frontal lobe

Summary

Summary: The anterior part of the cerebral hemisphere.

Top Publications

  1. pmc A core system for the implementation of task sets
    Nico U F Dosenbach
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 50:799-812. 2006
  2. doi Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
  3. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
  4. ncbi Anterior cingulate cortex, error detection, and the online monitoring of performance
    C S Carter
    Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Science 280:747-9. 1998
  5. ncbi Increased activity in human visual cortex during directed attention in the absence of visual stimulation
    S Kastner
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuron 22:751-61. 1999
  6. ncbi The architecture of cognitive control in the human prefrontal cortex
    Etienne Koechlin
    Institut National de la Sante et de Recherche Medicale, Universite Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France
    Science 302:1181-5. 2003
  7. pmc The role of the right inferior frontal gyrus: inhibition and attentional control
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Neuroimage 50:1313-9. 2010
  8. ncbi Perisylvian language networks of the human brain
    Marco Catani
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AZ, United Kingdom
    Ann Neurol 57:8-16. 2005
  9. ncbi Connectivity-Based Parcellation of Broca's Area
    A Anwander
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Cereb Cortex 17:816-25. 2007
  10. ncbi Frontal lobe contributions to theory of mind
    V E Stone
    University of Cambridge, Department of Experimental Psychology, Cambridge, CB2 3EB, UK
    J Cogn Neurosci 10:640-56. 1998

Detail Information

Publications372 found, 100 shown here

  1. pmc A core system for the implementation of task sets
    Nico U F Dosenbach
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 50:799-812. 2006
    ..Prefrontal regions commonly related to task control carried task-set signals in a smaller subset of tasks and lacked convergence across signal types...
  2. doi Alterations in frontal lobe tracts and corpus callosum in young children with autism spectrum disorder
    Ajay Kumar
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, Detroit Medical Center, Wayne State University, School of Medicine, Detroit, Michigan 48201, USA
    Cereb Cortex 20:2103-13. 2010
    Major frontal lobe tracts and corpus callosum (CC) were investigated in 32 children with autism spectrum disorder (ASD, mean age: 5 years), 12 nonautistic developmentally impaired children (DI, mean age: 4...
  3. ncbi The role of the medial frontal cortex in cognitive control
    K Richard Ridderinkhof
    Department of Psychology, University of Amsterdam, Roetersstraat 15, 1018 WB Amsterdam, Netherlands
    Science 306:443-7. 2004
    ....
  4. ncbi Anterior cingulate cortex, error detection, and the online monitoring of performance
    C S Carter
    Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Science 280:747-9. 1998
    ..It has been proposed that the anterior cingulate cortex (ACC), on the medial surface of the frontal lobe, contributes to performance monitoring by detecting errors...
  5. ncbi Increased activity in human visual cortex during directed attention in the absence of visual stimulation
    S Kastner
    Laboratory of Brain and Cognition, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Neuron 22:751-61. 1999
    ..The increased activity in visual cortex in the absence of visual stimulation may reflect a top-down bias of neural signals in favor of the attended location, which derives from a fronto-parietal network...
  6. ncbi The architecture of cognitive control in the human prefrontal cortex
    Etienne Koechlin
    Institut National de la Sante et de Recherche Medicale, Universite Pierre et Marie Curie, 9, quai St Bernard, 75005 Paris, France
    Science 302:1181-5. 2003
    ..The results support an unified modular model of cognitive control that describes the overall functional organization of the human lateral PFC and has basic methodological and theoretical implications...
  7. pmc The role of the right inferior frontal gyrus: inhibition and attentional control
    Adam Hampshire
    Medical Research Council Cognition and Brain Sciences Unit, Cambridge, UK
    Neuroimage 50:1313-9. 2010
    ..Our results reveal that the RIFG is recruited when important cues are detected, regardless of whether that detection is followed by the inhibition of a motor response, the generation of a motor response, or no external response at all...
  8. ncbi Perisylvian language networks of the human brain
    Marco Catani
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, DeCrespigny Park, London SE5 8AZ, United Kingdom
    Ann Neurol 57:8-16. 2005
    ..The anatomical findings are also relevant to the evolution of language, provide a framework for Lichtheim's symptom-based neurological model of aphasia, and constrain, anatomically, contemporary connectionist accounts of language...
  9. ncbi Connectivity-Based Parcellation of Broca's Area
    A Anwander
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Cereb Cortex 17:816-25. 2007
    ..For the first time, there is a possibility to investigate the anatomical subdivision of Broca's area noninvasively in the individual living human subject...
  10. ncbi Frontal lobe contributions to theory of mind
    V E Stone
    University of Cambridge, Department of Experimental Psychology, Cambridge, CB2 3EB, UK
    J Cogn Neurosci 10:640-56. 1998
    ..In contrast, no specific theory of mind deficits were evident in the unilateral dorsolateral frontal lesion patients. The dorsolateral lesion patients had difficulty only on versions of the tasks that placed demands on working memory...
  11. doi The evolution of the arcuate fasciculus revealed with comparative DTI
    James K Rilling
    Department of Anthropology, Emory University, 207 Anthropology Building, 1557 Dickey Drive, Atlanta, Georgia 30322, USA
    Nat Neurosci 11:426-8. 2008
    ..This human specialization may be relevant to the evolution of language...
  12. ncbi Virtual in vivo interactive dissection of white matter fasciculi in the human brain
    Marco Catani
    Section of Old Age Psychiatry, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, United Kingdom
    Neuroimage 17:77-94. 2002
    ....
  13. ncbi Sources of mathematical thinking: behavioral and brain-imaging evidence
    S Dehaene
    Unité INSERM 334, Service Hospitalier Frederic Joliot, CEA DSV, 91401 Orsay Cedex, France
    Science 284:970-4. 1999
    ..Mathematical intuition may emerge from the interplay of these brain systems...
  14. ncbi Clinical and pathological diagnosis of frontotemporal dementia: report of the Work Group on Frontotemporal Dementia and Pick's Disease
    G M McKhann
    Department of Neurology, Zanvyl Krieger Mind Brain Institute, Johns Hopkins University School of Medicine, 338 Krieger Hall, 3400 N Charles St, Baltimore, MD 21218 2685, USA
    Arch Neurol 58:1803-9. 2001
    ..In addition, recommendations for the neuropathological criteria of FTD were reviewed, relative to classical neuropathology and modern molecular biology...
  15. ncbi The orbitofrontal cortex and reward
    E T Rolls
    University of Oxford, Department of Experimental Psychology, South Parks Road, Oxford OX1 3UD, UK
    Cereb Cortex 10:284-94. 2000
    ....
  16. doi The multiple-demand (MD) system of the primate brain: mental programs for intelligent behaviour
    John Duncan
    MRC Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge CB2 7EF, UK
    Trends Cogn Sci 14:172-9. 2010
    ..Resembling the structured problem-solving of symbolic artificial intelligence, the mental programs of MD cortex appear central to intelligent thought and action...
  17. ncbi Frontal lobes and human memory: insights from functional neuroimaging
    P C Fletcher
    Research Department of Psychiatry, Cambridge University, Addenbrooke s Hospital, Cambridge, UK
    Brain 124:849-81. 2001
    ..We expect that the neuroimaging techniques will provide an important part of this enterprise...
  18. ncbi Functional MRI of language: new approaches to understanding the cortical organization of semantic processing
    Susan Bookheimer
    Brain Mapping Center, UCLA School of Medicine, 90095, USA
    Annu Rev Neurosci 25:151-88. 2002
    ..These are (a) the role of the left inferior frontal lobe in semantic processing and dissociations from other frontal lobe language functions, (b) the organization of ..
  19. ncbi Frontal lobe inputs to the digit representations of the motor areas on the lateral surface of the hemisphere
    Richard P Dum
    Center for the Neural Basis of Cognition and Department of Neurobiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Neurosci 25:1375-86. 2005
    We examined the frontal lobe connections of the digit representations in the primary motor cortex (M1), the dorsal premotor area (PMd), and the ventral premotor area (PMv) of cebus monkeys...
  20. ncbi Cortical mechanisms of human imitation
    M Iacoboni
    Brain Mapping Center, Neuropsychiatric Institute, Department of Psychiatry, UCLA School of Medicine, Los Angeles, CA 90095 7085, USA
    Science 286:2526-8. 1999
    ..Two areas with these properties were found in the left inferior frontal cortex (opercular region) and the rostral-most region of the right superior parietal lobule...
  21. doi How green is the grass on the other side? Frontopolar cortex and the evidence in favor of alternative courses of action
    Erie D Boorman
    Centre for Functional MRI of the Brain, University of Oxford, Oxford 0X3 9DU, UK
    Neuron 62:733-43. 2009
    ..Collectively, these findings reveal complementary prefrontal computations essential for promoting short- and long-term behavioral flexibility...
  22. ncbi The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis
    A Miyake
    Department of Psychology, University of Colorado at Boulder, 80309-0345, USA
    Cogn Psychol 41:49-100. 2000
    ..and monitoring ("Updating"), and inhibition of prepotent responses ("Inhibition")-and their roles in complex "frontal lobe" or "executive" tasks...
  23. ncbi Encoding predictive reward value in human amygdala and orbitofrontal cortex
    Jay A Gottfried
    Functional Imaging Laboratory, Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Science 301:1104-7. 2003
    ..Thus, differential activity in amygdala and orbitofrontal cortex encodes the current value of reward representations accessible to predictive cues...
  24. doi Functional dissociation in right inferior frontal cortex during performance of go/no-go task
    Junichi Chikazoe
    Department of Physiology, The University of Tokyo School of Medicine, Tokyo, Japan
    Cereb Cortex 19:146-52. 2009
    ..These results indicate that the pIFG and IFJ within the inferior frontal cortex are spatially close but are associated with different cognitive control processes in the go/no-go paradigm...
  25. pmc Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent
    Daniel J Simmonds
    Kennedy Krieger Institute, 707 North Broadway, Baltimore, MD 21205, USA
    Neuropsychologia 46:224-32. 2008
    FMRI studies of response inhibition consistently reveal frontal lobe activation. Localization within the frontal cortex, however, varies across studies and appears dependent on the nature of the task...
  26. doi White matter microstructural abnormalities in the frontal lobe of adults with antisocial personality disorder
    Frederick Sundram
    King s College London, Institute of Psychiatry, Department of Forensic and Neurodevelopmental Science, London, UK Department of Psychiatry, Royal College of Surgeons in Ireland, Dublin, Ireland
    Cortex 48:216-29. 2012
    ..to this tract or are or more widespread, including other tracts which are involved in connectivity with the frontal lobe. We performed whole brain voxel-based analyses on WM fractional anisotropy (FA) and mean diffusivity (MD) maps ..
  27. ncbi Neural systems for recognizing emotion
    Ralph Adolphs
    Division of Cognitive Neuroscience, Department of Neurology, 200 Hawkins Drive, University of Iowa College of Medicine, 52242, USA
    Curr Opin Neurobiol 12:169-77. 2002
    ..Two important mechanisms for recognition of emotions are the construction of a simulation of the observed emotion in the perceiver, and the modulation of sensory cortices via top-down influences...
  28. ncbi Dissociable executive functions in the dynamic control of behavior: inhibition, error detection, and correction
    H Garavan
    Department of Psychology, Trinity College Dublin, Dublin 2, Ireland
    Neuroimage 17:1820-9. 2002
    ..The results highlight how higher cognitive functions responsible for behavioral control can result from the dynamic interplay of distinct cortical systems...
  29. pmc The role of human orbitofrontal cortex in value comparison for incommensurable objects
    Thomas H B FitzGerald
    Wellcome Trust Centre for Neuroimaging, London WC1N 3BG, United Kingdom
    J Neurosci 29:8388-95. 2009
    ..These findings indicate that orbitofrontal cortex plays a pivotal role in valuation for incommensurable goods, a critical component process in human decision making...
  30. ncbi Mapping continued brain growth and gray matter density reduction in dorsal frontal cortex: Inverse relationships during postadolescent brain maturation
    E R Sowell
    Laboratory of Neuro Imaging, Department of Neurology, University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 21:8819-29. 2001
    ..we have mapped the continued postadolescent brain growth that occurs primarily in the dorsal aspects of the frontal lobe bilaterally and in the posterior temporo-occipital junction bilaterally...
  31. ncbi Action sets and decisions in the medial frontal cortex
    M F S Rushworth
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    Trends Cogn Sci 8:410-7. 2004
    ....
  32. pmc Is the rostro-caudal axis of the frontal lobe hierarchical?
    David Badre
    Department of Cognitive and Linguistic Sciences, Brown University, Providence, Rhode Island 02912, USA
    Nat Rev Neurosci 10:659-69. 2009
    ..To address this gap, this Review surveys anatomical, neuroimaging, electrophysiological and developmental findings, and considers the question: could the organization of the frontal cortex be hierarchical?..
  33. ncbi Decreased gray matter concentration in the insular, orbitofrontal, cingulate, and temporal cortices of cocaine patients
    Teresa R Franklin
    Addiction Treatment Research Center, Department of Psychiatry, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, PA 19104 6178, USA
    Biol Psychiatry 51:134-42. 2002
    ..To date, a focal structural analysis of the brains of cocaine patients has not been undertaken...
  34. ncbi An fMRI study of the Trail Making Test
    Konstantine K Zakzanis
    Department of Life Sciences, University of Toronto, Toronto, ON, Canada
    Neuropsychologia 43:1878-86. 2005
    This study investigated the cerebral correlates of the Trail Making Test (TMT), used commonly as a measure of frontal lobe function...
  35. pmc Human medial frontal cortex mediates unconscious inhibition of voluntary action
    Petroc Sumner
    School of Psychology, Cardiff University, Tower Building, Park Place, Cardiff CF10 3AT, UK
    Neuron 54:697-711. 2007
    ..These findings imply that the SEF and SMA mediate automatic effector-specific suppression of motor plans. This automatic mechanism may contribute to the participation of these areas in the voluntary control of action...
  36. ncbi Neuronal correlates of theory of mind and empathy: a functional magnetic resonance imaging study in a nonverbal task
    Birgit A Vollm
    Neuroscience and Psychiatry Unit, University of Manchester, Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Neuroimage 29:90-8. 2006
    ..Studies investigating networks associated with empathic responding also suggest involvement of temporal and frontal lobe regions. In this fMRI study, we used a cartoon task derived from Sarfati et al. (1997) [Sarfati, Y...
  37. ncbi Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli
    J D Jentsch
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, P O Box 208001, New Haven, CT 06520 8001, USA
    Psychopharmacology (Berl) 146:373-90. 1999
    ..The evidence for cognitive impulsivity in drug abuse associated with dysfunction of the frontostriatal system will be discussed, and an integrative hypothesis for compulsive reward-seeking in drug abuse will be presented...
  38. doi The brain basis of language processing: from structure to function
    Angela D Friederici
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Physiol Rev 91:1357-92. 2011
    ..Studies with patients suffering from lesions in the corpus callosum reveal that the posterior portion of this structure plays a crucial role in the interaction of syntactic and prosodic information during language processing...
  39. ncbi The Parieto-Frontal Integration Theory (P-FIT) of intelligence: converging neuroimaging evidence
    Rex E Jung
    Departments of Neurology and Psychology, University of New Mexico, Albuquerque, NM 87106, USA
    Behav Brain Sci 30:135-54; discussion 154-87. 2007
    ..Moreover, the model provides a framework for testing new hypotheses in future experimental designs...
  40. ncbi The involvement of the orbitofrontal cortex in the experience of regret
    Nathalie Camille
    Institut des Sciences Cognitives, CNRS, 67, Boulevard Pinel 69675 Bron, France
    Science 304:1167-70. 2004
    ..Patients with orbitofrontal cortical lesions, however, did not report regret or anticipate negative consequences of their choices. The orbitofrontal cortex has a fundamental role in mediating the experience of regret...
  41. ncbi Beauty in a smile: the role of medial orbitofrontal cortex in facial attractiveness
    J O'DOHERTY
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, 12 Queen Square, London WC1 3BG, UK
    Neuropsychologia 41:147-55. 2003
    ..Responses in this region were further enhanced by a smiling facial expression, suggesting that the reward value of an attractive face as indexed by medial OFC activity is modulated by a perceiver directed smile...
  42. pmc The dorsal medial frontal cortex is sensitive to time on task, not response conflict or error likelihood
    Jack Grinband
    Department of Radiology, Columbia University, New York, NY 10032, USA
    Neuroimage 57:303-11. 2011
    ....
  43. ncbi Inhibition and the right inferior frontal cortex
    Adam R Aron
    Department of Experimental Psychology, Downing Street, University of Cambridge, Cambridge CB2 3EB, UK
    Trends Cogn Sci 8:170-7. 2004
    ..Future research should investigate the generality of this proposed inhibitory function to other task domains, and its interaction within a wider network...
  44. ncbi Lateralization of ventral and dorsal auditory-language pathways in the human brain
    Geoffrey J M Parker
    Imaging Science and Biomedical Engineering, University of Manchester, Manchester M13 9PT, UK
    Neuroimage 24:656-66. 2005
    ..The connections are stronger in the dominant hemisphere, in agreement with previous studies of functional lateralization of auditory-language processing...
  45. ncbi A componential analysis of task-switching deficits associated with lesions of left and right frontal cortex
    Adam R Aron
    Department of Psychiatry, University of Cambridge, UK
    Brain 127:1561-73. 2004
    ..This study localizes two components of the complex task-switching process (inhibition of task-sets and/or responses and top-down control of task-set) to the right IFG/POp and the left MFG respectively...
  46. ncbi Frontotemporal dementia
    David Neary
    Clinical Neuroscience Group, Hope Hospital, Salford, Greater Manchester M6 8HD, UK
    Lancet Neurol 4:771-80. 2005
    ..FTD provides a challenge both for clinical management and for theoretical understanding of its neurobiological substrate...
  47. ncbi Performance monitoring by the anterior cingulate cortex during saccade countermanding
    Shigehiko Ito
    Center for Integrative and Cognitive Neuroscience, Vanderbilt Vision Research Center, Department of Psychology, Wilson Hall, Vanderbilt University, Nashville, TN 37203, USA
    Science 302:120-2. 2003
    Consensus is emerging that the medial frontal lobe of the brain is involved in monitoring performance, but precisely what is monitored remains unclear...
  48. pmc The brain differentiates human and non-human grammars: functional localization and structural connectivity
    Angela D Friederici
    Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstrasse 1a, 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 103:2458-63. 2006
    ..Tractography data revealing differential structural connectivity signatures for these two brain areas provide additional evidence for a segregation of two areas in the left inferior frontal cortex...
  49. ncbi Differential patterns of striatal activation in young children with and without ADHD
    Sarah Durston
    Sackler Institute for Developmental Psychobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Biol Psychiatry 53:871-8. 2003
    ..Cognitive control, defined as the ability to suppress inappropriate thoughts and actions, is compromised in attention-deficit/hyperactivity disorder (ADHD). This study examines the neural basis of this deficit...
  50. pmc Separable learning systems in the macaque brain and the role of orbitofrontal cortex in contingent learning
    Mark E Walton
    Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK
    Neuron 65:927-39. 2010
    ..Nonetheless, OFC-lesioned animals could still approximate choice-outcome associations using a recency-weighted history of choices and rewards...
  51. pmc Speech facilitation by left inferior frontal cortex stimulation
    Rachel Holland
    Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London WC1N 3AR, UK
    Curr Biol 21:1403-7. 2011
    ....
  52. ncbi Left temporoparietal junction is necessary for representing someone else's belief
    Dana Samson
    Behavioural Brain Sciences Centre, School of Psychology Hills Building, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Nat Neurosci 7:499-500. 2004
    ..Here we report evidence from brain-damaged patients showing that, in addition to involvement of the frontal lobes, the left temporoparietal junction is necessary for reasoning about the beliefs of others...
  53. ncbi Modulation of cortical-limbic pathways in major depression: treatment-specific effects of cognitive behavior therapy
    Kimberly Goldapple
    Rotman Research Institute at Baycrest Centre, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
    Arch Gen Psychiatry 61:34-41. 2004
    ..Functional imaging studies of major depressive disorder demonstrate response-specific regional changes following various modes of antidepressant treatment...
  54. pmc Structural anatomy of empathy in neurodegenerative disease
    Katherine P Rankin
    Memory and Aging Center, UCSF Department of Neurology, University of California San Francisco CA 94143 1207, USA
    Brain 129:2945-56. 2006
    ..The results suggest that the right anterior temporal and medial frontal regions are essential for real-life empathic behaviour...
  55. ncbi Cognitive control and parsing: reexamining the role of Broca's area in sentence comprehension
    Jared M Novick
    University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Cogn Affect Behav Neurosci 5:263-81. 2005
    ..and sentence-processing literatures, we defend the following three hypotheses: (1) LIFG is part of a network of frontal lobe subsystems that are generally responsible for the detection and resolution of incompatible stimulus ..
  56. doi Cognitive control, hierarchy, and the rostro-caudal organization of the frontal lobes
    David Badre
    Department of Cognitive and Linguistic Sciences, Brown University, Box 1978, Providence, RI 02912 1978, USA
    Trends Cogn Sci 12:193-200. 2008
    ..Distinctions among these frameworks are considered as a basis for future research...
  57. ncbi Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17
    Matt Baker
    Department of Neuroscience, Mayo Clinic College of Medicine, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
    Nature 442:916-9. 2006
    ..Our results identify mutations in PGRN as a cause of neurodegenerative disease and indicate the importance of PGRN function for neuronal survival...
  58. doi Dissociating the human language pathways with high angular resolution diffusion fiber tractography
    Stephen Frey
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurosci 28:11435-44. 2008
    ..projections from the pars opercularis (area 44) and the pars triangularis (area 45) in the ventrolateral frontal lobe. As in the macaque monkey, area 44 has distinct connections with the rostral inferior parietal lobule via the ..
  59. ncbi Ventromedial frontal cortex mediates affective shifting in humans: evidence from a reversal learning paradigm
    Lesley K Fellows
    Center for Cognitive Neuroscience, University of Pennsylvania, 3815 Walnut St, Philadelphia, PA 19104 6196, USA
    Brain 126:1830-7. 2003
    ..Subjects with lesions of the ventromedial prefrontal cortex were compared with a group with dorsolateral frontal lobe damage, as well as with normal controls on a simple reversal learning task...
  60. ncbi Are amyotrophic lateral sclerosis patients cognitively normal?
    C Lomen-Hoerth
    Department of Neurology, University of California at San Francisco, 94143, USA
    Neurology 60:1094-7. 2003
    ..In many instances, the frontal executive deficits represent the co-occurrence of frontotemporal lobar dementia (FTLD) and ALS...
  61. doi Orbitofrontal dysfunction in patients with obsessive-compulsive disorder and their unaffected relatives
    Samuel R Chamberlain
    Department of Psychiatry, University of Cambridge, Addenbrooke s Hospital, Box 189, Cambridge CB2 0QQ, UK
    Science 321:421-2. 2008
    ....
  62. doi Meta-analysis of brain volume changes in obsessive-compulsive disorder
    Jean Yves Rotge
    Laboratoire Mouvement Adaptation Cognition, CNRS UMR 5227, Université Bordeaux and Service Universitaire de Psychiatrie, Centre Hospitalier Charles Perrens, Bordeaux, France
    Biol Psychiatry 65:75-83. 2009
    ..In this study, we attempted to provide a complete overview of structural alterations in OCD by meta-analyzing magnetic resonance imaging (MRI) data...
  63. doi A quantitative meta-analysis of fMRI studies in bipolar disorder
    Chi Hua Chen
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge GlaxoSmithKline Clinical Unit Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Bipolar Disord 13:1-15. 2011
    ..This review aimed to synthesize current evidence from fMRI studies in midlife adults with BD and to investigate whether there is support for the theoretical models of the disorder...
  64. ncbi Frontal lobe and cognitive development
    Joaquin M Fuster
    Neuropsychiatric Institute and Brain Research Institute, UCLA School of Medicine Los Angeles, California, USA
    J Neurocytol 31:373-85. 2002
    In phylogeny as in ontogeny, the association cortex of the frontal lobe, also known as the prefrontal cortex, is a late-developing region of the neocortex...
  65. ncbi Abstract reward and punishment representations in the human orbitofrontal cortex
    M L Kringelbach
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Nat Neurosci 4:95-102. 2001
    ..These findings indicate that one emotional involvement of the human orbitofrontal cortex is its representation of the magnitudes of abstract rewards and punishments, such as receiving or losing money...
  66. ncbi Continuum of frontal lobe impairment in amyotrophic lateral sclerosis
    Jennifer M Murphy
    Department of Neurology, ALS Center, University of California, San Francisco, CA 94117, USA
    Arch Neurol 64:530-4. 2007
    ..To identify the nature and prevalence of cognitive and behavioral abnormalities in patients with amyotrophic lateral sclerosis (ALS)...
  67. ncbi Improved naming after transcranial direct current stimulation in aphasia
    A Monti
    Neurostimulation Unit, Department of Neurological Sciences, University of Milan, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, Milan, Italy
    J Neurol Neurosurg Psychiatry 79:451-3. 2008
    ..Whereas anodal tDCS and sham tDCS failed to induce any changes, cathodal tDCS significantly improved the accuracy of the picture naming task by a mean of 33.6% (SEM 13.8%)...
  68. pmc White matter lesions impair frontal lobe function regardless of their location
    M Tullberg
    Department of Neurology, School of Medicine, University of California, Davis, USA
    Neurology 63:246-53. 2004
    ....
  69. ncbi Effects of focal frontal lesions on response inhibition
    Terence W Picton
    Rotman Research Institute at Baycrest, Toronto, Ontario M6A 2E1, Canada
    Cereb Cortex 17:826-38. 2007
    ..Lesions to the right ventrolateral prefrontal cortex (Brodmann areas 44, 45, 47) also increased the variability of response, perhaps by disrupting monitoring performance...
  70. pmc Functional connectivity delineates distinct roles of the inferior frontal cortex and presupplementary motor area in stop signal inhibition
    Jeng Ren Duann
    Swartz Center for Computational Neuroscience, Institute of Neural Computation, University of California, San Diego, 92093, USA
    J Neurosci 29:10171-9. 2009
    ..These new findings provided evidence critically differentiating the roles of IFC and preSMA during stop signal inhibition and have important implications for our understanding of the component processes of inhibitory control...
  71. doi Neural representations of subjective reward value
    J Peters
    NeuroimageNord, Department of Systems Neuroscience, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Behav Brain Res 213:135-41. 2010
    ....
  72. ncbi Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    John P Cogswell
    Department of Pharmacogenetics, GlaxoSmithKline Inc, Research Triangle Park, NC 27709, USA
    J Alzheimers Dis 14:27-41. 2008
    ..We additionally recovered miRNAs from cerebrospinal fluid and discovered AD-specific miRNA changes consistent with their role as potential biomarkers of disease...
  73. ncbi Switching from automatic to controlled action by monkey medial frontal cortex
    Masaki Isoda
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, 49 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Neurosci 10:240-8. 2007
    ..Our data suggest that the pre-SMA resolves response conflict so that the desired action can be selected...
  74. doi Electrical stimulation of Broca's area enhances implicit learning of an artificial grammar
    Meinou H de Vries
    University of Munster, Germany
    J Cogn Neurosci 22:2427-36. 2010
    ..This is the first study that demonstrates that tDCS may facilitate acquisition of grammatical knowledge, a finding of potential interest for rehabilitation of aphasia...
  75. ncbi Reduced frontotemporal functional connectivity in schizophrenia associated with auditory hallucinations
    Stephen M Lawrie
    University Department of Psychiatry, Royal Edinburgh Hospital, Morningside Park, Edinburgh, Scotland, UK
    Biol Psychiatry 51:1008-11. 2002
    ..We used functional magnetic resonance imaging (fMRI) to investigate the frontotemporal disconnection hypothesis of schizophrenia...
  76. ncbi Improved memory functioning and frontal lobe maturation between childhood and adolescence: a structural MRI study
    E R Sowell
    University of California, Los Angeles, Department of Neurology, 90095 1769, USA
    J Int Neuropsychol Soc 7:312-22. 2001
    ..Specifically, frontal lobe gray matter thinning was more strongly predictive of delayed verbal memory functioning than was the mesial ..
  77. ncbi The role of left inferior frontal and superior temporal cortex in sentence comprehension: localizing syntactic and semantic processes
    Angela D Friederici
    Max Planck Institute of Cognitive Neuroscience, Leipzig, Germany
    Cereb Cortex 13:170-7. 2003
    ..These data indicate that both semantic and syntactic processes are supported by a temporo-frontal network with distinct areas specialized for semantic and syntactic processes...
  78. pmc Frontal lobe changes occur early in the course of affective disorders in young people
    Jim Lagopoulos
    Clinical Research Unit, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    BMC Psychiatry 12:4. 2012
    ..Contrasts were carried out between controls subjects and patients cohorts with attenuated syndromes and discrete disorders, separately...
  79. ncbi Integration of diverse information in working memory within the frontal lobe
    V Prabhakaran
    Program in Neurosciences, Jordan Hall, Bldg 420, Stanford University, Stanford, California 94305, USA
    Nat Neurosci 3:85-90. 2000
    ..The role of prefrontal cortex in integrating multiple forms of information in working memory may underlie its unique contribution to high-level cognition that demands flexible mental representations...
  80. pmc Neurons in the frontal lobe encode the value of multiple decision variables
    Steven W Kennerley
    Helen Wills Neuroscience Institute and Department of Psychology, University of California, Berkeley, CA 94720 3190, USA
    J Cogn Neurosci 21:1162-78. 2009
    ..This supports the notion that the ACC is an important component of the neural circuitry underlying optimal decision making...
  81. ncbi Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI
    K Rubia
    Medical Research Council Child and Adolescent Psychiatry Unit, Kings College, London, U K
    Am J Psychiatry 156:891-6. 1999
    ....
  82. pmc Theta burst stimulation dissociates attention and action updating in human inferior frontal cortex
    Frederick Verbruggen
    School of Psychology and Cardiff University Brain Research Imaging Centre, Cardiff CF10 3AT, United Kingdom
    Proc Natl Acad Sci U S A 107:13966-71. 2010
    ..This dissociation reconciles competing accounts of prefrontal organization and casts light on the neural architecture of human cognitive control...
  83. ncbi Executive "brake failure" following deactivation of human frontal lobe
    Christopher D Chambers
    University of Melbourne, Melbourne, Australia
    J Cogn Neurosci 18:444-55. 2006
    ..These findings confirm and extend recent reports that the inferior frontal gyrus is vital for mediating response inhibition...
  84. ncbi Top-down versus bottom-up control of attention in the prefrontal and posterior parietal cortices
    Timothy J Buschman
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, and Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 315:1860-2. 2007
    ..This result indicates that top-down and bottom-up signals arise from the frontal and sensory cortex, respectively, and different modes of attention may emphasize synchrony at different frequencies...
  85. ncbi The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology
    Morten L Kringelbach
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK
    Prog Neurobiol 72:341-72. 2004
    ..Finally, we propose new neuroimaging methods for obtaining further evidence on the localisation of function in the human orbitofrontal cortex...
  86. ncbi The human orbitofrontal cortex: linking reward to hedonic experience
    Morten L Kringelbach
    University of Oxford, University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK
    Nat Rev Neurosci 6:691-702. 2005
    ..Here, the functional neuroanatomy of the human orbitofrontal cortex is described and a new integrated model of its functions proposed, including a possible role in the mediation of hedonic experience...
  87. ncbi Transcranial magnetic stimulation can be used to test connections to primary motor areas from frontal and medial cortex in humans
    C Civardi
    Sobell Department of Neurophysiology, Institute of Neurology, Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 14:1444-53. 2001
    ..We conclude that low-intensity TMS over presumed premotor areas of frontal cortex can engage corticocortical connections to the primary motor hand area...
  88. pmc Neurons in the orbitofrontal cortex encode economic value
    Camillo Padoa-Schioppa
    Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 441:223-6. 2006
    ..In this framework, neurons in the OFC seem to be a good candidate network for value assignment underlying economic choice...
  89. ncbi The functions of the orbitofrontal cortex
    Edmund T Rolls
    Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, England, UK
    Brain Cogn 55:11-29. 2004
    ....
  90. doi A systematic review of diffusion tensor imaging studies in affective disorders
    Claire E Sexton
    University Department of Psychiatry and Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom
    Biol Psychiatry 66:814-23. 2009
    ....
  91. ncbi Intelligence and the frontal lobe: the organization of goal-directed behavior
    J Duncan
    MRC Applied Psychology Unit, Cambridge, United Kingdom
    Cogn Psychol 30:257-303. 1996
    ..In this article we suggest that g is largely a reflection of the control functions of the frontal lobe. A series of experiments investigates a phenomenon we call goal neglect: disregard of a task requirement event ..
  92. pmc The role of the lateral frontal cortex in causal associative learning: exploring preventative and super-learning
    Danielle C Turner
    Department of Psychiatry, University of Cambridge, School of Clinical Medicine, Addenbrooke s Hospital, CB2 2QQ, UK
    Cereb Cortex 14:872-80. 2004
    ..Furthermore, its activity is not directly explicable in terms of novelty or response errors and appears directly related to the learning that arises out of prediction error...
  93. ncbi Broca's region revisited: cytoarchitecture and intersubject variability
    K Amunts
    C and O Vogt Institute for Brain Research, Heinrich Heine University, D 40001 Dusseldorf, Germany
    J Comp Neurol 412:319-41. 1999
    ..Such hemispheric and gender differences were not detected in area 45. These morphologic asymmetries of area 44 provide a putative correlate of the functional lateralization of speech production...
  94. pmc Diffusion tensor imaging of frontal lobe in autism spectrum disorder
    Senthil K Sundaram
    Carman and Ann Adams Department of Pediatrics, Children s Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201, USA
    Cereb Cortex 18:2659-65. 2008
    To investigate frontal lobe white matter in children with autism spectrum disorder (ASD), we performed diffusion tensor imaging (DTI) in 50 ASD children (mean age: 57.5 +/- 29...
  95. ncbi Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21
    Marc Cruts
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE 2610 Antwerpen, Belgium
    Nature 442:920-4. 2006
    ..Furthermore, in a Belgian series of familial FTD patients, PGRN mutations were 3.5 times more frequent than mutations in MAPT, underscoring a principal involvement of PGRN in FTD pathogenesis...
  96. ncbi The anatomical connections of the macaque monkey orbitofrontal cortex. A review
    C Cavada
    Departamento de Morfologia, Facultad de Medicina, Universidad Autonoma de Madrid, 28029 Madrid, Spain
    Cereb Cortex 10:220-42. 2000
    ....
  97. ncbi Meeting of minds: the medial frontal cortex and social cognition
    David M Amodio
    Department of Psychology, New York University, 6 Washington Place, New York 10003, USA
    Nat Rev Neurosci 7:268-77. 2006
    ....
  98. ncbi Involvement of the inferior frontal junction in cognitive control: meta-analyses of switching and Stroop studies
    Jan Derrfuss
    Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany
    Hum Brain Mapp 25:22-34. 2005
    ..Finally, our results demonstrate how quantitative meta-analyses can be used to test hypotheses about the involvement of specific brain regions in cognitive control...
  99. doi Basal ganglia and frontal involvement in self-generated and externally-triggered finger movements in the dominant and non-dominant hand
    Félix Etienne François-Brosseau
    Functional Neuroimaging Unit, Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Eur J Neurosci 29:1277-86. 2009
    ..Furthermore, we propose that, for right-handed people performing fine movements, as far as putamen involvement is concerned, the lack of proficiency of the non-dominant hand may prevail over other task demands...
  100. pmc Left inferior frontal cortex and syntax: function, structure and behaviour in patients with left hemisphere damage
    Lorraine K Tyler
    Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Brain 134:415-31. 2011
    ..On this view, the left inferior frontal gyrus may not itself be specialized for syntactic processing, but plays an essential role in the neural network that carries out syntactic computations...
  101. ncbi Pathways that make voices: white matter changes in auditory hallucinations
    Daniela Hubl
    Department of Psychiatric Neurophysiology, University Hospital of Clinical Psychiatry, Bern, Switzerland
    Arch Gen Psychiatry 61:658-68. 2004
    ..Magnetic resonance diffusion tensor imaging is a relatively new in vivo method to investigate the directionality of cortical white matter tracts...

Research Grants75

  1. ANTIPSYCHOTIC DRUGS AND CONTROL OF DOPAMINERGIC NEURONS
    Robert Roth; Fiscal Year: 2006
    ..Long-term abuse of PCP or marijuana is linked with deficits of frontal lobe function providing relevance for our findings in animals...
  2. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..motor coordination and also in the cognitive activities ascribed to the cerebellum's connections with the frontal lobe. Permanent deficits result from these alterations that become more prevalent with age and predispose our ..
  3. Frontal Lobe Injury and Executive Control of Cognition and Emotion
    Diane Swick; Fiscal Year: 2013
    ..The frontal lobes of the brain are particularly vulnerable to damage from TBI, and frontal lobe injuries can lead to a number of serious symptoms that can be disabling to the patients and their families...
  4. Trajectories and Markers of Neurodegeneration in Fragile X Premutation Carriers
    Susan M Rivera; Fiscal Year: 2013
    ..we have demonstrated that abnormal elevation of FMR1 mRNA is associated with reduced hippocampus, amygdala, and frontal lobe function, which in turn are correlated with psychological symptoms and social deficits, impaired memory recall ..
  5. ALL therapy and developing brains: MRI measures, genetic factors and cognition
    Wilburn E Reddick; Fiscal Year: 2013
    ..white matter damage preferentially in the frontal lobes and 2) specific neurocognitive deficits associated with frontal lobe functioning. Imaging alone was unable to accurately predict later neurocognitive deficits...
  6. Brain Development, Behavior and Cognition in Pre- and Postnatal Cocaine Exposure
    Tamara Duckworth Warner; Fiscal Year: 2010
    ..decreases in subcortical structure volumes and differences in the integrity of white matter tracts in the frontal lobe have been reported. Studies of neuropsychological functioning in children with PCE have yielded mixed results...
  7. Mice with Functional Fluorescent Nicotinic Receptor Subunits
    Henry A Lester; Fiscal Year: 2010
    ..disease (PD), and the seizure-suppressing effects of nicotine use in autosomal dominant nocturnal frontal lobe epilepsy...
  8. Diabetes, Cognition and the Brain
    Antonio Convit; Fiscal Year: 2012
    ..Towards this goal we will measure cognition (including memory and frontal lobe measures of performance) with standard neuropsychological tests, hippocampal volumes with validated and ..
  9. Citicoline Treatment of Methamphetamine Dependence
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2010
    ..Most recently, we have found that citicoline tends to decrease MA use and, importantly, to increase frontal lobe N-acetylaspartate (NAA, a marker of neuronal viability or integrity) levels in MA dependent subjects, which ..
  10. fMRI and Cognition in Adolescent Cannabis Users
    Susan F Tapert; Fiscal Year: 2010
    ..g., frontal lobe, hippocampus, striatum, and cerebellum)...
  11. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    Nicholas D Schiff; Fiscal Year: 2013
    ..Neural activity in the monkey's frontal lobe during and following stimulation will also be examined. Dr...
  12. Optimization of the FPI model for epilepsy therapy development
    RAIMONDO D'AMBROSIO; Fiscal Year: 2013
    ..Thus, FPI-induced frontal lobe PTE is a promising model of pharmacoresistant epilepsy for drug screening...
  13. Alpha5 Subunits in Alpha4beta2 Nicotinic Receptors: Assembly and Function
    CRYSTAL N DILWORTH; Fiscal Year: 2012
    ..and Parkinson's disease and the published observation that patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) who smoke have fewer seizures...
  14. Novel, subtype selective potentiators of nicotinic acetycholine receptors
    MARVIN KENNETH SCHULTE; Fiscal Year: 2010
    ..in a broad range of neurological disorders including Alzheimer's disease (AD), Schizophrenia, Autism, Frontal Lobe Epilepsy, Parkinson's disease, Tourette Syndrome and Attention Deficit Disorder...
  15. EPIGENETIC CHANGES IN FRONTAL LOBE OF SCHIZOPHRENICS
    Schahram Akbarian; Fiscal Year: 2009
    ....
  16. The Role of Mu-opioid Receptor Splice Variants in the HIV Disease
    SETH MICHAEL DEVER; Fiscal Year: 2013
    ..expression levels will be examined in uninfected verses HIV infected human brain tissue from frontal cortex, frontal lobe white matter, and basal ganglia as well as in HIV-1 infected verses control primary CNS cell types using the ..
  17. Exercise, Age-Related Memory Decline, and Hippocampal Function.
    Scott A Small; Fiscal Year: 2013
    ..One such intervention is physical exercise, which has been shown to improve both frontal lobe and hippocampal function...
  18. Regional Brain Manganese Accumulation and Functional Consequences in Welders
    Xuemei Huang; Fiscal Year: 2013
    ..g., olfactory bulbs (OB), basal ganglia (BG: i.e., caudate, putamen &GP), frontal lobe (FL: i.e...
  19. Collaboration on Alcohol Self-Administration in Adolescents and Young Adults
    SEAN JOSEPH O'CONNOR; Fiscal Year: 2012
    ..Dresden will also assess the effects alcohol on frontal lobe measures of impulsivity in half the sample population, using the Stop-Signal task performed during fMRI ..
  20. Brain Development, Behavior and Cognition in Pre- and Postnatal Cocaine Exposure
    Tamara Duckworth Warner; Fiscal Year: 2012
    ..decreases in subcortical structure volumes and differences in the integrity of white matter tracts in the frontal lobe have been reported. Studies of neuropsychological functioning in children with PCE have yielded mixed results...
  21. Frontal Lobe Neuroimaging as a Biomarker of Chronic Traumatic Encephalopathy
    JULIE MARIE STAMM; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The goal of this project is to examine frontal lobe cortical and white matter structures in individuals at high risk for having Chronic Traumatic Encephalopathy (CTE) using in vivo neuroimaging ..
  22. REGULATION OF NEURONAL SYNAPTIC COMPONENTS
    Michele Jacob; Fiscal Year: 2009
    ..in developmental and neurodegenerative disorders such as Alzheimer's disease, schizophrenia, nocturnal frontal lobe epilepsy, and autoimmune autonomic neuropathies...
  23. PREMOTOR AREAS IN THE FRONTAL LOBE
    Peter L Strick; Fiscal Year: 2013
    ..We now know that the frontal lobe contains 6 premotor areas...
  24. Psychobiology of Cognitive Development
    Martha Ann Bell; Fiscal Year: 2013
    ..of self-regulated cognition and emotion is promoted not only by certain complements of genes associated with frontal lobe architecture and development, but also by co-occurring socialization experiences within the family...
  25. Contributions of MTHFR Genotype to Frontal Lobe Dysfunction in Schizophrenia
    JOSHUA LAWRENCE ROFFMAN; Fiscal Year: 2013
    ..an NIMH Patient Oriented Research Career Development Award (K23) entitled "Contributions of MTHFR Genotype to Frontal Lobe Dysfunction in Schizophrenia...
  26. Neuro-vascular Disease as a Cause of Impaired Mobility
    Joshua Zebadiah Willey; Fiscal Year: 2013
    ..We will analyze whether these associations remain after including global and regional (frontal lobe versus peri-ventricular for example) measures of white matter hyperintensities and silent brain infarction is ..
  27. Functional Neuroanatomy of Human Fear Conditioning
    Fred J Helmstetter; Fiscal Year: 2011
    ..We will further evaluate our findings related to localized frontal lobe activity specifically related to contingency awareness and declarative memory...
  28. Cortical/Subcortical Circuits in Late-Life Depression
    Anand Kumar; Fiscal Year: 2010
    ..function, working memory, verbal and non-verbal learning and recall -- domains that reflect dorsolateral frontal lobe and subcortical functioning will also be obtained from our patient and control groups...
  29. Brain Imaging &Cognition in Subjects at Risk for Alzheimer's Disease
    Susan Spear Bassett; Fiscal Year: 2013
    ..indicates that the MCI cases are distinguished by elevated levels of vitamin A, smaller volumes of the left frontal lobe and thalamus bilaterally, and reduced fMRI activation in the cingulate and right frontal gyrus...
  30. Effects of Early-Life Stress on Brain Dysfunction in HIV+ Adults: An fMRI Study
    Uraina S Clark; Fiscal Year: 2012
    ..abnormalities in amygdala fMRI BOLD response, and 2) reduce the functional connectivity between amygdala and frontal lobe regions...
  31. Frontal-Subcortical Development, Movement Abnormalities, and Risk for Psychosis
    Vijay A Mittal; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Psychotic disorders such as schizophrenia have been associated with both frontal lobe dysfunction as well as abnormal regulation of subcortical regions...
  32. Cognitive Control, Working Memory and Prefrontal Cortex
    MARK D'ESPOSITO; Fiscal Year: 2013
    ..In humans, frontal lobe function has been extensively researched both through the careful study of neurological patients with focal ..
  33. Structural and Functional CNS Changes in Myotonic Dystrophy Types 1 and 2
    John W Day; Fiscal Year: 2011
    ..comparable MRI and functional CNS changes in DM1 and DM2, implying a toxic RNA cause these effects: 1) loss of frontal lobe volume;2) frontal white matter abnormalities measured by diffusion tensor imaging;3) trends toward altered ..
  34. Neural Correlates of Working Memory Training for HIV Patients
    Linda Chang; Fiscal Year: 2013
    ..WM deficits also may be related to neuroinflammation, frontal lobe dysfunction or decreased dopaminergic function...
  35. Interaction of Alcohol with HIV-Protein
    Norman J Haughey; Fiscal Year: 2011
    ..Alcohol is a common drug of abuse in HIV-infected patients that can worsen the decline of frontal lobe function that is associated with HIV encephalitis...
  36. Aging of Frontal Structure and Function in Down Syndrome and Dementia
    Frederick Schmitt; Fiscal Year: 2013
    ..a 5 year period of time to identify age and dementia-associated changes in cognition and in particular focus on frontal lobe function. Our aims are four-fold...
  37. Brain Development in Adolescents with Genetic Risk Factors for Alcoholism
    DANIEL S O LEARY; Fiscal Year: 2013
    ..The fMRI tasks will focus upon the forebrain reward system, and frontal lobe inhibitory function...
  38. Mechanisms of aging-related extinction deficits
    James R Moyer; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): There is a fundamental gap in understanding how changes in frontal lobe function that emerge in middle age contribute to aging-related deficits in cognitive flexibility...
  39. Role of oscillatory dynamics in prefrontal control of cortical excitability durin
    Kristopher L Anderson; Fiscal Year: 2013
    ..in modulating sensory processing utilizing electroencephalographic (EEG) recordings from patients with focal frontal lobe damage due to stroke as well as age-matched controls...
  40. Disrupted development of neural connections by alcohol initiation in adolescence
    Monica Luciana; Fiscal Year: 2013
    ..To date, found age-related improvements were found in numerous frontal lobe-mediated functions, including planning, delay discounting, inhibitory control, and motivated decision making...
  41. NEUROPHYSIOLOGY IN CHILDREN AT HIGH RISK FOR ALCOHOLISM
    Bernice Porjesz; Fiscal Year: 2013
    ..oscillations (EROs) that underlie ERPs, and provide a window into neuronal network functioning, suggesting frontal lobe dysfunction in alcoholics and HR...
  42. Cognitive and Behavioral Control in FTD
    Joel H Kramer; Fiscal Year: 2013
    ..Patients with bvFTD and other frontal lobe disorders often present with severe behavioral dysfunction despite relatively intact performance on standard ..
  43. Behavioral and neural mechanisms of visual short-term memory
    WHEE KY MA; Fiscal Year: 2013
    ..Deficits in VSTM are found in numerous disorders, including visual neglect, parietal and frontal lobe damage, attention deficit/hyperactivity disorder, and schizophrenia...
  44. 31P magnetization transfer study of bipolar disorder
    Chun S Zuo; Fiscal Year: 2010
    ..We hypothesize that 1) CK enzymatic activity, measured as kfor, in the frontal lobe of depressed BPD subjects will be decreased relative to that of age and sex matched controls;2) the kfor of CK ..
  45. Age effects on episodic memory: Neuropsychology, electrophysiology, and modeling
    Anjali Thapar; Fiscal Year: 2012
    ..By contributing towards a deeper and more integrated understanding of these changes, the results should help address a pervasive and debilitating problem of cognitive aging. ..
  46. Macrostructural and Microstructural Analysis of the Primate Corpus Callosum
    KIMBERLEY ANN PHILLIPS; Fiscal Year: 2010
    ..Capuchins are expected to have significantly less fiber connections to the frontal lobe. However, if the topography of the CC is conserved across the primate Order, then capuchins should show similar ..
  47. Cognitive control and the functional organization of frontal cortex
    David Badre; Fiscal Year: 2013
    ..take advantage of this independence to provide a more explicit definition of abstraction as it relates to frontal lobe function...
  48. Longitudinal neuroimaging of metamphetamine-dependent adolescents
    PERRY FRANKLIN RENSHAW; Fiscal Year: 2012
    ..we wish to evaluate whether MA use during adolescence is associated with long-term adverse effects on frontal lobe structure and function...
  49. Substance Dependent Adolescents: Imaging Risk-Taking
    Thomas J Crowley; Fiscal Year: 2010
    ..white matter volume reductions in right inferior parietal lobule, left inferior parietal lobule, and right frontal lobe, (g) After examining the regions of interest in pre-hoc hypotheses (b) - (f), we also will conduct exploratory ..
  50. Structural and Functional Neuroimaging of the Auditory System in Autism
    Jeffrey I Berman; Fiscal Year: 2013
    ..The fourth and final goal is to investigate the role of input from the frontal lobe on auditory corex activity...
  51. ATTENTION, ORIENTATION, &THE HUMAN PREFRONTAL CORTEX
    ROBERT THOMAS KNIGHT; Fiscal Year: 2013
    ..We will examine three tasks probing hallmarks of frontal lobe function (categorical perception, working memory and controlled vs...
  52. Effects of ethanol concentration in binge drinking during HIV-1 infection
    Sraboni Sarkar; Fiscal Year: 2013
    ..for exposure to HIV infection, but has also been correlated with neurocognitive deficits in working memory and frontal lobe processing in the young population...
  53. Speech sound processing within human auditory cortex during self-vocalization
    JEREMY GREENLEE; Fiscal Year: 2013
    ..alterations during vocalization changes activity recorded from auditory cortex, 3) test the hypothesis that frontal lobe speech areas are functionally connected to the auditory cortical fields that demonstrate vocalization-induced ..
  54. Neurobiological Bases of Economic Choice Behavior
    Camillo Padoa Schioppa; Fiscal Year: 2010
    ..a medical perspective, as choice deficits are often observed in patients with neurological disorders of the frontal lobe and in addiction...
  55. Realtime Near Infrared Spectroscopy of the Frontal Lobe for Neurofeedback
    BLAISE DEBONNEVAL FREDERICK; Fiscal Year: 2011
    ..Specific Aims: 1) Develop an optical helmet optimized for real-time frontal lobe neurofeedback...
  56. ATTENTION, ORIENTATION, &PREFRONTAL CORTEX
    ROBERT THOMAS KNIGHT; Fiscal Year: 2012
    ..We will examine three tasks probing hallmarks of frontal lobe function (categorical perception, working memory and controlled vs...
  57. What language does the motor cortex use to speak to motoneurons?
    Darcy M Griffin; Fiscal Year: 2013
    ..Approximately 50% of the corticospinal neurons from the frontal lobe originate from M1...
  58. BRAIN DYSFUNCTION AND ALCOHOLISM
    Bernice Porjesz; Fiscal Year: 2012
    ..Many of our results related to response inhibition strongly implicate impaired frontal lobe functioning...
  59. White matter maturation and executive function advances in fetal alcohol exposure
    JOHN BENJAMIN COLBY; Fiscal Year: 2013
    ..These actions are thought to be meditated by activity in the frontal lobe, and functional deficits in these areas in children with FASDs may be related to abnormalities in white matter ..
  60. Adolescent Maturation of Brain Network Integration for Executive Control Ability
    Michael C Stevens; Fiscal Year: 2013
    ..are hierarchically-organized, such that `higher-order'systems (which include historically-recognized frontal lobe executive brain regions) exert top-down control over subordinate neural systems...
  61. Modeling External and Internal Influences on Task Choice
    CATHERINE MEIGE ARRINGTON; Fiscal Year: 2011
    ..g. frontal lobe damage, schizophrenia, or ADHD)...
  62. Neural representation of reward in frontal cortex
    Jonathan D Wallis; Fiscal Year: 2013
    ..The frontal lobe is critical to choice behavior since damage to this region produces specific impairments in decision-making...
  63. fMRI Investigations of Cognition in Alcoholics
    John E Desmond; Fiscal Year: 2013
    ..Whereas spatial working memory in alcoholic subjects has revealed decreases in frontal lobe activation, verbal working memory has elicited left frontal and right cerebellar increases in activation...
  64. Brain & Cognitive Changes after Reasoning or Physical Training in Cognitively Nor
    Sandra Bond Chapman; Fiscal Year: 2010
    ..Age-related cognitive decline has consistently been identified on frontal lobe measures of executive control such as reasoning...
  65. Functional Studies of Subtypes of Parkinson's Diseasee
    Xuemei Huang; Fiscal Year: 2007
    ..of PD are tremor, muscle rigidity, bradykmesia, and postural instability; cognitive impairment related to frontal lobe dysfunction also clearly occurs...
  66. CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBS
    WENDY LOMBARDI; Fiscal Year: 2003
    ..stimulation (DBS) in the basal ganglia are mediated through the selective activation of discrete regions of the frontal lobe to which the basal ganglia are connected...
  67. CORTICOSPINAL CONTROL OF FORELIMB MOVEMENT
    Paul Cheney; Fiscal Year: 2002
    ..a proposal requesting five years of support for work concerned with the synaptic and functional organization of frontal lobe cortical areas in the control of forelimb movements in primates...
  68. Frontal/Medial Temporal Lobe Contributions to Memory
    Jeffrey Ojemann; Fiscal Year: 2005
    ..The resulting memory impairment is poorly predictive of postoperative memory decline. Frontal lobe activation in memory could explain these results given the limited perfusion of medial temporal lobe structures ..
  69. Semantic Network Flexibility Modulation/Autism Spectrum
    David Beversdorf; Fiscal Year: 2007
    ..Robert Bornstein, a neuropsychologist experienced in frontal lobe research) and collaborators...
  70. A Mouse Model of Inherited Frontal Lobe Epilepsy
    Jim Boulter; Fiscal Year: 2006
    ..engineered mutant mouse strains that genocopy a human disorder known as autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)...
  71. Fourth International Seizure Prediction Workshop
    Ivan Osorio; Fiscal Year: 2009
    ..Nocturnal Frontal lobe epilepsy: A rare disease with great potential for predictability;2...
  72. Understanding False Recognition in Alzheimer's Disease
    ANDREW BUDSON; Fiscal Year: 2009
    ..Expt. 1 will examine response bias at varying levels of discrimination, and will correlate this bias with frontal lobe function and awareness of the patients'memory deficit. Expt...
  73. BRAIN MORPHOLGY IN OBSESSIVE-COMPULSIVE DISORDER
    Delbert Robinson; Fiscal Year: 1993
    ..blind conditions, on each scan: 1) the premotor, prefrontal and orbital cortical subdivisions as parts of the frontal lobe; 2) the prefrontal and premotor interhemispheric fissure subdivisions (an indirect measure of change in frontal ..
  74. The Neuronal Mechanisms Underlying Choice Behavior in the Frontal Lobe
    Steve Kennerley; Fiscal Year: 2009
    ..Damage to the frontal lobe, including the OFC and the anterior cingulate cortex (ACC), impairs the ability to make optimal choices in our ..
  75. BRAIN RESERVE, AGING, AND WORKING MEMORY
    Marc Haut; Fiscal Year: 1999
    17: Attention and frontal lobe function: Studies of neural mechanisms of age-related changes in attention and frontal lobe executive processes...