visual cortex

Summary

Summary: Area of the occipital lobe concerned with vision.

Top Publications

  1. pmc Population receptive field estimates in human visual cortex
    Serge O Dumoulin
    Psychology, Stanford University, Stanford, CA 94305, USA
    Neuroimage 39:647-60. 2008
  2. pmc Membrane potential synchrony in primary visual cortex during sensory stimulation
    Jianing Yu
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 68:1187-201. 2010
  3. pmc Differences in gamma frequencies across visual cortex restrict their possible use in computation
    Supratim Ray
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:885-96. 2010
  4. pmc Decoding reveals the contents of visual working memory in early visual areas
    Stephenie A Harrison
    Psychology Department and Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee 37240, USA
    Nature 458:632-5. 2009
  5. pmc Local origin of field potentials in visual cortex
    Steffen Katzner
    Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
    Neuron 61:35-41. 2009
  6. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
  7. pmc Network anatomy and in vivo physiology of visual cortical neurons
    Davi D Bock
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:177-82. 2011
  8. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
  9. ncbi Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects
    R P Rao
    Salk Institute, Sloan Center for Theoretical Neurobiology, La Jolla, California, USA
    Nat Neurosci 2:79-87. 1999
  10. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996

Research Grants

Detail Information

Publications314 found, 100 shown here

  1. pmc Population receptive field estimates in human visual cortex
    Serge O Dumoulin
    Psychology, Stanford University, Stanford, CA 94305, USA
    Neuroimage 39:647-60. 2008
    ..We report quantitative estimates of pRF size in medial, lateral and ventral occipital regions of human visual cortex. Also, we quantify the amount of input from ipsi- and contralateral visual fields...
  2. pmc Membrane potential synchrony in primary visual cortex during sensory stimulation
    Jianing Yu
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Neuron 68:1187-201. 2010
    When the primary visual cortex (V1) is activated by sensory stimulation, what is the temporal correlation between the synaptic inputs to nearby neurons? This question underlies the origin of correlated activity, the mechanism of how ..
  3. pmc Differences in gamma frequencies across visual cortex restrict their possible use in computation
    Supratim Ray
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:885-96. 2010
    ..Instead, our results suggest that the gamma rhythm arises from local interactions between excitation and inhibition...
  4. pmc Decoding reveals the contents of visual working memory in early visual areas
    Stephenie A Harrison
    Psychology Department and Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee 37240, USA
    Nature 458:632-5. 2009
    ..Here we show that orientations held in working memory can be decoded from activity patterns in the human visual cortex, even when overall levels of activity are low...
  5. pmc Local origin of field potentials in visual cortex
    Steffen Katzner
    Smith Kettlewell Eye Research Institute, San Francisco, CA 94115, USA
    Neuron 61:35-41. 2009
    ..We determined the orientation selectivity of stimulus-evoked LFP signals in primary visual cortex and were able to predict it on the basis of the surrounding map of orientation preference...
  6. ncbi Neurophysiological investigation of the basis of the fMRI signal
    N K Logothetis
    Max Planck Institute for Biological Cybernetics, Tuebingen, Germany
    Nature 412:150-7. 2001
    ..activity with highly spatio-temporally resolved blood-oxygen-level-dependent (BOLD) fMRI responses from the visual cortex of monkeys...
  7. pmc Network anatomy and in vivo physiology of visual cortical neurons
    Davi D Bock
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 471:177-82. 2011
    ..a functional property--the preferred stimulus orientation--of a group of neurons in the mouse primary visual cortex. Large-scale electron microscopy of serial thin sections was then used to trace a portion of these neurons' ..
  8. pmc Highly nonrandom features of synaptic connectivity in local cortical circuits
    Sen Song
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA
    PLoS Biol 3:e68. 2005
    ..with several hundred simultaneous quadruple whole-cell recordings from layer 5 pyramidal neurons in the rat visual cortex. Analysis of this dataset revealed several nonrandom features in synaptic connectivity...
  9. ncbi Predictive coding in the visual cortex: a functional interpretation of some extra-classical receptive-field effects
    R P Rao
    Salk Institute, Sloan Center for Theoretical Neurobiology, La Jolla, California, USA
    Nat Neurosci 2:79-87. 1999
    ..results suggest that rather than being exclusively feedforward phenomena, nonclassical surround effects in the visual cortex may also result from cortico-cortical feedback as a consequence of the visual system using an efficient ..
  10. ncbi Synaptic activity and the construction of cortical circuits
    L C Katz
    Howard Hughes Medical Institute and the Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Science 274:1133-8. 1996
    ..The sequential combination of spontaneously generated and experience-dependent neural activity endows the brain with an ongoing ability to accommodate to dynamically changing inputs during development and throughout life...
  11. ncbi Alpha-band electroencephalographic activity over occipital cortex indexes visuospatial attention bias and predicts visual target detection
    Gregor Thut
    Center for Noninvasive Brain Stimulation, Harvard Medical School, and Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Neurosci 26:9494-502. 2006
    ..They suggest that the momentary direction of attention, predicting spatial biases in imminent visual processing, can be estimated from a lateralization index of posterior alpha-activity...
  12. pmc Functional specificity of local synaptic connections in neocortical networks
    Ho Ko
    Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Nature 473:87-91. 2011
    ..layer 2/3 pyramidal neurons in vitro, the response properties of which were first characterized in mouse visual cortex in vivo...
  13. ncbi Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex
    Kenichi Ohki
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 433:597-603. 2005
    ..Here, we labelled thousands of neurons of the visual cortex with a calcium-sensitive indicator in vivo...
  14. pmc Highly selective receptive fields in mouse visual cortex
    Cristopher M Niell
    Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, California 94143 0444, USA
    J Neurosci 28:7520-36. 2008
    Genetic methods available in mice are likely to be powerful tools in dissecting cortical circuits. However, the visual cortex, in which sensory coding has been most thoroughly studied in other species, has essentially been neglected in ..
  15. ncbi Decorrelated neuronal firing in cortical microcircuits
    Alexander S Ecker
    Max Planck Institute for Biological Cybernetics, 72076 Tubingen, Germany
    Science 327:584-7. 2010
    ..multitetrode arrays offering unprecedented recording quality to reexamine this question in the primary visual cortex of awake macaques...
  16. ncbi Computational modelling of visual attention
    L Itti
    Hedco Neuroscience Building, University of Southern California, 3641 Watt Way, Los Angeles, California 90089 2520, USA
    Nat Rev Neurosci 2:194-203. 2001
    ..Insights from these five key areas provide a framework for a computational and neurobiological understanding of visual attention...
  17. ncbi Emergence of simple-cell receptive field properties by learning a sparse code for natural images
    B A Olshausen
    Department of Psychology, Cornell University, Ithaca, New York 14853, USA
    Nature 381:607-9. 1996
    The receptive fields of simple cells in mammalian primary visual cortex can be characterized as being spatially localized, oriented and bandpass (selective to structure at different spatial scales), comparable to the basis functions of ..
  18. pmc Different origins of gamma rhythm and high-gamma activity in macaque visual cortex
    Supratim Ray
    Department of Neurobiology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Biol 9:e1000610. 2011
    ..We studied the relationship between high-gamma power, gamma rhythm, and spiking activity in the primary visual cortex (V1) of awake monkeys while varying the stimulus size, which increased the gamma power but decreased the ..
  19. ncbi Entrainment of neuronal oscillations as a mechanism of attentional selection
    Peter Lakatos
    Cognitive Neuroscience and Schizophrenia Program, Nathan Kline Institute, Orangeburg, NY 10962, USA
    Science 320:110-3. 2008
    ..Here, we show that when attended stimuli are in a rhythmic stream, delta-band oscillations in the primary visual cortex entrain to the rhythm of the stream, resulting in increased response gain for task-relevant events and ..
  20. pmc Normalization as a canonical neural computation
    Matteo Carandini
    UCL Institute of Ophtalmology, University College London, 11 43 Bath Street, London EC1V 9EL, UK ac uk
    Nat Rev Neurosci 13:51-62. 2012
    ..Normalization was developed to explain responses in the primary visual cortex and is now thought to operate throughout the visual system, and in many other sensory modalities and brain ..
  21. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
    ..The map of the whole cortical circuit shows that there are very few "strong" but many "weak" excitatory projections, each of which may involve only a few percentage of the total complement of excitatory synapses of a single neuron...
  22. pmc Parvalbumin-expressing interneurons linearly transform cortical responses to visual stimuli
    Bassam V Atallah
    Computational Neurosciences Graduate Program, University of California San Diego, La Jolla, California 92093 0634, USA
    Neuron 73:159-70. 2012
    ..By bidirectionally manipulating PV cell activity in visual cortex we show that these neurons strongly modulate layer 2/3 pyramidal cell spiking responses to visual stimuli ..
  23. pmc Division and subtraction by distinct cortical inhibitory networks in vivo
    Nathan R Wilson
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 488:343-8. 2012
    ..Here we use a new platform for two-way light-based circuit interrogation in visual cortex in vivo to show the computational implications of modulating different subclasses of inhibitory neurons during ..
  24. ncbi Dendritic organization of sensory input to cortical neurons in vivo
    Hongbo Jia
    Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
    Nature 464:1307-12. 2010
    In sensory cortex regions, neurons are tuned to specific stimulus features. For example, in the visual cortex, many neurons fire predominantly in response to moving objects of a preferred orientation...
  25. pmc Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells
    Bao Hua Liu
    Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA 90033, USA
    Neuron 71:542-54. 2011
    Orientation selectivity (OS) is an emergent property in the primary visual cortex (V1). How OS arises from synaptic circuits remains unsolved...
  26. ncbi Activity-dependent scaling of quantal amplitude in neocortical neurons
    G G Turrigiano
    Department of Biology and Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA
    Nature 391:892-6. 1998
    ....
  27. pmc miR-132, an experience-dependent microRNA, is essential for visual cortex plasticity
    Nikolaos Mellios
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 14:1240-2. 2011
    Using quantitative analyses, we identified microRNAs (miRNAs) that were abundantly expressed in visual cortex and that responded to dark rearing and/or monocular deprivation...
  28. ncbi Dynamic predictions: oscillations and synchrony in top-down processing
    A K Engel
    Cellular Neurobiology Group, Institute for Medicine, Research Centre Julich, 52425 Julich, Germany
    Nat Rev Neurosci 2:704-16. 2001
    ....
  29. pmc High-frequency, long-range coupling between prefrontal and visual cortex during attention
    Georgia G Gregoriou
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 324:1207-10. 2009
    ..Does this synchrony result from intrinsic activity in visual cortex or from inputs from other structures? Using paired recordings in the frontal eye field (FEF) and area V4, we ..
  30. ncbi Reducing intracortical inhibition in the adult visual cortex promotes ocular dominance plasticity
    Alexey Harauzov
    Scuola Normale Superiore, 56126 Pisa, Italy
    J Neurosci 30:361-71. 2010
    ..is suggested to be crucial for the closure of the critical period for ocular dominance (OD) plasticity in the visual cortex. We find that reduction of GABAergic transmission in the adult rat visual cortex partially reactivates OD ..
  31. ncbi The antidepressant fluoxetine restores plasticity in the adult visual cortex
    José Fernando Maya Vetencourt
    Scuola Normale Superiore, Piazza dei Cavalieri, I 56100 Pisa, Italy
    Science 320:385-8. 2008
    ..by reduced intracortical inhibition and increased expression of brain-derived neurotrophic factor in the visual cortex. Cortical administration of diazepam prevented the effects induced by fluoxetine, indicating that the ..
  32. pmc Attention improves performance primarily by reducing interneuronal correlations
    Marlene R Cohen
    Howard Hughes Medical Institute and Harvard Medical School Department of Neurobiology, Boston, Massachusetts, USA
    Nat Neurosci 12:1594-600. 2009
    ..These results suggest that the representation of sensory information in populations of neurons and the way attention affects the sensitivity of the population may only be understood by considering the interactions between neurons...
  33. pmc A neural circuit for spatial summation in visual cortex
    Hillel Adesnik
    Howard Hughes Medical Institute, Center for Neural Circuits and Behavior, Neurobiology Section and Department of Neuroscience, University of California San Diego, La Jolla, California 92093 0634, USA
    Nature 490:226-31. 2012
    The response of cortical neurons to a sensory stimulus is modulated by the context. In the visual cortex, for example, stimulation of a pyramidal cell's receptive-field surround can attenuate the cell's response to a stimulus in the ..
  34. ncbi View from the top: hierarchies and reverse hierarchies in the visual system
    Shaul Hochstein
    Department of Neurobiology, Neural Computation Center, Hebrew University, Jerusalem, Israel
    Neuron 36:791-804. 2002
    ..Search for conjunctions or fine discriminations depends on reentry to low-level specific receptive fields using serial focused attention, consistent with recently reported primary visual cortex effects.
  35. pmc The normalization model of attention
    John H Reynolds
    Salk Institute for Biological Studies, La Jolla, CA 92037 1099, USA
    Neuron 61:168-85. 2009
    Attention has been found to have a wide variety of effects on the responses of neurons in visual cortex. We describe a model of attention that exhibits each of these different forms of attentional modulation, depending on the stimulus ..
  36. ncbi Sparse coding of sensory inputs
    Bruno A Olshausen
    Center for Neuroscience, UC Davis, 1544 Newton Court, Davis, California 95616, USA
    Curr Opin Neurobiol 14:481-7. 2004
    ..Recent physiological recordings from sensory neurons have indicated that sparse coding could be a ubiquitous strategy employed in several different modalities across different organisms...
  37. ncbi Natural image statistics and neural representation
    E P Simoncelli
    Howard Hughes Medical Institute, Center for Neural Science, and Courant Institute of Mathematical Sciences, New York University, New York, NY 10003 USA
    Annu Rev Neurosci 24:1193-216. 2001
    ....
  38. ncbi Differential connectivity and response dynamics of excitatory and inhibitory neurons in visual cortex
    Sonja B Hofer
    Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK
    Nat Neurosci 14:1045-52. 2011
    ..and network activity in pyramidal cells and fast-spiking parvalbumin-expressing (PV) interneurons in mouse visual cortex. In pyramidal cell populations, patterns of neuronal correlations were largely stimulus-dependent, indicating ..
  39. pmc Decoding the visual and subjective contents of the human brain
    Yukiyasu Kamitani
    ATR Computational Neuroscience Laboratories, 2 2 2 Hikaridai, Keihanna Science City, Kyoto 619 0288, Japan
    Nat Neurosci 8:679-85. 2005
    ..These results demonstrate that fMRI activity patterns in early visual areas, including primary visual cortex (V1), contain detailed orientation information that can reliably predict subjective perception...
  40. ncbi Increased activity in human visual cortex during directed attention in the absence of visual stimulation
    S Kastner
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuron 22:751-61. 1999
    When subjects direct attention to a particular location in a visual scene, responses in the visual cortex to stimuli presented at that location are enhanced, and the suppressive influences of nearby distractors are reduced...
  41. ncbi Very slow activity fluctuations in monkey visual cortex: implications for functional brain imaging
    David A Leopold
    Max Planck Institut für biologische Kybernetik, Spemannstrasse 38, 72076 Tubingen, Germany
    Cereb Cortex 13:422-33. 2003
    ..in band-limited power (BLP) of local field potential (LFP) signals recorded from multiple electrodes in visual cortex of the monkey during different behavioral states...
  42. ncbi Reactivation of ocular dominance plasticity in the adult visual cortex
    Tommaso Pizzorusso
    Scuola Normale Superiore, 56100 Pisa, Italy
    Science 298:1248-51. 2002
    ..whether the developmental maturation of the ECM is inhibitory for experience-dependent plasticity in the visual cortex. The organization of CSPGs into perineuronal nets coincided with the end of the critical period and was ..
  43. ncbi The phase of ongoing EEG oscillations predicts visual perception
    Niko A Busch
    Universite de Toulouse, Centre de Recherche Cerveau et Cognition, Universite Paul Sabatier, France
    J Neurosci 29:7869-76. 2009
    ..The results support the notion that ongoing oscillations shape our perception, possibly by providing a temporal reference frame for neural codes that rely on precise spike timing...
  44. ncbi Visual field maps in human cortex
    Brian A Wandell
    Psychology Department, Stanford University, Stanford, CA 94305 2130, USA
    Neuron 56:366-83. 2007
    Much of the visual cortex is organized into visual field maps: nearby neurons have receptive fields at nearby locations in the image...
  45. ncbi Ventral visual cortex in humans: cytoarchitectonic mapping of two extrastriate areas
    Claudia Rottschy
    Institute of Medicine, Research Centre Julich, Germany
    Hum Brain Mapp 28:1045-59. 2007
    The extrastriate visual cortex forms a complex system enabling the analysis of visually presented objects...
  46. ncbi The emergence of functional microcircuits in visual cortex
    Ho Ko
    Department of Neuroscience, Physiology and Pharmacology, University College London, 21 University Street, London WC1E 6DE, UK
    Nature 496:96-100. 2013
    ..synaptic connectivity to visual response properties of neighbouring layer 2/3 pyramidal neurons in mouse visual cortex at different postnatal ages, using two-photon calcium imaging in vivo and multiple whole-cell recordings in ..
  47. ncbi Integrated model of visual processing
    J Bullier
    Centre de Recherche Cerveau et Cognition CNRS UPS, Universite Paul Sabatier, 133 route de Narbonne, 31062, Cedex 4, Toulouse, France
    Brain Res Brain Res Rev 36:96-107. 2001
    ....
  48. pmc Lynx1, a cholinergic brake, limits plasticity in adult visual cortex
    Hirofumi Morishita
    FM Kirby Neurobiology Center, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Science 330:1238-40. 2010
    ..we identified an increase in expression of Lynx1 protein in mice that prevented plasticity in the primary visual cortex late in life. Removal of this molecular brake enhanced nicotinic acetylcholine receptor signaling...
  49. pmc Spatial and temporal scales of neuronal correlation in primary visual cortex
    Matthew A Smith
    Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 28:12591-603. 2008
    ..These properties and the circuit mechanism they imply provide new constraints on the functional role that correlation may play in visual processing...
  50. pmc Matching categorical object representations in inferior temporal cortex of man and monkey
    Nikolaus Kriegeskorte
    Section on Functional Imaging Methods, Laboratory of Brain and Cognition, National Institute of Mental Health, NIH, Bethesda, MD 20892 1148, USA
    Neuron 60:1126-41. 2008
    ..Our findings suggest that primate IT across species may host a common code, which combines a categorical and a continuous representation of objects...
  51. pmc Local GABA circuit control of experience-dependent plasticity in developing visual cortex
    T K Hensch
    Laboratory for Neuronal Circuit Development, Brain Science Institute RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Science 282:1504-8. 1998
    ..An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model...
  52. pmc Melanopsin-expressing retinal ganglion-cell photoreceptors: cellular diversity and role in pattern vision
    Jennifer L Ecker
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    Neuron 67:49-60. 2010
    ..Thus, nonclassical retinal photoreception occurs within diverse cell types and influences circuits and functions encompassing luminance as well as spatial information...
  53. pmc GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression
    Jong H Yoon
    Department of Psychiatry and Imaging Research Center, University of California, Davis, Davis, California 95817, USA
    J Neurosci 30:3777-81. 2010
    ..10). These results suggest that a neocortical GABA deficit in subjects with schizophrenia leads to impaired cortical inhibition and that GABAergic synaptic transmission in visual cortex plays a critical role in OSSS.
  54. pmc Spatial attention decorrelates intrinsic activity fluctuations in macaque area V4
    Jude F Mitchell
    Systems Neurobiology Lab, The Salk Institute, La Jolla, CA 92037 1099, USA
    Neuron 63:879-88. 2009
    ..This attention-dependent reduction of ongoing cortical activity improves the signal-to-noise ratio of pooled neural signals substantially more than attention-dependent increases in firing rate...
  55. ncbi Structure and function of visual area MT
    Richard T Born
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115 5701, USA
    Annu Rev Neurosci 28:157-89. 2005
    ..Here we attempt a synthetic overview of the rich literature on MT with the goal of answering the question, What does MT do?..
  56. pmc Modulation of visual responses by behavioral state in mouse visual cortex
    Cristopher M Niell
    W M Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143 0444, USA
    Neuron 65:472-9. 2010
    ..We have now studied the response properties of neurons in primary visual cortex of awake mice that were allowed to run on a freely rotating spherical treadmill with their heads fixed...
  57. pmc Synaptic and network mechanisms of sparse and reliable visual cortical activity during nonclassical receptive field stimulation
    Bilal Haider
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Neuron 65:107-21. 2010
    ..spiking and membrane potential responses in classical regular spiking (RS(C)) pyramidal neurons of cat primary visual cortex. Conversely, fast-spiking interneurons exhibit increased activity and decreased selectivity during CRF + nCRF ..
  58. pmc Basal forebrain activation enhances cortical coding of natural scenes
    Michael Goard
    Howard Hughes Medical Institute, Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA
    Nat Neurosci 12:1444-9. 2009
    ..Using polytrode recording in rat visual cortex, we found that nucleus basalis stimulation caused prominent decorrelation between neurons and marked ..
  59. ncbi Electrophysiological correlates of rapid spatial orienting towards fearful faces
    Gilles Pourtois
    Neurology and Imaging of Cognition, University of Geneva, Switzerland
    Cereb Cortex 14:619-33. 2004
    ..These data suggest that activity in primary visual cortex might be enhanced by fear cues as early as 90 ms post-stimulus, and that such effects might result in a ..
  60. ncbi Mechanisms of visual attention in the human cortex
    S Kastner
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 23:315-41. 2000
    ..The competition among multiple objects in visual cortex can be biased by both bottom-up sensory-driven mechanisms and top-down influences, such as selective attention...
  61. ncbi Modulation of oscillatory neuronal synchronization by selective visual attention
    P Fries
    Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Building 49, Room 1B80, 9000 Rockville Pike, Bethesda, MD 20892 4415, USA
    Science 291:1560-3. 2001
    ..Because postsynaptic integration times are short, these localized changes in synchronization may serve to amplify behaviorally relevant signals in the cortex...
  62. ncbi BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex
    Z J Huang
    Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 98:739-55. 1999
    Maturation of the visual cortex is influenced by visual experience during an early postnatal period. The factors that regulate such a critical period remain unclear...
  63. ncbi A cortical area selective for visual processing of the human body
    P E Downing
    School of Psychology, Centre for Cognitive Neuroscience, University of Wales, Bangor LL57 2AS, UK
    Science 293:2470-3. 2001
    Despite extensive evidence for regions of human visual cortex that respond selectively to faces, few studies have considered the cortical representation of the appearance of the rest of the human body...
  64. pmc Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex
    Aaron M Kerlin
    Department of Neurobiology, Harvard Medical School, Goldenson 243, 220 Longwood Avenue, Boston, MA 02115, USA
    Neuron 67:858-71. 2010
    ..neurons (immunoreactive for parvalbumin, somatostatin, or vasoactive intestinal peptide) in layer 2/3 of mouse visual cortex. Excitatory neurons had sharp response selectivity for stimulus orientation and spatial frequency, while all ..
  65. ncbi Do we know what the early visual system does?
    Matteo Carandini
    Smith Kettlewell Eye Research Institute, San Francisco, California 94115, USA
    J Neurosci 25:10577-97. 2005
    ..They would be an invaluable guide for understanding the underlying biophysical and anatomical mechanisms and relating neural responses to visual perception...
  66. ncbi Loss of sensory input causes rapid structural changes of inhibitory neurons in adult mouse visual cortex
    Tara Keck
    Max Planck Institute of Neurobiology, Am Klopferspitz 18, D 82152 Martinsried, Germany
    Neuron 71:869-82. 2011
    ..Here, we use two-photon imaging to monitor the fine structure of inhibitory neurons in mouse visual cortex after deprivation induced by retinal lesions...
  67. ncbi Cortical sources of the early components of the visual evoked potential
    Francesco Di Russo
    Department of Neurosciences, UCSD, La Jolla, California 92093 0608, USA
    Hum Brain Mapp 15:95-111. 2002
    ..These findings clarify the anatomical origin of these VEP components, which have been studied extensively in relation to visual-perceptual processes...
  68. ncbi Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period
    Bidisha Chattopadhyaya
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Neurosci 24:9598-611. 2004
    ..In the primary visual cortex, for example, it is unknown whether, and to what extent, the formation and maturation of perisomatic synapses ..
  69. pmc Gain modulation by nicotine in macaque v1
    Anita A Disney
    Center for Neural Science, New York University, 4 Washington Place, New York, NY 10003, USA
    Neuron 56:701-13. 2007
    ..We demonstrate that at the site of thalamic input to visual cortex, the effect of this nAChR-mediated gain is an enhancement of the detection of visual stimuli.
  70. pmc Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortex
    Hesheng Liu
    Department of Neuroscience and Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    Neuron 62:281-90. 2009
    ..The timing of neurophysiological responses in visual cortex plays a key role in distinguishing between bottom-up and top-down theories...
  71. ncbi Gamma-band synchronization in visual cortex predicts speed of change detection
    Thilo Womelsdorf
    FC Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands
    Nature 439:733-6. 2006
    ....
  72. ncbi Synfire chains and cortical songs: temporal modules of cortical activity
    Yuji Ikegaya
    Department of Biological Sciences, Columbia University, New York, NY 10027, USA
    Science 304:559-64. 2004
    ..Sequences of active neurons have distinct spatial structures and are repeated in the same order over tens of seconds, revealing modular temporal dynamics. Higher order sequences are replayed with compressed timing...
  73. ncbi Excitatory cortical neurons form fine-scale functional networks
    Yumiko Yoshimura
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nature 433:868-73. 2005
    ..We tested for fine-scale specificity of connections to cortical layer 2/3 pyramidal neurons in rat visual cortex by using cross-correlation analyses of synaptic currents evoked by photostimulation...
  74. ncbi Stimulus dependence of neuronal correlation in primary visual cortex of the macaque
    Adam Kohn
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 25:3661-73. 2005
    ..We investigated the source of correlated responsivity by recording from pairs of single neurons in primary visual cortex of anesthetized macaque monkeys and comparing correlated variability and synchrony for spontaneous activity ..
  75. ncbi Robust object recognition with cortex-like mechanisms
    Thomas Serre
    Massachusetts Institute of Technology, Center for Biological and Computational Learning, McGovern Institute for Brain Research and Brain and Cognitive Sciences Department, MA 02139, USA
    IEEE Trans Pattern Anal Mach Intell 29:411-26. 2007
    ..which is motivated by biology: We describe a hierarchical system that closely follows the organization of visual cortex and builds an increasingly complex and invariant feature representation by alternating between a template ..
  76. pmc Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans
    Suresh D Muthukumaraswamy
    Cardiff University Brain Research Imaging Centre, School of Psychology and CUBRIC and Schools of Chemistry and Biosciences, Cardiff University, Cardiff, United Kingdom
    Proc Natl Acad Sci U S A 106:8356-61. 2009
    ..cortical inhibition by combining magnetic resonance spectroscopy to quantify resting GABA concentration in the visual cortex, MEG to measure stimulus-induced visual gamma oscillations and fMRI to measure the BOLD response to a simple ..
  77. pmc Development and plasticity of the primary visual cortex
    J Sebastian Espinosa
    Center for Integrative Neuroscience, Department of Physiology, 675 Nelson Rising Lane, University of California, San Francisco, San Francisco, CA 94143 0444, USA
    Neuron 75:230-49. 2012
    Hubel and Wiesel began the modern study of development and plasticity of primary visual cortex (V1), discovering response properties of cortical neurons that distinguished them from their inputs and that were arranged in a functional ..
  78. ncbi Human EEG responses to 1-100 Hz flicker: resonance phenomena in visual cortex and their potential correlation to cognitive phenomena
    C S Herrmann
    Max-Planck Institute of Cognitive Neuroscience, Postfach 500 355, 04303 Leipzig, Germany
    Exp Brain Res 137:346-53. 2001
    The individual properties of visual objects, like form or color, are represented in different areas in our visual cortex. In order to perceive one coherent object, its features have to be bound together...
  79. ncbi Tuned responses of astrocytes and their influence on hemodynamic signals in the visual cortex
    James Schummers
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 320:1638-43. 2008
    ..We used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive ..
  80. ncbi The retinotopic organization of the human middle temporal area MT/V5 and its cortical neighbors
    Hauke Kolster
    Laboratorium voor Neurofysiologie en Psychofysiologie, Katholieke Universiteit Leuven Medical School, Campus Gasthuisberg, 3000 Leuven, Belgium
    J Neurosci 30:9801-20. 2010
    ..Together with similarities in retinotopic organization and topological neighborhood, the functional properties suggest that MT/V5 in human and macaque cortex are homologous...
  81. pmc GABAA inhibition controls response gain in visual cortex
    Steffen Katzner
    UCL Institute of Ophthalmology, University College London, London EC1V 9EL, United Kingdom
    J Neurosci 31:5931-41. 2011
    ..To test these proposals, we recorded in cat primary visual cortex (V1) after local iontophoresis of gabazine, the selective GABA(A) antagonist...
  82. ncbi Reward timing in the primary visual cortex
    Marshall G Shuler
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 311:1606-9. 2006
    ..visual stimuli and subsequent rewards, the responses of a substantial fraction of neurons in the primary visual cortex evolve from those that relate solely to the physical attributes of the stimuli to those that accurately ..
  83. ncbi Spontaneously emerging cortical representations of visual attributes
    Tal Kenet
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    Nature 425:954-6. 2003
    ..Using voltage sensitive dye imaging, we previously established a close link between ongoing activity in the visual cortex of anaesthetized cats and the spontaneous firing of a single neuron...
  84. ncbi Functional magnetic resonance imaging (fMRI) "brain reading": detecting and classifying distributed patterns of fMRI activity in human visual cortex
    David D Cox
    Rowland Institute for Science, Cambridge, MA 02142, USA
    Neuroimage 19:261-70. 2003
    ....
  85. pmc The frequency of visually induced γ-band oscillations depends on the size of early human visual cortex
    D Samuel Schwarzkopf
    Wellcome Trust Centre for Neuroimaging, University College London UCL Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 32:1507-12. 2012
    ..We propose that individual differences in macroscopic gamma frequency may be attributed to interindividual variability in the microscopic architecture of visual cortex.
  86. pmc Local diversity and fine-scale organization of receptive fields in mouse visual cortex
    Vincent Bonin
    Department of Neurobiology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:18506-21. 2011
    ..For example, are neurons in mouse visual cortex--whose preferred orientations are arranged randomly--organized with respect to other response properties? ..
  87. ncbi Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey
    D G Amaral
    Department of Psychiatry, Center for Neuroscience, 1544 Newton Court, Davis, CA 95616, USA
    Neuroscience 118:1099-120. 2003
    ..cells, in the intermediate and parvicellular regions, project to more rostral and medial portions of the visual cortex. These results suggest that the amygdala may have substantial modulatory control over sensory processing at ..
  88. pmc Attention reduces stimulus-driven gamma frequency oscillations and spike field coherence in V1
    Matthew Chalk
    School of Informatics, University of Edinburgh, Edinburgh, UK
    Neuron 66:114-25. 2010
    ..This decrease could reflect an attention-mediated reduction of surround inhibition. Changes in synchrony in V1 would thus be a byproduct of reduced inhibitory drive, rather than a mechanism that directly aids perceptual processing...
  89. pmc Sound-driven synaptic inhibition in primary visual cortex
    Giuliano Iurilli
    Department of Neuroscience and Brain Technologies, Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
    Neuron 73:814-28. 2012
    ..cortex by a noise burst drove local GABAergic inhibition on supragranular pyramids of the mouse primary visual cortex, via cortico-cortical connections...
  90. ncbi Development of direction selectivity in mouse cortical neurons
    Nathalie L Rochefort
    Institute of Neuroscience and Center for Integrated Protein Science, Technical University Munich, Biedersteinerstrasse 29, 80802 Munich, Germany
    Neuron 71:425-32. 2011
    Previous studies of the ferret visual cortex indicate that the development of direction selectivity requires visual experience...
  91. ncbi Circuits for local and global signal integration in primary visual cortex
    Alessandra Angelucci
    Department of Ophthalmology and Visual Science, Moran Eye Center, University of Utah, Salt Lake City, Utah 84132, USA
    J Neurosci 22:8633-46. 2002
    Contrast-dependent changes in spatial summation and contextual modulation of primary visual cortex (V1) neuron responses to stimulation of their receptive field reveal long-distance integration of visual signals within V1, well beyond ..
  92. pmc A specific requirement of Arc/Arg3.1 for visual experience-induced homeostatic synaptic plasticity in mouse primary visual cortex
    Ming Gao
    Department of Biology, College of Chemical and Life Sciences, University of Maryland, College Park, Maryland 20742, USA
    J Neurosci 30:7168-78. 2010
    Visual experience scales down excitatory synapses in the superficial layers of visual cortex in a process that provides an in vivo paradigm of homeostatic synaptic scaling...
  93. pmc Sounds reset rhythms of visual cortex and corresponding human visual perception
    Vincenzo Romei
    Institute of Neuroscience and Psychology, University of Glasgow, 58 Hillhead Street, Glasgow G12 8QB, UK
    Curr Biol 22:807-13. 2012
    ..We presented brief sounds and concurrently recorded electroencephalography (EEG) and/or probed visual cortex excitability (phosphene perception) through occipital transcranial magnetic stimulation (TMS)...
  94. ncbi Linking retinotopic fMRI mapping and anatomical probability maps of human occipital areas V1 and V2
    A M Wohlschlager
    Institut fur Medizin, Forschungszentrum Julich, Germany
    Neuroimage 26:73-82. 2005
    ....
  95. pmc Mechanisms underlying development of visual maps and receptive fields
    Andrew D Huberman
    Department of Neurobiology, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Annu Rev Neurosci 31:479-509. 2008
    ..the mechanisms by which spontaneous activity in the developing retina, lateral geniculate nucleus, and visual cortex instruct the axonal and dendritic refinements that give rise to orderly connections in the visual system...
  96. ncbi Spatial and temporal receptive fields of geniculate and cortical cells and directional selectivity
    R L De Valois
    Department of Psychology, University of California, 3210 Tolman Hall 1650, 94720 1650, Berkeley, CA, USA
    Vision Res 40:3685-702. 2000
    ....
  97. ncbi Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest
    Amir Shmuel
    Montreal Neurological Institute, Departments of Neurology and Neurosurgery and Biomedical Engineering, McGill University, Montreal, QC, Canada
    Hum Brain Mapp 29:751-61. 2008
    ..BOLD fluctuations in widespread areas in visual cortex of both hemispheres were significantly correlated with neuronal activity from a single recording site in V1...
  98. ncbi When is early visual cortex activated during visual mental imagery?
    Stephen M Kosslyn
    Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
    Psychol Bull 129:723-46. 2003
    Although many neuroimaging studies of visual mental imagery have revealed activation in early visual cortex (Areas 17 or 18), many others have not...
  99. ncbi Experience-dependent transfer of Otx2 homeoprotein into the visual cortex activates postnatal plasticity
    Sayaka Sugiyama
    Lab for Neuronal Circuit Development, RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Cell 134:508-20. 2008
    Neural circuits are shaped by experience in early postnatal life. Distinct GABAergic connections within visual cortex determine the timing of the critical period for rewiring ocular dominance to establish visual acuity...
  100. ncbi Language-specific tuning of visual cortex? Functional properties of the Visual Word Form Area
    Laurent Cohen
    Institut de Neurologie, Hopital de la Salpetriere, AP HP, Paris, France
    Brain 125:1054-69. 2002
    ..Moreover, activations in the precuneus and the left thalamus were observed when subjects were reading RVF versus left visual field (LVF) words, and are likely to reflect the attentional component of the RVF advantage...
  101. ncbi Inhibition, spike threshold, and stimulus selectivity in primary visual cortex
    Nicholas J Priebe
    Section of Neurobiology, University of Texas at Austin, 1 University Station C0920, Austin, TX 78712, USA
    Neuron 57:482-97. 2008
    Ever since Hubel and Wiesel described orientation selectivity in the visual cortex, the question of how precise selectivity emerges has been marked by considerable debate. There are essentially two views of how selectivity arises...

Research Grants76

  1. Structural correlates of rapid cortical plasticity
    Mriganka Sur; Fiscal Year: 2010
    ..Primary visual cortex (V1) has been a proving ground for describing the phenomena and mechanisms of activity- dependent plasticity ..
  2. DYNAMIC PROPERTIES OF ADULT VISUAL CORTEX--ROLE OF NO
    Michael Friedlander; Fiscal Year: 2003
    ..The adult visual cortex was thought to be less susceptible to peripheral effects and less able to functionally reorganize in an ..
  3. GABAergic Circuits Critical period in Visual Cortex
    Z Huang; Fiscal Year: 2005
    ..The cellular and molecular mechanisms underlying the critical period plasticity in visual cortex will provide insight into the development of other sensory and cognitive functions, learning and memory, ..
  4. DEVELOPMENT AND PLASTICITY OF THE VISUAL SYSTEM
    MICHAEL STRYKER; Fiscal Year: 2004
    ..the mechanisms by which patterns of neural activity guide the development and plasticity of the mammalian visual cortex. Our previous research has shown that spontaneous neural activity in the visual system is required for the ..
  5. Neurotoxicity of Methylmercury in the Visual Cortex
    Yukun Yuan; Fiscal Year: 2007
    ..Corresponding to the visual deficits are region-selective pathological lesions in the visual cortex. The underlying mechanisms for these impairments remain poorly understood, although it appears that the MeHg-..
  6. Vision Sciences Training Grant
    Carol A Mason; Fiscal Year: 2013
    ..Biomedical Engineering and Neuroscience, with 6 investigators in the Mahoney Center studying the primate visual cortex;they use an fMRI facility in the Neurological Institute, and participate in the Center for Theoretical ..
  7. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..nucleus (dLGN) serves as the primary thalamic relay for the transfer of retinal information to primary visual cortex. In addition to sensory signaling, thalamocortical circuits are involved in alterations of behavioral states (..
  8. Mechanisms and Therapeutics for Rett Syndrome
    Mriganka Sur; Fiscal Year: 2013
    ..maturation and circuit plasticity through intracellular electrophysiology in vitro and optical imaging of visual cortex in vivo during experience-dependent plasticity...
  9. DETERMINATION OF NEURONAL FATES IN VISUAL CORTEX
    Susan K McConnell; Fiscal Year: 2013
    ..of this research is to understand the cellular and molecular processes by which young neurons in the mammalian visual cortex achieve their adult identities during development, migrate to appropriate positions, and form axonal ..
  10. Structural determinants of DTI observations in developing cortex and white matter
    Christopher D Kroenke; Fiscal Year: 2013
    ..enucleation because this manipulation is known to induce abnormal patterns of neural connections in the visual cortex of altricial species such as rodents and ferrets...
  11. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..nucleus (dLGN) serves as the primary thalamic relay for the transfer of retinal information to primary visual cortex. In addition to sensory signaling, thalamocortical circuits are involved in alterations of behavioral states (..
  12. Alcohol and Development of the Prefrontal Cortex
    LEON GARLAND COLEMAN; Fiscal Year: 2011
    ..of unique high environment regulated plasticity occurs for many brain regions with the most studied being visual cortex. During these "critical periods of plasticity", developmental processes result in the formation of persisting ..
  13. Neurochemical and metabolic regulation in the visual cortex
    MARGARET TT WONG-RILEY; Fiscal Year: 2013
    ..They will also provide the basis for future gene therapy for visual deficits resulting from faulty energy metabolism. ..
  14. Control of Excitatory Synapse Formation and Maturation by Astrocytes
    WILLIAM CHRISTOPHER RISHER; Fiscal Year: 2013
    ..imaging, serial section EM and electrophysiology in both purified cortical neurons and slice preparations from visual cortex, the proposed work should provide new molecular insight into the role of astrocytes in excitatory ..
  15. Cross-modal re-organization in children with cochlear implants
    Julia Dee Campbell; Fiscal Year: 2013
    ..By presenting visual stimuli to implanted children, visual cortex becomes activated and may be observed as a response in the occipital lobe through topographic scalp maps of ..
  16. FETAL AND POSTNATAL DEVELOPMENT OF VISUAL CONNECTIONS
    Carla J Shatz; Fiscal Year: 2013
    ..release the brake" on ocular dominance (OD) plasticity, a form of experience-dependent synaptic plasticity in visual cortex? In the immune system PirB is a receptor for Major Histocompatibility Class I molecules, famous ligands for T-..
  17. Cell type-based genomics of developmental plasticity in cortical GABA interneuron
    Z Josh Huang; Fiscal Year: 2010
    ..For example, maturation of inhibitory circuitry in primary visual cortex (V1) promotes the development of ocular dominance (OD) plasticity and its critical period, but the cellular ..
  18. FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEX
    Christoph E Schreiner; Fiscal Year: 2013
    ..These properties bear some similarities to emergent processing features in simple and complex cells of primary visual cortex. The goal is to characterize these features and compare their properties across cortical fields and across ..
  19. EnerCage: A Scalable Array of Intelligent Wireless Sensor Modules to Energize and
    Maysam Ghovanloo; Fiscal Year: 2010
    ..It has provided groundbreaking information on areas ranging from the organization of primary visual cortex to neural correlates of working memory, which has helped in the treatment of disorders ranging from ..
  20. DEVELOPMENTAL REGULATION OF GLUTAMATE RECEPTOR FUNCTION
    MARTHA NA CONSTANTINE-PATON; Fiscal Year: 2012
    ..In visual cortex cultures we will characterize the engineered receptors'binding characteristics and targeting...
  21. Development of Synaptic Plasticity in Visual Cortex
    Michael J Friedlander; Fiscal Year: 2010
    ..In particular, the neurons of the primary visual cortex can use such synaptic plasticity to perform parallel computations on aspects of visual processing...
  22. Noninvasive Study of Cerebral ATP Metabolism, Bioenergetics and Brain Function
    Wei Chen; Fiscal Year: 2013
    ..to conduct functional studies using visual stimulation to examine if CMRATP increases in the activated visual cortex for supporting higher energy demand and stimulus-evoked neuronal activity;4) to conduct extracellular neuron-..
  23. REM mechanisms in neocortical development
    Marcos G Frank; Fiscal Year: 2013
    ..by quantitatively measuring and manipulating vigilance states and binocular visual input to primary visual cortex in the freely-behaving animal...
  24. Role of glial glutamate transporters in V1 plasticity and development
    Jeremy C Petravicz; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neuronal networks in the visual cortex integrate synaptic inputs to make complex outputs that underlie vision...
  25. HDAC4-mediated Photoreceptor Protection in Retinal Degeneration
    Bo Chen; Fiscal Year: 2013
    ..restore visual function using: 1) electrophysiology to test the integrity of neural circuits in the retina and visual cortex;2) behavioral tests to determine whether rescued retinal function can guide complex behaviors...
  26. Sleep, proprioception, and forebrain activity in infant mutant mice
    MARK SAMUEL BLUMBERG; Fiscal Year: 2013
    ..and between neocortex and hippocampus, just as retinal waves are thought to contribute to the development of visual cortex and related structures...
  27. Cell Type-Specific Synaptic Defects in Angelman Syndrome Model Mice
    Michael L Wallace; Fiscal Year: 2012
    ..I will use an AS model mouse and take advantage of the well-characterized circuitry of the visual cortex to determine the synaptic basis for the seizures in AS patients...
  28. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..motor and premotor regions and the insula, areas that are overactive during tics, as compared to primary visual cortex, an area not activated by tic behavior...
  29. STRUCTURAL BASIS OF AMBLYOPIA AND STRABISMUS
    Jonathan C Horton; Fiscal Year: 2012
    ..advantage of pursuing experiments in nonhuman primates is that one can perform microelectrode studies in the visual cortex to probe the neural basis of visual suppression...
  30. Regulation of synaptic plasticity by eCBs in adult and aged mammalian cortex
    Karen L Montey; Fiscal Year: 2012
    ..Interestingly, application of GABA agonists directly to the aged visual cortex induces an immediate increase in stimulus selectivity, suggesting the decline in stimulus selectivity may be ..
  31. A 2-photon/confocal microscope for imaging of neural development and function
    Wesley J Thompson; Fiscal Year: 2010
    ..These investigations include an NEI-funded study of normal binocular integration in visual cortex and its disruption by strabismus, an NIDCD-funded study of membrane conductances, synaptic placement, and ..
  32. Global synaptic plasticity mechanisms in visual cortex
    Hey Kyoung Lee; Fiscal Year: 2013
    ..provided by applicant): Visual experience can produce long-lasting changes in the function of the primary visual cortex (V1), especially during a critical period early in postnatal life...
  33. Cortical Structure and Function in Blindness and following Restored Vision
    Geoffrey Karl Aguirre; Fiscal Year: 2013
    ..e., activation to an auditory stimulus), and have altered cortical structure (i.e., atrophy of the visual cortex white matter and disruption of white matter fiber coherence along the optic radiations), we also find enormous ..
  34. Combining cerebral lesions & monkey fMRI for studying cortical network function
    STELIOS MANOLIS SMIRNAKIS; Fiscal Year: 2010
    ..Posterior circulation infarcts, hemorrhages or traumatic brain injury often injure the primary visual cortex (V1) resulting in partial or complete hemianopsias, which are considerably disruptive to vision- dependent ..
  35. PHOTOTRANSDUCTION ENZYMES
    KRZYSZTOF NMI PALCZEWSKI; Fiscal Year: 2013
    ..This signal is eventually relayed to the visual cortex of the brain, where visual perception occurs...
  36. Binocular Approaches to Perceptual Learning in Adult Amblyopia
    CRISTINA LLERENA LAW; Fiscal Year: 2013
    ..If uncorrected, amblyopia results in the unaffected eye controlling the binocular visual cortex, while the ability f the affected eye to stimulate cortical neurons may weaken to the point of functional ..
  37. Development of Visual Pathways
    Hwai Jong Cheng; Fiscal Year: 2013
    ..segregated into layers in the lateral geniculate nucleus, and into ocular dominance columns in primary visual cortex. During the past half century, the development of this segregation has served as a premier model for the ..
  38. Role of Arc in synaptic/experience-dependent plasticity in mouse visual cortex
    JASON DENNIS SHEPHERD; Fiscal Year: 2012
    ..The visual cortex is an ideal preparation to probe these questions as visual experience can be modulated to induce gross changes ..
  39. Neural and Cognitive Correlates of Methamphetamine Use in Schizophrenia
    RUTH EILEEN SALO; Fiscal Year: 2012
    ..Rostral;and 3) Caudal anterior cingulate cortex (rACC and cACC);as well as 4) a control region the primary visual cortex (PVC)...
  40. Understanding feature-based auditory-visual interactions.
    Satoru Suzuki; Fiscal Year: 2013
    ..signals influence neural activation throughout the visual pathways including in the mid brain and primary visual cortex. It is therefore important to extend the rigorous theories of vision to integrate multimodal contexts...
  41. Floating Light Activated Micro-Electrical Stimulators for Neural Prosthetics
    Mesut Sahin; Fiscal Year: 2012
    ..of the cochlear nucleus, midbrain, or auditory cortex to restore hearing, and stimulation of the visual cortex in the blind subjects...
  42. Phase 1/2 Trial of rAAV2-CB-hRPE65 (BB-IND 13848, 11 Sep 2009) for Leber Congenit
    Jeffrey D Chulay; Fiscal Year: 2013
    ..by a nondetectable electroretinogram (ERG) but with relatively preserved photoreceptor structure and an intact visual cortex that is responsive to high intensity light stimulation...
  43. Role of Arc in synaptic/experience-dependent plasticity in mouse visual cortex
    JASON DENNIS SHEPHERD; Fiscal Year: 2013
    ..The visual cortex is an ideal preparation to probe these questions as visual experience can be modulated to induce gross changes ..
  44. Molecular regulation of experience-dependent synapse and dendrite stabilization
    JENNIFER HELEN LESLIE; Fiscal Year: 2010
    ..activity-dependent stabilization of synapses and dendrites during neuronal circuit formation in the developing visual cortex of a cpg15 knockout mouse...
  45. An In Vivo/In Vitro 2-Photon Uncaging/Imaging Microscope
    Martha Constantine Paton; Fiscal Year: 2010
    ..the development of brain ventricles, studies of the role of inhibitory interneurons and astrocytes in visual cortex dynamics, spine dynamics in mouse models of autism and schizophrenia, and the contribution of postsynaptic ..
  46. Interaction of Visual and Oculomotor Signals in Cortex
    Tirin Moore; Fiscal Year: 2013
    ..saccades to pursue the relationship between saccade target selection and neural correlates of attention in visual cortex. Specifically, we will study the influence of saccade preparation on neural correlates of bottom-up and ..
  47. Alcohol in Neocortex Development and Plasticity
    ALEXANDRE ESTEVES MEDINA; Fiscal Year: 2013
    ..We showed that third trimester alcohol exposure lead to a persistent disruption in visual cortex organization and neuronal plasticity...
  48. Biological Spatial Resolution Limits in fMRI
    JONATHAN RIZZO POLIMENI; Fiscal Year: 2013
    ..The long-term objective of this project is to enable non-invasive imaging of fine-scale details of the human visual cortex, including the distinctive spatial maps of orientation preference, ocular dominance, and retinotopy, with a ..
  49. CRCNS: Collaborative Research: Model-Based Control of Spreading Depression
    Steven J Schiff; Fiscal Year: 2013
    ..The project starts by developing an experimental preparation using a tangential 2-dimensional visual cortex rodent brain slice...
  50. Imaging PTEN-induced changes in adult cortical structure and function in vivo
    Joshua Trachtenberg; Fiscal Year: 2012
    ..to guide the placement of in vivo whole cell patch recordings from growing neurons in the mouse primary visual cortex. We also use 2-photon imaging to image network activity in the cortex of knockout and wildtype mice...
  51. Regulation of Spine Morphogenesis by NrCAM
    Patricia F Maness; Fiscal Year: 2013
    ..responses will be measured in star pyramidal neurons, the principal target of thalamocortical input to visual cortex (layer 4), in visual cortical slices of WT and NrCAM null mutant mice by whole cell recordings, and the effect ..
  52. Interaction of Visual and Oculomotor Signals in Cortex
    Tirin Moore; Fiscal Year: 2009
    ..saccades to pursue the relationship between saccade target selection and neural correlates of attention in visual cortex. Specifically, we will study the influence of saccade preparation on neural correlates of bottom-up and ..
  53. CRCNS: Neural Reprensentation of Hierarchical Visual Concepts in Natural Scenes
    Alan L Yuille; Fiscal Year: 2013
    ..that sparse coding ideas can help predict receptive field properties of 'simple cells'in the visual cortex. This proposal has three stages...
  54. A molecular genetic analysis of cortical plasticity
    Elly Nedivi; Fiscal Year: 2013
    ..whether cpg15 is required for synapse and dendrite stabilization and experience-dependent plasticity during visual cortex development, and whether the source of CPG15 is thalamic or cortical...
  55. EXPERIMENTS ON THE DEVELOPMENT OF NEURAL PATHWAYS
    Martha Constantine Paton; Fiscal Year: 2010
    ..maturation and plasticity in the superficial visual layers of the superior colliculus (sSC) and in the visual cortex (VC) neurons projecting to the sSC, the corticotectal projection (CTP)...
  56. Inhibitory plasticity in visual cortical circuits
    Arianna Maffei; Fiscal Year: 2013
    ..2002;Hensch, 2005). In primary visual cortex, one of the best studied models for experience-dependent plasticity, synapse specific forms of plasticity such ..
  57. Disparity Processing in Human Visual Cortex
    Anthony M Norcia; Fiscal Year: 2013
    ....
  58. Organization and Function of Mouse Visual Cortical Areas
    Edward M Callaway; Fiscal Year: 2013
    ..provided by applicant): Visual perception is mediated by complex interactions amongst neurons in the retina, visual cortex, and subcortical brain structures...
  59. Cross-modal changes in auditory cortex circuitry after visual deprivation
    EMILY ROSE PETRUS; Fiscal Year: 2013
    ..These cross-modal changes are correlated with functional recruitment of the visual cortex for processing the remaining senses...
  60. Mechanisms and behavioral relevance of reward timing in the primary visual cortex
    EMMA BERYL ROACH; Fiscal Year: 2010
    ..A novel form of reward-related plasticity was recently observed in the primary visual cortex (V1) of adult rats trained to associate visual stimulation with water reward: neurons that previously reported ..
  61. Neural Coding of Complex 3D Shapes
    Charles E Connor; Fiscal Year: 2013
    ..neural basis of 3D object perception, memory, and cognition, by measuring neural responses in inferotemporal visual cortex (IT), memory-related perirhinal and entorhinal cortex (PR and ER), and decision-related dorsolateral ..
  62. Cortical representations and plasticity: Neurons and astrocytes
    Mriganka Sur; Fiscal Year: 2011
    ..Neurons in primary visual cortex (V1) are selective for multiple features of visual stimuli, for example orientation and spatial frequency, and ..
  63. CRCNS: Higher-order feature detection in olfactory bulb
    Thomas A Cleland; Fiscal Year: 2013
    ..output patterns selective for certain higher-order features of odors in the same sense that neurons in primary visual cortex are selective for higher-order visual features such as edge and orientation - that is, they reflect the co-..
  64. Developmental and experience-dependent changes in synaptic plasticity
    JACQUELINE DEMARCHENA; Fiscal Year: 2010
    ..To discriminate subunit-specific functions, I will take advantage of the murine primary visual cortex, which not only undergoes this subunit transition, but is also heavily sculpted by NMDAR-dependent plasticity...
  65. In Vivo Imaging of Neuronal Plasticity in Mouse Visual Cortex
    Elly Nedivi; Fiscal Year: 2012
    ..Using this system we have imaged and reconstructed the dendritic trees of neurons in visual cortex of thy1-GFP transgenic mice...
  66. Regulation of feedforward retinogeniculate development by cortical feedback
    Andrew D Thompson; Fiscal Year: 2013
    ..stage of development at this synapse that overlaps temporally with critical periods in visual cortex. This observation brings into question the traditional model of feed-forward development of sensory systems, ..
  67. Linking decisions and attention: Optogenetic tests in primate V1 and V4
    Hendrikje Nienborg; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: Relevance to public health The "read-out" of visual cortex serves as a model system for interpretation, decision-making and reasoning...
  68. Assessing space and feature based attention with fMRI and multivoxel pattern anal
    John Serences; Fiscal Year: 2010
    ..techniques that are sensitive to changes in population response profiles across feature-selective regions of visual cortex. Specifically, we present a method for measuring feature-selective `tuning-functions'within very small ..
  69. Plasticity of the Visual Cortex
    Stelios Smirnakis; Fiscal Year: 2006
    ..magnetic resonance (fMRI) to study the process of reorganization triggered by an acute retinal scotoma in the visual cortex of human and non-human primates (macaca mulatta)...
  70. ANATOMY OF IDENTIFIED CELL POPULATIONS IN VISUAL CORTEX
    BARBARA MC GUIRE; Fiscal Year: 1991
    The primate visual cortex is a layered structure, each layer containing many different types of neurons...
  71. REGULATION OF NEURAL PLASTICITY IN MATURING VISUAL CELLS
    Takuji Kasamatsu; Fiscal Year: 1993
    ..Taking advantage of plasticity-enhancing effects of 1-noradrenaline (1- NA) directly infused into aplastic visual cortex of anesthetized and paralyzed kittens, we want to explore a new strategy with which we can quickly alter ..
  72. A comparative study of visual cortex in diurnal and nocturnal rodents.
    KATHARINE CAMPI; Fiscal Year: 2009
    The organization of rodent visual cortex is particularly relevant because rodents are the predominant model for most laboratory studies, including behavioral studies, whole animal physiology, slice physiology, anatomical and molecular ..
  73. ALTERED METABOLISM OF PRIMATE VISUAL CORTEX IN AMBLYOPIA
    Jonathan Horton; Fiscal Year: 1990
    ..However, little no direct information is available about the pathological changes that occur in the human visual cortex in amblyopia, in part because most of the experimental techniques developed for animal studies cannot be used ..
  74. VISUAL ADAPTATION AT MESOPIC LIGHT LEVELS
    Arthur Shapiro; Fiscal Year: 2000
    ..accepted that the clinical pathology in amblyopia involves a functional weakening of connections between the visual cortex and one or both of the eyes...
  75. PERIODIC EXTRINSIC CONNECTIONS IN VISUAL CORTEX
    Kathleen Rockland; Fiscal Year: 1993
    Extrastriate visual cortex is made up of multiple areas differing in their topography, anatomical connectivity, and neuronal response properties...
  76. NEURAL BASIS OF VISUAL PATTERN APPEARANCE
    David Heeger; Fiscal Year: 2006
    Over the past few years, we have come to learn that early visual cortex does not act as a passive image processing machine simply devoted to representing bottom up sensory signals...