corpus striatum

Summary

Summary: Striped gray and white matter consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the thalamus in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The white matter is the internal capsule.

Top Publications

  1. ncbi Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    M Difiglia
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:1990-3. 1997
  2. ncbi Brain dopamine and obesity
    G J Wang
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    Lancet 357:354-7. 2001
  3. pmc Modulation of striatal projection systems by dopamine
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 34:441-66. 2011
  4. ncbi Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
  5. ncbi The role of the dorsal striatum in reward and decision-making
    Bernard W Balleine
    Department of Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 27:8161-5. 2007
  6. ncbi D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    C R Gerfen
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892
    Science 250:1429-32. 1990
  7. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
  8. ncbi Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
    S N Haber
    Department of Neurobiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurosci 20:2369-82. 2000
  9. ncbi Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    Libin Cui
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129 USA
    Cell 127:59-69. 2006
  10. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005

Detail Information

Publications291 found, 100 shown here

  1. ncbi Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain
    M Difiglia
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Science 277:1990-3. 1997
    ..Ubiquitin was also found in NIIs and DNs, which suggests that abnormal huntingtin is targeted for proteolysis but is resistant to removal. The aggregation of mutant huntingtin may be part of the pathogenic mechanism in HD...
  2. ncbi Brain dopamine and obesity
    G J Wang
    Department of Medicine, Brookhaven National Laboratory, Upton, New York 11973, USA
    Lancet 357:354-7. 2001
    ..To test the hypothesis that obese individuals have abnormalities in brain dopamine activity we measured the availability of dopamine D2 receptors in brain...
  3. pmc Modulation of striatal projection systems by dopamine
    Charles R Gerfen
    Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 34:441-66. 2011
    ..The contrast provided by these studies has provided new insights into how the striatum responds to fluctuations in DA signaling and how diseases that alter this signaling change striatal function...
  4. ncbi Blockade of microglial activation is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson disease
    D C Wu
    Department of Neurology, Columbia University, New York, New York 10032, USA
    J Neurosci 22:1763-71. 2002
    ..This study demonstrates that microglial-related inflammatory events play a significant role in the MPTP neurotoxic process and suggests that minocycline may be a valuable neuroprotective agent for the treatment of PD...
  5. ncbi The role of the dorsal striatum in reward and decision-making
    Bernard W Balleine
    Department of Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, California 90095 1563, USA
    J Neurosci 27:8161-5. 2007
    ..We review key evidence from recent studies in rodent, nonhuman primate, and human subjects...
  6. ncbi D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    C R Gerfen
    Laboratory of Cell Biology, National Institute of Mental Health, Bethesda, MD 20892
    Science 250:1429-32. 1990
    ..Thus, the differential effects of dopamine on striatonigral and striatopallidal neurons are mediated by their specific expression of D1 and D2 dopamine receptor subtypes, respectively...
  7. ncbi Neural mechanisms of addiction: the role of reward-related learning and memory
    Steven E Hyman
    Office of the Provost, Harvard University, Cambridge, Massachusetts 02138, USA
    Annu Rev Neurosci 29:565-98. 2006
    ..Here we review progress in identifying candidate mechanisms of addiction...
  8. ncbi Striatonigrostriatal pathways in primates form an ascending spiral from the shell to the dorsolateral striatum
    S N Haber
    Department of Neurobiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurosci 20:2369-82. 2000
    ..This anatomical arrangement creates a hierarchy of information flow and provides an anatomical basis for the limbic/cognitive/motor interface via the ventral midbrain...
  9. ncbi Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
    Libin Cui
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, MassGeneral Institute for Neurodegeneration, Charlestown, MA 02129 USA
    Cell 127:59-69. 2006
    ..These studies suggest a key role for PGC-1alpha in the control of energy metabolism in the early stages of HD pathogenesis...
  10. ncbi An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior
    Jean Martin Beaulieu
    Department of Cell Biology, Center for Models of Human Disease, Institute for Genome Sciences and Policy, Duke University Medical Center, Durham, North Carolina 27710, USA
    Cell 122:261-73. 2005
    ....
  11. ncbi Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease
    C Zuccato
    Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
    Science 293:493-8. 2001
    ..This leads to insufficient neurotrophic support for striatal neurons, which then die. Restoring wild-type huntingtin activity and increasing BDNF production may be therapeutic approaches for treating HD...
  12. ncbi D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons
    D James Surmeier
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA lt j
    Trends Neurosci 30:228-35. 2007
    ..These studies have also shown that long-term alterations in dopamine signaling produce profound and cell-type-specific reshaping of corticostriatal connectivity and function...
  13. pmc Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors
    Michael J Higley
    Howard Hughes Medical Institute, Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA
    Nat Neurosci 13:958-66. 2010
    ..These findings reveal that dopamine regulates spine Ca2+ by multiple pathways and that competitive modulation of PKA controls NMDAR-mediated Ca2+ signaling in the striatum...
  14. ncbi Increased synaptic dopamine function in associative regions of the striatum in schizophrenia
    Lawrence S Kegeles
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Arch Gen Psychiatry 67:231-9. 2010
    ....
  15. ncbi Imaging human mesolimbic dopamine transmission with positron emission tomography. Part II: amphetamine-induced dopamine release in the functional subdivisions of the striatum
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, New York, NY 10032, USA
    J Cereb Blood Flow Metab 23:285-300. 2003
    ....
  16. pmc Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement
    Jeffrey W Dalley
    Behavioral and Clinical Neuroscience Institute, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK
    Science 315:1267-70. 2007
    ..These data demonstrate that trait impulsivity predicts cocaine reinforcement and that D2 receptor dysfunction in abstinent cocaine addicts may, in part, be determined by premorbid influences...
  17. ncbi Diffusion tensor fiber tracking shows distinct corticostriatal circuits in humans
    Stephane Lehericy
    Center for Magnetic Resonance Research, University of Minnesota Medical School, Minneapolis, MN, USA
    Ann Neurol 55:522-9. 2004
    ..These results provide the first direct demonstration of distinct corticostriatal connections in humans...
  18. ncbi The role of the dorsomedial striatum in instrumental conditioning
    Henry H Yin
    Department of Psychology and Brain Research Institute, University of California, Los Angeles, Box 951563, Los Angeles, CA 90095 1563, USA
    Eur J Neurosci 22:513-23. 2005
    ..Taken together, these results suggest that the posterior region of the DMS is a crucial neural substrate for the acquisition and expression of action-outcome associations in instrumental conditioning...
  19. ncbi Putting a spin on the dorsal-ventral divide of the striatum
    Pieter Voorn
    Department of Anatomy, Research Institute Neurosciences, VU University Medical Center, MF G 102, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Trends Neurosci 27:468-74. 2004
    ..Therefore, this review presents a synthesis between the dorsal-ventral distinction and the more mediolateral-oriented functional striatal gradient...
  20. ncbi Cocaine seeking habits depend upon dopamine-dependent serial connectivity linking the ventral with the dorsal striatum
    David Belin
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, UK
    Neuron 57:432-41. 2008
    ....
  21. pmc Developmental regulation and neuroprotective effects of striatal tonic GABAA currents
    V Santhakumar
    Departments of Neurology and Physiology, David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
    Neuroscience 167:644-55. 2010
    ..Our data are consistent with a role for tonic inhibition mediated by GABA(A)R delta subunits in neuroprotection against excitotoxic insults in the adult striatum...
  22. ncbi Modeling Parkinson's disease in rats: an evaluation of 6-OHDA lesions of the nigrostriatal pathway
    Ronald Deumens
    Department of Psychiatry and Neuropsychology, Brain and Behavior Institute, 6200 MD Maastricht, The Netherlands
    Exp Neurol 175:303-17. 2002
    ..The choice of the behavioral parameters determines the use of unilateral or bilateral lesions, although it is obvious that the bilateral model mimics the human situation more closely...
  23. pmc Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicity
    Srinivasa Subramaniam
    Solomon H Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Science 324:1327-30. 2009
    ..Yet, HD neuropathology is largely restricted to the corpus striatum. We report that the small guanine nucleotide-binding protein Rhes, which is localized very selectively to the ..
  24. pmc Differential regulation of motor control and response to dopaminergic drugs by D1R and D2R neurons in distinct dorsal striatum subregions
    Pierre F Durieux
    Laboratory of Neurophysiology, School of Medicine, Universite Libre de Bruxelles, ULB, Brussels, Belgium
    EMBO J 31:640-53. 2012
    ..Altogether, these data provide direct experimental evidence for cell-specific topographic functional organization of the dorsal striatum...
  25. ncbi Reduced striatal dopamine D2 receptors in people with Internet addiction
    Sang Hee Kim
    Department of Brain and Cognitive Engineering, Korea University, Seoul, Korea
    Neuroreport 22:407-11. 2011
    ..This finding contributes to the understanding of neurobiological mechanism of Internet addiction...
  26. ncbi Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats
    Liliana B Menalled
    Department of Neurology, University of California at Los Angeles, Los Angeles, California 90095, USA
    J Comp Neurol 465:11-26. 2003
    ..Because of their early behavioral anomalies and regionally specific pathology, these mice provide a powerful tool with which to evaluate the effectiveness of new therapies and to study the mechanisms involved in the neuropathology of HD...
  27. pmc Dopaminergic network differences in human impulsivity
    Joshua W Buckholtz
    Department of Psychology, Vanderbilt University, Nashville, TN 37240, USA
    Science 329:532. 2010
    ..Path analysis confirmed that the impact of decreased midbrain D2/D3 autoreceptor availability on trait impulsivity is mediated in part through its effect on stimulated striatal DA release...
  28. ncbi Pten ablation in adult dopaminergic neurons is neuroprotective in Parkinson's disease models
    Andrii Domanskyi
    Division of Molecular Biology of the Cell I, German Cancer Research Center, Heidelberg, Germany
    FASEB J 25:2898-910. 2011
    ..Inhibition of Pten-dependent functions in adult DA neurons may represent a promising PD therapy...
  29. pmc Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study
    Eric Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    J Abnorm Psychol 117:924-35. 2008
    ....
  30. ncbi A dopaminergic axon lattice in the striatum and its relationship with cortical and thalamic terminals
    Jonathan Moss
    Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    J Neurosci 28:11221-30. 2008
    ..We conclude that (1) thalamostriatal synapses are in a position to be influenced by released dopamine to a similar degree as corticostriatal synapses are and (2) these associations arise from a nonselective dopaminergic axon lattice...
  31. ncbi Single nigrostriatal dopaminergic neurons form widely spread and highly dense axonal arborizations in the neostriatum
    Wakoto Matsuda
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    J Neurosci 29:444-53. 2009
    ..Thus, these results would also contribute to understanding the clinicopathology of Parkinson's disease and related syndromes...
  32. ncbi Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning
    Suzanne N Haber
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, New York 14642, USA
    J Neurosci 26:8368-76. 2006
    ..Furthermore, areas of convergence may be particularly sensitive to dopamine modulation during decision making and habit formation...
  33. ncbi Involvement of the dorsal striatum in cue-controlled cocaine seeking
    Louk J M J Vanderschuren
    Department of Experimental Psychology, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 25:8665-70. 2005
    ..In addition, given the importance of the dorsal striatum in stimulus-response habit learning, these data suggest that the habitual or compulsive quality of persistent drug seeking depends on dorsal striatal mechanisms...
  34. pmc Increased striatal dopamine release in Parkinsonian patients with pathological gambling: a [11C] raclopride PET study
    T D L Steeves
    Movement Disorders Centre, Toronto Western Hospital, UHN, Ontario, Canada
    Brain 132:1376-85. 2009
    ..The emergence of pathological gambling in a number of Parkinson's disease patients may provide a model into the pathophysiology of this disorder...
  35. ncbi Abnormal Ca2+-calmodulin-dependent protein kinase II function mediates synaptic and motor deficits in experimental parkinsonism
    Barbara Picconi
    Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, 00133 Rome, Italy
    J Neurosci 24:5283-91. 2004
    ..Normalization of CaMKII activity may be an important underlying mechanism of the therapeutic action of L-DOPA in PD...
  36. ncbi Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum
    Toru Yamashita
    Bridgestone Laboratory of Developmental and Regenerative Neurobiology, Keio University School of Medicine, Shinanomachi, Tokyo 160 8582, Japan
    J Neurosci 26:6627-36. 2006
    ..These results highlight the role of the SVZ in neuronal regeneration after a stroke and its potential as an important therapeutic target for various neurological disorders...
  37. ncbi Adult bone marrow stromal cells differentiate into neural cells in vitro
    J Sanchez-Ramos
    Department of Neurology, University of South Florida, Tampa, USA
    Exp Neurol 164:247-56. 2000
    ..When labeled human or mouse BMSC were cultured with rat fetal mesencephalic or striatal cells, a small proportion of BMSC-derived cells differentiated into neuron-like cells expressing NeuN and glial cells expressing GFAP...
  38. ncbi Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons
    Zhongfeng Wang
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    Neuron 50:443-52. 2006
    ..In addition to reconciling discordant tracts of the striatal literature, these findings point to cholinergic interneurons as key mediators of dopamine-dependent striatal plasticity and learning...
  39. pmc Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
    MALU G TANSEY
    Department of Physiology, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Exp Neurol 208:1-25. 2007
    ....
  40. pmc Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory
    Ying Zhang
    Program in Pharmacogenomics, Department of Pharmacology, Ohio State University, Columbus, OH 43210, USA
    Proc Natl Acad Sci U S A 104:20552-7. 2007
    ..Our results identify regulatory DRD2 polymorphisms that modify mRNA expression and splicing and working memory pathways...
  41. pmc Low dopamine striatal D2 receptors are associated with prefrontal metabolism in obese subjects: possible contributing factors
    Nora D Volkow
    National Institute on Drug Abuse, Bethesda MD 20892, USA
    Neuroimage 42:1537-43. 2008
    ..The association between striatal D2 receptors and metabolism in somatosensory cortices (regions that process palatability) could underlie one of the mechanisms through which dopamine regulates the reinforcing properties of food...
  42. pmc Relation between obesity and blunted striatal response to food is moderated by TaqIA A1 allele
    E Stice
    Oregon Research Institute, 1715 Franklin Boulevard, Eugene, OR 97403, USA
    Science 322:449-52. 2008
    ....
  43. pmc Striatal dopamine d2/d3 receptor availability is reduced in methamphetamine dependence and is linked to impulsivity
    Buyean Lee
    Department of Psychiatry, Brain Research Institute, University of California, Los Angeles, Los Angeles, California 90024, USA
    J Neurosci 29:14734-40. 2009
    ..12 corrected). The findings suggest that low striatal D(2)/D(3) receptor availability may mediate impulsive temperament and thereby influence addiction...
  44. pmc Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
    Raymond H Kim
    Campbell Family Institute for Breast Cancer Research, Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada M5G 2C1
    Proc Natl Acad Sci U S A 102:5215-20. 2005
    ..Thus, DJ-1 protects against neuronal oxidative stress, and loss of DJ-1 may lead to Parkinson's disease by conferring hypersensitivity to dopaminergic insults...
  45. ncbi Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  46. ncbi Differential tonic GABA conductances in striatal medium spiny neurons
    Kristen K Ade
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 28:1185-97. 2008
    ....
  47. pmc Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum
    Mai T Dang
    Department of Molecular and Integrative Physiology, NeuroTech Group, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Proc Natl Acad Sci U S A 103:15254-9. 2006
    ....
  48. ncbi Distinct roles of synaptic transmission in direct and indirect striatal pathways to reward and aversive behavior
    Takatoshi Hikida
    Department of Systems Biology, Osaka Bioscience Institute, 6 2 4 Furuedai, Suita, Osaka 565 0874, Japan
    Neuron 66:896-907. 2010
    ..These two pathways thus have distinct roles: the direct pathway critical for distinguishing associative rewarding stimuli from nonassociative ones and the indirect pathway for rapid memory formation to avoid aversive stimuli...
  49. ncbi Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction
    Nora D Volkow
    National Institute on Alcohol Abuse and Alcoholism, Bethesda Maryland 20892, USA
    J Neurosci 26:6583-8. 2006
    ..Because craving is a key contributor to relapse, strategies aimed at inhibiting dopamine increases from conditioned responses are likely to be therapeutically beneficial in cocaine addiction...
  50. ncbi Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice
    V C Wheeler
    Molecular Neurogenetics Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Hum Mol Genet 9:503-13. 2000
    ....
  51. ncbi The computational neurobiology of learning and reward
    Nathaniel D Daw
    Gatsby Computational Neuroscience Unit, UCL, Alexandra House, 17 Queen Square, London, WC1N 3AR, UK
    Curr Opin Neurobiol 16:199-204. 2006
    ....
  52. ncbi L-DOPA-induced dyskinesia in the rat is associated with striatal overexpression of prodynorphin- and glutamic acid decarboxylase mRNA
    M A Cenci
    Wallenberg Neuroscience Center, Institute of Physiology and Neuroscience, University of Lund, 223 62 Lund, Sweden
    Eur J Neurosci 10:2694-706. 1998
    ..Due to its treatment-dependent expression, and strong correlation with the associated dyskinetic symptoms, striatal PDyn mRNA, in particular, may play a role in the mechanisms of behavioural sensitization brought about by the drug...
  53. ncbi A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration
    J G Hodgson
    Centre for Molecular Medicine and Therapeutics, University of British Columbia, Vancouver, Canada
    Neuron 23:181-92. 1999
    ..These mice demonstrate that initial neuronal cytoplasmic toxicity is followed by cleavage of htt, nuclear translocation of htt N-terminal fragments, and selective neurodegeneration...
  54. ncbi Impulsive personality predicts dopamine-dependent changes in frontostriatal activity during component processes of working memory
    Roshan Cools
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720 3190, USA
    J Neurosci 27:5506-14. 2007
    ..The present results provide a key link between dopamine D2 receptor function, impulsivity, and frontostriatal activity during component processes of working memory...
  55. pmc Dichotomous anatomical properties of adult striatal medium spiny neurons
    Tracy S Gertler
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 28:10814-24. 2008
    ..Thus, rather than being an intrinsically homogenous population, striatal MSNs have dichotomous somatodendritic properties that mirror differences in their network connections and biochemistry...
  56. pmc Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
    Tohru Kitada
    Center for Neurologic Diseases, Brigham and Women s Hospital, Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:11441-6. 2007
    ..These results reveal a critical role for PINK1 in DA release and striatal synaptic plasticity in the nigrostriatal circuit and suggest that altered dopaminergic physiology may be a pathogenic precursor to nigrostriatal degeneration...
  57. pmc Action dominates valence in anticipatory representations in the human striatum and dopaminergic midbrain
    Marc Guitart-Masip
    Institute of Cognitive Neuroscience, University College London, London, W1CN 4AR, United Kingdom
    J Neurosci 31:7867-75. 2011
    ..This dominant influence of action requires an enriched notion of opponency between reward and punishment...
  58. pmc Dopamine modulation of GABA tonic conductance in striatal output neurons
    Megan J Janssen
    Department of Physiology and Biophysics, Georgetown University School of Medicine, Washington, DC 20007, USA
    J Neurosci 29:5116-26. 2009
    ..Our results suggest that distinct phosphorylation of beta3-subunits may cause larger tonic current in D2+ striatopallidal MSNs, and proper intracellular conditions can reveal tonic current in D1+ cells...
  59. ncbi Reinforcement learning signals in the human striatum distinguish learners from nonlearners during reward-based decision making
    Tom Schonberg
    Department of Psychology, Tel Aviv University, Tel Aviv 69978, Israel
    J Neurosci 27:12860-7. 2007
    ..Thus, spontaneously observed individual differences in decision making performance demonstrate the suggested dependence of this type of learning on the functional integrity of the dopaminergic striatal system in humans...
  60. ncbi Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein
    Sheila M Fleming
    Department of Neurology, The Mental Retardation Research Center, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 24:9434-40. 2004
    ..These behavioral deficits provide a useful way to assess novel drug therapy in genetic models of synucleinopathies...
  61. ncbi Human striatal response to salient nonrewarding stimuli
    Caroline F Zink
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:8092-7. 2003
    ..These results demonstrate a role of the striatum in coding nonrewarding salient events. In addition, a functional subdivision of the striatum according to the behavioral relevance of the stimuli is suggested...
  62. pmc A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice
    Alexander Kurz
    Department of Neurology, Goethe University Medical School, Frankfurt, Germany
    PLoS ONE 5:e11464. 2010
    ..PD is characterized pathologically by the preferential vulnerability of the dopaminergic nigrostriatal projection neurons...
  63. ncbi Slowed progression in models of Huntington disease by adipose stem cell transplantation
    Soon Tae Lee
    Department of Neurology, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea
    Ann Neurol 66:671-81. 2009
    ..Adipose-derived stem cells (ASCs) are readily accessible and secrete multiple growth factors. Here, we show that ASC transplantation rescues the striatal pathology of Huntington disease (HD) models...
  64. ncbi The endocannabinoid 2-arachidonoylglycerol produced by diacylglycerol lipase alpha mediates retrograde suppression of synaptic transmission
    Asami Tanimura
    Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Neuron 65:320-7. 2010
    ..We conclude that 2-AG produced by DGLalpha, but not by DGLbeta, mediates retrograde suppression at central synapses...
  65. ncbi Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats
    J Chen
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    J Neurol Sci 189:49-57. 2001
    ..05), somatosensory (p<0.05) and NSS (p<0.05) behavioral tests compared with control animals. Our data suggest that intracerebral transplantation of MSCs may provide a powerful autoplastic therapy for stroke...
  66. ncbi Tracking the hemodynamic responses to reward and punishment in the striatum
    M R Delgado
    Department of Neuroscience, University of Pittsburgh and Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania 15260, USA
    J Neurophysiol 84:3072-7. 2000
    ..Activation was sustained following a reward feedback, but decreased below baseline following a punishment feedback...
  67. pmc Striatal dopamine predicts outcome-specific reversal learning and its sensitivity to dopaminergic drug administration
    Roshan Cools
    Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurosci 29:1538-43. 2009
    ..These data demonstrate that the effects of D(2) receptor stimulation on reversal learning in humans depend on task demands and baseline striatal dopamine synthesis capacity...
  68. ncbi Dopamine release in dissociable striatal subregions predicts the different effects of oral methylphenidate on reversal learning and spatial working memory
    Philip L Clatworthy
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge CB2 3EB, United Kingdom
    J Neurosci 29:4690-6. 2009
    ....
  69. ncbi Reduced prefrontal activity predicts exaggerated striatal dopaminergic function in schizophrenia
    Andreas Meyer-Lindenberg
    Unit on Integrative Neuroimaging, National Institute of Mental Health, National Institutes of Health, 10 4C101, 9000 Rockville Pike, Bethesda, Maryland 20892 1365, USA
    Nat Neurosci 5:267-71. 2002
    ....
  70. pmc Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions
    Sreeganga Chandra
    Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 101:14966-71. 2004
    ..These results show that synucleins are not essential components of the basic machinery for neurotransmitter release but may contribute to the long-term regulation and/or maintenance of presynaptic function...
  71. ncbi The connections of the dopaminergic system with the striatum in rats and primates: an analysis with respect to the functional and compartmental organization of the striatum
    D Joel
    Department of Psychology, Tel Aviv University, Ramat Aviv, Tel Aviv, Israel
    Neuroscience 96:451-74. 2000
    ..Finally, we incorporate the striatal connections with the dopaminergic system into an open-interconnected scheme of basal ganglia-thalamocortical circuitry...
  72. ncbi Evidence for differential cortical input to direct pathway versus indirect pathway striatal projection neurons in rats
    Wanlong Lei
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 24:8289-99. 2004
    ..This differential cortical connectivity may further the roles of the direct and indirect pathways in promoting desired movements and suppressing unwanted movements, respectively...
  73. pmc Striatal microcircuitry and movement disorders
    Aryn H Gittis
    Gladstone Institute of Neurological Disease, San Francisco, CA, USA
    Trends Neurosci 35:557-64. 2012
    ..Because interneurons are genetically and neurochemically unique from striatal projection neurons, they may provide promising therapeutic targets for the treatment of a variety of striatal-based disorders...
  74. pmc Strain-specific regulation of striatal phenotype in Drd2-eGFP BAC transgenic mice
    C Savio Chan
    Department of Physiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 32:9124-32. 2012
    ..Thus, the use of inbred strains of mice that are hemizygous for the Drd2 BAC transgene provides a reliable tool for studying basal ganglia function...
  75. pmc GABAergic circuits mediate the reinforcement-related signals of striatal cholinergic interneurons
    Daniel F English
    Center for Molecular and Behavioral Neuroscience, Rutgers University, Newark, New Jersey, USA
    Nat Neurosci 15:123-30. 2012
    ..These results reveal a previously unknown circuit mechanism that transmits reinforcement-related information of ChAT interneurons in the mouse neostriatal network...
  76. ncbi Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system
    A Abeliovich
    Department of Neurology, University of California, San Francisco 94143, USA
    Neuron 25:239-52. 2000
    ..These findings support the hypothesis that alpha-Syn is an essential presynaptic, activity-dependent negative regulator of DA neurotransmission...
  77. ncbi Subcellular arrangement of molecules for 2-arachidonoyl-glycerol-mediated retrograde signaling and its physiological contribution to synaptic modulation in the striatum
    Motokazu Uchigashima
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    J Neurosci 27:3663-76. 2007
    ..Thus, endocannabinoid signaling molecules are arranged to modulate the excitability of the MS neuron effectively depending on cortical activity and cholinergic tone as measured by mGluR5 and M1 receptors, respectively...
  78. ncbi Decreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
    N D Volkow
    Medical Department, Brookhaven National Laboratory, Upton, New York 11973, USA
    Nature 386:830-3. 1997
    ..Moreover, they suggest a participation of thalamic dopamine pathways in cocaine addiction, a possibility that merits further investigation...
  79. pmc RGS4 is required for dopaminergic control of striatal LTD and susceptibility to parkinsonian motor deficits
    Talia N Lerner
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 73:347-59. 2012
    ..Taken together, these results suggest that inhibition of RGS4 may be an effective nondopaminergic strategy for treating Parkinson's disease...
  80. pmc Retinoic acid and environmental enrichment alter subventricular zone and striatal neurogenesis after stroke
    Jennifer M Plane
    University of Michigan Department of Neurology, Ann Arbor, MI 48109 2200, USA
    Exp Neurol 214:125-34. 2008
    ..Further study of the integration of adult-born neurons in the ischemic striatum is necessary to determine their restorative potential...
  81. pmc Neurogenetics and pharmacology of learning, motivation, and cognition
    Michael J Frank
    Department of Cognitive, Linguistic and Psychological Sciences, Brown Institute for Brain Science, Brown University, Providence, RI 02912 1978, USA
    Neuropsychopharmacology 36:133-52. 2011
    ..We discuss the merits and caveats of this approach and outline a number of novel candidate genes of interest for future study...
  82. ncbi Methamphetamine-induced structural plasticity in the dorsal striatum
    Jakub P Jedynak
    Neuroscience Program, The University of Michigan, Ann Arbor, MI, USA
    Eur J Neurosci 25:847-53. 2007
    ....
  83. pmc Roles for nigrostriatal--not just mesocorticolimbic--dopamine in reward and addiction
    Roy A Wise
    Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, USA
    Trends Neurosci 32:517-24. 2009
    ..Thus, the similarities between nigrostriatal and mesolimbic dopamine systems can be as important as their differences...
  84. pmc AMPAR-independent effect of striatal αCaMKII promotes the sensitization of cocaine reward
    Said Kourrich
    Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci 32:6578-86. 2012
    ..This study identifies CaMKII regulation of IA in NAc shell neurons as a novel cellular contributor to the sensitization of cocaine reward...
  85. ncbi Dopaminergic control of synaptic plasticity in the dorsal striatum
    D Centonze
    Clinica Neurologica, Dip. Neuroscienze, , Via di Tor Vergata 135, Rome 00133, Italy
    Eur J Neurosci 13:1071-7. 2001
    ..These kinases appear to be stimulated by the activation of D1-like receptors in distinct neuronal populations...
  86. pmc Intergenerational and striatal CAG repeat instability in Huntington's disease knock-in mice involve different DNA repair genes
    Ella Dragileva
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston MA 02114, USA
    Neurobiol Dis 33:37-47. 2009
    ....
  87. ncbi Behavioral phenotyping of the MPTP mouse model of Parkinson's disease
    M Sedelis
    Institute of Physiological Psychology I and Center for Biological and Medical Research, Heinrich Heine University of Dusseldorf, Universitatsstrasse 1, 40225 Dusseldorf, Germany
    Behav Brain Res 125:109-25. 2001
    ..g. mice with a manipulation of genes relevant to the function of the basal ganglia...
  88. pmc Distinct roles of GABAergic interneurons in the regulation of striatal output pathways
    Aryn H Gittis
    Gladstone Institute of Neurological Disease, Department of Physiology, and Department of Neurology, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:2223-34. 2010
    ..Surprisingly, we find that FS interneurons preferentially target direct-pathway MSNs over indirect-pathway MSNs, suggesting a potential mechanism for rapid pathway-specific regulation of striatal output pathways...
  89. ncbi Dopamine-mediated regulation of corticostriatal synaptic plasticity
    Paolo Calabresi
    Clinica Neurologica, Universita di Perugia, Ospedale S Maria della Misericordia, Via S Andrea delle Fratte, 06156, Perugia, Italy
    Trends Neurosci 30:211-9. 2007
    ..Finally, we discuss how endogenous dopamine crucially influences changes in synaptic plasticity induced by pathological stimuli, such as energy deprivation...
  90. ncbi Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    Jiandie Lin
    Dana Farber Cancer Institute and Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
    Cell 119:121-35. 2004
    ..These data illustrate a central role for PGC-1alpha in the control of energy metabolism but also reveal novel systemic compensatory mechanisms and pathogenic effects of impaired energy homeostasis...
  91. ncbi Temporal difference models and reward-related learning in the human brain
    JOHN P O'DOHERTY
    Wellcome Department of Imaging Neuroscience, Institute of Neurology, University College London, WC1N 3BG, London, United Kingdom
    Neuron 38:329-37. 2003
    ....
  92. ncbi Dopamine release in the dorsal striatum during cocaine-seeking behavior under the control of a drug-associated cue
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Cambridge, CB2 3EB, United Kingdom
    J Neurosci 22:6247-53. 2002
    ..These data indicate a possible involvement of the dopaminergic innervation of the dorsal striatum in well established, or habitual, cocaine-seeking behavior...
  93. ncbi Targeting adenosine A2A receptors in Parkinson's disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02129, USA
    Trends Neurosci 29:647-54. 2006
    ..Thus, we review here a prime example of translational neuroscience, through which antagonism of A2A receptors has now entered the arena of clinical trials with realistic prospects for advancing PD therapeutics...
  94. ncbi Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation
    Alexis Faure
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, Unité Mixte de Recherche 8620, Universite Paris Sud, 91405 Orsay Cedex, France
    J Neurosci 25:2771-80. 2005
    ..In dopamine-depleted rats, lever press and chain pull remained sensitive to reward devaluation, evidencing a role of striatal dopamine transmission in habit formation...
  95. pmc Dichotomous dopaminergic control of striatal synaptic plasticity
    Weixing Shen
    Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
    Science 321:848-51. 2008
    ..In models of Parkinson's disease, this system is thrown out of balance, leading to unidirectional changes in plasticity that could underlie network pathology and symptoms...
  96. ncbi Microglial activation precedes dopamine terminal pathology in methamphetamine-induced neurotoxicity
    Matthew J LaVoie
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Exp Neurol 187:47-57. 2004
    ..These observations raise the possibility that activated microglia may contribute to methamphetamine-induced neurotoxicity...
  97. ncbi Dynamics of synaptic transmission between fast-spiking interneurons and striatal projection neurons of the direct and indirect pathways
    Henrike Planert
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurosci 30:3499-507. 2010
    ..Our findings show that the two intrastriatal inhibitory pathways have fundamentally different dynamic properties that are, however, similarly applied to both direct and indirect striatal projections...
  98. ncbi Characterization of behavioral and neurodegenerative changes following partial lesions of the nigrostriatal dopamine system induced by intrastriatal 6-hydroxydopamine in the rat
    D Kirik
    Department of Physiology and Neuroscience, Lund University, Solvegatan 17, Lund, 223 62, Sweden
    Exp Neurol 152:259-77. 1998
    ....
  99. ncbi Differential aging of the human striatum: longitudinal evidence
    Naftali Raz
    Institute of Gerontology and Department of Psychology, Wayne State University, Detroit MI, USA
    AJNR Am J Neuroradiol 24:1849-56. 2003
    ....
  100. ncbi Slower progression of Parkinson's disease with ropinirole versus levodopa: The REAL-PET study
    Alan L Whone
    Faculty of Medicine, Imperial College, Hammersmith Hospital, London, United Kingdom
    Ann Neurol 54:93-101. 2003
    ..1%; levodopa, -22.9%; 95% CI, 4.24-13.3), but the decrease was significantly lower with ropinirole compared with levodopa (p < 0.001). Ropinirole is associated with slower progression of PD than levodopa as assessed by (18)F-dopa PET...
  101. pmc Striatum and pre-SMA facilitate decision-making under time pressure
    Birte U Forstmann
    Department of Psychology, Amsterdam Center for the Study of Adaptive Control in Brain and Behavior, University of Amsterdam, 1018 WB, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:17538-42. 2008
    ..These results demonstrate that when people have to make decisions under time pressure their striatum and pre-SMA show increased levels of activation...

Research Grants62

  1. NEUROCHEMICAL ACTIONS OF PSYCHOTROPIC DRUGS
    Solomon H Snyder; Fiscal Year: 2013
    ..genetic basis of Huntington's Disease 16 years ago, how it elicited the highly selective damage to the corpus striatum characteristic of HD was unclear, because Htt is uniformed expressed throughout the brain and the rest of the ..
  2. Gene-environment interactions between manganese exposure and Huntington disease
    Aaron B Bowman; Fiscal Year: 2012
    ..Furthermore, a major site of Mn accumulation in the brain is the corpus striatum, which contains the neurons most vulnerable in HD...
  3. HYPOTHALAMUS & NARCOTIC EFFECTS
    HEMENDRA BHARGAVA; Fiscal Year: 1992
    ..mu), 3 H-DPDPE (delta) and 3 H-U 69593 (k) to CNS regions (spinal cord, amygdala, hippocampus, hypothalamus, corpus striatum, pons and medulla, midbrain and cerebral cortex) will be determined...
  4. NEURON TRANSPLANT THERAPY: A MODEL OF PARKINSONISM
    MARK DUBACH; Fiscal Year: 1990
    ..Dopamine cells, transplanted from a macaque fetus into the corpus striatum, measurably reverse this syndrome...
  5. THE ROLE OF TYROSINE METABOLISM IN LIVER DISEASE
    BAHJAT FARAJ; Fiscal Year: 1980
    ..Furthermore, the depletion in brain (hypothalamus, corpus striatum, etc) catecholamines and their subsequent elevation in CSF of shunted dogs closely resembles our recent ..
  6. MECHANISMS OF MUSCARINIC RECEPTOR CROSS-TALK IN BRAIN
    FRED EHLERT; Fiscal Year: 1993
    ..hydrolysis and inhibition of adenylate cyclase activity will be defined in identical preparations of the corpus striatum and parotid gland using pharmacological null methods and radioligand binding methods to analyze the ..
  7. VITAMIN B6 IN DEVELOPMENT OF CENTRAL NERVOUS SYSTEM
    Avanelle Kirksey; Fiscal Year: 1980
    ..Specific regions of the developing brain (corpus striatum, cerebellar cortex, hypothalamus) and spinal cord (C-1 segment) in progeny of mothers fed different levels of ..
  8. MUSCARINIC RECEPTOR COUPLING MECHANISMS IN THE BRAIN
    FRED EHLERT; Fiscal Year: 1992
    ..hydrolysis and inhibition of adenylate cyclase will be defined in identical preparations of the corpus striatum and parotid gland by using pharmacological null methods and radioligand binding methods to analyze the ..
  9. Neural Circuitry of Social Behavior in Bonnet Macaques
    Jack Gorman; Fiscal Year: 2003
    ..The major region of interest is the corpus striatum, reflecting a convergence of evidence of this region's role in modulating brain reward pathways, which might ..
  10. BEHAVIORAL & BIOCHEMICAL CORRELATES OF DOPAMINE RESPONSE
    Bahr Weiss; Fiscal Year: 1993
    ..to study altered dopaminergic function is the well characterized model of mice with unilateral lesions of the corpus striatum induced by injecting 6-hydroxdopamine...
  11. NONGENOMIC STIMULATION OF ESTROGEN
    Victor Ramirez; Fiscal Year: 2001
    ..between a particular chemical group of the steroid and a specific binding domain in the mER of the corpus striatum (CS) cells...
  12. METHYL DONOR DEFICIT AFTER N2O WITH OTHER DRUGS
    ROY DORRIS; Fiscal Year: 1990
    ..Some preliminary studies in mice support this hypothesis, in that brain corpus striatum, which has a high rate of dopamine o-methylation, showed a decrease in SAMe concentrations distinct from that ..
  13. POSTNATAL ETHANOL EXPOSURE AND NEUROCHEMICAL DEVELOPMENT
    Kim Light; Fiscal Year: 1993
    ..Brain regions to be analyzed include: cerebral cortex, corpus striatum, hippocampus, and cerebellum...
  14. MULTIPLE FORMS OF HUMAN TYROSINE HYDROXYLASE
    John Haycock; Fiscal Year: 1992
    ..of HTH in LA-N human neuroblastoma cells, of HTH in intact post-mortem human tissues (synaptosomes from corpus striatum and nucleus accumbens, chromaffin cells from adrenal medullae), and of HTH in cells isolated from human ..
  15. MATERNAL B6 DEFICIENCY
    TOMAS GUILARTE; Fiscal Year: 1993
    ..On the other hand, for other system (e.g. the dopaminergic in the corpus striatum), the neurochemical deficit persists into adulthood...
  16. KINETICS OF CELL PROLIFERATION IN THE STRIATUM
    Pradeep Bhide; Fiscal Year: 1999
    ..research program are to characterize the mechanisms which regulate the generation of neurons destined for the corpus striatum (a component of the basal ganglia of the forebrain) during normal development or under pathological ..
  17. BIOGENIC AMINE/DRUG EFFECTS ON CNS RECEPTOR
    ROBERT FRIEDEL; Fiscal Year: 1980
    ..set for the past year were to evaluate the effects of acetylcholine on phospholipid metabolism of the rat corpus striatum, to determine potency of inhibition of a variety of cholinergic antagonists on these effects, and to ..
  18. NEURAL AND MOLECULAR MECHANISMS IN STRIATAL LEARNING
    CARMEN MALDONADO VLAAR; Fiscal Year: 2002
    ..The nucleus accumbens and other areas of the corpus striatum have previously been implicated in mediating the motor activation and reinforcing effects of psychostimulant ..
  19. FUNCTIONAL MECHANISMS OF THE CORPUS STRIATUM
    Robert Beckstead; Fiscal Year: 1991
    ..More generally, the increased understanding of functional mechanisms within the corpus striatum will contribute to the scientific basis for the study of clinical disorders associated with corpus striatal ..
  20. ETHANOL AND AGING: CHOLINERGIC RELATIONSHIPS
    CARLTON ERICKSON; Fiscal Year: 1990
    ..Other studies will examine whether central cholinergic changes occur in the cerebral cortex, hippocampus, corpus striatum, and brainstem of rats under conditions similar to those in the Basic studies...
  21. Nicotinic and neuroprotection in a parkinson mouse model
    Maryka Quik; Fiscal Year: 2007
    ..This may allow for the design of neuroprotective strategies for PD, a disorder for which only symptomatic treatment is currently available. ..
  22. Nicotinic Receptors in Parkinson's Disease
    Maryka Quik; Fiscal Year: 2007
    ..These data together with the results of the behavioral studies may form a basis for the use of nicotinic drugs in the treatment of Parkinson's disease. [unreadable] [unreadable]..
  23. NICOTINE EFFECTS ON CEREBRAL BLOOD FLOW AND METABOLISM
    EDWARD DOMINO; Fiscal Year: 2001
    ..This could set the stage for the study of nicotine effects in persons with cofactors for smoking, such as attention deficit disorder or mood disorders. ..
  24. Effects of Nicotine on Human Cerebral Transmitters
    EDWARD DOMINO; Fiscal Year: 2008
    ..This research will provide direct proof of basic neuroscience studies, which indicate nicotine releases neurotransmitters such as dopamine and endogenous opioids. [unreadable] [unreadable] [unreadable]..
  25. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  26. Calcitriol and Methamphetamine Neurotoxicity
    Wayne Cass; Fiscal Year: 2008
    ..Furthermore, if calcitriol is effective, it could have therapeutic applications in other disease processes where there is a loss of monoamine neurons, such as in Parkinson's disease. [unreadable] [unreadable] [unreadable]..
  27. Depression Prevention Program for High-Risk Adolescents
    Eric Stice; Fiscal Year: 2008
    ..Thus, the proposed project should provide a rigorous evaluation of this promising brief prevention program and should advance knowledge regarding the prevention of this pernicious psychiatric problem. [unreadable] [unreadable]..
  28. Calcitriol-Induced Restoration of Dopamine in a Model of Parkinson's Disease
    Wayne Cass; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. Eating Disorder Prevention Program Effectiveness Trial
    Eric Stice; Fiscal Year: 2009
    ..g. will use random assignment, an attention control condition, blinded diagnostic interviews, multiple-reporter data, and a long-term follow-up). ..
  30. Risk and Maintenance Factors for Bulimic Pathology
    Eric Stice; Fiscal Year: 2006
    ..abstract_text> ..
  31. Multiple Memory Systems in Action Selection
    JOSHUA BERKE; Fiscal Year: 2005
    ..abstract_text> ..
  32. AGING AND 6 HYDROXYDOPAMINE NEUROTOXICITY
    Wayne Cass; Fiscal Year: 2005
    ....
  33. TEST OF A DISSONANCE EATING DISORDER PREVENTION PROGRAM
    Eric Stice; Fiscal Year: 2005
    ..Thus, the proposed study should be the definitive test of this new promising eating disorder prevention program and should significantly advance our knowledge regarding the prevention of this pervasive psychiatric problem. ..
  34. DOPAMINE AND GABA IMAGING IN SCHIZOPHRENIA
    Lawrence Kegeles; Fiscal Year: 2004
    ..abstract_text> ..
  35. Acoustic Interference on Attention in HIV Patients
    Dardo Tomasi; Fiscal Year: 2003
    ..More generally, this study will also improve the understanding of the neural effects of acoustic noise interference during fMRI studies in healthy populations. ..
  36. ETIOLOGY OF BULIMIC PATHOLOGY--MULTIMETHOD INVESTIGATION
    Eric Stice; Fiscal Year: 2002
    ..Agras' and Taylor's labs, (2) learn state-of- the-art treatments for eating pathology and other adolescent psychopathology, (3) take courses in quantitative techniques, methodology, and ethics, and (4) receive training in grant writing. ..
  37. Dopamine Genetic Variants Modulating Recovery After TBI
    Amy Wagner; Fiscal Year: 2008
    ..Through neurolmaging, we hope to better understand how genetics Influences who may benefit from a relevant rehabilitation-based pharmacological treatment strategy. [unreadable] [unreadable] [unreadable]..
  38. Selective Prenatal Dopamine Damage in Non Human Primates
    John Elsworth; Fiscal Year: 2003
    ..Thus, the proposed work may lead ultimately to an animal model for one or more pediatric brain disorders. ..
  39. Gender Differences in Dopamine Function after TBI
    Amy Wagner; Fiscal Year: 2003
    ....
  40. Stem Cell Adaptability in Parkinson' Disease
    DAVID YUREK; Fiscal Year: 2009
    ..The variable of host age on ESC-derived dopamine neuron adaptability will be studied. ..
  41. Biomechanics of Slips in Older Adults
    Rakie Cham; Fiscal Year: 2009
    ..This fundamental knowledge is required to plan, to develop and to implement effective deficits-targeted interventions focused on minimizing the risk of falling in the workplace. ..
  42. Effects of Chronic THC in Adolescence
    Peter J Winsauer; Fiscal Year: 2010
    ..Together, data from these experiments will demonstrate how drug abuse and hormonal status during adolescence may permanently alter brain function and the liability of subsequent abuse of A9-THC. ..
  43. Huntington's Disease and the Striatum
    Michelle E Ehrlich; Fiscal Year: 2010
    ..Knowledge of striatal-specific transcriptional regulation will also be highly relevant to other diseases of the basal ganglia in which transcriptional dysregulation plays a role. II. ..
  44. Dysfunctional Cortico-Limbic Activity and Connectivity in Bipolar Disorder and Li
    Amit Anand; Fiscal Year: 2010
    ..This study will also establish an experimental paradigm to study brain connectivity which could be used to investigate other disorders. ..
  45. Measuring Striatal Neurotransmission in Behaving Rats after Experimental TBI
    Amy Wagner; Fiscal Year: 2008
    ..The overarching goal is to gain insight into potential mechanisms of action and efficacy of these interventions on cognition and recovery for the clinical population with TBI. [unreadable] [unreadable] [unreadable]..
  46. Dopamine Function in TBI--Therapeutic Intervention
    Amy Wagner; Fiscal Year: 2005
    ..The Departments of Physical Medicine and Rehabilitation, Neurosurgery, Anesthesia/Critical Care Medicine, and Safar Center for Resuscitation Research provide the environment for this study of experimental and clinical brain injury. ..
  47. Mechanisms of Long-Term Depression in the Striatum
    Anatol Kreitzer; Fiscal Year: 2005
    ..These studies will provide a framework for understanding how long-term changes in synaptic strength in the striatum are related to such health issues as addiction and neurodegenerative disease. ..
  48. Detection of Dopamine Release During a Cognitive Task
    RAJENDRA BADGAIYAN; Fiscal Year: 2006
    ..This study will determine whether the molecular imaging technique can be reliably used to investigate an unexplored aspect (neurotransmission) of human cognition. [unreadable] [unreadable]..
  49. WINTER CONFERENCE ON BRAIN RESEARCH
    DALTON SURMEIER; Fiscal Year: 2005
    ..Particular emphasis will be placed on obtaining a diverse group of fellows with respect to parent institution, gender, and minority status. ..
  50. Dopamine function in social phobia & related conditions
    Franklin Schneier; Fiscal Year: 2006
    ..Better understanding of the neurocircuitry associated with GSP holds promise for improving diagnosis and treatment strategies. ..
  51. Combination Treatment for PTSD After the WTC Attack
    Franklin Schneier; Fiscal Year: 2008
    ..Findings may enhance public health through the study of maximization of treatment response for this serious and common psychiatric disorder. ..
  52. Gene Therapy, Neural Grafts & Parkinson's Disease
    DAVID YUREK; Fiscal Year: 2005
    ..These studies will also determine if combinations of viral vectors expressing different neurotrophic factors can be used to improve the therapeutic effects of dopamine grafts. ..
  53. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
    ....
  54. MONOAMINERGIC MODULATION OF PREFRONTAL CORTEX
    DALTON SURMEIER; Fiscal Year: 2004
    ..Achieving these specific aims will provide the molecular and cellular framework necessary to begin building an accurate, integrative model of PFC function and dysfunction in schizophrenia. ..
  55. DOPAMINERGIC AND MUSCARINIC SIGNALING IN THE STRIATUM
    DALTON SURMEIER; Fiscal Year: 2007
    ....
  56. Molecular Regulation of a Striatal DARPP-32 Phenotype
    Michelle Ehrlich; Fiscal Year: 2008
    ....
  57. Neural circuitry of submissive behavior and treatment response in social anxiety
    Franklin Schneier; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  58. Simultaneous PET imaging of rCBF and dopamine release
    ALEXANDER CONVERSE; Fiscal Year: 2006
    ....