subthalamic nucleus

Summary

Summary: Lens-shaped structure on the inner aspect of the internal capsule. The subthalamic nucleus and pathways traversing this region are concerned with the integration of somatic motor function. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p52)

Top Publications

  1. ncbi Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus
    Adam R Aron
    Department of Psychology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:2424-33. 2006
  2. ncbi Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
  3. ncbi Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
    Takao Hashimoto
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1916-23. 2003
  4. ncbi Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 43:111-7. 2002
  5. pmc Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom, Department of Clinical Neurology, University of Oxford, Oxford, OX3 9DU, United Kingdom
    J Neurosci 32:10541-53. 2012
  6. pmc Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging
    Christian Lambert
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 60:83-94. 2012
  7. ncbi Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation
    Claire Ardouin
    Departement de Neurologie, CHU Grenoble, INSERM U318, Universite Joseph Fourier, Grenoble, France
    Mov Disord 21:1941-6. 2006
  8. ncbi Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease
    Alessandro Stefani
    1IRCCS Fondazione St Lucia, 2Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Brain 130:1596-607. 2007
  9. ncbi Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
    Andrea A Kuhn
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Exp Neurol 215:380-7. 2009
  10. ncbi Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey
    A Nambu
    Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 84:289-300. 2000

Detail Information

Publications316 found, 100 shown here

  1. ncbi Cortical and subcortical contributions to Stop signal response inhibition: role of the subthalamic nucleus
    Adam R Aron
    Department of Psychology, Brain Research Institute, University of California, Los Angeles, California 90095, USA
    J Neurosci 26:2424-33. 2006
    ..It has been suggested that the subthalamic nucleus (STN), which is a part of the basal ganglia, may play a role because it is well placed to suppress the "..
  2. ncbi Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease
    Paul Krack
    Department of Clinical and Biological Neurosciences, Joseph Fourier University, Grenoble, France
    N Engl J Med 349:1925-34. 2003
    Although the short-term benefits of bilateral stimulation of the subthalamic nucleus in patients with advanced Parkinson's disease have been well documented, the long-term outcomes of the procedure are unknown.
  3. ncbi Stimulation of the subthalamic nucleus changes the firing pattern of pallidal neurons
    Takao Hashimoto
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1916-23. 2003
    ..underlying improvement of parkinsonian signs by high-frequency electrical stimulation (HFS) of the subthalamic nucleus (STN), we investigated the effects of STN HFS on neuronal activity of the internal and external segment of ..
  4. ncbi Functional significance of the cortico-subthalamo-pallidal 'hyperdirect' pathway
    Atsushi Nambu
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, 2 6 Musashidai, Fuchu, Tokyo, Japan
    Neurosci Res 43:111-7. 2002
    ..Through this sequential information processing, only the selected motor program is initiated, executed and terminated at the selected timing, whereas other competing programs are canceled...
  5. pmc Movement-related changes in local and long-range synchronization in Parkinson's disease revealed by simultaneous magnetoencephalography and intracranial recordings
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, WC1N 3BG, United Kingdom, Department of Clinical Neurology, University of Oxford, Oxford, OX3 9DU, United Kingdom
    J Neurosci 32:10541-53. 2012
    ..and, if so, in what way? We acquired simultaneously magnetoencephalography and direct recordings from the subthalamic nucleus (STN) in 17 PD patients...
  6. pmc Confirmation of functional zones within the human subthalamic nucleus: patterns of connectivity and sub-parcellation using diffusion weighted imaging
    Christian Lambert
    Wellcome Trust Centre for Neuroimaging, UCL Institute of Neurology, London, UK
    Neuroimage 60:83-94. 2012
    The subthalamic nucleus (STN) is a small, glutamatergic nucleus situated in the diencephalon. A critical component of normal motor function, it has become a key target for deep brain stimulation in the treatment of Parkinson's disease...
  7. ncbi Pathological gambling in Parkinson's disease improves on chronic subthalamic nucleus stimulation
    Claire Ardouin
    Departement de Neurologie, CHU Grenoble, INSERM U318, Universite Joseph Fourier, Grenoble, France
    Mov Disord 21:1941-6. 2006
    ..active PG due to dopaminergic treatment from a total of 598 patients who have undergone surgery for subthalamic nucleus stimulation for disabling motor fluctuations...
  8. ncbi Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease
    Alessandro Stefani
    1IRCCS Fondazione St Lucia, 2Clinica Neurologica, Dipartimento di Neuroscienze, Universita di Roma Tor Vergata, Italy
    Brain 130:1596-607. 2007
    ..We report the clinical affects of deep brain stimulation (DBS) in the PPN and subthalamic nucleus (STN)...
  9. ncbi Pathological synchronisation in the subthalamic nucleus of patients with Parkinson's disease relates to both bradykinesia and rigidity
    Andrea A Kuhn
    Department of Neurology, Charite, University Medicine Berlin, Campus Virchow, Berlin, Germany
    Exp Neurol 215:380-7. 2009
    ..Studies have demonstrated a suppression of local field potential (LFP) activity in the subthalamic nucleus (STN) upon treatment with the dopamine prodrug, levodopa, with the degree of suppression of power in the 8-..
  10. ncbi Excitatory cortical inputs to pallidal neurons via the subthalamic nucleus in the monkey
    A Nambu
    Department of Neurobiology, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    J Neurophysiol 84:289-300. 2000
    ..primary somatosensory cortices on the activity of globus pallidus (GP) neurons, especially mediated by the subthalamic nucleus (STN), have been characterized...
  11. ncbi Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease
    Alim Louis Benabid
    Department of Neurosurgery and Neurology, University of Grenoble, CHU Albert Michallon, Grenoble, France
    Lancet Neurol 8:67-81. 2009
    High-frequency deep brain stimulation (DBS) of the subthalamic nucleus (STN-HFS) is the preferred surgical treatment for advanced Parkinson's disease...
  12. ncbi The subthalamic nucleus in the context of movement disorders
    Clement Hamani
    Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
    Brain 127:4-20. 2004
    The subthalamic nucleus (STN) has been regarded as an important modulator of basal ganglia output...
  13. ncbi Using STN DBS and medication reduction as a strategy to treat pathological gambling in Parkinson's disease
    Fabio Bandini
    Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via A De Toni 5, 16132 Genoa, Italy
    Parkinsonism Relat Disord 13:369-71. 2007
    ..patients responded to the standard therapy for gambling behavior, but dramatically improved after bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) and early postoperative withdrawal of dopaminergic therapy...
  14. ncbi Reduction in subthalamic 8-35 Hz oscillatory activity correlates with clinical improvement in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WCIN 3BG, UK
    Eur J Neurosci 23:1956-60. 2006
    Strong synchronization of neuronal activity occurs in the 8-35 Hz band in the subthalamic nucleus (STN) of patients with Parkinson's disease (PD) and is evident as oscillatory local field potential (LFP) activity...
  15. ncbi Effective connectivity reveals important roles for both the hyperdirect (fronto-subthalamic) and the indirect (fronto-striatal-pallidal) fronto-basal ganglia pathways during response inhibition
    Sara Jahfari
    Department of Psychology, University of Amsterdam, 1018 WB Amsterdam, The Netherlands
    J Neurosci 31:6891-9. 2011
    ..connecting the right inferior frontal gyrus (rIFG) and the presupplementary motor area (preSMA) with the subthalamic nucleus or, alternatively, via the indirect pathway between the cortex and caudate...
  16. pmc Cognition and mood in Parkinson's disease in subthalamic nucleus versus globus pallidus interna deep brain stimulation: the COMPARE trial
    Michael S Okun
    Movement Disorders Center, University of Florida, McKnight Brain Institute, College of Medicine, Department of Neurology, Gainesville, FL 32611, USA
    Ann Neurol 65:586-95. 2009
    Our aim was to compare in a prospective blinded study the cognitive and mood effects of subthalamic nucleus (STN) vs. globus pallidus interna (GPi) deep brain stimulation (DBS) in Parkinson disease.
  17. ncbi Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up
    M C Rodriguez-Oroz
    Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra and CIMA, Pamplona, Spain
    Brain 128:2240-9. 2005
    ..We report 69 Parkinson's disease patients treated with bilateral DBS of the subthalamic nucleus (STN, n = 49) or globus pallidus internus (GPi, n = 20) included in a multicentre study...
  18. pmc Stimulation of the subthalamic nucleus and impulsivity: release your horses
    Benedicte Ballanger
    Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann Neurol 66:817-24. 2009
    In Parkinson disease (PD) patients, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may contribute to certain impulsive behavior during high-conflict decisions...
  19. pmc Deep brain stimulation of the subthalamic nucleus alters the cortical profile of response inhibition in the beta frequency band: a scalp EEG study in Parkinson's disease
    Nicole Swann
    Department of Psychology, Neuroscience Graduate Program, Institute for Neural Computation, University of California San Diego, La Jolla, California 92093, USA
    J Neurosci 31:5721-9. 2011
    ..implemented by a fronto-basal-ganglia circuit, including the right inferior frontal cortex (rIFC) and the subthalamic nucleus (STN)...
  20. pmc What brain signals are suitable for feedback control of deep brain stimulation in Parkinson's disease?
    Simon Little
    Nuffield Departments of Clinical Neurosciences, University of Oxford, United Kingdom
    Ann N Y Acad Sci 1265:9-24. 2012
    ..Finally, whether brain signals are causally important needs to be established before stimulation can be specifically patterned rather than delivered at empirically defined high frequency...
  21. ncbi How do parkinsonian signs return after discontinuation of subthalamic DBS?
    P Temperli
    Department of Neurology, Centre Hospitalier Universitaire Vaudois, Lausanne CHUV, Switzerland
    Neurology 60:78-81. 2003
    To study the reappearance of the clinical signs of PD when subthalamic nucleus (STN) deep brain stimulation (DBS) was turned off.
  22. ncbi Resting oscillatory cortico-subthalamic connectivity in patients with Parkinson's disease
    Vladimir Litvak
    Sobell Department of Motor Neuroscience, UCL Institute of Neurology, London, UK
    Brain 134:359-74. 2011
    ..A temporoparietal-brainstem network was coherent with the subthalamic nucleus in the alpha (7-13 Hz) band, whilst a predominantly frontal network was coherent in the beta (15-35 Hz) ..
  23. pmc Improvement of memory guided saccades in parkinsonian patients by high frequency subthalamic nucleus stimulation
    S Rivaud-Pechoux
    INSERM U289, Hopital de la Salpetriere, 47 bd de l Hopital, 75651 Paris Cedex 13, France
    J Neurol Neurosurg Psychiatry 68:381-4. 2000
    Recent studies in the monkey suggest that the subthalamic nucleus (STN) is involved in control of eye movement, yet its functional significance in humans is unknown...
  24. ncbi Subthalamic nucleus versus globus pallidus bilateral deep brain stimulation for advanced Parkinson's disease (NSTAPS study): a randomised controlled trial
    Vincent J J Odekerken
    Department of Neurology, Academic Medical Center, Amsterdam, Netherlands
    Lancet Neurol 12:37-44. 2013
    ..We assessed whether globus pallidus pars interna (GPi) deep brain stimulation (DBS) gives greater functional improvement than does subthalamic nucleus (STN) DBS.
  25. ncbi Effects of subthalamic nucleus stimulation on actual and imagined movement in Parkinson's disease : a PET study
    Stephane Thobois
    Service de Neurologie D, Hopital Neurologique Pierre Wertheimer, Lyon
    J Neurol 249:1689-98. 2002
    PET studies in moderately affected Parkinson's disease (PD) patients reveal abnormal cerebral activation during motor execution and imagery, but the effects of subthalamic nucleus (STN) stimulation are not well established.
  26. pmc Subthalamic nucleus stimulation modulates thalamic neuronal activity
    Weidong Xu
    Department of Neurosciences, Lerner Research Institute of the Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Neurosci 28:11916-24. 2008
    Deep brain stimulation (DBS) in the subthalamic nucleus (STN) is an effective tool for the treatment of advanced Parkinson's disease. The mechanism by which STN DBS elicits its beneficial effect, however, remains unclear...
  27. ncbi Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthria
    Michèle Gentil
    INSERM, Unit 318, CHU, Service neurologie, BP 217 38043, Grenoble Cedex 9, France
    Brain Lang 85:190-6. 2003
    Never was the effect of bilateral stimulation of the subthalamic nucleus (STN) evaluated quantitatively on all the components of speech production, that is articulation, respiration and phonation, at the same time...
  28. ncbi Effects of bilateral subthalamic nucleus stimulation and medication on parkinsonian speech impairment
    Lucia D'Alatri
    Institute of Otorhinolaryngology, Universita Cattolica S Cuore, Rome, Italy
    J Voice 22:365-72. 2008
    This study aimed to assess quantitatively the effect of bilateral subthalamic nucleus (STN) stimulation and medication on hypokinetic parkinsonian dysarthria...
  29. ncbi Resting state fMRI reveals increased subthalamic nucleus-motor cortex connectivity in Parkinson's disease
    Simon Baudrexel
    Department of Neurology, University Hospital, Goethe University Frankfurt am Main, Frankfurt am Main, Germany
    Neuroimage 55:1728-38. 2011
    ..The clinical effectiveness of subthalamic nucleus (STN) high frequency stimulation indicates a crucial role of this nucleus within the affected motor ..
  30. ncbi The cerebral oscillatory network of parkinsonian resting tremor
    Lars Timmermann
    Department of Neurology, Heinrich Heine University, Duesseldorf, Germany
    Brain 126:199-212. 2003
    ..The main frequency of cerebro-cerebral coupling corresponds to double the tremor frequency...
  31. ncbi Neuropsychological and psychiatric changes after deep brain stimulation for Parkinson's disease: a randomised, multicentre study
    Karsten Witt
    Christian Albrechts University, Kiel, Germany
    Lancet Neurol 7:605-14. 2008
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) reduces motor symptoms in patients with Parkinson's disease (PD) and improves their quality of life; however, the effect of DBS on cognitive functions and its psychiatric side-..
  32. ncbi Dopamine dependency of oscillations between subthalamic nucleus and pallidum in Parkinson's disease
    P Brown
    Medical Research Council Human Movement and Balance Unit, Institute of Neurology, London WCIN 3BG, United Kingdom
    J Neurosci 21:1033-8. 2001
    ..We simultaneously recorded local potentials (LPs) from the globus pallidus interna (GPi) and subthalamic nucleus (STN) in four awake patients after neurosurgery for Parkinson's disease...
  33. ncbi The functional role of the subthalamic nucleus in cognitive and limbic circuits
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, University of Maastricht, The Netherlands
    Prog Neurobiol 76:393-413. 2005
    Once it was believed that the subthalamic nucleus (STN) was no more than a relay station serving as a "gate" for ascending basal ganglia-thalamocortical circuits...
  34. ncbi Stimulation of the caudal zona incerta is superior to stimulation of the subthalamic nucleus in improving contralateral parkinsonism
    Puneet Plaha
    Institute of Neurosciences, Department of Neurosurgery, Frenchay Hospital Bristol, UK
    Brain 129:1732-47. 2006
    ..Although, the subthalamic nucleus (STN) is the commonly chosen target, a number of groups have reported that the most effective contact lies ..
  35. ncbi Dopamine regulates the impact of the cerebral cortex on the subthalamic nucleus-globus pallidus network
    P J Magill
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK
    Neuroscience 106:313-30. 2001
    The subthalamic nucleus-globus pallidus network plays a central role in basal ganglia function and dysfunction...
  36. pmc Greater improvement in quality of life following unilateral deep brain stimulation surgery in the globus pallidus as compared to the subthalamic nucleus
    Laura B Zahodne
    Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610 0165, USA
    J Neurol 256:1321-9. 2009
    ..The study reported here directly compared the effects of unilateral DBS in subthalamic nucleus (STN) or globus pallidus (GPi) on QoL in 42 non-demented patients with medication-refractory PD...
  37. ncbi Effects of STN stimulation on the initiation and inhibition of saccade in Parkinson disease
    A Yugeta
    Department of Neurology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Neurology 74:743-8. 2010
    The basal ganglia (BG) play an important role in controlling saccades. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is widely used as a treatment of Parkinson disease (PD) by altering the function of the BG...
  38. pmc Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation
    R Hilker
    Department of Neurology, University Hospital, Joseph Stelzmann Strasse 9, 50924 Cologne, Germany
    J Neurol Neurosurg Psychiatry 76:1217-21. 2005
    Glutamate mediated excitotoxicity of the hyperactive subthalamic nucleus (STN) has been reported to contribute to nigral degeneration in Parkinson's disease (PD)...
  39. ncbi Subthalamic nucleus deep brain stimulation: summary and meta-analysis of outcomes
    Galit Kleiner-Fisman
    Parkinson s Disease Research Education and Clinical Center, Philadelphia VA Hospital, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 21:S290-304. 2006
    b>Subthalamic nucleus (STN) deep brain stimulation (DBS) is currently the most common therapeutic surgical procedure for patients with Parkinson's disease (PD) who have failed medical management...
  40. ncbi Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease
    Kenneth A Follett
    Iowa City Veterans Affairs Medical Center, Iowa City, USA
    N Engl J Med 362:2077-91. 2010
    ..The globus pallidus interna and the subthalamic nucleus are accepted targets for this procedure...
  41. ncbi High frequency stimulation of the subthalamic nucleus impacts adult neurogenesis in a rat model of Parkinson's disease
    Vitaly Khaindrava
    IC2N, IBDML, UMR6216 CNRS Université de la Méditerranée, Marseille, France
    Neurobiol Dis 42:284-91. 2011
    Chronic high frequency stimulation of the subthalamic nucleus (STN-HFS) efficiently alleviates motor symptoms of advanced Parkinson's disease (PD)...
  42. pmc Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat
    Ruth H Walker
    Department of Neurology, James J Peters Veterans Affairs Medical Center, Bronx, New York, United States of America
    PLoS ONE 7:e32919. 2012
    ..disease and may respond to neurosurgical interventions, specifically stimulation or lesioning of the subthalamic nucleus (STN)...
  43. ncbi Determining the position and size of the subthalamic nucleus based on magnetic resonance imaging results in patients with advanced Parkinson disease
    Erich O Richter
    Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
    J Neurosurg 100:541-6. 2004
    The subthalamic nucleus (STN) is a target in surgery for Parkinson disease, but its location according to brain atlases compared with its position on an individual patient's magnetic resonance (MR) images is incompletely understood...
  44. pmc A multicentre study on suicide outcomes following subthalamic stimulation for Parkinson's disease
    Valerie Voon
    National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD 20892 1428, USA
    Brain 131:2720-8. 2008
    b>Subthalamic nucleus deep brain stimulation improves motor symptoms and quality of life in advanced Parkinson's disease...
  45. ncbi The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation
    Helen Bronte-Stewart
    Department of Neurology and Neurological Sciences, Stanford University, CA 94305 5327, USA
    Exp Neurol 215:20-8. 2009
    ..We recorded LFPs from the subthalamic nucleus (STN) deep brain stimulation (DBS) lead in the operating room in 22 cases from 16 subjects with Parkinson's ..
  46. ncbi High frequency oscillations in the subthalamic nucleus: a neurophysiological marker of the motor state in Parkinson's disease
    Tolga Esat Ozkurt
    Institute of Clinical Neuroscience and Medical Psychology, Heinrich Heine University, Dusseldorf, Germany
    Exp Neurol 229:324-31. 2011
    ..Recordings of local field potentials from subthalamic nucleus of patients undergoing deep brain stimulation have focused on oscillations occurring at frequencies below ..
  47. ncbi Hold your horses: impulsivity, deep brain stimulation, and medication in parkinsonism
    Michael J Frank
    Department of Psychology and Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA
    Science 318:1309-12. 2007
    Deep brain stimulation (DBS) of the subthalamic nucleus markedly improves the motor symptoms of Parkinson's disease, but causes cognitive side effects such as impulsivity...
  48. ncbi Normalizing motor-related brain activity: subthalamic nucleus stimulation in Parkinson disease
    S T Grafton
    Center for Cognitive Neuroscience, Dartmouth College, Hanover, NH 03755, USA
    Neurology 66:1192-9. 2006
    To test whether therapeutic unilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson disease (PD) leads to normalization in the pattern of brain activation during movement execution and control ..
  49. ncbi High frequency stimulation of the subthalamic nucleus eliminates pathological thalamic rhythmicity in a computational model
    Jonathan E Rubin
    Department of Mathematics and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, PA 15260, USA
    J Comput Neurosci 16:211-35. 2004
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) has recently been recognized as an important form of intervention for alleviating motor symptoms associated with Parkinson'..
  50. pmc Deep brain stimulation does not silence neurons in subthalamic nucleus in Parkinson's patients
    Jonathan D Carlson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon, USA
    J Neurophysiol 103:962-7. 2010
    ..broad hypotheses have been advanced to explain the clinical efficacy of deep brain stimulation (DBS) in the subthalamic nucleus (STN) for treatment of Parkinson's disease...
  51. ncbi Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imaging
    Jean A Saint-Cyr
    Department of Surgery, Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
    J Neurosurg 97:1152-66. 2002
    ..The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD)...
  52. ncbi Stimulation of the subthalamic nucleus compared with the globus pallidus internus in patients with Parkinson disease
    Antonella Peppe
    Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, Clinica Neurologica and Servizio di Neurofisiopatologia Policlinico, Universita Tor Vergata, Rome, Italy
    J Neurosurg 101:195-200. 2004
    ..the effects of deep brain stimulation (DBS) in the globus pallidus internus (GPi) with those in the subthalamic nucleus (STN) in patients with Parkinson disease (PD) in whom electrodes had been bilaterally implanted in both ..
  53. ncbi Thalamocortical relay fidelity varies across subthalamic nucleus deep brain stimulation protocols in a data-driven computational model
    Yixin Guo
    Department of Mathematics, Drexel University, Philadelphia, PA, USA
    J Neurophysiol 99:1477-92. 2008
    The therapeutic effectiveness of deep brain stimulation (DBS) of the subthalamic nucleus (STN) may arise through its effects on inhibitory basal ganglia outputs, including those from the internal segment of the globus pallidus (GPi)...
  54. ncbi Somatotopically arranged inputs from putamen and subthalamic nucleus to primary motor cortex
    Shigehiro Miyachi
    Department of System Neuroscience, Tokyo Metropolitan Institute for Neuroscience, Tokyo Metropolitan Organization for Medical Research, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 56:300-8. 2006
    ..Four days after rabies injections into these MI regions, neuronal labeling occurred in the striatum and the subthalamic nucleus (STN) through the cortico-basal ganglia loop circuits...
  55. pmc Mapping Go-No-Go performance within the subthalamic nucleus region
    Tamara Hershey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain 133:3625-34. 2010
    ..e. response inhibition). The subthalamic nucleus has been hypothesized to play a particularly critical role in this function...
  56. ncbi The effect of unilateral electrostimulation of the subthalamic nucleus on respiratory/phonatory subsystems of speech production in Parkinson's disease--a preliminary report
    Emily Wang
    Department of Communication Disorders and Sciences, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Clin Linguist Phon 17:283-9. 2003
    ..subsystems from an on-going study investigating the effect of unilateral electrostimulation of the subthalamic nucleus (STN) on different speech subsystems in people with Parkinson's disease (PD)...
  57. ncbi Changes induced by levodopa and subthalamic nucleus stimulation on parkinsonian speech
    Serge Pinto
    Neurosciences Précliniques, INSERM Unité 318, Grenoble, France
    Mov Disord 20:1507-15. 2005
    Levodopa (L-dopa) and subthalamic nucleus (STN) stimulation treatments have been associated with both improvement and exacerbation of dysarthria in Parkinson's disease (PD)...
  58. ncbi Distinct oscillatory STN-cortical loops revealed by simultaneous MEG and local field potential recordings in patients with Parkinson's disease
    J Hirschmann
    Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Dusseldorf, Dusseldorf, Germany
    Neuroimage 55:1159-68. 2011
    ..Neurons in the subthalamic nucleus (STN) generate oscillations which are coupled to rhythmic population activity both in other basal ganglia ..
  59. ncbi Coupling between beta and high-frequency activity in the human subthalamic nucleus may be a pathophysiological mechanism in Parkinson's disease
    Jon López-Azcárate
    Neuroscience Area, Centro de Investigación Médica Aplicada, Universidad de Navarra, 31008 Pamplona, Spain
    J Neurosci 30:6667-77. 2010
    ..from a group of 15 PD patients (three females) treated with bilateral deep brain stimulation of the subthalamic nucleus, using a high sampling rate (2 kHz) and filters suitable to study high-frequency activity (0.3-1000 Hz)...
  60. ncbi High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London WC1N 3BG, United Kingdom
    J Neurosci 28:6165-73. 2008
    High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear...
  61. ncbi High-frequency stimulation produces a transient blockade of voltage-gated currents in subthalamic neurons
    C Beurrier
    Laboratoire de Neurophysiologie, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5543, , 33076 Bordeaux Cedex, France
    J Neurophysiol 85:1351-6. 2001
    The effect of high-frequency stimulation (HFS) of the subthalamic nucleus (STN) was analyzed with patch-clamp techniques (whole cell configuration, current- and voltage-clamp modes) in rat STN slices in vitro...
  62. ncbi Local field potential beta activity in the subthalamic nucleus of patients with Parkinson's disease is associated with improvements in bradykinesia after dopamine and deep brain stimulation
    N J Ray
    Department of Anatomy, Physiology and Genetics, University of Oxford, Parks Road, OX1 3PT, USA
    Exp Neurol 213:108-13. 2008
    ..with dopamine replacement medication and, more recently, by stimulating basal-ganglia nuclei such as the subthalamic nucleus (STN)...
  63. ncbi Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease
    Ron Levy
    Department of Physiology, University of Toronto, Toronto, Canada
    Brain 125:1196-209. 2002
    Local field potentials and pairs of neurones in the subthalamic nucleus (STN) of patients with Parkinson's disease show high-frequency oscillations (HFOs) at 15-30 Hz...
  64. ncbi Addiction in Parkinson's disease: impact of subthalamic nucleus deep brain stimulation
    Tatiana Witjas
    Department of Neurology, University Hospital Timone, Marseille, France
    Mov Disord 20:1052-5. 2005
    ..In addition to alleviating the motor disability in both patients, subthalamic nucleus (STN) deep brain stimulation greatly reduced the behavioral disorders as well as completely abolished the ..
  65. ncbi Effect of high-frequency stimulation of the subthalamic nucleus on the neuronal activities of the substantia nigra pars reticulata and ventrolateral nucleus of the thalamus in the rat
    A Benazzouz
    Laboratoire de Neurobiologie Preclinique, INSERM U 318, CHU Pavillon B, BP 217, 38043, Grenoble, France
    Neuroscience 99:289-95. 2000
    ..were made in anaesthetized rats to investigate the mode of function of high-frequency stimulation of the subthalamic nucleus used as a therapeutic approach for Parkinson's disease...
  66. pmc Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity
    Nicolas Mallet
    Medical Research Council Anatomical Neuropharmacology Unit, University of Oxford, Oxford OX1 3TH, UK
    J Neurosci 28:14245-58. 2008
    Inappropriately synchronized beta (beta) oscillations (15-30 Hz) in the subthalamic nucleus (STN) accompany movement difficulties in idiopathic Parkinson's disease (PD)...
  67. ncbi Beta oscillatory activity in the subthalamic nucleus and its relation to dopaminergic response in Parkinson's disease
    Moran Weinberger
    Department of Physiology, Med Sci Building 3302, 1 King s College Circle, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Neurophysiol 96:3248-56. 2006
    Recent studies suggest that beta (15-30 Hz) oscillatory activity in the subthalamic nucleus (STN) is dramatically increased in Parkinson's disease (PD) and may interfere with movement execution...
  68. ncbi Hold your horses: a dynamic computational role for the subthalamic nucleus in decision making
    Michael J Frank
    Department of Psychology, Program in Neuroscience, University of Arizona, Tucson, AZ 85721, USA
    Neural Netw 19:1120-36. 2006
    ..Nevertheless, one clear limitation of that model is in its omission of the subthalamic nucleus (STN), a key BG structure that participates in both motor and cognitive processes...
  69. pmc Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold
    James F Cavanagh
    Department of Cognitive, Linguistic and Psychological Sciences, Brown University, Providence, Rhode Island, USA
    Nat Neurosci 14:1462-7. 2011
    ..Although medial prefrontal cortex (mPFC) is broadly implicated in effortful control over behavior, the subthalamic nucleus (STN) is specifically thought to contribute by acting as a brake on cortico-striatal function during ..
  70. ncbi Surgical management of Parkinson's disease
    Thomas Foltynie
    UCL Institute of Neurology, Queen Square, London, UK
    Expert Rev Neurother 10:903-14. 2010
    ..The current cornerstone of surgical treatment for PD is high-frequency deep-brain stimulation (DBS) of the subthalamic nucleus (STN) using implantable electrodes and an implantable pulse generator/battery...
  71. pmc Stimulation of subterritories of the subthalamic nucleus reveals its role in the integration of the emotional and motor aspects of behavior
    Luc Mallet
    Institut National de la Santé et de la Recherche Médicale AVENIR Group, Behavior, Emotion, and Basal Ganglia, 75013 Paris, France
    Proc Natl Acad Sci U S A 104:10661-6. 2007
    Two parkinsonian patients who experienced transient hypomanic states when the subthalamic nucleus (STN) was stimulated during postoperative adjustment of the electrical parameters for antiparkinsonian therapy agreed to have the mood ..
  72. ncbi Spontaneous and evoked activity of substantia nigra pars reticulata neurons during high-frequency stimulation of the subthalamic nucleus
    Nicolas Maurice
    Institut National de la Santé et de la Recherche Médicale U 114, Chaire de Neuropharmacologie, College de France, 75231 Paris Cedex 05, France
    J Neurosci 23:9929-36. 2003
    The subthalamic nucleus (STN), a major component of the basal ganglia, exerts an excitatory influence on the output structures of this system i.e...
  73. ncbi Modulation of beta oscillations in the subthalamic area during motor imagery in Parkinson's disease
    Andrea A Kuhn
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    Brain 129:695-706. 2006
    ..We recorded local field potential (LPF) activity from the region of the subthalamic nucleus (STN) in eight patients with Parkinson's disease off dopaminergic medication during performance of a warned ..
  74. pmc Using point process models to compare neural spiking activity in the subthalamic nucleus of Parkinson's patients and a healthy primate
    Sridevi V Sarma
    Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Biomed Eng 57:1297-305. 2010
    Placement of deep brain stimulating electrodes in the subthalamic nucleus (STN) to treat Parkinson's disease (PD) also allows the recording of single neuron spiking activity...
  75. ncbi Effect on mood of subthalamic DBS for Parkinson's disease: a consecutive series of 24 patients
    A Berney
    Department of Psychiatry, CHUV, Lausanne, Switzerland
    Neurology 59:1427-9. 2002
    ..In six patients (25%), mood state worsened significantly, and three were transiently suicidal despite clear motor improvement. Caregivers and patients should be educated about the potential impact of this neurosurgical procedure on mood...
  76. ncbi Bilateral high-frequency stimulation in the subthalamic nucleus for the treatment of Parkinson disease: correlation of therapeutic effect with anatomical electrode position
    Jurgen Voges
    Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany
    J Neurosurg 96:269-79. 2002
    ..The goal of this study was to relate the degree of clinical improvement and that of energy consumption to the anatomical position of electrode poles used for long-term stimulation...
  77. ncbi Behavioural changes after bilateral subthalamic stimulation in advanced Parkinson disease: a systematic review
    Yasin Temel
    Department of Neurosurgery, University Hospital Maastricht, P Debyelaan 25, Maastricht, The Netherlands
    Parkinsonism Relat Disord 12:265-72. 2006
    The long-lasting beneficial effects of subthalamic nucleus (STN) deep brain stimulation (DBS) on motor function have now largely been acknowledged...
  78. ncbi Pallidal vs subthalamic nucleus deep brain stimulation in Parkinson disease
    Valerie C Anderson
    Department of Neurological Surgery, Oregon Health and Science University, Portland, OR 97201, USA
    Arch Neurol 62:554-60. 2005
    Deep brain stimulation (DBS) of the globus pallidus interna (GPi) and subthalamic nucleus (STN) has been reported to relieve motor symptoms and levodopa-induced dyskinesia in patients with advanced Parkinson disease (PD)...
  79. ncbi Computational analysis of subthalamic nucleus and lenticular fasciculus activation during therapeutic deep brain stimulation
    Svjetlana Miocinovic
    Department of Biomedical Engineering, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Neurophysiol 96:1569-80. 2006
    The subthalamic nucleus (STN) is the most common target for the treatment of Parkinson's disease (PD) with deep brain stimulation (DBS). DBS of the globus pallidus internus (GPi) is also effective in the treatment of PD...
  80. ncbi Move to the rhythm: oscillations in the subthalamic nucleus-external globus pallidus network
    Mark D Bevan
    Dept of Anatomy and Neurobiology, University of Tennessee, Memphis 38163, USA
    Trends Neurosci 25:525-31. 2002
    ..have revealed that oscillatory processes at the levels of single neurons and neuronal networks in the subthalamic nucleus (STN) and external globus pallidus (GPe) are associated with the operation of the basal ganglia in health ..
  81. ncbi Unilateral pallidotomy versus bilateral subthalamic nucleus stimulation in PD--a comparison of neuropsychological effects
    Harriet M M Smeding
    Dept of Neurology, H2 222, Academic Medical Center, 22660, 1100, DD Amsterdam, The Netherlands
    J Neurol 252:176-82. 2005
    To compare the cognitive and behavioural effects of unilateral pallidotomy and bilateral subthalamic nucleus (STN) stimulation.
  82. ncbi Deep brain stimulation for the treatment of Parkinson's disease
    Jens Volkmann
    Department of Neurology, Christian Albrechts University, Kiel, Germany
    J Clin Neurophysiol 21:6-17. 2004
    ..The subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi) are targeted for the treatment of advanced ..
  83. pmc Subthalamic nucleus activity optimizes maximal effort motor responses in Parkinson's disease
    Anam Anzak
    Functional Neurosurgery Experimental Neurology Group, Department of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
    Brain 135:2766-78. 2012
    ..a striking correlation between both theta/alpha (5-12 Hz) and high-gamma/high-frequency (55-375 Hz) subthalamic nucleus activity and force measures, which explained close to 70% of interindividual variance in maximal motor ..
  84. pmc The subthalamic microlesion story in Parkinson's disease: electrode insertion-related motor improvement with relative cortico-subcortical hypoactivation in fMRI
    Robert Jech
    Dept of Neurology and Center of Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic
    PLoS ONE 7:e49056. 2012
    Electrode implantation into the subthalamic nucleus for deep brain stimulation in Parkinson's disease (PD) is associated with a temporary motor improvement occurring prior to neurostimulation...
  85. ncbi Bilateral effects of unilateral subthalamic nucleus deep brain stimulation in advanced Parkinson's disease
    Sun J Chung
    Center for Parkinsonism and Other Movement Disorders, Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea
    Eur Neurol 56:127-32. 2006
    To investigate the bilateral effects of unilateral subthalamic nucleus deep brain stimulation (STN-DBS), we prospectively studied 9 consecutive advanced Parkinson's disease (PD) patients (2 men and 7 women) who underwent unilateral STN-..
  86. ncbi Subthalamic stimulation in Parkinson's disease: restoring the balance of motivated behaviours
    Eugénie Lhommée
    CHU de Grenoble, Pavillon de neurology, Grenoble Cedex 9, France
    Brain 135:1463-77. 2012
    ....
  87. ncbi Synchronized neuronal discharge in the basal ganglia of parkinsonian patients is limited to oscillatory activity
    Ron Levy
    Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada M5S 1A8
    J Neurosci 22:2855-61. 2002
    ..performed in PD patients undergoing functional stereotactic mapping for pallidotomy (eight patients) or subthalamic nucleus deep brain stimulation (four patients)...
  88. pmc Subthalamic nucleus neurons are synchronized to primary motor cortex local field potentials in Parkinson's disease
    Shoichi A Shimamoto
    Departments of Neurological Surgery and Neurology, University of California, San Francisco, California 94143, USA
    J Neurosci 33:7220-33. 2013
    ..implantation surgery, we use the novel technique of subdural electrocorticography in combination with subthalamic nucleus (STN) single-unit recording to study basal ganglia-cortex interactions at the millisecond time scale...
  89. ncbi Subthalamic nucleus stimulation and somatosensory temporal discrimination in Parkinson's disease
    Antonella Conte
    Department of Neurological Sciences, Sapienza University of Rome, Viale dell Universita 30, Rome, Italy
    Brain 133:2656-63. 2010
    ..Dopamine but not subthalamic nucleus deep brain stimulation restores the altered somatosensory temporal discrimination in patients with ..
  90. ncbi Effects of subthalamic nucleus stimulation and levodopa on freezing of gait in Parkinson disease
    M U Ferraye
    Université de Grenoble, INSERM U836, CHU de Grenoble, Pavillon de Neurologie, BP 217, 38043 Grenoble Cedex 9, France
    Neurology 70:1431-7. 2008
    We studied the effects of subthalamic nucleus (STN) stimulation vs levodopa on freezing of gait (FOG) and gait impairments in a large consecutive series of patients with Parkinson disease with bilateral STN stimulation.
  91. ncbi Placebo-controlled chronic high-frequency stimulation of the subthalamic nucleus preserves dopaminergic nigral neurons in a rat model of progressive Parkinsonism
    Daniel Harnack
    Department of Neurology, Campus Virchow, Charite Universitatsmedizin, Augustenburger Platz 1, Berlin, Germany
    Exp Neurol 210:257-60. 2008
    Chronic high-frequency stimulation (HFS) of the subthalamic nucleus (STN) protects nigral dopaminergic neurons from neurodegeneration in animal models of Parkinson's disease (PD)...
  92. pmc Eye movement impairments in Parkinson's disease: possible role of extradopaminergic mechanisms
    Elmar H Pinkhardt
    Department of Neurology, University of Ulm, Oberer Eselsberg 45, 89081 Ulm, Germany
    BMC Neurol 12:5. 2012
    ..However, the present study suggest that dopamine substitution is much less effective in improving oculomotor performance than it is in restoring skeletomotor abilities...
  93. ncbi Effects of subthalamic nucleus stimulation and medication on resting and postural tremor in Parkinson's disease
    Molly M Sturman
    Department of Movement Sciences M C 994, College of Applied Health Sciences, University of Illinois at Chicago, 808 S Wood Street, 690 CME, Chicago, IL 60612, USA
    Brain 127:2131-43. 2004
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and antiparkinsonian medication have proved to be effective treatments for tremor in Parkinson's disease...
  94. pmc Patient-specific analysis of the volume of tissue activated during deep brain stimulation
    Christopher R Butson
    Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH 44195, USA
    Neuroimage 34:661-70. 2007
    ..We used this model system to analyze the effects of subthalamic nucleus (STN) DBS in a patient with Parkinson's disease...
  95. ncbi Long-term recordings of local field potentials from implanted deep brain stimulation electrodes
    Aviva Abosch
    Department of Neurosurgery, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55414, USA
    Neurosurgery 71:804-14. 2012
    Deep brain stimulation (DBS) of the subthalamic nucleus is an effective treatment for Parkinson disease...
  96. ncbi Subthalamic gamma activity in patients with Parkinson's disease
    Thomas Trottenberg
    Department of Neurology, Charité University Medicine Campus Virchow, Humboldt University, Berlin, Germany
    Exp Neurol 200:56-65. 2006
    ..in the gamma frequency (60-100 Hz) band in local field potentials (LFPs) recorded from the region of the subthalamic nucleus (STN)...
  97. ncbi CT/MR image fusion in the postoperative assessment of electrodes implanted for deep brain stimulation
    Ruth L O'Gorman
    Department of Neuroradiology, King s College Hospital, London, UK
    Stereotact Funct Neurosurg 87:205-10. 2009
    ..The purpose of this study was to quantitatively assess the accuracy of three different image registration and fusion methods...
  98. pmc The subthalamic nucleus is one of multiple innervation sites for long-range corticofugal axons: a single-axon tracing study in the rat
    Takako Kita
    Department of Anatomy and Neurobiology, College of Medicine, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    J Neurosci 32:5990-9. 2012
    The frontal cortex provides strong excitatory inputs to the subthalamic nucleus (STN), and these cortico-STN inputs play critical roles in the control of basal ganglia activity...
  99. ncbi Tremor reduction by subthalamic nucleus stimulation and medication in advanced Parkinson's disease
    Christian Blahak
    Department of Neurology, Universitäts klinikum Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurol 254:169-78. 2007
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has proved to be effective for tremor in Parkinson's disease (PD). Most of the recent studies used only clinical data to analyse tremor reduction...
  100. ncbi Optical deconstruction of parkinsonian neural circuitry
    Viviana Gradinaru
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 324:354-9. 2009
    ..circuit elements in freely moving parkinsonian rodents and found that therapeutic effects within the subthalamic nucleus can be accounted for by direct selective stimulation of afferent axons projecting to this region...
  101. ncbi Stimulation of the subthalamic nucleus at an earlier disease stage of Parkinson's disease: concept and standards of the EARLYSTIM-study
    Gunther Deuschl
    Department of Neurology, Universitatsklinikum Schleswig Holstein, Christian Albrechts University, Kiel, Germany
    Parkinsonism Relat Disord 19:56-61. 2013
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for advanced Parkinson's disease (PD) with disabling motor complications...

Research Grants68

  1. Udall Parkinson's Disease Center at Emory University: Circuitry to Therapy
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..is a series of experiments in parkinsonian primates to compare the thalamic effects of pallidal and subthalamic nucleus inactivation and stimulation, as are commonly used to treat advanced parkinsonism in patients, with the ..
  2. Dorsal Column Stimulation as a New Therapy for Motor Disorders
    Miguel A L Nicolelis; Fiscal Year: 2013
    ..striatal lesioned rats implanted with multi-electrode arrays in eight brain areas, including striatum, subthalamic nucleus, globus pallidus, motor and sensory cortices, thalamus, and substantia nigra pars compacta...
  3. Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
    KENNETH J CAMPBELL; Fiscal Year: 2013
    ..to the output nuclei, while the indirect pathway influences the output nuclei via the globus pallidus and subthalamic nucleus. It is believed that balanced output between these two pathways is required for normal brain function...
  4. CRCNS: Propagation of beta oscillations in cortico-basal ganglia-thalamic loop
    Michelle M McCarthy; Fiscal Year: 2013
    ..The efficacy of new treatments such as deep brain stimulation (DBS) to the subthalamic nucleus (STN) or the internal segment of the globus pallidus (GPi) highlights the fact that Parkinson's ..
  5. Synaptic regulation of single substantia nigra pars reticulata neurons
    STEVEN WILLIAM JOHNSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The subthalamic nucleus (STN) plays an important role in movement control by exerting its excitatory influence on the substantia nigra pars reticulata (SNR), a major output structure of the basal ..
  6. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2010
    ..including increase dopamine D2 receptor expression, increased nigral glutamate release from overactive subthalamic nucleus neurons, and decreased nigrostriatal dopamine expression and function)...
  7. Oxidative Stress and Glutamate Excitotoxicity on Aged Dopaminergic Neruons
    Heather A Boger; Fiscal Year: 2013
    ..including increase dopamine D2 receptor expression, increased nigral glutamate release from overactive subthalamic nucleus neurons, and decreased nigrostriatal dopamine expression and function)...
  8. Chronic nicotine: cell-specific receptor and circuit alterations in basal ganglia
    Henry A Lester; Fiscal Year: 2013
    ..b>Subthalamic nucleus (STN) will be studied to confirm preliminary data suggesting that it expresses a* receptors...
  9. Cortical and basal ganglia local field potentials in human movement disorders
    Philip A Starr; Fiscal Year: 2012
    ..Recent studies of subthalamic nucleus (STN) LFPs in Parkinson's disease (PD) produced a novel hypothesis: that parkinsonian bradykinesia is ..
  10. Deep Brain Stimulation in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2012
    ..The areas stimulated will be the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi), two structures now used to treat idiopathic PD ..
  11. DBS of the pedunculopontine nucleus in Parkinsonian primate
    Jerrold L Vitek; Fiscal Year: 2010
    ..Chronic deep brain stimulation (DBS) in the subthalamic nucleus (STN) and the globus pallidus pars internus (GPi) has proven to be an effective therapy for the treatment ..
  12. Aberrant Blink Reflex Motor Learning in a Rat Model of Parkinsons Disease
    JAIME A KAMINER; Fiscal Year: 2013
    ..Deep brain stimulation of the subthalamic nucleus (STN DBS) utilizing regular (130 Hz) or irregular (mean frequency 130 Hz) stimulation will be applied to 6-..
  13. Metabotropic glutamate receptor-mediated synaptic plasticity in the basal ganglia
    KARI JOHNSON; Fiscal Year: 2012
    ..are particularly interested in the role of group II mGluRs (mGluR2 and mGluR3) at the synapse between the subthalamic nucleus (STN) and the substantia nigra pars reticulata (SNr)...
  14. Basal ganglia-thalamic signaling in parkinsonism and deep brain stimulation
    ROBERT STERLING TURNER; Fiscal Year: 2013
    ..Likewise, deep brain stimulation (DBS) of the subthalamic nucleus (STN) may provide relief from parkinsonian signs by suppressing abnormalities in GPi activity...
  15. Synaptic Transmission, Plasticity and Integration in the Subthalamic Nucleus
    Mark D Bevan; Fiscal Year: 2013
    ..neuronal activity in the reciprocally connected GABAergic external globus pallidus (GPe) and glutamatergic subthalamic nucleus (STN) and associated cortico-basal ganglia-thalamocortical networks...
  16. Basal Ganglia Pathways for Stopping and Switching
    Joshua D Berke; Fiscal Year: 2013
    ..STR) appeared to correspond to a Go process, while Stop cues instead provoked very fast responses in the subthalamic nucleus (STN)...
  17. Basal Ganglia Functions in Huntington's Disease: Genetic Mouse Models
    Elizabeth D Abercrombie; Fiscal Year: 2012
    ..Physiological studies of other sites in the basal ganglia (globus pallidus, subthalamic nucleus) will reveal potential "downstream" alterations in the circuitry...
  18. Pathophysiology of Dystonia
    Mark S Baron; Fiscal Year: 2013
    ..discharge activity from large numbers of neurons in single basal ganglia nuclei (GP, EP, and the subthalamic nucleus (STN)) and VL, while simultaneously examining electromyographic activity (EMG) from multiple muscles in ..
  19. Neurocognitive Mechanisms of Inhibition Deficits in Parkinson's Disease
    Scott A Wylie; Fiscal Year: 2013
    ..to underlying neurophysiological mechanisms and determining the effects of treatments (dopamine medication, subthalamic nucleus deep brain stimulation) for PD on behavioral and neurophysiological measures of inhibition...
  20. Rhythmicity and Synchrony in the Basal Ganglia
    DALTON JAMES SURMEIER; Fiscal Year: 2013
    ..Project 3, directed by Dr. Mark Bevan, explores the role of cortical and pallidal input t the subthalamic nucleus in driving oscillatory behavior in Parkinson's disease. Project 4, directed by Dr...
  21. Clinical and neurophysiological study of subthalamic brain stimulation in PD
    HARRISON CARROLL WALKER; Fiscal Year: 2013
    ..The fundamental hypothesis of this proposal is that unilateral subthalamic nucleus (STN) DBS in PD alters neuronal activity in the bilateral basal ganglia-thalamic-cortical motor system in a ..
  22. Aging and Parkinson's Disease: Models of Therapeutics and Neurologic Comorbidity
    Timothy J Collier; Fiscal Year: 2013
    ..and therapy-induced dyskinesias) and mechanisms associated with translational therapeutics (such as subthalamic nucleus DBS and progenitor ceU transplantation)...
  23. Mechanism of Action of Deep Brain Stimulation
    Kendall H Lee; Fiscal Year: 2012
    ..Our recent work demonstrates that subthalamic nucleus (STN) DBS may activate nerve endings to release neurotransmitters, including dopamine...
  24. NMDA receptor NR2D subtype-selective allosteric modulator for the treatment of im
    YUELIAN XU; Fiscal Year: 2013
    ..To address this need, we are developing NR2D PAMs. The subthalamic nucleus (STN) is a brain region that plays a key role in controlling impulsivity...
  25. STN Stimulation: Neural Control of Movement and Posture
    DANIEL MONTIE CORCOS; Fiscal Year: 2011
    High frequency deep brain stimulation of the subthalamic nucleus (STN DBS) dramatically ameliorates most but not all symptoms of Parkinson[unreadable]s disease (PD)...
  26. SYNAPTIC PHARMACOLOGY OF SINGLE SUBTHALAMIC NEURONS
    STEVEN WILLIAM JOHNSON; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The subthalamic nucleus (STN) is composed of glutamate-containing neurons that drive the output of the basal ganglia...
  27. Extrastriatal functions of dopamine
    THOMAS N WICHMANN; Fiscal Year: 2013
    ..Recent studies in animals, primarily rodents) have suggested that dopamine may also act at the level of the subthalamic nucleus (STN)...
  28. MAPPING MOOD IN THE SUBTHALAMIC NUCLEUS IN PD
    TAMARA G HERSHEY; Fiscal Year: 2012
    ..underlying mood complications in PD is to study individuals treated with deep brain stimulation of the subthalamic nucleus (DBS STN). Optimal treatment with DBS STN has significant motor benefits for many PD patients...
  29. Effects of Deep Brain Stimulation on Compulsive Drug Intake
    George F Koob; Fiscal Year: 2012
    ..Recently, deep brain stimulation of the subthalamic nucleus has been proposed has a surgical strategy for obsessive-compulsive disorders, but it has never been tested ..
  30. CORTICAL-SUBCORTICAL INTERACTION IN PD AND NORMAL SPEECH
    John J Sidtis; Fiscal Year: 2013
    ..in brain networks for speech, global brain effects, and/or stimulation of motor tracts adjacent to the subthalamic nucleus. From the speech science perspective, we need to characterize cortical-subcortical interactions for a range ..
  31. Neurophysiological mechanisms underlying parkinsonian motor signs
    Jerrold L Vitek; Fiscal Year: 2012
    ..examined include the internal and external segments of the globus pallidus (GPi and GPe, respectively), the subthalamic nucleus (STN), and the motor thalamus including ventralis anterior, ventralis lateralis pars oralis, and ventralis ..
  32. Mechanisms of Deep Brain Stimulation
    JOEL SYNES PERLMUTTER; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) dramatically improves motor function and quality of life in PD yet may alter cognitive skills and mood (Progress Report)...
  33. Time Course of Subthalamic Deep Brain Stimulation
    Scott E Cooper; Fiscal Year: 2011
    ..The primary goal of the proposed research is to delineate new therapeutic mechanisms of action of Subthalamic nucleus deep brain stimulation (STN DBS)...
  34. How stopping movement affects working memory
    ADAM ROBERT ARON; Fiscal Year: 2013
    ..a rapid motor stop via the brain's global stopping network, b) this network is implemented via the subthalamic nucleus (STN) of the basal ganglia, c) activation of the STN leads to a widespread pulse of suppression on ..
  35. The Role of Orexin and Subthalamic Nucleus in Cocaine Demand
    Brandon S Bentzley; Fiscal Year: 2013
    ..This pathological disparity between natural rewards and drug rewards is reversible in rats by lesioning subthalamic nucleus (STN) bilaterally or by deep brain stimulation (DBS) in STN, as is done for treatment of Parkinson's ..
  36. Subunit-specific NMDA receptor function in the subthalamic nucleus
    SHARON ANN SWANGER; Fiscal Year: 2013
    ..motor symptoms in Parkinson's disease are related to aberrant spike firing of neurons in the subthalamic nucleus (STN), a key structure within the basal ganglia motor circuit...
  37. Comparison of Unilateral and Bilateral Subthalamic Stimulation in Parkinson's
    Jay L Alberts; Fiscal Year: 2012
    ..and motor performance in Parkinson's disease (PD) patients under unilateral compared to bilateral subthalamic nucleus (STN) deep brain stimulation (DBS) during single- and dual-task conditions and to predict the relationship ..
  38. Systems-Level Model of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for the motor symptoms of medically refractory Parkinson's disease (PD)...
  39. BIOGENIC AMINES AND NEUROLOGICAL DISORDERS
    Robert Katzman; Fiscal Year: 1980
    ..2DDG) autoradiography has demonstrated a marked increase in glucose metabolism in pars reticulata and subthalamic nucleus with DA agonists...
  40. NEURONAL PATHWAYS OF THE BASAL GANGLIA
    Hitoshi Kita; Fiscal Year: 2000
    ..nucleus and the substantia nigra pars reticulata, through two different nuclei, the neostriatum and the subthalamic nucleus. The investigators will examine whether stimulation of the sensorimotor cortex induces, in basal ganglia ..
  41. Neural Mechanisms of Behavioral Control
    Veit Stuphorn; Fiscal Year: 2013
    ..might exist in a network of areas in the medial frontal cortex (MFC), inferior frontal cortex (IFC), and subthalamic nucleus (STN)...
  42. Neuronal Activity in MC and SMA during STN and GPi DBS in the Parkinsonian Monkey
    Jerrold L Vitek; Fiscal Year: 2013
    ..Similarly, the effects of DBS in the subthalamic nucleus (STN) and internal segment of the globus pallidus (GPi) on neuronal activity in the MC and SMA are largely ..
  43. PLASTICITY--GAD GENE EXPRESSION IN BASAL GANGLIA
    Marie Francoise Chesselet; Fiscal Year: 2001
    ..Three major sets of neurons will be examined: the subthalamic nucleus, the serotonergic projection from midbrain raphes, and intrastriatal cholinergic neurons...
  44. Neostriatal Visual Processing & Initiation of Movement
    Emad Eskandar; Fiscal Year: 2005
    ..Other important nuclei include the substantia nigra pars compacta and the subthalamic nucleus. The input and output nuclei of the basal ganglia are joined by two distinct sets of connections, known as ..
  45. MOOD EFFECTS OF DEEP BRAIN STIMULATION IN PARKINSONS
    Mark George; Fiscal Year: 2002
    ..from the Applicant's Abstract): Deep Brain Stimulation (DBS) of the thalamus, globus pallidus (GPi) or subthalamic nucleus (STN) is a new treatment for essential tremor and bradykinesia in Parkinson's Disease (PD)...
  46. MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC
    Douglas McCreery; Fiscal Year: 2002
    ..unit action potentials and also capable of stimulating nearby neurons in the globus pallidus and the subthalamic nucleus. In the Type 2 arrays, 9 of the microelectrodes will be designated for recording of unitary neuronal action ..
  47. BASAL GANGLIA FUNCTION--BASIC MECHANISMS AND EFFECTS
    JOHN ASSAD; Fiscal Year: 2004
    ..on movement: a direct pathway from the striatum which facilitates movement, and an indirect pathway via the subthalamic nucleus (STN) which inhibits movement...
  48. CORTICAL ACTIVITY, COGNITIVE AND MOTOR FUNCTION, AND DBS
    WENDY LOMBARDI; Fiscal Year: 2003
    ..humans, by studying the cortical activation on fMRI resulting from stimulation of discrete regions of the subthalamic nucleus and globus pallidus internus, (2) that stimulation of discrete regions of these two nuclei selectively ..
  49. DEEP BRAIN STIMULATION--COGNITION/MOTIVATION/MOOD IN PD
    Marjan Jahanshahi; Fiscal Year: 2005
    DESCRIPTION (Adapted From The Applicant's Abstract): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has been shown to be an effective treatment for the motor symptoms of Parkinson's disease (PD), particularly improving ..
  50. Influence of subthalamic nucleus on striatal dopamine
    Thomas Wichmann; Fiscal Year: 2004
    ..of the nigrostriatal tract in the substantia nigra pars compacta (SNc) is modulated by afferents from the subthalamic nucleus (STN)...
  51. Neural Mechanisms of Reinforcement Learning in the Basal Ganglia
    Kareem Zaghloul; Fiscal Year: 2009
    ..We propose to examine neural activity in the human substantia nigra (SN), subthalamic nucleus (STN), and nucleus accumbens (NA) while patients undergoing DBS are awake and engage in a probabilistic ..
  52. Deep Brain Stimulation in Parkinson's Models
    Marjorie Anderson; Fiscal Year: 2006
    ..provided by applicant): Although high-frequency deep brain stimulation (HF-DBS) in the globus pallidus or subthalamic nucleus has become a common technique used to treat drug-resistant symptoms of Parkinson's disease, the ..
  53. STN STIMULATION--DA TRANSPORTERS & OUTCOME IN PARKINSON'
    Andrew Newberg; Fiscal Year: 2004
    ..system with neuroimaging techniques in patients with Parkinson's disease who are treated with adjunctive subthalamic nucleus (STN) stimulation...
  54. GLUTAMATE IN PARKINSON'S DISEASE
    J Greenamyre; Fiscal Year: 2003
    ..For example, the glutamatergic pathways from subthalamic nucleus to the internal segment of globus pallidus and the substantia nigra pars reticulata become overactive after ..
  55. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..A potential advantage of deep brain stimulation (DBS) of globus pallidus internal (GPi) and the subthalamic nucleus (STN) could be improvement of these axial motor symptoms...
  56. Levodopa dyskinesia and striatal neuroplasticity
    Christine Konradi; Fiscal Year: 2007
    ..In severe cases, neurosurgical lesioning of basal ganglia nuclei such as the thalamus, pallidum or subthalamic nucleus is needed to improve Parkinson's disease and to minimize L-DOPA dosage...
  57. Rat Model of Brain Stimulation in Parkinsonian Condition
    Jing Yu Chang; Fiscal Year: 2005
    ..Array of ten stimulation electrodes will be implanted in the subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr)...
  58. PATHOPHYSIOLOGY OF CHOREA
    Jonathan Mink; Fiscal Year: 2002
    ..neuropathology, chorea has been associated with abnormalities in the striatum (caudate and putamen) and the subthalamic nucleus (STN). However, the fundamental pathophysiology of chorea is not known...
  59. Evaluation of MRI Safety for Deep Brain Stimulation
    Ali Rezai; Fiscal Year: 2004
    ..interest in the use of chronic deep brain stimulation (DBS) of the thalamus, globus pallidus, and the subthalamic nucleus for the treatment of medically refractory movement disorders and other neurological and psychiatric ..
  60. Motor Control Deficits in Parkinson's Disease
    Howard Poizner; Fiscal Year: 2007
    ..to confirm and extend our hypothesis and to investigate the degrees to which deep brain stimulation to the subthalamic nucleus (STN DBS) and DA replacement therapy are able to remediate deficits in sensorimotor control, coordination, ..
  61. Software Guided Localization of the Subthalamic Nucleus During DBS Surgeries
    Peter Novak; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is effective treatment of Parkinson disease...
  62. DBS AND MOTOR CORTICAL FUNCTION IN AN MPTP MODEL OF PD
    Robert Turner; Fiscal Year: 2006
    ..applicant): Deep brain stimulation (DBS) of either the internal segment of the globus pallidus (GPO or the subthalamic nucleus (STN) is an effective treatment for most if not all symptoms of Parkinson's disease (PD)...
  63. Effects of DBS on sensorimotor processes
    Jing Yu Chang; Fiscal Year: 2005
    ..Deep brain stimulation (DBS) of subthalamic nucleus (STN) has been used increasingly in the clinic to alleviate Parkinsonian syndromes (PS) during the past ..
  64. Patient-Specific Models of Deep Brain Stimulation
    Cameron McIntyre; Fiscal Year: 2006
    DESCRIPTION (provided by applicant): Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has rapidly emerged as an effective treatment in medically refractory Parkinson's disease (PD)...
  65. STN Stimulation - Neural Control of Movement and Posture
    Daniel Corcos; Fiscal Year: 2009
    ..High frequency stimulation of the subthalamic nucleus (STN) and dopaminergic medication dramatically improves the motor symptoms of Parkinson's disease...
  66. The Neuroprotective Effects of HF STN-DBS
    Anne Engemann; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): High-frequency deep brain stimulation of the subthalamic nucleus (HF STN-DBS) is now the most frequently practiced surgical therapy for the treatment of Parkinson's disease (PD) with more than ..
  67. Regulation of Globus Pallidus Gene Expression
    LAUREN LUHRS; Fiscal Year: 2003
    ..In addition, the GP has reciprocal projections with the subthalamic nucleus (STN) and with the striatum, and projects directly to the output nuclei of the basal ganglia...
  68. EXPERIMENTAL STUDIES IN SENSORY PATHWAYS
    MARK BEVAN; Fiscal Year: 2004
    ..there has been a growing interest in converging inputs from the tegmental pedunculopontine (PPN) and subthalamic nucleus (STN) to the SNc DA and SNr GABA neurons...