caudate nucleus

Summary

Summary: Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.

Top Publications

  1. ncbi Functional connectivity of human striatum: a resting state FMRI study
    A Di Martino
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 18:2735-47. 2008
  2. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
  3. ncbi Prevalence of serum antibodies to caudate nucleus in autistic children
    Vijendra K Singh
    Department of Biology, Biotechnology Center Building, Utah State University, 4700 Old Main Hill, Logan, UT 84322 4700, USA
    Neurosci Lett 355:53-6. 2004
  4. ncbi The well-worn route and the path less traveled: distinct neural bases of route following and wayfinding in humans
    Tom Hartley
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, University College London, London, United Kingdom
    Neuron 37:877-88. 2003
  5. ncbi Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus
    Robyn Bluhm
    Department of Psychiatry, University of Western Ontario, Ontario N6A 3H8, Canada
    Psychiatry Clin Neurosci 63:754-61. 2009
  6. ncbi Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice
    Giuseppe Iaria
    Douglas Hospital Research Center, McGill University, Verdun, Quebec, Canada, H4H 1R3
    J Neurosci 23:5945-52. 2003
  7. ncbi Caudate nucleus volume asymmetry predicts attention-deficit hyperactivity disorder (ADHD) symptomatology in children
    Gregory W Schrimsher
    Department of Psychology, University of Houston, Houston, TX, USA
    J Child Neurol 17:877-84. 2002
  8. pmc The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
    Harrison Banner
    Department of Psychiatry, Faculty of Medicine, McGill University, Douglas Mental Health University Institute, FBC Building, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Eur J Neurosci 33:968-77. 2011
  9. ncbi The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar
    Hans Otto Karnath
    Department of Cognitive Neurology, University of Tubingen, Tubingen, Germany
    Brain 125:350-60. 2002
  10. ncbi Some highlights of research on the effects of caudate nucleus lesions over the past 200 years
    Norman M White
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, QC H3A 1B1, Canada
    Behav Brain Res 199:3-23. 2009

Detail Information

Publications266 found, 100 shown here

  1. ncbi Functional connectivity of human striatum: a resting state FMRI study
    A Di Martino
    Phyllis Green and Randolph Cowen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA
    Cereb Cortex 18:2735-47. 2008
    ..This approach holds promise for studying basal ganglia dysfunction in clinical disorders...
  2. ncbi Dissociable roles of ventral and dorsal striatum in instrumental conditioning
    John O'Doherty
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK
    Science 304:452-4. 2004
    ..Our results suggest partly dissociable contributions of the ventral and dorsal striatum, with the former corresponding to the critic and the latter corresponding to the actor...
  3. ncbi Prevalence of serum antibodies to caudate nucleus in autistic children
    Vijendra K Singh
    Department of Biology, Biotechnology Center Building, Utah State University, 4700 Old Main Hill, Logan, UT 84322 4700, USA
    Neurosci Lett 355:53-6. 2004
    Autism may involve autoimmunity to brain. We studied regional distribution of antibodies to rat caudate nucleus, cerebral cortex, cerebellum, brain stem and hippocampus. The study included 30 normal and 68 autistic children...
  4. ncbi The well-worn route and the path less traveled: distinct neural bases of route following and wayfinding in humans
    Tom Hartley
    Institute of Cognitive Neuroscience and Department of Anatomy and Developmental Biology, University College London, University College London, London, United Kingdom
    Neuron 37:877-88. 2003
    ..We argue that the type of representation used influences both performance and concomitant fMRI activation patterns...
  5. ncbi Resting state default-mode network connectivity in early depression using a seed region-of-interest analysis: decreased connectivity with caudate nucleus
    Robyn Bluhm
    Department of Psychiatry, University of Western Ontario, Ontario N6A 3H8, Canada
    Psychiatry Clin Neurosci 63:754-61. 2009
    ..The objective of the present study was, therefore, to investigate the DMN in patients seeking help from specialized mental health services for the first time for symptoms of depression...
  6. ncbi Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice
    Giuseppe Iaria
    Douglas Hospital Research Center, McGill University, Verdun, Quebec, Canada, H4H 1R3
    J Neurosci 23:5945-52. 2003
    ..The other half used a nonspatial strategy and showed, with practice, sustained increased activity within the caudate nucleus during navigation. Activation common to both groups was observed in the posterior parietal and frontal cortex...
  7. ncbi Caudate nucleus volume asymmetry predicts attention-deficit hyperactivity disorder (ADHD) symptomatology in children
    Gregory W Schrimsher
    Department of Psychology, University of Houston, Houston, TX, USA
    J Child Neurol 17:877-84. 2002
    ..The results support the view that clinical ADHD is the extreme of a behavioral continuum that extends into the normal population...
  8. pmc The brain-derived neurotrophic factor Val66Met polymorphism is associated with reduced functional magnetic resonance imaging activity in the hippocampus and increased use of caudate nucleus-dependent strategies in a human virtual navigation task
    Harrison Banner
    Department of Psychiatry, Faculty of Medicine, McGill University, Douglas Mental Health University Institute, FBC Building, 6875 Boul LaSalle, Verdun, QC H4H 1R3, Canada
    Eur J Neurosci 33:968-77. 2011
    ..response' learning, which requires the memorization of a series of actions and is mediated by the caudate nucleus. Studies have demonstrated that people spontaneously use one of these two alternative navigational strategies ..
  9. ncbi The subcortical anatomy of human spatial neglect: putamen, caudate nucleus and pulvinar
    Hans Otto Karnath
    Department of Cognitive Neurology, University of Tubingen, Tubingen, Germany
    Brain 125:350-60. 2002
    ..Analysis revealed that the putamen, the pulvinar and, to a smaller degree, the caudate nucleus are the subcortical structures typically associated with spatial neglect in humans...
  10. ncbi Some highlights of research on the effects of caudate nucleus lesions over the past 200 years
    Norman M White
    Department of Psychology, McGill University, 1205 Dr Penfield Avenue, Montreal, QC H3A 1B1, Canada
    Behav Brain Res 199:3-23. 2009
    This review describes experiments on the effects of caudate nucleus lesions on behavior in monkeys, cats and rats...
  11. ncbi Different neural correlates of reward expectation and reward expectation error in the putamen and caudate nucleus during stimulus-action-reward association learning
    Masahiko Haruno
    Department of Cognitive Neuroscience Computational Neuroscience Labs, Advanced Telecommunication Research Institute, Sorakugun, Kyoto 619 0288, Japan
    J Neurophysiol 95:948-59. 2006
    ..However, the putamen and caudate nucleus are embedded in distinct cortico-striatal loop circuits, predominantly connected to motor-related cerebral ..
  12. ncbi Gray matter differences correlate with spontaneous strategies in a human virtual navigation task
    Veronique D Bohbot
    Department of Psychiatry, McGill University, Verdun, Quebec, Canada H4H 1R3
    J Neurosci 27:10078-83. 2007
    ..increased activity in the hippocampus, whereas response strategies were associated with activity in the caudate nucleus. Here, voxel based morphometry was used to identify brain regions covarying with the navigational strategies ..
  13. ncbi Role of dopamine in the primate caudate nucleus in reward modulation of saccades
    Kae Nakamura
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurosci 26:5360-9. 2006
    ..These results suggest that reward-dependent changes in saccadic eye movements depend partly on dopaminergic modulation of neuronal activity in the caudate nucleus.
  14. ncbi Electrophysiological effects and clinical results of direct brain stimulation for intractable epilepsy
    Sozari A Chkhenkeli
    Center of Functional Neurosurgery, Institute of Medical Bionics, Bratislava, Slovak Republic
    Clin Neurol Neurosurg 106:318-29. 2004
    ..Therefore, the artificial enhancement of the activity of brain inhibitory mechanisms might lead to a beneficial therapeutic effect for intractable epilepsy patients...
  15. ncbi In vivo electrophysiological characterization of 5-HT receptors in the guinea pig head of caudate nucleus and orbitofrontal cortex
    M el Mansari
    Neurobiological Psychiatry Unit, McGill University, Montreal, Quebec, Canada
    Neuropharmacology 36:577-88. 1997
    ..5-HT receptor subtypes which mediate the effect of microiontophoretic applied 5-HT in the guinea pig head of caudate nucleus and orbitofrontal cortex...
  16. ncbi Psychomotor slowing in older patients with major depression: Relationships with blood flow in the caudate nucleus and white matter lesions
    Ian B Hickie
    Brain and Mind Research Institute, University of Sydney, Sydney, Australia
    Psychiatry Res 155:211-20. 2007
    ..White matter lesions (WMLs) were visually rated and caudate nucleus regional cerebral blood flow (rCBF) was obtained through the co-registration of MRI and SPECT data...
  17. ncbi Encoding of social state information by neuronal activities in the macaque caudate nucleus
    Gustavo S Santos
    Laboratory for Integrated Theoretical Neuroscience, RIKEN BSI, Wako, Japan
    Soc Neurosci 7:42-58. 2012
    ..The neural mechanisms underlying this evaluation remain elusive. The caudate nucleus (CN) plays a pivotal role in representing reward expectation and translating it into action selection...
  18. ncbi Caudate nucleus is enlarged in high-functioning medication-naive subjects with autism
    Marieke Langen
    Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Biol Psychiatry 62:262-6. 2007
    ..Earlier studies investigating basal ganglia in autism have included subjects on neuroleptics known to affect basal ganglia volumes. Therefore, we investigated these structures in medication-naive subjects with autism...
  19. ncbi Getting to know you: reputation and trust in a two-person economic exchange
    Brooks King-Casas
    Human Neuroimaging Laboratory, Department of Neuroscience, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Science 308:78-83. 2005
    ..These data extend previous model-based functional magnetic resonance imaging studies into the social domain and broaden our view of the spectrum of functions implemented by the dorsal striatum...
  20. pmc Caudate nuclei volume, diffusion tensor metrics, and T(2) relaxation in healthy adults and relapsing-remitting multiple sclerosis patients: implications for understanding gray matter degeneration
    Khader M Hasan
    Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Magn Reson Imaging 29:70-7. 2009
    ..To investigate the utility of caudate nuclei (CN) macro- and microstructural metrics as markers of gray matter degeneration in healthy adults and relapsing-remitting multiple sclerosis (RRMS) patients...
  21. pmc Dopamine, but not serotonin, regulates reversal learning in the marmoset caudate nucleus
    Hannah F Clarke
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 31:4290-7. 2011
    ..to the OFC and extends subcortically to other structures implicated in reversal learning, such as the medial caudate nucleus. Therefore, because the roles of the serotonin and dopamine within the caudate nucleus are poorly understood, ..
  22. ncbi Parallel memory systems for talking about location and age in precuneus, caudate and Broca's region
    Mikkel Wallentin
    Center for Functionally Integrative Neuroscience, Aarhus University Hospital, Nørrebrogade, 8000 Aarhus C, Denmark
    Neuroimage 32:1850-64. 2006
    ..These findings indicate that multiple parallel memory systems are available during language processing, appropriate for different tasks, with performance reflecting which system is selected trial-by-trial and subject-by-subject...
  23. pmc Emotion processing influences working memory circuits in pediatric bipolar disorder and attention-deficit/hyperactivity disorder
    Alessandra M Passarotti
    Institute for Juvenile Research and Center for Cognitive Medicine, University of Illinois at Chicago, Chicago, IL 60608, USA
    J Am Acad Child Adolesc Psychiatry 49:1064-80. 2010
    ..This functional magnetic resonance imaging (fMRI) study examined how working memory circuits are affected by face emotion processing in pediatric bipolar disorder (PBD) and attention-deficit/hyperactivity disorder (ADHD)...
  24. pmc Clinical correlations of grey matter reductions in the caudate nucleus of adults with attention deficit hyperactivity disorder
    Luis Guillermo Almeida Montes
    Departamento de Investigación del Centro Estatal de Salud Mental, Queretaro, Mexico
    J Psychiatry Neurosci 35:238-46. 2010
    ..We sought to compare the volume of the caudate of adults with ADHD with that of healthy controls; we also compared these volumes between men and women...
  25. ncbi Differential roles of caudate nucleus and putamen during instrumental learning
    Andrea Brovelli
    Institut de Neurosciences Cognitives de la Mediterranee, UMR 6193, CNRS and Université Aix Marseille II, Marseille, France
    Neuroimage 57:1580-90. 2011
    ..The anterior caudate nucleus integrates information about performance and cognitive control demands, whereas the putamen tracks how likely ..
  26. ncbi The role of the striatum and hippocampus in planning: a PET activation study in Parkinson's disease
    A Dagher
    MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Brain 124:1020-32. 2001
    ..In the two groups, overlapping areas of the PFC were activated but, whereas the right caudate nucleus was activated in the control group, this was not evident in the Parkinson's disease patients...
  27. ncbi Acute caudate vascular lesions
    E Kumral
    Division of Cerebrovascular and Neuropsychology Unit, Department of Neurology, Faculty of Medicine, Ege University, Izmir, Turkey
    Stroke 30:100-8. 1999
    We sought to evaluate demographic features, risk factors, clinical profiles, and behavioral abnormalities in patients with caudate lesion, either with infarct or with hemorrhage involving the caudate nucleus.
  28. ncbi Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression. Case report
    Bruno Aouizerate
    Services de Psychiatrie A and B, Centre Hospitalier Charles Perrens, Bordeaux, France
    J Neurosurg 101:682-6. 2004
    ..In the present study, the authors tested the hypothesis that DBS of the ventral caudate nucleus might be effective in a patient with intractable severe OCD and concomitant major depression...
  29. ncbi Images of desire: food-craving activation during fMRI
    Marcia Levin Pelchat
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    Neuroimage 23:1486-93. 2004
    ..Craving-related changes in fMRI signal were identified in the hippocampus, insula, and caudate, three areas reported to be involved in drug craving. Thus, this work supports the common substrate hypothesis for food and drug cravings...
  30. ncbi Structural asymmetries in the human brain: a voxel-based statistical analysis of 142 MRI scans
    K E Watkins
    Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Cereb Cortex 11:868-77. 2001
    ..We also found previously described asymmetries in the cingulate sulcus (right > left) and the caudate nucleus (right > left)...
  31. ncbi Corticosteroids operate as a switch between memory systems
    Lars Schwabe
    University of Trier, Germany
    J Cogn Neurosci 22:1362-72. 2010
    ....
  32. ncbi Neurogenesis in the caudate nucleus of the adult rabbit
    Federico Luzzati
    Department of Animal and Human Biology, University of Turin, 10123 Turin, Italy
    J Neurosci 26:609-21. 2006
    ..reconstructions, and in vitro tissue cultures, we demonstrate the existence of newly formed neurons in the caudate nucleus of normal, untreated, adult rabbit...
  33. ncbi A neuropsychological theory of multiple systems in category learning
    F G Ashby
    Department of Psychology, University of California, Santa Barbara 93106, USA
    Psychol Rev 105:442-81. 1998
    ..e., procedural-learning-based) categorization systems. The theory assumes that the caudate nucleus is an important component of the implicit system and that the anterior cingulate and prefrontal cortices are ..
  34. ncbi Anticipation of increasing monetary reward selectively recruits nucleus accumbens
    B Knutson
    National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, Maryland 20892 1610, USA
    J Neurosci 21:RC159. 2001
    ..These findings suggest that whereas other striatal areas may code for expected incentive magnitude, a region in the NAcc codes for expected positive incentive value...
  35. ncbi The roles of the caudate nucleus in human classification learning
    Carol A Seger
    Department of Psychology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 25:2941-51. 2005
    The caudate nucleus is commonly active when learning relationships between stimuli and responses or categories...
  36. ncbi Onset and rate of striatal atrophy in preclinical Huntington disease
    E H Aylward
    Department of Radiology, University of Washington, Seattle, WA 98195, USA
    Neurology 63:66-72. 2004
    ..Huntington disease (HD) is characterized by striatal atrophy that begins long before the onset of motor symptoms...
  37. pmc Neural substrates of increased memory sensitivity for negative stimuli in major depression
    J Paul Hamilton
    Stanford University, Stanford, California 94305, USA
    Biol Psychiatry 63:1155-62. 2008
    ....
  38. ncbi Decreased diffusivity in the caudate nucleus of presymptomatic huntington disease gene carriers: which explanation?
    M L Mandelli
    Neuroradiology Department, Fondazione Istituto Nazionale Neurologico Carlo Besta, Milan, Italy
    AJNR Am J Neuroradiol 31:706-10. 2010
    ..The neostriatum is known to be affected in HD. In this work, our aim was to determine whether microstructural and volumetric alterations occur in the neostriatum of presymptomatic HD gene carriers and in patients with early-stage HD...
  39. ncbi An event-related functional MRI study comparing interference effects in the Simon and Stroop tasks
    Bradley S Peterson
    The Division of Child and Adolescent Psychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Brain Res Cogn Brain Res 13:427-40. 2002
    ..Therefore, despite the widely differing stimulus characteristics employed by these tasks, the neural systems that subserve successful task performance are likely to be similar as well...
  40. ncbi The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse
    Valentina Vengeliene
    Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany
    FASEB J 20:2223-33. 2006
    ..We therefore suggest that selective antagonists of this pharmacological target provide a specific treatment approach to reduce alcohol craving and relapse behavior...
  41. ncbi Effect of pre-ischaemic conditioning on hypoxic depolarization of dopamine efflux in the rat caudate brain slice measured in real-time with fast cyclic voltammetry
    Colin Davidson
    Division of Biomedical Science, St George s, University of London, London SW17 0RE, United Kingdom
    Neurochem Int 59:714-21. 2011
    ..These data suggest that 10 min OGD pre-ischaemic conditioning can evoke tolerance to a second OGD event and that voltammetric recording of OGD-evoked dopamine efflux is a useful model of pre-ischaemic conditioning in neuronal tissue...
  42. ncbi Patients with obsessive-compulsive disorder have increased 5-HT2A receptor binding in the caudate nuclei
    Karen H Adams
    Neurobiology Research Unit NRU, University Hospital of Copenhagen, Denmark
    Int J Neuropsychopharmacol 8:391-401. 2005
    ..The up-regulation in 5-HT(2A) receptors might be compensatory for a lack of serotonin in the feedback loop between the thalamus and orbito-frontal cortex, the caudate nuclei, and the globus pallidus...
  43. ncbi Effects of acute nicotine on hemodynamics and binding of [11C]raclopride to dopamine D2,3 receptors in pig brain
    Paul Cumming
    PET Center, Arhus Kommunehospital, Nørrebrogade 44, Arhus, Denmark
    Neuroimage 19:1127-36. 2003
    ..Evidently, nicotine challenge enhances the competition between endogenous dopamine for [(11)C]raclopride binding sites with a complex temporal and spacial pattern in pig brain, initially presenting in the left ventral striatum...
  44. ncbi Caudate nucleus volume in individuals at ultra-high risk of psychosis: a cross-sectional magnetic resonance imaging study
    Katrina L Hannan
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Parkville, Victoria, Australia
    Psychiatry Res 182:223-30. 2010
    ..Future research should examine changes longitudinally together with analysis of shape to assess subregions of the caudate that connect with prefrontal cortex...
  45. ncbi Caudate nucleus-dependent response strategies in a virtual navigation task are associated with lower basal cortisol and impaired episodic memory
    Veronique D Bohbot
    Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Verdun, Quebec, Canada
    Neurobiol Learn Mem 96:173-80. 2011
    ..either use a hippocampal-dependent spatial strategy by building relationships between landmarks, or a caudate nucleus-dependent stimulus-response strategy by automatizing a pattern of open and closed arms to learn the location ..
  46. ncbi Neural activity in primate caudate nucleus associated with pro- and antisaccades
    Kristen A Ford
    Graduate Program in Neuroscience, University of Western Ontario, London, Ontario N6A 5K8, Canada
    J Neurophysiol 102:2334-41. 2009
    ..stimulus must be inhibited in favor of a saccade to the opposite location, to investigate the role of the caudate nucleus, a major input structure of the BG, in flexible behavior...
  47. ncbi Neural substrates of visual paired associates in young adults with a history of very preterm birth: alterations in fronto-parieto-occipital networks and caudate nucleus
    Ana Narberhaus
    Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain
    Neuroimage 47:1884-93. 2009
    ..during encoding, VPT-born individuals showed increased BOLD signal response compared to controls in left caudate nucleus, right cuneus (BA 18) and left superior parietal lobule (BA 7), and decreased signal in right inferior ..
  48. ncbi Effects of locus coeruleus lesions on the release of endogenous dopamine in the rat nucleus accumbens and caudate nucleus as determined by intracerebral microdialysis
    A J Lategan
    Neurobiology Division, FONDAX Groupe de Recherche SERVIER, Puteaux, France
    Brain Res 523:134-8. 1990
    ..norepinephrine levels by 67%, (b) reduced the basal release of dopamine in the nucleus accumbens and caudate nucleus by 26% and 19%, respectively, and (c) reduced (+)-amphetamine-induced release in the nucleus accumbens and ..
  49. ncbi Neurosteroid biosynthetic pathway changes in substantia nigra and caudate nucleus in Parkinson's disease
    Sabina Luchetti
    Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Brain Pathol 20:945-51. 2010
    ..We have carried out an extensive study of the neurosteroid biosynthetic pathways in substantia nigra (SN), caudate nucleus (CN) and putamen (PU) of 7 Parkinson's disease (PD) patients and 7 matched controls...
  50. ncbi Characterization of Ngef, a novel member of the Dbl family of genes expressed predominantly in the caudate nucleus
    N R Rodrigues
    Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford, OX1 3QX, United Kingdom
    Genomics 65:53-61. 2000
    ..Ngef is predominantly expressed in brain, with the strongest signal in the caudate nucleus, a region associated with the control of movement...
  51. ncbi Pursuit subregion of the frontal eye field projects to the caudate nucleus in monkeys
    Dong Mei Cui
    Department of Anatomy, University of Mississippi Medical Center, Jackson 39216 4505, USA
    J Neurophysiol 89:2678-84. 2003
    It has been well established by recording, inactivation, and neuroanatomical studies that the caudate nucleus is important for the control of saccadic eye movements...
  52. ncbi Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens
    J Uslaner
    Biopsychology Programs, Department of Psychology, University of Michigan, East Hall, 525 East University Street, Ann Arbor, MI 48019-1109, USA
    Brain Res 920:106-16. 2001
    ..The ability of environmental context to modulate psychostimulant drug-induced immediate early gene expression may be related to its ability to modulate forms of drug experience-dependent plasticity, such as behavioral sensitization...
  53. ncbi Adaptive local multi-atlas segmentation: application to the heart and the caudate nucleus
    Eva M van Rikxoort
    Image Sciences Institute, University Medical Center Utrecht, The Netherlands
    Med Image Anal 14:39-49. 2010
    ..In addition, AMAS was applied to an online segmentation challenge for delineation of the caudate nucleus in brain MRI scans where it achieved the best score of all results submitted to date.
  54. pmc Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder
    Erika E Forbes
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Loeffler 319, Pittsburgh, PA 15213, USA
    Am J Psychiatry 166:64-73. 2009
    ..The authors tested differences in reward-related brain function in healthy and depressed adolescents, and the authors examined direct links between reward-related brain function and positive mood that occurred in real-world contexts...
  55. ncbi Increased cortical thickness and caudate volume precede atrophy in PSEN1 mutation carriers
    Juan Fortea
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain
    J Alzheimers Dis 22:909-22. 2010
    ..Reactive neuronal hypertrophy or/and inflammation may account for increased CTh and decreased MD in asymptomatic MC...
  56. ncbi The role of the basal ganglia in learning and memory: neuropsychological studies
    Jessica A Grahn
    MRC Cognition and Brain Sciences Unit, Cambridge, UK
    Behav Brain Res 199:53-60. 2009
    ..In this review, we consider this broad literature in an attempt to define a specific role for the caudate nucleus in learning and memory, and in particular, how this role may differ from that of the putamen...
  57. ncbi The striatum beyond reward: caudate responds intensely to unpleasant pictures
    L Carretie
    Facultad de Psicologia, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Neuroscience 164:1615-22. 2009
    ..Analyses of variance showed that caudate nucleus was sensitive to the emotional content of stimulation, negative pictures eliciting greater caudate responses ..
  58. ncbi Hippocampal function and spatial memory: evidence from functional neuroimaging in healthy participants and performance of patients with medial temporal lobe resections
    Veronique D Bohbot
    Douglas Hospital Research Centre, Verdun, PQ, Canada
    Neuropsychology 18:418-25. 2004
    ..a significant activity of the hippocampus, whereas the response strategy led to a sustained activity in the caudate nucleus. Then, the authors administered the task to 15 patients with lesions to the medial temporal lobe, showing an ..
  59. ncbi A magnetic resonance spectroscopy investigation of obsessive-compulsive disorder and anxiety
    Stephen P Whiteside
    Department of Psychiatry and Psychology, West 11, Mayo Clinic, 200 First St SW, Rochester, MN 55905, United States
    Psychiatry Res 146:137-47. 2006
    ..Single voxel MRS was used to image the head of the caudate nucleus (HOC) and orbitofrontal white matter (OFWM) bilaterally in adult patients with OCD and a control group...
  60. pmc Theta burst stimulation-induced inhibition of dorsolateral prefrontal cortex reveals hemispheric asymmetry in striatal dopamine release during a set-shifting task: a TMS-[(11)C]raclopride PET study
    Ji H Ko
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Eur J Neurosci 28:2147-55. 2008
    ..impaired MCST performance and dopamine release in the ipsilateral caudate-anterior putamen and contralateral caudate nucleus, as compared to cTBS of the vertex (control)...
  61. ncbi Neuroprotective effects of progesterone on damage elicited by acute global cerebral ischemia in neurons of the caudate nucleus
    Miguel Cervantes
    Laboratorio de Neurofarmacologia, Centro de Investigacion Biomedica de Michoacan, Instituto Mexicano del Seguro Social IMSS, Morelia, Michoacan, Mexico
    Arch Med Res 33:6-14. 2002
    In addition to the hippocampus, the dorsolateral caudate nucleus (CN) and the pars reticularis of the substantia nigra (SNr) are among the most vulnerable brain areas to ischemia...
  62. ncbi Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers
    Dana M Small
    McConnell Brain Imaging Center, Montreal Neurological Institute and McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    Neuroimage 19:1709-15. 2003
    ..in binding potential was observed in the full compared to the hungry state in the dorsal putamen and caudate nucleus, indicative of dopamine release. There were no changes elsewhere in the striatum...
  63. ncbi Dissociating the role of the caudate nucleus and dorsolateral prefrontal cortex in the monitoring of events within human working memory
    Jean Sebastien Provost
    Functional Neuroimaging Unit, Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Eur J Neurosci 32:873-80. 2010
    ..However, the functional contribution of the caudate nucleus in the monitoring of events has not yet been studied...
  64. ncbi A neural correlate of reward-based behavioral learning in caudate nucleus: a functional magnetic resonance imaging study of a stochastic decision task
    Masahiko Haruno
    Computational Neuroscience Laboratories, Advanced Telecommunications Research Institute, Kyoto 619 0288, Japan
    J Neurosci 24:1660-5. 2004
    ..We found that activity in the caudate nucleus was correlated with short-term reward and, furthermore, paralleled the magnitude of a subject's behavioral ..
  65. ncbi Three-dimensional cartography of functional territories in the human striatopallidal complex by using calbindin immunoreactivity
    Carine Karachi
    INSERM U289, Neurologie et Thérapeutique Expérimentale, Hopital de la Salpetriere, 75013 Paris, France
    J Comp Neurol 450:122-34. 2002
    ..This three-dimensional partitioning of the human striatopallidal complex could help to define functional targets for high-frequency stimulation with greater accuracy and help to identify new stimulation sites...
  66. ncbi Caudate regional cerebral blood flow in obsessive-compulsive disorder, panic disorder and healthy controls on single photon emission computerised tomography
    J V Lucey
    Department of Psychological Medicine, St Bartholomew s and the Royal London School of Medicine and Dentistry, West Smithfield, UK
    Psychiatry Res 74:25-33. 1997
    ..The data suggest functional involvement of the right caudate nucleus is present in OCD.
  67. pmc Structural analysis of the basal ganglia in schizophrenia
    Daniel Mamah
    Department of Psychiatry, Washington University Medical School, St Louis, MO 63110, USA
    Schizophr Res 89:59-71. 2007
    ..In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences...
  68. ncbi Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus
    A P Strafella
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 21:RC157. 2001
    ..of the left dorsolateral prefrontal cortex caused a reduction in [(11)C]raclopride binding in the left dorsal caudate nucleus compared with rTMS of the left occipital cortex...
  69. ncbi Multisensory responses and receptive field properties of neurons in the substantia nigra and in the caudate nucleus
    Attila Nagy
    Department of Physiology, Faculty of Medicine, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Dom ter 10, H 6720 Szeged, Hungary
    Eur J Neurosci 22:419-24. 2005
    ..sensory responses and receptive field properties of the visual, auditory, somatosensory and multisensory caudate nucleus and substantia nigra pars reticulata neurons...
  70. ncbi Interaction between the human hippocampus and the caudate nucleus during route recognition
    Nicol C Voermans
    Department of Medical Psychology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neuron 43:427-35. 2004
    ..neural representations that are related to different memory systems with either the hippocampus or the caudate nucleus at their core...
  71. pmc Expression profiles of mitochondrial genes in the frontal cortex and the caudate nucleus of developing humans and mice selectively bred for high and low fear
    Kwang H Choi
    Department of Psychiatry, Center for the Study of Traumatic Stress, Uniformed Services University of the Health Sciences, Bethesda, Maryland, United States of America
    PLoS ONE 7:e49183. 2012
    ..genes and the functional categories associated with chronological age in the prefrontal cortex (PFC) and the caudate nucleus (CN) of psychiatrically normal humans ranging in age from birth to 50 years...
  72. ncbi Caudate nucleus volumes and genetic determinants of homocysteine metabolism in the prediction of psychomotor speed in older persons with depression
    Sharon Naismith
    School of Psychiatry, University of New South Wales, PO Box 1, Rozelle NSW 2039, Sydney, Australia
    Am J Psychiatry 159:2096-8. 2002
    The authors sought to determine whether caudate nucleus volumes or specific genotypes predict psychomotor slowing in older persons with depression.
  73. ncbi Visual receptive field properties of neurons in the caudate nucleus
    Attila Nagy
    Department of Physiology, Faculty of Medicine, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Dóm tér 10 H 6720 Szeged, Hungary
    Eur J Neurosci 18:449-52. 2003
    Visual single-unit activity was recorded in the caudate nucleus of halothane-anaesthetized, immobilized, artificially respirated cats. Visually sensitive neurons were found in the dorsolateral part of the caudate body...
  74. pmc 3D maps localize caudate nucleus atrophy in 400 Alzheimer's disease, mild cognitive impairment, and healthy elderly subjects
    S K Madsen
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles, School of Medicine, Los Angeles, CA, USA
    Neurobiol Aging 31:1312-25. 2010
    ..Normal caudate asymmetry (with the right 3.9% larger than left) was lost in AD, suggesting preferential right caudate atrophy. Automated caudate maps may complement other MRI-derived measures of disease burden in AD...
  75. pmc Reduced nucleus accumbens and caudate nucleus activation to a pleasant taste is associated with obesity in older adults
    Erin Green
    San Diego State University University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA 92120 4913, USA
    Brain Res 1386:109-17. 2011
    ..Significant associations between a hypofunctioning reward response and obesity suggest the hypothesis that decreased dopamine functioning may be a plausible mechanism for weight gain in older adults...
  76. pmc Regional ischemic vulnerability of the brain to hypoperfusion: the need for location specific computed tomography perfusion thresholds in acute stroke patients
    Seyedmehdi Payabvash
    Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Gray 241H, Boston, MA 02114 9657, USA
    Stroke 42:1255-60. 2011
    ..To characterize the spatial pattern of cerebral ischemic vulnerability to hypoperfusion in stroke patients...
  77. ncbi A manual and automated MRI study of anterior cingulate and orbito-frontal cortices, and caudate nucleus in obsessive-compulsive disorder: comparison with healthy controls and patients with schizophrenia
    Jem Riffkin
    Melbourne Neuropsychiatry Centre, University of Melbourne and Sunshine Hospital, Melbourne, Victoria, Australia
    Psychiatry Res 138:99-113. 2005
    ..brain structures including the orbito-frontal cortex (OFC), anterior cingulate cortex (ACC) and caudate nucleus (CN) are involved in the pathophysiology of obsessive-compulsive disorder (OCD), but structural imaging ..
  78. ncbi MRI study of caudate nucleus volume in Parkinson's disease with and without dementia with Lewy bodies and Alzheimer's disease
    Osvaldo P Almeida
    School of Psychiatry and Clinical Neurosciences, University of Western Australia, Nedlands, Australia
    Dement Geriatr Cogn Disord 16:57-63. 2003
    ..To examine the relationship between caudate volume and cognitive impairment, depression and movement disorder...
  79. ncbi Enhanced or impaired cognitive function in Parkinson's disease as a function of dopaminergic medication and task demands
    R Cools
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Cereb Cortex 11:1136-43. 2001
    ..on circuitry connecting the dorsolateral prefrontal cortex and the posterior parietal cortex to the dorsal caudate nucleus, which is profoundly DA-depleted in PD...
  80. ncbi Caudate nucleus hypointensity in the elderly is associated with markers of neurodegeneration on MRI
    Adriaan C G M van Es
    Department of Radiology, C2 S, Leiden University Medical Center, RC Leiden, The Netherlands A C G M van
    Neurobiol Aging 29:1839-46. 2008
    ..of both globus pallidus and putamen (group II; n=272; 66%), and hypointensity of globus pallidus, putamen and caudate nucleus (group III; n=111; 27%)...
  81. ncbi Melatonin: effects on dopaminergic and serotonergic neurons of the caudate nucleus of the striatum of male Syrian hamsters
    N A M Alexiuk
    Department of Human Anatomy and Cell Science, University of Manitoba, Winnipeg, Canada
    J Neural Transm 114:549-54. 2007
    ..The data suggest that the striatum may be a region in which dopaminergic neurons are subject to significant regulation by melatonin, either directly or through serotonergic neurons which synapse on dopaminergic neurons in the striatum...
  82. pmc Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome
    Yuko Kataoka
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Comp Neurol 518:277-91. 2010
    ..The selective deficit of PV+ and cholinergic striatal interneurons in TS subjects may result in an impaired cortico/thalamic control of striatal neuron firing in TS...
  83. ncbi Action and outcome encoding in the primate caudate nucleus
    Brian Lau
    Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 27:14502-14. 2007
    ..We recorded from phasically active neurons in the caudate nucleus while monkeys performed a probabilistically rewarded delayed saccade task...
  84. ncbi Morphine dependence changes the role of droperidol on pain-related electric activities in caudate nucleus
    Ying Zhang
    Department of Physiology, Harbin Medical University, Xuefu Road, No 174, Harbin 150081, China
    Biochem Biophys Res Commun 372:179-85. 2008
    ..on the pain-evoked response of pain-excitation neurons (PENs) and pain-inhibition neurons (PINs) in the caudate nucleus (Cd) of rats. The trains of electric impulses applied to the sciatic nerve were used as noxious stimulation...
  85. ncbi Caudate nucleus: influence of dopaminergic input on sequence learning and brain activation in Parkinsonism
    Maren Carbon
    Center for Neurosciences, North Shore Long Island Jewish Research Institute, New York, NY 11030, USA
    Neuroimage 21:1497-507. 2004
    ..that (1) the acquisition of sequential information is related to the integrity of dopaminergic input to the caudate nucleus; and (2) the integrity of dopaminergic input to the caudate nucleus correlates significantly with brain ..
  86. ncbi A neural correlate of response bias in monkey caudate nucleus
    Johan Lauwereyns
    Laboratory of Sensorimotor Research, National Eye Institute, Building 49, Room 2A50, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 418:413-7. 2002
    ..Here we identify neurons in the monkey caudate nucleus that create a spatially selective response bias depending on the expected gain...
  87. pmc Encoding of both positive and negative reward prediction errors by neurons of the primate lateral prefrontal cortex and caudate nucleus
    Wael F Asaad
    Rhodan Center for Nervous System Repair, Department of Neurosurgery, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Neurosci 31:17772-87. 2011
    ..We examined the activity of neurons in the lateral prefrontal cortex (PFC) and caudate nucleus of monkeys as they performed a trial-and-error learning task...
  88. ncbi Oxytocin in the rat caudate nucleus influences pain modulation
    Jun Yang
    College of Pharmacy, Xinxiang Medical University, Xixiang, Henan, China
    Peptides 32:2104-7. 2011
    ..Many studies have found that caudate nucleus (CdN) enriches OXT and OXT receptors by the methods of historadioautograph and gene expression...
  89. ncbi The measurement of R2, R2* and R2' in HIV-infected patients using the prime sequence as a measure of brain iron deposition
    K A Miszkiel
    Department of Radiology at UCL Hospitals NHS Trust, London, UK
    Magn Reson Imaging 15:1113-9. 1997
    Brain iron deposition was assessed at 1.5 T in the caudate nucleus, globus pallidus and frontal and parieto-occipital white matter in 28 human immunodeficiency virus (HIV)-infected patients and 15 control subjects with a new Partially ..
  90. ncbi Prefrontal cortex and caudate nucleus in conditional associative learning: dissociated effects of selective brain lesions in rats
    G Winocur
    Rotman Research Institute of Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
    Behav Neurosci 112:89-101. 1998
    Rats with lesions to prefrontal cortex (PFC) or caudate nucleus (CN) were compared on tests of conditional associative learning (CAL) that placed varying demands on conditional rule learning and working-with-memory operations that are ..
  91. ncbi A quantitative magnetic resonance imaging study of caudate and lenticular nucleus gray matter volume in primary unipolar major depression: relationship to treatment response and clinical severity
    S S Pillay
    Brain Imaging Center, McLean Hospital, Belmont, MA 02178, USA
    Psychiatry Res 84:61-74. 1998
    ..Female treatment responders tended to have larger caudate nucleus volumes than male 'responders', and also larger right caudate nucleus volumes than their female 'non-..
  92. ncbi Caudate nucleus and social cognition: neuropsychological and SPECT evidence from a patient with focal caudate lesion
    Jennifer Kemp
    Universite de Strasbourg CNRS, Strasbourg, France
    Cortex 49:559-71. 2013
    ..of such lesions on social cognition, we tested a selected patient, MVG, a 44-year-old man with a focal caudate nucleus (CN) lesion following stroke...
  93. ncbi Why do we have a caudate nucleus?
    Jaime R Villablanca
    Department of Psychiatry and Biobehavioral Sciences, Department of Neurobiology, UCLA Intellectual and Developmental Disabilities Research Center, Brain Research Institute, The David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Acta Neurobiol Exp (Wars) 70:95-105. 2010
    In order to understand the physiological role of the caudate nucleus, we combine here our laboratory data on cats with reports of patients with selective damage to this nucleus...
  94. ncbi Volume reduction in the caudate nucleus following stereotactic placement of lesions in the anterior cingulate cortex in humans: a morphometric magnetic resonance imaging study
    S L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    J Neurosurg 93:1019-25. 2000
    ..The goal of this study was to test hypotheses regarding changes in volume in subcortical structures following anterior cingulotomy...
  95. ncbi Effect of clozapine on caudate nucleus volume in relation to symptoms of schizophrenia
    F E Scheepers
    University Medical Center, Department of Psychiatry A00 241, P O Box 85500, 3508 GA Utrecht, Netherlands
    Am J Psychiatry 158:644-6. 2001
    ..In the current study the authors examined whether this volume decrease was related to clinical improvement...
  96. ncbi Olanzapine increases grey and white matter volumes in the caudate nucleus of patients with schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 55:43-6. 2007
    There are inconsistent reports regarding the caudate nucleus volume in patients with schizophrenia compared with healthy subjects...
  97. ncbi Involvement of mechanisms dependent on NMDA receptors, nitric oxide and protein kinase A in the hippocampus but not in the caudate nucleus in memory
    J Quevedo
    , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 8:713-7. 1997
    ..step-down inhibitory avoidance task, and rats unilaterally implanted in the left posteroventral region of the caudate nucleus were trained and tested in a cued water maze task...
  98. ncbi MRI analysis of an inherited speech and language disorder: structural brain abnormalities
    K E Watkins
    Developmental Cognitive Neuroscience Unit, Institute of Child Health, University College London Medical School, London, UK
    Brain 125:465-78. 2002
    ..Several of these regions were abnormal bilaterally, including the caudate nucleus, which was of particular interest because this structure was also found to show functional abnormality in a ..
  99. ncbi Effects of the antipsychotic risperidone on dopamine synthesis in human brain measured by positron emission tomography with L-[beta-11C]DOPA: a stabilizing effect for dopaminergic neurotransmission?
    Hiroshi Ito
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    J Neurosci 29:13730-4. 2009
    ..The therapeutic effects of risperidone in schizophrenia might be related to such stabilizing effects on dopaminergic neurotransmission responsivity...
  100. ncbi Neurobehavioral changes associated with bilateral caudate nucleus infarctions
    Jin Narumoto
    Psychiatry Clin Neurosci 59:109-10. 2005
  101. pmc Shape abnormalities of caudate nucleus in schizotypal personality disorder
    James J Levitt
    Laboratory of Neuroscience, Department of Psychiatry, Veterans Affairs Boston Healthcare System, Brockton Division, Harvard Medical School, Brockton, MA, USA
    Schizophr Res 110:127-39. 2009
    Previously, we reported abnormal volume and global shape in the caudate nucleus in schizotypal personality disorder (SPD)...

Research Grants62

  1. Neural Functioning of Feeding Centers in Obese Youth
    ROBERT STANLEY SHERWIN; Fiscal Year: 2013
    ..fMRI mapping to examine the connections between specific appetitive regions such as the dorsal striatum and caudate nucleus and the hypothalamus...
  2. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..tissue samples from different brain regions {raphe nuclei, hypothalamus, hippocampus, basal ganglia (caudate nucleus, putamen, globus pallidus), substantia nigra, amygdala and fronto-cortical regions (cingulate and subgenual ..
  3. In vivo magnetic resonance-based analysis of inherited neurologic disease after g
    HEATHER G EDWARDS; Fiscal Year: 2013
    ..scanner and quantitative measurements will be taken of cortical and subcortical targets such as the thalamus, caudate nucleus and brain stem...
  4. Pilot Clinical Trial of Deep Brain Stimulation for Tinnitus
    Paul Larson; Fiscal Year: 2013
    ..By applying deep brain stimulation (DBS) to area LC of the caudate nucleus, pathological neural activity with perceptual consequences will either be eliminated or ignored...
  5. Huntington's Disease and Neurogenesis
    Lisa M Ellerby; Fiscal Year: 2012
    ..and immature neuronal markers has been observed in the subventricular zone (SVZ) adjacent to the caudate nucleus in brains of patients with HD...
  6. Effects of mGluR2/3 Activation on Cue-Induced Cocaine Relapse in Squirrel Monkeys
    Daniel F Manvich; Fiscal Year: 2010
    ..are localized in brain regions known to be involved in the reinforcing effects of cocaine, such as the caudate nucleus, nucleus accumbens (NAcc), prefrontal cortex, and amygdala...
  7. EXTRAPYRAMIDAL SYSTEMS
    Ann M Graybiel; Fiscal Year: 2013
    ..nodes of this circuitry (medial prefrontal cortex, anterior cingulate cortex) as well as in the striatum (caudate nucleus) during decision-making, and to apply state-of-the-art methods for analyzing the circuit dynamics of this ..
  8. Basal Ganglia Involvement in Conditioning the Trace Eyeblink Reflex
    Luke C Flores; Fiscal Year: 2010
    ..study will take recordings from, permanently lesion, temporally inactive, and neurochemically deplete the caudate nucleus, a major site of cortical and thalamic input into the basal ganglia...
  9. Multi-channel Enhancement and Validation of Subcortical Morphometry in HIV
    Christine Fennema Notestine; Fiscal Year: 2010
    ..supported the value of neuroimaging for identifying biomarkers in HIV, particularly in the white matter and caudate nucleus. Recent clinical neuroimaging efforts within the multi-site CNS HIV Anti-Retroviral Therapy Effects Research (..
  10. Computational Morphometry in Schizophrenia and Related Disorders
    Sylvain Bouix; Fiscal Year: 2013
    ..e., caudate nucleus in SPDs and amygdala-hippocampus in patients with schizophrenia)...
  11. Forebrain-Cerebellar Interaction During Learning
    John F Disterhoft; Fiscal Year: 2012
    ..of the conditioning network are located in SI cortex, entorhinal (EC) and/or perirhinal (PR) cortex, and caudate nucleus. Five specific aims will determine if there are increases in activity suitable to potentiate the input to the ..
  12. SYNAPTIC MECHANISMS OF THE GLOBUS PALLIDUS
    RONALD HUFFMAN; Fiscal Year: 1980
    ..Stimulation of the caudate nucleus resulted in inhibition of spontaneous firing of globus pallidus neurons; the duration of this inhibition was ..
  13. Restoration of Dopaminergic Function in Parkinson's Disease
    Greg Gerhardt; Fiscal Year: 2009
    ..coupled with electrochemical detection (HPLC-EC) to study DA neuronal systems in the striatum (putamen and caudate nucleus) and substantia nigra of Rhesus monkeys that have received chronic GDNF infusions...
  14. The neural substrates of repetitive behaviors in autism
    Kelli Dominick; Fiscal Year: 2010
    ..children and adolescents with autism and non-autistic children in brain regions previously related to RB, the caudate nucleus and the anterior cingulate gyrus...
  15. BRAIN MORPHOLGY IN OBSESSIVE-COMPULSIVE DISORDER
    Delbert Robinson; Fiscal Year: 1993
    ..measure of change in volume of the hemispheres, thalamus and basal ganglia); 5) the basal ganglia (the caudate nucleus, nucleus accumbens and putamen); 6) and whole brain (to determine if changes in volume of the above ..
  16. EXCITATORY SYNAPTIC TRANSMISSION IN NEOSTRIATUM
    David Lovinger; Fiscal Year: 2000
    ..Glutamate or a related amino acid is the major excitatory neurotransmitter in the mammalian CNS. Within the caudate nucleus and putamen, glutamate- containing fibers from the cortex and possibly thalamus form synapses with neurons, ..
  17. SPECT IMAGING IN PARKINSONIAN MODEL
    John Seibyl; Fiscal Year: 2000
    ..iodophenyl)tropane, has been demonstrated to be an effective marker of dopamine reuptake sites in the caudate nucleus and the putamen...
  18. BIOGENIC AMINE LEVELS IN VIVO AND PITUITARY FUNCTION
    JAMES VOOGT; Fiscal Year: 1980
    ..The primary brain areas to be studied include the arcuate-median eminence area, The preoptic area and the caudate nucleus. With this study a better understanding of what change in biogenic amine release occurs in the central ..
  19. COGNITIVE EFFECTS OF BENZODIAZEPINES-NEURONAL SUBSTRATES
    Martin Sarter; Fiscal Year: 1992
    ..The regions selected include the globus pallidus, dentate,gyrus, basolateral amygdala, caudate nucleus, substantia innominata, and locus coeruleus...
  20. EFFECTS OF PHENCYCLIDINE ON NEURONAL FUNCTION
    Robert Freedman; Fiscal Year: 1991
    ..and prefrontal cortex electrophysiologically, and we have studied PCP effects on dopamine release in the caudate nucleus. We will electrophysiologically characterize PCP interactions with norepinephrine synapses in the prefrontal ..
  21. COGNITIVE EFFECTS OF NEONATAL LEAD EXPOSURE IN MONKEYS
    Robert Bowman; Fiscal Year: 1993
    ..exposures) may be explained by sensory inattention resulting from damage to dopaminergic systems of the caudate nucleus, induced by Pb exposure during postnatal development in the monkey...
  22. Imaging the Serotonin System in Obsessive-Compulsive Disorder
    Helen Simpson; Fiscal Year: 2009
    ..that OCD results from a malfunctioning brain circuit that includes the orbitofrontal cortex (OFC), the caudate nucleus, and the thalamus...
  23. Functional Neuroanatomy of Obsessive Compulsive Disorder
    Stephan Taylor; Fiscal Year: 2009
    ..the limbic-related components of the loops (orbitofrontal cortex [OFC], anterior cingulate cortex [OFC], and caudate nucleus [CN]), but the significance of these findings remains unclear...
  24. NARCOTIC ACTION IN DEPRESSED BRAIN
    ALEXANDER BECKMAN; Fiscal Year: 1992
    ..solubility than morphine; 3) tolerance to morphine analgesic and nonanalgesic actions; 4) morphine effects on caudate nucleus dopamine (DA) metabolism...
  25. STRIATAL AMPA RECEPTOR PATHOLOGY IN SCHIZOPHRENIA
    JOHN NOGA; Fiscal Year: 2002
    ..Noga's preliminary finding of increased AMPA receptor binding in caudate nucleus in schizophrenia using a new, larger sample of striatal tissue (n=31 schizophrenia; 31 normals, 22 bipolars ..
  26. Magnetic Resonance Spectroscopy in Affective Illness
    CONSTANCE MOORE; Fiscal Year: 2005
    ..Decreased right cingulate cortex Ino will be associated with depression. Decreased caudate nucleus beta-NTP will be associated with depression...
  27. BRAIN ASYMMETRY AND LANGUAGE DEVELOPMENT
    Christiana Leonard; Fiscal Year: 1999
    ..changes in structures not thought to be primarily involved in language development -- the corpus callosum, caudate nucleus and the hippocampus, will be measured to examine the specificity of the findings...
  28. NEUROIMAGING IN HIV INFECTION
    Colin Hall; Fiscal Year: 2001
    ..in the Abstract): (1) That the ratio of N-acetyl aspartate to creatinine (NAA/Cr) in white matter and in the caudate nucleus will be lower in HIV-infected persons than in matched controls due to reduction in NAA, and that the ratio ..
  29. NEUROBIOLOGY OF MULTIPLE MEMORY SYSTEMS
    Mark Packard; Fiscal Year: 2001
    ..will be accomplished through experimental linkage of two sets of previous findings: 1) the hippocampus and caudate nucleus are parts of independent brain systems, and 2) the amygdala plays a modulatory role in memory, and can ..
  30. Predictors of Treatment Response in Late-Life Depression
    Howard Aizenstein; Fiscal Year: 2006
    ..e., the anterior cingulate cortex (ACC), dorsolateral prefrontal cortex (DLPFC), caudate nucleus, and hippocampus...
  31. THE BASAL GANGLIA AND AGING
    THOMAS MCNEILL; Fiscal Year: 1990
    ..of age-correlated morphological changes in neurotransmitter and neuropeptide neurons of the striatum (caudate nucleus and putamen) and substantia nigra (SN) in the C57BL/6NNia mouse using integrated immunocytochemical, ..
  32. Neuronal transport of gp120
    Italo Mocchetti; Fiscal Year: 2005
    ..In particular, we will inject gp120 into the caudate nucleus or fimbria and examine gp120 immunoreactivity in the substantia nigra and septal nuclei, respectively...
  33. Imaging of dopamine function in schizophrenia
    Marc Laruelle; Fiscal Year: 2005
    ..in schizophrenia is not elevated in the ventral striatum, as anticipated, but in the precommissural dorsal caudate nucleus (preDCA), and that elevated preDCA DA transmission is related to antipsychotic efficacy...
  34. The amygdala & cortical receptive field plasticity
    NORMAN WEINBERGER; Fiscal Year: 2006
    ..kinds of training and that the modulation involves BLA influences on other brain regions including the caudate nucleus, hippocampus and entorhinal cortex...
  35. NEUROLOGICAL SUBSTRATES IN THE INITIATION OF MOVEMENT
    Edgar Garcia Rill; Fiscal Year: 1980
    ..electrophysiological studies revealed a topographic axio-distal distribution of motor cortex outputs to the caudate nucleus. Experiments carried out during this year revealed how this axio-distal sorting within the caudate nucleus is ..
  36. NEURAL CIRCUITRY AND COGNITIVE FUNCTION IN SCHIZOPHRENIA
    Richard Keefe; Fiscal Year: 1999
    ..the neural circuits connecting the prefrontal cortex with the thalamus and the hippocampus via the caudate nucleus, entorhinal cortex and parahippocampal gyrus...
  37. Neuroimaging Studies of Depression in Parkinson's Disease
    LEE BLONDER; Fiscal Year: 2009
    ..significant reductions in the volume of the caudate nucleus, orbitofrontal cortex, medial frontal cortex, anterior cingulate, and amygdala;and 2...
  38. GENE DELIVERY TO THE PRIMATE CNS--VIRAL VECTORS
    D Redmond; Fiscal Year: 2000
    ..assess cognitive and motor effects of vector-delivered GDNF in two brain areas, the prefrontal cortex and the caudate nucleus, after MPTP-induced dopamine depletions in monkeys...
  39. PHARMACOLOGY OF SYNAPTIC TRANSMISSION IN THE BRAIN
    RAINER SPEHLMANN; Fiscal Year: 1980
    This project proposes a neurophysiological and neuropharmacological study of the caudate nucleus in a model of Parkinson's disease produced by the interruption of the nigrostriatal pathway in cats...
  40. Automated monitoring of MRI abnormalities in HIV/AIDS
    Eric Halgren; Fiscal Year: 2005
    ..structures suggests that specific neuropsychological problems are associated with decreased volume of the caudate nucleus. However, the expertise and time required to perform these manual measurements severely limit their ..
  41. Neural basis of category learning
    SHAWN ELL; Fiscal Year: 2006
    ..in the explicit system is assumed to rely primarily upon frontal cortical structures and the head of the caudate nucleus whereas the implicit system depends primarily upon the tail of the caudate nucleus and high-level motor ..
  42. AGING OF CENTRAL DOPAMINERGIC SYSTEMS IN PRIMATES
    Don Gash; Fiscal Year: 2007
    ..our studies focus on the dopamine (DA) neurons in the substantia nigra (SN) and their projections to the caudate nucleus, putamen and globus pallidus of the basal ganglia...
  43. Degraded Rationality: Subclinical Neuropathology and Neuroeconomic Behavior in Ol
    David Bennett; Fiscal Year: 2009
    ..support affective decision making including nucleus accumbens, orbital frontal cortex, amygdala, anterior caudate nucleus, and anterior insular cortex...
  44. EXTRACELLULAR NEUROCHEMISTRY AND SUBSTANCE ABUSE
    ADRIAN MICHAEL; Fiscal Year: 2003
    ..With these devices, the impact of drugs on the regulation of the spatiotemporal distribution of dopamine in the extracellular space of the caudate nucleus and nucleus accumbens of the rat will be observed.
  45. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  46. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  47. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  49. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  50. Functional neuroanatomical deficits in ADHD families
    BETTY CASEY; Fiscal Year: 2003
    ..Imaging will be performed at corresponding imaging sites at DUMC, Weill Medical College of Cornell University, and Stanford University respectively. ..
  51. Discovery of Novel Pharmacotherapies: Cocaine Dependence
    PETER MELTZER; Fiscal Year: 2008
    ..vi) analogues of pyrovalerone. ..
  52. Brain and Behavioral Alterations After Methamphetamine
    William Melega; Fiscal Year: 2004
    ..This paradigm will represent a validated primate model to evaluate the efficacy of pharmacotherapies designed for treatment of neurological and behavioral deficits associated with human METH abuse. ..
  53. Protein Molecular Imaging in Patients with Late-Life Major Depression
    Anand Kumar; Fiscal Year: 2008
    ..This will facilitate the early identification of patients who may benefit from aggressive therapy aimed at alleviating both mood and cognitive symptoms. [unreadable] [unreadable] [unreadable]..
  54. Hemodynamic predictors of brain and cognitive aging
    Naftali Raz; Fiscal Year: 2005
    ....
  55. NEURAL CORRELATES OF AGE RELATED DIFFERENCES IN MEMORY
    Naftali Raz; Fiscal Year: 2003
    ....
  56. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2005
    ....
  57. Neurobiological Circuits of Gain and Loss During Risky Decision Making
    Gregory S Berns; Fiscal Year: 2010
    ....
  58. Neuroimaging of Genetically-Defined Incipient CJD
    Isak Prohovnik; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  59. INTEGRATION OF BIFURCATION THEORY AND CONTINUOUS FMRI
    Gregory Berns; Fiscal Year: 2002
    ..The integration of bifurcation theory with continuous fMRI is anticipated to have a significant impact on the way in which fMRI experiments are conducted and will yield new techniques for the study of neuropsychiatric illness. ..
  60. Frontal White Matter and Impulsivity in Schizophrenia
    Matthew Hoptman; Fiscal Year: 2007
    ..A secondary aim will examine the relationship between FA and violence. Understanding the neural basis of impulsivity in schizophrenia would help identify at-risk patients and inform new treatment approaches. ..
  61. Depression Prevention Program for High-Risk Adolescents
    Eric Stice; Fiscal Year: 2008
    ..Thus, the proposed project should provide a rigorous evaluation of this promising brief prevention program and should advance knowledge regarding the prevention of this pernicious psychiatric problem. [unreadable] [unreadable]..