nucleus accumbens

Summary

Summary: Collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the so-called ventral striatum, a composite structure considered part of the basal ganglia.

Top Publications

  1. pmc The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Trends Neurosci 33:267-76. 2010
  2. pmc Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens
    Ko Woon Lee
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:3399-404. 2006
  3. pmc Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference
    Darlene H Brunzell
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1993-2001. 2009
  4. doi Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
  5. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
  6. ncbi Anticipation of increasing monetary reward selectively recruits nucleus accumbens
    B Knutson
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1610, USA
    J Neurosci 21:RC159. 2001
  7. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
  8. pmc Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 330:385-90. 2010
  9. doi The glutamate homeostasis hypothesis of addiction
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Nat Rev Neurosci 10:561-72. 2009
  10. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008

Research Grants

  1. Nucleus Accumbens-Mediated Feeding: Output Pathways
    Thomas R Stratford; Fiscal Year: 2010
  2. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  3. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
  4. Diane Lebesgue; Fiscal Year: 2014
  5. David P Gavin; Fiscal Year: 2016
  6. ROBERT MARK WIGHTMAN; Fiscal Year: 2016
  7. JENNIFER ANNE RINKER; Fiscal Year: 2014
  8. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
  9. Scott J Russo; Fiscal Year: 2016
  10. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012

Detail Information

Publications408 found, 100 shown here

  1. pmc The addicted synapse: mechanisms of synaptic and structural plasticity in nucleus accumbens
    Scott J Russo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029 6574, USA
    Trends Neurosci 33:267-76. 2010
    ..Although these structural changes are well documented in nucleus accumbens medium spiny neurons, little is known regarding the underlying molecular mechanisms...
  2. pmc Cocaine-induced dendritic spine formation in D1 and D2 dopamine receptor-containing medium spiny neurons in nucleus accumbens
    Ko Woon Lee
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 103:3399-404. 2006
    Psychostimulant-induced alteration of dendritic spines on dopaminoceptive neurons in nucleus accumbens (NAcc) has been hypothesized as an adaptive neuronal response that is linked to long-lasting addictive behaviors...
  3. pmc Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference
    Darlene H Brunzell
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1993-2001. 2009
    ..Previous studies have implicated nucleus accumbens (NAc) CREB activity in the modulation of cocaine and morphine reward, and have shown that nicotine ..
  4. doi Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder
    Damiaan Denys
    Department of Psychiatry, Academic Medical Center, University of Amsterdam, The Netherlands
    Arch Gen Psychiatry 67:1061-8. 2010
    ..Even when the best available treatments are applied, approximately 10% of patients remain severely afflicted and run a long-term deteriorating course of OCD...
  5. pmc Dnmt3a regulates emotional behavior and spine plasticity in the nucleus accumbens
    Quincey LaPlant
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA
    Nat Neurosci 13:1137-43. 2010
    ..We found that Dnmt3a expression was regulated in mouse nucleus accumbens (NAc) by chronic cocaine use and chronic social defeat stress...
  6. ncbi Anticipation of increasing monetary reward selectively recruits nucleus accumbens
    B Knutson
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1610, USA
    J Neurosci 21:RC159. 2001
    Comparative studies have implicated the nucleus accumbens (NAcc) in the anticipation of incentives, but the relative responsiveness of this neural substrate during anticipation of rewards versus punishments remains unclear...
  7. pmc Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex
    Satoshi Ikemoto
    Behavioral Neuroscience Research Branch, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, Maryland 21224, USA
    Brain Res Rev 56:27-78. 2007
    ..linear nucleus raphe selectively project to the ventromedial striatum (medial olfactory tubercle and medial nucleus accumbens shell), whereas the anteromedial VTA has few if any projections to the ventral striatum, and the lateral VTA ..
  8. pmc Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward
    Mary Kay Lobo
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY 10029, USA
    Science 330:385-90. 2010
    The nucleus accumbens is a key mediator of cocaine reward, but the distinct roles of the two subpopulations of nucleus accumbens projection neurons, those expressing dopamine D1 versus D2 receptors, are poorly understood...
  9. doi The glutamate homeostasis hypothesis of addiction
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Nat Rev Neurosci 10:561-72. 2009
    ..engenders changes in neuroplasticity that impair communication between the prefrontal cortex and the nucleus accumbens. Some of these pathological changes are amenable to new glutamate- and neuroplasticity-based ..
  10. pmc Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
    KELLY L CONRAD
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, Illinois 60064, USA
    Nature 454:118-21. 2008
    ..that excite receptors for alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) in the nucleus accumbens. Here we show that the number of synaptic AMPA receptors in the accumbens is increased after prolonged ..
  11. pmc Cortico-Basal Ganglia reward network: microcircuitry
    Susan R Sesack
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 35:27-47. 2010
    Many of the brain's reward systems converge on the nucleus accumbens, a region richly innervated by excitatory, inhibitory, and modulatory afferents representing the circuitry necessary for selecting adaptive motivated behaviors...
  12. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..emission tomography, we demonstrated that D2/3 receptor availability is significantly reduced in the nucleus accumbens of impulsive rats that were never exposed to cocaine and that such effects are independent of DA release...
  13. pmc Inhibition of PKMzeta in nucleus accumbens core abolishes long-term drug reward memory
    Yan qin Li
    National Institute on Drug Dependence, Peking University, Beijing 100191, China
    J Neurosci 31:5436-46. 2011
    ..used conditioned place preference (CPP) and conditioned place aversion (CPA) procedures to study the role of nucleus accumbens PKMζ in the maintenance of drug reward and aversion memories in rats...
  14. pmc Calcium-permeable AMPA receptors are present in nucleus accumbens synapses after prolonged withdrawal from cocaine self-administration but not experimenter-administered cocaine
    James E McCutcheon
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064, USA
    J Neurosci 31:5737-43. 2011
    ..which lead to behavioral sensitization, increase AMPA receptor (AMPAR) transmission in the rodent nucleus accumbens (NAc) in a withdrawal-dependent manner...
  15. pmc Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking
    Garret D Stuber
    Department of Psychiatry, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nature 475:377-80. 2011
    ..The BLA projection to the nucleus accumbens (NAc) is thought to modulate cue-triggered motivated behaviours, but our understanding of the interaction ..
  16. doi Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc
    Manuel Mameli
    Department of Basic Neurosciences, Medical Faculty, University of Geneva, Geneva, Switzerland
    Nat Neurosci 12:1036-41. 2009
    ..efficiently triggers NMDA receptor-dependent synaptic plasticity in DA neurons, whereas plasticity in the nucleus accumbens (NAc) occurs only after repeated injections...
  17. ncbi Functional magnetic resonance imaging of reward prediction
    Brian Knutson
    Psychology Department, Stanford University, Stanford, California 94305, USA
    Curr Opin Neurol 18:411-7. 2005
    ....
  18. pmc Antidepressant actions of histone deacetylase inhibitors
    Herbert E Covington
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Neurosci 29:11451-60. 2009
    ..causes a transient decrease, followed by a persistent increase, in levels of acetylated histone H3 in the nucleus accumbens, an important limbic brain region...
  19. ncbi The role of nucleus accumbens dopamine in motivated behavior: a unifying interpretation with special reference to reward-seeking
    S Ikemoto
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, Baltimore, MD 21224, USA
    Brain Res Brain Res Rev 31:6-41. 1999
    Studies addressing behavioral functions of dopamine (DA) in the nucleus accumbens septi (NAS) are reviewed. A role of NAS DA in reward has long been suggested...
  20. ncbi Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
    Gaetano Di Chiara
    Department of Toxicology, Center of Excellence for Studies on Dependence CESID and CNR Neuroscience Institute, University of Cagliari, Via Ospedale, 72 I 09124, Cagliari, Italy
    Behav Brain Res 137:75-114. 2002
    ..Drugs share with non-drug rewards the property of stimulating dopamine (DA) transmission in the nucleus accumbens shell but this effect does not undergo habituation upon repeated drug exposure, as instead is the case of ..
  21. doi Sertraline increases extracellular levels not only of serotonin, but also of dopamine in the nucleus accumbens and striatum of rats
    Yuji Kitaichi
    Department of Molecular Stressphysiology, Max Planck Institute of Psychiatry, Munich, Germany
    Eur J Pharmacol 647:90-6. 2010
    ..paroxetine on extracellular serotonin, dopamine, and noradrenaline levels in the medial prefrontal cortex, nucleus accumbens and striatum of rats using in vivo microdialysis...
  22. pmc Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens
    Brad A Grueter
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California, USA
    Nat Neurosci 13:1519-25. 2010
    Synaptic modifications in the nucleus accumbens (NAc) are important for adaptive and pathological reward-dependent learning...
  23. pmc Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake
    Amanda M Dossat
    Department of Psychology and Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4301, USA
    J Neurosci 31:14453-7. 2011
    ..One such region is the nucleus accumbens (NAc), which plays a role in reward and motivated behavior...
  24. pmc Individual differences in nucleus accumbens activity to food and sexual images predict weight gain and sexual behavior
    Kathryn E Demos
    Department of Psychological and Brain Sciences, Center for Cognitive Neuroscience, Dartmouth College, Hanover, New Hampshire 03755, USA
    J Neurosci 32:5549-52. 2012
    ..Here we show that individual differences in human reward-related brain activity in the nucleus accumbens to food and sexual images predict subsequent weight gain and sexual activity 6 months later...
  25. doi Induction of activating transcription factors (ATFs) ATF2, ATF3, and ATF4 in the nucleus accumbens and their regulation of emotional behavior
    Thomas A Green
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 28:2025-32. 2008
    Previous research has shown that cAMP response element (CRE) binding protein (CREB) in the nucleus accumbens gates behavioral responses to emotional stimuli...
  26. pmc A silent synapse-based mechanism for cocaine-induced locomotor sensitization
    Travis E Brown
    Washington State University, Pullman, Washington 99164 6520, USA
    J Neurosci 31:8163-74. 2011
    ..Here, we further analyzed the role of cocaine-induced silent synapses in the nucleus accumbens (NAc) shell and their contribution to the development of locomotor sensitization...
  27. pmc The general and outcome-specific forms of Pavlovian-instrumental transfer are differentially mediated by the nucleus accumbens core and shell
    Laura H Corbit
    School of Psychology, The University of Sydney, Sydney NSW 2006, Australia
    J Neurosci 31:11786-94. 2011
    ..Experiment 1) or muscimol-induced inactivation (Experiment 2) of either the core or shell regions of the nucleus accumbens (NAC) on these forms of PIT...
  28. ncbi A region of mesial prefrontal cortex tracks monetarily rewarding outcomes: characterization with rapid event-related fMRI
    Brian Knutson
    Department of Psychology, Building 420, Jordan Hall, Stanford University, Stanford, CA 94305 2130, USA
    Neuroimage 18:263-72. 2003
    ..00 win, MPFC activity decreased, relative to outcomes with no incentive value. These findings suggest that in the context of processing monetary rewards, a region of the MPFC preferentially tracks rewarding outcomes...
  29. pmc Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    Alfonso Abizaid
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    J Clin Invest 116:3229-39. 2006
    ..where it triggered increased dopamine neuronal activity, synapse formation, and dopamine turnover in the nucleus accumbens in a GHSR-dependent manner...
  30. ncbi Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli
    William Renthal
    Department of Psychiatry and Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9070, USA
    Neuron 56:517-29. 2007
    ..Chronic, but not acute, exposure to cocaine or stress decreases HDAC5 function in the nucleus accumbens (NAc), a major brain reward region, which allows for increased histone acetylation and transcription of ..
  31. ncbi The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment
    Ina Weiner
    Department of Psychology, Tel Aviv University, Tel Aviv, Israel
    Psychopharmacology (Berl) 169:257-97. 2003
    ..Consequently, disrupted LI is considered to provide an animal model of positive symptoms of schizophrenia with face, construct and predictive validity...
  32. ncbi Behavioral sensitization to cocaine is associated with increased AMPA receptor surface expression in the nucleus accumbens
    Amy C Boudreau
    Department of Neuroscience, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci 25:9144-51. 2005
    ..Cross-linking was used to distinguish between cell surface and intracellular AMPA receptors in nucleus accumbens (NAc) tissue obtained from rats treated repeatedly with saline or cocaine...
  33. pmc N-Acetylcysteine reverses cocaine-induced metaplasticity
    Khaled Moussawi
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue BSB410, Charleston, South Carolina, USA
    Nat Neurosci 12:182-9. 2009
    ..in vivo deficit in the ability to develop long-term potentiation (LTP) and long-term depression (LTD) in the nucleus accumbens core subregion after stimulation of the prefrontal cortex...
  34. pmc Essential role of the histone methyltransferase G9a in cocaine-induced plasticity
    Ian Maze
    Fishberg Department of Neuroscience, Mount Sinai School of Medicine, New York, NY, USA
    Science 327:213-6. 2010
    ..Repeated cocaine administration reduced global levels of H3K9 dimethylation in the nucleus accumbens. This reduction in histone methylation was mediated through the repression of G9a in this brain region, ..
  35. ncbi An essential role for DeltaFosB in the nucleus accumbens in morphine action
    Venetia Zachariou
    Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:205-11. 2006
    The transcription factor DeltaFosB is induced in the nucleus accumbens (NAc) and dorsal striatum by the repeated administration of drugs of abuse. Here, we investigated the role of DeltaFosB in the NAc in behavioral responses to opiates...
  36. pmc Cocaine regulates MEF2 to control synaptic and behavioral plasticity
    Suprabha Pulipparacharuvil
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9127, USA
    Neuron 59:621-33. 2008
    ..cocaine causes sensitized behavioral responses and increased dendritic spines on medium spiny neurons of the nucleus accumbens (NAc)...
  37. ncbi D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption
    K L Nowend
    Unit 1020, Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269-1020, USA
    Pharmacol Biochem Behav 69:373-82. 2001
    ..SCH 23390 or the D2 antagonist raclopride were injected into the either the core or shell subregions of nucleus accumbens, and rats were tested on the concurrent lever pressing/feeding task...
  38. pmc Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks
    Henry H Yin
    Department of Psychology and Neuroscience, Center for Cognitive Neuroscience, Duke University, Durham, NC 27708, USA
    Eur J Neurosci 28:1437-48. 2008
    ..mesoaccumbens pathway arising from dopaminergic neurons in the ventral tegmental area and projecting to the nucleus accumbens. This widely accepted view assumes that reward is a monolithic concept, but recent work has suggested ..
  39. pmc Reduced caudate and nucleus accumbens response to rewards in unmedicated individuals with major depressive disorder
    Diego A Pizzagalli
    Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland St, Cambridge, MA 02138, USA
    Am J Psychiatry 166:702-10. 2009
    ....
  40. pmc Mining Affymetrix microarray data for long non-coding RNAs: altered expression in the nucleus accumbens of heroin abusers
    Sharon K Michelhaugh
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Neurochem 116:459-66. 2011
    ..A previously published dataset derived from human nucleus accumbens was then examined for potential lncRNA expression...
  41. pmc Arousal effect of caffeine depends on adenosine A2A receptors in the shell of the nucleus accumbens
    Michael Lazarus
    Department of Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565 0874, Japan
    J Neurosci 31:10067-75. 2011
    ..adeno-associated virus carrying short-hairpin RNA, we report that the A(2A)Rs in the shell region of the nucleus accumbens (NAc) are responsible for the effect of caffeine on wakefulness...
  42. pmc Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior
    Jennifer L Warner-Schmidt
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10065, USA
    Proc Natl Acad Sci U S A 109:11360-5. 2012
    A large number of studies have demonstrated that the nucleus accumbens (NAC) is a critical site in the neuronal circuits controlling reward responses, motivation, and mood, but the neuronal cell type(s) underlying these processes are not ..
  43. ncbi Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates
    S Tanganelli
    Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy
    Peptides 22:1229-34. 2001
    ..for an antagonistic CCK(B)/D(2) receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum...
  44. ncbi The ventral tegmental area is required for the behavioral and nucleus accumbens neuronal firing responses to incentive cues
    Irene A Yun
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 24:2923-33. 2004
    ..Reward-seeking elicited by predictive cues is facilitated by the release of dopamine in the nucleus accumbens (NAc), yet the contribution of dopamine to the specific NAc firing patterns that underlie goal-directed ..
  45. ncbi Ghrelin administration into tegmental areas stimulates locomotor activity and increases extracellular concentration of dopamine in the nucleus accumbens
    Elisabet Jerlhag
    Institute of Neuroscience and Physiology, Department of Pharmacology, Goteborg University, Goteborg, Sweden
    Addict Biol 12:6-16. 2007
    ..to the mesolimbic dopamine system that originates in the ventral tegmental area (VTA) and projects to the nucleus accumbens. Given that growth hormone secretagogue receptors (GHSR-1A) are expressed in the VTA and LDTg, brain areas ..
  46. pmc Cell surface AMPA receptors in the rat nucleus accumbens increase during cocaine withdrawal but internalize after cocaine challenge in association with altered activation of mitogen-activated protein kinases
    Amy C Boudreau
    Department of Neuroscience, The Chicago Medical School at Rosalind Franklin University of Medicine and Science, North Chicago, Illinois 60064 3095, USA
    J Neurosci 27:10621-35. 2007
    Although some studies report increased responsiveness of nucleus accumbens (NAc) AMPA receptors (AMPARs) after withdrawal from repeated cocaine treatment, others report decreased responsiveness after withdrawal plus cocaine challenge...
  47. pmc In vivo cocaine experience generates silent synapses
    Yanhua H Huang
    Program in Neuroscience, Washington State University, Pullman, WA 99164 6520, USA
    Neuron 63:40-7. 2009
    ..that highly salient in vivo experience, such as exposure to cocaine, generates silent synapses in the nucleus accumbens (NAc) shell, a key brain region mediating addiction-related learning and memory...
  48. doi Nucleus accumbens medium spiny neurons target non-dopaminergic neurons in the ventral tegmental area
    Yanfang Xia
    Ernest Gallo Clinic and Research Center, Wheeler Center for Neurobiology of Addiction, and Department of Neurology, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 31:7811-6. 2011
    The midbrain ventral tegmental area (VTA) projection to the nucleus accumbens (NAc) is implicated in motivation and reinforcement...
  49. ncbi Differential control over cocaine-seeking behavior by nucleus accumbens core and shell
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB1 1BB, UK
    Nat Neurosci 7:389-97. 2004
    b>Nucleus accumbens (NAc) dopamine is widely implicated in mediating the reinforcing effects of drugs of abuse. However, the precise function of the NAc itself in drug self-administration has been difficult to establish...
  50. ncbi Neural and behavioral plasticity associated with the transition from controlled to escalated cocaine use
    Carrie R Ferrario
    Department of Psychology Biopsychology and Neuroscience Program, University of Michigan, Ann Arbor, MIichigan 48109 1109, USA
    Biol Psychiatry 58:751-9. 2005
    ..We asked here whether extended access to cocaine also produces drug-induced sensitization, a form of neurobehavioral plasticity implicated in addiction...
  51. pmc Nucleus accumbens μ-opioid receptors mediate social reward
    Viviana Trezza
    Rudolf Magnus Institute of Neuroscience, Department of Neuroscience and Pharmacology, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands
    J Neurosci 31:6362-70. 2011
    ..neural underpinnings of social reward by investigating the involvement of opioid neurotransmission in the nucleus accumbens (NAc) in social play behavior, a highly rewarding social interaction in adolescent rats...
  52. ncbi A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants
    R C Pierce
    Alcohol and Drug Abuse Program, Washington State University, Pullman 99164 6520, USA
    Brain Res Brain Res Rev 25:192-216. 1997
    ..of behavioral sensitization has progressed from a singular focus on dopamine transmission in the nucleus accumbens and striatum to the study of cellular and molecular mechanisms that occur throughout the neural circuitry in ..
  53. ncbi The neural basis of addiction: a pathology of motivation and choice
    Peter W Kalivas
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Ave, BSB 403, Charleston, SC 29425, USA
    Am J Psychiatry 162:1403-13. 2005
    ....
  54. doi Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, 53105 Bonn, Germany
    Biol Psychiatry 67:110-6. 2010
    ..Since anhedonia is a feature of depression and there is evidence of dysfunction of the reward system, DBS to the nucleus accumbens (NAcc) might be promising.
  55. ncbi Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons
    S B Floresco
    Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 21:4915-22. 2001
    ..As a result, dysfunctions in hippocampal circuitries may contribute to the hyperexcitable state of the DA system that is present in schizophrenia...
  56. ncbi Cocaine experience controls bidirectional synaptic plasticity in the nucleus accumbens
    Said Kourrich
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Neurosci 27:7921-8. 2007
    ..In animal models of addiction, glutamatergic signaling in the nucleus accumbens (NAc) exerts powerful control over drug-seeking behavior...
  57. ncbi Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression
    Christopher S Monk
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Am J Psychiatry 165:90-8. 2008
    ..This study compares amygdala and nucleus accumbens activation in children and adolescents at high and low risk for major depression under varying attentional ..
  58. pmc AMPA receptor plasticity in the nucleus accumbens after repeated exposure to cocaine
    Marina E Wolf
    Department of Neuroscience, Rosalind Franklin University of Medicine and Science, 3333 Green Bay Road, North Chicago, IL 60064 3095, United States
    Neurosci Biobehav Rev 35:185-211. 2010
    This review focuses on cocaine-induced postsynaptic plasticity in the nucleus accumbens (NAc) involving changes in AMPA receptor (AMPAR) transmission. First, fundamental properties of AMPAR in the NAc are reviewed...
  59. ncbi Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission
    Stan B Floresco
    Department of Neuroscienc, University of Pittsburgh, 446 Crawford Hall, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 6:968-73. 2003
    ....
  60. ncbi Corticostriatal-hypothalamic circuitry and food motivation: integration of energy, action and reward
    Ann E Kelley
    Department of Psychiatry, University of Wisconsin Madison Medical School, 6001 Research Park Blvd, Madison, WI 53719, USA
    Physiol Behav 86:773-95. 2005
    ..motivation are differentially mediated by separate but interacting neurochemical systems within the nucleus accumbens (Acb)...
  61. doi Transition to addiction is associated with a persistent impairment in synaptic plasticity
    Fernando Kasanetz
    INSERM U862, Neurocentre Magendie, 147 Rue Léo Saignat, 33077, Bordeaux Cedex, France
    Science 328:1709-12. 2010
    ..rapidly suppresses long-term depression (LTD), an important form of synaptic plasticity in the nucleus accumbens. Using a rat model of addiction, we found that animals that progressively develop the behavioral hallmarks ..
  62. pmc Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats
    Zachary A Rodd
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202 4887, United States
    Pharmacol Biochem Behav 89:481-98. 2008
    ..current study examined the effects of operant ethanol (EtOH) self-administration on gene expression kin the nucleus accumbens (ACB) and amygdala (AMYG) of inbred alcohol-preferring (iP) rats...
  63. pmc Glutamatergic signaling by mesolimbic dopamine neurons in the nucleus accumbens
    Fatuel Tecuapetla
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey 07102, USA
    J Neurosci 30:7105-10. 2010
    ..neurons in mice release glutamate and elicit excitatory postsynaptic responses in projection neurons of the nucleus accumbens. In addition, we describe the properties of the postsynaptic glutamatergic responses of these neurons during ..
  64. ncbi Dissociation of reward anticipation and outcome with event-related fMRI
    B Knutson
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, 20892-1610, USA
    Neuroreport 12:3683-7. 2001
    ..These findings suggest that reward anticipation and outcomes may differentially recruit distinct regions that lie along the trajectory of ascending dopamine projections...
  65. pmc The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: integration of resting EEG, fMRI, and volumetric techniques
    Jan Wacker
    Department of Psychology, Philipps Universitaet, Marburg, Germany
    Neuroimage 46:327-37. 2009
    ..We found that anhedonia, but not other symptoms of depression or anxiety, was correlated with reduced nucleus accumbens (NAcc) responses to rewards (gains in a monetary incentive delay task), reduced NAcc volume, and increased ..
  66. ncbi Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
    Yukiori Goto
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nat Neurosci 8:805-12. 2005
    Goal-directed behavior is believed to involve interactions of prefrontal cortical and limbic inputs in the nucleus accumbens (NAcc), and their modulation by mesolimbic dopamine (DA) seems to be of primary importance in NAcc function...
  67. ncbi Ghrelin stimulates locomotor activity and accumbal dopamine-overflow via central cholinergic systems in mice: implications for its involvement in brain reward
    Elisabet Jerlhag
    Institute of Pharmacology and Physiology, Department of Pharmacology, Goteborg University, Sweden
    Addict Biol 11:45-54. 2006
    ..to the third ventricle) induced an acute increase in locomotor activity as well as dopamine-overflow in the nucleus accumbens, suggesting that ghrelin can activate the mesoaccumbal dopamine system originating in the ventral tegmental ..
  68. ncbi Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi
    Kimberly A Badanich
    Department of Psychology, Cognitive and Neural Sciences, University of South Florida 4202 E Fowler Avenue Tampa, FL 33620, USA
    Eur J Pharmacol 550:95-106. 2006
    ..to differences in the mesolimbic dopaminergic system, we measured extracellular dopamine levels in the nucleus accumbens septi of PND 35, PND 45 and PND 60 rats via quantitative microdialysis under transient conditions...
  69. pmc Ventral pallidum roles in reward and motivation
    Kyle S Smith
    McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Behav Brain Res 196:155-67. 2009
    ..We conclude that the ventral pallidum may serve as an important 'limbic final common pathway' for mesocorticolimbic processing of many rewards...
  70. pmc Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core
    Nadia Chaudhri
    Ernest Gallo Clinic and Research Center, Department of Neurology, University of California at San Francisco, 5858 Horton Street Suite 200, Emeryville, CA 94608, USA
    Eur J Neurosci 28:2288-98. 2008
    ..We also determined whether pharmacologically inactivating the nucleus accumbens (NAc), a key structure in relapse circuitry, would attenuate reinstated EtOH-seeking...
  71. pmc Nucleus accumbens deep brain stimulation produces region-specific alterations in local field potential oscillations and evoked responses in vivo
    Clinton B McCracken
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 29:5354-63. 2009
    Deep brain stimulation of the nucleus accumbens (NAC) region is an effective therapeutic avenue for several psychiatric disorders that are not responsive to traditional treatment strategies...
  72. pmc Dissociable control of impulsivity in rats by dopamine d2/3 receptors in the core and shell subregions of the nucleus accumbens
    Morgane Besson
    Behavioral and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Cambridge, UK
    Neuropsychopharmacology 35:560-9. 2010
    Previous research has identified the nucleus accumbens (NAcb) as an important brain region underlying inter-individual variation in impulsive behavior...
  73. pmc Variability in nucleus accumbens activity mediates age-related suboptimal financial risk taking
    Gregory R Samanez-Larkin
    Department of Psychology, Stanford University, Stanford, California 94305 2130, USA
    J Neurosci 30:1426-34. 2010
    ..This age-related effect was mediated by a neural measure of temporal variability in nucleus accumbens activity. These findings reveal a novel neural mechanism by which aging may disrupt rational financial choice...
  74. pmc D-cycloserine reduces the context specificity of pavlovian extinction of cocaine cues through actions in the nucleus accumbens
    Mary M Torregrossa
    Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    J Neurosci 30:10526-33. 2010
    ..The effect of systemic DCS was recapitulated by administration of DCS into the nucleus accumbens core, but not in the basolateral amygdala, dorsal hippocampus, infralimbic or prelimbic prefrontal cortex...
  75. doi Ghrelin receptor antagonism attenuates nicotine-induced locomotor stimulation, accumbal dopamine release and conditioned place preference in mice
    Elisabet Jerlhag
    Section for Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Drug Alcohol Depend 117:126-31. 2011
    ..As the target circuits for other drugs of abuse, including nicotine, in the brain includes this reward link, we sought to determine whether the central ghrelin signalling system is involved in nicotine's activation of this system...
  76. pmc GLP-1 neurons in the nucleus of the solitary tract project directly to the ventral tegmental area and nucleus accumbens to control for food intake
    Amber L Alhadeff
    Department of Psychiatry, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Endocrinology 153:647-58. 2012
    ..g. the ventral tegmental area (VTA) and the nucleus accumbens (NAc)...
  77. pmc Neural circuit competition in cocaine-seeking: roles of the infralimbic cortex and nucleus accumbens shell
    Ryan T Lalumiere
    Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
    Eur J Neurosci 35:614-22. 2012
    ..Previous evidence suggests that the nucleus accumbens shell both promotes and suppresses cocaine-seeking...
  78. pmc Long-term effects of nucleus accumbens deep brain stimulation in treatment-resistant depression: evidence for sustained efficacy
    Bettina H Bewernick
    Department of Psychiatry and Psychotherapy, University Hospital, Bonn, Germany
    Neuropsychopharmacology 37:1975-85. 2012
    Deep brain stimulation (DBS) to the nucleus accumbens (NAcc-DBS) was associated with antidepressant, anxiolytic, and procognitive effects in a small sample of patients suffering from treatment-resistant depression (TRD), followed over 1 ..
  79. pmc Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
    David M Dietz
    Fishberg Department of Neuroscience and Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY, USA
    Nat Neurosci 15:891-6. 2012
    Repeated cocaine administration increases the dendritic arborization of nucleus accumbens neurons, but the underlying signaling events remain unknown...
  80. doi Nucleus accumbens response to food cues predicts subsequent snack consumption in women and increased body mass index in those with reduced self-control
    Natalia S Lawrence
    School of Psychology, Cardiff University, Park Place, Cardiff CF10 3AT, UK
    Neuroimage 63:415-22. 2012
    ..Using fMRI in healthy women, we found that food cue related activity in the nucleus accumbens, a key brain region for food motivation and reward, was related to subsequent snack food consumption...
  81. pmc Anhedonia requires MC4R-mediated synaptic adaptations in nucleus accumbens
    Byung Kook Lim
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA
    Nature 487:183-9. 2012
    ..that chronic stress in mice decreases the strength of excitatory synapses on D1 dopamine receptor-expressing nucleus accumbens medium spiny neurons owing to activation of the melanocortin 4 receptor...
  82. pmc Subsecond dopamine release in the nucleus accumbens predicts conditioned punishment and its successful avoidance
    Erik B Oleson
    Department of Anatomy and Neurobiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci 32:14804-8. 2012
    ..Here, we used fast-scan cyclic voltammetry to investigate whether subsecond dopamine release events in the nucleus accumbens encode cues predicting the avoidance of punishment during behavior maintained in a signaled footshock ..
  83. pmc Microinjections of acetaldehyde or salsolinol into the posterior ventral tegmental area increase dopamine release in the nucleus accumbens shell
    Gerald A Deehan
    Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Alcohol Clin Exp Res 37:722-9. 2013
    ..The current study was undertaken to examine the dose-response effects of microinjections of ACD or SAL into the pVTA on DA efflux in the nucleus accumbens shell (AcbSh).
  84. pmc Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use
    Roland Bock
    Laboratory for Integrative Neuroscience, National Institute of Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, Maryland, USA
    Nat Neurosci 16:632-8. 2013
    ..with synaptic plasticity in medium spiny neurons expressing dopamine D2 receptors (D2-MSNs) in the nucleus accumbens (NAc) of mice...
  85. pmc Genetic reconstruction of dopamine D1 receptor signaling in the nucleus accumbens facilitates natural and drug reward responses
    Bryan B Gore
    Department of Pharmacology and Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington 98053, USA
    J Neurosci 33:8640-9. 2013
    ..functional D1R signaling in D1R knock-out mice, we define distinct requirements of D1R in subregions of the nucleus accumbens (NAc) for specific dimensions of reward...
  86. pmc Amphetamine or cocaine limits the ability of later experience to promote structural plasticity in the neocortex and nucleus accumbens
    Bryan Kolb
    Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada T1K 3M4
    Proc Natl Acad Sci U S A 100:10523-8. 2003
    ..and the number of dendritic branches and the density of dendritic spines on medium spiny neurons in the nucleus accumbens and pyramidal cells in the parietal cortex were quantified...
  87. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
    ..However, it is unclear whether and how mGluR7 modulates nucleus accumbens (NAc) dopamine (DA), L-glutamate or gamma-aminobutyric acid (GABA), important neurotransmitters believed to ..
  88. ncbi D1 dopamine receptor stimulation increases the rate of AMPA receptor insertion onto the surface of cultured nucleus accumbens neurons through a pathway dependent on protein kinase A
    Simona Mangiavacchi
    Department of Neuroscience, The Chicago Medical School, North Chicago, Illinois 60064 3095, USA
    J Neurochem 88:1261-71. 2004
    ..Post-natal rat nucleus accumbens (NAc) cultures were used to study the role of protein kinase A (PKA) in D1 receptor regulation of the ..
  89. ncbi Alterations in the morphology of dendrites and dendritic spines in the nucleus accumbens and prefrontal cortex following repeated treatment with amphetamine or cocaine
    T E Robinson
    Department of Psychology and Neuroscience Program, The University of Michigan, Ann Arbor 48109, USA
    Eur J Neurosci 11:1598-604. 1999
    ..number of dendritic branches and the density of dendritic spines on medium spiny neurons in the shell of the nucleus accumbens, and on apical dendrites of layer V pyramidal cells in the prefrontal cortex...
  90. ncbi Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior
    P Di Ciano
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 21:9471-7. 2001
    ..and the ability to elicit automatic, Pavlovian approach responses that have been shown to be mediated by the nucleus accumbens. The present experiment investigated the effects of infusions of glutamatergic or dopaminergic receptor ..
  91. pmc Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: a functional magnetic resonance imaging study
    Sean P David
    Cancer Research United Kingdom General Practice Research Group, Department of Clinical Pharmacology, University of Oxford, Radcliffe Infirmary, UK
    Biol Psychiatry 58:488-94. 2005
    ..Converging evidence from several theories of the development of incentive-sensitization to smoking-related environmental stimuli suggests that the ventral striatum plays an important role in the processing of smoking-related cue reactivity...
  92. ncbi Effort-related functions of nucleus accumbens dopamine and associated forebrain circuits
    J D Salamone
    Division of Behavioral Neuroscience, Department of Psychology, University of Connecticut, Storrs, CT, 06269 1020, USA
    Psychopharmacology (Berl) 191:461-82. 2007
    ..that there are critical problems with the hypothesis that brain dopamine (DA) systems, particularly in the nucleus accumbens, directly mediate the rewarding or primary motivational characteristics of natural stimuli such as food...
  93. ncbi Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
    Jeremy J Day
    Department of Psychology, Davie Hall CB no 3270, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Nat Neurosci 10:1020-8. 2007
    ..Here, we sampled dopamine levels in the rat nucleus accumbens on a rapid (100 ms) timescale using electrochemical technology during a classical conditioning procedure...
  94. pmc Requirement of central ghrelin signaling for alcohol reward
    Elisabet Jerlhag
    Section for Pharmacology, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, SE 405 30 Gothenburg, Sweden
    Proc Natl Acad Sci U S A 106:11318-23. 2009
    ..Our data suggest that central ghrelin signaling constitutes a potential target for treatment of alcohol-related disorders...
  95. ncbi Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice
    M S Szczypka
    Howard Hughes Medical Institute and, Department of Biochemistry, Box 357370, University of Washington, Seattle, WA 98195, USA
    Neuron 30:819-28. 2001
    ..restores feeding on regular chow and nest-building behavior, whereas restoration of DA production in the nucleus accumbens restores exploratory behavior...
  96. ncbi Involvement of dopamine D1 and D2 receptors in the nucleus accumbens core and shell in inhibitory response control
    Tommy Pattij
    Department of Anatomy and Neurosciences, Research Institute Neurosciences Vrije Universiteit, Center for Neurogenomics and Cognitive Research, VU Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Psychopharmacology (Berl) 191:587-98. 2007
    Impaired inhibitory control over behavior is a key feature in various psychiatric disorders, and recent studies indicated an important role for dopamine D(1) and D(2) receptors and the nucleus accumbens (Acb) in this respect.
  97. pmc Predicting value of pain and analgesia: nucleus accumbens response to noxious stimuli changes in the presence of chronic pain
    Marwan N Baliki
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Neuron 66:149-60. 2010
    ..Pain perception and related cortical activation patterns were similar in the two groups. However, nucleus accumbens (NAc) activity differentiated the groups at a very high accuracy, exhibiting phasic and tonic responses with ..
  98. pmc Dopaminergic terminals in the nucleus accumbens but not the dorsal striatum corelease glutamate
    Garret D Stuber
    Ernest Gallo Clinic and Research Center, University of California, San Francisco, Emeryville, California 94608, USA
    J Neurosci 30:8229-33. 2010
    ..midbrain dopamine neurons to stimulate exocytosis specifically from dopaminergic terminals in both the nucleus accumbens (NAc) shell and dorsal striatum of brain slices from adult mice...
  99. ncbi The dopamine D1 receptor is a critical mediator for cocaine-induced gene expression
    Dongsheng Zhang
    Department of Cell Biology, Neurobiology and Anatomy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267, USA
    J Neurochem 82:1453-64. 2002
    ..we systematically compared the expression of the fos and Jun family immediate early genes in the nucleus accumbens and caudoputamen in D1 receptor mutant and wild-type control mice after acute and repeated cocaine exposure...
  100. ncbi The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance
    Dan Georgescu
    Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9070, USA
    J Neurosci 25:2933-40. 2005
    ..The rodent MCH receptor (MCH1R) is highly expressed in the nucleus accumbens shell (AcSh), a region that is important in the regulation of appetitive behavior...
  101. ncbi Morphine withdrawal-induced morphological changes in the nucleus accumbens
    Saturnino Spiga
    Department of Animal Biology and Ecology, University of Cagliari, Italy
    Eur J Neurosci 22:2332-40. 2005
    ..conditions we studied the effects of withdrawal on the morphology of MSN of the core and shell of the nucleus accumbens (Nacc)...

Research Grants85

  1. Nucleus Accumbens-Mediated Feeding: Output Pathways
    Thomas R Stratford; Fiscal Year: 2010
    ..body of evidence assembled over the past several years indicates persuasively that GABAergic circuits in the nucleus accumbens shell (AcbSh) play an important role in the control of food intake...
  2. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  3. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..We will examine the prefrontal cortex, the striatum, the nucleus accumbens and hippocampus, regions implicated in schizophrenia...
  4. Diane Lebesgue; Fiscal Year: 2014
    ..a GPCR, is specifically expressed in dopamine cells of the ventral tegmental area (VTA) that project to the nucleus accumbens prompted me to examine the possibility that this GPCR plays a role in the hormonal regulation of drug ..
  5. David P Gavin; Fiscal Year: 2016
    ..data indicate, by comparison to DBA mice, C57 mice have lower BDNF expression in the shell of the nucleus accumbens (NAc), as well as less BDNF IXa mRNA expression in the NAc as a whole...
  6. ROBERT MARK WIGHTMAN; Fiscal Year: 2016
    ..3. We will test the hypothesis that extracellular O2 in the nucleus accumbens core (NAc) fluctuates during reward based activity...
  7. JENNIFER ANNE RINKER; Fiscal Year: 2014
    ..and G9a-like protein (GLP), and consequently reducing methylation of histone H3 on lysine 9 (H3K9) in the nucleus accumbens (NAc)...
  8. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..by CB1 and D2 receptors in subregions of the striatum/BG in Gng7 knockout mice, including caudate-putamen, nucleus accumbens and globus pallidus, as well as other CB1 and D2 containing regions such as prefrontal cortex and ..
  9. Scott J Russo; Fiscal Year: 2016
    ..model of stress-related mood and anxiety disorders, we have observed an increase in NF?B activity in the nucleus accumbens (NAc), a key brain reward structure...
  10. ULTRASTRUCTURE OF MESOLIMBIC TRANSMITTER INTERACTIONS
    Virginia M Pickel; Fiscal Year: 2012
    ..The therapeutic sites include the prefrontal cortex (PFC), the nucleus accumbens (Acb) and other forebrain regions that receive dopamine input from mesolimbic dopaminergic neurons within ..
  11. Scott C Steffensen; Fiscal Year: 2016
    ..This system consists of dopamine neurons in the midbrain ventral tegmental area (VTA) that innervate the nucleus accumbens and other limbic structures. Dopamine neurotransmission is controlled by local-circuit GABA interneurons...
  12. Sex and Stress Mechanisms of Vulnerability to Addiction
    Rajita Sinha; Fiscal Year: 2011
    ..VTA CRF contributes to cocaine- induced changes in DA signaling and molecular neuroadaptations within the nucleus accumbens, prefrontal cortex and amygdala using in vivo microdialysis, Western blot analysis of downstream molecular ..
  13. Subhash C Pandey; Fiscal Year: 2016
    ..The extended amygdala, which includes central nucleus of amygdala (CeA), medial nucleus of amygdala (MeA), nucleus accumbens (NAc) shell, and bed nucleus of stria terminalis (BNST) circuitries, has been shown to be involved in the ..
  14. Margaret E Rice; Fiscal Year: 2016
    ..of insulin increase evoked extracellular dopamine (DA) concentration ([DA]o) in caudate/putamen (CPu) and nucleus accumbens (NAc). Notably, this response is enhanced in FR rats, but blunted in OB rats...
  15. Brain changes in tinnitus
    Josef P Rauschecker; Fiscal Year: 2010
    ..A likely candidate for such a structure is the paralimbic nucleus accumbens. This part of the ventral striatum has excitatory connections to the reticular thalamic nucleus (RTN), which ..
  16. KENNETH W GRASING; Fiscal Year: 2015
    ..by applicant): Background Reinforcing effects of cocaine arise through release of dopamine (DA) in the nucleus accumbens by neurons that project from the ventral tegmental area (VTA)...
  17. Novel Role for Sirtuin Signaling Mechanisms and Downstream Targets in Depression
    Deveroux Ferguson; Fiscal Year: 2013
    ..disorders by performing chromatin immunoprecipitation followed by genome-wide profiling (ChIP-seq) in nucleus accumbens (NAc) tissue from control and socially defeated stressed mice...
  18. John J Woodward; Fiscal Year: 2016
    ..the effects of toluene on dopamine neurons of the ventral tegmental area (VTA), medium spiny neurons of the nucleus accumbens (NAcc) and deep-layer pyramidal neurons of the prefrontal cortex (PFC)...
  19. Eric J Nestler; Fiscal Year: 2016
    ..of dopamine neurons in the ventral tegmental area (VTA) and their projection regions, in particular, the nucleus accumbens (NAc)...
  20. Yasmin L Hurd; Fiscal Year: 2016
    ..The goal of this proposal is to characterize the whole population of mRNAs in the nucleus accumbens (NAc) of F1 offspring from parents with a history of THC exposure by transcriptome sequencing, as well as to ..
  21. Ruth I Wood; Fiscal Year: 2016
    ..We will determine if testosterone is a permissive signal to enhance dopamine activity in the nucleus accumbens in response to sexual stimuli (Aim 2A)...
  22. Christopher L Cunningham; Fiscal Year: 2016
    ..Brain areas of interest include: ventral tegmental area, amygdala, nucleus accumbens, bed nucleus of the stria terminalis, anterior cingulate cortex and the CA1 region of hippocampus...
  23. Adolescent brains, nicotine and endogenous prototoxins
    Rae Nishi; Fiscal Year: 2010
    ..changes in arborization of eYFP- labeled dendrites in layer 5 as well as changes in eYFP-terminals in nucleus accumbens occur;to determine if correlative changes in cholinergic innervation or dopaminergic interaction with eYFP-..
  24. Hongxin Dong; Fiscal Year: 2014
    ..Our preliminary data shows lower levels of antipsychotic induced c-Fos expression in the nucleus accumbens of aged mice, as well decreased acetylation of histone H3 lysine residue 27 (H3K27) on the c-fos promoter...
  25. Tacrine Effects on Cocaine Self-Administration and Pharmacokinetic Measures
    KENNETH W GRASING; Fiscal Year: 2012
    ..by applicant): Reinforcing effects of cocaine are believed to arise through release of dopamine (DA) at the nucleus accumbens by neurons in the ventral tegmental area...
  26. CRF and Stress Modulation of Phasic Dopamine Release and Behavior
    MATTHEW J WANAT; Fiscal Year: 2013
    ..factor (CRF) acts in the VTA to affect motivated behavior and phasic dopamine release in the nucleus accumbens to reward-related stimuli for natural (Aim 1) and drug (Aim 2a) reinforcers...
  27. Richard B Silverman; Fiscal Year: 2016
    ..The neurochemical response to drugs of abuse is a sharp increase in dopamine levels in the nucleus accumbens, which activates the neurons responsible for pleasure and reward responses...
  28. Prenatal Cannabis Exposure and Epigenetic Mechanisms Underlying Vulnerability to
    CLAUDIA VARGAS MORRIS; Fiscal Year: 2013
    ..brain during the prenatal period and are expressed on neurons that control dopamine neurotransmission in the nucleus accumbens (NAc)...
  29. Molecular mechanisms of neural plasticity in drug addiction
    LAURA NICOLE SMITH; Fiscal Year: 2010
    ..Recently, it has been shown that chronic cocaine exposure regulates spine density in the nucleus accumbens, the brain's reward center, via cyclic-adenosine monophosphate (cAMP)-dependent inhibition of a ..
  30. Addiction-like behavior in models of mood disorders: role of CLOCK and NPAS2
    Colleen A McClung; Fiscal Year: 2013
    ..at high levels in the mesolimbic dopaminergic reward circuit between the ventral tegmental area (VTA) and nucleus accumbens (NAc). This entire reward circuit is under circadian control...
  31. Jiang Hong Ye; Fiscal Year: 2016
    ..leads to substantial decrements in VTA DA neuronal activities and extracellular levels of dopamine in the nucleus accumbens. It is believed that this dopamine hypofunction leads to a dysphoric state that drives drug seeking to ..
  32. Amphetamine-Induced Transcriptional Plasticity in Striatal GABAergic Interneurons
    ANNE ELIZABETH WEST; Fiscal Year: 2013
    ..reward circuit is comprised of dopaminergic neurons in the ventral tegmental area and their targets in the nucleus accumbens (NAc) and other associated limbic brain regions...
  33. Regulation of striatal cannabinoid CB1 receptors by DARPP32 and deltaFosB mediate
    Matthew F Lazenka; Fiscal Year: 2012
    ..In particular, brain regions like the nucleus accumbens (NAC) and caudate-putamen (CPU) that contribute to the reward and motivational properties of THC have ..
  34. Melanocortin Signaling in Depression
    Michael Lutter; Fiscal Year: 2013
    ..3. To determine if selective re-expression of melanocortin receptor 4 in the nucleus accumbens is sufficient to restore normal anxiety and depression responses in melanocortin receptor 4 null mice...
  35. Thomas A Wadden; Fiscal Year: 2014
    ..g., ventral-tegmental area and nucleus accumbens), and other limbic areas (e.g., orbitofrontal cortex, amygdala, insula, and cingulate cortex)...
  36. Matthew R Hayes; Fiscal Year: 2016
    ..g. ventral tegmental area (VTA) and nucleus accumbens (NAc)];[2] whether dopaminergic and glutamatergic mechanisms mediate the intake suppressive effects of GLP-..
  37. Harvey J Grill; Fiscal Year: 2016
    ..nuclei associated with food intake control and assess the functional contributions of these projections to nucleus accumbens by measuring neural activity and dopamine release triggered by cues- associated with food reward and to the ..
  38. ANNE ELIZABETH WEST; Fiscal Year: 2016
    ..cocaine exerts long-lasting effects on behavior by inducing the transcription of new gene products in the nucleus accumbens (NAc) that change the excitability and/or synaptic connectivity of NAc neurons...
  39. The Role of CLOCK in Ethanol-Related Behaviors
    Angela Renee Ozburn; Fiscal Year: 2012
    ..Important components of this circuitry include the caudate-putamen, nucleus accumbens, central nucleus of the amygdala, and the ventral tegmental area (VTA)...
  40. Barbara J Mason; Fiscal Year: 2016
    ..of opioid peptide systems and endocannabinoid systems in "reward circuits" in the frontal cortex, and nucleus accumbens (Specific Aim 1)...
  41. Role of Dopamine Transporter: HIV-1 Tat Protein and Nicotine Sensitization
    Jun Zhu; Fiscal Year: 2010
    ..The DA projection from the ventral tegmental area (VTA) to the nucleus accumbens (NAc) plays a critical role in NIC-mediated behaviors that may contribute to NIC craving in humans...
  42. Negative symptoms of schizophrenia: animal models
    Athina Markou; Fiscal Year: 2013
    ..in vivo microdialysis to measure monoamine, glutamate, and GABA levels in the prefrontal cortex and the nucleus accumbens. These brain sites are implicated in schizophrenia pathology and performance in the proposed cognitive tasks...
  43. John R Mantsch; Fiscal Year: 2014
    ..pathway involving dopamine (DA) neurons in the ventral tegmental area (VTA) that likely project to nucleus accumbens (NA)...
  44. Functional characterization of D3 dopamine receptor in Drd3-EGFP transgenic mice
    Eldo V Kuzhikandathil; Fiscal Year: 2010
    ..coupling of D3 receptors to ion channels at the single cell level in fluorescent cells isolated from the nucleus accumbens and substantia nigra brain regions of the Drd3- EGFP transgenic mice...
  45. Mechanisms of Altered Dopamine Signaling in Cocaine Addiction
    David W Self; Fiscal Year: 2012
    ..Dopamine D2 receptors in the nucleus accumbens (NAc) play a major role in precipitating relapse to cocaine-seeking behavior, and undergo a profound ..
  46. Henry A Lester; Fiscal Year: 2014
    ..Aim 1 studies selective upregulation in the ventral tegmental area-nucleus accumbens (VTA-NAcc) pathway, which accounts for some aspects of both tolerance and sensitization to the rewarding ..
  47. Deborah A Finn; Fiscal Year: 2014
    ..SHAC procedure was decreased by a metabotropic receptor subtype 5 (mGluR5) antagonist, and it upregulated nucleus accumbens (NAc) mGluR5-Homer2-phosphatidylinositol 3-kinase (PI3K) signaling...
  48. A Molecular Analysis of the Gateway Hypothesis in Mice
    Amir Levine; Fiscal Year: 2012
    ..gene-chip analysis to selected target regions to survey patterns of mRNA in the striatum, particularly the nucleus accumbens, and the amygdala...
  49. Laura J Sim-Selley; Fiscal Year: 2015
    ..characteristics of affective cannabinoid analgesia versus reward in selected brain regions such as the nucleus accumbens, a brain area implicated in reward and affective pain, through the use of well- established neurochemical ..
  50. NORA IRMA PERRONE-BIZZOZERO; Fiscal Year: 2016
    ..in forebrain neurons;2) determine the effects of viral-mediated gene transfer of miR- 495 and 3) HuD to the nucleus accumbens shell of rats using the following 3 models of motivation for cocaine: i) break point on a progressive ratio ..
  51. Larry J Young; Fiscal Year: 2016
    ..OT acts in the nucleus accumbens (NAcc) to promote alloparental nurturing and pair bonding between mates...
  52. William A Carlezon; Fiscal Year: 2016
    ..Its purpose is to understand how interactions of CREB and kappa-opioid receptor (KOR) systems in the nucleus accumbens shell (NAs) affect behavior in the context of mood and anxiety disorders...
  53. Gustatory Control of Sodium Appetite
    Ralph Norgren; Fiscal Year: 2012
    ..We use the release of dopamine (DA) in the nucleus accumbens as a forebrain index of reward...
  54. Molecular Regulation of GABA(A) Receptor Function in Amygdala
    Kerry J Ressler; Fiscal Year: 2010
    ..Given the role of amygdala GABAergic systems in modulating dopaminergic tone within the nucleus accumbens, amygdala GABAA regulation may have a more general role in addictive disorders...
  55. NEUROBIOLOGY OF NICOTINE REWARD AND WITHDRAWAL
    Athina Markou; Fiscal Year: 2011
    ..self-administration in rats, by administering mGluR5, NMDA or AMPA/kainate receptor antagonists into the nucleus accumbens shell, the ventral tegmental area, the central nucleus of the amygdala or the prefrontal cortex...
  56. The ability of the transcription factor CREB in the Nac to regulate mood
    Ronald S Duman; Fiscal Year: 2011
    Project 1 focuses on the ability of the transcription factor CREB in the NAc (nucleus accumbens) to regulate mood and motivational state...
  57. Neuroimaging in the Oklahoma Family Health Patterns Project
    William R Lovallo; Fiscal Year: 2013
    ..decision-making is examined using a delay discounting task examining functioning of the extended amygdala, nucleus accumbens, caudate, ventromedial prefrontal cortex, and ventral anterior cingulate gyrus...
  58. Charles Chavkin; Fiscal Year: 2016
    ..Evidence strongly supports a role for KOR-dependent inhibition of dopamine release in the nucleus Accumbens (NAc), however recent evidence further suggests that dynorphin activation of p38 MAPK in the serotonergic ..
  59. rAAV-GDNF to study mesolimbic control of body mass
    Ronald J Mandel; Fiscal Year: 2012
    ..the extent to which the mesolimbic dopamine (DA) projection from the ventral tegmental area (VTA) to the nucleus accumbens (nAcc) contributes to GDNF-over-expression induced weight loss...
  60. Edinger-Westphal Urocortin-1 Involvement in Binge Ethanol Intake and Reward
    William J Giardino; Fiscal Year: 2013
    ..focused on the mesolimbic dopamine pathway and brain structures such as the ventral tegmental area and nucleus accumbens, our laboratory has provided converging lines of evidence to support a role for the centrally-projecting ..
  61. Effects of nicotine and varenicline on ethanol behaviors
    Noah R Gubner; Fiscal Year: 2013
    ..demonstrated that nicotine and ethanol can interact to cause synergist enhancement of dopamine levels in the nucleus accumbens (NACC), indicating that nicotine may enhance the rewarding effects of ethanol and contribute to the ..
  62. Galanin-opiate interactions
    Marina R Picciotto; Fiscal Year: 2012
    ..kinase (ERK) in the ventral tegmental area (VTA) and downstream target regions including the nucleus accumbens (NAc) and amygdala...
  63. Novel Mechanisms Underlying Depression: PET Imaging of the Kappa Opioid Receptor
    Jeffrey M Miller; Fiscal Year: 2012
    ..KOR stimulation may exert effects on mood through modulating dopamine release in the nucleus accumbens, a brain region central to processing reward which is implicated in the pathophysiology of depression, and ..
  64. Prenatal ethanol exposure effects on reward circuitry and ethanol consumption
    JAMES PATRICK RICE; Fiscal Year: 2012
    ..Although the effects of fetal ethanol exposure have been previously described in various brain regions, the nucleus accumbens and basal forebrain have not been systematically studied in moderate exposure paradigms...
  65. NUCLEUS ACCUMBENS INVOLVEMENT IN COCAINE REINFORCEMENT
    GREGORY MARK; Fiscal Year: 2002
    ..Research in this area has concentrated on the nucleus accumbens (NAc) which is considered to be an integral component in the link between motivation and action...
  66. A Controlled Trial of NAC for Cocaine Dependence
    Robert Malcolm; Fiscal Year: 2009
    ..Pre-clinical studies have elucidated the importance of glutaminergic and dopaminergic circuits among the nucleus accumbens, ventral tegmental area, and prefrontal cortex...
  67. N-Acetyl Cysteine plus Behavioral Therapy for Nicotine Dependent Pathological Gam
    Jon E Grant; Fiscal Year: 2010
    ..Preclinical studies have suggested that levels of glutamate within the nucleus accumbens mediate reward-seeking behavior and may underlie relapse seen in addictions...
  68. Role of AMPA receptors in the nucleus accumbens shell in morphine depedence
    Elena Chartoff; Fiscal Year: 2009
    ..purpose of this R03 proposal is to investigate how synaptic plasticity of AMPA glutamate receptors in the nucleus accumbens shell (NASh) mediates morphine dependence...
  69. NEUROPHARMACOLOGY OF ETHANOL REINFORCEMENT
    George Koob; Fiscal Year: 2002
    ..Work in the previous funding period was directed at examining the role of a limbic-nucleus accumbens-extrapyramidal circuit in ethanol reinforcement...
  70. Hippocampal-Prefrontal Control of Working Memory: Inactivation and PET in Monkeys
    MARIA ALVARADO; Fiscal Year: 2009
    ..modulation of dorsolateral PFC function occurs via the meso-limbic dopamine system (a circuit including the nucleus accumbens, ventral pallidum and ventral tegmental area (VTA))...
  71. DOPAMINE/GLUTAMATE INTERACTIONS IN NUCLEUS ACCUMBENS
    MARINA WOLF; Fiscal Year: 2001
    ..These include alterations in AMPA receptor expression and responsiveness in the nucleus accumbens (Nac), a brain region critical for the rewarding and addictive properties of psychostimulants...
  72. ROLE OF NUCLEUS ACCUMBENS CA2+ FLUX IN COCAINE REWARD
    WILLIAM CARLEZON; Fiscal Year: 2000
    ..Abstract) The purpose of this B/START proposal is to test the hypothesis that calcium (Ca2+) flux in the nucleus accumbens shell (NASh) influences the rewarding and aversive effects of cocaine in rats...
  73. The Functional Neurobiology of Cannabinoids in Brain
    EDWARD FRENCH; Fiscal Year: 2006
    ..activation causes a pronounced inhibition of GABAergic synaptic transmission in both the hippocampus and the nucleus accumbens. These effects in the hippocampus may be at least partly responsible for the well-known disruption of short-..
  74. The Functional Neurobiology of Cannabinoids in Brain
    EDWARD FRENCH; Fiscal Year: 2001
    ..activation causes a pronounced inhibition of GABAergic synaptic transmission in both the hippocampus and the nucleus accumbens. These effects in the hippocampus may be at least partly responsible for the well-known disruption of short-..
  75. PSYCHOSTIMULANT ACTION AT MESOACCUMBENS SYNAPSES
    Stephen Rayport; Fiscal Year: 1999
    ..lines of research have shown that psychostimulants act by dramatically increasing dopamine levels in the nucleus accumbens. This is due to action at the presynaptic terminals of ventral tegmental area dopamine neurons...
  76. Striatal Glutamate Homeostasis and Cocaine Relapse
    Lori Knackstedt; Fiscal Year: 2009
    ..cocaine-seeking in the animal model of reinstatement is associated with altered glutamate homeostasis in the nucleus accumbens core...
  77. Mesolimbic Dopamine Modulation of Cue-Enhanced Ventral Pallidal Activity
    Jennifer Taylor; Fiscal Year: 2009
    ..release from mesolimbic neurons originating in the ventral tegmental area, which in turn would activate the nucleus accumbens to ventral pallidum reward circuit...
  78. Amphetamine sensitization in a model of schizophrenia
    Russell W Brown; Fiscal Year: 2010
    This proposal is designed to analyze the effects of amphetamine sensitization on dopamine release in the nucleus accumbens in a rodent model of schizophrenia...
  79. ROLE OF DOPAMINE IN MDMA-INDUCED SEROTONIN DEPLETION
    J Nash; Fiscal Year: 1991
    ..5-HT and their metabolites will be accomplished by inserting a dialysis probe into either the striatum or nucleus accumbens and collecting perfusates at set time intervals (30 min over a 4 hr time period)...
  80. Differential Expression and Regulatory Functions of Long Non-Coding RNA Molecules
    Leonard Lipovich; Fiscal Year: 2009
    ..Its pathobiology has therefore been under intense study. The nucleus accumbens (NAc) is a brain region that plays a key role in normal reward learning and in addiction...