prosencephalon

Summary

Summary: The part of the brain developed from the most rostral of the three primary vesicles of the embryonic neural tube and consisting of the DIENCEPHALON and TELENCEPHALON.

Top Publications

  1. pmc Early steps in the development of the forebrain
    Stephen W Wilson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 6:167-81. 2004
  2. ncbi Control of memory formation through regulated expression of a CaMKII transgene
    M Mayford
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168 Street, New York, NY 10032, USA
    Science 274:1678-83. 1996
  3. ncbi Longitudinal organization of the anterior neural plate and neural tube
    K Shimamura
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Development 121:3923-33. 1995
  4. ncbi Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins
    Takaaki Kuwajima
    Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5383-92. 2006
  5. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
  6. ncbi From waking to sleeping: neuronal and chemical substrates
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Trends Pharmacol Sci 26:578-86. 2005
  7. ncbi Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb
    Ming Ma
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
    J Neurosci 32:10105-16. 2012
  8. ncbi Genetics of ventral forebrain development and holoprosencephaly
    M Muenke
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 1852, USA
    Curr Opin Genet Dev 10:262-9. 2000
  9. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
  10. ncbi Molecular interactions coordinating the development of the forebrain and face
    Ralph S Marcucio
    Department of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305, USA
    Dev Biol 284:48-61. 2005

Research Grants

Detail Information

Publications281 found, 100 shown here

  1. pmc Early steps in the development of the forebrain
    Stephen W Wilson
    Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, United Kingdom
    Dev Cell 6:167-81. 2004
    ..Here, we discuss early events in forebrain development--those that lead to the establishment of the anterior neural plate and the regional subdivision of this territory into the different domains of the prospective forebrain...
  2. ncbi Control of memory formation through regulated expression of a CaMKII transgene
    M Mayford
    Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, and Howard Hughes Medical Institute, 722 West 168 Street, New York, NY 10032, USA
    Science 274:1678-83. 1996
    ..Thus, the CaMKII signaling pathway is critical for both explicit and implicit memory storage, in a manner that is independent of its potential role in development...
  3. ncbi Longitudinal organization of the anterior neural plate and neural tube
    K Shimamura
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Development 121:3923-33. 1995
    ....
  4. ncbi Necdin promotes GABAergic neuron differentiation in cooperation with Dlx homeodomain proteins
    Takaaki Kuwajima
    Laboratory of Regulation of Neuronal Development, Institute for Protein Research, Osaka University, Suita, Osaka 565 0871, Japan
    J Neurosci 26:5383-92. 2006
    ..These results suggest that paternally expressed necdin facilitates the differentiation and specification of GABAergic neurons in cooperation with Dlx homeodomain proteins...
  5. ncbi Genetic enhancement of learning and memory in mice
    Y P Tang
    Department of Molecular Biology, Princeton University, New Jersey 08544 1014, USA
    Nature 401:63-9. 1999
    ..Our results suggest that genetic enhancement of mental and cognitive attributes such as intelligence and memory in mammals is feasible...
  6. ncbi From waking to sleeping: neuronal and chemical substrates
    Barbara E Jones
    Department of Neurology and Neurosurgery, McGill University, Montreal Neurological Institute, Montreal, Quebec H3A 2B4, Canada
    Trends Pharmacol Sci 26:578-86. 2005
    ..Selective enhancement and attenuation of their discharge, transmitter release and postsynaptic actions comprise the substrates for the major stimulant and hypnotic drugs...
  7. ncbi Optogenetic activation of basal forebrain cholinergic neurons modulates neuronal excitability and sensory responses in the main olfactory bulb
    Ming Ma
    Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China
    J Neurosci 32:10105-16. 2012
    ..These results demonstrate strong effects of the basal forebrain cholinergic system on modulating neuronal excitability in the MOB and support the hypothesis that cholinergic activity increases olfactory discrimination capability...
  8. ncbi Genetics of ventral forebrain development and holoprosencephaly
    M Muenke
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892 1852, USA
    Curr Opin Genet Dev 10:262-9. 2000
    ..Perturbation of signaling pathways involving these molecules have been shown to cause holoprosencephaly in humans and other organisms...
  9. ncbi A highly conserved enhancer in the Dlx5/Dlx6 intergenic region is the site of cross-regulatory interactions between Dlx genes in the embryonic forebrain
    T Zerucha
    Loeb Health Research Institute at the Ottawa Hospital and Department of Medicine, University of Ottawa, Ottawa, Ontario K1Y 4E9, Canada
    J Neurosci 20:709-21. 2000
    ..This hypothesis is supported by cotransfection and DNA-protein binding experiments. We propose that the Dlx genes are part of a highly conserved developmental pathway that regulates forebrain development...
  10. ncbi Molecular interactions coordinating the development of the forebrain and face
    Ralph S Marcucio
    Department of Plastic and Reconstructive Surgery, Stanford University School of Medicine, 257 Campus Drive, Stanford, CA 94305, USA
    Dev Biol 284:48-61. 2005
    ....
  11. ncbi Wnt signaling is required at distinct stages of development for the induction of the posterior forebrain
    Michelle M Braun
    Program in Neurobiology and Behavior, Department of Biological Structure, Box 357420, University of Washington, Seattle, WA 98195, USA
    Development 130:5579-87. 2003
    ..Later, continued Wnt signaling resulted in the induction of dT specific markers, but only in tissues that expressed Irx3...
  12. ncbi Modulation power and phase spectrum of natural sounds enhance neural encoding performed by single auditory neurons
    Anne Hsu
    Neuroscience Institute and Department of Physics, University of California, Berkeley, Berkeley, California 94720 1650, USA
    J Neurosci 24:9201-11. 2004
    ..We found that rate distribution and bandwidth but not reliability were responsible for the higher average information rates found for song-like sounds...
  13. ncbi Cholinergic basal forebrain neurons burst with theta during waking and paradoxical sleep
    Maan Gee Lee
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada H3A 2B4
    J Neurosci 25:4365-9. 2005
    ..Through their maximal firing and rhythmic theta discharge during active waking and paradoxical sleep, the cholinergic neurons can thus modulate the cortex to promote activation along with plasticity during these two states...
  14. ncbi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
    ....
  15. pmc Experimental autoimmune encephalomyelitis mobilizes neural progenitors from the subventricular zone to undergo oligodendrogenesis in adult mice
    Nathalie Picard-Riera
    Institut National de la Santé et de la Recherche Médicale U 546, Centre Hospitalier Universitaire Pitie Salpetriere, 105 Boulevard de l Hôpital, 75634 Cedex 13, France
    Proc Natl Acad Sci U S A 99:13211-6. 2002
    ....
  16. ncbi Contributions of an avian basal ganglia-forebrain circuit to real-time modulation of song
    Mimi H Kao
    Keck Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, California 94143 0444, USA
    Nature 433:638-43. 2005
    ..More generally, they suggest that frontal cortical and basal ganglia areas may contribute to motor learning by biasing motor output towards desired targets or by introducing stochastic variability required for reinforcement learning...
  17. pmc Generation of Cre-transgenic mice using Dlx1/Dlx2 enhancers and their characterization in GABAergic interneurons
    Gregory B Potter
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California at San Francisco, San Francisco, CA 94158 2611, USA
    Mol Cell Neurosci 40:167-86. 2009
    ..Finally, we provide the first in vivo evidence that both I12b and URE2 are direct targets of DLX2 and require Dlx1 and Dlx2 expression for proper activity...
  18. ncbi Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells
    Alfredo Quinones-Hinojosa
    Department of Neurological Surgery, Brain Tumor Research Center, Developmental Stem Cell Biology Program, University of California, San Francisco, San Francisco, California 94143 0112, USA
    J Comp Neurol 494:415-34. 2006
    ..Ultrastructural analysis of this layer revealed a remarkable network of astrocytic and ependymal processes. This work provides a basic description of the organization of the adult human SVZ...
  19. ncbi Reelin is a detachment signal in tangential chain-migration during postnatal neurogenesis
    Iris Hack
    NMDA IBDM, CNRS INSERM Université Méditerranée, Campus de Luminy, 13288 Marseille Cedex 9, France
    Nat Neurosci 5:939-45. 2002
    ..Our data provide direct evidence that Reelin acts as a detachment signal, but not a stop or guidance cue. We propose that Reelin may have comparable functions during development...
  20. ncbi Vasculature guides migrating neuronal precursors in the adult mammalian forebrain via brain-derived neurotrophic factor signaling
    Marina Snapyan
    The Cellular Neurobiology Unit, Centre de Recherche Universite Laval Robert Giffard, Quebec, Quebec, Canada G1J 2G3
    J Neurosci 29:4172-88. 2009
    ..Our findings provide new insights into the functional organization of substrates that facilitate the long-distance journey of adult neuronal precursors...
  21. pmc Genetic interplay between the transcription factors Sp8 and Emx2 in the patterning of the forebrain
    Andreas Zembrzycki
    Max Planck Institute of Biophysical Chemistry, Department of Molecular Cell Biology, Am Fassberg, 37077 Goettingen, Germany
    Neural Dev 2:8. 2007
    ..Proper patterning is, therefore, a prerequisite for the generation of optimal functional areas. Only a few factors have been shown to control the genetic networks that establish early forebrain patterning...
  22. pmc Neuronal ensemble bursting in the basal forebrain encodes salience irrespective of valence
    Shih Chieh Lin
    Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA
    Neuron 59:138-49. 2008
    ....
  23. ncbi The logic of gene regulatory networks in early vertebrate forebrain patterning
    Leonardo Beccari
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, C Nicolás Cabrera, 1, Madrid 28049, Spain
    Mech Dev 130:95-111. 2013
    The vertebrate forebrain or prosencephalon is patterned at the beginning of neurulation into four major domains: the telencephalic, hypothalamic, retinal and diencephalic anlagen...
  24. pmc Forebrain GABAergic neuron precursors integrate into adult spinal cord and reduce injury-induced neuropathic pain
    Joao M Braz
    Department of Anatomy, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94158, USA
    Neuron 74:663-75. 2012
    ..Our findings suggest that MGE-derived GABAergic interneurons overcome the spinal cord hyperexcitability that is a hallmark of nerve injury-induced neuropathic pain...
  25. pmc The molecular genetics of holoprosencephaly
    Erich Roessler
    Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892 3717, USA
    Am J Med Genet C Semin Med Genet 154:52-61. 2010
    ....
  26. ncbi Zic2-associated holoprosencephaly is caused by a transient defect in the organizer region during gastrulation
    Nicholas Warr
    Early Development, Mammalian Genetics Unit, MRC Harwell, Oxfordshire OX11 0RD, UK
    Hum Mol Genet 17:2986-96. 2008
    ..The analysis provides genetic evidence that Zic2 functions during organizer formation and that the PCP develops via a multi-step process...
  27. ncbi Cognitive functions of the basal forebrain
    M G Baxter
    Department of Psychology, Harvard University, 984 William James Hall, 33 Kirkland Street, Cambridge, Massachusetts 02138, USA
    Curr Opin Neurobiol 9:178-83. 1999
    ..Recent experiments suggest that these neurons serve a modulatory function in cognition, by optimizing cortical information processing and influencing attention...
  28. ncbi Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates
    Y Murakami
    Department of Biology, Okayama University, Okayama 700 8530, Japan
    Development 128:3521-31. 2001
    ..Major evolutionary changes in the vertebrate brain may have involved local restriction of cell lineages, leading to the establishment of neuromeres...
  29. pmc Retinoic acid from the meninges regulates cortical neuron generation
    Julie A Siegenthaler
    Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA
    Cell 139:597-609. 2009
    ..Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis...
  30. pmc The neural basis of birdsong
    Fernando Nottebohm
    Rockefeller University in New York, New York, USA
    PLoS Biol 3:e164. 2005
    ..Songbirds represent an excellent model system for understanding the neural mechanisms underlying learning...
  31. ncbi In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain
    C M Morshead
    Neurobiology Research Group, Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Development 125:2251-61. 1998
    ..There were calculated to be 1200-1300 cells between the rostral corpus callosum and rostral anterior commissure; these data support a lineage model similar to those based on stem cell behavior in other tissue types...
  32. pmc Dlx1 and Dlx2 control neuronal versus oligodendroglial cell fate acquisition in the developing forebrain
    Magdalena A Petryniak
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158 2611, USA
    Neuron 55:417-33. 2007
    ..Our results identify another role for Dlx genes as modulators of neuron versus oligodendrocyte development in the ventral embryonic forebrain...
  33. ncbi Parvalbumin, calbindin, or calretinin in cortically projecting and GABAergic, cholinergic, or glutamatergic basal forebrain neurons of the rat
    Ivana Gritti
    Dipartimento di Scienze Cliniche L Sacco, Universita degli Studi di Milano, 20157 Milan, Italy
    J Comp Neurol 458:11-31. 2003
    ....
  34. ncbi Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection
    Valérie Fridmacher
    Unité de Biologie Moléculaire de l Expression Génique, Centre National de la Recherche Scientifique 2582, Institut Pasteur, Paris Cedex 15, France
    J Neurosci 23:9403-8. 2003
    ..These data demonstrate for the first time that neuron-restricted ablation of NF-kappaB-driven gene expression increases neurodegeneration. This might lead to the path for new treatments of neurodegenerative diseases...
  35. ncbi The role of DCX and LIS1 in migration through the lateral cortical stream of developing forebrain
    Jilin Bai
    Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269 3156, USA
    Dev Neurosci 30:144-56. 2008
    ..Together, these results confirm that the LCS contributes pyramidal neurons to ventral forebrain structures and reveals that DCX and LIS1 have important functions in this major migratory pathway in the developing forebrain...
  36. ncbi Multiple output pathways of the basal forebrain: organization, chemical heterogeneity, and roles in vigilance
    K Semba
    Department of Anatomy and Neurobiology, Dalhousie University, B3H 4H7, Halifax, NS, Canada
    Behav Brain Res 115:117-41. 2000
    ....
  37. ncbi Regulatory gene expression boundaries demarcate sites of neuronal differentiation in the embryonic zebrafish forebrain
    R Macdonald
    Developmental Biology Research Centre, Randall Institute, Kings College London, England
    Neuron 13:1039-53. 1994
    ..This strip of cells fails to develop in mutant fish in which specification of the ventral CNS is disrupted, suggesting that its development may be regulated by the same inductive pathways that pattern the ventral midline...
  38. ncbi A targeted NKX2.1 human embryonic stem cell reporter line enables identification of human basal forebrain derivatives
    Adam L Goulburn
    Monash Immunology and Stem Cell Laboratories, Monash University, Clayton, Victoria, Australia
    Stem Cells 29:462-73. 2011
    ..These studies highlight the diversity of cell types that can be generated from human NKX2.1(+) progenitors and demonstrate the utility of NKX2.1(GFP/w) hESCs for investigating human forebrain development and neuronal differentiation...
  39. ncbi Abnormal expression of epidermal growth factor and its receptor in the forebrain and serum of schizophrenic patients
    T Futamura
    Molecular Neurobiology, Brain Research Institute, Niigata University, Japan
    Mol Psychiatry 7:673-82. 2002
    ....
  40. ncbi Lhx9: a novel LIM-homeodomain gene expressed in the developing forebrain
    S Retaux
    Laboratoire de Neurochimie Anatomie, Institut des Neurosciences, 75005 Paris, France
    J Neurosci 19:783-93. 1999
    ..Furthermore, Lhx9 protein could act in a combinatorial manner with other LIM-homeodomain factors expressed in overlapping pattern...
  41. pmc Complex and dynamic patterns of Wnt pathway gene expression in the developing chick forebrain
    Robyn Quinlan
    MRC Centre for Developmental Neurobiology, New Hunt s House, Guy s Hospital Campus, King s College, London SE1 1UL, UK
    Neural Dev 4:35. 2009
    ..Wnts are able to activate different intracellular pathways, but which of these pathways become activated in different brain subdivisions also remains enigmatic...
  42. ncbi A genetic switch for epilepsy in adult mice
    Heinz E Krestel
    Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany
    J Neurosci 24:10568-78. 2004
    ....
  43. ncbi The songbird as a model for the generation and learning of complex sequential behaviors
    Michale S Fee
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    ILAR J 51:362-77. 2010
    ..This review presents new techniques, experiments, and findings in areas where songbirds have made significant contributions toward understanding of some of the most fundamental questions in neuroscience...
  44. pmc Hemispheric differences in processing of vocalizations depend on early experience
    Mimi L Phan
    Department of Psychology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Proc Natl Acad Sci U S A 107:2301-6. 2010
    ..We describe specific instances, particularly in males, where these lateral differences show an influence of auditory experience with song and/or the bird's own voice during development...
  45. ncbi Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain
    Nicole H Wilson
    Discipline of Anatomy and Developmental Biology, School of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia
    Dev Biol 296:485-98. 2006
    ....
  46. ncbi Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain
    Anil Bagri
    Department of Anatomy, Howard Hughes Medical Institute, CA, USA
    Neuron 33:233-48. 2002
    ....
  47. ncbi Local retinoid signaling coordinates forebrain and facial morphogenesis by maintaining FGF8 and SHH
    R A Schneider
    Department of Orthopaedic Surgery, 533 Parnassus Avenue, Suite U-453, University of California at San Francisco, San Francisco, CA 94143-0514, USA
    Development 128:2755-67. 2001
    ..We propose that the local source of retinoic acid in the rostral head initiates a regulatory cascade that coordinates forebrain and frontonasal process morphogenesis...
  48. pmc Enhanced odor discrimination and impaired olfactory memory by spatially controlled switch of AMPA receptors
    Derya R Shimshek
    Max Planck Institut fur medizinische Forschung, Heidelberg, Germany
    PLoS Biol 3:e354. 2005
    ..Thus, correlated differences in behavior and levels of GluR-B expression allowed a mechanistic and spatial dissection of olfactory learning, discrimination, and memory capabilities...
  49. ncbi Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult
    Cornelius Gross
    Center for Neurobiology and Behavior, Columbia University, New York 10032, USA
    Nature 416:396-400. 2002
    ..In addition, the normal role of the serotonin1A receptor during development may be different from its function when this receptor is activated by therapeutic intervention in adulthood...
  50. ncbi Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries
    A Bulfone
    Department of Psychiatry, University of California, San Francisco 94143 0984
    J Neurosci 13:3155-72. 1993
    ..These findings are consistent with neuromeric theories of forebrain development, and based upon them we suggest a model for forebrain segmentation...
  51. ncbi Patterning of the embryonic forebrain
    J L Rubenstein
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143 0984, USA
    Curr Opin Neurobiol 8:18-26. 1998
    ..e. cerebral cortex, basal ganglia, thalamus, and hypothalamus) are formed, and how molecular lesions in these processes cause human birth defects...
  52. ncbi Differential responsiveness in brain and behavior to sexually dimorphic long calls in male and female zebra finches
    Sharon M H Gobes
    Behavioural Biology and Helmholtz Institute, Utrecht University, 3508 TB Utrecht, The Netherlands
    J Comp Neurol 516:312-20. 2009
    ..Thus, male and female zebra finches both show a behavioral preference for female calls, but differential neuronal activation in response to sexually dimorphic calls...
  53. pmc The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo
    JULIET K KNOWLES
    Department of Neurology and Neurological Science, Stanford University, Stanford, California 94305, USA
    J Neurosci 29:10627-37. 2009
    ....
  54. pmc Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly
    Xin Geng
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Dev Cell 15:236-47. 2008
    ..These results identify Six3 as a direct regulator of Shh expression and reveal a crossregulatory loop between Shh and Six3 in the ventral forebrain...
  55. ncbi Ectopic expression of the Dlx genes induces glutamic acid decarboxylase and Dlx expression
    Thorsten Stühmer
    Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, LPPI, University of California at San Francisco, 401 Parnassus Avenue, San Francisco, CA 94143 0984, USA
    Development 129:245-52. 2002
    ..We also used this method to show cross-regulation between different Dlx family members. We find that Dlx2 can induce Dlx5 expression, and that Dlx1, Dlx2 and Dlx5 can induce expression from a Dlx5/6-lacZ enhancer/"reporter construct...
  56. ncbi Response biases in auditory forebrain regions of female songbirds following exposure to sexually relevant variation in male song
    T Q Gentner
    Department of Psychology, Behavioral Neuroendocrinology Group, Johns Hopkins University, 3400 N Charles St, Baltimore, Maryland 21218, USA
    J Neurobiol 46:48-58. 2001
    ..Therefore, the results of this study strongly implicate NCM in at least a portion of the perceptual processes underlying the complex natural behavior of female choice...
  57. ncbi Release of hypocretin (orexin) during waking and sleep states
    Lyudmila I Kiyashchenko
    Department of Psychiatry and Biobehavioral Sciences and Brain Research Institute, University of California Los Angeles School of Medicine, North Hills, California 91343, USA
    J Neurosci 22:5282-6. 2002
    ..Hcrt-1 release into CSF was 67% higher during AW than during QW. Elevated levels of Hcrt during REM sleep and AW are consistent with a role for Hcrt in the central programming of motor activity...
  58. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  59. pmc Zic1 and Zic4 regulate zebrafish roof plate specification and hindbrain ventricle morphogenesis
    Gina E Elsen
    The Committee on Neurobiology, University of Chicago, 947 East 58th Street, Chicago, IL 60637, USA
    Dev Biol 314:376-92. 2008
    ..In summary, we conclude that Zic1 and Zic4 control zebrafish 4th ventricle morphogenesis by regulating multiple mechanisms including cell proliferation and fate specification in the dorsal hindbrain...
  60. ncbi Unique and combinatorial functions of Fgf3 and Fgf8 during zebrafish forebrain development
    Jennifer Walshe
    MRC Centre for Developmental Neurobiology, King s College London, London SE1 1UL, UK
    Development 130:4337-49. 2003
    ..Analysis of embryos treated with an FGFR inhibitor suggests that continuous FGF signalling is required from gastrulation stages for normal forebrain patterning, and identifies additional requirements for FGFR activity...
  61. pmc Behaviourally driven gene expression reveals song nuclei in hummingbird brain
    E D Jarvis
    Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nature 406:628-32. 2000
    ....
  62. ncbi Increased generation of neuronal progenitors after ischemic injury in the aged adult human forebrain
    Jadranka Macas
    Institute of Neurology Edinger Institute, University of Frankfurt, D 60528 Frankfurt, Germany
    J Neurosci 26:13114-9. 2006
    ..These results suggest that the adult human brain retains a capacity to respond to ischemic injuries and that this capacity is maintained even in old age...
  63. pmc Interneuron progenitors attenuate the power of acute focal ictal discharges
    Estanislao De La Cruz
    Department of Neurological Surgery, Weill Cornell Medical College, New York Presbyterian Hospital, New York, NY 10065, USA
    Neurotherapeutics 8:763-73. 2011
    ..As remarkably low graft densities still significantly reduced discharge power, these data provide further support for the therapeutic potential of interneuron precursor transplants in the treatment of neocortical epilepsy...
  64. pmc Changes in the neural control of a complex motor sequence during learning
    Bence P Olveczky
    McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Neurophysiol 106:386-97. 2011
    ..As learning proceeds and the motor circuits mature, the relative contribution of LMAN is reduced, allowing the premotor input from HVC to drive an increasingly stereotyped song...
  65. ncbi Radial glial identity is promoted by Notch1 signaling in the murine forebrain
    N Gaiano
    Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, USA
    Neuron 26:395-404. 2000
    ..These results suggest that Notch1 promotes radial glial identity during embryogenesis, and that radial glia may be lineally related to stem cells in the adult nervous system...
  66. ncbi Stabilizing the regionalisation of the developing vertebrate central nervous system
    Andrea Pasini
    Division of Developmental Neurobiology, National Institute for Medical Research, London
    Bioessays 24:427-38. 2002
    ..We review the evidence for these mechanisms at distinct boundaries in the developing vertebrate central nervous system, and discuss what is known about their molecular mediators...
  67. ncbi Otx2 is required to respond to signals from anterior neural ridge for forebrain specification
    E Tian
    Department of Morphogenesis, Kumamoto University, Honjo 2 2 1, Kumamoto, 860 0811, Japan
    Dev Biol 242:204-23. 2002
    ..These results further suggest that Otx2 dosage may be crucial in the neural plate with respect to response to inductive signals primarily from the ANR for forebrain specification...
  68. ncbi Distribution of leptin-sensitive cells in the postnatal and adult mouse brain
    Emilie Caron
    INSERM, U837, Jean Pierre Aubert Research Center, Lille Cedex, 59045, France
    J Comp Neurol 518:459-76. 2010
    ..They also identify regions where LepRb mRNA is expressed during early postnatal life and suggest new roles for leptin in the nervous system during development...
  69. pmc Song environment affects singing effort and vasotocin immunoreactivity in the forebrain of male Lincoln's sparrows
    Kendra B Sewall
    Department of Biology, University of North Carolina, Chapel Hill, NC 27599, USA
    Horm Behav 58:544-53. 2010
    ....
  70. ncbi Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway
    Jack M Parent
    Department of Neurology, University of Michigan Medical Center, Ann Arbor, Michigan 48104, USA
    J Neurosci 22:3174-88. 2002
    ..Identification of the mechanisms underlying the response of neural progenitors to seizure-induced injury may help to advance brain regenerative therapies by using either transplanted or endogenous neural precursor cells...
  71. ncbi Prenatal exposure to the acetylcholinesterase inhibitor methanesulfonyl fluoride alters forebrain morphology and gene expression
    Donna M Byers
    Department of Biological Sciences, University of Texas at El Paso, 500 W University Avenue, El Paso, TX 79968, USA
    Brain Res Dev Brain Res 158:13-22. 2005
    ..The changes observed in cortical morphology and gene expression suggest a critical developmental role for AChE in the fetal nervous system, most likely through its effect on cholinergic neurotransmission...
  72. pmc Atrophy of the cholinergic Basal forebrain over the adult age range and in early stages of Alzheimer's disease
    Michel Grothe
    Department of Psychiatry, University Rostock, Germany
    Biol Psychiatry 71:805-13. 2012
    ..However, there is a controversy regarding how the cholinergic lesion in AD relates to early and incipient stages of the disease. In vivo imaging studies on the structural integrity of the BFCS in normal and pathologic aging are rare...
  73. ncbi Expression of constitutively active FoxO3 in murine forebrain leads to a loss of neural progenitors
    Uta Schmidt-Strassburger
    Institute of Physiological Chemistry, Ulm University, Albert Einstein Allee 11, 89081 Ulm, Germany
    FASEB J 26:4990-5001. 2012
    ..We therefore conclude that neural progenitors are particularly vulnerable to FOXO3-induced apoptosis, which is mediated by PIK3IP1, a negative PI3 kinase regulator...
  74. ncbi The morphogen signaling network in forebrain development and holoprosencephaly
    Edwin S Monuki
    Department of Pathology and Laboratory Medicine, UC Irvine School of Medicine, University of California Irvine, Irvine, CA 92697, USA
    J Neuropathol Exp Neurol 66:566-75. 2007
    ....
  75. ncbi The prechordal region lacks neural inducing ability, but can confer anterior character to more posterior neuroepithelium
    A C Foley
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 124:2983-96. 1997
    ..The competence of neuroectoderm to respond to anteriorizing signals declines by stages 7-9, but both posteriorizing signals and the ability of neuroectoderm to respond to them persist after this stage...
  76. ncbi Roles of the mammalian subventricular zone in brain development
    Christine Y Brazel
    Department of Neuroscience and Anatomy, H109 Pennsylvania State University College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Prog Neurobiol 69:49-69. 2003
    ..This review provides a critical analysis of the literature, from which current and future studies on the SVZ can be formulated and evaluated...
  77. ncbi Sox2-mediated differential activation of Six3.2 contributes to forebrain patterning
    Leonardo Beccari
    Centro de Biologia Molecular Severo Ochoa, CSIC UAM, c Nicolas Cabrera 1, Madrid 28049, Spain
    Development 139:151-64. 2012
    ..They also demonstrate that graded levels of the same TF, probably operating in partially independent transcriptional networks, pattern the vertebrate forebrain along the anterior-posterior axis...
  78. ncbi Roles of organizer factors and BMP antagonism in mammalian forebrain establishment
    Yu Ping Yang
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
    Dev Biol 296:458-75. 2006
    ..These results lead to a model in which BMP antagonism supplied by exogenous tissues promotes forebrain establishment and maintenance in the murine ectoderm...
  79. pmc Sleep and sensorimotor integration during early vocal learning in a songbird
    Sylvan S Shank
    Department of Psychology, University of Chicago, Chicago, Illinois 60637, USA
    Nature 458:73-7. 2009
    ..By this hypothesis, adaptive changes driven by replay of sensory information at night and by evaluation of sensory feedback during the day interact to produce the complex circadian patterns seen early in vocal development...
  80. ncbi Auditory feedback in learning and maintenance of vocal behaviour
    M S Brainard
    Keck Center for Integrative Neuroscience, Departments of Physiology and Psychiatry, University of California San Francisco, San Francisco, California 94143 0444, USA
    Nat Rev Neurosci 1:31-40. 2000
    ....
  81. pmc An avian basal ganglia-forebrain circuit contributes differentially to syllable versus sequence variability of adult Bengalese finch song
    Cara M Hampton
    Keck Center for Integrative Neuroscience, University of California, San Francisco, CA 94143 0444, USA
    J Neurophysiol 101:3235-45. 2009
    ..These results show that LMAN contributes differentially to syllable versus sequence variability of adult song and suggest that these forms of variability are regulated by distinct neural pathways...
  82. ncbi Forebrain gene expression domains and the evolving prosomeric model
    Luis Puelles
    Department of Human Anatomy and Psychobiology, Faculty of Medicine, University of Murcia, Murcia 30100, Spain
    Trends Neurosci 26:469-76. 2003
    ..We sketch a simplified model, in which the secondary prosencephalon (telencephalon plus hypothalamus) is a complex protosegment not subdivided into prosomeres, which exhibits ..
  83. ncbi Regulation of postnatal forebrain amoeboid microglial cell proliferation and development by the transcription factor Runx1
    Morena Zusso
    Montreal Neurological Institute, McGill University, Montreal, Quebec, H3A 2B4 Canada
    J Neurosci 32:11285-98. 2012
    ..These findings provide insight into the regulation of postnatal microglia activation and maturation to the ramified state and have implications for microglia biology in the developing and injured brain...
  84. pmc New findings for phenotype-genotype correlations in a large European series of holoprosencephaly cases
    Sandra Mercier
    Service de génétique clinique, CLAD Ouest, CHU Rennes, Rennes, France
    J Med Genet 48:752-60. 2011
    Holoprosencephaly (HPE) is the most common forebrain defect in humans. It results from incomplete midline cleavage of the prosencephalon.
  85. ncbi Consequences of neural cell adhesion molecule deficiency on cell migration in the rostral migratory stream of the mouse
    G Chazal
    Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, Centre National de la Recherche Scientifique Université de la Santé et de la Recherche Medicale, INSERM, Paris Cedex, France
    J Neurosci 20:1446-57. 2000
    ....
  86. ncbi Cxcl10 enhances blood cells migration in the sub-ventricular zone of mice affected by experimental autoimmune encephalomyelitis
    Luca Muzio
    Neuroimmunology Unit, DIBIT 2, Institute of Experimental Neurology INSPE, Division of Neuroscience, San Raffaele Scientific Institute, 20132 Milano, Italy
    Mol Cell Neurosci 43:268-80. 2010
    ..Finally, we show, by RT-PCR and in situ hybridization, that Cxcl10 is expressed also in the healthy human SvZ, suggesting a possible molecular parallelism between multiple sclerosis and EAE...
  87. ncbi Expression mapping of 5-HT1 serotonin receptor subtypes during fetal and early postnatal mouse forebrain development
    A Bonnin
    Department of Pharmacology, Vanderbilt University, 8114 MRBIII, 465 21st Avenue South, Nashville, TN 37232 8548, USA
    Neuroscience 141:781-94. 2006
    ..Moreover, all members of the 5-HT1 receptor class are strongly and transiently expressed in the embryonic dorsal thalamus, which suggests a potential role for serotonin in early thalamic development...
  88. ncbi Neuroanatomical and behavioral effects of a novel version of the cholinergic immunotoxin mu p75-saporin in mice
    Pierre Henri Moreau
    Laboratoire d Imagerie et de Neurosciences Cognitives, UMR7191 CNRS, Equipe de Neurobiologie Cognitive et Comportementale, ULP, IFR 37 de Neurosciences, GDR 2905 CNRS, 12 rue Goethe, 67000 Strasbourg, France
    Hippocampus 18:610-22. 2008
    ..These behavioral consequences are comparable, with fewer side effects, to those reported after ICV 192 IgG-saporin in rats. In conclusion, the new version of mu p75-saporin provides a safe and powerful tool for BFCN lesion in mice...
  89. pmc BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning
    Yu Ping Yang
    Department of Cell Biology, Duke University Medical Center, Durham, NC 27710 3709, USA
    Hum Mol Genet 19:3030-42. 2010
    ....
  90. ncbi Glutamatergic stimulation of the basal forebrain elevates extracellular adenosine and increases the subsequent sleep
    H K Wigren
    Institute of Biomedicine Physiology, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland
    Neuroscience 147:811-23. 2007
    ..These results indicate that increased neuronal activity in the BF, and particularly the type of neuronal activity coinciding with active waking, is one of the factors contributing to the buildup of the sleep pressure...
  91. ncbi A specialized forebrain circuit for vocal babbling in the juvenile songbird
    Dmitriy Aronov
    McGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 320:630-4. 2008
    ..Thus, juvenile singing is driven by a circuit distinct from that which produces the adult behavior-a separation possibly general to other developing motor systems...
  92. pmc The time course of adenosine, nitric oxide (NO) and inducible NO synthase changes in the brain with sleep loss and their role in the non-rapid eye movement sleep homeostatic cascade
    Anna V Kalinchuk
    Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System and Harvard Medical School, West Roxbury, Massachusetts, USA
    J Neurochem 116:260-72. 2011
    ..These data support the role of BF adenosine and NO in sleep homeostasis and indicate the temporal and spatial sequence of sleep homeostatic cascade for NO and adenosine...
  93. ncbi Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus
    Abdulhakeem A Al-Majed
    Department of Pharmacology, College of Pharmacy, King Saud University, P O Box 2457, Riyadh 11451, Saudi Arabia
    Eur J Pharmacol 543:40-7. 2006
    ..This spectacular protection makes thymoquinone a promising agent in pathologies implicating neurodegenaration such as cerebral ischemia...
  94. ncbi The diurnal rhythm of adenosine levels in the basal forebrain of young and old rats
    E Murillo-Rodriguez
    Department of Neurology, West Roxbury VA Medical Center and Harvard Medical School, Building 3, Room 2C109, 1400 VFW Parkway, West Roxbury, MA 02132, USA
    Neuroscience 123:361-70. 2004
    ....
  95. ncbi Chain formation and glial tube assembly in the shift from neonatal to adult subventricular zone of the rodent forebrain
    Paolo Peretto
    Department of Animal and Human Biology, University of Turin, 10153 Turin, Italy
    J Comp Neurol 487:407-27. 2005
    ..The attainment of an adult SVZ compartmentalization, on the other hand, seems linked to the pattern of expression of adhesion and extracellular matrix molecules...
  96. pmc Efficient in vivo electroporation of the postnatal rodent forebrain
    Camille Boutin
    IBDML, CNRS Université de Méditerranée, Campus de Luminy, Marseille, France
    PLoS ONE 3:e1883. 2008
    ..Second, we demonstrate that p21 acts as a cell cycle inhibitor for postnatal neural stem cells. This approach will represent an important tool for future studies of postnatal neurogenesis and of neural development in general...
  97. pmc Sonic hedgehog mutations identified in holoprosencephaly patients can act in a dominant negative manner
    Samer Singh
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, NH 03755, USA
    Hum Genet 125:95-103. 2009
    ..of sporadic and inherited holoprosencephaly (HPE), a developmental disorder that is characterized by defective prosencephalon development...
  98. ncbi Feature analysis of natural sounds in the songbird auditory forebrain
    K Sen
    Sloan Center for Theoretical Neuroscience, University of California, 513 Parnassus Ave, Berkeley, CA 94720 1650, USA
    J Neurophysiol 86:1445-58. 2001
    ....
  99. ncbi Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain
    Gwendolyn E Goings
    Children s Memorial Research Center, Neurobiology Program, Children s Memorial Hospital, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Glia 54:329-42. 2006
    ..Our data show that both constitutive and postlesion levels of microglial activation differ between neurogenic and non-neurogenic regions...
  100. pmc Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer's disease
    Michel Grothe
    Laboratory of Functional Neuroscience, Spanish Network of Excellence in Neurodegenerative Diseases, CIBERNED, University Pablo de Olavide, 41013 Seville, Spain
    Cereb Cortex 20:1685-95. 2010
    ..These findings establish, for the first time, a link between degeneration of specific cholinergic compartments of the BFCS and cognitive-related deficits in subjects at high risk of developing AD...
  101. pmc The LIM-homeobox gene Islet-1 is required for the development of restricted forebrain cholinergic neurons
    Yasser Elshatory
    Medical Scientist Training Program, Department of Ophthalmology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    J Neurosci 28:3291-7. 2008
    ..Together, these results demonstrate the requirement for Isl1 in the development of restricted telencephalic cholinergic neurons and link the development of cholinergic neurons in anatomically disparate sites to Isl1 function...

Research Grants68

  1. THE ROLE OF THE HOMEOBOX SIX3 IN HOLOPROSENCEPHALY/CYCLOPIA
    Guillermo Oliver; Fiscal Year: 2009
    ..is the most common embryologic malformation of the forebrain in humans caused by incomplete cleavage of the prosencephalon. This malformation which affects the development of the prechordal plate and anterior neuroectoderm includes ..
  2. TRAINING IN AGE-RELATED NEURODEGENERATIVE DISEASES
    Elliott Mufson; Fiscal Year: 2008
    ..Finally the program will provide a broad-base of knowledge on neurodegenerative disorders as well as other instruction important for enhancing the interpersonal and professional skills of our trainees. ..
  3. LPH to VTA Neurotensin: Actions and Cocaine Effects
    DANIEL ZAHM; Fiscal Year: 2004
    ..The data may lead to better, more selective therapeutic approaches to prevention of psychostimulant sensitization, which is thought play a significant role in destructive drug seeking behaviors. ..
  4. Form/function of Extended Amygdala/Accumbens Shell:CRF
    DANIEL ZAHM; Fiscal Year: 2005
    ....
  5. CDP-choline: Mechanisms in Cerebral Ischemia
    RAO ADIBHATLA; Fiscal Year: 2006
    ..Arachidonic acid activates neutral sphingomyelinase, resulting in membrane disintegration. PCCT activity was stimulated by exogenous CDP-choline. Aim 2 will be tested in gerbil transient forebrain ischemia. ..
  6. ATTENTION, CORTICAL ACH RELEASE AND NEURONAL ACTIVITY
    Martin Sarter; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  7. Neural basis of heritable DA-mediated gating deficits
    Neal R Swerdlow; Fiscal Year: 2010
    ....
  8. INTRALAMINAR THALAMIC INFLUENCES ON VISUAL AWARENESS
    Nicholas Schiff; Fiscal Year: 2004
    ..While these are long-range goals, and the studies proposed here do not represent direct investigations of these possibilities, completion of these experiments is necessary and logical step toward these goals. ..
  9. Lesion Induced Synaptic Plasticity
    STEPHEN GINSBERG; Fiscal Year: 2004
    ....
  10. NEURAL CIRCUITRY OF SENSORIMOTOR GATING ACROSS SPECIES
    Neal Swerdlow; Fiscal Year: 2006
    ....
  11. Cholinergic plasticity in auditory input processing
    Martin Sarter; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  12. Amphetamine, cortical acetylcholine and cognition
    Martin Sarter; Fiscal Year: 2006
    ..abstract_text> ..
  13. Neuroscience at the Boundaries of Neurology and Psychiatry
    Neal Swerdlow; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  14. A Simple Measure for Studying Sensory Gating Deficits
    Neal Swerdlow; Fiscal Year: 2007
    ..abstract_text> ..
  15. In vivo screening of cholinergic cognition enhancers
    Martin Sarter; Fiscal Year: 2008
    ..The development of new drug finding [unreadable] [unreadable] [unreadable]..
  16. CORTICO-STRIATAL SUBSTRATES OF DEFICIENT STARTLE GATING
    Neal R Swerdlow; Fiscal Year: 2010
    ..New information from these studies will be a foundation for innovative models of the pathophysiology of schizophrenia and other inherited neuropsychiatric disorders, and for prospective strategies for novel drug development. ..
  17. Nicotinic regulation of cortical ACh release and behavioral function
    MARTIN F SARTER; Fiscal Year: 2010
    ..This research will reveal critical neuronal and cognitive mechanisms underlying the pro-cognitive effects of nicotinic receptor ligands and thereby assist in defining and predicting the clinical potential of this group of compounds. ..
  18. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  19. AGING, ATTENTION AND BENZODIAZEPINE RECEPTOR LIGANDS
    Martin Sarter; Fiscal Year: 2002
    ....
  20. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  21. MULTIDISCIPLINARY ASSESSMENT OF SEVERE BRAIN INJURY
    Nicholas Schiff; Fiscal Year: 2003
    ..The long-range goal of the studies proposed here is to provide a foundation for rational therapies for chronic cognitive disabilities following complex brain injuries. ..
  22. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  23. Molecular Diagnosis Utilizing Cerebrospinal Fluid
    STEPHEN GINSBERG; Fiscal Year: 2003
    ..abstract_text> ..
  24. Regulation of cortical ACh and Cognition
    Martin Sarter; Fiscal Year: 2008
    ..The renewal of the KO2 would allow this candidate to devote at least 75% of his time for multidisciplinary research on the neurobiology of attentional functions. ..
  25. Cellular Mechanisms of Vocal-Respiratory Integration
    Richard Mooney; Fiscal Year: 2005
    ..abstract_text> ..
  26. Lamina I and Homeostasis
    Arthur Craig; Fiscal Year: 2005
    ..The fundamental knowledge will provide new opportunities for explaining maladaptive homeostatic responses to somatic physiological changes, including such human pathological conditions as fibromyalgia. ..
  27. Neuropathology and Pathogenesis of Huntington's Disease
    Anton Reiner; Fiscal Year: 2008
    ..abstract_text> ..
  28. KETOGENIC DIET AND BRAIN AMINO ACID METABOLISM
    Marc Yudkoff; Fiscal Year: 2002
    ....
  29. ENCODING OF VOCAL SIGNALS IN THE AUDITORY SYSTEM
    Andrew H Bass; Fiscal Year: 2011
    ..with auditory; neuropathy/dys-synchrony.. '-.'...... ..
  30. HINDBRAIN AND NEUROPEPTIDE Y--CONTROL OF FOOD INTAKE
    ERIC CORP; Fiscal Year: 2002
    ..Results will contribute to the overall understanding of the neurobiology underlying obesity and eating disorders. ..
  31. Modulation of auditory processing by behavioral state
    Marc Schmidt; Fiscal Year: 2009
    ..We hypothesize that the behavioral context with which the heard song is produced as well as the identity of the singer will significantly influence auditory responses. ..
  32. Sympathetic-Immune Interface: Central Sites & Function
    MICHAEL KENNEY; Fiscal Year: 2005
    ..Ultimately, these findings may allow for the design of intervention strategies in immune regulation fostering robust and appropriate communication between the immune and nervous systems. ..
  33. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..adult rats, and should evolve new principles for improved treatments for childhood-onset schizophrenia and other major pediatric psychiatric disorders. ..
  34. Fine Structure of Lamina I TSST Terminals in VP
    Arthur Craig; Fiscal Year: 2004
    ..These studies will advance our understanding of the anatomical substrates for pain sensation in the primate thalamus. ..
  35. Physiology of Lamina I and V STT Cells
    Arthur Craig; Fiscal Year: 2005
    ..This research will provide new insights into the synergy between lamina I and V STT neurons and into the integration underlying pain, temperature and itch sensations that is altered in clinical disorders. ..
  36. Adult Forebrain Neural Stem Cell Response to Ischemia
    Jack Parent; Fiscal Year: 2005
    ..Progress in these Aims will advance our understanding of adult SVZ neurogenesis in the normal and ischemic brain, and may provide insight into the potential use of neural stem cells for stroke therapy. ..
  37. CaMKI, Apoptosis and Cholinergic Neurons in Aging and AD
    Changiz Geula; Fiscal Year: 2007
    ..They will also form the basis of more comprehensive future studies aimed at determining the causes and effects of the alterations of the above genes. [unreadable] [unreadable] [unreadable]..
  38. Novel pharmacotherapies for treatment of ADHD
    FRANK TARAZI; Fiscal Year: 2003
    ..Expected findings should evolve new principles and lead to novel compounds that can be used as much-needed innovative treatments for ADHD and other major neuropsychiatric disorders. ..
  39. Hybrid Drugs: Novel Pharmacotherapy for ADHD
    FRANK TARAZI; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. SENESCENCE ALTERS SYMPATHETIC REGULATION TO HEAT STRESS
    MICHAEL KENNEY; Fiscal Year: 2004
    ..The proposed studies will, for the first time, advance the hypothesis that the working strategies employed by sympathetic neural circuits to respond to heat stress are modified by aging. ..
  41. Central Mechanisms of Opiate Reinforcement and Dependence
    George Koob; Fiscal Year: 2008
    ....
  42. Isolation and Characterization of Cholinesterases From Plaques and Tangles
    Changiz Geula; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  43. Norepinephrine Transporters: Targets for ADHD
    FRANK TARAZI; Fiscal Year: 2004
    ..Expected findings should lead to novel compounds that can be developed as much needed innovative non-stimulant treatments for ADHD and other major neuropsychiatric disorders. ..
  44. Molecular Mechanisms of Receptor Function in SE
    SEVERN CHURN; Fiscal Year: 2005
    ..Understanding the cellular mechanisms that result in altered GABAAR function in SE is essential to the development of new treatment strategies to manage SE in the clinical setting. ..
  45. DEVELOPMENT OF THE OLFACTORY SYSTEM IN ZEBRAFISH
    KATHLEEN WHITLOCK; Fiscal Year: 2004
    ..abstract_text> ..
  46. Effort-related Functions of Nucleus Accumbens Adenosine A2A Receptors
    John D Salamone; Fiscal Year: 2010
    ....
  47. BEHAVIORAL EFFECTS OF NIGRAL D1 ANTAGONISM
    John Salamone; Fiscal Year: 2001
    ....
  48. Augmentation of Neurogenesis and Recovery After Stroke
    Jack Parent; Fiscal Year: 2007
    ..Progress in these aims will advance our understanding of mechanisms underlying neural stem cell regulation and rehabilitative plasticity after brain injury, and may lead to novel regenerative therapies for stroke. ..
  49. Dopamine D2 and Adenosine A2A roles:Tremulous Movements
    John Salamone; Fiscal Year: 2007
    ..abstract_text> ..
  50. Dopamine D4 Receptor in Sustained Attention
    Kehong Zhang; Fiscal Year: 2003
    ..The findings may also provide a pharmacological basis for innovative treatment for ADHD to replace stimulant therapy. ..
  51. Neurogenesis in the Human Brain
    Alfredo Quinones Hinojosa; Fiscal Year: 2003
    ....
  52. Sound Source Segregation and the Cocktail Party Problem in a Non-human Vertebrate
    MARK BEE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  53. FUNCTIONAL ORGANIZATION OF THE VAGAL-ENTERIC INTERFACE
    Hans Rudolf Berthoud; Fiscal Year: 2003
    ..abstract_text> ..
  54. MOTOR EFFECTS OF ATYPICAL ANTIPSYCHOTICS
    John Salamone; Fiscal Year: 2003
    ..Taken together, the results of these experiments will help to identify the pharmacological characteristics and brain circuits that underlie the motor effects of clozapine. ..
  55. Single neuron correlates of learned song
    Richard Mooney; Fiscal Year: 2004
    ..This project can help identify neural mechanisms important to audition guided vocal learning, and thus may yield insight into neural mechanisms for speech learning, perception and production. ..
  56. HORMONES, BRAIN FUNCTION, AND BEHAVIOR
    George Wade; Fiscal Year: 2007
    ..A third proposed line of research examines the effects of metabolic fuel availability on matern',_ behavior in hamsters. ..
  57. Sex Differences and Incubation of Cocaine Craving
    TOD KIPPIN; Fiscal Year: 2005
    ..These initial experiments will form the bases of subsequent studies examining the organizational and activational effects of gonadal hormones and the neuroendocrine bases of sex differences in time-dependent neuroadaptations. ..
  58. Neurobehavioral Effects of MDMA in Adolescent Monkeys
    Craig Ferris; Fiscal Year: 2009
    ..The goal of this work is to better understand the risks of adolescent MDMA exposure on brain function, psychosocial and cognitive development. ..
  59. FUNCTIONAL MRI OF MOTIVATION IN NONHUMAN PRIMATES
    Craig Ferris; Fiscal Year: 2002
    ..There are no effective psychosocial intervention strategies or drug treatments to help violent sex offenders. This is an extremely important area of mental health that impacts on public safety and criminal corrections. ..
  60. MRI of Brain Function and Receptors in Cocaine Addiction
    Craig Ferris; Fiscal Year: 2005
    ..With this repeated 'in vivo autoradiography,' it is possible to correlate changes in cocaine associated brain activity with discrete changes in NT binding in the mesocorticolimbic system. ..
  61. ADOLESCENT STRESS AND NEURAL PLASTICITY
    Craig Ferris; Fiscal Year: 2004
    ..This work will help understand the effects of stress in adolescence and the ability of the brain to recover from insult at this potentially vulnerable period of development. ..
  62. Developmental Differences in Brain Androgen Synthesis
    Sarah London; Fiscal Year: 2004
    ..They will also indicate potential regulatory mechanisms for androgen synthesis in other species, including humans. ..
  63. UCP5-- Balancing Metabolism and Oxidation in Aging Brain
    LAURA DUGAN; Fiscal Year: 2004
    ....
  64. Ethanol: Protracted Changes in Brain Glucose Metabolism
    Conan Kornetsky; Fiscal Year: 2004
    ....
  65. NEURAL MODULATION OF CENTRAL TASTE PROCESSING
    ROBERT LUNDY; Fiscal Year: 2009
    ....
  66. Emotion, Pain and Pain Control Circuits
    KATHRYN COMMONS; Fiscal Year: 2003
    ..The results of these studies will-yield insight into how distinct modes of stressful stimuli impact SP neurotransmission within neural circuits that coordinate defensive coping strategies. ..
  67. Centrifugal Control of Pontine Gustatory Processing
    ROBERT LUNDY; Fiscal Year: 2004
    ..If not, as we predict, are the same neurons influenced by centrifugal input from the CeA, LH, and GC, and in the same way? ..
  68. NEUROPATHOLOGY AND PATHOGENESIS OF HUNTINGTON' DISEASE
    Anton Reiner; Fiscal Year: 2004
    ....