paraventricular hypothalamic nucleus

Summary

Summary: Nucleus in the anterior part of the hypothalamus.

Top Publications

  1. pmc Deconstruction of a neural circuit for hunger
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive Ashburn, Virginia 20147, USA
    Nature 488:172-7. 2012
  2. ncbi Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice
    Evan Elliott
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Nat Neurosci 13:1351-3. 2010
  3. pmc Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure
    Xian bing Gan
    Department of Physiology, Nanjing Medical University, Nanjing, China
    PLoS ONE 6:e25784. 2011
  4. pmc Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 150:3118-27. 2009
  5. ncbi Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    James E Blevins
    VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004
  6. pmc Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing
    Jonathan Biag
    Laboratory of Neuroimaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7334, USA
    J Comp Neurol 520:6-33. 2012
  7. ncbi A role for the paraventricular nucleus of the hypothalamus in the autonomic control of heart and kidney
    J H Coote
    Neuroscience, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Exp Physiol 90:169-73. 2005
  8. pmc The geometry of leptin action in the brain: more complicated than a simple ARC
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 9:117-23. 2009
  9. pmc An obligate role of oxytocin neurons in diet induced energy expenditure
    Zhaofei Wu
    Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
    PLoS ONE 7:e45167. 2012
  10. pmc Paraventricular hypothalamic nucleus: axonal projections to the brainstem
    Joel C Geerling
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 518:1460-99. 2010

Detail Information

Publications347 found, 100 shown here

  1. pmc Deconstruction of a neural circuit for hunger
    Deniz Atasoy
    Janelia Farm Research Campus, Howard Hughes Medical Institute, 19700 Helix Drive Ashburn, Virginia 20147, USA
    Nature 488:172-7. 2012
    ..These experiments reveal a new neural circuit that regulates hunger state and pathways associated with overeating disorders...
  2. ncbi Resilience to social stress coincides with functional DNA methylation of the Crf gene in adult mice
    Evan Elliott
    Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel
    Nat Neurosci 13:1351-3. 2010
    ..Demethylation was observed only in the subset of defeated mice that displayed social avoidance and site-specific knockdown of Crf attenuated the stress-induced social avoidance...
  3. pmc Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure
    Xian bing Gan
    Department of Physiology, Nanjing Medical University, Nanjing, China
    PLoS ONE 6:e25784. 2011
    ..This study was designed to determine whether it is true in intact (INT) rats with CHF and to determine the effects of cardiac and baroreceptor afferents on the CSAR and sympathetic activity in CHF...
  4. pmc Elevated glucocorticoid levels are responsible for induction of tyrosine hydroxylase mRNA expression, phosphorylation, and enzyme activity in the nucleus of the solitary tract during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, 30100 Murcia, Spain
    Endocrinology 150:3118-27. 2009
    ....
  5. ncbi Evidence that paraventricular nucleus oxytocin neurons link hypothalamic leptin action to caudal brain stem nuclei controlling meal size
    James E Blevins
    VA Puget Sound Health Care System, Research Service 151 1660 S Columbian Wy, Seattle, WA 98108, USA
    Am J Physiol Regul Integr Comp Physiol 287:R87-96. 2004
    ....
  6. pmc Cyto- and chemoarchitecture of the hypothalamic paraventricular nucleus in the C57BL/6J male mouse: a study of immunostaining and multiple fluorescent tract tracing
    Jonathan Biag
    Laboratory of Neuroimaging, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7334, USA
    J Comp Neurol 520:6-33. 2012
    ..We discuss these data in relation to what is known about PVH function and provide the work as a resource for further studies of the neuronal architecture and function of the mouse PVH...
  7. ncbi A role for the paraventricular nucleus of the hypothalamus in the autonomic control of heart and kidney
    J H Coote
    Neuroscience, The Medical School, University of Birmingham, Birmingham, B15 2TT, UK
    Exp Physiol 90:169-73. 2005
    ..How this might give rise to increased sympathetic activity associated with heart failure is briefly discussed...
  8. pmc The geometry of leptin action in the brain: more complicated than a simple ARC
    Martin G Myers
    Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Cell Metab 9:117-23. 2009
    ....
  9. pmc An obligate role of oxytocin neurons in diet induced energy expenditure
    Zhaofei Wu
    Brown Foundation Institute of Molecular Medicine, University of Texas Medical School at Houston, Houston, Texas, USA
    PLoS ONE 7:e45167. 2012
    ..Thus, our study suggests that oxytocin neurons are required to resist the obesity associated with a high fat diet; but their role in feeding is permissive and can be compensated for by redundant pathways...
  10. pmc Paraventricular hypothalamic nucleus: axonal projections to the brainstem
    Joel C Geerling
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 518:1460-99. 2010
    The paraventricular hypothalamic nucleus (PVH) contains many neurons that innervate the brainstem, but information regarding their target sites remains incomplete...
  11. pmc Multinodal regulation of the arcuate/paraventricular nucleus circuit by leptin
    Masoud Ghamari-Langroudi
    Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232 0615, USA
    Proc Natl Acad Sci U S A 108:355-60. 2011
    ..Thus, leptin acts multinodally on arcuate nucleus/PVN circuits to regulate energy homeostasis, with prominent mechanisms involving direct control of both membrane conductances and gene expression in the MC4R PVN neuron...
  12. ncbi Divergence of melanocortin pathways in the control of food intake and energy expenditure
    Nina Balthasar
    Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, Massachusetts 02215, USA
    Cell 123:493-505. 2005
    ..Disassociation of food intake and energy expenditure reveals unexpected divergence in melanocortin pathways controlling energy balance...
  13. pmc Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1
    J L Michaud
    Department of Embryology, Carnegie Institution of Washington, Baltimore, Maryland 21210 USA
    Genes Dev 12:3264-75. 1998
    ..Our results strongly indicate that SIM1 functions upstream to maintain Brn2 expression, which in turn directs the terminal differentiation of specific neuroendocrine lineages within the PVN/SON...
  14. ncbi Comparison of the spatial distribution of seven types of neuroendocrine neurons in the rat paraventricular nucleus: toward a global 3D model
    Donna M Simmons
    Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
    J Comp Neurol 516:423-41. 2009
    ....
  15. ncbi Paraventricular nucleus is involved in the central pathway of cardiac sympathetic afferent reflex in rats
    Ming Kui Zhong
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Exp Physiol 93:746-53. 2008
    ..These results indicate that inhibition or lesion of the PVN abolishes the CSAR, but excitation of the neurons in the PVN enhances the CSAR, suggesting that the PVN is an important component of the central neurocircuitry of the CSAR...
  16. ncbi Superoxide anions in the paraventricular nucleus mediate the enhanced cardiac sympathetic afferent reflex and sympathetic activity in renovascular hypertensive rats
    Ying Han
    Dept of Physiology, Nanjing Medical Univ, Nanjing 210029, China
    J Appl Physiol (1985) 110:646-52. 2011
    ..These results indicate that superoxide anions in the PVN mediate the CSAR and the effects of ANG II in the PVN. Increased superoxide anions in the PVN contribute to the enhanced CSAR and sympathetic activity in renovascular hypertension...
  17. ncbi How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli
    S Rivest
    Laboratory of Molecular Endocrinology, CHUL Research Center, Department of Anatomy, Quebec, Canada
    Proc Soc Exp Biol Med 223:22-38. 2000
    ..The induction of fever, the hypothalamic-pituitary adrenal (HPA) axis, and other autonomic functions are among the physiological outcomes necessary for the protection of the mammalian organism in the presence of foreign material...
  18. ncbi Developmental switch in neuropeptide Y and melanocortin effects in the paraventricular nucleus of the hypothalamus
    Igor Melnick
    Department of Pharmacology, University of Alberta, Edmonton AB, T6G 2H7, Canada
    Neuron 56:1103-15. 2007
    ..This primarily NPYergic regulation in the neonates likely promotes the positive energy balance necessary for growth, while the developmental switch correlates with maturation of homeostatic regulation of energy balance...
  19. ncbi Intrahypothalamic estradiol modulates hypothalamus-pituitary-adrenal-axis activity in female rats
    J Liu
    Chinese Academy of Science Key Laboratory of Brain Function and Diseases, School of Life Sciences, University of Science and Technology of China, Jinzhai Road 96, Hefei 230026, Anhui, People s Republic of China
    Endocrinology 153:3337-44. 2012
    ..In the basal condition, the stimulation is mediated by ERα-sensitive neurons, whereas during stress, it is mediated by both ERα and ERβ...
  20. pmc Hydrogen sulfide in paraventricular nucleus enhances sympathetic activity and cardiac sympathetic afferent reflex in chronic heart failure rats
    Xian bing Gan
    Key Laboratory of Cardiovascular Disease and Molecular Intervention, Department of Physiology, Nanjing Medical University, Nanjing, China
    PLoS ONE 7:e50102. 2012
    ..This study was designed to determine the roles of H(2)S in the paraventricular nucleus (PVN) in modulating sympathetic activity and cardiac sympathetic afferent reflex (CSAR) in chronic heart failure (CHF)...
  21. pmc Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval
    Eva M Fekete
    Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA
    Neuropsychopharmacology 32:1052-68. 2007
    ..The results implicate the VMN and PVN of the hypothalamus as sites for Ucn 3-CRF(2) control of food intake...
  22. pmc Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone
    Aniko Korosi
    Anatomy Neurobiology and Pediatrics, University of California Irvine, Irvine, California 92697, USA
    J Neurosci 30:703-13. 2010
    ....
  23. ncbi Neuromedin U receptor-2 mRNA and HCN channels mRNA expression in NMU-sensitive neurons in rat hypothalamic paraventricular nucleus
    De lai Qiu
    Department of Physiology, Miyazaki Medical College, University of Miyazaki, 5200 Kihara, Kiyotake cho, Miyazaki gun, Miyazaki 889 1692, Japan
    Neurosci Lett 374:69-72. 2005
    ..These results suggest that NMU modulates the function of the PVN putative parvocellular neurons and is involved in the regulation of OTergic and VPergic neurons by enhanced HCN ion channels activity via NMU-receptor 2...
  24. pmc Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue
    C J Madden
    Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Am J Physiol Regul Integr Comp Physiol 296:R831-43. 2009
    ..These results demonstrate that disinhibition of neurons in the PVH inhibits BAT SNA likely via activation of a GABAergic input to BAT sympathetic premotor neurons in the RPa...
  25. pmc CRF₂ mediates the increased noradrenergic activity in the hypothalamic paraventricular nucleus and the negative state of morphine withdrawal in rats
    Javier Navarro-Zaragoza
    Group of Cellular and Molecular Pharmacology, University School of Medicine, Murcia, Spain
    Br J Pharmacol 162:851-62. 2011
    ....
  26. ncbi Activation of stress-related hypothalamic neuropeptide gene expression during morphine withdrawal
    Cristina Nunez
    Department of Pharmacology, University of Murcia, Murcia, Spain
    J Neurochem 101:1060-71. 2007
    ..These activations however were not associated with induction of CRH or AVP hnRNAs...
  27. pmc Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure
    Yu Ming Kang
    Univ of Iowa College of Medicine, Iowa City, IA 52242, USA
    Am J Physiol Heart Circ Physiol 295:H227-36. 2008
    ..These findings suggest that the increase in brain proinflammatory cytokines observed in rats with ischemia-induced HF is functionally significant, contributing to neurohumoral excitation by activating brain RAS and the HPA axis...
  28. ncbi Age and time of day influences on the expression of transforming growth factor-beta and phosphorylated SMAD3 in the mouse suprachiasmatic and paraventricular nuclei
    Amy L Beynon
    Neuroscience and Molecular Psychiatry, Institute of Life Science, School of Medicine, Swansea University, Swansea, UK
    Neuroimmunomodulation 16:392-9. 2009
    ....
  29. ncbi Nitric oxide and homeostatic control: an intercellular signalling molecule contributing to autonomic and neuroendocrine integration?
    Javier E Stern
    Department of Pharmacology and Toxicology, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    Prog Biophys Mol Biol 84:197-215. 2004
    ..We propose that this dynamic NO signaling mechanisms may constitute a neuroanatomical and functional substrate underlying the ability of the SON and PVN to coordinate complex neuroendocrine and autonomic output patterns...
  30. ncbi Blunted fasting-induced hypothalamic activation and refeeding hyperphagia in late-onset obesity
    Csilla Becskei
    Institute of Veterinary Physiology and Zurich Centre of Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Neuroendocrinology 90:371-82. 2009
    ..A similar impact of hyperinsulinemia and hyperleptinemia in LOO mice is also likely although under the current experimental conditions responsiveness to some effects of these hormones appeared to be reduced...
  31. ncbi Regulation of serine (Ser)-31 and Ser40 tyrosine hydroxylase phosphorylation during morphine withdrawal in the hypothalamic paraventricular nucleus and nucleus tractus solitarius-A2 cell group: role of ERK1/2
    Cristina Nunez
    Department of Pharmacology, University School of Medicine, Campus de Espinardo, Murcia, Spain
    Endocrinology 148:5780-93. 2007
    ..These results suggest that morphine withdrawal increases noradrenaline turnover in the PVN, at least in part, via ERK(1/2)-dependent phosphorylation of TH at Ser31...
  32. ncbi Impaired thermoregulatory ability of oxytocin-deficient mice during cold-exposure
    Yoshiyuki Kasahara
    Laboratory of Molecular Biology, Department of Molecular and Cell Biology, Graduate School of Agricultural Science, Tohoku University, Sendai, Miyagi, Japan
    Biosci Biotechnol Biochem 71:3122-6. 2007
    ..These results suggest that the central oxytocin neurons constitute part of the thermoregulatory system involved in maintaining body temperature in cold environments...
  33. ncbi Chronic stress-induced neurotransmitter plasticity in the PVN
    Jonathan N Flak
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Comp Neurol 517:156-65. 2009
    ..These changes could lead to an enhanced capacity for excitation in these neurons, contributing to chronic stress-induced hyperreactivity of stress effector systems in the brain...
  34. ncbi Expression of alpha(1b) adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone
    H E Day
    Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    J Neurosci 19:10098-106. 1999
    ..Because activation of the alpha(1B) adrenoceptor is predominantly excitatory within the brain, we predict that this receptor plays an important role in facilitation of the HPA axis response...
  35. ncbi The androgen 5alpha-dihydrotestosterone and its metabolite 5alpha-androstan-3beta, 17beta-diol inhibit the hypothalamo-pituitary-adrenal response to stress by acting through estrogen receptor beta-expressing neurons in the hypothalamus
    Trent D Lund
    Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 26:1448-56. 2006
    ..Together, these studies indicate that the inhibitory effects of DHT on HPA axis activity may be in part mediated via its conversion to 3beta-diol and subsequent binding to ERbeta...
  36. ncbi Distribution of galanin-like peptide in the rat brain
    Y Takatsu
    Discovery Research Laboratories I, Pharmaceutical Discovery Research Division, Takeda Chemical Industries Co, Ltd, Wadai 10, Tsukuba, Ibaraki 300-4293, Japan
    Endocrinology 142:1626-34. 2001
    ..Dense staining of GALP-containing fibers was found in the anterior parvicellular part of the paraventricular hypothalamic nucleus, in the ventral part of the lateral septal nucleus, and in the bed nucleus of the stria terminalis...
  37. pmc Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity
    Jacob C Garza
    Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78229, USA
    J Endocrinol 197:471-82. 2008
    ..Our results provide evidence that AAV-mediated silencing of MC4R on PVN neurons promotes hyperphagia and obesity in response to the dietary challenge in the adult animal...
  38. pmc Enhanced angiotensin-mediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure
    Hong Zheng
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5850, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1364-74. 2009
    ....
  39. ncbi Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism
    Shi Di
    Division of Neurobiology, Department of Cell and Molecular Biology, Tulane University, New Orleans, Louisiana 70118 5698, USA
    J Neurosci 23:4850-7. 2003
    ....
  40. pmc Angiotensin II-induced hypertension is modulated by nuclear factor-κBin the paraventricular nucleus
    Jeffrey P Cardinale
    Comparative Biomedical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
    Hypertension 59:113-21. 2012
    ..This demonstrates the important role that transcription factor NFκB plays within the PVN in modulating and perpetuating the hypertensive response via renin-angiotensin system modulation...
  41. pmc The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress
    Greti Aguilera
    Section on Endocrine Physiology, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, NIH, Bethesda, MD, USA
    Prog Brain Res 170:29-39. 2008
    ....
  42. ncbi Reactive oxygen species in the paraventricular nucleus mediate the cardiac sympathetic afferent reflex in chronic heart failure rats
    Ying Han
    Department of Physiology, Nanjing Medical University, Nanjing 210029, China
    Eur J Heart Fail 9:967-73. 2007
    ..These results indicate that ROS in the PVN mediates the CSAR and the effect of angiotensin II in the PVN on the CSAR in both CHF and sham-operated rats. Increased ROS in the PVN are involved in the enhanced CSAR in CHF...
  43. ncbi NPY and cohorts in regulating appetite, obesity and metabolic syndrome: beneficial effects of gene therapy
    S P Kalra
    Department of Neuroscience, University of Florida, McKnight Brain Institute, PO Box 100244, Gainesville, FL 32610, USA
    Neuropeptides 38:201-11. 2004
    ..e. bring under homeostatic control, NPYergic signaling and suppress the age-related and dietary obesity for extended periods and thus shows promise as a newer treatment modality to curb the pandemic of obesity and metabolic syndrome...
  44. ncbi Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions
    R A L Dampney
    Department of Physiology and Institute for Biomedical Research, The University of Sydney, Sydney, New South Wales, Australia
    Clin Exp Pharmacol Physiol 32:419-25. 2005
    ..However, little is known about the cellular mechanisms that could cause such resetting...
  45. ncbi ANG II in the paraventricular nucleus potentiates the cardiac sympathetic afferent reflex in rats with heart failure
    Guo Qing Zhu
    Department of Physiology, Nanjing Medical University, Nanjing 210029, Peoples Republic of China
    J Appl Physiol 97:1746-54. 2004
    ....
  46. ncbi c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats
    Ying Han
    Department of Physiology, Nanjing Medical University, Nanjing, China
    Pflugers Arch 461:437-46. 2011
    ....
  47. pmc Electrophysiological and morphological properties of pre-autonomic neurones in the rat hypothalamic paraventricular nucleus
    J E Stern
    Department of Pharmacology and Toxicology, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA
    J Physiol 537:161-77. 2001
    ....
  48. ncbi Angiotensin-mediated increase in renal sympathetic nerve discharge within the PVN: role of nitric oxide
    Yi Fan Li
    Division of Basic Biomedical Science, College of Medicine, University of South Dakota, Vermillion, South Dakota, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1035-43. 2006
    ..This negative-feedback mechanism within the PVN may play an important role in maintaining the overall balance and tone of sympathetic outflow...
  49. pmc A hypomorphic vasopressin allele prevents anxiety-related behavior
    Mirjam Bunck
    Max Planck Institute of Psychiatry, Munich, Germany
    PLoS ONE 4:e5129. 2009
    ....
  50. pmc Brain nuclear factor-kappa B activation contributes to neurohumoral excitation in angiotensin II-induced hypertension
    Yu Ming Kang
    Shantou University Medical College, Shantou 515041, People s Republic of China
    Cardiovasc Res 82:503-12. 2009
    ..In this study, we determined whether nuclear factor-kappa B (NF-kappaB) activation in the hypothalamic paraventricular nucleus (PVN) increases oxidative stress and contributes to the ANG II-induced hypertensive response...
  51. ncbi Impaired repression at a vasopressin promoter polymorphism underlies overexpression of vasopressin in a rat model of trait anxiety
    Chris Murgatroyd
    Max Planck Institute of Psychiatry, 80804 Munich, Germany
    J Neurosci 24:7762-70. 2004
    ..Taken together, our results demonstrate a role for an AVP gene polymorphism and CBF-A in elevated AVP expression in the PVN of HAB rats likely to contribute to their behavioral and neuroendocrine phenotype...
  52. ncbi Central vasopressin and oxytocin release: regulation of complex social behaviours
    Alexa H Veenema
    Department of Behavioural Neuroendocrinology, Institute of Zoology, University of Regensburg, Regensburg, Germany
    Prog Brain Res 170:261-76. 2008
    ....
  53. ncbi Adrenal insufficiency and colonic inflammation after a novel chronic psycho-social stress paradigm in mice: implications and mechanisms
    S O Reber
    Department of Zoology, University of Regensburg, 93040 Regensburg, Germany
    Endocrinology 148:670-82. 2007
    ....
  54. ncbi Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding
    Daisuke Kohno
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University, School of Medicine, Tochigi 329 0498, Japan
    Endocrinology 149:1295-301. 2008
    ..Feeding-activated nesfatin-1 neurons in the PVN and SON could play a role in the postprandial regulation of feeding behavior and energy homeostasis...
  55. ncbi Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus
    Teresa M Reyes
    Laboratory of Neuronal Structure and Function, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:5607-16. 2003
    The paraventricular hypothalamic nucleus (PVH) is a key site for integrating neuroendocrine, autonomic, and behavioral adjustments to diverse homeostatic challenges, including "physiological" (e.g...
  56. ncbi Brain oxytocin correlates with maternal aggression: link to anxiety
    Oliver J Bosch
    Institute of Zoology, University of Regensburg, 93040 Regensburg, Germany
    J Neurosci 25:6807-15. 2005
    ..Therefore, differences in intracerebral release patterns of oxytocin, rather than differences at the level of oxytocin receptors, are critical for the regulation of maternal aggressive behavior...
  57. ncbi Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness
    James P Herman
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Front Neuroendocrinol 24:151-80. 2003
    ..Imbalances among these limbic pathways and homeostatic sensors are likely to underlie hypothalamo-pituitary-adrenocortical dysfunction associated with numerous disease processes...
  58. pmc Novel leptin-regulated genes revealed by transcriptional profiling of the hypothalamic paraventricular nucleus
    Yi Chun Loraine Tung
    University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke s Hospital, Cambridge CB2 0QQ, United Kingdom
    J Neurosci 28:12419-26. 2008
    ..Thus, in addition to its effects on the expression of a broad range of neuropeptides, leptin may also exert more general influences on synaptic function in, and the bioenergetic state of, the PVN...
  59. ncbi Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus
    Annegret Blume
    Department of Behavioural and Molecular Neuroendocrinology, Institute of Zoology, University of Regensburg, Germany
    Eur J Neurosci 27:1947-56. 2008
    ..Thus, OTR agonism or activation of the ERK1/2 cascade, specifically within the hypothalamus, may provide therapeutically relevant mechanisms...
  60. ncbi Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus
    Luisa M Seoane
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
    Endocrinology 144:544-51. 2003
    ..This study furthers our understanding of the molecular basis and mechanisms involved in the effect of ghrelin on food intake and GH secretion...
  61. ncbi A synaptocentric view of the neuroendocrine response to stress
    Jaclyn I Wamsteeker
    Hotchkiss Brain Institute and Department of Physiology and Pharmacology, University of Calgary, 3330 Hospital Dr NW, Calgary, AL, T2N 4N1 Canada
    Eur J Neurosci 32:2011-21. 2010
    ..Within this context, we examine possible synaptic correlates that allow this neuroendocrine system to learn and adapt following stress challenges...
  62. pmc Imbalanced K+ and Ca2+ subthreshold interactions contribute to increased hypothalamic presympathetic neuronal excitability in hypertensive rats
    P M Sonner
    Department of Physiology, Medical College of Georgia, Augusta, GA 30912, USA
    J Physiol 589:667-83. 2011
    ..Knowledge of how these opposing ion channels interact in normal and disease states increases our understanding of underlying brain mechanisms contributing to the high blood pressure condition...
  63. pmc The anteroventral bed nucleus of the stria terminalis differentially regulates hypothalamic-pituitary-adrenocortical axis responses to acute and chronic stress
    Dennis C Choi
    Neuroscience Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Endocrinology 149:818-26. 2008
    ....
  64. pmc Reduction in synaptic GABA release contributes to target-selective elevation of PVN neuronal activity in rats with myocardial infarction
    Tae Hee Han
    Laboratories of Veterinary Pharmacology, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea
    Am J Physiol Regul Integr Comp Physiol 299:R129-39. 2010
    ..These results provide evidence for a novel target-selective synaptic plasticity in the PVN that is associated with the sympathetic hyperactivity commonly seen in heart failure...
  65. ncbi Peptidomic identification and biological validation of neuroendocrine regulatory peptide-1 and -2
    Hideki Yamaguchi
    Division of Neurology, Respirology, Endocrinology, and Metabolism, Department of Internal Medicine, Miyazaki Medical College, University of Miyazaki, Kihara, Kiyotake, Miyazaki 889 1692, Japan
    J Biol Chem 282:26354-60. 2007
    ..These findings suggest that NERPs are novel modulators in body fluid homeostasis...
  66. ncbi SOD1 overexpression in paraventricular nucleus improves post-infarct myocardial remodeling and ventricular function
    Juan Gao
    Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu, 210029, China
    Pflugers Arch 463:297-307. 2012
    ..These results indicate that the SOD1 overexpression in the PVN attenuates the excessive sympathetic activation, myocardial remodeling, cardiomyocyte apoptosis and ventricular dysfunction in MI rats...
  67. ncbi Role of GABA and NO in the paraventricular nucleus-mediated reflex inhibition of renal sympathetic nerve activity following stimulation of right atrial receptors in the rat
    Zhuo Yang
    Department of Physiology, Division of Medical Sciences, School of Medicine, The University of Birmingham, UK
    Exp Physiol 88:335-42. 2003
    ..The effect of subsequent balloon inflation on RSNA was not significantly reduced. It was concluded that atrial receptor activation causes an inhibition of RSNA at the PVN and that this effect is mediated by GABA...
  68. ncbi Forced swimming stimulates the expression of vasopressin and oxytocin in magnocellular neurons of the rat hypothalamic paraventricular nucleus
    C T Wotjak
    , Kraepelinstr. 2, , Germany
    Eur J Neurosci 13:2273-81. 2001
    ..Within the SON, however, mRNA levels are poor indicators of the secretory activity of magnocellular neurons during stress...
  69. ncbi Role of signal transducer and activator of transcription 3 in regulation of hypothalamic trh gene expression by leptin
    Lihong Huo
    Division of Endocrinology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Endocrinology 145:2516-23. 2004
    ....
  70. ncbi The suprachiasmatic nucleus balances sympathetic and parasympathetic output to peripheral organs through separate preautonomic neurons
    Ruud M Buijs
    Netherlands Institute for Brain Research, 1105 AZ Amsterdam, The Netherlands
    J Comp Neurol 464:36-48. 2003
    ..These separate preautonomic SCN neurons provide the anatomical basis for the circadian-driven regulation of the parasympathetic and sympathetic autonomic output...
  71. ncbi VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus
    De Pei Li
    Department of Anesthesiology, H187, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    J Neurophysiol 92:1807-16. 2004
    ..Presynaptic VR(1) receptors and endogenous capsaicin-like substances in the PVN may represent a previously unidentified mechanism in hypothalamic regulation of the autonomic nervous system...
  72. ncbi Centrally administered orexin-A activates corticotropin-releasing factor-containing neurons in the hypothalamic paraventricular nucleus and central amygdaloid nucleus of rats: possible involvement of central orexins on stress-activated central CRF neurons
    Fumihiko Sakamoto
    Department of Occupational Health, Matsushita Science Center of Industrial Hygiene, 7 6 Tonoshima cho, Kadoma 571 0045, Japan
    Regul Pept 118:183-91. 2004
    ..These results suggest that orexins in the central nervous system may be involved in the activation of central CRF neurons induced by stress...
  73. ncbi Postnatal glucocorticoid excess due to pituitary glucocorticoid receptor deficiency: differential short- and long-term consequences
    Mathias V Schmidt
    Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 150:2709-16. 2009
    ..Postnatal glucocorticoid excess results in an altered stress-coping behavior in adult animals, with no effects on anxiety like behavior or cognition...
  74. pmc Diminished A-type potassium current and altered firing properties in presympathetic PVN neurones in renovascular hypertensive rats
    Patrick M Sonner
    Department of Psychiatry, University of Cincinnati, Genome Research Institute, 2170 E Galbraith Rd, Cincinnati, OH 45237, USA
    J Physiol 586:1605-22. 2008
    ..Altogether, our results indicate that diminished I(A) availability constitutes a contributing mechanism underlying aberrant central neuronal function in renovascular hypertension...
  75. ncbi Aberrant stress hormone receptor balance in the human prefrontal cortex and hypothalamic paraventricular nucleus of depressed patients
    Xin Rui Qi
    Netherlands Institute for Neuroscience, an institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands
    Psychoneuroendocrinology 38:863-70. 2013
    ..These changes may contribute to HPA-axis hyperactivity and hence to depression etiology...
  76. pmc The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin
    Silvana Gaetani
    Department of Physiology and Pharmacology V Erspamer, Sapienza University of Rome, 00185 Rome, Italy
    J Neurosci 30:8096-101. 2010
    ..The results suggest that OEA suppresses feeding by activating central oxytocin transmission...
  77. pmc Baclofen inhibits guinea pig magnocellular neurones via activation of an inwardly rectifying K+ conductance
    Robert M Slugg
    Department of Physiology and Pharmacology, L334, Oregon Health Sciences University, 3181 Sam Jackson Park Road, Portland, OR 97201, USA
    J Physiol 551:295-308. 2003
    ..Therefore, GABAB receptors are coupled to inwardly rectifying K+ channels in SON and PVN magnocellular neurones and may play a prominent role in modulating phasic bursting activity in guinea pig vasopressin neurones...
  78. pmc In vivo discharge properties of hypothalamic paraventricular nucleus neurons with axonal projections to the rostral ventrolateral medulla
    Qing Hui Chen
    Dept of Physiology, University of Texas Health Science Center, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    J Neurophysiol 103:4-15. 2010
    ..These results indicate that PVN-RVLM and PVN-RVLM/IML neurons are both capable of contributing to basal sympathetic activity and its baroreflex modulation...
  79. ncbi Activation of a G protein-coupled inwardly rectifying K+ current and suppression of Ih contribute to dexmedetomidine-induced inhibition of rat hypothalamic paraventricular nucleus neurons
    Tetsuro Shirasaka
    Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Miyazaki, Japan
    Anesthesiology 107:605-15. 2007
    ..The purpose of this study was to examine the effects of dexmedetomidine on the PVN neuron, which is involved in the arginine vasopressin release and autonomic regulation...
  80. ncbi Neurochemistry of the paraventricular nucleus of the hypothalamus: implications for cardiovascular regulation
    S Pyner
    School of Biological and Biomedical Sciences, Durham University, South Road, Durham, DH1 3LE, UK
    J Chem Neuroanat 38:197-208. 2009
    ..Dopaminergic effects on the cardiovascular system include inhibitory or excitatory actions attributed to a direct PVN influence or via interneuronal connections to sympathetic preganglionic neurones...
  81. ncbi Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway
    Yuko Maejima
    Division of Integrative Physiology, Department of Physiology, Jichi Medical University School of Medicine, Shimotsuke, Tochigi 329 0498, Japan
    Cell Metab 10:355-65. 2009
    ..The present results reveal the nesfatin-1-operative oxytocinergic signaling in the PVN that triggers leptin-independent melanocortin-mediated anorexia...
  82. ncbi Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone
    Ana Quênia Gomes da Silva
    Departamento de Fisiologia e Biofisica, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil
    Hypertension 46:341-8. 2005
    In this study, we tested the hypothesis that angiotensin-(1-7) [Ang-(1-7)] acting in the neurons of paraventricular hypothalamic nucleus (PVN) contributes to the maintenance of sympathetic activity and blood pressure...
  83. ncbi Corticotrophin-releasing factor inhibits neuromedin U mRNA expressing neuron in the rat hypothalamic paraventricular nucleus in vitro
    Chun Ping Chu
    Cellular Function Research Center, Yanbian University, 977, Gongyuan Road, Yanji City, Jilin Province 133002, China
    Neurosci Lett 511:79-83. 2012
    ..6±7.8%. These findings suggest that CRF decreases neuronal excitability and diminishes T-type Ca(2+) currents in a population of rat PVN NMU phenotype neurons in vitro...
  84. ncbi Circadian rhythms in isolated brain regions
    Michikazu Abe
    National Science Foundation Center for Biological Timing and Department of Biology, University of Virginia, Charlottesville, Virginia 22904, USA
    J Neurosci 22:350-6. 2002
    ..The phasing of these oscillators to one another may play a critical role in coordinating brain activity and its adjustment to changes in the light cycle...
  85. ncbi Neurochemical properties of the prolactin releasing peptide (PrRP) receptor expressing neurons: evidence for a role of PrRP as a regulator of stress and nociception
    Steven H S Lin
    Department of Pharmacology, College of Medicine, Med Surge II, Room 366, University of California, Irvine, Irvine, CA 92697, USA
    Brain Res 952:15-30. 2002
    ..We also suggest that PrRP may modulate nociception by virtue of its receptor's co-expression with ENK in PB. Our results provide a theoretical framework by which future studies examining the role of PrRP in brain could be elucidated...
  86. ncbi The role of intracerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone neurons in the hypothalamic paraventricular nucleus
    Mario Perello
    Division of Endocrinology, Department of Medicine, Brown Medical School Rhode Island Hospital, 55 Claverick Street, 4th Floor, Room 430, Providence, 02903, USA
    Endocrinology 147:3296-306. 2006
    ..These findings are critical to a better understanding of leptin-mediated actions in energy expenditure...
  87. ncbi Opposite regulation of body temperature by cholinergic input to the paraventricular nucleus and supraoptic nucleus in rats
    A Takahashi
    Department of Neuropsychopharmacology Tsumura, Gunma University School of Medicine, Maebashi, 371 8511, Gunma, Japan
    Brain Res 909:102-11. 2001
    ..The same neuronal pathway including LC and NTS may participate in an advance both in hypothermia and in hyperthermia...
  88. ncbi Expression of ionotropic glutamate receptor subunit mRNAs in the hypothalamic paraventricular nucleus of the rat
    J P Herman
    Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0559, USA
    J Comp Neurol 422:352-62. 2000
    ..Localization of all species in the perinuclear PVN suggests that glutamate input to the immediate region of the PVN may modulate its function, perhaps by communication with local gamma-aminobutyric acid neurons...
  89. ncbi Glutamate mediates an excitatory influence of the paraventricular hypothalamic nucleus on the dorsal motor nucleus of the vagus
    Xueguo Zhang
    Laboratory of Neurogastroenterology Research, Division of Gastroenterology, Henry Ford Health System, Detroit, Michigan 48202, USA
    J Neurophysiol 88:49-63. 2002
    ..The NMDA receptor plays only a minor role in the excitatory effect...
  90. ncbi Activation of the central nervous system in obese Zucker rats during food deprivation
    E Timofeeva
    , , , Canada, G1K 7P4
    J Comp Neurol 441:71-89. 2001
    ..the retrograde tracer cholera toxin B subunit was injected in the parvocellular division of the paraventricular hypothalamic nucleus of obese rats and colocalized with c-fos mRNA during food deprivation...
  91. ncbi Central administration of glucagon-like peptide-1 activates hypothalamic neuroendocrine neurons in the rat
    P J Larsen
    Department of Medical Anatomy, University of Copenhagen, Denmark
    Endocrinology 138:4445-55. 1997
    ..Therefore, we conclude that GLP-1 activates the hypothalamo-pituitary-adrenocortical axis primarily through stimulation of CRH neurons, and this activation may also be responsible for the inhibition of feeding behavior...
  92. pmc Forebrain origins of glutamatergic innervation to the rat paraventricular nucleus of the hypothalamus: differential inputs to the anterior versus posterior subregions
    Yvonne M Ulrich-Lai
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Comp Neurol 519:1301-19. 2011
    ..The results suggest that PVN subregions are influenced by varying amounts and sources of forebrain glutamatergic regulation, consistent with functional differentiation of glutamate projections...
  93. ncbi Oxytocin injected into the ventral tegmental area induces penile erection and increases extracellular dopamine in the nucleus accumbens and paraventricular nucleus of the hypothalamus of male rats
    Maria Rosaria Melis
    Bernard B Brodie Department of Neuroscience, University of Cagliari, S P Sestu Monserrato, Monserrato, Italy
    Eur J Neurosci 26:1026-35. 2007
    ....
  94. ncbi Interaction between alpha-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses
    Xin Yun Lu
    University of Michigan School of Medicine, Mental Health Research Institute, Ann Arbor, Michigan 48109, USA
    J Neurosci 23:7863-72. 2003
    ..Collectively, these results provide evidence that CRH acts as a downstream mediator of melanocortin signaling and contributes to the mechanisms by which the central melanocortin system controls feeding and neuroendocrine responses...
  95. ncbi Paraventricular nucleus of the hypothalamus and elevated sympathetic activity in heart failure: the altered inhibitory mechanisms
    Y F Li
    Department of Physiology and Biophysics, University of Nebraska Medical Center, 984575 Nebraska Medical Center, Omaha, NE 68198 4575, USA
    Acta Physiol Scand 177:17-26. 2003
    ..In this paper we review some of our studies, with particular emphasis on examining the role of the paraventricular nucleus (PVN) in the exaggerated sympathetic outflow commonly observed in HF...
  96. ncbi Sympathoexcitation by PVN-injected bicuculline requires activation of excitatory amino acid receptors
    Qing Hui Chen
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Tex 78229 3900, USA
    Hypertension 42:725-31. 2003
    ..These data indicate that cardiovascular and renal sympathetic responses to acute GABA-A receptor blockade in the PVN require local actions of EAAs at both NMDA and non-NMDA receptors...
  97. pmc Arginine vasopressin regulation in pre- and postpubertal male rats by the androgen metabolite 3beta-diol
    Toni R Pak
    Dept of Cell Biology, Loyola University Chicago, Stritch School of Medicine, 2160 S First Ave, Maywood, IL 60153, USA
    Am J Physiol Endocrinol Metab 296:E1409-13. 2009
    ..Interestingly, 3beta-diol-proprionate was more effective at inducing AVP expression in juveniles than in adults, suggesting that the regulation of AVP by 3beta-diol might be age dependent [corrected]...
  98. ncbi Overexpression of CART in the PVN increases food intake and weight gain in rats
    Kirsty L Smith
    Department of Investigative Medicine, Imperial College London, London, UK
    Obesity (Silver Spring) 16:2239-44. 2008
    ..To investigate the role of CART in the regulation of energy balance in the PVN, we used recombinant adeno-associated virus (rAAV) to overexpress CART in the PVN...
  99. pmc Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei
    Miyuki Tauchi
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, United States
    J Chem Neuroanat 36:144-9. 2008
    ..GLP-1 is also in position to influence oxytocin secretion and control outflow to brainstem cardiovascular relays...
  100. ncbi 5-HT(2A) receptor mediated neuronal activation within the paraventricular nucleus of the hypothalamus is desensitized following prolonged glucocorticoid treatment
    Tiffany T Y Lee
    Department of Psychology, University of British Columbia, Vancouver, BC Canada V6T1Z4
    Eur J Pharmacol 602:54-7. 2009
    ....
  101. ncbi Efferent neural projections of angiotensin receptor (AT1) expressing neurones in the hypothalamic paraventricular nucleus of the rat
    B J Oldfield
    Howard Florey Institute, The University of Melbourne, Australia
    J Neuroendocrinol 13:139-46. 2001
    ..Such neurones often contain corticotropin releasing factor. These findings highlight the role that angiotensin II and AT1 receptors in the PVN may play in the mediation of responses to stress...

Research Grants69

  1. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ....
  2. Regulation of thyroid hormone levels by central and peripheral pathways
    KRISTEN RACHEL VELLA; Fiscal Year: 2013
    ..abstract_text> ..
  3. CRF-Oxytocin Interaction in the Regulation of Stress and Affect
    Joanna Dabrowska; Fiscal Year: 2013
    ..My career objective is to conduct independent research to understand how stress and affect interact and elucidate their respective roles in the etiology of mental disorders like depression and anxiety. ..
  4. Autonomic and Antihypertensive Actions of Neuronal CGRP/RAMP1 Receptors
    Mark W Chapleau; Fiscal Year: 2013
    ..Inhibition of Ang II-mediated effects by activation of CGRP/RAMP1 receptors has widespread implications in hypertension and heart failure. ..
  5. Gonadal Steroid Receptors and the Hypothalamo-Pituitary-Adrenal Axis
    Robert J Handa; Fiscal Year: 2013
    ....
  6. Epithelial Sodium Channels in the Supraoptic Vasopressin and Oxytocin Neurons
    Ryoichi Teruyama; Fiscal Year: 2009
    ..The research in this proposal will elucidate this critical mechanism, and will increase our ability to manage hypertension. ..
  7. Neural Control of the Circulation: Sex and Hypertension
    Baojian Xue; Fiscal Year: 2013
    ....
  8. Brain interleukin-18 control of food intake and energy expenditure
    Eric P Zorrilla; Fiscal Year: 2013
    ..Such information will be key for beginning to understand the pathophysiologic and potential therapeutic relevance of central IL-18 signaling for disorders of energy homeostasis, such as obesity or cachexia. ..
  9. Role of Central Neural NFkB and ER Stress in Obesity-induced Hypertension
    COLIN NEAL YOUNG; Fiscal Year: 2013
    ..Overall, this novel and exciting proposal has the potential to lay a strong foundation for the next independent phase of the PI. ..
  10. PROTRH GENE TRANSCRIPTION AND BIOSYNTHESIS BY LEPTIN
    EDUARDO NILLNI; Fiscal Year: 2009
    ..Aim #3. We will test the hypothesis that NPY down regulates the prohormone convertases 1 and 2 (PC1/2). Aim #4. We will identify the role of the egr-1 transcription factor in regulating PC2 by leptin and NPY ..
  11. Plasticity of nTS output neurons in acute and chronic hypoxia
    DAVID DOUGLAS KLINE; Fiscal Year: 2013
    ..This will be done in a model of OSA with the expectation of understanding potential therapeutic interventions. ..
  12. Role of Oleylethanolamine in the Regulation of the HPT Axis
    Csaba Fekete; Fiscal Year: 2010
    ....
  13. Mechanisms of Programmed Gestational Hyperphagia
    MICHAEL GLENN ROSS; Fiscal Year: 2012
    ..abstract_text> ..
  14. Sex Differences in the Roles of Oxytocin and Vasopressin in Social Withdrawal
    Michael Q Steinman; Fiscal Year: 2013
    ..Together these experiments should provide insight into whether OT and AVP play a role in the development and expression of social withdrawal. ..
  15. INTERACTIONS OF LEPTIN AND CENTRAL SEROTONIN SYSTEMS
    Joel K Elmquist; Fiscal Year: 2013
    ..Results from these studies will advance our understanding of the serotoninergic circuits necessary to permit the design of effective treatment strategies for obesity and diabetes. ..
  16. MENOPAUSAL CHANGES IN HYPOTHALAMUS AND HYPERTENSION SUSCEPTIBILITY
    Teresa A Milner; Fiscal Year: 2013
    ..Moreover, they may provide the mechanistic basis for developing more effective therapeutic strategies for the management of post-menopausal increases in blood pressure. ..
  17. Central Nervous System Mechanisms of Obesity Hypertension
    Sean D Stocker; Fiscal Year: 2012
    ..This application will identify the mechanisms in the brain that link obesity and hypertension, and therefore provide a framework for the development of novel therapeutic treatments in obese individuals. ..
  18. TRH REGULATION/BIOSYNTHESIS AND PARAVENTRICULAR NUCLEUS
    RONALD MICHAEL LECHAN; Fiscal Year: 2010
    ....
  19. Cytokines and Sympathetic Activation in Heart Failure
    Robert B Felder; Fiscal Year: 2013
    ..These studies will identify currently unrecognized mechanisms driving the sympathetic nervous system in heart failure, and thus potential targets for preventive intervention. ..
  20. Identification and Validation of Human Hypothalamic Nuclei in-vivo and ex-vivo Us
    Nikolaos Makris; Fiscal Year: 2010
    ..In fact, the paraventricular hypothalamic nucleus (PVN) is enlarged in patients with major depressive disorder (MDD), in PVN neurons that are dense ..
  21. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ....
  22. Angiotensin-II, Hypothalamic Inflammation and Neurogenic Hypertension
    ANNETTE DIANE DE KLOET; Fiscal Year: 2012
    ..This is of particular relevance to public health because uncovering the mechanisms of Ang-II regulation of inflammation and cardiovascular function may lead to new strategies for the treatment and prevention of hypertension. ..
  23. CNS circuitry and receptors mediating the effects of MDMA
    Daniel E Rusyniak; Fiscal Year: 2013
    ..By identifying the brain areas and chemical receptors responsible for causing MDMA's toxicity, our research may lead to new and innovative treatments. ..
  24. Paraventricular nucleus regulatory mechanisms in stress and hypertension
    Colin Sumners; Fiscal Year: 2013
    ..Aim 2 is to determine the role of the TPOR moiety of MIF in mediating the effects of MIF within PVN neurons of SHR and normotensive rats on blood pressure regulation during acute and chronic stress. ..
  25. HYPOTHALAMIC PEPTIDES IN THE CONTROL OF ALCOHOL INTAKE
    Sarah F Leibowitz; Fiscal Year: 2013
    ..These studies of neural mechanisms in animals will provide useful information on how to predict and prevent overconsumption of alcohol and may help in designing drugs that can be used in the treatment of alcohol-use disorder. ..
  26. Circadian Clock of the Paraventricular Nucleus
    Charles J Weitz; Fiscal Year: 2012
    ..Ultimately, the work proposed here could lead to the development of new treatments for diabetes and obesity. ..
  27. Paraventricular Nucleus Signaling Mechanisms in Hypertension
    Carrie A Northcott; Fiscal Year: 2010
    ..In addition, due to the integrative nature of the PVN, these data will also provide a glimpse at the role of signaling in other physiological conditions, such as obesity. ..
  28. rAAV-GDNF to study mesolimbic control of body mass
    Ronald J Mandel; Fiscal Year: 2012
    ..A series of experiments are proposed to look at which anatomical structures contribute to this important novel effect and to determine if dopamine is required to observe GDNF-induced weight loss. ..
  29. Melanocortin system stress and HPA axis
    Xin Yun Lu; Fiscal Year: 2010
    ....
  30. Neuroendocrine Control of Glucose Metabolism
    Gregory J Morton; Fiscal Year: 2013
    ....
  31. Corticotropin-Releasing Factor Action on GI Function
    YVETTE FRANCE TACHE; Fiscal Year: 2012
    ..These studies have the potential to underpin molecular mechanisms of stress-related gut diseases leading to new treatment targeting these stress pathways. ..
  32. Brain MAP Kinases - Substrate for Sympathetic Excitation in Heart Failure
    Robert B Felder; Fiscal Year: 2013
    ..We hope these studies will identify novel targets for therapeutic intervention in systolic heart failure. ..
  33. Oxytocin and Oxytocin Neurons in the Hypothalamic Regulation of Feeding
    Bassil M Kublaoui; Fiscal Year: 2012
    ..Once generated, they will be useful to write a future R01 grant aim to effect conditional deletion Oxt in adult mice thereby eliminating developmental compensatory mechanisms. ..
  34. Role of Sim1 in Hyperphagic Obesity
    Bassil M Kublaoui; Fiscal Year: 2010
    ..We are trying understand how the brain regulates our eating behavior. We study a gene that was found to cause morbid obesity in a girl. We are using a mouse model of this gene to understand how it causes obesity. ..
  35. Sim1 Function in Feeding Regulation
    Andrew R Zinn; Fiscal Year: 2013
    ..The proposed project will delineate molecular mechanisms within the brain that regulate food intake. ..
  36. Mechanisms of nicotine and alcohol use: Focus on in utero exposure to dietary fat
    Sarah F Leibowitz; Fiscal Year: 2013
    ....
  37. Neonatal Growth and the Neurodevelopmental Origins of Hypertension
    Robert D Roghair; Fiscal Year: 2013
    ....
  38. Hypothalamic Neuronal Plasticity in Chronic Stress
    De Pei Li; Fiscal Year: 2013
    ..Also, these findings may lead to the development of novel therapies to prevent and treat psychiatric diseases such as depression. ..
  39. Oxytocin regulation of social buffering following stress
    ADAM STEVEN SMITH; Fiscal Year: 2012
    ..This research program represents several steps in examining the neurobiology mechanism underlying the social buffering effect in prairie voles. ..
  40. Adolescent alcohol exposure and altered adult HPA axis activity
    SOON O LEE; Fiscal Year: 2013
    ..This will pave the way for future experiments that investigate functional links between this adult altered endocrine activity and the increased alcohol abuse known to take place in adults exposed to alcohol when juvenile. ..
  41. Central Cardiovascular Regulation: Role of Urocortin III
    Hreday N Sapru; Fiscal Year: 2012
    ..abstract_text> ..
  42. Cardiovascular Regulation in Hindlimb Unweighted Rats
    Eileen M Hasser; Fiscal Year: 2010
    ..SPECIFIC AIM 2: Examine central mechanisms within the paraventricular nucleus (PVN) of the hypothalamus that are altered by cardiovascular deconditioning. ..
  43. Angiotensin and neuroimmune activation in hypertension
    Colin Sumners; Fiscal Year: 2013
    ..Thus, outcomes of this investigation will be valuable for paradigm changing approaches for the treatment of resistant neurogenic hypertension. ..
  44. Hypothalamic and Limbic Forebrain Stress Reactivity
    Layla Banihashemi; Fiscal Year: 2012
    ..Our proposed experiments will enhance our understanding of the neural circuitry underlying risk for coronary heart disease. ..
  45. Role of Oxytocin Signaling in the Pathogenesis of Diet-Induced Obesity
    JAMES ERNEST BLEVINS; Fiscal Year: 2013
    ....
  46. Central Viscerosensory Circuits - Structure and Function
    LINDA M RINAMAN; Fiscal Year: 2013
    ..Experimental outcomes could lead to the development of new therapeutic options for treating stress-related emotional pathologies. ..
  47. CNS PPARg, Stress, &Cardiovascular Disease
    Karen Ryan; Fiscal Year: 2013
    ..The CAC will remain active mentors, a role that includes providing constructive critiques of Dr. Ryan's first R01 submission. ..
  48. MORPHINE ACTIONS ON THE IMMUNE SYSTEM
    Sulie L Chang; Fiscal Year: 2012
    ..abstract_text> ..
  49. Paraventricular thalamic nucleus: Role of orexin and opioids in ethanol intake
    JESSICA ROSE BARSON; Fiscal Year: 2013
    ....
  50. Acute Corticosteriod Actions in the Hypothalamus
    Jeffrey G Tasker; Fiscal Year: 2013
    ..abstract_text> ..
  51. NEUROPEPTIDES AND THEIR PHYSIOLOGICAL CONTROL
    Alan G Watts; Fiscal Year: 2013
    ..These experiments are designed to generate a new and innovative view of the functional organization of the neural networks responsible for controlling CRH neuroendocrine function. ..
  52. MIF: A novel CNS regulator of cardiovascular function
    Colin Sumners; Fiscal Year: 2013
    ..Information gained from these studies may lead to the development of novel therapeutic targets for hypertension. ..
  53. NEURAL MECHANISMS OF ANOREXIA
    Alan G Watts; Fiscal Year: 2012
    ..abstract_text> ..
  54. Melanocortin-4 Receptor Traffic and Signaling
    Giulia Baldini; Fiscal Year: 2012
    ..It is anticipated that these studies will broaden our understanding of traffic and signaling of MC4R and of obesity- linked variants and will help find new targets for therapies against obesity. ..
  55. Neuroendocrine Supersensitivity of 5-HT2A Receptors
    GONZALO ANDRES CARRASCO; Fiscal Year: 2010
    ..These studies will further our understanding of the neurobiological mechanisms associated with withdrawal from cannabinoids, in order to refine therapy to reduce craving and relapse. ..
  56. Role of DMH LepR-b neurons in leptin action
    Margaret B Allison; Fiscal Year: 2013
    ..At the completion of these studies we hope to gain critical insight into the mechanisms of leptin action in the central nervous system. ..
  57. Neuroanatomical mapping and functional analysis of PVH oxytocin neurons
    AMY KATHERINE SUTTON; Fiscal Year: 2012
    ....
  58. Development of Leptin-Sensitive Hypothalamic Pathways
    Richard B Simerly; Fiscal Year: 2010
    ....
  59. Glucocorticoid Negative Feedback: Intrinsic and Extrinsic Mechanisms
    Robert L Spencer; Fiscal Year: 2012
    ..abstract_text> ..
  60. Neural Substrates of Electroacupuncture in Cardiovascular Control
    STEPHANIE CHEE YEE TJEN-A-LOOI; Fiscal Year: 2013
    ..Anatomical, physiological, electrophysiological, pharmacological and molecular approaches will be used in the proposed studies that are highly relevant to patients that have the potential to benefit from clinical acupuncture. ..
  61. Central Cardiovascular Regulation and Proangiotensin-12
    Hreday N Sapru; Fiscal Year: 2013
    ..The significance of the proposed studies is high considering that over 61 million Americans suffer from some type of cardiovascular disease which is the leading cause of death in this country. ..
  62. Investigating GABAergic control of the HPA axis in the co-morbidity of depression
    JAMIE LYNN MAGUIRE; Fiscal Year: 2013
    ..We have developed a unique mouse model, which is deficient in the GABAergic regulation of the stress response, to investigate the impact on the co-morbidity of depression and epilepsy. ..
  63. Role and Mechanisms of Prolactin on HPA Axis Activation Following Stress
    James Janik; Fiscal Year: 2009
    ..Discovering the neuroendocrine mechanisms regulating the stress response will lead to improved treatments of stress-related disorders, and positively impact human health. ..
  64. MOLECULAR BASIS FOR ETHANOL-INDUCED HYPOTHYROIDISM
    Robert Zoeller; Fiscal Year: 1993
    ....
  65. HYPOTHALAMIC OPIATES IN OBESITY-ACCELERATED HYPERTENSION
    Robin Rockhold; Fiscal Year: 1991
    ..The observed changes in hemodynamics, renal and sympatho-adrenal function may suggest more appropriate and effective therapeutic interventions...
  66. COCAINE & MATERNAL AGGRESSION--OXYTOCINERGIC MECHANISMS
    JOSEPHINE JOHNS; Fiscal Year: 2005
    ..OXY levels in the amygdala will be assessed following the behavioral testing. ..
  67. SUBCORTICAL MODULATION OF THE DORSAL VAGAL COMPLEX
    Xueguo Zhang; Fiscal Year: 2002
    ....
  68. ROLE OF GABAERGIC NEURONS IN AUTONOMIC NUCLEI
    BANG HWANG; Fiscal Year: 1991
    ..to elucidate the role of GABAergic neurons in regulation of the vasopressin (VP) neurons in (a) the paraventricular hypothalamic nucleus (PVN) - nucleus tractus solitarius (NTS) autonomic pathway, and (b) the PVN - pituitary ..
  69. Hypothalamic Type 2 Deiodinase in Metabolism Regulation
    Sabrina Diano; Fiscal Year: 2005
    ....