thalamic nuclei


Summary: Several groups of nuclei in the thalamus that serve as the major relay centers for sensory impulses in the brain.

Top Publications

  1. ncbi Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis
    S Hannoun
    CREATIS, UMR 5220 CNRS and U1044 INSERM, Universite Claude Bernard Lyon1, University of Lyon, France
    AJNR Am J Neuroradiol 33:1363-8. 2012
  2. ncbi Contributions of thalamic nuclei to declarative memory functioning
    Ysbrand D Van Der Werf
    Dept of Psychology, Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Canada
    Cortex 39:1047-62. 2003
  3. ncbi Different mechanisms of secondary neuronal damage in thalamic nuclei after focal cerebral ischemia in rats
    Marcel Dihné
    Department of Neurology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Stroke 33:3006-11. 2002
  4. ncbi The effects of lesions to the anterior thalamic nuclei on object-place associations in rats
    V Sziklas
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Eur J Neurosci 11:559-66. 1999
  5. ncbi The midline thalamus: alterations and a potential role in limbic epilepsy
    E H Bertram
    Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA
    Epilepsia 42:967-78. 2001
  6. ncbi The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
    J P Aggleton
    School of Psychology, University of Wales, College of Cardiff, UK
    Behav Brain Res 81:189-98. 1996
  7. ncbi Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging
    Mette R Wiegell
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 19:391-401. 2003
  8. ncbi Sleep, epilepsy and thalamic reticular inhibitory neurons
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Trends Neurosci 28:317-24. 2005
  9. ncbi Segmentation of thalamic nuclei from DTI using spectral clustering
    Ulas Ziyan
    MIT Computer Science and Artificial Intelligence Lab, Cambridge MA, USA
    Med Image Comput Comput Assist Interv 9:807-14. 2006
  10. ncbi Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei
    Eriko Kuramoto
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Eur J Neurosci 33:95-109. 2011

Research Grants

Detail Information

Publications213 found, 100 shown here

  1. ncbi Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis
    S Hannoun
    CREATIS, UMR 5220 CNRS and U1044 INSERM, Universite Claude Bernard Lyon1, University of Lyon, France
    AJNR Am J Neuroradiol 33:1363-8. 2012
    ..The relationship between diffusivity markers, and atrophy of the caudate and the thalamus, as well as brain lesion load and clinical status of the patients was also explored...
  2. ncbi Contributions of thalamic nuclei to declarative memory functioning
    Ysbrand D Van Der Werf
    Dept of Psychology, Cognitive Neuroscience Unit, Montreal Neurological Institute, McGill University, Montreal, Canada
    Cortex 39:1047-62. 2003
    ..The two types of function subserved by these groups of thalamic nuclei, focussing on contents vs...
  3. ncbi Different mechanisms of secondary neuronal damage in thalamic nuclei after focal cerebral ischemia in rats
    Marcel Dihné
    Department of Neurology, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Stroke 33:3006-11. 2002
    ..In this study differences in secondary damage of the ventroposterior thalamic nucleus (VPN) and the reticular thalamic nucleus (RTN) were investigated with the use of different ischemia models...
  4. ncbi The effects of lesions to the anterior thalamic nuclei on object-place associations in rats
    V Sziklas
    Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada
    Eur J Neurosci 11:559-66. 1999
    ..A third experiment examined the effects of damage to the anterior thalamic nuclei on the eight-arm radial maze, a spatial working memory task...
  5. ncbi The midline thalamus: alterations and a potential role in limbic epilepsy
    E H Bertram
    Department of Neurology, University of Virginia, Charlottesville, Virginia 22908, USA
    Epilepsia 42:967-78. 2001
    ..In this study we examined the midline thalamic regions for involvement in limbic seizures, changes in anatomy and physiology, and the potential role for this region in limbic seizures and epilepsy...
  6. ncbi The effects of selective lesions within the anterior thalamic nuclei on spatial memory in the rat
    J P Aggleton
    School of Psychology, University of Wales, College of Cardiff, UK
    Behav Brain Res 81:189-98. 1996
    ..lesions centred in either the anterior thalamic nucleus (AM), the anterior ventral and anterior dorsal thalamic nuclei (AV/AD), or all three nuclei combined (ANT.T)...
  7. ncbi Automatic segmentation of thalamic nuclei from diffusion tensor magnetic resonance imaging
    Mette R Wiegell
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 13th Street, Room 2301, Charlestown, MA 02129, USA
    Neuroimage 19:391-401. 2003
    ..Here, we show that diffusion tensor magnetic resonance imaging (DTI) can noninvasively resolve the major thalamic nuclei based on the characteristic fiber orientation of the corticothalamic/thalamocortical striations within each ..
  8. ncbi Sleep, epilepsy and thalamic reticular inhibitory neurons
    Mircea Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Trends Neurosci 28:317-24. 2005
  9. ncbi Segmentation of thalamic nuclei from DTI using spectral clustering
    Ulas Ziyan
    MIT Computer Science and Artificial Intelligence Lab, Cambridge MA, USA
    Med Image Comput Comput Assist Interv 9:807-14. 2006
    Recent work shows that diffusion tensor imaging (DTI) can help resolving thalamic nuclei based on the characteristic fiber orientation of the corticothalamic/thalamocortical striations within each nucleus...
  10. ncbi Complementary distribution of glutamatergic cerebellar and GABAergic basal ganglia afferents to the rat motor thalamic nuclei
    Eriko Kuramoto
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Eur J Neurosci 33:95-109. 2011
    Motor thalamic nuclei, ventral anterior (VA), ventral lateral (VL) and ventral medial (VM) nuclei, receive massive glutamatergic and GABAergic afferents from the cerebellum and basal ganglia, respectively...
  11. pmc The subcellular organization of neocortical excitatory connections
    Leopoldo Petreanu
    Janelia Farm Research Campus, Howard Hughes Medical Institute, Ashburn, Virginia 20147, USA
    Nature 457:1142-5. 2009
    ..We expressed ChR2 in two thalamic nuclei, the whisker motor cortex and local excitatory neurons and mapped their synapses with pyramidal neurons in ..
  12. pmc Laminar and modular organization of prefrontal projections to multiple thalamic nuclei
    D Xiao
    Program in Neuroscience, Boston University, Boston, MA 02215, USA
    Neuroscience 161:1067-81. 2009
    The prefrontal cortex projects to many thalamic nuclei, in pathways associated with cognition, emotion, and action...
  13. pmc Functional organization of the thalamic input to the thalamic reticular nucleus
    Ying Wan Lam
    Department of Neurobiology, University of Chicago, Chicago, Illinois 60637, USA
    J Neurosci 31:6791-9. 2011
  14. pmc Simultaneous top-down modulation of the primary somatosensory cortex and thalamic nuclei during active tactile discrimination
    Miguel Pais-Vieira
    Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 33:4076-93. 2013
    ..located in the primary somatosensory cortex (S1), the ventroposterior medial, and the posterior medial thalamic nuclei of the trigeminal somatosensory pathways exhibited prominent anticipatory firing modulations before the ..
  15. ncbi Chronic deep brain stimulation of subthalamic and anterior thalamic nuclei for controlling refractory partial epilepsy
    K J Lee
    Department of Neurosurgery, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Acta Neurochir Suppl 99:87-91. 2006
    ..We intended to describe the results of DBS on subthalamic nuclei and anterior thalamic nuclei (STN and ATN) from our patients and to evaluate the long-term efficiency and safety of DBS for controlling ..
  16. ncbi Segmentation of thalamic nuclei using a modified k-means clustering algorithm and high-resolution quantitative magnetic resonance imaging at 1.5 T
    Sean C L Deoni
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, PO89, De Crespigny Park, Denmark Hill, London, SE5 8AF, UK
    Neuroimage 34:117-26. 2007
    ..In this paper we introduce a method for segmenting the individual thalamic nuclei based on high-resolution quantitative magnetic resonance images, providing improved target visualization...
  17. ncbi Involvement of medial pulvinar thalamic nucleus in human temporal lobe seizures
    Dominique S Rosenberg
    Department of Functional Neurology and Epileptology, Federative Institute of Neurosciences INSERM IFR 19, Bron, France
    Epilepsia 47:98-107. 2006
    ..Considering the rich and reciprocal connectivity of the medial pulvinar (PuM) with the temporal lobe, we evaluated a potential participation of this thalamic nucleus in temporal lobe epilepsy (TLE)...
  18. ncbi Rat intralaminar thalamic nuclei projections to the globus pallidus: a biotinylated dextran amine anterograde tracing study
    T Yasukawa
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Memphis, Memphis, Tennessee 38163, USA
    J Comp Neurol 471:153-67. 2004
    The topographical organization and ultrastructural features of the intralaminar thalamic nuclei (ITN) projections to the globus pallidus (GP) were studied using the biotinylated dextran amine (BDA) anterograde tracing method in the rat...
  19. pmc Effects of mental illness and aging in two thalamic nuclei
    William Byne
    Division of Basic and Laboratory Research, Bronx Veterans Affairs Medical Center, Bronx, NY 10467, United States
    Schizophr Res 106:172-81. 2008
    ..Among subjects with psychiatric diagnoses, exposure to lithium was associated with an increase in the number of oligodendrocytes. No effects were detected for exposure to anticonvulsants or for abuse of alcohol or other substances...
  20. pmc Gbx2 plays an essential but transient role in the formation of thalamic nuclei
    Kairong Li
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, Farmington, United States of America
    PLoS ONE 7:e47111. 2012
    ..The molecular mechanisms underlying the formation of thalamic nuclei remain largely unknown...
  21. ncbi A morphological analysis of thalamocortical axon fibers of rat posterior thalamic nuclei: a single neuron tracing study with viral vectors
    Sachi Ohno
    Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Cereb Cortex 22:2840-57. 2012
    The rostral sector of the posterior thalamic nuclei (POm) is, together with the ventral posterior nuclei (VP), involved in somatosensory information processing in rodents...
  22. ncbi Topographical connections of the substantia nigra pars reticulata to higher-order thalamic nuclei in the rat
    Medine Idrizoglu Gulcebi
    Department of Pharmacology, Marmara University, School of Medicine, Istanbul, Turkey
    Brain Res Bull 87:312-8. 2012
    ..The present study explores whether the SNR relates to all dorsal thalamic nuclei equally or just to a particular group of nuclei, such as first or higher-order nuclei...
  23. ncbi Thalamic nuclei after human blunt head injury
    William L Maxwell
    Department of Anatomy, Division of Neuroscience and Biomedical Systems, University of Glasgow, UK
    J Neuropathol Exp Neurol 65:478-88. 2006
    ..The study provides novel quantitative evidence for differential neuronal loss, with survival after human head injury, from thalamic nuclei associated with different aspects of cortical activation.
  24. pmc Impairments of thalamic nuclei in idiopathic generalized epilepsy revealed by a study combining morphological and functional connectivity MRI
    Zhengge Wang
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China
    PLoS ONE 7:e39701. 2012
    Neuroimaging evidence suggested that the thalamic nuclei may play different roles in the progress of idiopathic generalized epilepsy (IGE)...
  25. ncbi Observation of glucose metabolism in the thalamic nuclei by fusion PET/MRI
    Zang Hee Cho
    Neuroscience Research Institute, Gachon University of Medicine and Science, Incheon, South Korea
    J Nucl Med 52:401-4. 2011
    ..The anatomy of the thalamus and its connectivity with surrounding areas are known. Localized metabolic activities at the thalamic substructural level have not been measured in vivo in human brains because of limited resolution and contrast...
  26. ncbi Self-sustained rhythmic activity in the thalamic reticular nucleus mediated by depolarizing GABAA receptor potentials
    M Bazhenov
    Howard Hughes Medical Institute, Salk Institute, La Jolla, California 92037, USA
    Nat Neurosci 2:168-74. 1999
    ..This model predicts that the isolated reticular nucleus could initiate sequences of spindle oscillations in thalamocortical networks in vivo...
  27. ncbi Change detection by thalamic reticular neurons
    Xiong Jie Yu
    CAS Hong Kong Joint Research Laboratory for Visuo Auditory Integration, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
    Nat Neurosci 12:1165-70. 2009
    ..Deviance detection probably causes TRN neurons to transiently deactivate surrounding TRN neurons in response to a fresh stimulus, altering auditory thalamus responses and inducing attention shift...
  28. ncbi Rat PPAR delta contains a CGG triplet repeat and is prominently expressed in the thalamic nuclei
    G Xing
    Unit on Gene Mapping and Expression, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Biochem Biophys Res Commun 217:1015-25. 1995
    ..These results raise the possibility that PPAR delta might play a role in modulating response to thermal and pain sensations...
  29. ncbi Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus
    Y Nakagawa
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:2711-25. 2001
    ..These genes may also influence the pathfinding and targeting of thalamocortical axons through both cell-autonomous and non-autonomous mechanisms...
  30. ncbi Intrathalamic sensory connections mediated by the thalamic reticular nucleus
    J W Crabtree
    Department of Anatomy, School of Medical Sciences, University of Bristol, UK
    Cell Mol Life Sci 56:683-700. 1999
  31. ncbi Expression of regulatory genes during differentiation of thalamic nuclei in mouse and monkey
    Edward G Jones
    Center for Neuroscience, University of California, Davis, Davis, California 95616, USA
    J Comp Neurol 477:55-80. 2004 mice at birth (P0) and in adulthood, and in fetal monkeys early and late in the period of gestation when thalamic nuclei are becoming histologically differentiated out of a series of pronuclear masses...
  32. ncbi Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements
    R B Lotto
    Genes and Development Group, Department of Biomedical Sciences, University Medical School, Edinburgh EH8 9XD, United Kingdom
    J Neurosci 21:3904-10. 2001
    ..We suggest that the onset of a requirement for cortex-derived neurotrophic factors initiates a competitive mechanism regulating programmed cell death among dorsal thalamic neurons...
  33. ncbi Visualization of thalamic nuclei on high resolution, multi-averaged T1 and T2 maps acquired at 1.5 T
    Sean C L Deoni
    Imaging Research Laboratories, Robarts Research Institute, London, Ontario, Canada
    Hum Brain Mapp 25:353-9. 2005
    ..These results confirm our hypothesis and demonstrate the potential high-resolution quantitative imaging for nucleus visualization and surgical planning...
  34. ncbi Potentiation of local field potentials in the anterior cingulate cortex evoked by the stimulation of the medial thalamic nuclei in rats
    Jen Chuang Kung
    Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan, ROC
    Brain Res 953:37-44. 2002
    ..The potentiation of MT-evoked ACC potentials provides a neural basis for synaptic plasticity, which may be essential for the establishment of pain-initiated conditioning behavior and affective responses to noxious stimuli...
  35. pmc Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei
    William Byne
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, United States
    Schizophr Res 98:118-28. 2008
    ..All markers were differentially expressed across nuclei...
  36. ncbi Thalamic nuclei activity in idiopathic generalized epilepsy: an EEG-fMRI study
    L Tyvaert
    Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    Neurology 73:2018-22. 2009 absence seizures and during spike-and-wave discharges and suggest the involvement of different types of thalamic nuclei. With the development of deep brain stimulation in epilepsy, the role of the thalamic nuclei needs to be ..
  37. pmc Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice
    Tou Yia Vue
    Department of Neuroscience and Stem Cell Institute, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci 29:4484-97. 2009
    ..Nevertheless, how a distinct array of postmitotic thalamic nuclei emerge from this single developmental unit has remained largely unknown...
  38. pmc Guarding the gateway to cortex with attention in visual thalamus
    Kerry McAlonan
    Laboratory of Sensorimotor Research, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 456:391-4. 2008
    ..The reciprocal modulation in LGN and TRN appears only during the initial visual response, but the modulation of LGN reappears later in the response, suggesting separate early and late sources of attentional modulation in LGN...
  39. ncbi Mast cells accumulate in the anogenital region of somatosensory thalamic nuclei during estrus in female mice
    Katalin J Kovács
    Department of Veterinary Biomedical Sciences, University of Minnesota, 1988 Fitch Avenue, Rm 295, St Paul, MN 55108, USA
    Brain Res 1114:85-97. 2006
    ..During estrus, mast cells were especially concentrated in those regions within the VPL and posterior thalamic nuclei that receive somatosensory information from the anogenital region...
  40. ncbi Induction of c-fos in specific thalamic nuclei following stimulation of the pedunculopontine tegmental nucleus
    James A Ainge
    School of Psychology, University of St Andrews, St Andrews, Fife, KY16 9JU, Scotland
    Eur J Neurosci 20:1827-37. 2004
    ..Tracing studies have established that the PPTg has projections to many thalamic nuclei and electrophysiological studies have shown acetylcholine (ACh) to have characteristic effects on thalamic ..
  41. pmc Unique combination of anatomy and physiology in cells of the rat paralaminar thalamic nuclei adjacent to the medial geniculate body
    Philip H Smith
    Department of Anatomy, University of Wisconsin, Medical School Madison, 53706, USA
    J Comp Neurol 496:314-34. 2006
    ..As with the labeled paralaminar cells, parafascicular cells had physiological features distinguishing them from typical thalamic neurons...
  42. ncbi Cortical and collicular inputs to cells in the rat paralaminar thalamic nuclei adjacent to the medial geniculate body
    Philip H Smith
    Department of Anatomy, University of Wisconsin Medical School Madison, Madison, Wisconsin 53706, USA
    J Neurophysiol 98:681-95. 2007
    ..The inhibitory collicular inputs are GABAergic, activate GABA(A) receptors, and terminate on dendrites. Their activation can greatly alter EPSP-generated spike number and timing...
  43. ncbi Differential activation of anterior and midline thalamic nuclei following retrieval of aversively motivated learning tasks
    Y Yasoshima
    Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, 1 2 Yamada oka, Suita 565 0871, Japan
    Neuroscience 146:922-30. 2007
    Two thalamic nuclear groups, the anterior thalamic nuclei (ATN) and midline and intralaminar thalamic complex (MITC) have connections to the prefrontal cortex, amygdala, hippocampus and accumbens that are important for learning and ..
  44. ncbi Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilin
    Sarah M Clinton
    Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Am J Psychiatry 162:1859-71. 2005
    ..In this study, the authors studied this question by measuring in postmortem brain the expression of molecules associated with dopaminergic neurotransmission...
  45. ncbi Multiarchitectonic and stereotactic atlas of the human thalamus
    A Morel
    Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, Switzerland
    J Comp Neurol 387:588-630. 1997
    ..PV), calbindin D-28K (CB), and calretinin (CR) were used as neurochemical markers to further characterize thalamic nuclei and delimit subterritories of functional significance for stereotactic explorations...
  46. ncbi Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamus
    D A Lewis
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Am J Psychiatry 158:1411-22. 2001
    ..The authors tested the hypothesis that schizophrenia is associated with a selective deficit in a marker of thalamic axon terminals in the middle layers of the prefrontal cortex, the primary zone of termination of thalamic axons...
  47. ncbi The differential distribution of the growth-associated protein-43 in first and higher order thalamic nuclei of the adult rat
    S L Feig
    Department of Anatomy, University of Wisconsin School of Medicine, 1300 University Avenue, Madison, WI 53706, USA
    Neuroscience 136:1147-57. 2005
    ..large terminals that make multiple synaptic contacts on proximal dendrites of relay cells in higher order thalamic nuclei and have been termed "driver" inputs...
  48. ncbi Differential effects mediated by GABAA receptors in thalamic nuclei in lh/lh model of absence seizures
    D A Hosford
    Department of Medicine Neurology, Duke University Medical Center Durham, NC, USA
    Epilepsy Res 27:55-65. 1997
    ..Region-specific GABAA receptor isoforms may underlie the contrasting effects of clonazepam after microinjection into NRT and VLa...
  49. ncbi Size gradients of barreloids in the rat thalamus
    S Haidarliu
    Department of Neurobiology, The Weizmann Institute of Science, Rehovot 76100, Israel
    J Comp Neurol 429:372-87. 2001
    ..This implies that the extended representation is not merely a reflection of peripheral innervation biases and probably serves an as yet unknown processing function...
  50. ncbi Attraction exerted in vivo by grafts of embryonic neocortex on developing thalamic axons
    I Frappé
    Departement des Neurosciences, CNRS, UMR 6558, Universite de Poitiers, 86022 Poitiers Cedex, France
    Exp Neurol 169:264-75. 2001
    ..into the occipital cortex of newborn rats receive inputs from the ventrolateral (VL) and ventromedial (VM) thalamic nuclei which, normally, project to the frontal cortex (25)...
  51. pmc Differences in response to serotonergic activation between first and higher order thalamic nuclei
    C Varela
    Department of Neurobiology, The University of Chicago, 947 E 58th Street, Chicago, IL 60637, USA
    Cereb Cortex 19:1776-86. 2009
    Two types of thalamic nuclei have been recognized: first order, which relay information from subcortical sources, and higher order, which may relay information from one cortical area to another...
  52. ncbi Convergent and complementary projections of the caudal paralaminar thalamic nuclei to rat temporal and insular cortex
    R Linke
    Institut fur Anatomie, Otto von Guericke Universitat Magdeburg, D 39120 Magdeburg, Germany
    Cereb Cortex 10:753-71. 2000
    b>Thalamic nuclei adjacent to the medial geniculate body play a pivotal role in processing of sensory stimuli during emotional situations...
  53. ncbi Posterior parietal cortex projections to the ventral lateral and some association thalamic nuclei in Macaca mulatta
    Otar Taktakishvili
    Department of Anatomy and Cell Biology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Brain Res Bull 59:135-50. 2002
    ..The results demonstrate that projections from small loci of the PPC to functionally and connectionally different thalamic nuclei differ anatomically, implying a different functional impact on these diverse targets.
  54. ncbi Postmortem assessment of thalamic nuclear volumes in subjects with schizophrenia
    William Byne
    Department of Psychiatry and Pathology, Mount Sinai School of Medicine, New York, USA
    Am J Psychiatry 159:59-65. 2002
    ..The authors assessed schizophrenia-associated changes in volume and neuronal number in the mediodorsal nucleus and the pulvinar regions of the thalamus...
  55. pmc Cellular dynamics of cholinergically induced alpha (8-13 Hz) rhythms in sensory thalamic nuclei in vitro
    Magor L Lorincz
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Neurosci 28:660-71. 2008
    ..of cholinergic activation on the thalamus and, in combination with previous studies, show that sensory thalamic nuclei possess powerful and dynamically reconfigurable mechanisms for generating synchronized alpha activity that ..
  56. pmc Ablation of Kv3.1 and Kv3.3 potassium channels disrupts thalamocortical oscillations in vitro and in vivo
    Felipe Espinosa
    Departments of Neuroscience and Psychiatry, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9111, USA
    J Neurosci 28:5570-81. 2008
    ..The results support the hypothesis that altered electrophysiological properties of TRN neurons contribute to the reduced EEG power at slow frequencies in the thalamocortical network of Kv3-deficient mice...
  57. ncbi Synaptic plasticity in thalamic nuclei enhanced by motor skill training in rat with transient middle cerebral artery occlusion
    Yuchuan Ding
    Department of Neurological Surgery, Wayne State University School of Medicine, Lande Medical Research Building, Room 48, 550 E Canfield, Detroit, MI 48201, USA
    Neurol Res 25:189-94. 2003
    ..In treadmill-trained animals, however, similarly intense synaptic plasticity in these two thalamic nuclei was seen only at 28 days...
  58. ncbi Differential responses in three thalamic nuclei in moderately disabled, severely disabled and vegetative patients after blunt head injury
    William L Maxwell
    Laboratory of Human Anatomy, Thomson Building, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK
    Brain 127:2470-8. 2004
    ..analysis of changes in numbers of neurons within the dorsomedial, ventral posterior and lateral posterior thalamic nuclei in patients assessed by the Glasgow Outcome Scale as moderately disabled (n = 9), severely disabled (n = 12) ..
  59. ncbi Midline and intralaminar thalamic connections with the orbital and medial prefrontal networks in macaque monkeys
    David T Hsu
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 504:89-111. 2007
    Although the midline and intralaminar thalamic nuclei (MITN) were long believed to project "nonspecifically," they are now known from rat studies to have restricted connections to the prefrontal cortex...
  60. pmc Feedforward inhibitory control of sensory information in higher-order thalamic nuclei
    Philippe Lavallée
    Centre de Recherche, Université Laval Robert Giffard, Hôpital Robert Giffard, Quebec, G1J 2G3, Canada
    J Neurosci 25:7489-98. 2005
    ..Instead, we propose that this pathway operates through disinhibition, and that the posterior group forwards to the cerebral cortex sensory information that is contingent on motor instructions...
  61. ncbi A possible role of the thalamus in some cases of sudden unexpected death in epilepsy
    Fulvio A Scorza
    Epilepsia 48:1036-7. 2007
  62. ncbi Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems
    Pei Juan Shen
    Howard Florey Institute, The University of Melbourne, Victoria 3010, Australia
    Ann N Y Acad Sci 1041:510-5. 2005
  63. ncbi Comparison of oculomotor neuronal activity in paralaminar and mediodorsal thalamus in the rhesus monkey
    Ikuo Tanibuchi
    Department of Physiology, Shiga University of Medical Science, Seta tsukinowa cho, Ohtsu, Shiga 520 2192, Japan
    J Neurophysiol 93:614-9. 2005
    ..In the course of mapping the dorsal thalamus, we also studied neurons in a subset of thalamic nuclei (the caudal part of the ventral lateral nucleus (VLc), the oral part of the ventral posterior lateral nucleus ..
  64. ncbi Differential projection of the posterior paralaminar thalamic nuclei to the amygdaloid complex in the rat
    R Linke
    Institut fur Anatomie, Otto von Guericke Universitat, Magdeburg, Germany
    Exp Brain Res 134:520-32. 2000
    ..Each of these thalamic nuclei receives a unique pattern of afferent input but an unresolved question is, how each of these thalamic nuclei ..
  65. ncbi Organization of projections of rat retrosplenial cortex to the anterior thalamic nuclei
    H Shibata
    Department of Veterinary Anatomy, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Japan
    Eur J Neurosci 10:3210-9. 1998
    The organization of the projections from the retrosplenial cortex (Brodmann's area 29) to the anterior thalamic nuclei was examined in the rat with retrograde transport of the cholera toxin B subunit and anterograde transport of ..
  66. ncbi Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia
    R E Smith
    Department of Psychiatry Mental Health Research Institute, University of Michigan Medical School, Ann Arbor 48109 0720, USA
    Am J Psychiatry 158:1393-9. 2001
  67. ncbi Lesions of specific and nonspecific thalamic nuclei affect prefrontal cortex-dependent aspects of spatial working memory
    Kathleen R Bailey
    Department of Psychology, University of New Hampshire, Durham, NH 03824, USA
    Behav Neurosci 119:410-9. 2005
    ..lesions of specific mediodorsal (MD) and nonspecific midline/intralaminar (M/IL) and ventromedial (VM) thalamic nuclei placed to spare the anterior nuclei...
  68. ncbi GABA affinity shapes IPSCs in thalamic nuclei
    Claude M Schofield
    Department of Neurology and Neurological Sciences, Stanford University, Stanford, California 94305, USA
    J Neurosci 27:7954-62. 2007
    ..These results indicate that within thalamic circuits, a powerful diversity of inhibitory function can result from simple differences in underlying GABA(A) receptor affinity...
  69. ncbi Zona incerta: Substrate for contralateral interconnectivity in the thalamus of rats
    B D Power
    Department of Anatomy and Histology, University of Sydney, 2006 Sydney, Australia
    J Comp Neurol 436:52-63. 2001
    ..the different ZI sectors (rostral, dorsal, ventral, and caudal) and into intralaminar and higher order dorsal thalamic nuclei of Sprague-Dawley rats by using stereotaxic coordinates...
  70. pmc Nociceptive stimulation activates locus coeruleus neurones projecting to the somatosensory thalamus in the rat
    D L Voisin
    Inserm E216 Neurobiologie de la douleur trigéminale, Faculte de Chirurgie Dentaire, 11 Boulevard Charles de Gaulle, 63000 Clermont Ferrand, France
    J Physiol 566:929-37. 2005
    ..For the first time, it is shown that nociceptive stimulation activates LC neurones projecting to the somatosensory thalamus. This suggests a new role for LC in modulating nociception within the thalamus...
  71. ncbi Do nociceptive signals from the pancreas travel in the dorsal column?
    A K Houghton
    Department of Anatomy and Neurosciences, Marine Biomedical Institute, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 1069, USA
    Pain 89:207-20. 2001
    ..However, the dorsal column pathway may not be the sole route for relaying information about noxious stimulation of the pancreas, particularly that impacting complex behavioral responses...
  72. pmc Higher-order thalamic relays burst more than first-order relays
    E J Ramcharan
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, 777 Glades Road, Boca Raton, FL 33431, USA
    Proc Natl Acad Sci U S A 102:12236-41. 2005
    ..If bursting effectively signals the introduction of new information to a cortical area, as suggested, this increased bursting may be more important in corticocortical transmission than in transmission of primary information to cortex...
  73. ncbi Cerebellar thalamic activity in the macaque monkey encodes the duration but not the force or velocity of wrist movement
    J J Ivanusic
    School of Medical Sciences, The University of New South Wales, Sydney, New South Wales 2052, Australia
    Brain Res 1041:181-97. 2005
  74. ncbi Taste pathways that mediate accumbens dopamine release by sapid sucrose
    Andras Hajnal
    Department of Neural and Behavioral Sciences H181, The Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
    Physiol Behav 84:363-9. 2005
    ..168+/-9% for sham operated controls; p<0.02). This represents the first demonstration that the affective character of a sensory stimulus might separate from the thalamocortical system as early as the second central synapse...
  75. ncbi Thalamocortical connections in the pond turtle Pseudemys scripta elegans
    Dantong Zhu
    Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, 414 E Clark St, Vermillion, SD 57069, USA
    Brain Behav Evol 65:278-92. 2005
    ..Injections of neurobiotin into these thalamic nuclei confirmed the projections to the cortex...
  76. ncbi A maternal blood-borne factor promotes survival of the developing thalamus
    Peter Landgraf
    Institute of Physiology, Otto von Guericke University, Magdeburg, Germany
    FASEB J 19:225-7. 2005
    ..e., optic nerve crush), which points to a potential role of the factor not only in neuronal development but also in neuroinflammation after white matter injury...
  77. ncbi The trajectory of sensory pathways from the lamina terminalis to the insular and cingulate cortex: a neuroanatomical framework for the generation of thirst
    Jacob H Hollis
    Department of Physiology, Monash University, Victoria, Australia
    Am J Physiol Regul Integr Comp Physiol 294:R1390-401. 2008
    ..had increased numbers of Fos/CTb double-positive neurons in the paraventricular, rhomboid, and reuniens thalamic nuclei, whereas those rats injected with CTb in the cingulate cortex and challenged with hypertonic saline had ..
  78. ncbi A quantitative map of the circuit of cat primary visual cortex
    Tom Binzegger
    Institute of Neuroinformatics, University of Zurich, and Eidgenössische Technische Hochschule Zürich, CH 8057 Zurich, Switzerland
    J Neurosci 24:8441-53. 2004
    ..The map of the whole cortical circuit shows that there are very few "strong" but many "weak" excitatory projections, each of which may involve only a few percentage of the total complement of excitatory synapses of a single neuron...
  79. ncbi Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels
    D Kim
    National Creative Research Initiative Center, for Calcium and Learning, Department of Life Science, Pohang University of Science and Technology, 790 784, Pohang, South Korea
    Neuron 31:35-45. 2001
    ..Thus, the modulation of the intrinsic firing pattern mediated by alpha(1G) T-type Ca(2+) channels plays a critical role in the genesis of absence seizures in the thalamocortical pathway...
  80. ncbi Spikes and bursts in two types of thalamic projection neurons differentially shape sleep patterns and auditory responses in a songbird
    Richard H R Hahnloser
    Institute of Neuroinformatics, University of Zurich Swiss Federal Institute of Technology Zurich, 8057 Zurich, Switzerland
    J Neurosci 28:5040-52. 2008
    ..Our results reveal that cerebral sleep-burst epochs and arousal-related burst suppression are both shaped by sophisticated polysynaptic thalamic mechanisms...
  81. pmc FMRI of brain activation in a genetic rat model of absence seizures
    Jeffrey R Tenney
    Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Epilepsia 45:576-82. 2004
    ..EEG-triggered functional magnetic resonance imaging (fMRI) was used to identify areas of brain activation during spontaneous spike-and-wave discharges (SWDs) in an epileptic rat strain under awake conditions...
  82. ncbi Orexin (hypocretin) innervation of the paraventricular nucleus of the thalamus
    Gilbert J Kirouac
    Division of Basic Medical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland and Labrador, Canada
    Brain Res 1059:179-88. 2005 describe the extent of orexin fiber innervation of the PVT in comparison to other midline and intralaminar thalamic nuclei and to establish the location and proportion of orexin neurons innervating the PVT...
  83. ncbi Timing of ascending and descending visual signals predicts the response mode of single cells in the thalamic nucleus rotundus of the pigeon (Columba livia)
    Kristian Folta
    Institute for Cognitive Neuroscience, Department of Biopsychology, Faculty of Psychology, Ruhr University Bochum, D 44780 Bochum, Germany
    Brain Res 1132:100-9. 2007
    ..These effects might become mediated by intratectal mechanisms, the nucleus ventrolateralis thalami, or the bed nuclei of the tectothalamic tract and might constitute the neural basis of a bihemispheric gating function...
  84. ncbi Visual presentation of phobic stimuli: amygdala activation via an extrageniculostriate pathway?
    Liesbet Goossens
    Department of Psychiatry and Neuropsychology, Maastricht University, Maastricht, The Netherlands
    Psychiatry Res 155:113-20. 2007
    ..Moreover, the thalamus findings support the involvement of an extrageniculostriate pathway in the process of phobic fear...
  85. pmc Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis
    Catherine Kielar
    Pediatric Storage Disorders Laboratory, Box P040, MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, De Crespigny Park, King s College London, London, SE5 8AF, UK
    Neurobiol Dis 25:150-62. 2007
    ..loss occurred only late in disease progression but were preceded by localized astrocytosis within individual thalamic nuclei and the progressive loss of thalamic neurons that relay different sensory modalities to the cortex...
  86. ncbi Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: implications for abnormal motor behavior
    V Anaya-Martinez
    Departamento de Fisiologia, Biofisica y Neurociencias, CINVESTAV, Apartado Postal 14 740, Mexico D F, 07000 Mexico
    Neuroscience 143:477-86. 2006
    ..The fact that lesion of a single dopaminergic neuron can reduce dopamine transmission in more than one structure is probably important in generating the manifestations of Parkinson's disease...
  87. ncbi Different topography of the reticulothalmic inputs to first- and higher-order somatosensory thalamic relays revealed using photostimulation
    Ying Wan Lam
    Department of Neurobiology, University of Chicago, IL 60637, USA
    J Neurophysiol 98:2903-9. 2007
  88. ncbi Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus: potential roles in synchronization and sensation
    Charlotte Deleuze
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:8633-45. 2006
  89. ncbi Mapping of the functional interconnections between thalamic reticular neurons using photostimulation
    Ying Wan Lam
    Department of Neurobiology, Pharmacology and Physiology, Univ of Chicago, 947 E 58th St, MC 0926, 316 Abbott, Chicago, IL 60637, USA
    J Neurophysiol 96:2593-600. 2006
  90. pmc Nucleus- and species-specific properties of the slow (<1 Hz) sleep oscillation in thalamocortical neurons
    L Zhu
    School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3US, UK
    Neuroscience 141:621-36. 2006 of this oscillation and compare them with those observed in thalamocortical neurons of three other thalamic nuclei in the cat (ventrobasal complex, medial geniculate body; ventral lateral nucleus) and two thalamic nuclei in ..
  91. ncbi Properties of tactile responses of neurons in rat thalamic ventroposterolateral nucleus
    Jing Bai
    Shanghai Institute of Brain Functional Genomics, the Key Laboratories of Ministry of Education of China, East China Normal University, Shanghai 200062, China
    Neurosci Bull 23:300-6. 2007
    ..To determine whether the convergences of tactile information also occur at thalamic ventroposterolateral nucleus in rats, we investigated the properties of tactile responses of the thalamic ventroposterolateral nucleus in rats...
  92. pmc Heterogeneous output pathways link the anterior pretectal nucleus with the zona incerta and the thalamus in rat
    Kristóf Giber
    Department of Cellular and Network Neurobiology, Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, 1083 Hungary
    J Comp Neurol 506:122-40. 2008
    ..parvalbumin-positive, ventral part of the ZI, which contains ZI neurons with axons projecting to higher order thalamic nuclei. The APT-ZI pathway consisted of both gamma-aminobutyric acid (GABA)-negative and GABA-positive components; ..
  93. ncbi Cortical, callosal, and thalamic connections from primary somatosensory cortex in the naked mole-rat (Heterocephalus glaber), with special emphasis on the connectivity of the incisor representation
    Erin C Henry
    Neuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee 37235, USA
    Anat Rec A Discov Mol Cell Evol Biol 288:626-45. 2006
  94. ncbi Imaging the neural substrates involved in the genesis of pentylenetetrazol-induced seizures
    Mathew E Brevard
    Center for Comparative NeuroImaging, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA mathew brevard umassmed edu
    Epilepsia 47:745-54. 2006
  95. ncbi Reciprocal inhibitory connections and network synchrony in the mammalian thalamus
    M M Huntsman
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford University, Stanford, CA 94305, USA
    Science 283:541-3. 1999
    ..In addition, oscillatory synchrony was dramatically intensified. Thus, recurrent inhibitory connections within reticular nucleus act as "desynchronizers."..
  96. ncbi Dynamic GABA(A) receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations
    Vikaas S Sohal
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5122, USA
    J Neurosci 23:3649-57. 2003
    ..These results not only identify a particular anatomical and molecular target for anti-absence drug design, but also elucidate a specific dynamic mechanism by which inhibitory networks control neural oscillations...
  97. ncbi Tonotopic control of auditory thalamus frequency tuning by reticular thalamic neurons
    Nathalie Cotillon-Williams
    Laboratoire de Neurobiologie de l Apprentissage, de la Memoire et de la Communication, UMR 8620 CNRS, Universite Paris Sud, Batiment 446, Orsay, France
    J Neurophysiol 99:1137-51. 2008
    ..25 octaves; they never occurred for larger distances. This relationship indicates that the functional interactions between TRN cells and ventral MG cells rely on precise topographic connections...
  98. pmc Intracellular activity of cortical and thalamic neurones during high-voltage rhythmic spike discharge in Long-Evans rats in vivo
    Pierre Olivier Polack
    Institut national de la santé et de la recherche médicale U667, College de France, 11 place Marcelin Berthelot, 75231 Paris Cedex 05, France
    J Physiol 571:461-76. 2006
    ..Thus, the present study provides an additional support to the hypothesis that HVRS activity in Long-Evans rats is an absence-like seizure activity...
  99. ncbi Coding of stimulus frequency by latency in thalamic networks through the interplay of GABAB-mediated feedback and stimulus shape
    David Golomb
    Center for Theoretical Biological Physics, Ben Gurion University of the Negev, PO Box 653, Beer Sheva 84105, Israel
    J Neurophysiol 95:1735-50. 2006
    ..We suggest that GABAB-mediated inhibition is a substrate of temporal coding in normal brain function...
  100. ncbi Cortical contribution to sensory volleys recorded at thalamic nuclei of lemniscal and paralemniscal pathways
    Ewa Kublik
    Department of Neurophysiology, Nencki Institute of Experimental Biology, 3 Pasteur St, 02 093 Warsaw, Poland
    Acta Neurobiol Exp (Wars) 63:377-82. 2003
    ..The latencies and amplitudes of EPs recorded at both nuclei were not significantly different, which might be attributed to urethane anesthesia...
  101. ncbi Sleep oscillations developing into seizures in corticothalamic systems
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, Quebec, Canada G1K 7P4
    Epilepsia 44:9-20. 2003
    ..5-2.5 Hz, often associated with fast runs at 10-15 Hz, as in the Lennox-Gastaut syndrome...

Research Grants63

  1. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..The gating properties of thalamic nuclei, including the dLGN, result from the concerted integration of the intrinsic properties of thalamic neurons, ..
  2. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..The gating properties of thalamic nuclei, including the dLGN, result from the concerted integration of the intrinsic properties of thalamic neurons, ..
  3. Parafascicular Nucleus: Its Role in Cortical and Striatal Salience Encoding
    Catherine A Thorn; Fiscal Year: 2013
    ..In the mouse, lateral and medial Pf are homologous to the CM (sensorimotor) and Pf (associative) thalamic nuclei of primates, respectively...
  4. Pathophysiology of Dystonia
    Mark S Baron; Fiscal Year: 2013
    ..the relationship between abnormally patterned multi-neuronal discharge activity in single basal ganglia and thalamic nuclei and the motor manifestations of dystonia, SA 2...
  5. Segmentation and volumetric quantification of thalamic nuclei for assessing MS
    Jerry L Prince; Fiscal Year: 2013
    ..having specific physical connections within the brain, it may be possible to relate physical changes in thalamic nuclei caused by MS to specific cognitive, behavioral, or disease subtype differences...
    Vivien A Casagrande; Fiscal Year: 2013
    ..Our specific thesis for this proposal is that all thalamic nuclei contain some cell groups that act as drivers and some that act as modulators for multiple cortical areas, ..
  7. Synaptic Integration in Neurons of the Thalamic Reticular Nucleus
    Michael Beierlein; Fiscal Year: 2013
    ..In turn, they form powerful inhibitory connections with relay cells in several dorsal thalamic nuclei. TRN neuronal output is regulated by networks of local GABAergic synapses as well as by a system of ..
    DENNIS D O'LEARY; Fiscal Year: 2013
    ..investigate the influence of cortex-intrinsic genetic changes to area patterning on the principal sensory thalamic nuclei that relay sensory input to cortex, and define mechanisms of reverse plasticity that serve to systems-match ..
  9. Ensemble Dynamics of Cortical Feedback to the Thalamus
    Dwayne W Godwin; Fiscal Year: 2010 extensive reentry of processed data from Layer 6 of cortex to lower processing levels in sensory thalamic nuclei such as the lateral geniculate nucleus (LGN)...
    Terrence Stanford; Fiscal Year: 2009
    ..The proposed studies will be the first to examine the potential importance of central thalamic nuclei, and the subcortical-cortical interactions they mediate, to the cognitive control of goal-directed saccadic ..
  11. Maladaptive plasticity following spinal cord injury
    Asaf Keller; Fiscal Year: 2010
    ..We also demonstrated that the activity of PO, and related thalamic nuclei, is tightly regulated by inhibitory inputs from the zona incerta and the anterior pretectal .nucleus...
    Richard Harlan; Fiscal Year: 2003
    ..Rich in mu opiate receptors, the midline-intralaminar thalamic nuclei regulate affective responses to visceral stimuli, relaying this information to specific regions of the ..
    ..Specifically these changes will be determined in the ventral anterior, ventral medial and ventral lateral thalamic nuclei after 3 different combinations of lesions (SNr, EPN, and SNr + EPN)...
    Robert Mair; Fiscal Year: 2002
    ..In contrast Korsakoff's disease and similar amnesia result presumably from damage to thalamic nuclei. The previous 10-years of this project have shown that in a rodent model of thiamine-deficiency amnesia (..
    Charles Wilson; Fiscal Year: 1990
    ..the extent to which different populations of corticostriatal neurons recieve synaptic input from ventral thalamic nuclei, contralateral motor and premotor cortex, and axon collaterals of pyramidal tract neurons...
    Igor Ilinsky; Fiscal Year: 1999
    ..Moreover, the same data will provide insights for the manner in which thalamic nuclei may contribute to "cognition" and/or "mental" activities within the context of complex behavior, both normal ..
  17. Functional organization of auditory corticothalamic projection systems
    Daniel Llano; Fiscal Year: 2007
    ..with layer 5 auditory corticothalamic projections providing feedforward driving input to the nonlemniscal thalamic nuclei while layer 6 corticothalamic projections provide feedback to all areas of the auditory thalamus...
    RAINER GUILLERY; Fiscal Year: 2000
    ..outcomes of these experiments will show the extent to which single cells in the association or higher order thalamic nuclei may receive their major "drive" from more than one source, either from two different cortical areas or from ..
    Jeremy Coplan; Fiscal Year: 2003
    ..Our primary focus is that prefrontal cortical efferents, either directly or via thalamic nuclei efferents, utilize the glutamate neurotransmitter system and are hypothesized to be a primary source for ..
  20. Functional relationships between visual cortex and thalamus
    S Murray Sherman; Fiscal Year: 2013
    ..interactions in both directions in the visual system, concentrating on cortical areas V1 and V2 and thalamic nuclei LGN and LP. We then propose to develop in vivo preparations to test hypotheses from the in vitro work...
    ARIEL DEUTCH; Fiscal Year: 2004
    The thalamic paraventricular nucleus (PVT) has generally been considered as one of the non-specific thalamic nuclei. More recent data indicate there is a high degree of specificity in the efferent projections of the PVT and argue against ..
    Kathleen Rockland; Fiscal Year: 1999 comparison with other major cortically-linked centers, such as the basal ganglia and the specific sensory thalamic nuclei. In this project, we will use high resolution serial axon reconstruction and neuron analysis to test and ..
  23. Circuitry of Midbrain Dopamine in Sleep & Wake
    David Rye; Fiscal Year: 2005
    ..e., the thalamic pacemaker) thalamic nuclei. S.A...
  24. Impact of Thalamic Impulses On Awake Neocortex
    HARVEY SWADLOW; Fiscal Year: 2005
    ..The individual neurons of thalamic nuclei operate in two distinct modes: "relay" mode and "burst" mode...
  25. Ascending Pathways for the Periaqueductal Gray
    David Hsu; Fiscal Year: 2004
    ..The PAG projects extensively to the midline/intralaminar thalamic nuclei (ILN), which represents one likely pathway through which the PAG may influence cortical function...
    DOUGLAS FROST; Fiscal Year: 1990
    1) Permanent ectopic retinal projections to auditory or somatosensory thalamic nuclei can be reliably produced by neurosurgery on newborn Syrian hamsters...
  27. Behavioral Correlates of Head Direction Cell Activity
    Russell Frohardt; Fiscal Year: 2003
    The research proposed here employs single-unit recording of "head- direction" (HD) neurons in the anterodersal thalamic nuclei and post- subiculum of freely moving rats...
    SAMUEL SHERMAN; Fiscal Year: 2004
    ..the effects of more complex behaviors on the activity of the LGN relay and to extend these studies to other thalamic nuclei. Over the period of the last grant we have provided evidence that refutes the idea that the LON acts as a ..
    Jeffrey Lieberman; Fiscal Year: 2004
    ..and increasing subarachnoid space and decreasing lH-NAA in mesiotemporal and prefrontal cortical regions and thalamic nuclei) will be observed in a subgroup of patients with poor clinical outcomes reflected by recurrent or persistent ..
    MARTHA BICKFORD; Fiscal Year: 1999
    ..type II cortical terminals supplant the position occupied by primary sensory afferents in the "specific" thalamic nuclei. In separate experiments in vitro slice preparations, intracellular recordings of pulvinar/LP cells will be ..
  31. The role of the pulvinar in visual attention
    KENNETH BRITTEN; Fiscal Year: 2007
    The pulvinar nucleus of the thalamus is one of the most enigmatic structures in the brain. Of thalamic nuclei, it shows the largest increase in size with evolution, keeping pace with the size of primate neocortex...
    DAVID RUGGIERO; Fiscal Year: 2000
    ..the cerebral cortex through projections from the nucleus of the solitary (NTS) tract to midline-intralaminar thalamic nuclei (MIT), where they may be widely distributed to cortex and basal ganglia...
  33. Mapping the Deaf Auditory Cortex
    JOHN BELLIVEAU; Fiscal Year: 2006
    ..The measured cortical activations could reflect reorganization of the thalamic nuclei, and/or plasticity in thalamo-cortical as well as in cortico-cortical connections...
    Kelly Botteron; Fiscal Year: 2000
    ..temporal lobe, prefrontal cortex, parahippocampal gyrus, hippocampus, amygdala, caudate, lenticular and thalamic nuclei. This investigation will advance our understanding of frontal-limbic structural development in the presence ..
    Steven Grant; Fiscal Year: 1991 ascending reticular activating system that modulate the behavioral state of an animal via projections to thalamic nuclei. However, the activity patterns of LDT and PPT neurons, which constitute direct evidence on these issues, are ..
  36. Thalamic Innervation of the Monkey Striatum
    Dinesh Raju; Fiscal Year: 2006
    ..of the thalamostriatal projection, which arises from the ventral anterior (VA) and ventral lateral (VL) motor thalamic nuclei using tract tracing, confocal microscopy, and immunocytochemical electron microscopy techniques...
  37. Feed-foward Inhibition and Thalamocortical Processing
    Jason Trageser; Fiscal Year: 2004
    b>Thalamic nuclei are thought to either transmit information from periphery to cortex ("first order nuclei") or between cortical areas ("higher order nuclei")...
    Mircea Steriade; Fiscal Year: 2001
    ..The potential impact of this study for the modeling community is therefore broad, from models of information processing to the simulations of pathological states, such as epilepsy. ..
  39. Pharmacoresistant limbic epilepsy: model validation
    Edward Bertram; Fiscal Year: 2005
    ..This project will meet the program goals by establishing baseline data and introducing new methods for evaluating the therapeutic potential of novel compounds for the treatment of epilepsy. ..
    RICHARD NORTHCUTT; Fiscal Year: 2005
    ..To test the hypothesis that retinoic acid acts as a signal to pattern endoderm directly during gastrulation (aim 3), presumptive pharyngeal endoderm will be excised, exposed to retinoic acid, and cultured. ..
  41. Mechanisms by which T-type calcium channels increase seizure susceptibility
    Edward Perez Reyes; Fiscal Year: 2010
    ..The studies will likely have a clinical impact: showing that T-channel antagonists reverse the effects of Cav3.2 variants on dendritic development, thereby providing the rationale for their early use to cure epilepsy. ..
    Edward Jones; Fiscal Year: 2004
    Edward Jones; Fiscal Year: 2003
    ..Defective maturation may be a concomitant of or a basis for certain forms of seizures in young individuals. ..
  44. Collicular influence on auditory thalamic neurons
    Philip Smith; Fiscal Year: 2009
    ..Here 1) in contrast to other sensory thalamic nuclei, the ascending synaptic information is in the form of both excitation and inhibition 2) this ascending ..
  45. Development of High Throughput Assays for N-type Calcium Channels
    Edward Perez Reyes; Fiscal Year: 2007
    ..By targeting an important protein in the pain pathway, the research funded by this grant will provide tools that can be used to screen candidate compounds during the development of novel analgesics. [unreadable] [unreadable] [unreadable]..
    Sue Aicher; Fiscal Year: 2007
    ..This collaborative project provides a unique opportunity to directly address structural and physiological questions regarding NTS neuronal function in both the normal and hypertensive states. [unreadable] [unreadable]..
  47. Ethanol, neurotrophins, and thalamocortical matching
    SANDRA MOONEY; Fiscal Year: 2006
    ..abstract_text> ..
    Edward Perez Reyes; Fiscal Year: 2007
    ..Lead compounds will be sent to the NIH Anticonvulsant Drug Development Program for in vivo testing. These studies will test the hypothesis that more potent channel blockers are better antiepileptics and the importance of selectivity. ..
  49. Dynamics of Large Scale Cortical Networks
    Steven Bressler; Fiscal Year: 2006
    ..abstract_text> ..
    JOHN HARTING; Fiscal Year: 2001
    ..Rls in CM-Pf come from the cortex, and share the major synaptic relationships of primary afferents in other thalamic nuclei, we will have a strong argument for changing contemporary views regarding the functions of the CM-Pf (and ..
  51. Neural Mechanisms of Inhibitory Classical Conditioning
    John Freeman; Fiscal Year: 2007
    ..The results of these studies may also lead to a better understanding of the functional pathology associated with various psychiatric disorders that involve deficits in behavioral inhibition. ..
    Lorin Freedman; Fiscal Year: 2003
    ..Activities are outlined over a five-year period that will provide the Principal Investigator a unique opportunity to develop as a research scientist and help to insure his success in academic neurology. ..
    HENRY RALSTON; Fiscal Year: 2003
    ..The overall goal is the understanding of the changes that occur following injury, so that new methods of therapy can be developed to address these changes. ..
  54. Motor Function and Cognitive Decline in Aging Primates
    HENRYK URBANSKI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  55. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    ..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
    Douglas O Frost; Fiscal Year: 2010
    ..Thus, our results can aid in the design of new therapies that improve clinical outcomes. ..
  57. The dynamics of rapsyn in vitro and in vivo
    Emile Bruneau; Fiscal Year: 2007
    ..By investigating the behavior of these proteins we may therefore be able to define new avenues for the development of therapies for neuromuscular disease. [unreadable] [unreadable]..
  58. Experience-Dependent Plasticity of Neocortical Inhibitory Networks
    QIANQUAN SUN; Fiscal Year: 2010
    ..This information could have implications for developing novel treatment strategies for developmental neurological and psychiatric disorders that result from aberrant connectivity among neocortical principal neurons and interneurons. ..
  59. CaMKI, Apoptosis and Cholinergic Neurons in Aging and AD
    Changiz Geula; Fiscal Year: 2007
    ..They will also form the basis of more comprehensive future studies aimed at determining the causes and effects of the alterations of the above genes. [unreadable] [unreadable] [unreadable]..
  60. Neural Substrates of Emotion in Borderline Patients
    Erin Hazlett; Fiscal Year: 2008
    ..unreadable] [unreadable]..
    Elliott Mufson; Fiscal Year: 2008
    ..Finally the program will provide a broad-base of knowledge on neurodegenerative disorders as well as other instruction important for enhancing the interpersonal and professional skills of our trainees. ..
  62. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..