dentate gyrus

Summary

Summary: Gray matter situated above the gyrus hippocampi. It is composed of three layers. The molecular layer is continuous with the HIPPOCAMPUS in the hippocampal fissure. The granular layer consists of closely arranged spherical or oval neurons, called granule cells, whose AXONS pass through the polymorphic layer ending on the DENDRITES of pyramidal cells in the hippocampus.

Top Publications

  1. ncbi Functional neurogenesis in the adult hippocampus
    Henriette van Praag
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 415:1030-4. 2002
  2. pmc Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    Jason S Snyder
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 476:458-61. 2011
  3. pmc A functional role for adult hippocampal neurogenesis in spatial pattern separation
    C D Clelland
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 325:210-3. 2009
  4. ncbi Pattern separation in the dentate gyrus and CA3 of the hippocampus
    Jill K Leutgeb
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 315:961-6. 2007
  5. pmc Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
    Toshiaki Nakashiba
    Department of Biology, RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 149:188-201. 2012
  6. pmc Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Amar Sahay
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    Nature 472:466-70. 2011
  7. pmc miR-132 mediates the integration of newborn neurons into the adult dentate gyrus
    Bryan W Luikart
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e19077. 2011
  8. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
  9. ncbi Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
  10. ncbi Neurogenesis in the adult is involved in the formation of trace memories
    T J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 410:372-6. 2001

Detail Information

Publications304 found, 100 shown here

  1. ncbi Functional neurogenesis in the adult hippocampus
    Henriette van Praag
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 415:1030-4. 2002
    There is extensive evidence indicating that new neurons are generated in the dentate gyrus of the adult mammalian hippocampus, a region of the brain that is important for learning and memory...
  2. pmc Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    Jason S Snyder
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 476:458-61. 2011
    ..These findings identify a small subset of neurons within the dentate gyrus that are critical for hippocampal negative control of the HPA axis and support a direct role for adult ..
  3. pmc A functional role for adult hippocampal neurogenesis in spatial pattern separation
    C D Clelland
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Science 325:210-3. 2009
    The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation-the formation of distinct and orthogonal representations of mnemonic information-and also undergoes neurogenesis throughout life...
  4. ncbi Pattern separation in the dentate gyrus and CA3 of the hippocampus
    Jill K Leutgeb
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 315:961-6. 2007
    Theoretical models have long pointed to the dentate gyrus as a possible source of neuronal pattern separation...
  5. pmc Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
    Toshiaki Nakashiba
    Department of Biology, RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 149:188-201. 2012
    Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from less active, ..
  6. pmc Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Amar Sahay
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    Nature 472:466-70. 2011
    ..is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout life...
  7. pmc miR-132 mediates the integration of newborn neurons into the adult dentate gyrus
    Bryan W Luikart
    The Vollum Institute, Oregon Health and Science University, Portland, Oregon, United States of America
    PLoS ONE 6:e19077. 2011
    ..The correlation of miR-132 knockdown to increased proinflammatory molecular expression may indicate a mechanistic link whereby miR-132 functions as an endogenous mediator of activity-dependent integration in vivo...
  8. pmc GABA regulates synaptic integration of newly generated neurons in the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Departments of Neurology and Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 439:589-93. 2006
    ..Here we show that newborn granule cells in the dentate gyrus of the adult hippocampus are tonically activated by ambient GABA (gamma-aminobutyric acid) before being ..
  9. ncbi Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
    ..These findings suggest that the behavioral effects of chronic antidepressants may be mediated by the stimulation of neurogenesis in the hippocampus...
  10. ncbi Neurogenesis in the adult is involved in the formation of trace memories
    T J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    Nature 410:372-6. 2001
    ..These results indicate that newly generated neurons in the adult are not only affected by the formation of a hippocampal-dependent memory, but also participate in it...
  11. ncbi Transient expression of doublecortin during adult neurogenesis
    Jason P Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Comp Neurol 467:1-10. 2003
    ..These areas, mainly the dentate gyrus and the lateral ventricle wall in conjunction with the rostral migratory stream and olfactory bulb, retain the ..
  12. ncbi Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    Chunmei Zhao
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 26:3-11. 2006
    Adult neurogenesis in the dentate gyrus may contribute to hippocampus-dependent functions, yet little is known about when and how newborn neurons are functional because of limited information about the time course of their connectivity...
  13. pmc In vivo fate analysis reveals the multipotent and self-renewal capacities of Sox2+ neural stem cells in the adult hippocampus
    Hoonkyo Suh
    Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Cell Stem Cell 1:515-28. 2007
    ..An asymmetric contribution of Sox2+ NSCs may play an important role in maintaining the constant size of the NSC pool and producing newly born neurons during adult neurogenesis...
  14. pmc Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies
    Alexander Garthe
    CRTD, Center for Regenerative Therapies Dresden, Dresden, Germany
    PLoS ONE 4:e5464. 2009
    ..The reduction of neurogenesis did not alter longterm potentiation in CA3 and the dentate gyrus but abolished the part of dentate gyrus LTP that is attributed to the new neurons...
  15. pmc Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation
    James B Aimone
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 70:589-96. 2011
    ..See the related Perspective from Sahay, Wilson, and Hen, "Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb," in this issue of Neuron...
  16. ncbi Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
    H A Cameron
    Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892 USA
    J Comp Neurol 435:406-17. 2001
    Knowing the rate of addition of new granule cells to the adult dentate gyrus is critical to understanding the function of adult neurogenesis...
  17. pmc Dentate gyrus-specific knockdown of adult neurogenesis impairs spatial and object recognition memory in adult rats
    Sebastian Jessberger
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Learn Mem 16:147-54. 2009
    New granule cells are born throughout life in the dentate gyrus of the hippocampal formation...
  18. ncbi Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease
    Jorge J Palop
    Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA
    Neuron 55:697-711. 2007
    ..develop AD-like abnormalities, including cognitive deficits and depletions of calcium-related proteins in the dentate gyrus, a region critically involved in learning and memory...
  19. pmc Spatial firing correlates of physiologically distinct cell types of the rat dentate gyrus
    Joshua P Neunuebel
    Krieger Mind Brain Institute, Johns Hopkins University, Baltimore, Maryland, 21218, USA
    J Neurosci 32:3848-58. 2012
    The dentate gyrus (DG) occupies a key position in information flow through the hippocampus. Its principal cell, the granule cell, has spatially selective place fields...
  20. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..The dentate gyrus subregion has been suggested to fulfill this role...
  21. ncbi The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis
    N Kee
    Department of Physiology, Medical Sciences Building, University of Toronto, Ont, Canada M5S 1A8
    J Neurosci Methods 115:97-105. 2002
    Adult animals continue to produce new neurons in the dentate gyrus of hippocampus...
  22. pmc A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain
    Shaoyu Ge
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 54:559-66. 2007
    ....
  23. pmc Detection of an immature dentate gyrus feature in human schizophrenia/bipolar patients
    N M Walton
    CNS, Astellas Research Institute of America LLC, Skokie, IL 60077, USA
    Transl Psychiatry 2:e135. 2012
    ..The hippocampi of these mice possess a conserved pathophysiological alteration; we term the 'immature dentate gyrus' (iDG), characterized by increased numbers of calretinin-positive immature neuronal progenitors, a dearth of ..
  24. pmc Antidepressants increase neural progenitor cells in the human hippocampus
    Maura Boldrini
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York State Psychiatric Institute, 1051 Riverside Drive, Box 42, New York, NY 10032, USA
    Neuropsychopharmacology 34:2376-89. 2009
    ..serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants (TCAs) increase neurogenesis in the dentate gyrus (DG) of rodents and nonhuman primates...
  25. pmc Unique processing during a period of high excitation/inhibition balance in adult-born neurons
    Antonia Marin-Burgin
    Laboratorio de Plasticidad Neuronal, Instituto Leloir, Instituto de Investigaciones Bioquímicas de Buenos Aires Consejo Nacional de Investigaciones Científicas y Técnicas CONICET, Avenida Patricias Argentinas 435, 1405 Buenos Aires, Argentina
    Science 335:1238-42. 2012
    The adult dentate gyrus generates new granule cells (GCs) that develop over several weeks and integrate into the preexisting network...
  26. ncbi Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada
    Hippocampus 21:1348-62. 2011
    ....
  27. pmc Pattern separation in the human hippocampal CA3 and dentate gyrus
    Arnold Bakker
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD, USA
    Science 319:1640-2. 2008
    ..Computational models have stressed the role of the hippocampus and, in particular, the dentate gyrus and its projections into the CA3 subregion in pattern separation. We used high-resolution (1...
  28. ncbi Theta oscillations in the hippocampus
    Gyorgy Buzsaki
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey and Neurological Institute of New Jersey, Newark, NJ 07102, USA
    Neuron 33:325-40. 2002
    ..Nevertheless, numerous critical issues regarding both the generation of theta oscillations and their functional significance remain challenges for future research...
  29. ncbi NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
    Ayumu Tashiro
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Nature 442:929-33. 2006
    New neurons are continuously integrated into existing neural circuits in adult dentate gyrus of the mammalian brain. Accumulating evidence indicates that these new neurons are involved in learning and memory...
  30. ncbi Astrocytes give rise to new neurons in the adult mammalian hippocampus
    B Seri
    The Rockefeller University, New York, New York 10021, USA
    J Neurosci 21:7153-60. 2001
    Neurogenesis in the dentate gyrus of the hippocampus persists throughout life in many vertebrates, including humans. The progenitors of these new neurons reside in the subgranular layer (SGL) of the dentate gyrus...
  31. pmc Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum
    Martin H Teicher
    Developmental Biopsychiatry Research Program and Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
    Proc Natl Acad Sci U S A 109:E563-72. 2012
    ..show that the key consequences of stress exposure on the hippocampus are suppression of neurogenesis in the dentate gyrus (DG) and dendritic remodeling in the cornu ammonis (CA), particularly the CA3 subfield...
  32. pmc Disrupted-In-Schizophrenia 1 regulates integration of newly generated neurons in the adult brain
    Xin Duan
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, 733 N Broadway, Baltimore, MD 21205, USA
    Cell 130:1146-58. 2007
    ....
  33. pmc Neurons born in the adult dentate gyrus form functional synapses with target cells
    Nicolas Toni
    Laboratory of Genetics, Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Neurosci 11:901-7. 2008
    ..By combining retroviral expression of green fluorescent protein in adult-born neurons of the mouse dentate gyrus with immuno-electron microscopy, we found output synapses that were formed by labeled terminals on appropriate ..
  34. ncbi Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory
    Takashi Kitamura
    Mitsubishi Kagaku Institute of Life Sciences, MITILS, 11 Minamiooya, Machida, Tokyo, 194 8511, Japan
    Cell 139:814-27. 2009
    ..These observations provide a framework for understanding the mechanisms of the hippocampal-cortical complementary learning systems...
  35. ncbi Effects of electroacupuncture at Zusanli and Baihui on brain-derived neurotrophic factor and cyclic AMP response element-binding protein in the hippocampal dentate gyrus
    In Koo Hwang
    Department of Anatomy and Cell Biology, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, South Korea
    J Vet Med Sci 72:1431-6. 2010
    ..EA) at ST36 (Zusanli) and GV20 (Baihui) enhanced cell proliferation and neuroblast differentiation in the rat dentate gyrus. In this study, we investigated the possible mechanisms of EA in this effect...
  36. ncbi Extreme sensitivity of adult neurogenesis to low doses of X-irradiation
    Shinichiro Mizumatsu
    Brain Tumor Research Center, Department of Neurological Surgery, University of California at San Francisco, San Francisco, California 94143, USA
    Cancer Res 63:4021-7. 2003
    ..is unknown, it may involve loss of neural precursor cells from the subgranular zone (SGZ) of the hippocampal dentate gyrus and alterations in new cell production (neurogenesis)...
  37. pmc Fluoxetine targets early progenitor cells in the adult brain
    Juan M Encinas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 103:8233-8. 2006
    ..serotonin reuptake inhibitor antidepressant fluoxetine does not affect division of stem-like cells in the dentate gyrus but increases symmetric divisions of an early progenitor cell class...
  38. ncbi Adult neurogenesis and the plasticity of the dentate gyrus network
    Lucas A Mongiat
    Laboratory of Neuronal Plasticity, Leloir Institute CONICET, Buenos Aires, Argentina
    Eur J Neurosci 33:1055-61. 2011
    The granule cell layer (GCL) of the dentate gyrus contains neurons generated during embryonic, early postnatal and adult life...
  39. pmc Pattern separation in the dentate gyrus: a role for the CA3 backprojection
    Catherine E Myers
    Department of Psychology, Rutgers University, Newark, New Jersey, USA
    Hippocampus 21:1190-215. 2011
    ..storage, as well as pattern completion when a partial version of a familiar pattern is presented, and that the dentate gyrus (DG) is a preprocessor that performs pattern separation, facilitating storage and recall in CA3...
  40. ncbi Perisynaptic localization of delta subunit-containing GABA(A) receptors and their activation by GABA spillover in the mouse dentate gyrus
    Weizheng Wei
    Department of Neurology and Physiology, The David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 1769, USA
    J Neurosci 23:10650-61. 2003
    ..We examined the anatomical localization and physiological activation of these receptors in adult mouse dentate gyrus granule cells...
  41. pmc Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat
    K Jin
    Buck Institute for Age Research, Novato, CA 94945, USA
    Proc Natl Acad Sci U S A 98:4710-5. 2001
    ..increased the incorporation of BrdUrd into cells in two neuroproliferative regions-the subgranular zone of the dentate gyrus and the rostral subventricular zone...
  42. pmc Running enhances spatial pattern separation in mice
    David J Creer
    Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, USA
    Proc Natl Acad Sci U S A 107:2367-72. 2010
    ..These findings suggest that the addition of newly born neurons may bolster dentate gyrus-mediated encoding of fine spatial distinctions.
  43. ncbi Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
    Itaru Imayoshi
    Institute for Virus Research, Kyoto University, Shogoin Kawahara, Sakyo ku, Kyoto 606 8507, Japan
    Nat Neurosci 11:1153-61. 2008
    ..of granule neurons in the olfactory bulb and a substantial addition of granule neurons to the hippocampal dentate gyrus. Genetic ablation of newly formed neurons in adult mice led to a gradual decrease in the number of granule ..
  44. pmc Adult-born hippocampal dentate granule cells undergoing maturation modulate learning and memory in the brain
    Wei Deng
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 29:13532-42. 2009
    ..These results suggest that immature DGCs that undergo maturation make important contributions to learning and memory...
  45. ncbi Dissociating hippocampal subregions: double dissociation between dentate gyrus and CA1
    P E Gilbert
    Department of Psychology, University of Utah, Salt Lake City 84112, USA
    Hippocampus 11:626-36. 2001
    This study presents a double dissociation between the dentate gyrus (DG) and CA1. Rats with either DG or CA1 lesions were tested on tasks requiring either spatial or spatial temporal order pattern separation...
  46. ncbi High-speed imaging reveals neurophysiological links to behavior in an animal model of depression
    Raag D Airan
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Science 317:819-23. 2007
    ..We found that a simple measure of real-time activity-stimulus-evoked percolation of activity through the dentate gyrus relative to the hippocampal output subfield-accounted for induced changes in animal behavior independent of ..
  47. ncbi Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
    Jaewon Lee
    Laboratory of Neurosciences, National Institute on Aging Gerontology Research Center, Baltimore, Maryland 21224, USA
    J Neurochem 82:1367-75. 2002
    ..One day after BrdU injection the number of BrdU-labeled cells in the dentate gyrus of the hippocampus was significantly decreased in BDNF +/- mice maintained on the AL diet, suggesting that ..
  48. ncbi Immunohistological markers for staging neurogenesis in adult hippocampus
    O von Bohlen und Halbach
    Interdisciplinary Center for Neurosciences, Department of Neuroanatomy, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany
    Cell Tissue Res 329:409-20. 2007
    Neurogenesis in the adult dentate gyrus (DG) of the hippocampus occurs constitutively throughout postnatal life, and the rate of neurogenesis within the DG can be altered under various physiological and pathophysiological conditions...
  49. ncbi Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells
    Zoltan Nusser
    Department of Neurology, UCLA School of Medicine, Los Angeles, California 90095 1769, USA
    J Neurophysiol 87:2624-8. 2002
    ..GABA levels are sufficiently high to generate a powerful tonic inhibition in delta subunit-expressing dentate gyrus granule cells...
  50. pmc GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol
    D Chandra
    Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 103:15230-5. 2006
    ..The GABAA-R alpha4 subunit is expressed at high levels in the dentate gyrus and thalamus and is suspected to contribute to extrasynaptic GABAA-R-mediated tonic inhibition...
  51. ncbi Neurogenic niche modulation by activated microglia: transforming growth factor beta increases neurogenesis in the adult dentate gyrus
    Daniela Battista
    Laboratory of Neuromodulation, Leloir Institute, CONICET UBA, University of Buenos Aires, 435 Av Patricias Argentinas, Buenos Aires 1405, Argentina
    Eur J Neurosci 23:83-93. 2006
    ..We studied the dynamics of NSC proliferation and differentiation in the dentate gyrus of the hippocampus (DG) and characterized the changes of the neurogenic niche in adrenalectomized animals (ADX)..
  52. ncbi Monosynaptic inputs to new neurons in the dentate gyrus
    Carmen Vivar
    Neuroplasticity and Behavior Unit, Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA
    Nat Commun 3:1107. 2012
    Adult hippocampal neurogenesis is considered important for cognition. The integration of newborn dentate gyrus granule cells into the existing network is regulated by afferent neuronal activity of unspecified origin...
  53. ncbi Stimulation of entorhinal cortex promotes adult neurogenesis and facilitates spatial memory
    Scellig S D Stone
    Program in Neurosciences and Mental Health, The Hospital for Sick Children, Toronto, Ontario, Canada M5G1X8
    J Neurosci 31:13469-84. 2011
    ..We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG)...
  54. pmc Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus
    Mazen A Kheirbek
    Department of Neuroscience, Columbia University, New York, NY 10032, USA
    Neuron 77:955-68. 2013
    The dentate gyrus (DG), in addition to its role in learning and memory, is increasingly implicated in the pathophysiology of anxiety disorders...
  55. pmc An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
    Ana C Pereira
    The Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 104:5638-43. 2007
    ..Among all hippocampal subregions, exercise was found to have a primary effect on dentate gyrus CBV, the only subregion that supports adult neurogenesis...
  56. ncbi TNFα controls glutamatergic gliotransmission in the hippocampal dentate gyrus
    Mirko Santello
    Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland
    Neuron 69:988-1001. 2011
    Glutamatergic gliotransmission provides a stimulatory input to excitatory synapses in the hippocampal dentate gyrus. Here, we show that tumor necrosis factor-alpha (TNFα) critically controls this process...
  57. pmc Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures
    Robert J Morgan
    Department of Anatomy and Neurobiology, University of California, 193 Irvine Hall, Irvine, CA 92697, USA
    Proc Natl Acad Sci U S A 105:6179-84. 2008
    ..The dentate gyrus is an excellent circuit in which to study such functional implications because proepileptic insults cause its ..
  58. pmc A role for hilar cells in pattern separation in the dentate gyrus: a computational approach
    Catherine E Myers
    Department of Psychology, Rutgers University Newark, Newark, New Jersey, USA
    Hippocampus 19:321-37. 2009
    We present a simple computational model of the dentate gyrus to evaluate the hypothesis that pattern separation, defined as the ability to transform a set of similar input patterns into a less-similar set of output patterns, is ..
  59. pmc Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
    Joshua J Breunig
    Department of Neurobiology, Kavli Institute for Neuroscience, and Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20558-63. 2007
    ..These results provide evidence for the expansive prevalence of Notch signaling in hippocampal morphogenesis and plasticity, suggesting that Notch1 could be a target of diverse traumatic and environmental modulators of adult neurogenesis...
  60. ncbi Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo
    Elhoucine Messaoudi
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, N 5009 Bergen, Norway
    J Neurosci 27:10445-55. 2007
    ..mRNA using brief, local infusions of antisense (AS) oligodeoxynucleotides at multiple time points during dentate gyrus LTP in vivo...
  61. ncbi Adult-born neurons are necessary for extended contextual discrimination
    Sophie Tronel
    INSERM U862, Bordeaux F33077, France
    Hippocampus 22:292-8. 2012
    New neurons are continuously produced in the adult dentate gyrus of the hippocampus...
  62. pmc Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
    Juan Song
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Nature 489:150-4. 2012
    ..Our study identifies a niche cell–signal–receptor trio and a local circuitry mechanism that control the activation and self-renewal mode of quiescent adult neural stem cells in response to neuronal activity and experience...
  63. pmc Neurogenesis may relate to some but not all types of hippocampal-dependent learning
    Tracey J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Hippocampus 12:578-84. 2002
    ..Nor did MAM treatment affect exploration in the elevated plus maze. These results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal-dependent memories...
  64. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    ..Our results strongly suggest that activity-dependent modifications of CA1 synapses, mediated by NMDA receptors, play an essential role in the acquisition of spatial memories...
  65. pmc Forebrain neurogenesis after focal Ischemic and traumatic brain injury
    Steven G Kernie
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
    Neurobiol Dis 37:267-74. 2010
    ..main areas of persistent neurogenesis, the subventricular zone (SVZ)-olfactory bulb pathway and hippocampal dentate gyrus, are stimulated by brain insults such as stroke or trauma...
  66. ncbi Radiation injury and neurogenesis
    Michelle L Monje
    Department of Neurosurgery, MSLS P309, MC 5487, Stanford, CA, USA
    Curr Opin Neurol 16:129-34. 2003
    ..This is especially true when the radiation field involves the temporal lobes. The cause of this debilitating dysfunction is currently unknown and untreatable...
  67. pmc Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
    Yaisa Andrews-Zwilling
    Gladstone Institute of Neurological Disease, University of California, San Francisco, San Francisco, California 94158, USA
    J Neurosci 30:13707-17. 2010
    ..Consequently, reducing Tau and enhancing GABA signaling are potential strategies to treat or prevent apoE4-related Alzheimer's disease...
  68. pmc Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo
    Karin Wibrand
    Department of Biomedicine and Bergen Mental Health Research Center, University of Bergen, Jonas Lies vei 91, N 5009 Bergen, Norway
    Eur J Neurosci 31:636-45. 2010
    ..Here, we examined miRNA expression during long-term potentiation (LTP) in the dentate gyrus of adult anesthetized rats...
  69. ncbi Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus
    Beate Winner
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 32:16906-16. 2012
    ..levels modulate adult neurogenesis and the development of dendritic arborization and spines in the dentate gyrus, in which new neurons are constantly added...
  70. pmc TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus
    Andres E Chavez
    Department of Neuroscience, Albert Einstein College of Medicine, New York, New York, USA
    Nat Neurosci 13:1511-8. 2010
    ..However, we found that TRPV1 suppressed excitatory transmission in rat and mouse dentate gyrus by regulating postsynaptic function in an input-specific manner...
  71. pmc Oscillatory dynamics in the hippocampus support dentate gyrus–CA3 coupling
    Thomas Akam
    University College London Institute of Neurology, University College London, London, UK
    Nat Neurosci 15:763-8. 2012
    Gamma oscillations in the dentate gyrus and hippocampal CA3 show variable coherence in vivo, but the mechanisms and relevance for information flow are unknown...
  72. pmc Discovery of a proneurogenic, neuroprotective chemical
    Andrew A Pieper
    Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9152, USA
    Cell 142:39-51. 2010
    ..Eight of 1000 small molecules tested enhanced neuron formation in the subgranular zone of the dentate gyrus. Among these was an aminopropyl carbazole, designated P7C3, endowed with favorable pharmacological properties...
  73. pmc Ensemble place codes in hippocampus: CA1, CA3, and dentate gyrus place cells have multiple place fields in large environments
    Eunhye Park
    Department of Physiology and Pharmacology, The State University of New York SUNY, Downstate Medical Center, Brooklyn, New York, United States of America
    PLoS ONE 6:e22349. 2011
    ..of hippocampal place codes by characterizing the spatial firing properties of place cells in the CA1, CA3, and dentate gyrus (DG) hippocampal subdivisions as rats foraged in a standard 76-cm cylinder as well as a larger-than-standard ..
  74. pmc Effects of adult-generated granule cells on coordinated network activity in the dentate gyrus
    Clay O Lacefield
    Department of Neuroscience, Columbia University, New York State Psychiatric Institute, 1051 Riverside Dr, Kolb Annex, Unit 87, NewYork, NY 10032, USA
    Hippocampus 22:106-16. 2012
    Throughout the adult life of most mammals, new neurons are continuously generated in the dentate gyrus of the hippocampal formation...
  75. pmc Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
    E Gould
    Department of Psychology, Princeton University, Green Hall, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 95:3168-71. 1998
    Although granule cells continue to be added to the dentate gyrus of adult rats and tree shrews, this phenomenon has not been demonstrated in the dentate gyrus of adult primates...
  76. ncbi Dendritic integration in hippocampal dentate granule cells
    Roland Krueppel
    Laboratory for Cognition Research and Experimental Epileptology, Department of Epileptology, University of Bonn, Sigmund Freud Strase 25, 53105 Bonn, Germany
    Neuron 71:512-28. 2011
    ....
  77. ncbi Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography
    Vijayalakshmi Santhakumar
    UCLA Neurobiology BOX 951763, 63 314 CHS Los Angeles, CA 90095 1763, USA
    J Neurophysiol 93:437-53. 2005
    ..we built a biophysically realistic and anatomically representative computational model of the dentate gyrus to examine this question...
  78. ncbi Disambiguating the similar: the dentate gyrus and pattern separation
    Brandy Schmidt
    University of Connecticut, Storrs, CT, United States
    Behav Brain Res 226:56-65. 2012
    ..There is convergent evidence linking pattern separation to the dentate gyrus. Damage to the dentate gyrus reduces an organism's ability to differentiate between similar objects...
  79. pmc Aging-related gene expression in hippocampus proper compared with dentate gyrus is selectively associated with metabolic syndrome variables in rhesus monkeys
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 30:6058-71. 2010
    ..subdivisions critical for memory/cognitive function [hippocampus proper, or cornu ammonis (CA), and dentate gyrus (DG)]. Genes that changed with aging [aging-related genes (ARGs)] were identified in each region...
  80. pmc Dynamic contribution of nestin-expressing stem cells to adult neurogenesis
    Diane C Lagace
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    J Neurosci 27:12623-9. 2007
    ..recombination in vivo, and maturing YFP+ progeny were increasingly evident in the olfactory bulb (OB) and dentate gyrus (DG) granule cell layer...
  81. ncbi The perforant path: projections from the entorhinal cortex to the dentate gyrus
    Menno P Witter
    Institute for Clinical and Experimental Neurosciences, Department of Anatomy and Neurosciences, VU University Medical Center, MF G102C, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Prog Brain Res 163:43-61. 2007
    ..provides a comprehensive description of the organization of projections from the entorhinal cortex to the dentate gyrus, which together with projections to other subfields of the hippocampal formation form the so-called perforant ..
  82. pmc Neurogliaform cells in the molecular layer of the dentate gyrus as feed-forward γ-aminobutyric acidergic modulators of entorhinal-hippocampal interplay
    Caren Armstrong
    Department of Anatomy and Neurobiology, University of California, Irvine, School of Medicine, Irvine, California 92697, USA
    J Comp Neurol 519:1476-91. 2011
    Feed-forward inhibition from molecular layer interneurons onto granule cells (GCs) in the dentate gyrus is thought to have major effects regulating entorhinal-hippocampal interactions, but the precise identity, properties, and functional ..
  83. ncbi Pro-inflammatory cytokines and their effects in the dentate gyrus
    Mark Pickering
    UCD School of Biomolecular and Biomedical Science, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    Prog Brain Res 163:339-54. 2007
    ..modulatory molecules, the pro-inflammatory cytokines, in regulating neuronal function and viability in the dentate gyrus of the hippocampus...
  84. ncbi Pregnancy-stimulated neurogenesis in the adult female forebrain mediated by prolactin
    Tetsuro Shingo
    Genes and Development Research Group, Department of Cell Biology and Anatomy, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada T2N 4N1
    Science 299:117-20. 2003
    ..Neurogenesis occurs even in females that mate with sterile males. These findings imply that forebrain olfactory neurogenesis may contribute to adaptive behaviors in mating and pregnancy...
  85. ncbi Adult neurogenesis and functional plasticity in neuronal circuits
    Pierre Marie Lledo
    Laboratory of Perception and Memory, Institut Pasteur, Centre National de la Recherche Scientifique Unit de Recherche Associée 2182, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Rev Neurosci 7:179-93. 2006
    ..In two areas of the adult brain - the olfactory bulb and the dentate gyrus - new neurons are generated throughout life and form an integral part of the normal functional circuitry...
  86. ncbi Epileptogenesis in the dentate gyrus: a critical perspective
    F Edward Dudek
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108, USA
    Prog Brain Res 163:755-73. 2007
    The dentate gyrus has long been a focal point for studies on the molecular, cellular, and network mechanisms responsible for epileptogenesis in temporal lobe epilepsy (TLE)...
  87. ncbi Reduced cell proliferation in the dentate gyrus is not correlated with the development of learned helplessness
    Barbara Vollmayr
    Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 54:1035-40. 2003
    ..A plethora of indirect findings suggests that mood disorders may be caused by or result in structural changes in the brain, namely decreased hippocampal cell proliferation...
  88. ncbi Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis
    H E Scharfman
    Center for Neural Recovery and Rehabilitation Research, Helen Hayes Hospital, West Haverstraw, New York 10993 1195, USA
    J Neurosci 20:6144-58. 2000
    A group of neurons with the characteristics of dentate gyrus granule cells was found at the hilar/CA3 border several weeks after pilocarpine- or kainic acid-induced status epilepticus...
  89. pmc Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults
    Michael A Yassa
    Center for Neurobiology of Learning and Memory, University of California, Irvine, 211 Qureshey Research Laboratory, Irvine, California 92697, USA
    Hippocampus 21:968-79. 2011
    ..We also found a related increase in CA3/dentate gyrus activity levels during an fMRI contrast that stresses pattern separation abilities...
  90. ncbi Encoding versus retrieval of spatial memory: double dissociation between the dentate gyrus and the perforant path inputs into CA3 in the dorsal hippocampus
    Inah Lee
    Department of Neurobiology and Anatomy, University of Texas Houston Medical School, Houston, Texas, USA
    Hippocampus 14:66-76. 2004
    ..The perforant path (PPCA3) and dentate gyrus (DG)-mediated mossy fibers (MFs) compose major afferent inputs into CA3...
  91. ncbi Increased dentate gyrus excitability in neuroligin-2-deficient mice in vivo
    Peter Jedlicka
    Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Neuroscience Center, D 60590 Frankfurt am Main, Germany
    Cereb Cortex 21:357-67. 2011
    ..Here, we studied network activity in the dentate gyrus of NL2-deficient mice following perforant path (PP) stimulation in vivo...
  92. ncbi Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus
    Bettina Seri
    University of California, San Francisco, Department of Neurological Surgery and Program in Developmental and Stem Cell Research, San Francisco, California 94143, USA
    J Comp Neurol 478:359-78. 2004
    New neurons continue to be born in the subgranular zone (SGZ) of the dentate gyrus in the hippocampus of adult mammals, including humans...
  93. pmc Spatial learning depends on both the addition and removal of new hippocampal neurons
    David Dupret
    INSERM U862, Bordeaux Neuroscience Research Center, Bordeaux, France
    PLoS Biol 5:e214. 2007
    ..In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons...
  94. pmc Expression of tryptophan 2,3-dioxygenase in mature granule cells of the adult mouse dentate gyrus
    Koji Ohira
    Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake 470 1192, Japan
    Mol Brain 3:26. 2010
    New granule cells are continuously generated in the dentate gyrus of the adult hippocampus...
  95. ncbi Spatial learning affects immature granule cell survival in adult rat dentate gyrus
    P Ambrogini
    Institute of Physiological Sciences, University of Urbino, I 61029, Urbino, Italy
    Neurosci Lett 286:21-4. 2000
    Neurogenesis occurs throughout life in mammalian dentate gyrus. The effect of learning on newborn cell survival was studied in rat. Rats were trained on a hippocampus-dependent spatial learning task by using Morris water maze...
  96. ncbi Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus
    Atsushi Enomoto
    Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Neuron 63:774-87. 2009
    ..Although roles for DISC1 in postnatal neurogenesis in the dentate gyrus (DG) have recently emerged, it is not known how DISC1 and its interacting proteins govern the migration, ..
  97. pmc Failure of neuronal maturation in Alzheimer disease dentate gyrus
    Bin Li
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 67:78-84. 2008
    The dentate gyrus, an important anatomic structure of the hippocampal formation, is one of the major areas in which neurogenesis takes place in the adult mammalian brain...
  98. ncbi Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone
    Mounira Banasr
    Cellular and Functional Neurobiology Unit, CNRS, Marseille, France
    Neuropsychopharmacology 29:450-60. 2004
    ..5-HT receptor subtypes involved in the regulation of cell proliferation in the subgranular layer (SGL) of the dentate gyrus (DG) and the subventricular zone (SVZ) and to determine the long-term changes in adult neurogenesis...
  99. ncbi Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway
    Shuken Boku
    Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neuropsychopharmacology 34:805-15. 2009
    ..Here we established the culture system of adult rat dentate gyrus-derived neural precursor cells (ADPs) and examined the effects of dexamethasone (DEX), an agonist of ..
  100. ncbi Stimulation of neurogenesis in the hippocampus of the adult rat by fluoxetine requires rhythmic change in corticosterone
    Guo Jen Huang
    Department of Anatomy and Cambridge Centre for Brain Repair, University of Cambridge, United Kingdom
    Biol Psychiatry 59:619-24. 2006
    Fluoxetine stimulates proliferation of progenitor cells in the dentate gyrus of the adult hippocampus. There are suggestions that this action may underlie the therapeutic effects of such drugs in depression...
  101. ncbi Nicotinic receptor-mediated enhancement of long-term potentiation involves activation of metabotropic glutamate receptors and ryanodine-sensitive calcium stores in the dentate gyrus
    Philip Welsby
    Department of Physiology, Trinity College, Dublin 2, Ireland
    Eur J Neurosci 24:3109-18. 2006
    ..In the present study, the mechanisms of nicotinic enhancement of LTP were investigated in the rat dentate gyrus in vitro...

Research Grants74

  1. NEUROPHYSIOLOGICAL STUDY OF CA1 SYNAPTIC REORGANIZATION
    JOSE CAVAZOS; Fiscal Year: 2003
    ..fiber pathway that forms new recurrent excitatory collaterals leading to a permanent hyperexcitability of the dentate gyrus. The proposed research investigates the exciting possibility that this putative cellular mechanism of epilepsy,..
  2. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..EB protects against status epilepticus (SE)-induced neuronal damage in the hilus of the hippocampal dentate gyrus. This protection occurs only in female but not in male rats...
  3. Adult Neurogenesis: Regulation By Sleep
    DENNIS J MCGINTY; Fiscal Year: 2013
    ..We have shown that sustained sleep fragmentation (SF) strongly inhibits adult hippocampal dentate gyrus (DG) neurogenesis, including both cell proliferation and maturation, and that this inhibition is not due to ..
  4. Novel neurotrophic therapy in a mouse model of ALS
    Alpaslan Dedeoglu; Fiscal Year: 2013
    ..spatial memory and this effect was associated with increased angiogenesis and neuronal spine density in the dentate gyrus of the hippocampus in mice...
  5. Effect of Major Depression and antidepressants on human neurogenesis
    Maura Boldrini; Fiscal Year: 2013
    Neurogenesis occurs in the dentate gyrus (DG) of the hippocampal formation (HF) of adult mammals and is altered in both health (aging) and disease (stress, neurological damage) states...
  6. Effects of Alcohol on Stem Cells in the Adult Brain
    Michael W Miller; Fiscal Year: 2012
    ..In the adolescent and adult, this production is largely restricted to cerebral cortex, and particularly, the dentate gyrus. The environment of a NSC defines its proliferative activity and capability...
  7. Comparative effectiveness of Brain Imaging and Blood Biomarkers in Alzheimer??s d
    Orly Lazarov; Fiscal Year: 2010
    ..life in two discrete areas in the adult brain: the subventricular zone and the subgranule layer of the dentate gyrus. Increasing evidence suggests that newly formed neurons integrate in specific brain areas and play a role in ..
  8. Trophic factors and regulation of hippocampal neuroplasticity in the human brain
    Maura Boldrini; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Neurogenesis, or the generation of new neurons, occurs in the dentate gyrus (DG) of the hippocampal formation (HF) and it is increased by antidepressant treatment (ADT) in adult mammals including ..
  9. Mapping DNA methylation in hippocampal neurons through bisulfite sequencing
    Guoping Fan; Fiscal Year: 2012
    ..In Aim 2, we will map genome-wide methylation patterns in hippocampal dentate gyrus neurons in control and seizure conditions through shotgun bisulfate sequencing (BS-Seq) and determine the ..
  10. ALTERATIONS IN ADULT NEUROGENESIS DURING WEST NILE VIRUS ENCEPHALITIS
    MICHAEL JOHN VASEK; Fiscal Year: 2013
    ..applicant): Adult neurogenesis is a tightly regulated process emanating from two specific brain regions: the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) along the lateral ventricle...
  11. Chemical Genomic Approaches to Neurobiology of DISC1
    Li Huei Tsai; Fiscal Year: 2013
    ..In the dentate gyrus, DISC1 loss of function causes reduced proliferation of adult neural progenitors, which is accompanied by ..
  12. Identifying neurons and circuits critical for epileptogenesis
    Istvan Mody; Fiscal Year: 2013
    ..the key elements in epileptogenesis, leading to TLE following a precipitating brain insult, are a group of dentate gyrus granule cells that were "caught" by the insult at the most plastic stage of their development...
  13. Environmental Enrichment and Neuronal Turnover in the Brain
    Flora M Vaccarino; Fiscal Year: 2010
    ..The hippocampal dentate gyrus and the olfactory bulb continue to generate new neurons postnatally, but this process becomes less prominent ..
  14. Hippocampal neurodifferentiation study in aging mice by in vivo microendoscopy
    Mark J Schnitzer; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The hippocampal dentate gyrus (DG) is the only area in the adult human brain that continually exhibits neurogenesis, the formation of new neurons from stem and progenitor cells...
  15. Bidirectional Tyrosine Kinase Signaling
    MARK J HENKEMEYER; Fiscal Year: 2012
    ..self-renewing stem and transient-amplifying progenitor cells in the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) divide, migrate a short distance, and differentiate into new granule cell neurons that integrate into the ..
  16. Adenosine Receptors and Ethanol Withdrawal
    TRACY RENEE BUTLER; Fiscal Year: 2010
    ..subtypes and the NMDA NR1 and NR2B subunits to quantify receptor density in the primary cell layers of the dentate gyrus, and the CA3 and CAI regions of the hippocampus...
  17. EFFECTS OF CHEMOTHERAPY AGENTS ON NEUROGENESIS IN ADULT MOUSE HIPPOCAMPUS
    EDWARD TODD WEBER; Fiscal Year: 2010
    ..These impairments of memory are accompanied by impaired cell proliferation in the dentate gyrus, although a causal relationship impairments has not been conclusively demonstrated...
  18. Astrocytes and Ischemic Brain Injury
    Rona G Giffard; Fiscal Year: 2013
    ..brief global cerebral ischemia causes delayed loss of CA1 hippocampal neurons while sparing nearby hippocampal dentate gyrus (DG) neurons...
  19. Neural Stem Cell-Selective Drug Target for Small Molecule Therapy of Brain Tumors
    SCOTT MCNEAR THACHER; Fiscal Year: 2012
    ..is required for neural stem cell proliferation and is selectively expressed in the subventricular zone and the dentate gyrus, where NSCs are found...
  20. Novel actions of neurosteroids on GABA (A) receptor trafficking
    Stephen J Moss; Fiscal Year: 2013
    ..from [unreadable]4[unreadable]3 and ? subunits, which mediate the majority of tonic inhibition in the dentate gyrus and thalamus...
  21. MeCP2 Modulation of BDNF Signaling: Shared Mechanisms of Rett and Autism
    Lucas D Pozzo-Miller; Fiscal Year: 2013
    ..synapse function in area CA3;(2) test whether activity-dependent BDNF release from mossy fibers, the axons of dentate gyrus granule cells, is reduced in neuronal Mecp2 null mice;(3) generate a novel RTT model - dentate granule cell-..
  22. Transnasal Delivery of Chemokine Analogs in mouse NeuroAIDS Models
    Stuart A Lipton; Fiscal Year: 2013
    ..Active neurogenesis normally occurs throughout life in the dentate gyrus in the hippocampus...
  23. Experience-Dependent Synaptogenesis in Adult-Generated Neurons
    JESSICA CHANCEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The dentate gyrus (DG) relays information from the cortex to the hippocampus, a brain region critical for learning and memory...
  24. Signaling cascades and memory deficits during aging
    Thomas C Foster; Fiscal Year: 2010
    ..The studies will examine signaling cascades in two fields of the hippocampus (CA1 and the dentate gyrus) of rats at different ages in order to distinguish when and where changes associated with memory deficits ..
  25. Beyond allergy: Mast cells mediate brain-behavior-immune interactions.
    Katherine M Nautiyal; Fiscal Year: 2010
    ..For example, serotonin (a major mast cell mediator) in the hippocampus influences neurogenesis in the dentate gyrus and results in changes in anxiety and depression...
  26. Stem Cell Transplantation for Epilepsy
    JANICE RAE NAEGELE; Fiscal Year: 2013
    ..the mechanisms regulating synaptic integration of transplanted GABAergic interneurons transplanted into the dentate gyrus of the hippocampus in the adult nervous system of mice with pilocarpine-induced TLE...
  27. CHEMOKINE RECEPTOR FUNCTION IN THE NERVOUS SYSTEM
    Richard J Miller; Fiscal Year: 2013
    ..Thus, in CXCR4 chemokine receptor knockout mice structures in the nervous system such as the dentate gyrus (central nervous system) or dorsal root ganglia (peripheral nervous system) failed to develop properly...
  28. CORTICOTROPIN RELEASING HORMONE SIGNALING AND NEWBORN NEURON CIRCUIT INTEGRATION
    Isabella Garcia; Fiscal Year: 2013
    ..Two brain areas that show continued neurogenesis include the subgranular layer of the hippocampal dentate gyrus, and the subventricular zone (SVZ) of the olfactory system...
  29. GABA Receptors and Hilar Neuron Survival in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    Project Summary Loss of neurons in the hilus of the dentate gyrus is one of the most consistent morphological findings in humans with temporal lobe epilepsy and related models of acquired epilepsy...
  30. Mechanisms Underlying Treatment-Resistant Depression and Anxiety in Mouse Models
    Benjamin A Samuels; Fiscal Year: 2013
    ..We found significant activation of TGFbeta signaling in the dentate gyrus in responders to SSRI treatment, but not in untreated animals or non-responders...
  31. Exercise, Age-Related Memory Decline, and Hippocampal Function.
    Scott A Small; Fiscal Year: 2013
    ..A range of in vivo and post-mortem studies have converged on the dentate gyrus (DG) as the hippocampal subregion differentially targeted by the aging process...
  32. Neuronal-Glial Dialogue and Cognition
    Carmelina Gemma; Fiscal Year: 2012
    ..to aged rats increases proliferation of endogenous neuronal progenitors in the subgranular zone of the dentate gyrus, while blocking the function of CX3CR1 in young rats decreases neuronal progenitor cell proliferation in the ..
  33. Exploiting the hair-brain connection to treat perinatal brain disease
    SAMUEL JEREMY PLEASURE; Fiscal Year: 2013
    ..diffuses from the cells of origin to act within the brain to regulate the development of the hippocampal dentate gyrus and the migration of oligodendrocyte progenitors within the cortex at late embryonic and early postnatal ..
  34. Ectopic Granule Cells in the Dentate Gyrus
    Helen E Scharfman; Fiscal Year: 2012
    ..provided by applicant): It has been suggested that postnatal neurogenesis of granule cells (GCs) in the adult dentate gyrus serves important functions related to cognition and mood regulation, and that impairments in postnatal ..
  35. CRCNS: Computational Model for Neural Stem Cell Divisions in the Adult Brain
    Alexei Koulakov; Fiscal Year: 2013
    ..In one of them, the hippocampal dentate gyrus, new neurons may be important for learning, memory, and mood...
  36. Signaling cascades and memory deficits during aging
    Thomas C Foster; Fiscal Year: 2013
    ..The studies will examine signaling cascades in two fields of the hippocampus (CA1 and the dentate gyrus) of rats at different ages in order to distinguish when and where changes associated with memory deficits ..
  37. Cytosolic Phospholipase A2 Alpha in Stroke Injury
    Adam Sapirstein; Fiscal Year: 2010
    ..We have now identified KIDS- cPLA2a, a novel form of cPLA2a, which is specifically induced in the dentate gyrus and protects neurons...
  38. Synaptic regulation of mTOR-dependent protein synthesis at synapses
    PATRICIA SALGADO; Fiscal Year: 2013
    ..frequency stimulation of the perforant path strongly activates phosphorylation of S6 in granule cells of the dentate gyrus and in the portion of the dendrites contacted by active synapses suggesting a role for S6 phosphorylation in ..
  39. Diverse Roles of Adult Dentate Gyrus Neurogenesis
    Helen E Scharfman; Fiscal Year: 2013
    ..to new neurons, a process termed adult neurogenesis: the subventricular zone and the subgranular zone of the dentate gyrus (DG). In the DG, adult-born neurons normally become granule cells (GCs), the principal cell type...
  40. High-resolution Functional Imaging of Hippocampal Subfields in Schizophrenia
    THEODORUS G M VAN ERP; Fiscal Year: 2013
    ..Tamminga, Stan, and Wagner (2010) recently proposed a hippocampus- based psychosis model of dentate gyrus (DG) hypoglutamatergic dysfunction and reduced mossy fiber input to Cornu Amonis region 3 (CA3)...
  41. INTERNEURON BASED MECHANISMS OF TEMPORAL LOBE EPILEPSY
    Paul S Buckmaster; Fiscal Year: 2013
    ..However, in epileptic dentate gyrus, although GABAergic synapses are abundant, at least some (for example, basket cell-to-granule cell synapses) ..
  42. Juvenile trophic factors for the prevention and treatment of hippocampal aging
    Jan Krzysztof Blusztajn; Fiscal Year: 2010
    ..the hippocampus is characterized by a life-long capacity for neurogenesis - an outcome of divisions of the dentate gyrus neuronal precursor cells whose progeny can differentiate into functional granule neurons integrated into the ..
  43. Fetal Ethanol Effects on Histaminergic Regulation of Neurotransmission
    DANIEL DEXTER SAVAGE; Fiscal Year: 2013
    ..have observed that the histamine H3 receptor antagonist ABT-239 ameliorates fetal ethanol-induced deficits in dentate gyrus long-term potentiation (LTP) and learning...
  44. Synaptic Regulation of Neurogenesis in the Dentate Gyrus
    Brian E Derrick; Fiscal Year: 2012
    New neurons are continually added to the granule cell (GC) layer of the dentate gyrus during adulthood. Within 2 weeks, over 50% of these granule cells die, with most surviving GCs incorporating into the dentate circuit...
  45. THERAPEUTIC MOTOR TRAINING AND FETAL ALCOHOL EFFECTS
    William T Greenough; Fiscal Year: 2010
    ..In the dentate gyrus of the hippocampus, a region known to generate new neurons post-developmentally and into adulthood, the number ..
  46. Presynaptic Forms of Long-Term Plasticity in the CNS
    Pablo E Castillo; Fiscal Year: 2013
    ..We will also extend our studies of eCB-plasticity to the dentate gyrus and prefrontal cortex, two brain areas where eCBs are thought to play a role in the etiology of epilepsy and ..
  47. A Model of Early Alzheimer Disease
    Bradley T Hyman; Fiscal Year: 2012
    ..Destruction of the perforant pathway, the entorhinal cortex projection to the dentate gyrus, is known to deafferent the hippocampus in AD...
  48. Mitochondrial protection in post-stroke recovery
    Rona G Giffard; Fiscal Year: 2013
    ..Experimental ischemia triggers increased neurogenesis in the subventricular and dentate gyrus germinal zones. These endogenous neural precursor cells then migrate to areas of damage...
  49. The Effect of Anticipation on Episodic Memory: Motivation and Attention
    SASHA MONICA WOLOSIN; Fiscal Year: 2012
    ..on the integrity of the structures of the medial temporal lobe (MTL), including the hippocampus (CA fields, dentate gyrus, and subiculum) and parahippocampal gyrus (entorhinal, perirhinal and parahippocampal cortices)...
  50. Role of MLL Chromatin Remodeling Factor in Neural Stem Cells
    Daniel A Lim; Fiscal Year: 2012
    ..In Aim 2, we will investigate the role that Mll plays in the NSCs of the dentate gyrus subgranular layer (SGL), the other postnatal/adult NSC population...
  51. Perisomatic Inhibitory Network Dysfunction in Neurological Disease
    Vijayalakshmi Santhakumar; Fiscal Year: 2013
    ..The hippocampal dentate gyrus is at the heart of the characteristic structural and functional changes that underlie temporal lobe epilepsy...
  52. GABAergic regulation of entorhino-hippocampal excitability in epilepsy.
    Ivan Soltesz; Fiscal Year: 2013
    ..outside the hippocampus, but avoid the neighboring cells that give rise to the perforant pathway to the dentate gyrus. Here we propose to test the hypothesis that there is a significant disruption of the normally highly ..
  53. Neurogenesis and chronic cannabinoid exposure
    Colleen Cosgrove Hegg; Fiscal Year: 2013
    ..psychoactive component of marijuana, and synthetic cannabinoids on neurogenesis in two neurogenic regions, the dentate gyrus and the olfactory epithelium...
  54. Role of sFRP3-Dependent Regulation of Adult Neurogenesis in Antidepressant Action
    Mi Hyeon Jang; Fiscal Year: 2013
    ..It is now generally accepted that new neurons are continuously generated in the dentate gyrus of the hippocampus in the adult mammalian brain, and this neurogenesis has been implicated as a therapeutic ..
  55. Opiates and Adult Neurogenesis
    Amelia J Eisch; Fiscal Year: 2013
    ..Drugs of abuse, including morphine, decrease neurogenesis in the subgranular zone (SGZ) of the hippocampal dentate gyrus. This raises the possibility that opiate-induced alteration in neurogenesis leads to cognitive deficits, ..
  56. The functional significance of exercise-induced neurogenesis in cocaine reward
    Justin S Rhodes; Fiscal Year: 2013
    ..occurs before or after exercise training, in parallel with increased adult hippocampal neurogenesis in the dentate gyrus. To accomplish this aim, the order of conditioning and exercise treatments will be manipulated, and then ..
  57. Injury-induced Alterations in Limbic Functional Circuity
    Akiva S Cohen; Fiscal Year: 2012
    ..We have previously established that diminshed inhibitory efficacy compromises dentate gyrus function...
  58. Neuronal Loss and Plasticity in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..responsible for moving chloride into neurons will reduce seizure-induced damage of vulnerable neurons in the dentate gyrus. The final group of studies will test the hypothesis that genetic alterations of the GABA system or a chloride ..
  59. Role of Gi/o-Protein Inhibition of CaV2.2 Channels in Anxiety Behavior
    Arturo Andrade; Fiscal Year: 2013
    ..Our initial data showed a lower paired-pulse ratio in the medial perforant path- dentate gyrus of 37a-lacking mice compared to WT, suggesting an increase in neurotransmitter release produced by a reduction ..
  60. Fluoxetine: Sensitive Ages and Genotypes for Adverse Effects in Juvenile Monkeys
    Mari S Golub; Fiscal Year: 2013
    ..Dendritic spine synapse numbers in hippocampus (CA1, CA3, dentate gyrus) and prefrontal cortex (Walker area 46) will be studied at 4 years of age, one year after termination of ..
  61. REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS
    Irwin Lucki; Fiscal Year: 2013
    ..Evidence for increases of neurogenesis in the adult dentate gyrus of the hippocampus is a model for changes in neuroplasticity that emerge with chronic treatment with ..
  62. Volatile anesthetic alteration of neural precursor cell cycle and fate decisions
    Jeffrey W Sall; Fiscal Year: 2013
    ..Neurogenesis in the hippocampal dentate gyrus is necessary for certain types of learning and memory...
  63. REGULATION OF HIPPOCAMPAL NEUROGENESIS BY ANTIDEPRESSANTS
    Irwin Lucki; Fiscal Year: 2009
    ..Evidence for increases of neurogenesis in the adult dentate gyrus of the hippocampus are a model for changes in neuroplasticity that emerge with chronic treatment with ..
  64. MECHANISMS UNDERLYING ADRENAL STEROID MODULATION OF LTP
    Constantine Pavlides; Fiscal Year: 2000
    ..of adrenal steroid receptors, mineralocorticoid (MR) and glucocorticoid (GR), produce opposite effects in th dentate gyrus (DG) and CA1 hippocampal field-MR activation enhances while GR activation suppresses LTP...
  65. Connexins in Ischemia-Induced Neuronal Death
    Michael Bennett; Fiscal Year: 2007
    ..Pyramidal cells in CA1 are the most sensitive; CA3 and granule cells of the dentate gyrus (DG) are resistant to ischemic damage, and GABAergic interneurons in CA1 also survive...
  66. ENDOGENOUS DYNORPHIN OPIOIDS AND TEMPORAL LOBE EPILEPSY
    Charles Chavkin; Fiscal Year: 1999
    ..animal models of temporal lobe epilepsy, there is often an expansion of the dynorphin-containing fibers in the dentate gyrus as a consequence of synaptic reorganization...
  67. RAT MODEL OF FETAL ALCOHOL SYNDROME
    ASA BLACK; Fiscal Year: 1993
    ..neurons in the medial septal nucleus and nucleus of the diagonal band synapse on pyramidal cells and dentate gyrus cells...
  68. PLASTICITY OF GABAERGIC INHIBITION FOLLOWING HEAD INJURY
    Ivan Soltesz; Fiscal Year: 2001
    ..However, the mechanisms by which head injury gives rise to epilepsy are poorly understood. The dentate gyrus of the hippocampal formation plays a central role in the regulation of excitability in the epilepsy-prone ..
  69. ETHANOL AFFECTS HYPOTHALAMIC-DENTATE GYRUS INTERACTIONS
    MATTHEW WAYNER; Fiscal Year: 2001
    ..These LHA circuits have embedded within them angiotensin (Ang) neurons that release Ang onto dentate gyrus granule cells and modulate synaptic plasticity in this brain region which plays an important role in learning ..
  70. Cannabinoid modulation of epileptiform activity in mice
    Bret Smith; Fiscal Year: 2006
    ..R21) research proposal is to identify the effects of exogenous and endogenous cannabinoids on neurons of the dentate gyrus in mice with pilocarpine-induced temporal lobe epilepsy (TLE), characterized by chronic spontaneous seizures, ..
  71. TREATMENT OF TRAUMATIC BRAIN INJURY WITH SIMVASTATIN
    Asim Mahmood; Fiscal Year: 2009
    ..Neurogenesis in the ipsilateral dentate gyrus will be evaluated (Specific Aim 1)...
  72. PHYSIOLOGY AND PHARMACOLOGY OF OPIOIDS IN BRAIN
    EDWARD FRENCH; Fiscal Year: 2001
    ..defined mu-, delta- and kappa-opioid receptor subtypes, as modulators of synaptic transmission in the CA1 and dentate gyrus regions of the hippocampus, and in another brain region known as the periaqueductal gray...
  73. P I/II Intraventricular DepoCyt (OD # 06-2348) in Glioblastoma (76,730, 11/06)
    BRUCE MICHAEL FRANKEL; Fiscal Year: 2010
    ..persisting in the adult mammalian brain, lining the lateral ventricles in the subventricular zone (SVZ) and dentate gyrus, play a role in gliomagenesis...
  74. Ectopic Granule Cells in Epilepsy
    J Victor Nadler; Fiscal Year: 2010
    This project concerns the role of ectopic dentate granule cells in temporal lobe epilepsy. The dentate gyrus is believed to act as a gatekeeper or filter to inhibit the propagation of synchronized discharge through the limbic circuit...