mediodorsal thalamic nucleus

Summary

Summary: The largest of the medial nuclei of the thalamus. It makes extensive connections with most of the other thalamic nuclei.

Top Publications

  1. pmc The primate working memory networks
    Christos Constantinidis
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Cogn Affect Behav Neurosci 4:444-65. 2004
  2. ncbi Thalamic mediodorsal nucleus and working memory
    Yumiko Watanabe
    Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8568, Japan
    Neurosci Biobehav Rev 36:134-42. 2012
  3. ncbi Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. II. Activity encoding visual versus motor signal
    Yumiko Watanabe
    Dept of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Neurophysiol 92:1756-69. 2004
  4. ncbi Neural correlates of stimulus-reward association in the rat mediodorsal thalamus
    Takashi Kawagoe
    Department of Integrative Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuroreport 18:683-8. 2007
  5. ncbi Mediodorsal thalamic nucleus receives a direct retinal input in marmoset monkey (Callithrix jacchus): a subunit B cholera toxin study
    Twyla Barros de Sousa
    Department of Morphology Laboratory of Neuroanatomy, Biosciences Center, Federal University of Rio Grande do Norte, RN, Brazil
    Ann Anat 195:32-8. 2013
  6. pmc Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluation
    Alicia Izquierdo
    Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892 4415, USA
    J Neurosci 30:661-9. 2010
  7. ncbi Fornix, medial prefrontal cortex, nucleus accumbens, and mediodorsal thalamic nucleus: roles in a fear-based context discrimination task
    Elena A Antoniadis
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Neurobiol Learn Mem 85:71-85. 2006
  8. ncbi Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. I. Cue-, delay-, and response-period activity
    Yumiko Watanabe
    Dept of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Neurophysiol 92:1738-55. 2004
  9. ncbi The role of the mediodorsal thalamic nucleus in human olfaction
    Wendy W P Tham
    Department of Psychology, Macquarie University, NSW, Australia
    Neurocase 17:148-59. 2011
  10. ncbi Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and gamma-aminobutyric acidergic cortical cells in the prelimbic cortex of the rat
    Masaru Kuroda
    Department of Anatomy, Toho University School of Medicine, Ohta ku, Tokyo 143 8540, Japan
    J Comp Neurol 477:220-34. 2004

Research Grants

  1. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
  2. Response properties of hypothalamic MCH neurons
    Anthony N van den Pol; Fiscal Year: 2013
  3. ORGANIZATION OF PREFRONTAL FEEDBACK CIRCUITS
    Helen Barbas; Fiscal Year: 2013
  4. Neural circuits underlying circadian regulation of behavior and physiology
    Nina Vujovic; Fiscal Year: 2012
  5. Circuitry for circadian rhythms
    Clifford B Saper; Fiscal Year: 2013
  6. To Feed or Breed? GnIH-3 Stimulates Food Intake in Rats
    Gregory Scott Fraley; Fiscal Year: 2013
  7. Circuitry of Emotion: Integration in the Orbitofrontal Cortex
    CLARE TIMBIE; Fiscal Year: 2013
  8. Defects of subcellular glutamate transporter localization in schizophrenia
    Robert E McCullumsmith; Fiscal Year: 2013
  9. The role of the thalamus in human olfactory processing
    CHRISTINA MARIA ZELANO; Fiscal Year: 2012
  10. HYPOTHALAMIC CONTROL OF PROLACTIN SECRETION
    JAMES VOOGT; Fiscal Year: 2001

Detail Information

Publications200 found, 100 shown here

  1. pmc The primate working memory networks
    Christos Constantinidis
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Cogn Affect Behav Neurosci 4:444-65. 2004
    ..The neural mechanisms of memory maintenance and the integrative role of the prefrontal cortex are also discussed...
  2. ncbi Thalamic mediodorsal nucleus and working memory
    Yumiko Watanabe
    Human Technology Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba 305 8568, Japan
    Neurosci Biobehav Rev 36:134-42. 2012
    ..These results indicate that reverberating neural circuits constructed by reciprocal connections between the MD and the PFC could be an important component for constructing prospective information in the PFC...
  3. ncbi Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. II. Activity encoding visual versus motor signal
    Yumiko Watanabe
    Dept of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Neurophysiol 92:1756-69. 2004
    ..These results suggest that although functional interactions between the MD and DLPFC are crucial to cognitive functions such as working memory, there is a difference in how the MD and DLPFC participate in these functions...
  4. ncbi Neural correlates of stimulus-reward association in the rat mediodorsal thalamus
    Takashi Kawagoe
    Department of Integrative Neuroscience, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Neuroreport 18:683-8. 2007
    Neural activity was recorded from the mediodorsal thalamic nucleus of behaving rats during the discrimination of olfactory cues associated with or without a reward...
  5. ncbi Mediodorsal thalamic nucleus receives a direct retinal input in marmoset monkey (Callithrix jacchus): a subunit B cholera toxin study
    Twyla Barros de Sousa
    Department of Morphology Laboratory of Neuroanatomy, Biosciences Center, Federal University of Rio Grande do Norte, RN, Brazil
    Ann Anat 195:32-8. 2013
    The mediodorsal thalamic nucleus is a prominent nucleus in the thalamus, positioned lateral to the midline nuclei and medial to the intralaminar thalamic complex in the dorsal thalamus...
  6. pmc Functional interaction of medial mediodorsal thalamic nucleus but not nucleus accumbens with amygdala and orbital prefrontal cortex is essential for adaptive response selection after reinforcer devaluation
    Alicia Izquierdo
    Section on the Neurobiology of Learning and Memory, Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, Maryland 20892 4415, USA
    J Neurosci 30:661-9. 2010
    ..In contrast, monkeys that sustained MDm disconnection failed to adjust their object choices. Thus, MDm, but not NA, works together with the amygdala and PFo to support reward-based decision making...
  7. ncbi Fornix, medial prefrontal cortex, nucleus accumbens, and mediodorsal thalamic nucleus: roles in a fear-based context discrimination task
    Elena A Antoniadis
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Neurobiol Learn Mem 85:71-85. 2006
    ....
  8. ncbi Neuronal activity throughout the primate mediodorsal nucleus of the thalamus during oculomotor delayed-responses. I. Cue-, delay-, and response-period activity
    Yumiko Watanabe
    Dept of Cognitive and Behavioral Sciences, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    J Neurophysiol 92:1738-55. 2004
    ..However, the manner in which these two structures participate in these processes differs, in that the MD participates more in motor control aspects compared with the DLPFC...
  9. ncbi The role of the mediodorsal thalamic nucleus in human olfaction
    Wendy W P Tham
    Department of Psychology, Macquarie University, NSW, Australia
    Neurocase 17:148-59. 2011
    ..These findings suggest that the MDNT pathway is involved, either specifically or generically, in mediating human olfactory attention...
  10. ncbi Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and gamma-aminobutyric acidergic cortical cells in the prelimbic cortex of the rat
    Masaru Kuroda
    Department of Anatomy, Toho University School of Medicine, Ohta ku, Tokyo 143 8540, Japan
    J Comp Neurol 477:220-34. 2004
    ..The anatomical findings indicate that GABAergic interneurons have a modulatory influence on excitatory reverberation between MD and the prefrontal cortex...
  11. ncbi Dissociation of spatial-, object-, and sound-coding neurons in the mediodorsal nucleus of the primate thalamus
    Ikuo Tanibuchi
    Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
    J Neurophysiol 89:1067-77. 2003
    ....
  12. pmc Dissociable performance on scene learning and strategy implementation after lesions to magnocellular mediodorsal thalamic nucleus
    Anna S Mitchell
    Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
    J Neurosci 27:11888-95. 2007
    ..These results provide new evidence about the role of the magnocellular mediodorsal thalamic nucleus in memory processing, indicating that interconnections with the prefrontal cortex are essential during ..
  13. pmc The mediodorsal thalamic nucleus and schizophrenia
    Raúl Alelú-Paz
    Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina, Universidad Autonoma de Madrid, Madrid, Spain
    J Psychiatry Neurosci 33:489-98. 2008
    ....
  14. ncbi Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: a replication study
    Peter Danos
    Department of Psychiatry, University Hospital Giessen and Marburg, Location Giessen, Germany
    Psychiatry Res 140:281-9. 2005
    Previous neuropathological studies on the mediodorsal thalamic nucleus (MD) in schizophrenia have yielded conflicting results...
  15. ncbi Comparative study of the effects of electrical stimulation in the nucleus accumbens, the mediodorsal thalamic nucleus and the bed nucleus of the stria terminalis in rats with schedule-induced polydipsia
    Kris van Kuyck
    Laboratory of Experimental Functional Neurosurgery, Department of Neurosciences, K U Leuven, Provisorium I, Minderbroedersstraat 17, 3000 Leuven, Belgium
    Brain Res 1201:93-9. 2008
    ..We aimed 1) to evaluate if electrical stimulation in the nucleus accumbens (N ACC), the mediodorsal thalamic nucleus (MD) or the bed nucleus of the stria terminalis (BST) can decrease water intake in the schedule-induced ..
  16. ncbi Morphometric characterization of synapses in the primate prefrontal cortex formed by afferents from the mediodorsal thalamic nucleus
    L Negyessy
    Yale University School of Medicine, Department of Neurobiology, Sterling Hall of Medicine B408, 333 Cedar Street, New Haven, CT, 0651, USA
    Exp Brain Res 164:148-54. 2005
    ....
  17. ncbi Dopamine innervation of the monkey mediodorsal thalamus: Location of projection neurons and ultrastructural characteristics of axon terminals
    D S Melchitzky
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 143:1021-30. 2006
    Dopamine (DA) axons and receptors have recently been identified in the primate thalamus, including the mediodorsal thalamic nucleus (MD)...
  18. ncbi Stereological analysis of the mediodorsal thalamic nucleus in schizophrenia: volume, neuron number, and cell types
    Karl Anton Dorph-Petersen
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Comp Neurol 472:449-62. 2004
    The mediodorsal thalamic nucleus (MD) is the principal relay nucleus for the prefrontal cortex, a brain region thought to be dysfunctional in schizophrenia...
  19. ncbi Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia
    William Byne
    Department of Psychiatry and Pathology, Mount Sinai School of Medicine, New York, USA
    Am J Psychiatry 159:59-65. 2002
    ..The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus...
  20. ncbi Neonatal neurosteroid administration alters parvalbumin expression and neuron number in medial dorsal thalamus of adult rats
    Samantha S Gizerian
    Curriculum in Neurobiology, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, NC 27599, USA
    Brain Res 1012:66-74. 2004
    ....
  21. ncbi Potent inhibitory effect of selective D2 and D3 agonists on dopamine-responsive dorsomedial arcuate neurons in brain slices of estrogen-primed rats
    S L Liang
    Department of Physiology, School of Life Science, National Yang-Ming University, Taipei, Taiwan, ROC
    Life Sci 69:2653-62. 2001
    ..In contrast, SKF81297, a D1 receptor agonist, induced variable responses in dmARN neurons. These results clearly indicate that DA may act through D2 and/or D3 receptors to exhibit an inhibitory effect on presumed TIDA neurons in dmARN...
  22. ncbi Elevated neuron number in the limbic thalamus in major depression
    Keith A Young
    Neuropsychiatry Research Program 151N, Central Texas Veterans Health Care System, 1901 S First Street, Temple, TX 76504, USA
    Am J Psychiatry 161:1270-7. 2004
    ..Neuroanatomical studies of the thalamus have rarely been conducted in patients with mood disorders...
  23. ncbi Locomotor activity induced by the non-competitive N-methyl-D-aspartate antagonist, MK-801: role of nucleus accumbens efferent pathways
    E De Leonibus
    Dipartimento di Genetica e Biologia Molecolare, , Ple. Aldo Moro 5, I-00185, Rome, Italy
    Neuroscience 104:105-16. 2001
    ..On the contrary, the motor nuclei of the thalamus appear to play a more relevant role, suggesting that different neural substrates may mediate dopamine and glutamate functional output from the nucleus accumbens...
  24. ncbi Visual attention in the rat: a role for the prelimbic cortex and thalamic nuclei?
    Y Chudasama
    School of Psychology, Cardiff University, Wales, United Kingdom
    Behav Neurosci 115:417-28. 2001
    ..The results suggest that different aspects of attention may be attributable to the PL and the MD and that the mechanisms underlying inhibitory control of behavior may be attributable to functionally different thalamocortical circuits...
  25. pmc Mediodorsal thalamic lesions impair trace eyeblink conditioning in the rabbit
    Donald A Powell
    Shirley L Buchanan Neuroscience Laboratory, Dorn VA Medical Center, Columbia, South Carolina 29208, USA
    Learn Mem 9:10-7. 2002
    ..The lesions had no significant effect on the HR CR. These results suggest that information processed by MDN and relayed to the prefrontal cortex is required for somatomotor response selection under nonoptimal learning conditions...
  26. ncbi Postnatal development of the afferent projections from the dorsomedial thalamic nucleus to the frontal cortex in mice
    Oscar Rios
    Departamento de Morfologia, Facultad de Salud, Universidad del Cauca, Popayan, Colombia
    Brain Res Dev Brain Res 150:47-50. 2004
    ..37% vs. the maximal average, P4). After P16, the mean average remains stable up to P60...
  27. ncbi Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 22:7687-94. 2002
    ..The assessment of the effects of cocaine at a time not readily evaluated in humans provides a baseline from which the effects of chronic cocaine exposure can be investigated...
  28. ncbi Thalamic relay nuclei of the basal ganglia form both reciprocal and nonreciprocal cortical connections, linking multiple frontal cortical areas
    Nikolaus R McFarland
    Department of Neurobiology and Anatomy, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 22:8117-32. 2002
    ..Together, these experiments indicate a dual role for VA-VL and MD nuclei: (1) to relay basal ganglia output within specific cortical circuits and (2) to mediate information flow between cortical circuits...
  29. ncbi Parallel pain processing in freely moving rats revealed by distributed neuron recording
    Jin Yan Wang
    Neuroscience Research Institute and Department of Neurobiology, Peking University Health Science Center, 100083, Beijing, PR China
    Brain Res 992:263-71. 2003
    ..The results provide an initial demonstration of distributed activity patterns within different pain systems in awake and freely moving rats, hence, providing confirmation of the existence of the dual pain pathways...
  30. ncbi What the brain stem tells the frontal cortex. I. Oculomotor signals sent from superior colliculus to frontal eye field via mediodorsal thalamus
    Marc A Sommer
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892 4435, USA
    J Neurophysiol 91:1381-402. 2004
    ..We hypothesize that a major signal conveyed by the pathway is corollary discharge information about the vector of impending saccades...
  31. ncbi Magnetic resonance imaging of mediodorsal, pulvinar, and centromedian nuclei of the thalamus in patients with schizophrenia
    Eileen M Kemether
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Gen Psychiatry 60:983-91. 2003
    ..The centromedian nucleus (CMN), important in attention and arousal, has not been previously studied with MRI...
  32. ncbi N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy
    C Brandt
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559 Hannover, Germany
    Neuroscience 118:727-40. 2003
    ..E. is an effective means to reduce the damage produced by a sustained S.E. in several brain regions, including the hippocampus, but show that this partial neuroprotection of the limbic system does not prevent the development of epilepsy...
  33. ncbi Neuroimaging communality between schizophrenia and obsessive compulsive disorder: a putative basis for schizo-obsessive disorder?
    Ruth Gross-Isseroff
    Outpatient Department, Geha Mental Health Center, P O Box 102, Petach Tikva 49100, Israel
    World J Biol Psychiatry 4:129-34. 2003
    ..studies: the caudate nucleus, the orbitofrontal cortex, the anterior cingulate gyrus and the mediodorsal thalamic nucleus. The present review describes the neuroimaging studies on schizophrenia, pertaining to these brain ..
  34. ncbi Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury
    William L Maxwell
    Laboratory of Human Anatomy, Thomson Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Brain 127:2470-8. 2004
    ..In severely disabled and vegetative patients, loss of neurons from the ventral posterior thalamic nucleus may also reflect loss of response to afferent stimuli...
  35. ncbi Absence of memory dysfunction after bilateral mammillary body and mammillothalamic tract electrode implantation: preliminary experience in three patients
    Thierry P Duprez
    AJNR Am J Neuroradiol 26:195-7; author reply 197-8. 2005
  36. pmc Visual perception and corollary discharge
    Marc A Sommer
    Department of Neuroscience and the Center for the Neural Basis of Cognition, University of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
    Perception 37:408-18. 2008
    ....
  37. ncbi Structural and functional characteristics of the dorsomedial nucleus of the cerebral amygdaloid complex in male rats
    A V Akhmadeyev
    Department of Human and Animal Morphology and Physiology, Bashkir State University, Ufa
    Bull Exp Biol Med 143:488-9. 2007
    ..We developed a classification of neuroendocrine neurons of the dorsomedial nucleus of the cerebral amigdaloid complex of male rats; characteristics of these cells are presented...
  38. ncbi High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo
    Clinton B McCracken
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 27:12601-10. 2007
    ..Moreover, selective potentiation of input to these inhibitory circuits may also contribute to the therapeutic effects produced by DBS in OCD patients...
  39. pmc Neurotoxic lesions of the medial mediodorsal nucleus of the thalamus disrupt reinforcer devaluation effects in rhesus monkeys
    Anna S Mitchell
    Department of Experimental Psychology, Oxford University, Oxford OX1 3UD, United Kingdom
    J Neurosci 27:11289-95. 2007
    ..This finding suggests that the neural circuitry for control of behavioral choice by changes in reinforcer value includes MDmc...
  40. ncbi Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat
    Walter B Hoover
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
    Brain Struct Funct 212:149-79. 2007
    ....
  41. ncbi Prefrontal projections to the thalamic reticular nucleus form a unique circuit for attentional mechanisms
    Basilis Zikopoulos
    Department of Health Sciences, Boston University, Boston, Massachusetts 02215, USA
    J Neurosci 26:7348-61. 2006
    ..The targeting of sensory tiers of TRN by specific prefrontal areas may underlie attentional regulation for the selection of relevant sensory signals and suppression of distractors...
  42. ncbi Abnormalities of thalamic activation and cognition in schizophrenia
    Jessica Andrews
    Department of Anatomy and Neurobiology, Washington University, St Louis, MO 63130, USA
    Am J Psychiatry 163:463-9. 2006
    ....
  43. pmc Projections from bed nuclei of the stria terminalis, anteromedial area: cerebral hemisphere integration of neuroendocrine, autonomic, and behavioral aspects of energy balance
    Hong Wei Dong
    Department of Biological Sciences, University of Southern California, Los Angeles, 90089 2520, USA
    J Comp Neurol 494:142-78. 2006
    ....
  44. ncbi Functional mapping of the cardiorespiratory effects of dorsal and median raphe nuclei in the rat
    R M Alvarenga
    Programa de Pós Graduação em Ciências Fisiológicas, Centro Biomedico, Universidade Federal do Espirito Santo, Vitoria, ES, Brazil
    Braz J Med Biol Res 38:1719-27. 2005
    ....
  45. ncbi Diminished feeding responsiveness to orexin A (hypocretin 1) in aged rats is accompanied by decreased neuronal activation
    Catherine M Kotz
    Veterans Affairs Medical Center, GRECC 11G, One Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Regul Integr Comp Physiol 289:R359-R366. 2005
    ..Orexin A did not elevate c-Fos-ir in 3-mo-old rats at 2 h after injection, whereas the PVN and mediodorsal thalamic nucleus (MD) showed elevated c-Fos-ir at 2 h in 24-mo-old rats...
  46. ncbi Differential modulation of anterior cingulate cortical activity by afferents from ventral tegmental area and mediodorsal thalamus
    Shao Pii Onn
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    Eur J Neurosci 21:2975-92. 2005
    ....
  47. ncbi Distinct roles of oxidative stress and antioxidants in the nucleus dorsalis and red nucleus following spinal cord hemisection
    Mei Xu
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Brain Res 1055:137-42. 2005
    ..These results suggest that oxidative stress is involved in the degeneration of the lesioned ND neurons; whereas constitutive antioxidant enzymes may protect the RN neurons from oxidative damage...
  48. ncbi Volume, neuron density and total neuron number in five subcortical regions in schizophrenia
    Pawel Kreczmanski
    Department of Psychiatry and Neuropsychology, Division of Cellular Neuroscience, Maastricht University, Maastricht, The Netherlands
    Brain 130:678-92. 2007
    ....
  49. ncbi Metabolic disconnection between the mediodorsal nucleus of the thalamus and cortical Brodmann's areas of the left hemisphere in schizophrenia
    Serge A Mitelman
    Department of Psychiatry, Neuroscience PET Laboratory, Box 1505, Mount Sinai Medical Center, One Gustave L Levy Place, New York, NY 10029, USA
    Am J Psychiatry 162:1733-5. 2005
    ..The authors' goal was to examine interregional correlations of thalamocortical metabolic activity during a verbal learning task in schizophrenia...
  50. ncbi A postmortem study of the mediodorsal nucleus of the thalamus in schizophrenia
    T J Cullen
    Department of Clinical Neurology Neuropathology, University of Oxford, Radcliffe Infirmary, OX2 6HE, Oxford, UK
    Schizophr Res 60:157-66. 2003
    ..Hence our negative observations, in the largest sample yet investigated, cast doubt on the robustness and/or the generalisability of MD neuropathology in schizophrenia...
  51. ncbi The TRH neuron: a hypothalamic integrator of energy metabolism
    Ronald M Lechan
    Tupper Research Institute and Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Tufts New England Medical Center, Boston, MA 02111, USA
    Prog Brain Res 153:209-35. 2006
    ....
  52. ncbi Brain and sense organ anatomy and histology of two species of phyletically basal non-Antarctic thornfishes of the Antarctic suborder Notothenioidei (Perciformes: Bovichtidae)
    Joseph T Eastman
    Department of Biomedical Sciences, College of Osteopathic Medicine, Ohio University, Athens, Ohio 45701 2979, USA
    J Morphol 268:485-503. 2007
    ..We conclude that this environment does not require sensory or neural morphology or capabilities beyond those provided by the basic perciform body plan...
  53. ncbi Changes in gamma-aminobutyric acid, mu-opioid and neurotensin receptors in the accumbens-pallidal projection after discrete quinolinic acid lesions in the nucleus accumbens
    L Churchill
    Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, College of Veterinary Medicine, Washington State University, Pullman 99164
    Brain Res 511:41-54. 1990
    ..Fluoro-gold retrograde tracer histochemistry confirmed the specific projection from the dorsomedial core to the dorsal ventral pallidum; and from the shell of the nucleus accumbens to more ventral regions of the ventral pallidum...
  54. ncbi [A case of left dorsomedial thalamic infarction with unilateral schizophrenia-like auditory hallucinations]
    Yukihiro Yoshida
    Department of Neuropsychiatry, Hakodate Watanabe Hospital
    Seishin Shinkeigaku Zasshi 108:31-41. 2006
    ..This possibility might also shed light on the neurological basis of schizophrenia...
  55. ncbi Connections of a motor cortical region in zebra finches: relation to pathways for vocal learning
    S W Bottjer
    University of Southern California, Los Angeles, California 90089 2520, USA
    J Comp Neurol 420:244-60. 2000
    ....
  56. ncbi Distribution, regulation and role of hypothalamic galanin systems: renewed interest in a pleiotropic peptide family
    A L Gundlach
    The University of Melbourne, Department of Medicine, Austin, Victoria, Australia
    Clin Exp Pharmacol Physiol 28:100-5. 2001
    ....
  57. ncbi ACTH- and alpha-MSH-induced grooming, stretching, yawning and penile erection in male rats: site of action in the brain and role of melanocortin receptors
    A Argiolas
    Bernard B Brodie Department of Neuroscience, Cagliari University, Cagliari, Italy
    Brain Res Bull 51:425-31. 2000
    ..The results show that ACTH(1-24) and alpha-MSH act in the hypothalamic periventricular region to induce the above responses and that grooming, stretching and yawning, but not penile erection, are mediated by melanocortin 4 receptors...
  58. ncbi Opioid precursor gene expression in the human hypothalamus
    R R Sukhov
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Comp Neurol 353:604-22. 1995
    ..abstract truncated at 400 words)..
  59. ncbi Axonal connections of the medial magnocellular nucleus of the anterior neostriatum in zebra finches
    E F Foster
    Department of Biology, University of Southern California, Los Angeles 90089 2520, USA
    J Comp Neurol 382:364-81. 1997
    ....
  60. ncbi Cognitive and brain function in schizotypal personality disorder
    Larry J Siever
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Schizophr Res 54:157-67. 2002
    ..Preliminary trials of catecholaminergic agents suggest that these agents may be able to improve these impaired cognitive functions...
  61. ncbi Localization and dynamic regulation of biogenic amine transporters in the mammalian central nervous system
    B J Hoffman
    Unit on Molecular Pharmacology, National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Front Neuroendocrinol 19:187-231. 1998
    ..An understanding of the regulation of transporter function may have important therapeutic consequences for neuroendocrine function in stress and psychiatric disorders...
  62. pmc Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat
    S J Krajewski
    Department of Pathology, University of Arizona College of Medicine, Tucson, AZ, USA
    Neuroscience 166:680-97. 2010
    ..This circuitry provides a mechanism for bilateral synchronization of arcuate NKB/kisspeptin/dynorphin neurons to modulate the pulsatile secretion of GnRH...
  63. ncbi Connections of the medial posterior parietal cortex (area 7m) in the monkey
    G R Leichnetz
    Department of Anatomy, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298 0709, USA
    Anat Rec 263:215-36. 2001
    ..the ventrolateral thalamic (VLc) nucleus, lateral posterior thalamic nucleus, lateral pulvinar, caudal mediodorsal thalamic nucleus and medial pulvinar, central lateral, central superior lateral, and central inferior intralaminar ..
  64. ncbi Folic acid in the monkey brain: an immunocytochemical study
    A Mangas
    Gemacbio S A, Immunochemistry Department, Cenon, France
    Neurosci Lett 362:258-61. 2004
    ..The distribution of folic acid-immunoreactive structures in the monkey brain suggests that this vitamin could be involved in several mechanisms, such as visual, auditory, motor and somatosensorial functions...
  65. ncbi Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits
    J Y Li
    Department of Surgery, University of Michigan, Ann Arbor, 48109, USA
    J Neuroendocrinol 17:394-404. 2005
    ..7% (P < 0.05). Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that Asb-4 is a gene involved in energy homeostasis...
  66. ncbi Temporal and spatial expression of preprotachykinin A mRNA in the developing filial mice brain after maternal administration of monosodium glutamate at a late stage of pregnancy
    L Xu
    Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi an Jiaotong University, Department of Physiology and Pathophysiology, Xi an Jiaotong University School of Medicine, Xi an, Shaanxi, China
    Neuroscience 145:974-80. 2007
    ..The present study provides insights into the plasticity and vulnerability of neuron in different brain regions to glutamate excitotoxicity...
  67. ncbi GABA(A) receptor-mediated effects on expression of c-Fos in rat trigeminal nucleus following high- and low-intensity afferent stimulation
    M Takemura
    Department of Oral Anatomy, Osaka University Faculty of Dentistry, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Neuroscience 98:325-32. 2000
    ....
  68. ncbi GABA B receptor-mediated effects on expression of c-Fos in rat trigeminal nucleus following high- and low-intensity afferent stimulation
    M Takemura
    Department of Oral Anatomy, Osaka University Graduate School of Dentistry, 1 8 Yamadaoka, Suita, 565 0871, Osaka, Japan
    Neuroscience 103:1051-8. 2001
    ..Systemic administration of phaclofen could enhance nociceptive sensory activity but not non-nociceptive activity...
  69. ncbi Distribution of GABA(B) receptor protein in somatosensory cortex and thalamus of adult rats and during postnatal development
    A Princivalle
    Department of Neurophysiology, Neurological Institute, Milan, Italy
    Brain Res Bull 52:397-405. 2000
    ....
  70. ncbi Contributions of thalamic nuclei to declarative memory functioning
    Ysbrand D Van Der Werf
    Dept of Psychology, Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Canada
    Cortex 39:1047-62. 2003
    ..The two types of function subserved by these groups of thalamic nuclei, focussing on contents vs. state, need to work in parallel to mediate and allow memory functioning, respectively...
  71. ncbi Differential effects of ascending neurons containing dopamine and noradrenaline in the control of spontaneous activity and of evoked responses in the rat prefrontal cortex
    J Mantz
    Chaire de Neuropharmacologie, INSERM U 114, College de France, Paris
    Neuroscience 27:517-26. 1988
    The medial prefrontal cortex receives converging projections from the mediodorsal thalamic nucleus, dopaminergic cells from the ventral tegmental area dn noradrenergic cells from the locus coeruleus...
  72. ncbi Mapping of somatostatin-28 (1-12) in the alpaca diencephalon
    R Covenas
    Institute of Neurosciences of Castilla y León INCYL, Laboratory of Neuroanatomy of the Peptidergic Systems, Salamanca, Spain
    J Chem Neuroanat 42:89-98. 2011
    ..in the central medial thalamic nucleus, laterodorsal thalamic nucleus, lateral habenular nucleus, mediodorsal thalamic nucleus, paraventricular thalamic nucleus, reuniens thalamic nucleus, rhomboid thalamic nucleus, ..
  73. ncbi Sex differences in serotonergic but not gamma-aminobutyric acidergic (GABA) projections to the rat ventromedial nucleus of the hypothalamus
    Heather B Patisaul
    Department of Zoology, North Carolina State University, Raleigh, North Carolina 27695, USA
    Endocrinology 149:397-408. 2008
    ..The hormone-dependent organization of these 5-HT projection patterns may be an important developmental mechanism accounting for sex-specific behaviors in adulthood...
  74. ncbi Various dietary fats differentially change the gene expression of neuropeptides involved in body weight regulation in rats
    B Dziedzic
    Department of Cell to Cell Communication, Medical University of Lodz, Lodz, Poland
    J Neuroendocrinol 19:364-73. 2007
    ..The present study demonstrates that various forms of dietary fat differentially change the expression of neuropeptide genes involved in energy homeostasis...
  75. ncbi Effects of lateral hypothalamic lesion with the neurotoxin hypocretin-2-saporin on sleep in Long-Evans rats
    D Gerashchenko
    West Roxbury VA Medical Center and Harvard Medical School, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Neuroscience 116:223-35. 2003
    ..These results led us to conclude that the extent of hypocretin neuronal loss together with an accompanying loss of cells in the lateral hypothalamus may explain the differences in severity of symptoms seen in human narcolepsy...
  76. ncbi Nicotinic receptors in the rat prefrontal cortex: increase in glutamate release and facilitation of mediodorsal thalamo-cortical transmission
    Y Gioanni
    INSERM U114, College de France, Paris, France
    Eur J Neurosci 11:18-30. 1999
    ..In the first experiment, rats received a unilateral excitotoxic lesion centred on the mediodorsal thalamic nucleus (MD), and were sacrificed 1 week later...
  77. ncbi Role of nucleus tractus solitarius 5-HT3 receptors in the defense reaction-induced inhibition of the aortic baroreflex in rats
    C Sévoz-Couche
    Institut National de la Sante et de la Recherche Medicale, Unité 288, Faculté de Médecine Pitié Salpêtrière, 75634 Paris Cedex 13, France
    J Neurophysiol 90:2521-30. 2003
    ....
  78. pmc High field FMRI reveals thalamocortical integration of segregated cognitive and emotional processing in mediodorsal and intralaminar thalamic nuclei
    C D Metzger
    Department of Psychiatry, Otto von Guericke University Magdeburg, Germany
    Front Neuroanat 4:138. 2010
    ..We could lend evidence to segregated subcortical loops which integrate cognitive and emotional aspects of basic human behavior such as sexual processing...
  79. ncbi Subcortical projections to the frontal pole in the marmoset monkey
    Kathleen J Burman
    Department of Physiology, Monash University, Clayton, VIC 3800, Australia
    Eur J Neurosci 34:303-19. 2011
    ....
  80. ncbi Organization of human hypothalamus in fetal development
    Yuri Koutcherov
    Prince of Wales Medical Research Institute, Sydney, New South Wales 2031, Australia
    J Comp Neurol 446:301-24. 2002
    ..The use of chemoarchitecture in the human fetus permitted the identification of interspecies nuclei homologies, which otherwise remain concealed in the cytoarchitecture...
  81. ncbi Hypothalamus of the human fetus
    Yuri Koutcherov
    Prince of Wales Medical Research Institute, The University of New South Wales, Barker Street, NSW 2031, Randwick, Australia
    J Chem Neuroanat 26:253-70. 2003
    ....
  82. ncbi ZENK protein regulation by song in the brain of songbirds
    C V Mello
    Laboratory of Animal Behavior, The Rockefeller University, New York, New York 10021, USA
    J Comp Neurol 393:426-38. 1998
    ..Thus, ZENK protein regulation can be used to assess activation of brain areas involved in perceptual and motor aspects of song. Possible implications of ZENK induction in these areas are discussed...
  83. ncbi Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry
    H B Gottlieb
    Department of Pharmacology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Neuroendocrinol 19:531-42. 2007
    ..Together, central opioid receptor-like type 1 activation in these CNS regions may participate in the neural pathways involved in the diuretic and antinatriuretic effects of nociceptin...
  84. ncbi Forebrain connectivity of the prefrontal cortex in the marmoset monkey (Callithrix jacchus): an anterograde and retrograde tract-tracing study
    Angela C Roberts
    Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, CB2 3EB, UK
    J Comp Neurol 502:86-112. 2007
    ..In addition it had extensive connections with limbic regions including the amygdala, parahippocampal cortex, cingulate, and retrosplenial cortex...
  85. ncbi Kisspeptin immunoreactive cells of the ovine preoptic area and arcuate nucleus co-express estrogen receptor alpha
    I Franceschini
    UMR 6175 INRA CNRS UniversityTours Haras Nationaux, IFR 135, 37380 Nouzilly, France
    Neurosci Lett 401:225-30. 2006
    ..The pattern of distribution of kp10 immunoreactivity in the hypothalamus suggests a role for kisspeptin in the estrogen-dependent regulation of GnRH and LH secretion in the ewe...
  86. ncbi Neuropeptide Y and corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob/ob mice respond to food-deprivation and refeeding
    M Jang
    Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824 1224, USA
    J Nutr 128:2520-5. 1998
    ..The hypothalamic concentrations of two neuropeptides involved in body weight regulation (i.e., NPY and CRH) in leptin-deficient ob/ob mice respond abnormally to abrupt changes in nutritional status...
  87. ncbi [Pathology of the thalamus and schizophrenia--an overview]
    P Danos
    Klinik fur Psychiatrie, Psychosomatische Medizin und Psychotherapie der Universitätsklinik Magdeburg
    Fortschr Neurol Psychiatr 72:621-34. 2004
    ..The reviewed data suggest that distinct thalamic nuclei and therefore distinct neuronal circuits are involved in the pathogenesis of schizophrenia...
  88. ncbi Differential response of arcuate proopiomelanocortin- and neuropeptide Y-containing neurons to the lesion produced by gold thioglucose administration
    Akiko Homma
    Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, 183 8526 Tokyo, Japan
    J Comp Neurol 499:120-31. 2006
    ..The present results first demonstrate that POMC- and NPY-containing neurons in the arcuate nucleus respond differently to the lesion produced by the GTG treatment...
  89. ncbi Projections of the dorsomedial nucleus of the intercollicular complex (DM) in relation to respiratory-vocal nuclei in the brainstem of pigeon (Columba livia) and zebra finch (Taeniopygia guttata)
    J M Wild
    Department of Anatomy, School of Medicine, University of Auckland, New Zealand
    J Comp Neurol 377:392-413. 1997
    ..All but the projections to PBvl and XIIts were reciprocal. In summary, the projections of DM suggest that it is able to influence all the key motor and premotor nuclei involved in patterned respiratory-vocal activity...
  90. ncbi Effects of unilateral electrolytic lesion of the dorsomedial nucleus of the hypothalamus on milk-ejection reflex in the rat
    Kazumasa Honda
    Faculty of Nursing and Welfare Sciences, Fukui Prefectural University, Japan
    J Reprod Dev 56:98-102. 2010
    ..OT cells showed milk-ejection burst during ipsilateral suckling but not during contralateral suckling. The results suggest that the unilateral DMH receives information of suckling stimuli applied to contralateral nipples...
  91. pmc Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia
    Stella Dracheva
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, USA
    Brain Res 1214:23-34. 2008
    ..These results provide detailed and quantitative information on iGluR subunit expression in multiple nuclei of the human thalamus but suggest that alterations in their expression are not a prominent feature of schizophrenia...
  92. ncbi Chronic tooth pulp inflammation causes transient and persistent expression of Fos in dynorphin-rich regions of rat brainstem
    M R Byers
    Department of Anesthesiology, University of Washington, Seattle, WA 98195 6540, USA
    Brain Res 861:191-207. 2000
    ..The Fos responses of central neurons to tooth injury have some unusual temporal and spatial patterns in adult rats compared to other trigeminal injury models...
  93. ncbi Serotonin is not synthesized, but specifically transported in the neurons of the hypothalamic dorsomedial nucleus
    S Vanhatalo
    Department of Anatomy, Institute of Biomedicine, University of Helsinki, Finland
    Eur J Neurosci 10:1930-5. 1998
    ....
  94. ncbi Profiles of serotonin receptors in the developing human thalamus
    Maria S M Wai
    School of Biomedical Sciences, Chinese University of Hong Kong, Shatin, N T, Hong Kong, China
    Psychiatry Res 185:238-42. 2011
    ..Disrupted development of the thalamic serotonergic system during this gestational period may contribute to the pathophysiology of neuropsychiatric disorders...
  95. ncbi Architectonics of the thalamus in the echidna (Tachyglossus aculeatus): search for the mediodorsal nucleus
    J Regidor
    Institute of Neurophysiology, School of Medicine, University of Copenhagen, Denmark
    Brain Behav Evol 30:328-41. 1987
    ..Further studies of connections and chemical properties will be essential to determine the degree of correspondence of the presumed 'frontal lobe system' in echidnas to that in other mammals...
  96. ncbi Efferent connections of the rostral linear nucleus of the ventral tegmental area in the rat
    F Del-Fava
    Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, Av Prof Lineu Prestes, 1524, Sao Paulo, SP 05508 900, Brazil
    Neuroscience 145:1059-76. 2007
    ..projections to the magnocellular preoptic nucleus, lateral hypothalamus, central division of the mediodorsal thalamic nucleus, lateral part of the lateral habenula and supraoculomotor region, and light projections to the ..
  97. ncbi Afferent projections to the mediodorsal and anterior thalamic nuclei in the cat. Anatomical-clinical correlations
    J L Velayos
    Faculty of Medicine, Autonomous University of Madrid, Spain
    Brain Pathol 8:549-52. 1998
    ..and NADPH-diaphorase colocation in neuronal bodies which send and receive projections to and from the mediodorsal thalamic nucleus. Based on the connectivity and histochemistry findings, the possibility that prion agents responsible ..
  98. ncbi Leptin-dependent STAT3 phosphorylation in postnatal mouse hypothalamus
    Andrea Frontini
    Institute of Normal Human Morphology, Marche Polytechnic University, Via Tronto 10 A, 60020 Ancona, Italy
    Brain Res 1215:105-15. 2008
    ..These cells did not express mature or immature neuronal or glial markers. Their ultrastructural appearance, though suggestive of differentiating cells, was not conclusive for a specific phenotype...
  99. ncbi Intracerebroventricular galanin-like peptide induces different brain activation compared with galanin
    Catherine B Lawrence
    School of Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, United Kingdom
    Endocrinology 144:3977-84. 2003
    ..Double immunohistochemistry indicated that small cells expressing c-fos in the periventricular hypothalamic region after GALP were astrocytes and not microglia...
  100. ncbi Preferential involvement of the basolateral limbic circuit in an amyotrophic lateral sclerosis patient
    T Takeda
    Eur J Neurol 14:e5-6. 2007
  101. ncbi Stress-induced alterations in catecholamine enzymes gene expression in the hypothalamic dorsomedial nucleus are modulated by caudal brain and not hypothalamic paraventricular nucleus neurons
    Boris Mravec
    Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia
    Brain Res Bull 74:147-54. 2007
    ..The gene expression of tyrosine hydroxylase in DMN is modulated by lower brainstem and/or spinal cord, but not by PVN afferents...

Research Grants62

  1. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    ....
  2. Response properties of hypothalamic MCH neurons
    Anthony N van den Pol; Fiscal Year: 2013
    ..abstract_text> ..
  3. ORGANIZATION OF PREFRONTAL FEEDBACK CIRCUITS
    Helen Barbas; Fiscal Year: 2013
    ..and reduce noise;and the synaptic interaction of the amygdala, posterior orbitofrontal cortex and the mediodorsal thalamic nucleus on the inhibitory thalamic reticular nucleus, which gates signals between the thalamus and cortex, and ..
  4. Neural circuits underlying circadian regulation of behavior and physiology
    Nina Vujovic; Fiscal Year: 2012
    ..abstract_text> ..
  5. Circuitry for circadian rhythms
    Clifford B Saper; Fiscal Year: 2013
    ....
  6. To Feed or Breed? GnIH-3 Stimulates Food Intake in Rats
    Gregory Scott Fraley; Fiscal Year: 2013
    ..Students even have the opportunity to do a small amount of teaching if desired. The majority of students in my laboratory over the last 7 years have been women and/or from under-represented groups. ..
  7. Circuitry of Emotion: Integration in the Orbitofrontal Cortex
    CLARE TIMBIE; Fiscal Year: 2013
    ..The brain regions involved in this circuit include the amygdala, the mediodorsal thalamic nucleus, and posterior orbitofrontal cortex (pOFC), but their synergistic projections and synaptic interactions ..
  8. Defects of subcellular glutamate transporter localization in schizophrenia
    Robert E McCullumsmith; Fiscal Year: 2013
    ..These studies will extend the glutamate hypothesis of schizophrenia beyond the NMDA receptor and provide new substrates for diagnosis and treatment of this often devastating illness. ..
  9. The role of the thalamus in human olfactory processing
    CHRISTINA MARIA ZELANO; Fiscal Year: 2012
    ..During scanning, subjects will smell odors that are either presented alone or paired with stimuli from other modalities, enabling us to test for multimodal olfactory response profiles in the mediodorsal thalamus. ..
  10. HYPOTHALAMIC CONTROL OF PROLACTIN SECRETION
    JAMES VOOGT; Fiscal Year: 2001
    ....
  11. LATERAL LINE PATHWAYS
    ROBERT BOORD; Fiscal Year: 1991
    ....
  12. ANATOMICAL BASIS OF OLFACTORY DISCRIMINATION
    Burton Slotnick; Fiscal Year: 1980
    ..The olfactometer allows for precise control of stimulus parameters and the test environment...
  13. MECHANISMS UNDERLYING LEAD-INDUCED DEPRESSION OF GROWTH
    Paul Hammond; Fiscal Year: 1993
    ..In all studies involving modulators of food consumption, patterns of initiation, duration, and termination of food intake will be continuously monitored using a computerized system...
  14. Role of Ghrelin in the Induction of Anxiogenic Behavior
    PAUL CURRIE; Fiscal Year: 2004
    ..abstract_text> ..
  15. ORGANIZATION OF CIRCADIAN SYSTEMS
    KIM HUHMAN; Fiscal Year: 1999
    ..A better understanding of the principles of SCN efferent functioning may lead to more effective treatments for human disorders in circadian timing. ..
  16. THE MEDIODORSAL THALAMIC NUCLEUS IN SCHIZOPHRENIA
    JOSEPH PIERRI; Fiscal Year: 2002
    ..career development award, the candidate will test the general hypothesis that projection neurons in the mediodorsal thalamic nucleus (MDTN) are abnormal in schizophrenia, and that this abnormality is associated with alterations in the ..
  17. Altered Inhibitory Prefrontal Circuitry in Schizophrenia
    DAVID VOLK; Fiscal Year: 2003
    ..Interestingly, several studies report abnormalities in the mediodorsal thalamic nucleus ( about)TN), a major source of excitatory input to the PFC...
  18. GABA Neurons and Cortical Circuitry in Schizophrenia
    David A Lewis; Fiscal Year: 2010
    ..Together, these studies will provide a comprehensive molecular-and circuit-based accounting of the contribution of abnormalities in GABA neurotransmission to dPFC dysfunction in schizophrenia. ..
  19. NEURONAL MECHANISMS OF FEVER
    Clifford Saper; Fiscal Year: 2009
    ....
  20. 5-Year DTI/MRI Follow-Up in Schizophrenia
    Serge Mitelman; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  21. Neural Substrates of Emotion in Borderline Patients
    Erin Hazlett; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  22. THE NEURAL CIRCUITRY OF SENSORIMOTOR GATING
    Erin Hazlett; Fiscal Year: 2002
    ....
  23. THALAMIC PATHOLOGY IN NEUROPSYCHIATRIC DISORDERS
    Keith Young; Fiscal Year: 2003
    ..The study will provide information about whether there are similar or different thalamic abnormalities in schizophrenia and affective disorders. ..
  24. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  25. HYPOXIA AND CONTROL OF FETAL BREATHING MOVEMENTS
    Brian J Koos; Fiscal Year: 2010
    ..Thus, the proposed studies are directly applicable to the morbidity and mortality of heart and breathing disorders in infants, children, and adults, including prolonged sleep apnea, brain injury, and sudden death. ..
  26. HYPOTHALAMIC HYPOCRETIN PATHWAYS MODULATING FEEDING
    CATHERINE KOTZ; Fiscal Year: 2004
    ....
  27. NEURAL MECHANISMS OF VOCAL LEARNING
    SARAH BOTTJER; Fiscal Year: 2009
    ..abstract_text> ..
  28. Early Exposure to Stimulants as a Risk Factor for Substance Abuse
    Linda J Porrino; Fiscal Year: 2010
    ..abstract_text> ..
  29. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  30. Society for the Study of Ingestive Behavior Annual Meet
    Timothy Moran; Fiscal Year: 2003
    ..abstract_text> ..
  31. Metabolic and Epigenetic Effects of Maternal High Fat Diet in Obesity Prone Rats
    Timothy H Moran; Fiscal Year: 2010
    ..The results of these experiments will enhance our understanding of the etiology of obesity and metabolic disease ultimately allowing the development of rational clinical interventions for such conditions. ..
  32. REGULATION OF MESOLIMBIC DOPAMINE BY ENDOGENOUS COMPOUND
    Peter Kalivas; Fiscal Year: 2003
    ..Furthermore, the anatomical and functional mapping of the motive circuit will provide a basis for interpreting future imaging studies in humans where attempts are made to correlate changes in spatially discrete nuclei. ..
  33. M-CPP/PET IN IMPULSIVE PERSONALITY DISORDERS
    Larry Siever; Fiscal Year: 2001
    ....
  34. TIME DEPENDENT EFFECTS OF ETHANOL ON CEREBRAL METABOLISM
    Linda Porrino; Fiscal Year: 2001
    ..These finding swill contribute to the body of work that supports a concept of tolerance which recognizes that integrated activity among various neural circuits are responsible for the time-dependent effects of ethanol. ..
  35. NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOL
    Linda Porrino; Fiscal Year: 2002
    ....
  36. The Ventral Striatal Network in Emotional Processing
    Suzanne Haber; Fiscal Year: 2002
    ..This unique format, which was very successful at our last meeting, encourages free exchange of ideas to address the question "what is the role of the ventral striatal network in emotional processing? ..
  37. Marine Toxin Impacts on Neurobehavioral Function
    Edward Levin; Fiscal Year: 2003
    ..The forum will provide an opportunity for methodological and theoretical issues to be integrated in the context of each talk as well as in a discussion session at the end of the symposium. ..
  38. DISTRIBUTION AND ULTRASTRUCTURE OF DENTAL INNERVATION
    MARGARET BYERS; Fiscal Year: 2003
    ..Our goal is to understand neuroinflammatory interactions in inflamed teeth in order to develop better treatments for dental pain. ..
  39. Neurofeedback functional MRI
    Seung Schik Yoo; Fiscal Year: 2006
    ....
  40. Dysfunctional Cortico-Limbic Activity and Connectivity in Bipolar Disorder and Li
    Amit Anand; Fiscal Year: 2010
    ..This study will also establish an experimental paradigm to study brain connectivity which could be used to investigate other disorders. ..
  41. SYNAPTIC ORGANIZATION OF THE BASOLATERAL AMYGDALA
    ALEXANDER MCDONALD; Fiscal Year: 2008
    ..abstract_text> ..
  42. Decision Making in Marijuana Users
    Linda Porrino; Fiscal Year: 2009
    ..Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users. ..
  43. TRH and Energy Homeostasis
    RONALD LECHAN; Fiscal Year: 2006
    ..abstract_text> ..
  44. Low Carbohydrate Diets: Feeding and Endocrine Signaling
    Timothy Moran; Fiscal Year: 2006
    ..abstract_text> ..
  45. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  46. Regulation and Development of the Prefrontal Cortex
    Suzanne Haber; Fiscal Year: 2005
    ..A specific emphasis is on recruiting young scientists to the field. Therefore each workshop will engage at least one young scientist in a leadership role, (as facilitator, scribe, or presenter). ..
  47. Nicotinic-Antipsychotic Drug Interactions and Cognition
    Edward Levin; Fiscal Year: 2006
    ..abstract_text> ..
  48. Dopamine system plasticity after a partial lesion
    Suzanne Haber; Fiscal Year: 2005
    ....
  49. Pharmacoresistant limbic epilepsy: model validation
    Edward Bertram; Fiscal Year: 2005
    ..This project will meet the program goals by establishing baseline data and introducing new methods for evaluating the therapeutic potential of novel compounds for the treatment of epilepsy. ..
  50. International Congress of Neuroethology
    SARAH BOTTJER; Fiscal Year: 2004
    ..Thus, benefits to American scientists in general, and to young investigators in particular, will be the opportunity for exposure to cutting-edge research and techniques from around the World. ..
  51. Metabolic Regulation of Reproduction
    GREGORY FRALEY; Fiscal Year: 2006
    ..It is hoped that this basic knowledge will lead to a better understanding of disorders of reproduction that are associated with diabetes and thus provide an enlightened path towards their treatment. ..
  52. Sleep, Circadian Rhythms and Dementing Illnesses
    David Harper; Fiscal Year: 2007
    ..abstract_text> ..
  53. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD LECHAN; Fiscal Year: 2007
    ..abstract_text> ..
  54. Stress-induced reinstatement of cocaine-seeking behavior
    Peter Kalivas; Fiscal Year: 2008
    ..abstract_text> ..
  55. CNS Estrogen Receptors and Social Behavior
    BRUCE CUSHING; Fiscal Year: 2004
    ....
  56. HORMONES AND BEHAVIORAL DEVELOPMENT
    BRUCE CUSHING; Fiscal Year: 2004
    ....
  57. Reward, Compulsions and Habit Formation
    Suzanne Haber; Fiscal Year: 2007
    ..2005; Kelley and Berridge, 2002), as well as the commonalities and differences in other compulsive disorders such as OCD and Tourette's Syndrome. [unreadable] [unreadable] [unreadable]..
  58. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  59. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  60. Nucleus Accumbens-Mediated Feeding: Output Pathways
    Thomas R Stratford; Fiscal Year: 2010
    ....