboring representations...
  15. ncbi Functional expansion of sensorimotor representation and structural reorganization of callosal connections in lower limb amputees
    Elington L Simões
    Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil 21941 920
    J Neurosci 32:3211-20. 2012
    ..Finally, DTI analysis showed structural changes in the corpus callosum of amputees, compatible with the hypothesis that phantom sensations may depend on inhibitory release in the sensorimotor cortex...
  16. ncbi Motor control by sensory cortex
    Ferenc Matyas
    Laboratory of Sensory Processing, Brain Mind Institute, Faculty of Life Sciences, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Science 330:1240-3. 2010
    ..system, we found an additional and equally direct pathway for cortical motor control driven by the primary somatosensory cortex. Whereas activity in primary motor cortex directly evokes exploratory whisker protraction, primary ..
  17. pmc In vivo 3D morphology of astrocyte-vasculature interactions in the somatosensory cortex: implications for neurovascular coupling
    Addason F H McCaslin
    Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA
    J Cereb Blood Flow Metab 31:795-806. 2011
    ..of astrocytes and their interrelations with blood vessels down through layer IV of the mouse somatosensory cortex using in vivo two-photon microscopy...
  18. ncbi Psychological and neural mechanisms of the affective dimension of pain
    D D Price
    Department of Oral and Maxillofacial Surgery, University of Florida, Health Science Center, Post Office Box 100416, Gainesville, FL 32610 0416, USA
    Science 288:1769-72. 2000
    ..Both direct and cortico-limbic pathways converge on the same anterior cingulate cortical and subcortical structures whose function may be to establish emotional valence and response priorities...
  19. ncbi A touching sight: SII/PV activation during the observation and experience of touch
    Christian Keysers
    BCN Neuroimaging Centre, University of Groningen, 9713 AW Groningen, The Netherlands
    Neuron 42:335-46. 2004
    ..a similar mechanism applies to the sight of touch, movies depicting touch should automatically activate the somatosensory cortex of the observer...
  20. ncbi Functional diversity of layer IV spiny neurons in rat somatosensory cortex: quantitative morphology of electrophysiologically characterized and biocytin labeled cells
    Jochen F Staiger
    C and O Vogt Institute for Brain Research, Heinrich Heine University Dusseldorf, D 40001 Dusseldorf, Germany
    Cereb Cortex 14:690-701. 2004
    ..This offers a structural basis for either segregation or early context-dependent integration of tactile information, in a cell-type specific manner...
  21. pmc Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex
    T Iwasato
    Laboratory for Behavioral Genetics, Brain Science Institute, RIKEN, Saitama, Japan
    Nature 406:726-31. 2000
    In the rodent primary somatosensory cortex, the configuration of whiskers and sinus hairs on the snout and of receptor-dense zones on the paws is topographically represented as discrete modules of layer IV granule cells (barrels) and ..
  22. ncbi Human somatosensory area 2: observer-independent cytoarchitectonic mapping, interindividual variability, and population map
    C Grefkes
    C. and O. Vogt Brain Research Institute, , , Germany
    Neuroimage 14:617-31. 2001
    ..This microstructurally defined population map can be used to demonstrate activations of area 2 in functional imaging studies and therefore help to further understand the role of area 2 in somatosensory processing...
  23. ncbi Neural activity in barrel cortex underlying vibrissa-based object localization in mice
    Daniel H O'Connor
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive, Ashburn, VA 20147, USA
    Neuron 67:1048-61. 2010
    ..Approximately 13,000 spikes per activated barrel column were available to mice for decision making. Coding of object location in the barrel cortex is therefore highly redundant...
  24. ncbi Neocortex patterning by the secreted signaling molecule FGF8
    T Fukuchi-Shimogori
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Chicago, IL 60637, USA
    Science 294:1071-4. 2001
    ..These findings support a role for FGF signaling in specifying positional identity in the neocortex...
  25. pmc Functional role of exercise-induced cortical organization of sensorimotor cortex after spinal transection
    T Kao
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    J Neurophysiol 106:2662-74. 2011
    ..we chronically implanted arrays of microwire electrodes into the infragranular layers of the hindlimb somatosensory cortex of adult rats neonatally transected at T8/T9 that received exercise training (spinalized rats) and of ..
  26. pmc Seeing touch is correlated with content-specific activity in primary somatosensory cortex
    Kaspar Meyer
    Brain and Creativity Institute, University of Southern California, 3641 Watt Way, Suite 126, Los Angeles, CA 90089 2520, USA
    Cereb Cortex 21:2113-21. 2011
    ..modality; for instance, visual stimuli that imply touch have been observed to activate the primary somatosensory cortex (SI)...
  27. ncbi Digit-specific aberrations in the primary somatosensory cortex in Writer's cramp
    Aimee J Nelson
    Toronto Western Research Institute, University of Toronto, Toronto, Canada
    Ann Neurol 66:146-54. 2009
    ..a reduced distance between the representations of digits 1 and 5 and also digits 2 and 5 in primary somatosensory cortex. However, we lack information on the spatial relationships among digits, such as reduced inter-digit ..
  28. pmc Targeted mini-strokes produce changes in interhemispheric sensory signal processing that are indicative of disinhibition within minutes
    Majid H Mohajerani
    Department of Psychiatry and Brain Research Center, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Proc Natl Acad Sci U S A 108:E183-91. 2011
    ..Blockade of a single pial arteriole within the C57BL6J mouse forelimb somatosensory cortex reduced the response evoked by stimulation of the limb contralateral to the stroke...
  29. ncbi Spatiotemporal dynamics of cortical sensorimotor integration in behaving mice
    Isabelle Ferezou
    Laboratory of Sensory Processing, Brain Mind Institute, Ecole Polytechnique Federale de Lausanne EPFL, Switzerland
    Neuron 56:907-23. 2007
    ..Sensory processing in motor cortex may therefore contribute significantly to active tactile sensory perception...
  30. ncbi Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo
    Sooyoung Chung
    Department of Biology and, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 34:437-46. 2002
    ..These data strongly suggest that synaptic depression of thalamic input to the cortex contributes to the dynamic regulation of neuronal sensitivity during rapid changes in sensory input...
  31. pmc Input-specific critical periods for experience-dependent plasticity in layer 2/3 pyramidal neurons
    Jing A Wen
    Department of Biological Sciences and Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 31:4456-65. 2011
    ..we show that rapid experience-dependent changes in the strength of excitatory synapses within mouse primary somatosensory cortex exhibit a critical period that is input specific and mechanistically distinct in layer 2/3 pyramidal ..
  32. pmc Presynaptic development at L4 to l2/3 excitatory synapses follows different time courses in visual and somatosensory cortex
    Claire E J Cheetham
    School of Biosciences, Cardiff University, Cardiff CF10 3AX, United Kingdom
    J Neurosci 30:12566-71. 2010
    ....
  33. ncbi Responses of infragranular neurons in the rat primary somatosensory cortex to forepaw and hindpaw tactile stimuli
    K A Moxon
    School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA 19104, USA
    Neuroscience 156:1083-92. 2008
    Infragranular layers constitute the main output of the primary somatosensory cortex and represent an important stage of cortico-cortical and cortico-subcortical integration...
  34. ncbi Gain modulation from background synaptic input
    Frances S Chance
    Center for Neural Science, New York University, New York, NY 10003, USA
    Neuron 35:773-82. 2002
    ..synaptic conductances that mimics conditions encountered in vivo into pyramidal neurons in slices of rat somatosensory cortex, we show that the gain of a neuronal response to excitatory drive can be modulated by varying the level of &..
  35. ncbi Map plasticity in somatosensory cortex
    Daniel E Feldman
    Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, Room 0357, La Jolla, CA 92093, USA
    Science 310:810-5. 2005
    Sensory maps in neocortex are adaptively altered to reflect recent experience and learning. In somatosensory cortex, distinct patterns of sensory use or disuse elicit multiple, functionally distinct forms of map plasticity...
  36. ncbi The human parietal operculum. II. Stereotaxic maps and correlation with functional imaging results
    Simon B Eickhoff
    Institute of Medicine, Research Center Julich, 52425 Julich, Germany
    Cereb Cortex 16:268-79. 2006
    ..and relate these anatomically defined cortical areas to the location of the functionally defined secondary somatosensory cortex (SII cortex) using a meta-analysis of functional imaging results...
  37. pmc Shifts in coding properties and maintenance of information transmission during adaptation in barrel cortex
    Miguel Maravall
    Instituto de Neurociencias de Alicante UMH CSIC, Campus de San Juan, Sant Joan d Alacant, Spain
    PLoS Biol 5:e19. 2007
    ..Our results suggest that adaptation enhances tactile representations in primary somatosensory cortex, where they could directly influence perceptual decisions.
  38. pmc Primary motor cortex reports efferent control of vibrissa motion on multiple timescales
    DANIEL N HILL
    Computational Neuroscience Graduate Program, University of California, San Diego, San Diego, CA 92093, USA
    Neuron 72:344-56. 2011
    ....
  39. ncbi Empathy for pain and touch in the human somatosensory cortex
    Ilaria Bufalari
    Dipartimento di Psicologia, Universita degli Studi di Roma La Sapienza, I 00185, Rome, Italy
    Cereb Cortex 17:2553-61. 2007
    ..increased and decreased the amplitude of the P45 SEP component that reflects the activity of the primary somatosensory cortex (S1)...
  40. ncbi Sensorimotor integration in movement disorders
    Giovanni Abbruzzese
    Dipartimento di Scienze Neurologiche e della Visione, Universita di Genova, Via de Tony 5, 16132 Genoa, Italy
    Mov Disord 18:231-40. 2003
    ..Although the physiological mechanism remains unclear, the defect is of special clinical relevance in determining the development of focal dystonia...
  41. ncbi Vision modulates somatosensory cortical processing
    Marisa Taylor-Clarke
    Institute of Cognitive Neuroscience and Department of Psychology, University College London, 17, Queen Square, London WC1N 3AR, United Kingdom
    Curr Biol 12:233-6. 2002
    ..Here, we show that vision modulates somatosensory cortex activity, as measured by somatosensory event-related potentials (ERPs)...
  42. ncbi Somatosensory cortical neuronal population activity across states of anaesthesia
    Irina A Erchova
    Cognitive Neuroscience Sector, International School for Advanced Studies, Via Beirut, 9, 34014 Trieste, Italy
    Eur J Neurosci 15:744-52. 2002
    ..The possible significance of the cyclic cortical responsiveness encountered during urethane anaesthesia to cortical processing in awake rats is considered...
  43. pmc Synaptic connections between layer 4 spiny neurone-layer 2/3 pyramidal cell pairs in juvenile rat barrel cortex: physiology and anatomy of interlaminar signalling within a cortical column
    Dirk Feldmeyer
    Max Planck Institut fur medizinische Forschung, Abteilung Zellphysiologie, Jahnstrasse 29, D 69120 Heidelberg, Germany
    J Physiol 538:803-22. 2002
    ..synaptically coupled excitatory layer 4 (L4) spiny neurones and L2/3 pyramidal cells in acute slices of the somatosensory cortex ('barrel' cortex) of 17- to 23-days-old rats...
  44. ncbi Formation of dendritic spines with GABAergic synapses induced by whisker stimulation in adult mice
    Graham W Knott
    Institut de Biologie Cellulaire et Morphologie, Universite de Lausanne, Rue du Bugnon 9, CH 1005, Lausanne, Switzerland
    Neuron 34:265-73. 2002
    ..These results indicate activity-dependent alterations in synaptic circuitry in adulthood, modifying the flow of sensory information into the cerebral cortex...
  45. ncbi Choice of cranial window type for in vivo imaging affects dendritic spine turnover in the cortex
    Hua Tai Xu
    Molecular Neurobiology Program, Skirball Institute, Department of Physiology and Neuroscience, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Neurosci 10:549-51. 2007
    ..These findings help to explain existing discrepancies in the degree of dendritic spine plasticity observed in the mature cortex...
  46. ncbi More than skin deep: body representation beyond primary somatosensory cortex
    Matthew R Longo
    Institute of Cognitive Neuroscience, University College London, London, UK
    Neuropsychologia 48:655-68. 2010
    ..We review a wide range of neuropsychological, neuroimaging and neurophysiological data to explore the dissociation between these different aspects of higher somatosensory function...
  47. pmc Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex
    Hanno S Meyer
    Department of Cell Physiology, Max Planck Institute for Medical Research, D 69120 Heidelberg, Germany
    Cereb Cortex 20:2277-86. 2010
    ..determinants of thalamocortical (TC) input to excitatory neurons in a cortical column of rat primary somatosensory cortex (S1)...
  48. ncbi Vibrissa-based object localization in head-fixed mice
    Daniel H O'Connor
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    J Neurosci 30:1947-67. 2010
    ..Mice tended to maximize contact with the go (rewarded) stimulus while minimizing contact with the no-go stimulus. We conjecture that this may amplify differences in evoked neural activity between trial types...
  49. pmc Dynamic representation of whisker deflection by synaptic potentials in spiny stellate and pyramidal cells in the barrels and septa of layer 4 rat somatosensory cortex
    Michael Brecht
    Abteilung Zellphysiologie, Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    J Physiol 543:49-70. 2002
    ..This presumably reflects the divergence of thalamocortical projections to different barrels. Septum cell PSPs preferably represent multiple whisker deflections, but less dynamically and with less spatial acuity...
  50. ncbi Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex
    Ernst Seiffert
    Johannes Muller Institute of Physiology, Charite, University Medicine, 10117 Berlin, Germany
    J Neurosci 24:7829-36. 2004
    ..Although many neuropathologies entail a compromised blood-brain barrier, this is the first direct evidence that it may have a role in the pathogenesis of focal cortical epilepsy, a common neurological disease...
  51. ncbi Human secondary somatosensory cortex is involved in the processing of somatosensory rare stimuli: an fMRI study
    Tzu Ling Chen
    Department of Clinical Sciences and Bio imaging, University of Chieti, Italy
    Neuroimage 40:1765-71. 2008
    In the human somatosensory system, the contralateral primary somatosensory cortex (SI) is presumed to process and encode type and intensity of the sensory inputs, whereas the bilateral secondary somatosensory cortex (SII) is believed to ..
  52. ncbi Negative blood oxygen level dependence in the rat: a model for investigating the role of suppression in neurovascular coupling
    Luke Boorman
    Department of Psychology, University of Sheffield, Sheffield S10 2TN, United Kingdom
    J Neurosci 30:4285-94. 2010
    ..inhibitory neurovascular signals, the negative blood oxygen level-dependent (BOLD) response (NBR), in rat somatosensory cortex. We found a reliable NBR measured in rat somatosensory cortex in response to unilateral electrical whisker ..
  53. ncbi The human parietal operculum. I. Cytoarchitectonic mapping of subdivisions
    Simon B Eickhoff
    Institute of Medicine, Research Center Julich, 52425 Julich, Germany
    Cereb Cortex 16:254-67. 2006
    The human secondary somatosensory cortex (SII) is located on the parietal operculum, as shown by intraoperative stimulation and functional imaging studies...
  54. ncbi The role of the right parietal lobe in anorexia nervosa
    D Nico
    Dipartimento di Psicologia, Universita La Sapienza, Rome, Italy
    Psychol Med 40:1531-9. 2010
    ..The possibility that parietal dysfunction might contribute to AN is suspected, based on the demonstrated association of spatial impairments, comparable to those found after parietal lesion, with this syndrome...
  55. pmc Spinal direct current stimulation modulates the activity of gracile nucleus and primary somatosensory cortex in anaesthetized rats
    J Aguilar
    Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain
    J Physiol 589:4981-96. 2011
    ..point for hindpaw somatosensory signals reaching the brain from the dorsal columns, and of the primary somatosensory cortex in anaesthetized rats...
  56. ncbi The functional organization of the barrel cortex
    Carl C H Petersen
    Laboratory of Sensory Processing, Brain Mind Institute, SV BMI LSENS, Station 15, Ecole Polytechnique Federale de Lausanne EPFL, CH 1015 Lausanne, Switzerland
    Neuron 56:339-55. 2007
    ..The primary somatosensory cortex has an exquisite somatotopic map where each individual whisker is represented in a discrete anatomical unit,..
  57. pmc Fine-grained nociceptive maps in primary somatosensory cortex
    Flavia Mancini
    Institute of Cognitive Neuroscience, University College London, London WC1N 3AR, United Kingdom
    J Neurosci 32:17155-62. 2012
    ..we reveal the existence of fine-grained somatotopy for nociceptive inputs to the digits in human primary somatosensory cortex (SI)...
  58. pmc Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury
    Jenna M Ziebell
    Department of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, AZ, USA
    J Neuroinflammation 9:247. 2012
    ..Here, we describe the time course, location, and surrounding architecture associated with rod microglia following experimental diffuse traumatic brain injury (TBI)...
  59. ncbi Differential activation in somatosensory cortex for different discrimination tasks
    C Braun
    Institute of Medical Psychology and Behavioral Neurobiology, University of Tubingen, D 72074 Tubingen, Germany
    J Neurosci 20:446-50. 2000
    Maps of the body surface in somatosensory cortex have been shown to be highly plastic, altering their configuration in response to changes in use of body parts...
  60. pmc Theta-burst stimulation-induced plasticity over primary somatosensory cortex changes somatosensory temporal discrimination in healthy humans
    Antonella Conte
    IRCCS Neuromed Institute, Pozzilli Is, Italy
    PLoS ONE 7:e32979. 2012
    ..Precisely how the single cerebral structures contribute in controlling the STDT is partially known and no information is available about whether STDT can be modulated by plasticity-inducing protocols...
  61. ncbi Neonatal fluoxetine exposure affects the neuronal structure in the somatosensory cortex and somatosensory-related behaviors in adolescent rats
    Li Jen Lee
    Department of Anatomy, College of Medicine, National Taiwan University, No 1, Ren Ai Rd, Section 1, Taipei 100, Taiwan
    Neurotox Res 15:212-23. 2009
    ..Morphological features of the primary somatosensory cortex were checked at P7 and P35...
  62. pmc Large-scale organization of rat sensorimotor cortex based on a motif of large activation spreads
    Ron D Frostig
    Department of Neurobiology and Behavior, The Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 4550, USA
    J Neurosci 28:13274-84. 2008
    ..rat, stimulation of single whiskers evokes peak activity at topographically appropriate locations within somatosensory cortex and provides an example of cortical functional specificity...
  63. ncbi Development of layer-specific axonal arborizations in mouse primary somatosensory cortex
    DeLaine D Larsen
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Comp Neurol 494:398-414. 2006
    ..labeled and reconstructed the axons of layer 2/3 and layer 5 pyramidal neurons in slices of primary somatosensory cortex from C57Bl6 mice on postnatal days 7-21...
  64. ncbi Somatosensory cortex of prosimian Galagos: physiological recording, cytoarchitecture, and corticocortical connections of anterior parietal cortex and cortex of the lateral sulcus
    Carolyn W H Wu
    Department of Psychology, Vanderbilt University, Nashville, Tennessee 37240, USA
    J Comp Neurol 457:263-92. 2003
    Compared with our growing understanding of the organization of somatosensory cortex in monkeys, little is known about prosimian primates, a major branch of primate evolution that diverged from anthropoid primates some 60 million years ago...
  65. pmc Anatomical, physiological and molecular properties of Martinotti cells in the somatosensory cortex of the juvenile rat
    Yun Wang
    Division of Neurology Research, St Elizabeth s Medical Center, Tufts University, Boston, MA 02135, USA
    J Physiol 561:65-90. 2004
    ..and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical, electrophysiological and molecular ..
  66. ncbi Extensive reorganization of primary somatosensory cortex in chronic back pain patients
    H Flor
    Department of Psychology, Humboldt University, Berlin, Germany
    Neurosci Lett 224:5-8. 1997
    The hypothesis of reorganization of the primary somatosensory cortex in states of chronic pain was assessed in 10 low back pain patients and nine matched healthy controls...
  67. ncbi Transient and persistent dendritic spines in the neocortex in vivo
    Anthony J G D Holtmaat
    Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Neuron 45:279-91. 2005
    ..In the somatosensory cortex, from postnatal day (PND) 16 to PND 25 spine retractions exceeded additions, resulting in a net loss of ..
  68. pmc A beta2-frequency (20-30 Hz) oscillation in nonsynaptic networks of somatosensory cortex
    Anita K Roopun
    Medical School, University of Newcastle, Newcastle NE2 4HH, United Kingdom
    Proc Natl Acad Sci U S A 103:15646-50. 2006
    ..The oscillation period is determined by the M type of K+ current...
  69. ncbi Distributed representation of vibrissa movement in the upper layers of somatosensory cortex revealed with voltage-sensitive dyes
    D Kleinfeld
    Biological Computation Research Department, Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey 07974, USA
    J Comp Neurol 375:89-108. 1996
    ..We suggest that these patterns of activity are a manifestation of the dynamic interaction among neighboring cortical columns...
  70. ncbi Diverse types of interneurons generate thalamus-evoked feedforward inhibition in the mouse barrel cortex
    J T Porter
    Department of Neurobiology and Anatomy and the Sensory Neuroscience Research Center, West Virginia University, Morgantown, West Virginia 26506-9128, USA
    J Neurosci 21:2699-710. 2001
    ..We conclude that feedforward inhibition is generated by diverse classes of interneurons, possibly serving different roles in the processing of incoming sensory information...
  71. pmc Neuronal oscillations and multisensory interaction in primary auditory cortex
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Neuron 53:279-92. 2007
    ..The timing and laminar profile of the multisensory interactions in A1 indicate that nonspecific thalamic systems may play a key role in the effect...
  72. pmc Beta oscillations in a large-scale sensorimotor cortical network: directional influences revealed by Granger causality
    Andrea Brovelli
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
    Proc Natl Acad Sci U S A 101:9849-54. 2004
    ..In both monkeys, strong Granger causal influences were observed from primary somatosensory cortex to both motor cortex and inferior posterior parietal cortex, with the latter area also exerting Granger ..
  73. ncbi Geometric and functional organization of cortical circuits
    Gordon M G Shepherd
    Howard Hughes Medical Institute, Cold Spring Harbor, New York 11724, USA
    Nat Neurosci 8:782-90. 2005
    ..A large plasticity potential appears to be incorporated into these circuits, allowing for functional 'tuning' with fixed axonal and dendritic arbor geometry...
  74. pmc Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas
    B M Hooks
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia, United States of America
    PLoS Biol 9:e1000572. 2011
    ..and sensorimotor integration include the vibrissal area of the primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2)...
  75. ncbi Cortical sensory map rearrangement after spinal cord injury: fMRI responses linked to Nogo signalling
    Toshiki Endo
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Brain 130:2951-61. 2007
    ..stimulation was observed to enlarge and invade adjacent sensory-deprived hind limb territory in the primary somatosensory cortex as early as 3 days after injury...
  76. ncbi Cortical and subcortical contributions to activity-dependent plasticity in primate somatosensory cortex
    E G Jones
    Center for Neuroscience, University of California, Davis 95616, USA
    Annu Rev Neurosci 23:1-37. 2000
    After manipulations of the periphery that reduce or enhance input to the somatosensory cortex, affected parts of the body representation will contract or expand, often over many millimeters...
  77. pmc Dynamic receptive fields of reconstructed pyramidal cells in layers 3 and 2 of rat somatosensory barrel cortex
    Michael Brecht
    Department of Cell Physiology, Max Planck Institute for Medical Research, Heidelberg, Germany
    J Physiol 553:243-65. 2003
    ..We conclude that the lemniscal (barrel-related) and paralemniscal (septum-related) afferent inputs remain anatomically and functionally segregated in L2/3...
  78. ncbi Encoding of whisker vibration by rat barrel cortex neurons: implications for texture discrimination
    Ehsan Arabzadeh
    Cognitive Neuroscience Sector, International School for Advanced Studies, 34014 Trieste, Italy
    J Neurosci 23:9146-54. 2003
    ..What is the representation of texture in rat somatosensory cortex? We hypothesize that as rats "whisk" over a surface, the spatial frequency of a grooved or pebbled texture ..
  79. ncbi Large-scale sprouting of cortical connections after peripheral injury in adult macaque monkeys
    S L Florence
    Department of Psychology, Vanderbilt University, 301 Wilson Hall, Nashville, TN 37240, USA
    Science 282:1117-21. 1998
    ..to a forelimb, to determine whether the growth of new connections plays a role in the reorganization of somatosensory cortex that occurs after major alterations in peripheral somatosensory inputs...
  80. ncbi Effect of subthreshold up and down states on the whisker-evoked response in somatosensory cortex
    Robert N S Sachdev
    Department of Biology, University of Texas, San Antonio 78249 0662, USA
    J Neurophysiol 92:3511-21. 2004
    ..Different mechanisms are therefore responsible for the state-dependence of PSP amplitude and the spike frequency response to the whisker stimulus...
  81. pmc Spinal cord injury immediately changes the state of the brain
    Juan Aguilar
    Hospital Nacional de Paraplejicos, Servicio de Salud de Castilla La Mancha, Toledo, Spain
    J Neurosci 30:7528-37. 2010
    ..thoracic transection of the spinal cord produces immediate functional reorganization in the primary somatosensory cortex of anesthetized rats...
  82. pmc Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex
    Julien Chuquet
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:15298-303. 2010
    ....
  83. ncbi Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia
    Shengxiang Zhang
    Kinsmen Laboratory, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Neurosci 25:5333-8. 2005
    ..With severe ischemia, markedly deformed dendritic structure can partially recover if reperfusion occurs early...
  84. pmc Cued spatial attention drives functionally relevant modulation of the mu rhythm in primary somatosensory cortex
    Stephanie R Jones
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurosci 30:13760-5. 2010
    ..Further, while cued attention had a weaker effect on the allocation of mu-beta, oscillations in this band also predicted tactile detection...
  85. pmc Axonal dynamics of excitatory and inhibitory neurons in somatosensory cortex
    Sally A Marik
    Laboratory of Neurobiology, The Rockefeller University, New York, New York, United States of America
    PLoS Biol 8:e1000395. 2010
    ..we imaged neurons, labeled with a genetically modified adeno-associated virus, in the intact mouse somatosensory cortex before and after whisker plucking...
  86. ncbi Coupling of total hemoglobin concentration, oxygenation, and neural activity in rat somatosensory cortex
    Anna Devor
    Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA
    Neuron 39:353-9. 2003
    ....
  87. ncbi Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons
    Qian Quan Sun
    Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:1219-30. 2006
    ..The ready activation of FS cells by TC inputs, coupled with powerful feedforward inhibition from these neurons, would profoundly influence sensory processing and constrain runaway excitation in vivo...
  88. pmc Mapping human somatosensory cortex in individual subjects with 7T functional MRI
    R M Sanchez-Panchuelo
    Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, UK
    J Neurophysiol 103:2544-56. 2010
    ..Mapping the detailed topography of somatosensory cortex, however, has proven to be more difficult...
  89. pmc Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice
    Albrecht Sigler
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, Brain Research Center, University of British Columbia, Vancouver, BC, Canada
    Proc Natl Acad Sci U S A 106:11759-64. 2009
    ..more rapidly through preexisting pathways, we examined patterns of sensory-evoked depolarization in mouse somatosensory cortex within hours after targeted stroke to a subset of the forelimb sensory map...
  90. ncbi Understanding others' feelings: the role of the right primary somatosensory cortex in encoding the affective valence of others' touch
    Nadia Bolognini
    Department of Psychology, University of Milano Bicocca, 20126 Milano, Italy
    J Neurosci 33:4201-5. 2013
    ..imaging studies in humans have shown the existence of a shared somatosensory representation in the primary somatosensory cortex (S1), putatively involved in understanding others' sensations (Keysers et al...
  91. pmc Cortical excitation and inhibition following focal traumatic brain injury
    Ming chieh Ding
    School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA
    J Neurosci 31:14085-94. 2011
    ..cortical compression using large-scale, multielectrode measurement of multiunit activity in primary somatosensory cortex in a sensory-evoked, in vivo animal model...
  92. ncbi Active sensing of target location encoded by cortical microstimulation
    Subramaniam Venkatraman
    Qualcomm Corporate R and D, San Diego, CA 92121, USA
    IEEE Trans Neural Syst Rehabil Eng 19:317-24. 2011
    ..This ability to deliver sensory percepts using cortical microstimulation in an active sensing system might have significant implications for the development of sensorimotor neuroprostheses...
  93. pmc Primary somatosensory cortex discriminates affective significance in social touch
    Valeria Gazzola
    Department of Neuroscience, University Medical Center Groningen, 9713 AW Groningen, The Netherlands
    Proc Natl Acad Sci U S A 109:E1657-66. 2012
    ..This suggests that current models may underestimate the role played by SI in the affective processing of social touch...
  94. ncbi Intracerebral study of gamma rhythm reactivity in the sensorimotor cortex
    William Szurhaj
    EA 2683, Service de Neurophysiologie Clinique, Hopital Salengro, CHRU, F 59037 Lille Cedex, France
    Eur J Neurosci 21:1223-35. 2005
    ..We therefore suggest that gamma oscillations in the 40-60-Hz band may support afferent sensory feedback to the sensorimotor cortex during the performance of movement...
  95. pmc Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo
    Jonathan M Cayce
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37203, USA
    Neuroimage 57:155-66. 2011
    ..01-0.55 J/cm(2), fiber size=400 μm, repetition rate=50-200 Hz) was used to stimulate the somatosensory cortex of anesthetized rats, and its efficacy was assessed using intrinsic optical imaging and electrophysiology ..
  96. ncbi Selective serotonin reuptake inhibitor disrupts organization of thalamocortical somatosensory barrels during development
    Yanling Xu
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, Indianapolis, IN 46202, USA
    Brain Res Dev Brain Res 150:151-61. 2004
    ..refinement, but not the formation, of barrel-like clusters of thalamocortical fibers and that the development of neural circuitry in rodent somatosensory cortex was affected by exposure to a SSRI during thalamocortical synaptic formation.
  97. pmc Limb-state information encoded by peripheral and central somatosensory neurons: implications for an afferent interface
    Douglas J Weber
    Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA
    IEEE Trans Neural Syst Rehabil Eng 19:501-13. 2011
    ..investigate two possible strategies: electrical stimulation of either dorsal root ganglia (DRG) or primary somatosensory cortex (S1)...
  98. ncbi Attenuation of somatosensory responses to self-produced tactile stimulation
    Maike D Hesse
    Brain Research Unit, Low Temperature Laboratory, Helsinki University of Technology, 02015 TKK Espoo, Finland
    Cereb Cortex 20:425-32. 2010
    ..The main MEG responses peaked at the primary somatosensory cortex at 54+/-2 ms. Signals and source strengths were about a fifth weaker to self-produced than external touch...
  99. pmc Reward facilitates tactile judgments and modulates hemodynamic responses in human primary somatosensory cortex
    Burkhard Pleger
    Wellcome Trust Centre for Neuroimaging, UCL, London WC1N 3AR, United Kingdom
    J Neurosci 28:8161-8. 2008
    ..imaging, we assessed whether reward can influence somatosensory judgments and modulate activity in human somatosensory cortex. Participants discriminated electrical somatosensory stimuli on an index finger with correct performance ..
  100. ncbi Cortical hyperexcitability in response to preserved spinothalamic inputs immediately after spinal cord hemisection
    J G Yague
    Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain
    Exp Neurol 227:252-63. 2011
    ..We bilaterally recorded the neural activity of the hindpaw representation of the primary somatosensory cortex evoked by stimuli delivered to the hindpaws before and immediately after a thoracic spinal cord hemisection ..
  101. ncbi Cadherin expression in the somatosensory cortex: evidence for a combinatorial molecular code at the single-cell level
    K Krishna-K
    University of Jena School of Medicine, Teichgraben 7, D 07743 Jena, Germany
    Neuroscience 175:37-48. 2011
    ..and eight δ-protocadherins (Pcdh1, Pcdh7, Pcdh8, Pcdh9, Pcdh10, Pcdh11, Pcdh17 and Pcdh19) in the primary somatosensory cortex of the adult mouse...

Research Grants72

  1. CORTICAL CONTROL OF MOVEMENT
    Asaf Keller; Fiscal Year: 2010
    ..afferents from the ventral lateral thalami nucleus (VL), and corticocortical afferents from the somatosensory cortex (SCx)...
  2. The organization and plasticity of cortical areas representing the dentition
    KENNETH CATANIA; Fiscal Year: 2009
    ..In addition, their somatosensory cortex becomes reorganized following tooth-loss...
  3. Plasticity of the Visual Cortex
    Stelios Smirnakis; Fiscal Year: 2006
    ..system that has been demonstrated by single cell recordings in numerous areas, including visual, motor, and somatosensory cortex. In the proposed project, the applicant will use high field functional magnetic resonance (fMRI) to study ..
  4. Cortical Representational Plasticity of Oral Structures
    KENNETH CATANIA; Fiscal Year: 2003
    ..The long-term goals of the proposed research are to determine how the dentition is represented in somatosensory cortex, how these representations change in response to tooth loss or disuse at different developmental stages, ..
  5. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..We assume that, just like the area of somatosensory cortex that previously processed sensory input from a now amputated hand, starts responding to touches on the face ..
  6. Fragile X and Synaptic Plasticity
    Julie C Lauterborn; Fiscal Year: 2012
    ..Aim 4C will then test if in vivo treatments with an ampakine, MPEP, or both, normalize spine measures in somatosensory cortex and hippocampal field CA1...
  7. Local Circuit Properties of Mouse Corticospinal Neurons
    Patrick L Sheets; Fiscal Year: 2011
    ..Ih has been observed in L5 neurons of somatosensory cortex, and entorhinal cortex...
  8. PDZ DOMAINS AND AMPA RECEPTOR FUNCTION
    Richard L Huganir; Fiscal Year: 2013
    ..role of PDZ domain-based receptor complexes in several forms of plasticity in the hippocampus, cerebellum, somatosensory cortex and the amygdala...
  9. NG2 cell dynamics in the normal and injured adult central nervous system
    Ethan Hughes; Fiscal Year: 2012
    ..Here, I propose to use two-photon imaging of NG2 cells in the somatosensory cortex to study the behavior of NG2 cells within the adult mouse brain...
  10. Mapping the Inputs onto Neocortical Chandelier Cells
    Jason M Tucciarone; Fiscal Year: 2013
    ..is conserved across brain regions, I will label the local and long range inputs to L2 and L5 ChCs in the somatosensory cortex to compare with the data from mPFC...
  11. Migraine pathophysiology: neural basis of photophobia
    Rami Burstein; Fiscal Year: 2013
    ..apposed by many afferents of retinal origin, and that their own axons branched extensively into the primary somatosensory cortex. Here we will focus on this unique integration of meningeal nociception and retinal photoreception by ..
  12. Mechanisms Underlying Specification of Neuronal Projection Identity in the Cortex
    Karpagam Srinivasan; Fiscal Year: 2010
    ..For example, layer 5 pyramidal neurons from the motor and somatosensory cortex send axonal projections subcerebrally down to the spinal cord (corticospinal tract or CST), while layers 2/..
  13. Role of glial glutamate transporters in V1 plasticity and development
    Jeremy C Petravicz; Fiscal Year: 2013
    ..roles that can affect the processing of sensory information, evidence for which can be found in the somatosensory cortex, olfactory bulb, and spinal cord...
  14. Sleep, proprioception, and forebrain activity in infant mutant mice
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..of times each day, and sensory feedback from twitching produces substantial stimulation to the primary somatosensory cortex. In fact, each day in neocortex, sleep- related twitches trigger thousands of cortical oscillatory events - ..
  15. Synaptic Circuitry in Stroke
    Sergei A Kirov; Fiscal Year: 2013
    ..in vivo 2-photon laser scanning microscopy of fluorescent neurons, astrocytes and blood flow in adult mouse somatosensory cortex with other sophisticated in vivo approaches such as laser speckle and intrinsic optical signal imaging ..
  16. Mechanisms Underlying Activity-Dependent Interneuron Development
    NATALIA VANESA DE MARCO GARCIA; Fiscal Year: 2013
    ..The experiments in this grant proposal will be carried out in vivo in the mouse somatosensory cortex. The principles that will emerge from these studies, however, are expected to apply to other regions of the ..
  17. ATTENTION AND TACTILE PROCESSING IN SOMATOSENSORY CORTEX
    Steven S Hsiao; Fiscal Year: 2013
    ..The first is to investigate how cutaneous and proprioceptive input related to object shape is integrated in somatosensory cortex. The second is to investigate how the size of objects are represented in cortex...
  18. Neural Mechanisms of Tactile Sensation in Rodent Somatosensory Cortex
    Daniel Feldman; Fiscal Year: 2013
    ..A powerful model system to investigate cortical function is the whisker somatosensory cortex (S1) of rodents...
  19. Controlling Interareal Gamma Coherence by Optogenetics, Pharmacology and Behavior
    Timothy J Buschman; Fiscal Year: 2012
    ..We will optogenetically induce local gamma oscillations in a source area (primary somatosensory cortex, SI) and measure their coherence with a target area (secondary somatosensory cortex, SII)...
  20. Mechanisms of Large-scale Reorganization in Rat Forepaw Barrel Subfiels Cortex
    Robert S Waters; Fiscal Year: 2010
    ..The rat forepaw barrel subfield in first somatosensory cortex, ventral posterior lateral nucleus (VPL), thalamic reticular nucleus (RTN), and cuneate nucleus (CN) will ..
  21. Functional architecture of motor cortex: Topography and connections
    DYLAN FRANCIS COOKE; Fiscal Year: 2011
    ..This contrasts with the fine somatotopy of primary somatosensory cortex. Recent studies in primates have suggested additional organizing principles that, together with large-scale ..
  22. Controlling Interareal Gamma Coherence by Optogenetics, Pharmacology and Behavior
    Timothy J Buschman; Fiscal Year: 2013
    ..We will optogenetically induce local gamma oscillations in a source area (primary somatosensory cortex, SI) and measure their coherence with a target area (secondary somatosensory cortex, SII)...
  23. Effects of developmental ethanol exposure on brain development
    Sandra M Mooney; Fiscal Year: 2013
    ..the postnatal neurogenesis in the VB may be important for matching neuronal number in the VB with that in somatosensory cortex. The goal of the present study is to understand the apparent protection this region has against the ..
  24. NOVEL MECHANISM FOR GLUTAMATE-DEPENDENT EXCITOTOXICITY
    Andrei B Belousov; Fiscal Year: 2013
    ..using oxygen-glucose deprivation as an in vitro model of ischemia, neuronal cultures prepared from the somatosensory cortex of wild-type and connexin 36 knockout mice, cell culture infections with lentiviral vectors, electrotonic ..
  25. MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURY
    Robert J Morecraft; Fiscal Year: 2013
    ..a) the primary motor cortex (M1) + the dorsolateral premotor cortex (LPMCd) and;b) M1 + LPMCd + the primary somatosensory cortex (S1)...
  26. The Neural Substrates of Social Interactions
    Rupa Gupta; Fiscal Year: 2012
    ..and experiences relies on additional structures involved in emotional processing, including right somatosensory cortex, and insula...
  27. MECHANISMS OF MOTOR RECOVERY AFTER SUBTOTAL BRAIN INJURY
    ROBERT MORECRAFT; Fiscal Year: 2009
    ..a) the primary motor cortex (M1) + the dorsolateral premotor cortex (LPMCd) and;b) M1 + LPMCd + the primary somatosensory cortex (S1)...
  28. Pathophysiogenomic markers:ethanol-induced brain damage
    Frank A Middleton; Fiscal Year: 2010
    ..positively and negatively) with RNA levels in three different brain regions (cerebellum, hippocampus, and somatosensory cortex) of the same animal...
  29. Microscopic imaging of neuro-capillary coupling in brain cortex
    Jonghwan Lee; Fiscal Year: 2013
    ..in vivo (Specific Aim 3): (H1) Capillaries regulate blood flow in response to neuronal activation in the somatosensory cortex, directly proving the capillary control of flow;(H2) Neuro-capillary coupling leads to an early capillary ..
  30. Slowly Inactivating K+ Channels in Neocortical Pyramidal Cells
    ROBERT C FOEHRING; Fiscal Year: 2013
    ..consequences of voltage-gated potassium channel (Kv) diversity in neocortical pyramidal cells from somatosensory cortex. Specifically, we will study the functions of three types of potassium channels in neocortical pyramidal ..
  31. Cortical modulation of brainstem circuits
    Asaf Keller; Fiscal Year: 2013
    ..a pivotal role in pain processing, receives cortical inputs primarily from primary (SI) and second (SII) somatosensory cortex, and the insular cortex...
  32. Low-Dose Methylphenidate and the Prefrontal Cortex
    Craig W Berridge; Fiscal Year: 2013
    ..that cognition-enhancing doses of MPH increase PFC neuronal responsivity, an effect not observed in the somatosensory cortex. Combined, these observations suggest a prominent role of the PFC in the cognition-enhancing actions of low-..
  33. METHAMPHETAMINE ABUSE AND CORTICAL CELL INJURY
    JOHN FOSTER MARSHALL; Fiscal Year: 2012
    ..In addition, this drug produces a degeneration of pyramidal and stellate cells in the rat somatosensory cortex. Moreover, the degeneration of somatosensory cortical neurons appears to represent only the most visible ..
  34. EXERCISE AND PARKINSON'S: COMPARING INTERVENTIONS AND EXPLORING NEURAL MECHANISMS
    Gammon M Earhart; Fiscal Year: 2013
    ..We expect treadmill training to enhance activity and connectivity of the primary somatosensory cortex and the cerebellum. We do not expect changes in brain activity or connectivity in the control group...
  35. Brain Plasticity in Carpal Tunnel Syndrome and its Response to Acupuncture
    Vitaly Napadow; Fiscal Year: 2012
    ..in the brain of CTS patients has been noted by several neuroimaging studies, and includes altered primary somatosensory cortex (SI) somatotopy and primary sensorimotor hyperactivation...
  36. Sensorimotor abnormalities in childhood onset psychotic disorders
    Donald C Rojas; Fiscal Year: 2013
    ..Second, we believe that a failure in feed-forward efferent copy mechanisms from motor to somatosensory cortex results in improper perceptual feedback during patient's own movements...
  37. Mechanisms and Perceptual Consequences of Somatosensory Cortical Plasticity
    NATALIE KATHERINE TRZCINSKI; Fiscal Year: 2013
    ..to simultaneous stimulation of multiple digits develop novel multi-digit representations in primary somatosensory cortex, area 3b (SI, 3b)...
  38. Testing the excitability of inhibitory neurons
    MOLLY MAUREEN HUNTSMAN; Fiscal Year: 2012
    ..We hypothesize that defects in inhibitory neurotransmission in primary somatosensory cortex underlie aspects of the hyperexcitable phenotype of FXS, including its comorbidity with epilepsy...
  39. Neurocognitive Mechanisms and Recovery from Addiction
    Yih Ing Hser; Fiscal Year: 2012
    ..for processing reward and emotional information, including the nucleus accumbens, amygdala, insular and somatosensory cortex, ventromedial prefrontal cortex, and anterior cingulate, will be quantified for each subject from high ..
  40. Fully Implantable and Programmable Spike-based Codecs for Neuroprosthetics
    Kwabena Boahen; Fiscal Year: 2013
    ..a 96-microelectrode recording array and a 9-channel optogenetic stimulator implanted in its premotor and somatosensory cortex, respectively, control a human-like robotic arm...
  41. Cortical reorganization and behavioral recovery after sensory loss
    Hui Xin Qi; Fiscal Year: 2013
    ..and to correlate the time course of behavioral recovery with fMRI activation patterns in higher-order somatosensory cortex of monkeys that had intensive training of the impaired hand and monkeys that had no training. 2...
  42. Objective Pain Measures in Awake Sedated, Anesthetized Individuals with NIRS
    David Borsook; Fiscal Year: 2013
    ..the physician to measure activity in specific brain regions involved in the sensation of pain (primary somatosensory cortex, SI) or motor planning/escape (supplementary motor cortex, SMA)...
  43. Femtosecond laser-produced sub-surface cuts to halt focal epileptic seizures
    Theodore H Schwartz; Fiscal Year: 2013
    ..side effects of the most promising laser cuts from Aim 1 by recording changes in evoked signals in somatosensory cortex after whisker stimulation...
  44. ETHANOL EFFECT ON THE BASAL FOREBRAIN CORTEX SYSTEM
    Michael Miller; Fiscal Year: 1999
    ..1) The effect of ethanol on the number of neurons in the basal forebrain and in the barrels of somatosensory cortex (segments which receive input from the mystacial vibrissae) will be determined using rigorous morphometric ..
  45. Functions of naturally diverse inhibitory networks in neocortex
    Shane R Crandall; Fiscal Year: 2013
    ..All my data will be compared to data I obtain from the primary somatosensory cortex (SI), a leading model for studying the structure and physiology of neocortical circuits...
  46. High-speed, wide field fluorescent imaging of cortex in freely moving animals
    Vincent A Pieribone; Fiscal Year: 2013
    ..Finally, the instruments will be tested in imaging studies of the rat somatosensory cortex (barrel cortex). Cortical responses to object discrimination will be studied in freely moving rats...
  47. High-speed, wide field fluorescent imaging of cortex in freely moving animals
    VINCENT A contact PIERIBONE; Fiscal Year: 2011
    ..iii) Finally the instrument will be tested in imaging studies of the rat somatosensory cortex (barrel cortex). Transcortical responses to object discrimination will be studied in freely moving rats...
  48. Regulation of Anatomical Plasticity and Perceptual Learning by NgR1
    Aaron W McGee; Fiscal Year: 2012
    ..The barrel field in somatosensory cortex (barrel cortex) has been a favored system for examining spine remodeling during sensory experience due to ..
  49. Multichannel Microstimulation of Primary Afferent Neurons to Restore Propriocepti
    Michael L Boninger; Fiscal Year: 2013
    ..the nature of sensory feedback and the way in which peripheral sensory activity is conveyed to primary somatosensory cortex (S1), and to develop a somatosensory neural interface (SSNI) that will provide the user with proprioceptive ..
  50. Forebrain-Cerebellar Interaction During Learning
    John F Disterhoft; Fiscal Year: 2012
    ..2. Barrel columns in somatosensory cortex will be studied to determine how neurons in different layers of this sensory neocortex change during ..
  51. Inhibitory mechanisms for sensory map plasticity in cerebral cortex.
    Daniel Feldman; Fiscal Year: 2013
    ..This is studied in the somatosensory cortex of rodents, which is a canonical model system for cortical function...
  52. Motor Skill Learning in Autism
    Stewart H Mostofsky; Fiscal Year: 2012
    ..an over-expression of short-range axons, including those connecting neighboring primary motor cortex and somatosensory cortex, where proprioception is encoded...
  53. Cross-modal interactions between vision and touch
    KRISHNANKUTTY SATHIAN; Fiscal Year: 2013
    ..g. "He had a rough day") recruits texture-selective somatosensory cortex while listening to sentencing containing shape metaphors recruits shape-selective visual cortex, by ..
  54. Neurotransmitter Actions in the Neocortex and Thalamus
    David A McCormick; Fiscal Year: 2013
    ..investigations in vivo by studying the activity of identified subpopulations of interneurons in the mouse somatosensory cortex through patch clamp recording in a custom-built two-photon microscope...
  55. Influence of motor cortex on network activity and sensory processing in S1
    EDWARD W ZAGHA; Fiscal Year: 2013
    ..we are able to control the activity of neurons in motor cortex and measure cellular and network activity in somatosensory cortex. We have gathered exciting preliminary data that stimulating motor cortex can effectively alter the ongoing ..
  56. Neocortical Precursor Transplant for Circuitry Repair
    Jeffrey D Macklis; Fiscal Year: 2010
    ..Our four specific aims will investigate whether new neurons in adult vibrissal somatosensory cortex Aim 1) acquire the precise phenotype of endogenous neurons in their cellular and temporal patterns of ..
  57. SOMATOSENSORY CORTICAL DEVELOPMENT AND PLASTICITY
    Reha S Erzurumlu; Fiscal Year: 2013
    ..molecular genetic and neuroanatomical approaches will be used to elucidate structural changes in the somatosensory cortex and thalamus of these mice...
  58. Can therapy alter CNS processing of chronic pain: A longitudinal study
    MAGDALENA R NAYLOR; Fiscal Year: 2013
    ..results reveal that after group CBT chronic pain patients show reduced insula (IC), amygdala and primary somatosensory cortex (S1) reactivity to arousing stimuli, and increased activation in the prefrontal cortex and anterior ..
  59. Behavioral state development in infants
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..identify in newborn rats the neural circuitry that transmits spontaneous and evoked sensory information to somatosensory cortex. This aim will be accomplished using a combination of methods, including surface EEG, amperometry, and ..
  60. Pain Suppression via Area 3a Lesion
    Barry L Whitsel; Fiscal Year: 2013
    ..well as reports of surgical ablations in human chronic pain patients, suggest that some part of the primary somatosensory cortex (SI) is critically involved in pain generation...
  61. Cortical Processing of Tactual Spacial Information
    Steven S Hsiao; Fiscal Year: 2012
    ..of this application are to understand how two-dimensional shape, texture and motion are represented in somatosensory cortex. Shape, texture and motion are important in all sensory systems...
  62. Synaptic basis for map plasticity in cerebral cortex
    Daniel E Feldman; Fiscal Year: 2010
    ..We propose to elucidate these mechanisms in the whisker region of rodent somatosensory cortex. We will also test whether, as these findings suggest, CB receptors play an unexpected causal role in ..
  63. Role of oculomotor proprioception in spatial processing by the parietal cortex
    LINUS DASHIH SUN; Fiscal Year: 2013
    ..Wang et al (2007) discovered an eye position signal in the primary somatosensory cortex (area 3a). Preliminary results show that reversible cooling of area 3a eliminates gain fields...
  64. Anatomical Origins of Somatosensory Cortical Magnification in the Star-nosed Mole
    EVA SAWYER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): In our somatosensory cortex our fingertips have representations that are disproportionally large compared to the skin surface area that is not clearly explained by innervation patterns[1, 2]...
  65. Neural Correlate of Perfusion Based fMRI
    Seong Kim; Fiscal Year: 2012
    ..The highest CBF and CBV responses occur within layer 4 in the somatosensory cortex and visual cortex, and within orientation-selective columns in the visual cortex...
  66. DEFINITION AND DEVELOPMENT OF THE PHENOTYPE IN AUTISM
    Sally Rogers; Fiscal Year: 2001
    ..We will specifically: 1) Using MEG and EEG, we will quantify reactivity of primary auditory and somatosensory cortex to stimuli of varying intensity; 2) By localizing and quantifying very high frequency (VHF) MEG activity (..
  67. REFLEX REGULATION OF THE HUMAN BREATHING PATTERN
    JOHN DAUBENSPECK; Fiscal Year: 1999
    ..These respiratory-related evoked potentials (RREPs) are distributed over the somatosensory cortex with location and timing dependent upon the specific site of sensation...
  68. Effects of Lead on Cortical Development and Plasticity
    MARY A WILSON; Fiscal Year: 2010
    ..The barrel field of rodent somatosensory cortex contains a map of the whisker pad in which discrete clusters of neurons, called barrels, receive input from ..
  69. BEHAVIORAL CORRELATES OF NEURAL PLASTICITY
    V Ramachandran; Fiscal Year: 2001
    ..The somatosensory cortex of adult primates is capable of a surprising degree of functional reorganization...
  70. Imaging neural networks in mouse somatosensory cortex
    JOSHUA BRUMBERG; Fiscal Year: 2003
    ..retrogradely transported back to independent networks of pyramidal cells located in layer VI of the primary somatosensory cortex, following injections into the ipsilateral motor cortex and/or the ventral posterior nucleus of the ..
  71. Spatial-temporal stimulus interactions in primate SI hand cortex neurons
    Jamie Reed; Fiscal Year: 2009
    ..requires integration of information from across the hand, and this integration is likely to involve primary somatosensory cortex (area 3b)...
  72. Experience-Dependent Enhancement of Neuronal Integration
    ARTHUR CZUPRYN; Fiscal Year: 2006
    ..neurons will be modulated by sensory experience, which produces activity-dependent plastic changes in the somatosensory cortex of adult mice. The group of Prof...