thalamus

Summary

Summary: Paired bodies containing mostly gray substance and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.

Top Publications

  1. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
  2. ncbi Characterization and propagation of uncertainty in diffusion-weighted MR imaging
    T E J Behrens
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Oxford, UK
    Magn Reson Med 50:1077-88. 2003
  3. ncbi Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
    T E J Behrens
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 6:750-7. 2003
  4. ncbi Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutations
    Marjan E Steenweg
    VU University Medical Centre, De Boelelaan 1117, Amsterdam, The Netherlands
    Brain 135:1387-94. 2012
  5. ncbi The cortico-basal ganglia integrative network: the role of the thalamus
    Suzanne N Haber
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA suzanne
    Brain Res Bull 78:69-74. 2009
  6. ncbi Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus
    V Pencea
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 21:6706-17. 2001
  7. pmc Stimulus-specific adaptation in the auditory thalamus of the anesthetized rat
    Flora M Antunes
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute of Neuroscience of Castilla y Leon, University of Salamanca, Salamanca, Spain
    PLoS ONE 5:e14071. 2010
  8. ncbi Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis
    Sônia Batista
    Department of Neurology, Coimbra University Hospitals, Coimbra, Portugal
    J Neurol 259:139-46. 2012
  9. ncbi Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus
    Heidi Johansen-Berg
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Cereb Cortex 15:31-9. 2005
  10. pmc Intrinsic functional relations between human cerebral cortex and thalamus
    Dongyang Zhang
    Washington University, Department of Radiology, Campus Box 8225, 510 South Kingshighway Blvd, St Louis, MO 63110, USA
    J Neurophysiol 100:1740-8. 2008

Detail Information

Publications339 found, 100 shown here

  1. pmc Resting-state functional connectivity in major depression: abnormally increased contributions from subgenual cingulate cortex and thalamus
    Michael D Greicius
    Department of Neurology and Neurological Sciences, Stanford University Medical Center, Stanford, California 94305 5235, USA
    Biol Psychiatry 62:429-37. 2007
    ..The goal of this study was to examine resting-state, default-mode network functional connectivity in subjects with major depression and in healthy controls...
  2. ncbi Characterization and propagation of uncertainty in diffusion-weighted MR imaging
    T E J Behrens
    Oxford Centre for Functional Magnetic Resonance Imaging of the Brain FMRIB, Oxford, UK
    Magn Reson Med 50:1077-88. 2003
    ..This technique is then applied to the estimation of the cortical connectivity of the human thalamus. The resulting connectivity distributions correspond well with predictions from invasive tracer methods in ..
  3. ncbi Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging
    T E J Behrens
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Nat Neurosci 6:750-7. 2003
    ..Here we identified specific connections between human thalamus and cortex using a novel probabilistic tractography algorithm with diffusion imaging data...
  4. ncbi Leukoencephalopathy with thalamus and brainstem involvement and high lactate 'LTBL' caused by EARS2 mutations
    Marjan E Steenweg
    VU University Medical Centre, De Boelelaan 1117, Amsterdam, The Netherlands
    Brain 135:1387-94. 2012
    ..This new neurological disease, early-onset leukoencephalopathy with thalamus and brainstem involvement and high lactate, is hallmarked by unique magnetic resonance imaging features, defined ..
  5. ncbi The cortico-basal ganglia integrative network: the role of the thalamus
    Suzanne N Haber
    Department of Pharmacology and Physiology, University of Rochester School of Medicine, 601 Elmwood Avenue, Rochester, NY 14642, USA suzanne
    Brain Res Bull 78:69-74. 2009
    The thalamus is a critical component of the frontal cortical-basal ganglia-thalamic circuits that mediate motivation and emotional drive, planning and cognition for the development and expression of goal-directed behaviors...
  6. ncbi Infusion of brain-derived neurotrophic factor into the lateral ventricle of the adult rat leads to new neurons in the parenchyma of the striatum, septum, thalamus, and hypothalamus
    V Pencea
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 21:6706-17. 2001
    ..parenchymal structures lining the lateral and third ventricles, including the striatum and septum, as well as the thalamus and hypothalamus, in which neurogenesis had never been demonstrated previously during adulthood...
  7. pmc Stimulus-specific adaptation in the auditory thalamus of the anesthetized rat
    Flora M Antunes
    Auditory Neurophysiology Unit, Laboratory for the Neurobiology of Hearing, Institute of Neuroscience of Castilla y Leon, University of Salamanca, Salamanca, Spain
    PLoS ONE 5:e14071. 2010
    ..057 octaves), revealing evidence of hyperacuity in neurons at a subcortical level. Thus, SSA is expressed strongly in the rat auditory thalamus and contribute significantly to auditory change detection.
  8. ncbi Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis
    Sônia Batista
    Department of Neurology, Coimbra University Hospitals, Coimbra, Portugal
    J Neurol 259:139-46. 2012
    ..Basal ganglia, thalamus and neocortex are thought to have a key role for efficient information-processing, yet the specific relative ..
  9. ncbi Functional-anatomical validation and individual variation of diffusion tractography-based segmentation of the human thalamus
    Heidi Johansen-Berg
    Centre for Functional Magnetic Resonance Imaging of the Brain, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DU, UK
    Cereb Cortex 15:31-9. 2005
    Parcellation of the human thalamus based on cortical connectivity information inferred from non-invasive diffusion-weighted images identifies sub-regions that we have proposed correspond to nuclei...
  10. pmc Intrinsic functional relations between human cerebral cortex and thalamus
    Dongyang Zhang
    Washington University, Department of Radiology, Campus Box 8225, 510 South Kingshighway Blvd, St Louis, MO 63110, USA
    J Neurophysiol 100:1740-8. 2008
    ..The role of the thalamus in this intrinsic activity is unknown despite its critical role in the function of the cerebral cortex...
  11. pmc GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol
    D Chandra
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 103:15230-5. 2006
    ..The GABAA-R alpha4 subunit is expressed at high levels in the dentate gyrus and thalamus and is suspected to contribute to extrasynaptic GABAA-R-mediated tonic inhibition...
  12. pmc Closed-loop optogenetic control of thalamus as a tool for interrupting seizures after cortical injury
    Jeanne T Paz
    Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, California, USA
    Nat Neurosci 16:64-70. 2013
    ..In rats, we found that the thalamus, a structure that is remote from, but connected to, the injured cortex, was required to maintain cortical ..
  13. ncbi Fgf8 controls regional identity in the developing thalamus
    Ayane Kataoka
    RIKEN Brain Science Institute, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Development 135:2873-81. 2008
    The vertebrate thalamus contains multiple sensory nuclei and serves as a relay station to receive sensory information and project to corresponding cortical areas...
  14. ncbi LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain
    Marta B Wisniewska
    International Institute of Molecular and Cell Biology, 02 109 Warsaw, Poland
    J Neurosci 30:4957-69. 2010
    ..that in the adult mouse brain, beta-catenin and LEF1 accumulate in the nuclei of neurons specifically in the thalamus. The particular electrophysiological properties of thalamic neurons depend on T-type calcium channels. Cav3...
  15. ncbi Modeling sleep and wakefulness in the thalamocortical system
    Sean Hill
    Department of Psychiatry, University of Wisconsin Madison, 6001 Research Park Boulevard, Madison, WI 53719 1176, USA
    J Neurophysiol 93:1671-98. 2005
    ....
  16. ncbi Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking
    Morgan H James
    Neurobiology of Addiction Laboratory, School of Biomedical Sciences and Pharmacy and the Centre for Brain and Mental Health Research, University of Newcastle and the Hunter Medical Research Institute, Newcastle, NSW, Australia
    Int J Neuropsychopharmacol 14:684-90. 2011
    ..Two candidate brain regions are the paraventricular thalamus (PVT) and ventral tegmental area (VTA)...
  17. ncbi Nerve fiber impairment of anterior thalamocortical circuitry in juvenile myoclonic epilepsy
    M Deppe
    Department of Neurology, University of Muenster, Albert Schweitzer Str 33, 48129 Muenster, Germany
    Neurology 71:1981-5. 2008
    ..Juvenile myoclonic epilepsy (JME) is a syndrome of idiopathic generalized epilepsy (IGE) without structural brain abnormalities detectable by MRI or CT...
  18. pmc Differential activity of Wnt/beta-catenin signaling in the embryonic mouse thalamus
    Krista K Bluske
    Department of Neuroscience, and Graduate Program in Neuroscience, Minneapolis, Minnesota 55455, USA
    Dev Dyn 238:3297-309. 2009
    In neural development, several Wnt genes are expressed in the vertebrate diencephalon, including the thalamus. However, roles of Wnt signaling in the thalamus during neurogenesis are not well understood...
  19. ncbi Cortical focus drives widespread corticothalamic networks during spontaneous absence seizures in rats
    Hanneke K M Meeren
    Department of Comparative and Physiological Psychology, Nijmegen Institute of Cognition and Information, University of Nijmegen, 6500 HE Nijmegen, The Netherlands
    J Neurosci 22:1480-95. 2002
    ..However, during the first 500 msec, the cortical focus was consistently found to lead the thalamus. These findings argue against the existence of one common subcortical pacemaker for the generation of generalized ..
  20. ncbi Chronic back pain is associated with decreased prefrontal and thalamic gray matter density
    A Vania Apkarian
    Department of Physiology and Institute of Neuroscience, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 24:10410-5. 2004
    ..Gray matter density was reduced in bilateral dorsolateral prefrontal cortex and right thalamus and was strongly related to pain characteristics in a pattern distinct for neuropathic and non-neuropathic CBP...
  21. ncbi A novel single-cell staining procedure performed in vivo under electrophysiological control: morpho-functional features of juxtacellularly labeled thalamic cells and other central neurons with biocytin or Neurobiotin
    D Pinault
    Université Laval Centre de Recherche en Neurobiologie Hôpital de l Enfant Jésus, Quebec, Canada
    J Neurosci Methods 65:113-36. 1996
    ..project to restricted regions of a single thalamic nucleus, including anterior thalamic nuclei, and that the thalamus and Rt complex have reciprocal connections...
  22. pmc Building a bridal chamber: development of the thalamus
    Steffen Scholpp
    Karlsruhe Institute of Technology, Institute for Toxicology and Genetics, 76021 Karlsruhe, Germany
    Trends Neurosci 33:373-80. 2010
    The thalamus is a central brain region that plays a crucial role in distributing incoming sensory information to appropriate regions of the cortex...
  23. ncbi Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
    H R Parri
    School of Biosciences, Cardiff University, Museum Avenue, PO Box 911, Cardiff, CF10 3US, Wales, UK
    Nat Neurosci 4:803-12. 2001
    ..These findings show that astrocytes in situ can act as a primary source for generating neuronal activity in the mammalian central nervous system...
  24. ncbi Internal dynamics determine the cortical response to thalamic stimulation
    Jason N MacLean
    Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Neuron 48:811-23. 2005
    ..Our data demonstrate that precise spatiotemporal activity patterns can be triggered by thalamic inputs and indicate that the thalamus serves to release intrinsic cortical dynamics.
  25. ncbi The effect of enterovirus 71 immunization on neuropathogenesis and protein expression profiles in the thalamus of infected rhesus neonates
    Huicheng Chen
    Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, Yunnan 650118, PR China
    Virology 432:417-26. 2012
    ....
  26. ncbi Short-term depression at thalamocortical synapses contributes to rapid adaptation of cortical sensory responses in vivo
    Sooyoung Chung
    Department of Biology and, Volen Center for Complex Systems, Brandeis University, Mailstop 008, 415 South Street, Waltham, MA 02454, USA
    Neuron 34:437-46. 2002
    ..Extracellular recordings in the somatosensory thalamus revealed that part of the adaptation occurs subcortically, but because cortical adaptation is stronger and ..
  27. ncbi Differential activities of Sonic hedgehog mediated by Gli transcription factors define distinct neuronal subtypes in the dorsal thalamus
    Kazue Hashimoto-Torii
    Division of Morphogenesis, Department of Embryogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University, Honjo 2 2 1, Kumamoto 860 0811, Japan
    Mech Dev 120:1097-111. 2003
    The dorsal thalamus (DT) is a pivotal region in the vertebrate brain that relays inputs from the peripheral sensory organs to higher cognitive centers. It consists of clusters of neurons with relevant functions, called brain nuclei...
  28. pmc Slits are chemorepellents endogenous to hypothalamus and steer thalamocortical axons into ventral telencephalon
    Janet E Braisted
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, CA 92037, USA
    Cereb Cortex 19:i144-51. 2009
    Thalamocortical axons (TCAs) originate in dorsal thalamus, extend ventrally along the lateral thalamic surface, and as they approach hypothalamus make a lateral turn into ventral telencephalon...
  29. ncbi Vascular syndromes of the thalamus
    Jeremy D Schmahmann
    Department of Neurology, VBK 915, Massachusetts General Hospital, Fruit St, Boston, MA 02114, USA
    Stroke 34:2264-78. 2003
    ..This article reviews the anatomy, connections, and functions of the thalamic nuclei, their vascular supply, and the clinical syndromes that result from thalamic infarction...
  30. pmc Profound desensitization by ambient GABA limits activation of δ-containing GABAA receptors during spillover
    Damian P Bright
    Biophysics Section, Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK
    J Neurosci 31:753-63. 2011
    ..Together, our results demonstrate that phasic spillover and tonic inhibition reflect the activation of distinct receptor populations...
  31. ncbi Corticothalamic resonance, states of vigilance and mentation
    M Steriade
    Laboratoire de Neurophysiologie, Faculte de Medecine, Universite Laval, G1K 7P4, Quebec, Canada
    Neuroscience 101:243-76. 2000
    ..of vigilance, brain oscillations are grouped together through reciprocal connections between the neocortex and thalamus. The coherent activity in corticothalamic networks, under the control of brainstem and forebrain modulatory ..
  32. ncbi Synaptic basis for intense thalamocortical activation of feedforward inhibitory cells in neocortex
    Scott J Cruikshank
    Department of Neuroscience, Division of Biology and Medicine, Box G LN, Brown University, Providence, Rhode Island 02912, USA
    Nat Neurosci 10:462-8. 2007
    The thalamus provides fundamental input to the neocortex. This input activates inhibitory interneurons more strongly than excitatory neurons, triggering powerful feedforward inhibition...
  33. ncbi Hedgehog signalling from the zona limitans intrathalamica orchestrates patterning of the zebrafish diencephalon
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, King s College London, Guy s Campus, London SE1 1UL, UK
    Development 133:855-64. 2006
    ..tiggy-winkle hedgehog (twhh), and to development of the forebrain regions that flank the ZLI: the prethalamus and thalamus. We find that enhanced Hh signalling increases the size of prethalamic and thalamic gene expression domains, ..
  34. pmc Inhibition of subliminally primed responses is mediated by the caudate and thalamus: evidence from functional MRI and Huntington's disease
    A R Aron
    Brain Mapping Unit, Department of Psychiatry, University of Cambridge, UK
    Brain 126:713-23. 2003
    ..engaged any ROIs, but the response inhibition process led to significant modulation of both the caudate and thalamus. Taken together, these experiments indicate a causal role for the caudate nucleus and thalamus in automatic ..
  35. ncbi Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes
    Audrey Dufour
    IRIBHM, University of Brussels U L B, 808 Route de Lennik, B 1070 Brussels, Belgium
    Neuron 39:453-65. 2003
    ..Using axon tracing analysis of ephrin/Eph mutant mice, we provide in vivo evidence that Eph receptors in the thalamus and ephrins in the cortex control intra-areal topographic mapping of thalamocortical (TC) axons...
  36. ncbi Consciousness and complexity
    G Tononi
    Neurosciences Institute, 10640 John J Hopkins Drive, San Diego, CA 92121, USA
    Science 282:1846-51. 1998
    ..Applying measures of neural integration and complexity, together with an analysis of extensive neurological data, leads to a testable proposal-the dynamic core hypothesis-about the properties of the neural substrate of consciousness...
  37. pmc Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice
    Libing Zhou
    Developmental Neurobiology, Universite Catholique de Louvain, 1200 Bruxelles, Belgique
    Science 320:946-9. 2008
    ..These observations provide in vivo evidence that Celsr3-mediated interactions between axons and guidepost cells govern axonal tract formation in mammals...
  38. ncbi Bursting of thalamic neurons and states of vigilance
    Rodolfo R Llinas
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York, USA
    J Neurophysiol 95:3297-308. 2006
    ..In addition, thalamocortical activity has been shown to be involved in the genesis of several neuropsychiatric conditions collectively described as thalamocortical dysrhythmia syndrome...
  39. ncbi Men and women are different: diffusion tensor imaging reveals sexual dimorphism in the microstructure of the thalamus, corpus callosum and cingulum
    K Menzler
    Philipps University Marburg, Center of Brain Imaging, Department of Neurology, Marburg, Germany
    Neuroimage 54:2557-62. 2011
    ..In the present study, we used diffusion tensor imaging (DTI) to delineate sex differences of brain white matter...
  40. ncbi Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36
    M R Deans
    Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Neuron 31:477-85. 2001
    ..However, the synchrony of these rhythms was weaker and more spatially restricted in the knockout. We conclude that electrical synapses containing Cx36 are critical for the generation of widespread, synchronous inhibitory activity...
  41. pmc The slow (<1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators
    Vincenzo Crunelli
    School of Biosciences, Cardiff University, Cardiff, UK
    Nat Neurosci 13:9-17. 2010
    ....
  42. pmc Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice
    Tou Yia Vue
    Department of Neuroscience and Stem Cell Institute, University of Minnesota Medical School, University of Minnesota, Minneapolis, MN 55455, USA
    J Neurosci 29:4484-97. 2009
    The mammalian thalamus is located in the diencephalon and is composed of dozens of morphologically and functionally distinct nuclei...
  43. ncbi Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat
    Robert P Vertes
    Center for Complex Systems and Brain Sciences, Florida Atlantic University, Boca Raton, FL 33431, USA
    Neuroscience 142:1-20. 2006
    ..cortex, nucleus accumbens, basolateral nucleus of the amygdala, the mediodorsal and reuniens nuclei of the thalamus and the ventral tegmental area of the midbrain...
  44. ncbi Characterization of progenitor domains in the developing mouse thalamus
    Tou Yia Vue
    Department of Neuroscience, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Comp Neurol 505:73-91. 2007
    ..patterns of various transcription factors and defined progenitor cell populations in the embryonic mouse thalamus. We show that the basic helix-loop-helix (bHLH) transcription factor Olig3 is expressed in the entire thalamic ..
  45. ncbi Deficits of memory, executive functioning and attention following infarction in the thalamus; a study of 22 cases with localised lesions
    Ysbrand D Van Der Werf
    Department of Anatomy and Embryology, Graduate School for Neurosciences Amsterdam, Research Institute Neurosciences Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Neuropsychologia 41:1330-44. 2003
    The thalamus plays a crucial role in memory, executive functioning and attention. It remains, however, unclear whether thalamic structures have specific roles in each of these functions...
  46. ncbi Model of thalamocortical slow-wave sleep oscillations and transitions to activated States
    Maxim Bazhenov
    The Salk Institute, Howard Hughes Medical Institute, Computational Neurobiology Laboratory, La Jolla, California 92037, USA
    J Neurosci 22:8691-704. 2002
    ..The model describes many essential features of SWS and activated states in the thalamocortical system as well as the transition between them...
  47. pmc A cortical motor nucleus drives the basal ganglia-recipient thalamus in singing birds
    Jesse H Goldberg
    McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Neurosci 15:620-7. 2012
    The pallido-recipient thalamus transmits information from the basal ganglia to the cortex and is critical for motor initiation and learning...
  48. pmc Magnetic resonance imaging evidence for presymptomatic change in thalamus and caudate in familial Alzheimer's disease
    Natalie S Ryan
    Dementia Research Centre, Box 16 National Hospital for Neurology and Neurosugery, Queen Square, London WC1N 3BG, UK
    Brain 136:1399-414. 2013
    Amyloid imaging studies of presymptomatic familial Alzheimer's disease have revealed the striatum and thalamus to be the earliest sites of amyloid deposition...
  49. pmc The thalamus and multiple sclerosis: modern views on pathologic, imaging, and clinical aspects
    Alireza Minagar
    Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA, USA
    Neurology 80:210-9. 2013
    ..as well as recent neuropathologic and neuroimaging studies have clearly demonstrated extensive involvement of the thalamus, basal ganglia, and neocortex in patients with MS...
  50. ncbi MRI volumetry of the thalamus in temporal, extratemporal, and idiopathic generalized epilepsy
    Jun Natsume
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute and Hospital, Quebec, Canada
    Neurology 60:1296-300. 2003
    ..To examine the specificity of thalamic atrophy in epilepsy...
  51. pmc Fine frequency tuning in monkey auditory cortex and thalamus
    Edward L Bartlett
    Department of Biomedical Engineering, Johns Hopkins University, 720 Rutland Ave, Traylor 410, Baltimore, MD 21205, USA
    J Neurophysiol 106:849-59. 2011
    ..Fine frequency tuning is also present in 76% of neurons of the auditory thalamus in awake marmosets...
  52. ncbi A comparative analysis of the morphology of corticothalamic projections in mammals
    E M Rouiller
    Institute of Physiology, University of Fribourg, Fribourg, Switzerland
    Brain Res Bull 53:727-41. 2000
    ..terminals are involved in feed-forward projections by which activity from a cortical area is distributed, via the thalamus, to other parts of the cerebral cortex...
  53. ncbi Novel compounds selectively enhance delta subunit containing GABA A receptors and increase tonic currents in thalamus
    K A Wafford
    Department of Molecular and Cellular Neuroscience, Merck Sharp and Dohme Research Laboratories, The Neuroscience Research Centre, Harlow, United Kingdom
    Neuropharmacology 56:182-9. 2009
    ..Recent studies have revealed a tonic form of inhibition in thalamus mediated by the alpha4beta2delta extrasynaptic GABA(A) receptors that may contribute to the regulation of ..
  54. pmc Lhx2 and Lhx9 determine neuronal differentiation and compartition in the caudal forebrain by regulating Wnt signaling
    Daniela Peukert
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Karlsruhe, Germany
    PLoS Biol 9:e1001218. 2011
    ..In the alar plate of the caudal forebrain there are two principal units, the thalamus and the pretectum, each of which is a developmental compartment...
  55. pmc The thalamus and brainstem act as key hubs in alterations of human brain network connectivity induced by mild propofol sedation
    Tommaso Gili
    Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, CF10 3AT, United Kingdom
    J Neurosci 33:4024-31. 2013
    ..mapping of fMRI data in healthy humans under propofol mild sedation demonstrated a decrease of centrality of the thalamus versus an increase of centrality within the pons of the brainstem, highlighting the important role of these two ..
  56. pmc Cognitive and perceptual functions of the visual thalamus
    Yuri B Saalmann
    Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08540, USA
    Neuron 71:209-23. 2011
    The thalamus is classically viewed as passively relaying information to the cortex...
  57. pmc Human pallidothalamic and cerebellothalamic tracts: anatomical basis for functional stereotactic neurosurgery
    Marc N Gallay
    Laboratory for Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zurich, Sternwartstrasse 6, 8091, Zurich, Switzerland
    Brain Struct Funct 212:443-63. 2008
    ..The course of the fibre tracts to the thalamus was traced in the subthalamic region using multiple staining procedures and their entrance into the thalamus ..
  58. ncbi Evidence that juvenile myoclonic epilepsy is a disorder of frontotemporal corticothalamic networks
    Mark D Holmes
    Regional Epilepsy Center, Department of Neurology, University of Washington Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98006, USA
    Neuroimage 49:80-93. 2010
    ..Rather, discharges have both localized onsets and a restricted cortical network during propagation that includes regions of frontal and temporal cortex...
  59. ncbi Antiepileptic effect of electroacupuncture vs. vagus nerve stimulation in the rat thalamus
    Jian Liang Zhang
    School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong
    Neurosci Lett 441:183-7. 2008
    ..anesthesia, extracellular single unit recordings were made from 49 single neurons in the rat ventrobasal (VB) thalamus. The left vagus nerve was stimulated at 30 Hz, 1 or 3 mA for 5 min...
  60. ncbi Thalamic development induced by Shh in the chick embryo
    Claudia Vieira
    Neuroscience Institute, Miguel Hernandez University N 332, Km 87, E 03550 Alicante, Spain
    Dev Biol 284:351-63. 2005
    ..ZLI) is a neuroepithelial domain in the alar plate of the diencephalon which separates the prethalamus from the thalamus. The ZLI has recently been considered to be a possible secondary organizer, effecting its inductions via sonic ..
  61. pmc Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity
    Yongsu Jeong
    Department of Genetic Engineering, College of Life Science and Graduate School of Biotechnology, Kyung Hee University, Yongin si, Gyeonggi Do, Republic of Korea
    Development 138:531-41. 2011
    ..sonic hedgehog (Shh) is expressed in the ventral midline of prosomeres 1-3 (p1-p3), which underlie the pretectum, thalamus and prethalamus, respectively...
  62. ncbi The thalamus and behavior: effects of anatomically distinct strokes
    Emmanuel Carrera
    Department of Neurology, University Hospital, BH 13, 1011 Lausanne CHUV, Switzerland
    Neurology 66:1817-23. 2006
    ....
  63. pmc Transcription factor Gbx2 acts cell-nonautonomously to regulate the formation of lineage-restriction boundaries of the thalamus
    Li Chen
    Department of Genetics and Developmental Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA
    Development 136:1317-26. 2009
    Relatively little is known about the development of the thalamus, especially its differentiation into distinct nuclei. We demonstrate here that Gbx2-expressing cells in mouse diencephalon contribute to the entire thalamic nuclear complex...
  64. ncbi Molecular pathways controlling development of thalamus and hypothalamus: from neural specification to circuit formation
    Seth Blackshaw
    Department of Neuroscience, Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Neurosci 30:14925-30. 2010
    The embryonic diencephalon gives rise to the vertebrate thalamus and hypothalamus, which play essential roles in sensory information processing and control of physiological homeostasis and behavior, respectively...
  65. ncbi Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues
    Julie Seibt
    INSERM U371, 18 Avenue Doyen Lepine, 69675 Bron, France
    Neuron 39:439-52. 2003
    ..Our results thus demonstrate that in parallel to their well-documented proneural function, bHLH transcription factors also contribute to the specification of neuronal connectivity in the mammalian brain...
  66. ncbi Gbx2 expression in the late embryonic chick dorsal thalamus
    Margaret Martinez-de-la-Torre
    Department of Morphological Sciences, University of Murcia, Murcia, Spain
    Brain Res Bull 57:435-8. 2002
    ..sagittal sections discriminated the positions and boundaries of diverse neuronal nuclei belonging to the dorsal thalamus from neighboring territories (the epithalamus, ventral thalamus, pretectum, and the underlying basal plate)...
  67. pmc Topography of thalamic projections requires attractive and repulsive functions of Netrin-1 in the ventral telencephalon
    Ashton W Powell
    Neuroscience Center, Department of Pharmacology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Biol 6:e116. 2008
    ..In accordance with this model, DCC is expressed in a high-rostromedial to low-caudolateral gradient in the dorsal thalamus (DTh), whereas three Unc5 receptors (Unc5A-C) show graded expression in the reverse orientation...
  68. pmc Ethanol modulates synaptic and extrasynaptic GABAA receptors in the thalamus
    Fan Jia
    Department of Anesthesiology, C V Starr Laboratory for Molecular Neuropharmacology, Weill Cornell Medical College, New York, New York 10065, USA
    J Pharmacol Exp Ther 326:475-82. 2008
    ..The thalamus is a brain structure that plays a pivotal role in sleep regulation and rhythmicity...
  69. ncbi Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model
    Yixin Guo
    Department of Mathematics, Drexel University, Philadelphia, PA, USA
    J Neurophysiol 99:1477-92. 2008
    ..Computationally generated inhibitory inputs yielded similar effects on TC relay. These results support the hypothesis that STN-DBS alters parkinsonian GPi activity in a way that may improve TC relay fidelity...
  70. ncbi NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala
    Elizabeth P Bauer
    W M Keck Foundation Laboratory of Neurobiology, Center for Neural Science, New York University, New York, New York 10003, USA
    J Neurosci 22:5239-49. 2002
    ..Collectively, the results suggest that two pharmacologically distinct forms of LTP can be isolated in the LA in vitro and that a combination of both contribute to the formation of fear memories in vivo at the cellular level...
  71. ncbi Region-specific gene expression in early postnatal mouse thalamus
    Kazuya Yuge
    RIKEN Brain Science Institute, Saitama, Japan
    J Comp Neurol 519:544-61. 2011
    Previous studies in the developing mouse thalamus have demonstrated that regional identity is established during early stages of development (Suzuki-Hirano et al. J. Comp. Neurol. 2011;519:528-543)...
  72. pmc Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems
    Jeremy D Schmahmann
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Cortex 44:1037-66. 2008
    ..fibers to contralateral cerebral regions, striatal fibers to basal ganglia, and projection subcortical bundles to thalamus, brainstem and/or pontocerebellar system...
  73. pmc Selective T-type calcium channel block in thalamic neurons reveals channel redundancy and physiological impact of I(T)window
    Fanny M Dreyfus
    Université Pierre et Marie Curie Paris, 6, Paris F 75005, France
    J Neurosci 30:99-109. 2010
    ....
  74. ncbi Surgery of the motor thalamus: problems with the present nomenclatures
    Paul Krack
    Neurology Department, University of Grenoble, Grenoble, France
    Mov Disord 17:S2-8. 2002
    ..Neurosurgeons mostly use the stereotactic atlas of Schaltenbrand with Hassler's nomenclature of the thalamus. Neuroanatomists use different nomenclatures for the primate thalamus...
  75. pmc Her6 regulates the neurogenetic gradient and neuronal identity in the thalamus
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, United Kingdom
    Proc Natl Acad Sci U S A 106:19895-900. 2009
    ..In the mammalian thalamus and other brain regions, neurogenesis is regulated also in a spatially progressive manner referred to as a ..
  76. ncbi Thalamic neurodegeneration in multiple sclerosis
    Alberto Cifelli
    Centre for Functional Magnetic Resonance Imaging of the Brain, John Radcliffe Hospital, Headley Way, Headington, Oxford OX3 9DU, UK
    Ann Neurol 52:650-3. 2002
    ..Our results show that neuronal loss in multiple sclerosis can be substantial (30-35% reduction). We conclude that a neurodegenerative pathology may make a major contribution to the genesis of symptoms in multiple sclerosis...
  77. ncbi Thalamic relay functions and their role in corticocortical communication: generalizations from the visual system
    R W Guillery
    Department of Anatomy, University of Wisconsin School of Medicine, 1300 University Avenue, Madison, WI 53706, USA
    Neuron 33:163-75. 2002
    ..Most, possibly all, afferents reaching thalamus, ascending and cortical, are branches of axons that innervate lower (motor) centers, so that thalamocortical ..
  78. pmc Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain
    J Gotman
    Montreal Neurological Institute and Department of Neurology and Neurosurgery, McGill University, 3801 University Street, Montreal, QC, Canada H3A 2B4
    Proc Natl Acad Sci U S A 102:15236-40. 2005
    ..Activations were found bilaterally and symmetrically in the thalamus, mesial midfrontal region, insulae, and midline and bilateral cerebellum and on the borders of the lateral ..
  79. ncbi Spectrotemporal receptive fields in the lemniscal auditory thalamus and cortex
    Lee M Miller
    W M Keck Center for Integrative Neuroscience, University of California Medical Center, San Francisco, CA 94143, USA
    J Neurophysiol 87:516-27. 2002
    Receptive fields have been characterized independently in the lemniscal auditory thalamus and cortex, usually with spectrotemporally simple sounds tailored to a specific task...
  80. pmc Pathway-specific feedforward circuits between thalamus and neocortex revealed by selective optical stimulation of axons
    Scott J Cruikshank
    Department of Neuroscience, Brown University, Providence, RI 02912, USA
    Neuron 65:230-45. 2010
    Thalamocortical and corticothalamic pathways mediate bidirectional communication between the thalamus and neocortex. These pathways are entwined, making their study challenging...
  81. ncbi The development of the thalamic motor learning area is regulated by Fgf8 expression
    Almudena Martinez-Ferre
    Instituto de Neurociencias, Universidad Miguel Hernandez Consejo Superior de Investigaciones Cientificas, 03550 San Juan de Alicante, Spain
    J Neurosci 29:13389-400. 2009
    ..This region specializes to permit the development of adaptive control of the motor function in the vertebrate brain...
  82. ncbi Influence of the thalamus on spatial visual processing in frontal cortex
    Marc A Sommer
    Department of Neuroscience, The Center for the Neural Basis of Cognition, and the Center for Neuroscience at the University of Pittsburgh, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Nature 444:374-7. 2006
    ..Here we show that such a link is formed by a corollary discharge from the thalamus that targets the frontal cortex...
  83. ncbi Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants
    Cheng Ji Zhou
    Department of Neurology, Program in Neuroscience, University of California, San Francisco 94143 0435, USA
    J Neurosci 24:7632-9. 2004
    ..low-density lipoprotein receptor-related protein-6 (LRP6) have a smaller and severely disorganized dorsal thalamus and lack thalamocortical projections...
  84. ncbi Cortical and thalamic axon pathfinding defects in Tbr1, Gbx2, and Pax6 mutant mice: evidence that cortical and thalamic axons interact and guide each other
    Robert F Hevner
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, California 94143 0984, USA
    J Comp Neurol 447:8-17. 2002
    ..Pioneer axons from the cortex and thalamus first meet in the intermediate zone of the subcortical telencephalon (subpallium)...
  85. ncbi Thalamic synchrony and dynamic regulation of global forebrain oscillations
    John R Huguenard
    Department of Neurology and Neurological Sciences, Room M016 Medical Center, Stanford University School of Medicine, Stanford, CA 94305, USA
    Trends Neurosci 30:350-6. 2007
    The circuitry within the thalamus creates an intrinsic oscillatory unit whose function depends critically on reciprocal synaptic connectivity between excitatory thalamocortical relay neurons and inhibitory thalamic reticular neurons along ..
  86. ncbi Thalamic atrophy and cognition in multiple sclerosis
    M K Houtchens
    Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners MS Center, Boston, MA 02115, USA
    Neurology 69:1213-23. 2007
    ..with cognitive impairment, suggesting clinical relevance of damage to surrounding structures, such as the thalamus. Previous imaging and pathology studies have demonstrated thalamic involvement in MS...
  87. ncbi Functional anatomy of thalamus and basal ganglia
    Maria Trinidad Herrero
    Experimental Neurology and Neurosurgery Group, Department of Morphological Sciences and Psychobiology, School of Medicine, University of Murcia, Campus Espinardo, 30071 Murcia, Spain
    Childs Nerv Syst 18:386-404. 2002
    b>THALAMUS: The human thalamus is a nuclear complex located in the diencephalon and comprising of four parts (the hypothalamus, the epythalamus, the ventral thalamus, and the dorsal thalamus)...
  88. ncbi Effect of subthreshold up and down states on the whisker-evoked response in somatosensory cortex
    Robert N S Sachdev
    Department of Biology, University of Texas, San Antonio 78249 0662, USA
    J Neurophysiol 92:3511-21. 2004
    ..Direct electrical stimulation of the thalamus showed the same dependence on the cell's state at the time of the stimulus, ruling out a strictly thalamic ..
  89. ncbi Chronic anterior thalamus stimulation for intractable epilepsy
    Mojgan Hodaie
    Division of Neurosurgery, University of Toronto, ON, Canada
    Epilepsia 43:603-8. 2002
    ..We investigated neuromodulation of the anterior thalamus by using deep-brain stimulation (DBS) in patients with intractable seizures.
  90. ncbi Evolving concepts on the pathophysiology of absence seizures: the cortical focus theory
    Hanneke Meeren
    F C Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, Nijmegen, The Netherlands
    Arch Neurol 62:371-6. 2005
    ..suggested that discharges originate from a deep-seated diffusely projecting subcortical pacemaker in the midline thalamus. This concept was refined in 1991 with the "thalamic clock" theory, implying that the reticular ..
  91. ncbi Combinatorial expression patterns of LIM-homeodomain and other regulatory genes parcellate developing thalamus
    Y Nakagawa
    Molecular Neurobiology Laboratory, The Salk Institute, La Jolla, California 92037, USA
    J Neurosci 21:2711-25. 2001
    The anatomical and functional organization of dorsal thalamus (dTh) and ventral thalamus (vTh), two major regions of the diencephalon, is characterized by their parcellation into distinct cell groups, or nuclei, that can be histologically ..
  92. pmc Neocortex network activation and deactivation states controlled by the thalamus
    Akio Hirata
    Department of Neurobiology and Anatomy, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA
    J Neurophysiol 103:1147-57. 2010
    ..firing level of thalamocortical cells, produced by cholinergic and noradrenergic stimulation of the somatosensory thalamus in urethane-anesthetized rats, controls neocortex activation and deactivation...
  93. ncbi Cellular mechanisms of the slow (<1 Hz) oscillation in thalamocortical neurons in vitro
    Stuart W Hughes
    School of Biosciences, Cardiff University, Museum Avenue, CF10 3US, Cardiff, United Kingdom
    Neuron 33:947-58. 2002
    ..These results suggest an active role for the thalamus in shaping the slow (<1 Hz) sleep rhythm.
  94. ncbi Otx1l, Otx2 and Irx1b establish and position the ZLI in the diencephalon
    Steffen Scholpp
    MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Campus, King s College London, London SE1 1UL, UK
    Development 134:3167-76. 2007
    ..sensory relay station in the vertebrate brain and comprises three developmental subregions: the prethalamus, the thalamus and an intervening boundary region - the zona limitans intrathalamica (ZLI)...
  95. ncbi A basal ganglia pacemaker formed by the subthalamic nucleus and external globus pallidus
    D Plenz
    Department of Anatomy and Neurobiology, University of Tennessee, College of Medicine, Memphis 38163, USA
    Nature 400:677-82. 1999
    ..We propose that the STN and GPe constitute a central pacemaker modulated by striatal inhibition of GPe neurons. This pacemaker could be responsible for synchronized oscillatory activity in the normal and pathological basal ganglia...
  96. ncbi Diverse types of interneurons generate thalamus-evoked feedforward inhibition in the mouse barrel cortex
    J T Porter
    Department of Neurobiology and Anatomy and the Sensory Neuroscience Research Center, West Virginia University, Morgantown, West Virginia 26506-9128, USA
    J Neurosci 21:2699-710. 2001
    Sensory information, relayed through the thalamus, arrives in the neocortex as excitatory input, but rapidly induces strong disynaptic inhibition that constrains the cortical flow of excitation both spatially and temporally...
  97. ncbi Partially enhanced thalamocortical functional connectivity in autism
    Akiko Mizuno
    Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, CA 92120, USA
    Brain Res 1104:160-74. 2006
    ..We examined the functional connectivity between thalamus and cerebral cortex in terms of blood oxygen level dependent (BOLD) signal cross-correlation in 8 male ..
  98. ncbi Morphological abnormalities of the thalamus in youths with attention deficit hyperactivity disorder
    Iliyan Ivanov
    ivision of Child and Adolescent Psychiatry, Mount Sinai School of Medicine, New York 10029, USA
    Am J Psychiatry 167:397-408. 2010
    The role of the thalamus in the genesis of attention deficit hyperactivity disorder (ADHD) remains poorly understood...
  99. ncbi Barrel cortex microcircuits: thalamocortical feedforward inhibition in spiny stellate cells is mediated by a small number of fast-spiking interneurons
    Qian Quan Sun
    Department of Neurology and Neurological Sciences, Stanford School of Medicine, Stanford, California 94305, USA
    J Neurosci 26:1219-30. 2006
    ..The ready activation of FS cells by TC inputs, coupled with powerful feedforward inhibition from these neurons, would profoundly influence sensory processing and constrain runaway excitation in vivo...
  100. ncbi Dynamic spatiotemporal gene expression in embryonic mouse thalamus
    Asuka Suzuki-Hirano
    RIKEN Brain Science Institute, Saitama, Japan
    J Comp Neurol 519:528-43. 2011
    The anatomy of the mammalian thalamus is characterized by nuclei, which can be readily identified in postnatal animals...
  101. ncbi Volumetric analysis and three-dimensional glucose metabolic mapping of the striatum and thalamus in patients with autism spectrum disorders
    M Mehmet Haznedar
    Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1505, New York, NY 10029, USA
    Am J Psychiatry 163:1252-63. 2006
    ..The authors used imaging studies to map volumetric and metabolic differences within the entire dorsoventral extent of the striatum and thalamus.

Research Grants73

  1. Persisting Grand Mal and Myoclonic Seizures in JME including Veterans
    Antonio V Delgado-Escueta; Fiscal Year: 2013
    ..and pedunculopontine pathway system, and compare neuropathology of caudate, putamen, globus pallidus, thalamus substantia nigra and brainstem especially superior coliculus and dorsal pons varolii of Myoclonin1/efhc1 KO mice ..
  2. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..g., thalamus, brainstem, and cerebellum)...
  3. Modulation of subcortical visual information processing
    CHARLES LEROY COX; Fiscal Year: 2012
    ..The thalamus receives rich peptidergic innervation from brainstem, neocortical and thalamic neurons...
  4. Genetic and Optogenetic Models to Dissect the Role of the Serotonin 1B Receptor
    Katherine M Nautiyal; Fiscal Year: 2013
    ..axon terminals of serotonergic and non-serotonergic neurons localized broadly in the basal ganglia, hippocampus, thalamus, cerebellum and raphe...
  5. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly H Koller; Fiscal Year: 2010
    ..These neurons project too many regions of the brain including the cortex, thalamus, hypothalamus, and amygdala...
  6. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..PROJECT 1 Principal Investigator: Dieter Jaeger, PhD Title: The Role of Mouse Motor Thalamus Relaying Basal Ganglia Outflow Description (provided by applicant): We will examine how the motor thalamus in ..
  7. Behavior Therapy for Adults with Tourette Syndrome
    Lawrence Scahill; Fiscal Year: 2009
    ..A substantial body of evidence implicates dysfunction of cortical-subcortical pathways involving the thalamus, basal ganglia and the frontal cortex...
  8. Scheduled and Responsive Brain Stimulation for the Treatment of Tourette Syndrome
    Michael S Okun; Fiscal Year: 2010
    ..TS can also include a wide spectrum of behavioral symptoms. One brain area, the centromedian thalamus (CM) has shown the most promise (N>20) as a therapeutic target for DBS in refractory TS...
  9. Modulation of subcortical visual information processing
    Charles Cox; Fiscal Year: 2009
    ..The thalamus receives rich peptidergic innervation from brainstem, neocortical and thalamic neurons...
  10. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..in eight brain areas, including striatum, subthalamic nucleus, globus pallidus, motor and sensory cortices, thalamus, and substantia nigra pars compacta...
  11. Structural consequences of TSC gene mutations in brain
    Peter B Crino; Fiscal Year: 2012
    ..will define subtle structural alterations distinct from tubers in post-mortem TSC brain specimens in the cortex, thalamus, basal ganglia, and cerebellum which may contribute to neurocognitive abnormalites in TSC using neuronal and ..
  12. GABA channels and dopamine in striatum
    Stefano Vicini; Fiscal Year: 2013
    ..in the striatum, the medium spiny neuron (MSN), receives converging glutamatergic innervation from the cortex and thalamus and dopaminergic innervation from the substantia nigra...
  13. CGRP-induced light aversion in a preclinical migraine model
    Andrew F Russo; Fiscal Year: 2013
    ..We hypothesize that CGRP can act in the thalamus to trigger light aversion following stress-induced neurogenic inflammation...
  14. Mechanisms of Alcohol Withdrawal
    Dwayne W Godwin; Fiscal Year: 2012
    ..Underlying withdrawal seizure is an abnormal brain rhythm that is produced in the thalamus by neurons firing rhythmic bursts of action potentials...
  15. CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop
    Michelle M McCarthy; Fiscal Year: 2013
    ..a network disorder, involving alteration of the dynamics within and between the nuclei of the basal ganglia, the thalamus and the cortex...
  16. Role of inflammation in manganese neurotoxicity: molecular mechanisms
    Nikolay M Filipov; Fiscal Year: 2010
    ..The project has the following Specific Aims: 1) determine, in a time-, brain region (striatum, globus pallidus, thalamus, substantia nigra)-, concentration-, and route of exposure- dependent fashion, the molecular alterations caused ..
  17. Neuromorphometry of Psychosis in Bipolar Disorder
    Daniel Mamah; Fiscal Year: 2013
    ..1) collect MRI scans from 40 PBD and 40 NPBD subjects and generate volume and shape metrics for the hippocampus, thalamus and basal ganglia, and measures of corpus callosum integrity, 2) compare these measures between PBD, NPBD, SCZ ..
  18. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2013
    ..Specific Aim 2 will determine the requirement for Islet1 in the correct formation of the reticular thalamus and zona incerta as well as their subsequent role in the correct formation of the striatal output pathways...
  19. Ethanol modulation of nicotinic receptors
    John McDaid; Fiscal Year: 2013
    ..Brainstem tegmental projections to limbic areas, basal ganglia and the thalamus contribute to many behaviors including reward, arousal, motor control and sensitization to drugs of abuse...
  20. Neuronal Mechanisms for Fear Memory Generalization in PTSD and Anxiety Disorders
    Wei Xu; Fiscal Year: 2013
    ..Moreover, I discovered that nucleus reuniens of the midline thalamus which anatomically connects the prefrontal cortex to the hippocampus also plays an essential role...
  21. The Role Leptin on Arousal
    PAIGE B BECK; Fiscal Year: 2013
    ..system (RAS) is the pedunculopontine nucleus (PPN), which is the cholinergic arm of the RAS, and projects to the thalamus to trigger thalamocortical rhythms, and to the brainstem to modulate muscle tone and locomotion...
  22. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2013
    ..organization of vestibular and (interoceptive) nociceptive pathways through the parabrachial nucleus and thalamus. Specific Aim 1 tests the hypothesis that the vestibular ganglion cells have marker phenotypes that parallel ..
  23. Mapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric Imaging
    Valerian E Kagan; Fiscal Year: 2013
    ..Studies in experimental TBI have revealed that the cortex, hippocampus and thalamus are selectively vulnerable to injury...
  24. Quantitative MR Imaging &Proton Spectroscopy in MS.
    Yulin Ge; Fiscal Year: 2013
    ..experienced by MS patients are consequences of oxidative injury by iron accretion in the basal ganglia and thalamus. To test this hypothesis, we propose four Specific Aims: Specific Aim 1 defines baseline perfusion (cerebral ..
  25. Epilepsy Training Grant
    John R Huguenard; Fiscal Year: 2013
    ..and hippocampal epileptogenesis;effects of drugs and transmitters on neurons and network activity in cortex and thalamus;development, organization, and synaptic physiology of the CNS, especially neocortex and hippocampus;cellular and ..
  26. ORGANIZATION OF PREFRONTAL FEEDBACK CIRCUITS
    Helen Barbas; Fiscal Year: 2013
    ..the mediodorsal thalamic nucleus on the inhibitory thalamic reticular nucleus, which gates signals between the thalamus and cortex, and may allow emotionally salient stimuli to gain rapid access to the cortex...
  27. Mapping the Inputs onto Neocortical Chandelier Cells
    Jason M Tucciarone; Fiscal Year: 2013
    ..Mapping (CRACM) will be used to map the long range presynaptic cells in areas such the contralateral cortex, thalamus and neurmodulatory nuclei...
  28. Novel actions of neurosteroids on GABA (A) receptor trafficking
    Stephen J Moss; Fiscal Year: 2013
    ..and ? subunits, which mediate the majority of tonic inhibition in the dentate gyrus and thalamus. Neurosteroids specifically potentiate PKC-dependent phosphorylation of serine 443 (S443) in the [unreadable]4 ..
  29. Chronic nicotine: cell-specific receptor and circuit alterations in basal ganglia
    Henry A Lester; Fiscal Year: 2013
    ..If CSAUR occurs in STN, burst firing will be studied. Medium spiny neurons (MSNs) in dorsal thalamus will be studied to determine whether chronic nicotine changes alpha4* function at the DA terminals...
  30. CENTRAL THALAMIC DEEP BRAIN STIMULATION MODELS
    Nicholas D Schiff; Fiscal Year: 2013
    ..studies is to develop two complementary animal models to advance deep brain stimulation (DBS) of the central thalamus (CT) as a therapeutic strategy for the treatment of acquired cognitive disabilities resulting from traumatic ..
  31. Structure &Function of Ganglion-Cell Photoreceptors Contributing to Form Vision
    MAUREEN ESTRELLITA ESTEVEZ; Fiscal Year: 2013
    ..ipRGCs projecting to two image-forming visual centers of the brain - the dorsal lateral geniculate nucleus of the thalamus (dLGN) and the superior colliculus (SC)...
  32. Basal Ganglia-Thalamic Interactions in Behaving Songbirds During Learning
    JESSE HEYMANN GOLDBERG; Fiscal Year: 2011
    ..2010), I am now poised to ask basic questions of BG function: How are BG outputs processed in the thalamus? How do distinct BG cell classes implement motor learning? What are the neural interactions within the BG circuit?..
  33. Basal Ganglia-Thalamic Interactions in Behaving Songbirds During Learning
    JESSE HEYMANN GOLDBERG; Fiscal Year: 2013
    ..2010), I am now poised to ask basic questions of BG function: How are BG outputs processed in the thalamus? How do distinct BG cell classes implement motor learning? What are the neural interactions within the BG circuit?..
  34. Trigeminal Nerve Stimulation for Epilepsy
    Christopher DeGiorgio; Fiscal Year: 2012
    ..connections with brain structures known to play a role in seizure inhibition and initiation (locus coeruleus, thalamus, and cerebral cortex)...
  35. The Treatment of Depression with Yoga and Walking
    CHRIS CONWAY STREETER; Fiscal Year: 2013
    ..and compare baseline GABA levels in MDD and non-depressed healthy subjects (ND) in three anatomic structures, the thalamus, insula and hippocampal/amygdala complex...
  36. Migraine pathophysiology: neural basis of photophobia
    Rami Burstein; Fiscal Year: 2013
    ..trigeminal pain fibers in cranial dura mater, and central nociceptive neurons in the medullary dorsal horn, thalamus, and cortex...
  37. FUNCTIONAL ORGANIZATION OF PRIMARY AUDITORY CORTEX
    Christoph E Schreiner; Fiscal Year: 2013
    ..assess the parameter distributions of the multiple-feature receptive fields and their nonlinearities in auditory thalamus and auditory cortical core areas...
  38. Organization and Function of Striatal Microcircuits in Health and Disease
    ARYN HILARY GITTIS; Fiscal Year: 2013
    ..Long- standing theories about inputs to FS interneurons from the cortex and thalamus have shaped thinking about the organization of striatal microcircuits, but these dogmatic theories are based ..
  39. Organization and Function of Striatal Microcircuits in Health and Disease
    ARYN HILARY GITTIS; Fiscal Year: 2012
    ..Long- standing theories about inputs to FS interneurons from the cortex and thalamus have shaped thinking about the organization of striatal microcircuits, but these dogmatic theories are based ..
  40. Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response.
    Fatta B Nahab; Fiscal Year: 2013
    ..g. b-blockers, anticonvulsants, benzodiazepines) and rarely deep brain stimulation of the Vim thalamus. Despite the assortment of agents used to treat ET, only ~50% of patients benefit from a particular agent...
  41. Prefrontal-Amygdala Interactions in Fear Conditioning
    Gregory J Quirk; Fiscal Year: 2012
    ..evaluate the contribution of candidate inputs to IL (from the hippocampus, basolateral amygdala, or mediodorsal thalamus) in the consolidation of fear extinction, using post-training pharmacological inactivation...
  42. In vivo magnetic resonance-based analysis of inherited neurologic disease after g
    HEATHER G EDWARDS; Fiscal Year: 2013
    ..with the 7T scanner and quantitative measurements will be taken of cortical and subcortical targets such as the thalamus, caudate nucleus and brain stem...
  43. Thalamic Visual Prosthesis
    John S Pezaris; Fiscal Year: 2013
    ..This device has microelectrodes placed in the lateral geniculate nucleus of the thalamus, part of the brain that relays signals from the eye to the rest of the visual system...
  44. Investigating corticostriatal pathways relevant to cocaine addiction with DREADDs
    KERRY ANN KERSTETTER; Fiscal Year: 2013
    ..The PFC sends a major glutamatergic input to the NAC, however the NAC also receives input from the amygdala and thalamus and it is unknown if the input from the PFC to the NAC is the critical pathway for regulating addiction processes...
  45. MR Imaging of the Excitatory and Inhibitory Neurotransmitters in Chronic Pain
    Bradley Foerster; Fiscal Year: 2013
    ..implicated in pain processing including the anterior insula, posterior insula, anterior cingulate cortex, and thalamus. The following specific aims are proposed: 1...
  46. Decision Support System for Temporal Lobe Epilepsy
    Hamid Soltanian-Zadeh; Fiscal Year: 2013
    ..analysis and feature extraction methods will segment and characterize hippocampus, amygdala, entorhinal cortex, thalamus, putamen, and other brain structures from MRI...
  47. Basal ganglia-thalamic signaling in parkinsonism and deep brain stimulation
    ROBERT STERLING TURNER; Fiscal Year: 2013
    ..The experiments in this proposal focus on the idea that communication between GPi and BG-recipient thalamus is a central factor in the pathophysiology of Parkinsonism and its amelioration during DBS...
  48. Parafascicular Nucleus: Its Role in Cortical and Striatal Salience Encoding
    Catherine A Thorn; Fiscal Year: 2013
    ..The centre median and parafascicular nuclei (CM/Pf) of the thalamus are hypothesized to play a critical role in the sensorimotor process of attentional orienting...
  49. The Role of the Thalamus in Taste Processing
    Kenichi Tokita; Fiscal Year: 2011
    ..According to current models, the parvicellular division of the ventroposteromedial nucleus of the thalamus (VPMpc) serves as an obligatory taste relay nucleus between the pontine parabrachial nucleus and the gustatory ..
  50. Epilepsy and dendritic excitability
    Nicholas P Poolos; Fiscal Year: 2013
    ..in several brain regions involved in the pathogenesis of epilepsy, including hippocampus, neocortex, and thalamus. The preponderance of evidence shows that downregulation of Ih, the current generated by HCN channels, is ..
  51. Effects of Cochlear Lesions on Thalamocortical Rhythms-Relationship to Tinnitus
    Daniel Stolzberg; Fiscal Year: 2012
    ..In the brain, the thalamus and cortex are intimately wired together into a reciprocal circuit;the thalamus targets the cortex, and the ..
  52. Inhibitory Interneurons in Tourette Syndrome
    Flora M Vaccarino; Fiscal Year: 2010
    ..These are inhibitory neurons projecting to the thalamus. By contrast, PV neuron number and density were decreased in the Caudate (Cd), Putamen (Pt) and insular cerebral ..
  53. AUDITORY MEMORIES AND VOCAL LEARNING
    Frederic E Theunissen; Fiscal Year: 2013
    ..In previous work, we have characterized responses in the avian auditory midbrain, thalamus and in the primary and secondary auditory cortex...
  54. Consequences of Cardiac Arrest: Brain Injury
    NITISH VYOMESH THAKOR; Fiscal Year: 2013
    ..compelling therapeutic benefits of hypothermia following CA and a better understanding of the role of the thalamus in chronic disorders of consciousness after CA...
  55. Basal Ganglia Pathways for Stopping and Switching
    Joshua D Berke; Fiscal Year: 2013
    ..we will investigate whether STN signals are specific to stopping, and whether they are driven by the intralaminar thalamus, an area involved in fast orienting reactions...
  56. Pathophysiology of Dystonia
    Mark S Baron; Fiscal Year: 2013
    ..In the ventrolateral (VL) thalamus, which receives the principal outputs from the basal ganglia, we discovered the discharge activity to be ..
  57. AAV-mediated gene therapy for GM2-gangliodoses
    MIGUEL S ESTEVES; Fiscal Year: 2012
    ..GM2 mice will demonstrate first the bioequivalence of a new AAV vector formulation injected bilaterally into the thalamus and deep cerebellar nuclei, followed by long-term efficacy and safety studies out to 20 months of age...
  58. Promoting axonal growth and tissue repair in stem cell therapy after stroke
    Ling Wei; Fiscal Year: 2012
    ..Specific Aim 3 will be devoted to the functional assessments specific for the whisker-thalamus-barrel cortex pathway...
  59. Tonic Inhibition in Thalamocortical Network Function and Absence Epilepsy
    Mathew V Jones; Fiscal Year: 2013
    ..currents, activated by endogenous ambient GABA, are completely lost in excitatory cells of the cortex and thalamus of RQ mice, leading us to hypothesize that such loss is responsible for their absence epilepsy phenotype...
  60. Neuronal Pathways for Social Rejection: fMRI Studies
    DAVID TAI HSU; Fiscal Year: 2013
    ..that in addition to the anterior cingulate cortex, activation will be found in the periaqueductal gray, thalamus, amygdala, nucleus accumbens, and subgenual cortex...
  61. PET Imaging Agents for a4b2 Nicotinic Receptors
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..In animal PET studies selective binding of 18F-Nifene in thalamus, lateral geniculate, cortex and other brain regions was observed with limited binding in the cerebellum, ..
  62. Paraventricular thalamic nucleus: Role of orexin and opioids in ethanol intake
    JESSICA ROSE BARSON; Fiscal Year: 2013
    ..regions, recent evidence focuses attention on a relatively understudied area, the paraventricular nucleus of the thalamus (PVT), which provides an important relay point between the homeostasis-regulating hypothalamus and emotion-..
  63. HISTAMINE, IL-1 & NITRIC OXIDE IN WERNICKE LESIONS
    PHILIP LANGLAIS; Fiscal Year: 2002
    ..Regions of thalamus, mammillary, body, and certain brainstem nuclei are particularly vulnerable to TD-induced lesions...
  64. OROFACIAL PAIN PATHWAYS
    BARRY GRUNWERG; Fiscal Year: 1993
    ..a massive projection from the trigeminal brainstem complex and, in turn, project heavily upon the intralaminar thalamus, a major component of central pain systems...
  65. SYNAPTIC ORGANIZATION OF BASAL FOREBRAIN PROJECTIONS
    David Finch; Fiscal Year: 1991
    ..analyses of the synaptic organization of pathways from the rat basal forebrain to the limbic system and thalamus, and reciprocal projections from the limbic system to the basal forebrain...
  66. COMPUTERIZED IMAGE ANALYSES OF MR SCANS IN SCHIZOPHRENIA
    Martha Shenton; Fiscal Year: 2009
    ..in schizophrenia, as well as the anterior limb of the internal capsule, a fiber tract connecting medial dorsal thalamus with prefrontal cortex, and the anterior nucleus of the thalamus with the cingulate gyrus, regions also thought ..
  67. Functionally Significant Polymorphisms in Serotonin Pathway Genes
    Beverly Koller; Fiscal Year: 2009
    ..These neurons project too many regions of the brain including the cortex, thalamus, hypothalamus, and amygdala...
  68. BRAIN AND SPINAL CORD CONTRIBUTIONS TO ANESTHETIC ACTION
    JOSEPH ANTOGNINI; Fiscal Year: 2005
    ..resulted in ablation of the noxious-evoked activation of the electroencephalogram (EEG) and single-units in the thalamus and midbrain reticular formation (MRF)...
  69. THALAMOSTRIATAL MECHANISMS OF MORPHINE ACTION
    Richard Harlan; Fiscal Year: 2003
    ..Several lines of evidence implicate the medial thalamus, especially the midline-intralaminar nuclei, in the subjective effects of opiates sought by drug abusers...
  70. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    ..changes in the rate and pattern of discharge of neurons in basal ganglia-receiving areas of the thalamus. This model will then be used to couple the electrophysiological effects of HF-DBS, which can be recorded from ..
  71. CEREBELLOTHALAMIC SYSTEM--MOTOR AND COGNITIVE CIRCUITS
    Igor Ilinsky; Fiscal Year: 1999
    DESCRIPTION: Ascending cerebellar output on its way to the cortex is processed in the thalamus, mainly in the ventral lateral nucleus (VL). In the primate, the role of the thalamus appears to be essentially more than a simple relay...
  72. THE CONNECTIONAL ORGANIZATION OF THE THALAMUS
    JOHN HARTING; Fiscal Year: 2001
    ..nigrostriatal dopaminergic pathway results in increased inhibition flowing out of the basal ganglia to the motor thalamus and, in turn, the motor cortex...
  73. Feature selectivity of auditory thalamus
    Edward Bartlett; Fiscal Year: 2005
    ..auditory cortex responses have been studied extensively and are generated largely by integrating inputs from the thalamus, we will use auditory stimuli that have been used for auditory cortex studies, such as repetitive clicks, two-..