neostriatum

Summary

Summary: The phylogenetically newer part of the CORPUS STRIATUM consisting of the CAUDATE NUCLEUS and PUTAMEN. It is often called simply the striatum.

Top Publications

  1. ncbi Different time courses of learning-related activity in the prefrontal cortex and striatum
    Anitha Pasupathy
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USA
    Nature 433:873-6. 2005
  2. pmc Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
    Mathias Pessiglione
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 442:1042-5. 2006
  3. ncbi Functional diversity and specificity of neostriatal interneurons
    James M Tepper
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Curr Opin Neurobiol 14:685-92. 2004
  4. ncbi Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum
    Wakoto Matsuda
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci 29:444-53. 2009
  5. pmc Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 20:4822-30. 2011
  6. ncbi GABAergic microcircuits in the neostriatum
    James M Tepper
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Trends Neurosci 27:662-9. 2004
  7. ncbi Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    J H Kordower
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Science 290:767-73. 2000
  8. pmc Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF
    A Benraiss
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Gene Ther 19:483-93. 2012
  9. pmc Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice
    M A Hickey
    Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, Reed Neurological Research Center B114, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neuroscience 157:280-95. 2008
  10. pmc GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum
    Knut Kirmse
    Institute of Neurophysiology, Johannes Müller Centre of Physiology, Charite University Medicine Berlin, Tucholskystr 2, 10117 Berlin, Germany
    J Physiol 586:5665-78. 2008

Research Grants

  1. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2011
  2. A Tonically Active Network in the Neostriatum
    Charles J Wilson; Fiscal Year: 2013
  3. Transcriptional regulation of aging in the adult neural stem cell niche
    HOOMAN TROY GHASHGHAEI; Fiscal Year: 2013
  4. Huntington's Disease and Neurogenesis
    Lisa M Ellerby; Fiscal Year: 2012
  5. Amphetamine sensitization in a model of schizophrenia
    Russell W Brown; Fiscal Year: 2010
  6. Functional Striatal Microcircuits in vivo and in vitro
    James M Tepper; Fiscal Year: 2013
  7. Endogenous GABAergic Activity
    Istvan Mody; Fiscal Year: 2013
  8. Neostriatum in Learning and Memory
    Emad N Eskandar; Fiscal Year: 2013
  9. A Novel Ionic Mechanism of Ischemic Neuronal Injury
    Ping Deng; Fiscal Year: 2012
  10. Ethanol Effects on Neostriatal Function
    Henry Yin; Fiscal Year: 2010

Detail Information

Publications281 found, 100 shown here

  1. ncbi Different time courses of learning-related activity in the prefrontal cortex and striatum
    Anitha Pasupathy
    The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 USA
    Nature 433:873-6. 2005
    ..These results support the hypothesis that rewarded associations are first identified by the basal ganglia, the output of which 'trains' slower learning mechanisms in the frontal cortex...
  2. pmc Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans
    Mathias Pessiglione
    Wellcome Department of Imaging Neuroscience, 12 Queen Square, London WC1N 3BG, UK
    Nature 442:1042-5. 2006
    ..We conclude that dopamine-dependent modulation of striatal activity can account for how the human brain uses reward prediction errors to improve future decisions...
  3. ncbi Functional diversity and specificity of neostriatal interneurons
    James M Tepper
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, New Jersey 07102, USA
    Curr Opin Neurobiol 14:685-92. 2004
    ..Both classes of interneurons are important sites of action of neuromodulators in neostriatum, and act in different but complementary ways to modify the activity of the spiny projection neurons.
  4. ncbi Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum
    Wakoto Matsuda
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci 29:444-53. 2009
    ..hydroxylase-positive dopaminergic neurons possessed widely spread and highly dense axonal arborizations in the neostriatum. All of them emitted very little axon collateral arborization outside of the striatum except for tiny ..
  5. pmc Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1
    Leroy Hubert
    Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Hum Mol Genet 20:4822-30. 2011
    ..These results validate our original findings in cultured human cells and suggest that transcription may induce NER-dependent TNR instability in neuronal tissues in humans...
  6. ncbi GABAergic microcircuits in the neostriatum
    James M Tepper
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, NJ 07102, USA
    Trends Neurosci 27:662-9. 2004
    ..An important feature of the functional organization of the neostriatum has long been assumed to be the existence of a widespread lateral inhibitory network mediated by the axon ..
  7. ncbi Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    J H Kordower
    Department of Neurological Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Science 290:767-73. 2000
    ..These data indicate that GDNF delivery using a lentiviral vector system can prevent nigrostriatal degeneration and induce regeneration in primate models of PD and might be a viable therapeutic strategy for PD patients...
  8. pmc Sustained induction of neuronal addition to the adult rat neostriatum by AAV4-delivered noggin and BDNF
    A Benraiss
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14620, USA
    Gene Ther 19:483-93. 2012
    ..BDNF) and noggin is sufficient to induce the heterotopic recruitment of new medium spiny neurons to the adult neostriatum, from endogenous subependymal neural progenitor cells...
  9. pmc Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice
    M A Hickey
    Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, Reed Neurological Research Center B114, 710 Westwood Plaza, Los Angeles, CA 90095, USA
    Neuroscience 157:280-95. 2008
    ..Accordingly, they provide a useful model to elucidate early mechanisms of pathophysiology and the progression to overt neurodegeneration...
  10. pmc GABA transporter 1 tunes GABAergic synaptic transmission at output neurons of the mouse neostriatum
    Knut Kirmse
    Institute of Neurophysiology, Johannes Müller Centre of Physiology, Charite University Medicine Berlin, Tucholskystr 2, 10117 Berlin, Germany
    J Physiol 586:5665-78. 2008
    GABAergic medium-sized striatal output neurons (SONs) provide the principal output for the neostriatum. In vitro and in vivo data indicate that spike discharge of SONs is tightly controlled by effective synaptic inhibition...
  11. pmc Comparison of microRNA expression in hippocampus and the marginal division (MrD) of the neostriatum in rats
    Si Yun Shu
    Center of Pediatrics, Zhujiang Hospital, Southern Medical University, 510280, Guangzhou, Guangdong, China
    J Biomed Sci 20:9. 2013
    ..This study represents the first attempt to perform a profiling analysis of the differential expression of miRNAs between hippocampus and the Marginal division (MrD) of the neostriatum in the rat brain.
  12. ncbi Stress-induced dopamine release in humans at risk of psychosis: a [11C]raclopride PET study
    Alexandra Soliman
    McConnell Brain Imaging Centre, Montreal Neurological Institute, Montreal, Canada
    Neuropsychopharmacology 33:2033-41. 2008
    ..Our findings suggest the presence of abnormalities in the dopamine response to stress in negative symptom schizotypy, and provide indirect evidence of a link to frontal function...
  13. pmc Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice
    Agathi Vassiliki Goula
    Department of Neurobiology and Genetics, Institute of Genetics and Molecular and Cellular Biology, UMR 7104 CNRS INSERM UdS, Illkirch, France
    PLoS Genet 5:e1000749. 2009
    ..We propose that the stoichiometry of BER enzymes is one critical factor underlying the tissue selectivity of somatic CAG expansion...
  14. ncbi Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptors
    Eun Sang Choe
    Division of Pharmacology, School of Pharmacy, University of Missouri Kansas City, 2411 Holmes St, M3 C15, Kansas City, MO 64108, USA
    Neuropsychopharmacology 27:565-75. 2002
    ..These data suggest that acute amphetamine is able to facilitate the phosphorylation of CREB, Elk-1, and ERK1/2 signaling proteins and Fos gene expression via a group I mGluR-dependent mechanism in the dorsal striatum...
  15. ncbi Difference in organization of corticostriatal and thalamostriatal synapses between patch and matrix compartments of rat neostriatum
    Fumino Fujiyama
    Department of Morphological Brain Science, Graduate School of Medicine, Faculty of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Eur J Neurosci 24:2813-24. 2006
    The neostriatum, which possesses a mosaic organization consisting of patch and matrix compartments, receives glutamatergic excitatory afferents from the cerebral cortex and thalamus...
  16. pmc Striatal plasticity and basal ganglia circuit function
    Anatol C Kreitzer
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 60:543-54. 2008
    ..Here, we review current understanding of synaptic plasticity in the striatum and its role in the physiology and pathophysiology of basal ganglia function...
  17. pmc Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice
    Sergey V Shmelkov
    1 Howard Hughes Medical Institute, Ansary Stem Cell Institute and Department of Genetic Medicine, Weill Cornell Medical College, New York, New York, USA 2 These authors contributed equally to this work
    Nat Med 16:598-602, 1p following 602. 2010
    ..Thus, our studies identify Slitrk5 as an essential molecule at corticostriatal synapses and provide a new mouse model of OCD-like behaviors...
  18. ncbi Regulation of phosphorylation of the GluR1 AMPA receptor in the neostriatum by dopamine and psychostimulants in vivo
    G L Snyder
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, New York 10021, USA
    J Neurosci 20:4480-8. 2000
    ..The phosphorylation of Ser(845), but not Ser(831), was strongly increased in neostriatum in vivo in response to the psychostimulants cocaine and methamphetamine...
  19. ncbi Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals
    Nigel S Bamford
    Department of Neurology, University of Washington, Children s Hospital and Regional Medical Center, Seattle, WA 98105 USA
    Neuron 42:653-63. 2004
    ..Thus, dopamine, by filtering less active inputs, appears to reinforce specific sets of corticostriatal synaptic connections...
  20. ncbi Dual cholinergic control of fast-spiking interneurons in the neostriatum
    Tibor Koos
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    J Neurosci 22:529-35. 2002
    GABAergic interneurons appear to play a fundamental role in the functioning of the neostriatum by modulating the spiking of striatal projection neurons with great efficacy...
  21. ncbi Adenoviral brain-derived neurotrophic factor induces both neostriatal and olfactory neuronal recruitment from endogenous progenitor cells in the adult forebrain
    A Benraiss
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci 21:6718-31. 2001
    ..Importantly, AdBDNF-associated neuronal recruitment to the neostriatum was also noted, with the treatment-induced addition of BrdU(+)-NeuN(+)-betaIII-tubulin(+) neurons to the ..
  22. ncbi Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease
    M S Levine
    Mental Retardation Research Center, University of California at Los Angeles, 90095, USA
    J Neurosci Res 58:515-32. 1999
    ..These findings imply that NMDA antagonists or compounds that alter sensitivity of NMDA receptors may be useful in the treatment of HD...
  23. pmc Acupuncture enhances the synaptic dopamine availability to improve motor function in a mouse model of Parkinson's disease
    Seung Nam Kim
    Studies of Translational Acupuncture Research, Acupuncture and Meridian Science Research Center, Kyung Hee University, Seoul, Republic of Korea
    PLoS ONE 6:e27566. 2011
    ..These results suggest that the acupuncture-induced enhancement of synaptic dopamine availability may play a critical role in motor function improvement against MPTP...
  24. pmc Transcription elongation and tissue-specific somatic CAG instability
    Agathi Vasiliki Goula
    Programme of Translational Medicine and Neurogenetics, Institute of Genetics and Molecular and Cellular Biology, UMR 7104 CNRS INSERM UdS, Illkirch, France
    PLoS Genet 8:e1003051. 2012
    ..More specifically, our results suggest for the first time that transcription elongation is regulated in a tissue-dependent manner, contributing to tissue-selective CAG instability...
  25. ncbi Differential roles of monkey striatum in learning of sequential hand movement
    S Miyachi
    Laboratory of Neural Control, National Institute for Physiological Sciences, Okazaki, Japan
    Exp Brain Res 115:1-5. 1997
    ..These results suggest that the anterior and posterior portions of the striatum participate in different aspects of learning of sequential movements...
  26. ncbi Complementary acupuncture in Parkinson's disease: a spect study
    Yong Huang
    School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China
    Int J Neurosci 120:150-4. 2010
    ..Thus, complementary acupuncture treatment in Parkinson's disease may affect rCBF but not basal ganglion DAT...
  27. pmc Quantification of age-dependent somatic CAG repeat instability in Hdh CAG knock-in mice reveals different expansion dynamics in striatum and liver
    Jong Min Lee
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23647. 2011
    ..Investigation of the dynamics of the CAG repeat size changes over time may provide insights into the mechanisms underlying CAG repeat instability...
  28. ncbi Cognitive impairments after lesions of the neostriatum caudolaterale and its thalamic afferent in pigeons: functional similarities to the mammalian prefrontal system?
    O Gunturkun
    Department of Psychology, Ruhr University Bochum, Germany
    J Hirnforsch 38:133-43. 1997
    Several studies suggest that the neostriatum caudolaterale (NCL) of birds is equivalent to the mammalian prefrontal cortex (PFC). The aim of the present study was to analyze the functional importance of the NCL and the n...
  29. pmc Dopamine D2 receptor levels in striatum, thalamus, substantia nigra, limbic regions, and cortex in schizophrenic subjects
    Robert M Kessler
    Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Biol Psychiatry 65:1024-31. 2009
    ..Studies in schizophrenic patients have reported dopaminergic abnormalities in striatum, substantia nigra, thalamus, anterior cingulate, hippocampus, and cortex that have been related to positive symptoms and cognitive impairments...
  30. pmc Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats
    B Meyers
    Department of Neurobiology and Behavior, Stony Brook University, Stony Brook, NY 11794 5230, USA
    Neuroscience 165:850-62. 2010
    ....
  31. ncbi Structural covariance of the neostriatum with regional gray matter volumes
    C Soriano-Mas
    Psychiatry Department, Bellvitge University Hospital IDIBELL, Feixa Llarga s n, 08907 Barcelona, Spain
    Brain Struct Funct 218:697-709. 2013
    ..Finally, the potential mechanisms underpinning the phenomenon of volume correlations between distant cortico-striatal structures are also discussed...
  32. pmc Lasting reduction of cocaine action in neostriatum--a hydrolase gene therapy approach
    Yang Gao
    Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA
    J Pharmacol Exp Ther 330:449-57. 2009
    ..p.). Immunohistochemistry of the neostriatum on day 7 showed many FosB-reactive nuclei in unprotected rats but few if any in rats pretreated with active ..
  33. ncbi Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: a quantitative autoradiographic and immunocytochemical analysis
    L Descarries
    Department de Physiologie, Universite de Montreal, Quebec, Canada
    J Comp Neurol 375:167-86. 1996
    Dopamine (DA) axon terminals (varicosities) in the neostriatum of adult rats were examined for shape, size, content, synaptic incidence, type of junction, synaptic targets, and microenvironment after electron microscopic identification ..
  34. ncbi Nonspatial and subdivision-specific working memory deficits after selective lesions of the avian prefrontal cortex
    Bettina Diekamp
    Biopsychology, Department of Psychology, Ruhr University Bochum, 44780 Bochum, Germany
    J Neurosci 22:9573-80. 2002
    ..One of these areas, the neostriatum caudolaterale (NCL) of pigeons, has been functionally compared with the mammalian prefrontal cortex (PFC) ..
  35. ncbi Protein ubiquitination in postsynaptic densities after hypoxia in rat neostriatum is blocked by hypothermia
    Francisco Capani
    Laboratorio de Citoarquitectura y Plasticidad Neuronal, Instituto de Investigaciones Cardiológicas Prof Dr Alberto C Taquini ININCA, UBA CONICET, Marcelo T de Alvear 2270, C1122AAJ, Buenos Aires, Argentina
    Exp Neurol 219:404-13. 2009
    ..The results presented here demonstrate that PSDs of the rat neostriatum are highly modified and ubiquitinated 6 months after induction of hypoxia in a model of perinatal asphyxia...
  36. ncbi 3-Hydroxyglutaric acid moderately impairs energy metabolism in brain of young rats
    A Latini
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal de Rio Grande do Sul, Anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Neuroscience 135:111-20. 2005
    ....
  37. ncbi Functional circuits mediating sensorimotor integration: quantitative comparisons of projections from rodent barrel cortex to primary motor cortex, neostriatum, superior colliculus, and the pons
    Zachary S Hoffer
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, 17033 2255, USA
    J Comp Neurol 488:82-100. 2005
    ..compared the relative density and spatial extent of the labeled projections to the primary motor (MI) cortex, neostriatum, superior colliculus, and basal pons...
  38. pmc High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats
    Emilie Lacombe
    Institut National de la Sante et de la Recherche Medicale, Unite 836, Grenoble Institut des Neurosciences, Equipe Dynamique des Réseaux Neuronaux du Mouvement, Grenoble, France
    Eur J Neurosci 26:1670-80. 2007
    ..These new neurochemical data suggest that STN-HFS interferes with L-DOPA effects, probably synergically, by stabilizing dopamine levels in the striatum and shed light on the mechanisms of STN-HFS in PD...
  39. ncbi Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Transplant 14:183-92. 2005
    ..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
  40. ncbi Abnormalities of presynaptic protein CDCrel-1 in striatum of rats reared in social isolation: relevance to neural connectivity in schizophrenia
    Alasdair M Barr
    Centre for Complex Disorders, University of British Columbia, 828 West 10th Avenue, Vancouver, BC, Canada V5Z 1L8
    Eur J Neurosci 20:303-7. 2004
    ....
  41. pmc Long-term, stable differentiation of human embryonic stem cell-derived neural precursors grafted into the adult mammalian neostriatum
    Igor Nasonkin
    Department of Pathology, Division of Neuropathology, Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Stem Cells 27:2414-26. 2009
    ..stage prior to transplantation, to survive and stably differentiate and integrate in the basal forebrain (neostriatum) of young adult nude rats over long periods of time (6 months)...
  42. pmc Distribution of GABAergic interneurons and dopaminergic cells in the functional territories of the human striatum
    Javier Bernácer
    Laboratorio de Neuromorfología Funcional, Clinica Universitaria de Navarra, Pamplona, Spain
    PLoS ONE 7:e30504. 2012
    ..This study aims to analyze the interneuron distribution in the striatal functional territories, as well as their organization regarding to the striosomal compartment...
  43. ncbi Identification of the source of the bilateral projection system from cortex to somatosensory neostriatum and an exploration of its physiological actions
    A K Wright
    University of Edinburgh Centre for Neuroscience, Department of Preclinical Veterinary Sciences, Summerhall, Edinburgh EH9 1QH, UK
    Neuroscience 103:87-96. 2001
    Microinjections of cholera toxin B subunit were made into the area of the neostriatum that receives input from the primary somatosensory barrel cortex (SI) in the rat...
  44. ncbi Focused motor stereotypies do not require enhanced activation of neurons in striosomes
    Sara B Glickstein
    Department of Psychiatry and Department of Neuroscience, Columbia University College of Physicians and Surgeons and New York State Psychiatric Institute, New York, New York 10032, USA
    J Comp Neurol 469:227-38. 2004
    ..Enhanced striosomal activation, however, is a reliable indicator of D(1)- and D(2)-receptor coactivation but not a predictor for repetitive motor behavior in general...
  45. ncbi Kv1.2-containing K+ channels regulate subthreshold excitability of striatal medium spiny neurons
    Weixing Shen
    Department of Physiology and Institute for Neuroscience, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurophysiol 91:1337-49. 2004
    ..These studies establish a clear functional role for somato-dendritic Kv1.2 channels in the regulation of state transitions and repetitive discharge in striatal medium spiny neurons...
  46. ncbi Distribution and ultrastructural localization of torsinA immunoreactivity in the human brain
    Sarah J Augood
    Neurology Service, Massachusetts General Hospital and Harvard Medical School, CNY 114 2300, 114 16th Street, Charlestown, MA 02129, USA
    Brain Res 986:12-21. 2003
    ....
  47. ncbi Increased calbindin-D28k immunoreactivity in striatal projection neurons of R6/2 Huntington's disease transgenic mice
    Z Sun
    Department of Anatomy and Neurobiology, The University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Neurobiol Dis 20:907-17. 2005
    ..The data further support the similarity of R6/2 mice to HD, and are consistent with the occurrence of an excitotoxic process in striatum in both...
  48. ncbi D1 dopamine receptors modulate deltaFosB induction in rat striatum after intermittent morphine administration
    Daniella L Muller
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad St, Philadelphia, PA 19140, USA
    J Pharmacol Exp Ther 314:148-54. 2005
    ....
  49. ncbi Cellular, subcellular, and subsynaptic distribution of AMPA-type glutamate receptor subunits in the neostriatum of the rat
    V Bernard
    University Department of Pharmacology, Oxford University, United Kingdom
    J Neurosci 17:819-33. 1997
    ..To determine the location of subunits of the AMPA subclass of glutamate receptors (GluR) in the rat neostriatum, we applied multiple immunocytochemical techniques using anti-peptide antibodies against the GluR1, GluR2/3, ..
  50. ncbi A new subdivision of mammalian neostriatum with functional implications to learning and memory
    S Y Shu
    Department of Neurobiology, Institute for Neuroscience of the First Military Medical University, Zhu Jiang Hospital, First Military Medical University, Guangzhou, China
    J Neurosci Res 58:242-53. 1999
    ..with distinctive morphological and functional attributes has been identified at the caudomedial margin of the neostriatum and surrounding the rostrolateral border of the globus pallidus in the brains of the rat, cat, monkey, and ..
  51. ncbi A new area in the human brain associated with learning and memory: immunohistochemical and functional MRI analysis
    S Y Shu
    Institute for Neuroscience of the First Military Medical University, Zhu Jiang Hospital, Guangzhou, China
    Mol Psychiatry 7:1018-22. 2002
    Previous studies identified a new brain area, the marginal division (MrD), at the caudomedial border of the neostriatum in the brain of the rat, cat and monkey...
  52. ncbi Neurogenesis in the mammalian neostriatum and nucleus accumbens: parvalbumin-immunoreactive GABAergic interneurons
    A F Sadikot
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Quebec, Canada
    J Comp Neurol 389:193-211. 1997
    ..Birthdate of PV neurons is determined in the adult neostriatum and nucleus accumbens by using a BrdU-PV double-labeling immunohistochemical technique...
  53. ncbi Afferent and efferent connections of the caudolateral neostriatum in the pigeon (Columba livia): a retro- and anterograde pathway tracing study
    S Kroner
    AE Biopsychologie, Fakultat fur Psychologie, Ruhr Universitat Bochum, Germany
    J Comp Neurol 407:228-60. 1999
    The avian caudolateral neostriatum (NCL) was first identified on the basis of its dense dopaminergic innervation...
  54. ncbi Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra
    Michael F Salvatore
    Department of Anatomy and Neurobiology, Center for Sensor Technology, and the Morris K Udall Parkinson s Disease Research Center of Excellence, University of Kentucky Medical Center, Lexington, Kentucky, USA
    J Neurochem 90:245-54. 2004
    ....
  55. ncbi The dorsocaudal neostriatum of the domestic chick: a structure serving higher associative functions
    K Braun
    Federal Institute für Neurobiology, Magdeburg, Germany
    Behav Brain Res 98:211-8. 1999
    ..Based on its anatomical features, at least one subregion of the dNC complex, the neostriatum dorsocaudale (Ndc) may be considered as the equivalent of the mammalian polysensory association cortices...
  56. ncbi Mesolimbocortical and nigrostriatal dopamine responses to salient non-reward events
    J C Horvitz
    Department of Psychology, Columbia University, New York 10027, USA
    Neuroscience 96:651-6. 2000
    ....
  57. ncbi Mutant huntingtin expression induces mitochondrial calcium handling defects in clonal striatal cells: functional consequences
    Tamara Milakovic
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 281:34785-95. 2006
    ....
  58. pmc In situ hybridization histochemical and immunohistochemical evidence that striatal projection neurons co-containing substance P and enkephalin are overrepresented in the striosomal compartment of striatum in rats
    Hong Bing Wang
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Health Science Center, 855 Monroe Ave, Memphis, TN 38163, United States
    Neurosci Lett 425:195-9. 2007
    ....
  59. ncbi Neurogenesis and stereological morphometry of calretinin-immunoreactive GABAergic interneurons of the neostriatum
    Vladimir V Rymar
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Comp Neurol 469:325-39. 2004
    ..CR-immunoreactive (-IR) neurons and BrdU-positive nuclei were labeled in the adult neostriatum by double immunohistochemistry, and the proportion of double-labeled cells was quantified...
  60. ncbi Projections from primary somatosensory cortex to the neostriatum: the role of somatotopic continuity in corticostriatal convergence
    John E Hoover
    Department of Biology, Millersville University, Millersville 17551 0302, USA
    J Neurophysiol 89:1576-87. 2003
    ..The distribution of labeled terminals and their varicosities in the neostriatum and in the thalamus were plotted and quantitatively analyzed...
  61. pmc Dysregulated information processing by medium spiny neurons in striatum of freely behaving mouse models of Huntington's disease
    Benjamin R Miller
    Program in Neuroscience, Department of Psychological and Brain Sciences, Indiana University, 1101 East 10th St, Bloomington, IN 47405, USA
    J Neurophysiol 100:2205-16. 2008
    ..Dysregulation of this processing scheme, moreover, is a key component of HD pathophysiology regardless of the severity of HD symptoms, genetic construct, and background strain of the mouse models...
  62. ncbi Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease
    Onintza Sagredo
    Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Investigación en Neuroquímica, Universidad Complutense, Madrid, Spain
    J Neurosci Res 89:1509-18. 2011
    ....
  63. ncbi FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains
    Mary Kay Lobo
    Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 90095, USA
    Nat Neurosci 9:443-52. 2006
    ..Our study provides a general approach for profiling cell type-specific gene expression in the mature mammalian brain and identifies a set of genes critical to the function and dysfunction of the striatal projection neuron circuit...
  64. pmc Amplification of dopaminergic signaling by a positive feedback loop
    A Nishi
    Department of Physiology, Kurume University School of Medicine, 67 Asahi Machi, Kurume, Fukuoka 830 0011, Japan
    Proc Natl Acad Sci U S A 97:12840-5. 2000
    ..Together, these results indicate that via positive feedback mechanisms, Cdk5 signaling and PKA signaling are mutually antagonistic...
  65. pmc Visual habit formation in monkeys with neurotoxic lesions of the ventrocaudal neostriatum
    J Fernandez-Ruiz
    Departamento de Fisiologia, Facultad de Medicina, , P.O. Box 70-250, CP 04510, Mexico
    Proc Natl Acad Sci U S A 98:4196-201. 2001
    ..The findings suggest that TE and its projection areas in the ventrocaudal neostriatum form part of a circuit that selectively mediates visual habit formation.
  66. ncbi Oscillatory entrainment of striatal neurons in freely moving rats
    Joshua D Berke
    Laboratory of Cognitive Neurobiology, Department of Psychology, Boston University, Boston, MA 02215, USA
    Neuron 43:883-96. 2004
    ..The orchestration of oscillatory activity by networks of striatal interneurons may be an important mechanism in the pathophysiology of neurological disorders such as Parkinson's disease...
  67. ncbi Neural bases of food-seeking: affect, arousal and reward in corticostriatolimbic circuits
    Bernard W Balleine
    Department of Psychology and the Brain Research Institute, University of California, Box 951563, Los Angeles, CA 90095 1563, United States
    Physiol Behav 86:717-30. 2005
    ....
  68. pmc Striatal alterations of secretogranin-1, somatostatin, prodynorphin, and cholecystokinin peptides in an experimental mouse model of Parkinson disease
    Anna Nilsson
    Department of Pharmaceutical Biosciences, Medical Mass Spectrometry, Uppsala University, SE 75123 Uppsala, Sweden
    Mol Cell Proteomics 8:1094-104. 2009
    ..This study provides further evidence that neuropeptides take part in mediating the central nervous system failure associated with Parkinson disease...
  69. ncbi Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene
    H Ishiguro
    Institute for Comprehensive Medical Science, Fujita Health University, Toyoake Aichi 470 1192, Japan
    J Neurosci Res 65:289-97. 2001
    ..The HD model mouse may therefore have advantages for investigations of molecular mechanisms underlying instability of CAG repeats...
  70. ncbi Modulation of caudate activity by action contingency
    Elizabeth M Tricomi
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    Neuron 41:281-92. 2004
    ..This finding suggests that the caudate is involved in reinforcement of action potentially leading to reward, rather than in processing reward per se...
  71. ncbi Selective impairment of prediction error signaling in human dorsolateral but not ventral striatum in Parkinson's disease patients: evidence from a model-based fMRI study
    Tom Schonberg
    Department of Psychology, Tel Aviv University Tel Aviv, Israel
    Neuroimage 49:772-81. 2010
    ..These results also provide evidence for a deficiency in PE signaling in the dorsolateral striatum of PD patients that may offer an explanation for their deficits observed in other reward learning tasks...
  72. ncbi GABAergic inhibition in the neostriatum
    Charles J Wilson
    Department of Biology, University of Texas at San Antonio, 6900 N Loop 1604 W, San Antonio, TX 78249, USA
    Prog Brain Res 160:91-110. 2007
    In the neostriatum, GABAergic inhibition arises from the action of at least two classes of inhibitory interneurons, and from recurrent collaterals of the principal cells...
  73. ncbi In-vivo quantification of dose-dependent dopamine transporter blockade in the rat striatum with small animal SPECT
    Susanne Nikolaus
    Clinic of Nuclear Medicine, University Hospital Dusseldorf, Germany
    Nucl Med Commun 28:207-13. 2007
    ..This study investigated dopamine transporter blockade in the rat striatum after treatment with various doses of methylphenidate using a high-resolution small animal SPECT ('TierSPECT') and I-FP-CIT...
  74. ncbi Cannabidiol reduced the striatal atrophy caused 3-nitropropionic acid in vivo by mechanisms independent of the activation of cannabinoid, vanilloid TRPV1 and adenosine A2A receptors
    Onintza Sagredo
    Departamento de Bioquimica y Biologia Molecular III, Universidad Complutense, 28040 Madrid, Spain
    Eur J Neurosci 26:843-51. 2007
    ..This capability seems to be based exclusively on the antioxidant properties of CBD...
  75. ncbi Electrophysiological and morphological changes in striatal spiny neurons in R6/2 Huntington's disease transgenic mice
    G J Klapstein
    Mental Retardation Research Center, University of California, Los Angeles, California 90095, USA
    J Neurophysiol 86:2667-77. 2001
    ..These physiological and morphological alterations will affect communication in the basal ganglia circuitry. Furthermore, they suggest areas to target for pharmacotherapies to alleviate and reduce the symptoms of HD...
  76. pmc Neuroprotective effects of M826, a reversible caspase-3 inhibitor, in the rat malonate model of Huntington's disease
    Sylvie Toulmond
    Department of Pharmacology, Merck Frosst Centre for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Quebec, H9H 3L1, Canada
    Br J Pharmacol 141:689-97. 2004
    ..5. These data provide in vivo proof-of-concept of the neuroprotective effects of reversible caspase-3 inhibitors in a model of malonate-induced striatal injury in the adult rat...
  77. ncbi Bilateral LMAN lesions cancel differences in HVC neuronal recruitment induced by unilateral syringeal denervation. Lateral magnocellular nucleus of the anterior neostriatum
    L Wilbrecht
    Laboratory of Animal Behavior, The Rockefeller University, New York, NY 10021, USA
    J Comp Physiol A Neuroethol Sens Neural Behav Physiol 188:909-15. 2002
    ..of their tracheosyringeal nerve, (2) bilateral lesions of the lateral magnocellular nucleus of the anterior neostriatum (LMAN), and (3) both operations. All birds were kept with an adult, singing male as a tutor until day 65...
  78. ncbi Modulation of the gene expression of N-methyl-D-aspartate receptor NR2B subunit in the rat neostriatum by a single dose of specific antisense oligodeoxynucleotide
    S C Sze
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China
    Neurochem Int 39:319-27. 2001
    ..In the neostriatum, a brain region that is associated with movement in animals, NMDA channels are known to involve in the motor ..
  79. ncbi Chronic morphine exposure and spontaneous withdrawal are associated with modifications of dopamine receptor and neuropeptide gene expression in the rat striatum
    F Georges
    Laboratoire d Histologie Embryologie, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5541, Universite Victor Segalen Bordeaux 2, France
    Eur J Neurosci 11:481-90. 1999
    ..We also show that withdrawal is associated with a down regulation of the postsynaptic D1 and D2 receptors...
  80. ncbi Postsynaptic integration of cholinergic and dopaminergic signals on medium-sized GABAergic projection neurons in the neostriatum
    L G Harsing
    Department of Neuroscience, University of Pittsburgh, PA, USA h 13768
    Brain Res Bull 45:607-13. 1998
    ..compounds were studied on electrically evoked [3H]gamma-aminobutyric acid (GABA) overflow in slices of the rat neostriatum. Slices were prepared and loaded with [3H]GABA in the presence of beta-alanine and then superfused with Krebs-..
  81. ncbi Presynaptic modulation by somatostatin in the rat neostriatum is altered in a model of parkinsonism
    Violeta G López-Huerta
    Division de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Mexico City, Mexico
    J Neurophysiol 108:1032-43. 2012
    ..It may underlie a homeostatic mechanism trying to compensate for the excitability imbalance between direct and indirect basal ganglia pathways found during parkinsonism...
  82. ncbi Effect of prenatal lead exposure on nigrostriatal neurotransmission and hydroxyl radical formation in rat neostriatum: dopaminergic-nitrergic interaction
    Przemysław Nowak
    Department of Pharmacology, Medical University of Silesia, H Jordana 38, 41 808 Zabrze, Poland
    Toxicology 246:83-9. 2008
    ..At 12 weeks after birth in vivo microdialysis of the neostriatum was employed to demonstrate that maternal Pb(2+) exposure was without effect on the baseline dopamine (DA) ..
  83. pmc The neostriatum and response selection in overt sentence production: an fMRI study
    Georgios P Argyropoulos
    Department of Neurology, University of California Irvine, Irvine, CA, USA
    Neuroimage 82:53-60. 2013
    ..We present evidence suggesting that that the putamen undertakes articulation-related aspects across tasks, while the caudate selectively supports selection processes in sentence generation. ..
  84. ncbi Binding of [123I]iodobenzamide to the rat D2 receptor after challenge with various doses of methylphenidate: an in vivo imaging study with dedicated small animal SPECT
    Susanne Nikolaus
    Clinic of Nuclear Medicine, University Hospital Dusseldorf, Moorenstr 5, 40225, Dusseldorf, Germany
    Eur J Nucl Med Mol Imaging 38:694-701. 2011
    ..The effect of various doses of methylphenidate on the binding of [(123)I]iodobenzamide ([(123)I]IBZM) to the rat D(2) receptor was assessed using small animal SPECT...
  85. pmc Dorsal striatal dopamine depletion impairs both allocentric and egocentric navigation in rats
    Amanda A Braun
    Division of Neurology, Department of Pediatrics, Cincinnati Children s Research Foundation, Cincinnati, OH 45229, USA
    Neurobiol Learn Mem 97:402-8. 2012
    ..The dopaminergic-rich neostriatum is involved in both allocentric and egocentric navigation...
  86. ncbi The role of substance P in the marginal division of the neostriatum in learning and memory is mediated through the neurokinin 1 receptor in rats
    Xue Mei Liu
    College of Biophotonics, South China Normal University, Guangzhou 510631, China
    Neurochem Res 36:1896-902. 2011
    ..The marginal division (MrD) is a pan-shaped subdivision in the caudomedial margin of the neostriatum in the mammalian brain and is known to be involved in learning and memory...
  87. ncbi Motor and cognitive functions of the neostriatum during bilateral blockade of its dopamine receptors
    K B Shapovalova
    I P Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St Petersburg, Russia
    Neurosci Behav Physiol 38:71-9. 2008
    ..At the same time, bilateral microinjection of SCH23390 into the rat neostriatum at doses of 0.004-1...
  88. pmc Soluble cytokine receptors (sIL-2Rα, sIL-2Rβ) induce subunit-specific behavioral responses and accumulate in the cerebral cortex and basal forebrain
    Steven S Zalcman
    Department of Psychiatry, UMDNJ New Jersey Medical School, Newark, New Jersey, USA
    PLoS ONE 7:e36316. 2012
    ..These findings suggest that sIL-2Rs act as novel immune-to- brain messengers and raise the possibility that they contribute to the disease process in psychiatric disorders in which marked increases in these receptors have been reported...
  89. ncbi Differential changes of synaptic transmission in spiny neurons of rat neostriatum following transient forebrain ischemia
    M Gajendiran
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, 635 Barnhill Drive, MS 507, Indianapolis, IN 46202, USA
    Neuroscience 105:139-52. 2001
    Spiny neurons in neostriatum are vulnerable to cerebral ischemia...
  90. ncbi Serotonergic heterotypic sprouting in the unilaterally dopamine-depleted mouse neostriatum
    I Yamazoe
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Dev Neurosci 23:78-83. 2001
    ..The majority of the TH-immunoreactive structures disappeared from the substantia nigra and neostriatum on the 6-OHDA lesioned side...
  91. ncbi Chronic systemic pesticide exposure reproduces features of Parkinson's disease
    R Betarbet
    Department of Neurology, Emory University, 1639 Pierce Drive, WMB 6000, Atlanta, Georgia 30322, USA
    Nat Neurosci 3:1301-6. 2000
    ..These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD...
  92. ncbi SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats
    J Wardas
    Department of Neuropsychopharmacology, Institute of Pharmacology, Polish Academy of Sciences, Pl 31 343 Krakow, Poland
    Synapse 41:160-71. 2001
    ..The ability of SCH 58261 to diminish the parkinsonian-like muscle rigidity and to potentiate the effect of L-DOPA in this model seems to indicate a therapeutic value of this compound in the treatment of Parkinson's disease...
  93. ncbi Differential messenger RNA expression of complexins in mouse brain
    Whitney Freeman
    Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK
    Brain Res Bull 63:33-44. 2004
    ....
  94. ncbi Striatal potassium channel dysfunction in Huntington's disease transgenic mice
    Marjorie A Ariano
    Mental Retardation Research Center, NPI Room 58 258, 760 Westwood Plaza, University of California, Los Angeles, CA 90095, USA
    J Neurophysiol 93:2565-74. 2005
    ..Attenuation in K+ conductances and channel subunit expression contribute to altered electrophysiological properties of MSNs and may partially account for selective cellular vulnerability in the striatum...
  95. ncbi Integration of information from both eyes by single neurons of nucleus rotundus, ectostriatum and lateral neostriatum in the zebra finch (Taeniopygia guttata castanotis Gould)
    A Schmidt
    Lehrstuhl Verhaltensforschung, , Postfach 10 01 31, D-33501 Bielefeld, Germany
    Brain Res 923:20-31. 2001
    ..The ectostriatum itself projects to the overlying lateral neostriatum, an area which serves an important role in sexual imprinting...
  96. ncbi TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia
    Haixin Zhang
    Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, 5 Zaifu cho, Hirosaki, 036 8562, Japan
    Acta Neuropathol 115:115-22. 2008
    ..We immunohistochemically examined the neostriatum from 14 cases of classic ALS (cALS), six cases of ALS with dementia (ALS-D), and 20 control subjects...
  97. ncbi 6-hydroxydopamine lesions in the rat neostriatum impair sequential learning in a serial reaction time task
    Moritz Thede Eckart
    Department of Psychology, Philipps University of Marburg, Gutenbergstrasse18, 35032 Marburg, Germany
    Neurotox Res 17:287-98. 2010
    ..e. residual levels around 34-56% of controls), especially in the medial neostriatum. These lesions did not lead to general motor deficits in a catalepsy task, but moderate deficits in locomotion ..
  98. ncbi Interactions among memory-related centers in the brain
    Si Yun Shu
    Institute for Neuroscience, First Military Medical University, Zhu Jiang Hospital, Guangzhou, People s Republic of China
    J Neurosci Res 71:609-16. 2003
    ..division (MrD) is a pan-shaped structure consisting of spindle-shaped neurons at the caudal margin of the neostriatum in the mammalian brain...
  99. pmc Enkephalin surges in dorsal neostriatum as a signal to eat
    Alexandra G DiFeliceantonio
    Department of Psychology, University of Michigan, Ann Arbor, MI 48109, USA
    Curr Biol 22:1918-24. 2012
    ..Here, we provide evidence that enkephalin surges in an anteromedial quadrant of dorsal neostriatum contribute to generating intense consumption of palatable food...
  100. ncbi Striatal dopaminergic stimulation produces c-Fos expression in the PPT and an increase in wakefulness
    Juan Mena-Segovia
    Department of Behavioral and Cognitive Neurobiology, Instituto de Neurobiologia, Campus UNAM Juriquilla, 76230, Queretaro, Qro 76230, Mexico
    Brain Res 986:30-8. 2003
    ..They also suggest that the striatum participates in non-specific cortical activation probably as a result of its relationship with the PPT...
  101. ncbi Differential expression of GABA(B)R1 and GABA(B)R2 receptor immunoreactivity in neurochemically identified neurons of the rat neostriatum
    T K Ng
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China
    J Comp Neurol 433:458-70. 2001
    Gamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the neostriatum. Functions of GABA are known to mediate GABA(A) and GABA(B) receptors...

Research Grants63

  1. Development of a Human Hydrolase to Treat Cocaine Abuse and Overdose: Rat Models
    WILLIAM STEPHEN BRIMIJOIN; Fiscal Year: 2011
    ..Extensive pharmacokinetics and mechanistic studies of dopamine transients in the neostriatum of cocaine-challenged rats will test the hypothesis that recovery from seizures reflects the creation of steep ..
  2. A Tonically Active Network in the Neostriatum
    Charles J Wilson; Fiscal Year: 2013
    ..These experiments will reveal mechanisms promoting synchronization that may be points of action of dopaminergic depletion and possible targets for future anti-parkinsonian therapies. ..
  3. Transcriptional regulation of aging in the adult neural stem cell niche
    HOOMAN TROY GHASHGHAEI; Fiscal Year: 2013
    ..The adult SCN consists of astrocytes and ependymal cells that line the ventricular surface of the neostriatum. Both these cell types are derived from an embryonic SCN in the lateral ganglion eminences (LGE)...
  4. Huntington's Disease and Neurogenesis
    Lisa M Ellerby; Fiscal Year: 2012
    ..FGF-2 also induced recruitment of new neurons from the SVZ into the neostriatum and cerebral cortex of HD transgenic R6/2 mice...
  5. Amphetamine sensitization in a model of schizophrenia
    Russell W Brown; Fiscal Year: 2010
    ..acute injection of amphetamine to D2-primed rats produced a 4-fold increase in dopamine microdialysate in the neostriatum compared to animals non-D2-primed rats neonatally treated with saline...
  6. Functional Striatal Microcircuits in vivo and in vitro
    James M Tepper; Fiscal Year: 2013
    Project Summary/Abstract The neostriatum is the main input structure of the basal ganglia, a system that is crucial not only for voluntary motor control, but also for reinforcement-mediated learning and higher cognitive functions...
  7. Endogenous GABAergic Activity
    Istvan Mody; Fiscal Year: 2013
    ..extremely excitable nature of the CA3 region and its relevance to epilepsy, and the high susceptibility of the neostriatum to dysfunction and degeneration, these experiments will address central issues related to the pathologies and ..
  8. Neostriatum in Learning and Memory
    Emad N Eskandar; Fiscal Year: 2013
    ..These results will be extremely important for optimizing and generating treatments for a broad range of neurological and psychiatric disorders. ..
  9. A Novel Ionic Mechanism of Ischemic Neuronal Injury
    Ping Deng; Fiscal Year: 2012
    ..Transient cerebral ischemia causes selective neuronal death in certain brain regions, including the neostriatum, which is fundamental to sensorimotor learning, movement control and cognitive functions...
  10. Ethanol Effects on Neostriatal Function
    Henry Yin; Fiscal Year: 2010
    ..mechanisms that lead to alcohol addiction, by assessing the effects of ethanol on long-term plasticity in the neostriatum and on striatum-dependent forms of learning and memory...
  11. Optogenetic Analysis of Neostriatal Circuits Engaged by Cholinergic Interneurons
    James M Tepper; Fiscal Year: 2013
    ..These experiments will describe the functional organization of a powerful novel circuit mechanism of the neostriatum and therefore will significantly advance the understanding of the functioning of the basal ganglia...
  12. GLIA AND GLYCOCONJUGATES IN THE NEOSTRIATUM
    Dennis Steindler; Fiscal Year: 1999
    ..In the developing caudate-putamen (neostriatum), these boundaries surround different compartments of a neostriatal mosaic, the patch and matrix, and most ..
  13. NEURONAL PATHWAYS OF THE BASAL GANGLIA
    Hitoshi Kita; Fiscal Year: 2000
    ..nuclei, the entopeduncular nucleus and the substantia nigra pars reticulata, through two different nuclei, the neostriatum and the subthalamic nucleus...
  14. NEURON TRANSPLANT THERAPY: A MODEL OF PARKINSONISM
    MARK DUBACH; Fiscal Year: 1990
    ..that primates differ from rodents in neuroanatomey, neurochemistry, and behavior associated with the neostriatum, insufficient studies have been conducted in primates to establish effective, safe and reliable techniques...
  15. NEOSTRIATAL CHOLINERGIC INTERNEURONS FIRING PATTERNS
    Charles J Wilson; Fiscal Year: 2010
    ..Despite the explosion of information on the pharmacology of acetylcholine in the neostriatum, physiological information has been difficult to obtain due to the rarity of cholinergic interneurons compared ..
  16. DOPAMINE IN NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
    Francis Filloux; Fiscal Year: 1992
    The hypothesis of this proposal for a CIA is that excessive dopamine release in the neostriatum may contribute to the cerebral damage incurred in neonatal hypoxic-ischemic encephalopathy...
  17. FUNCTIONAL ORGANIZATION OF THE CORTICOSTRIATAL PATHWAY
    Charles Wilson; Fiscal Year: 1990
    ..Paired injections in neostriatum and each of several other major targets of motor and premotor cortex will also be performed...
  18. MECHANISM OF ACTION OF DRUGS OF ABUSE--AMPHETAMINE
    Ronald Kuczenski; Fiscal Year: 2004
    ..Excitability measurements will assess possible presynaptic changes in the glutamatergic afferents to the neostriatum, nucleus accumbens and ventral tegmental area...
  19. REGION SPECIFIC PHOSPHOPROTEINS IN THE BASAL GANGLIA
    Paul Greengard; Fiscal Year: 2004
    There are major medical reasons for understanding the nature of dopaminergic neurotransmission in the neostriatum. Parkinson's disease,, Huntington's chorea, schizophrenia and attention deficit hyperactivity disorder all reflect ..
  20. NEUROBIOLOGY OF SENSORY ACQUISITION
    Patrice Adret; Fiscal Year: 2001
    ..1) the ascending auditory pathways; (2) several higher- order auditory areas including the caudomedial neostriatum (Ncm); (3) the anterior forebrain pathway (AFP) of the song system, and (4) the motor control pathway of the ..
  21. DOPAMINE NERVES SUPRESS HYDROXYL RADICAL FORMATION IN NE
    RICHARD KOSTRZEWA; Fiscal Year: 1999
    ..Counter to this view of DA as an autotoxin, they found that basal OH in neostriatum was low when DA innervation of neostriatum was intact, but that OH increased several fold if DA innervation ..
  22. EXCITATORY SYNAPTIC TRANSMISSION IN NEOSTRIATUM
    David Lovinger; Fiscal Year: 2000
    ..of the way in which glutamatergic and dopaminergic synaptic transmission contribute to the function of the neostriatum. Previous experiments have demonstrated roles for both ionotropic and metabotropic glutamate receptors in ..
  23. DEVELOPMENT OF A 3-D CELL-CENTERED NEURONAL DATABASE
    Maryann Martone; Fiscal Year: 2007
    ..research on the structure of cells in the cerebella cortex, a highly ordered cytoarchitectural region, and the neostriatum, an area of exceeding neurochemical complexity with little cytoarchitectural differentiation...
  24. ALCOHOL REWARD AND BRAIN DOPAMINE--PHARMACO-MODULATIONS
    ELIOT GARDNER; Fiscal Year: 1993
    ..vivo voltammetry) in three reward-relevant DA forebrain loci - nucleus accumbens, medial prefrontal cortex, and neostriatum; 2) study the effect of strain differences (alcohol-preferring Lewis rats versus non-preferring F344 rats) on ..
  25. CELLULAR DOPAMINE RECEPTOR COINCIDENCE
    MARJORIE ARIANO; Fiscal Year: 1993
    ..The proposed experiments will examine the intact brain, and focus on the neostriatum (CN), the substantia nigra (SN), the ventral tegmental area (VTA), and the prefrontal cortex (Pfx), since these ..
  26. Ephrins and Repeated Cocaine
    Robert Pierce; Fiscal Year: 2006
    ..the influence of acute and repeated injections of cocaine on the expression of EphB1 and ephrin-B2 in the neostriatum, core and shell of the nucleus accumbens, substantia nigra and/or ventral termental area...
  27. GROWTH FACTORS IN BRAIN PLASTICITY AND DEVELOPMENT
    Harley Kornblum; Fiscal Year: 2000
    ..to determine if transforming growth factor alpha (TGFalpha) plays an important role in the development of the neostriatum and the formation of its connections with the ventral midbrain and neocortex...
  28. NOVEL MODES OF ACTION OF ABUSED DRUGS
    PHILIP GROVES; Fiscal Year: 2001
    ..methods and tomographic three-dimensional reconstruction will further elucidate the circuitry of the cortex and neostriatum. The applicant will also determine whether dopaminergic inputs onto spines are associated with inputs from ..
  29. SENSORIMOTOR INTEGRATION IN NEOSTRIATUM
    Mahlon Delong; Fiscal Year: 1992
    The general goals are to examine the relationships between structure and function in the primate neostriatum and to provide a better understanding of the nature and mechanisms of sensorimotor integration in the putamen...
  30. NERVE GROWTH FACTOR ACTION ON ADULT CNS NEURONS IN VIVO
    SILVIO VARON; Fiscal Year: 1993
    ..NGF treatments cause an increase in body size and ChAT immunostaining in cholinergic neurons of an undamaged neostriatum. This proposal has two major aims...
  31. REGULATION OF NEURAL GENE EXPRESSION
    Anthony Campagnoni; Fiscal Year: 1993
    ..The major objective of Project 1 will be to identify genes of importance in the functioning of the neostriatum, including putative genes that might involve Huntington's Disease...
  32. Cellular and Synaptic Physiology of Auditory Processing
    CLAUDIO MELLO; Fiscal Year: 2007
    ..the auditory processing of song in songbirds, more specifically the circuitry organization of the caudomedial neostriatum (NCM) in the zebra finch...
  33. DETERMINANTS OF ADULT NEUROGENESIS AND MIGRATION I
    Steven Goldman; Fiscal Year: 2000
    ..hormones act to recruit new neurons into the adult brain, using the higher vocal center (HVc) and the adjacent neostriatum in adult avian (canary, zebra finch) as a model...
  34. Neurotrophins and Cocaine-Induced Neuronal Plasticity
    Guohua Yue; Fiscal Year: 2006
    ..to assess the influence of acute and repeated injections of cocaine on the expression of NT-3 and BDNF in the neostriatum, core and shell of the nucleus accumbens; and ii) to assess the effect of antisense oligonucleotide suppression ..
  35. Dopamine modulation of the neostriatal feedback circuitry
    Tibor Koos; Fiscal Year: 2010
    ..neurons suggests a critical role in the regulation of the spatial and temporal pattern of activity of the neostriatum, and in particular in the control of the balance of activity between the functionally segregated output ..
  36. INTERNEURONAL MICROCIRCUITRY OF THE RAT NEOSTRIATUM
    JAMES TEPPER; Fiscal Year: 1999
    ..The neostriatum, the largest nucleus of the basal ganglia has a central role in controlling the functioning of the basal ..
  37. NEUROBIOLOGY OF ADAPTATION TO STRESS AND INJURY
    Michael Zigmond; Fiscal Year: 2000
    ..designed to determine (l) the extent to which function is preserved after damage to the dopaminergic input to neostriatum, (2) the generality of our model for compensations after partial lesions, looking at other conditions of ..
  38. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2002
    ..goal is to characterize the molecular and cellular mechanisms of dopaminergic and cholinergic signaling in the neostriatum. The overarching goal of this FIRCA proposal is to further these aims by incorporating patch clamp recording ..
  39. The Role of Calcyon in Synaptic Integration
    Clare Bergson; Fiscal Year: 2004
    ..subtype, in particular, modulates glutamate-induced neuronal excitability in frontal cortex, hippocampus and neostriatum. Little is known about molecular mechanism(s) by which D1 receptor signaling modulates excitatory transmission...
  40. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Zao Xu will use TEM to investigate the nature of cell death, e.g. necrosis or apoptosis, in neostriatum of the rat after transient global schemia. Dr...
  41. BEHAVIORAL FUNCTIONS OF NEOSTRIATAL COMPARTMENTS
    Lawrence Ryan; Fiscal Year: 1991
    ..The neostriatum is an important subcortical structure involved in the generation of motor behavior...
  42. GENE REGULATION IN AUDITORY LEARNING
    CLAUDIO MELLO; Fiscal Year: 2000
    ..e., ZENK and c-jun) are induced in a region of the forebrain known as the caudal neostriatum (NCM)...
  43. MATURATION OF MONKEY VISUAL AND BASAL GANGLIA SYSTEMS
    Tauba Pasik; Fiscal Year: 1980
    ..structures to be investigated will be the lateral geniculate nucleus pars dorsalis and pars ventralis, the neostriatum and the pallidum of rhesus monkeys at 0 (newborn), 1, 2, 4 and 8 weeks of age...
  44. MECHANISMS OF RECOVERY OF BEHAVIORAL FUNCTION
    LOUIS MISANTONE; Fiscal Year: 1980
    ..The nigral and frontal cortical (FC) projections to the neostriatum, and the role this triad plays in regulating the rat's ingestive behavior and body weight comprise the model ..
  45. Neuroprotection via XIAP gene therapy in Huntington's disease
    Michael Kaplitt; Fiscal Year: 2007
    ..to deliver the gene encoding XIAP to the major site of neurodegeneration in Huntington's disease, the neostriatum. The proposed experiments in genetic mouse models of Huntington's disease arise from the observations that ..
  46. DOPAMINERGIC MODULATION OF AGING STRIATUM
    Michael Levine; Fiscal Year: 1990
    ..We will focus on a major part of the basal ganglia, the neostriatum, because this ares of the brain is in- volved in pathological conditions associated with aging...
  47. DEVELOPMENT OF A 3D CELL-CENTERED NEURONAL DATABASE
    Mark Ellisman; Fiscal Year: 2001
    ..Initial studies will concentrate on the cerebellum with plans to study other brain regions later (e.g., neostriatum, hippocampus, olfactory bulb, cortex)...
  48. Is it Memory or Is It Death, Caspase-3 and Memory
    GRAHAM HUESMANN; Fiscal Year: 2006
    ..Working Hypothesis: Playback of novel songs will trigger a transient activation of caspase-3, at subcellular sites supporting the storage of new song memories, in the zebra finch caudomedial neostriatum (NCM, auditory
  49. Functional Organization of Somatosensory Cortex
    KEVIN ALLOWAY; Fiscal Year: 2007
    ..To address this issue, conditional cross-correlation analysis will be used to quantify the impact of synchronized activity in SI on the probability of neuronal responsiveness in corresponding parts of the MI whisker representation. ..
  50. Somatosensory Cortical Influences on Subcortical Processing
    KEVIN DOUGLAS ALLOWAY; Fiscal Year: 2010
    ..half of this project we will record multiple neurons in somatosensory cortex simultaneously with neurons in the neostriatum and the pons...
  51. Somatosensory Cortical Influences on Subcortical Processing
    KEVIN ALLOWAY; Fiscal Year: 2007
    ..system as a model system, we plan to analyze and compare the integration of cortical inputs in both the neostriatum and the pons...
  52. Dopamine D4 Receptor in Sustained Attention
    Kehong Zhang; Fiscal Year: 2003
    ..The findings may also provide a pharmacological basis for innovative treatment for ADHD to replace stimulant therapy. ..
  53. MESOLIMBIC DOPAMINE D3 RECEPTOR AND PARKINSON'S DISEASE
    Jeffrey Joyce; Fiscal Year: 2002
    ..This will further elucidate the pathology of DAergic substrates of specific clinical symptoms in PD and provide a broader basis for developing effective treatment strategies based on specific DA receptors. ..
  54. NEURAL MECHANISMS OF VOCAL LEARNING
    SARAH BOTTJER; Fiscal Year: 2009
    ..abstract_text> ..
  55. NEOSTRIATAL CHOLINERGIC INTERNEURONS FIRING PATTERNS
    Charles Wilson; Fiscal Year: 2001
    ..Despite the explosion of information on the pharmacology of acetylcholine in the neostriatum, physiological information has been difficult to obtain due to the relative rarity of cholinergic interneurons ..
  56. Lateral Hypothalamus, Dopamine and Ingestive Behavior
    David Wirtshafter; Fiscal Year: 2007
    ..Gaining an understanding of these systems is a prerequisite for the rational development of novel treatments for disturbances of ingestion, such as occur in obesity, bulemia and cahchexia. [unreadable] [unreadable] [unreadable]..
  57. Neuropeptides and the Mammalian Circadian System
    Christopher Colwell; Fiscal Year: 2007
    ..In addition, transgenic mice lacking PACAP and VIP will be analyzed with behavioral and anatomical tools. These newly developed mice are likely to prove a useful tool for circadian rhythms research. ..
  58. NEURONAL ORGANIZATION OF BASAL GANGLIA
    Charles Wilson; Fiscal Year: 2003
    DESCRIPTION: (Adapted from the Investigator's Abstract) The neostriatum is the target of most afferent inputs to the basal ganglia, including the enormous projection from the cerebral cortex and the important modulatory dopamine input ..
  59. Ethanol Driven Neuroadaptation of Cholinergic Interneur
    ADRIANA ALCANTARA; Fiscal Year: 2005
    ..abstract_text> ..
  60. REGULATION OF THE MAMMALIAN CIRCADIAN SYSTEM
    Christopher Colwell; Fiscal Year: 2002
    ..Finally, the proposed work will determine whether a model developed to explain synchronization of molluscan circadian oscillators can be applied to the mammalian SCN. ..