hippocampus

Summary

Summary: A curved elevation of gray matter extending the entire length of the floor of the temporal horn of the lateral ventricle (Dorland, 28th ed). The hippocampus, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.

Top Publications

  1. ncbi Memory--a century of consolidation
    J L McGaugh
    the Center for the Neurobiology of Learning and Memory and the Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA
    Science 287:248-51. 2000
  2. ncbi The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
  3. pmc Are the dorsal and ventral hippocampus functionally distinct structures?
    Michael S Fanselow
    Department of Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuron 65:7-19. 2010
  4. ncbi Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    Dominic M Walsh
    Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 416:535-9. 2002
  5. pmc HDAC2 negatively regulates memory formation and synaptic plasticity
    Ji Song Guan
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences
    Nature 459:55-60. 2009
  6. ncbi A brain-specific microRNA regulates dendritic spine development
    Gerhard M Schratt
    Neurobiology Program, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 439:283-9. 2006
  7. pmc Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
  8. pmc Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    Jason S Snyder
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 476:458-61. 2011
  9. pmc Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
    Amanda Sierra
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 7:483-95. 2010
  10. ncbi Genome-wide atlas of gene expression in the adult mouse brain
    Ed S Lein
    Allen Institute for Brain Science, Seattle, Washington 98103, USA
    Nature 445:168-76. 2007

Research Grants

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
  2. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
  3. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
  4. Jonathan Savitz; Fiscal Year: 2016
  5. Susan Carnell; Fiscal Year: 2015
  6. Alan Frazer; Fiscal Year: 2016
  7. Schahram Akbarian; Fiscal Year: 2014
  8. Laura L Dugan; Fiscal Year: 2014
  9. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
  10. David E Clapham; Fiscal Year: 2014

Detail Information

Publications516 found, 100 shown here

  1. ncbi Memory--a century of consolidation
    J L McGaugh
    the Center for the Neurobiology of Learning and Memory and the Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA
    Science 287:248-51. 2000
    ..This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories...
  2. ncbi The molecular biology of memory storage: a dialogue between genes and synapses
    E R Kandel
    Howard Hughes Medical Institute, Center for Neurobiology and Behavior, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA
    Science 294:1030-8. 2001
    ....
  3. pmc Are the dorsal and ventral hippocampus functionally distinct structures?
    Michael S Fanselow
    Department of Psychology and the Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095 1563, USA
    Neuron 65:7-19. 2010
    One literature treats the hippocampus as a purely cognitive structure involved in memory; another treats it as a regulator of emotion whose dysfunction leads to psychopathology...
  4. ncbi Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    Dominic M Walsh
    Department of Neurology, Harvard Medical School and Center for Neurologic Diseases, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nature 416:535-9. 2002
    ....
  5. pmc HDAC2 negatively regulates memory formation and synaptic plasticity
    Ji Song Guan
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences
    Nature 459:55-60. 2009
    ..These observations encourage the development and testing of HDAC2-selective inhibitors for human diseases associated with memory impairment...
  6. ncbi A brain-specific microRNA regulates dendritic spine development
    Gerhard M Schratt
    Neurobiology Program, Children s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 439:283-9. 2006
    ..Exposure of neurons to extracellular stimuli such as brain-derived neurotrophic factor relieves miR-134 inhibition of Limk1 translation and in this way may contribute to synaptic development, maturation and/or plasticity...
  7. pmc Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations
    Thomas Klausberger
    MRC Anatomical Neuropharmacology Unit, Oxford University, Oxford OX1 3TH, UK
    Science 321:53-7. 2008
    ..The spatiotemporal specializations in cortical circuits reveal that cellular diversity and temporal dynamics coemerged during evolution, providing a basis for cognitive behavior...
  8. pmc Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
    Jason S Snyder
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nature 476:458-61. 2011
    ..In the hippocampus, a brain region densely populated with receptors for stress hormones, stress and glucocorticoids strongly ..
  9. pmc Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
    Amanda Sierra
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell Stem Cell 7:483-95. 2010
    In the adult hippocampus, neuroprogenitor cells in the subgranular zone (SGZ) of the dentate gyrus give rise to newborn neuroblasts...
  10. ncbi Genome-wide atlas of gene expression in the adult mouse brain
    Ed S Lein
    Allen Institute for Brain Science, Seattle, Washington 98103, USA
    Nature 445:168-76. 2007
    ..This highly standardized atlas provides an open, primary data resource for a wide variety of further studies concerning brain organization and function...
  11. ncbi Pattern separation in the dentate gyrus and CA3 of the hippocampus
    Jill K Leutgeb
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 315:961-6. 2007
    ....
  12. pmc Long-term potentiation depends on release of D-serine from astrocytes
    Christian Henneberger
    UCL Institute of Neurology, University College London, London WC1N 3BG, UK
    Nature 463:232-6. 2010
    ..We therefore demonstrate that Ca(2+)-dependent release of D-serine from an astrocyte controls NMDAR-dependent plasticity in many thousands of excitatory synapses nearby...
  13. ncbi Wnt signalling regulates adult hippocampal neurogenesis
    Dieter Chichung Lie
    Laboratory of Genetics, The Salk Institute, La Jolla, California 92037, USA
    Nature 437:1370-5. 2005
    ..Our data show that Wnt signalling is a principal regulator of adult hippocampal neurogenesis and provide evidence that Wnt proteins have a role in adult hippocampal function...
  14. ncbi A synaptic model of memory: long-term potentiation in the hippocampus
    T V Bliss
    Division of Neurophysiology and Neuropharmacology, National Institute of Medical Research, Mill Hill, London, UK
    Nature 361:31-9. 1993
    Long-term potentiation of synaptic transmission in the hippocampus is the primary experimental model for investigating the synaptic basis of learning and memory in vertebrates...
  15. ncbi The medial temporal lobe
    Larry R Squire
    Veterans Affairs Healthcare System, San Diego, California 92161, USA
    Annu Rev Neurosci 27:279-306. 2004
    ..However, the available data do not support simple dichotomies between the functions of the hippocampus and the adjacent medial temporal cortex, such as associative versus nonassociative memory, episodic versus ..
  16. pmc Tau suppression in a neurodegenerative mouse model improves memory function
    K SantaCruz
    Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Science 309:476-81. 2005
    ..Thus, NFTs are not sufficient to cause cognitive decline or neuronal death in this model of tauopathy...
  17. doi Altered histone acetylation is associated with age-dependent memory impairment in mice
    Shahaf Peleg
    Laboratory for Aging and Cognitive Diseases, European Neuroscience Institute, Grisebach Str 5, D 37077 Goettingen, Germany
    Science 328:753-6. 2010
    ..Our data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the aging mouse brain...
  18. pmc Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
    Amar Sahay
    Department of Neuroscience, Columbia University, New York, New York 10032, USA
    Nature 472:466-70. 2011
    ....
  19. pmc Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
    Toshiaki Nakashiba
    Department of Biology, RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 149:188-201. 2012
    ..Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion...
  20. pmc microRNA-132 regulates dendritic growth and arborization of newborn neurons in the adult hippocampus
    Stephen T Magill
    Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA
    Proc Natl Acad Sci U S A 107:20382-7. 2010
    Newborn neurons in the dentate gyrus of the adult hippocampus rely upon cAMP response element binding protein (CREB) signaling for their differentiation into mature granule cells and their integration into the dentate network...
  21. ncbi Learning induces long-term potentiation in the hippocampus
    Jonathan R Whitlock
    Howard Hughes Medical Institute, Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 313:1093-7. 2006
    ..Because the learning-induced synaptic potentiation occluded HFS-induced LTP, we conclude that inhibitory avoidance training induces LTP in CA1...
  22. pmc Pattern separation: a common function for new neurons in hippocampus and olfactory bulb
    Amar Sahay
    Departments of Neuroscience and Psychiatry, Columbia University, New York, USA
    Neuron 70:582-8. 2011
    While adult-born neurons in the olfactory bulb (OB) and the dentate gyrus (DG) subregion of the hippocampus have fundamentally different properties, they may have more in common than meets the eye...
  23. ncbi Multimodal fast optical interrogation of neural circuitry
    Feng Zhang
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 446:633-9. 2007
    ..NpHR and ChR2 form a complete system for multimodal, high-speed, genetically targeted, all-optical interrogation of living neural circuits...
  24. pmc Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
    Hsiao Tuan Chao
    Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 468:263-9. 2010
    ..These data demonstrate that MeCP2 is critical for normal function of GABA-releasing neurons and that subtle dysfunction of GABAergic neurons contributes to numerous neuropsychiatric phenotypes...
  25. ncbi Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
    Eric A Bushong
    National Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093 0608, USA
    J Neurosci 22:183-92. 2002
    ....
  26. ncbi Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images
    E Meijering
    Department of Medical Informatics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Cytometry A 58:167-76. 2004
    ..To facilitate this task, we developed a semiautomatic neurite tracing technique. This article describes the design and validation of the technique...
  27. ncbi The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation
    C Rivera
    Department of Biosciences, University of Helsinki, Finland
    Nature 397:251-5. 1999
    ..Here we show that, in pyramidal neurons of the rat hippocampus, the ontogenetic change in GABA(A)-mediated responses from depolarizing to hyperpolarizing is coupled to a ..
  28. pmc Neurogenesis-dependent and -independent effects of fluoxetine in an animal model of anxiety/depression
    Denis J David
    Université Paris Sud EA 3544, Faculte de Pharmacie, Chatenay Malabry Cedex F 92296, France
    Neuron 62:479-93. 2009
    ..Importantly, mice deficient in one of these genes, beta-arrestin 2, displayed a reduced response to fluoxetine in multiple tasks, suggesting that beta-arrestin signaling is necessary for the antidepressant effects of fluoxetine...
  29. pmc In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
    Michael A Bonaguidi
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Cell 145:1142-55. 2011
    ..self-renewal but ultimately leads to terminal astrocytic differentiation and RGL depletion in the adult hippocampus. Our study identifies RGLs as self-renewing and multipotent neural stem cells and provides novel insights into ..
  30. ncbi Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
    Nadia M Tsankova
    The University of Texas Southwestern Medical Center, Department of Psychiatry and Center for Basic Neuroscience, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9070, USA
    Nat Neurosci 9:519-25. 2006
    ..of five brain-derived neurotrophic factor (Bdnf) splice variant mRNAs (I-V) and their unique promoters in the hippocampus. Defeat stress induced lasting downregulation of Bdnf transcripts III and IV and robustly increased repressive ..
  31. pmc An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP
    Gary A Wayman
    Department of Veterinary Anatomy, Physiology, and Pharmacology, Washington State University, 100 Dairy Road, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 105:9093-8. 2008
    ..Experiments using dominant-interfering mutants suggested that Rac signaling is downstream of miR132 and p250GAP. We propose that the miR132-p250GAP pathway plays a key role in activity-dependent structural and functional plasticity...
  32. ncbi Milestones of neuronal development in the adult hippocampus
    Gerd Kempermann
    VolkswagenStiftung Research Group, Department of Experimental Neurology, Charite University Medicine Berlin, Schumannstrasse 20 21, 10117 Berlin, Germany
    Trends Neurosci 27:447-52. 2004
    ..The selection process, during which new neurons are recruited into function, and other regulatory influences differentially affect the different stages of development...
  33. pmc The medial temporal lobe and recognition memory
    H Eichenbaum
    Center for Memory and Brain, Boston University, Boston, Massachusetts 02215, USA
    Annu Rev Neurosci 30:123-52. 2007
    ..The data suggest that the hippocampus is critical for recollection but not familiarity...
  34. doi hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations
    Kohji Mori
    Adolf Butenandt Institute, Biochemistry, Ludwig Maximilians University, Schillerstr 44, 80336, Munich, Germany
    Acta Neuropathol 125:413-23. 2013
    ..This revealed that hnRNP A3 formed neuronal cytoplasmic and intranuclear inclusions in the hippocampus of patients with C9orf72 repeat extensions...
  35. ncbi Synaptic scaling mediated by glial TNF-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304 5485, USA
    Nature 440:1054-9. 2006
    ..We suggest that by modulating TNF-alpha levels, glia actively participate in the homeostatic activity-dependent regulation of synaptic connectivity...
  36. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..The extensive recurrent connectivity of the CA3 area of hippocampus has led to suggestions that it might provide this function...
  37. ncbi Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    Pascale N Lacor
    Neurobiology and Physiology Department, Northwestern University, Evanston, Illinois 60208, USA5
    J Neurosci 24:10191-200. 2004
    ..Results suggest the hypothesis that targeting and functional disruption of particular synapses by Abeta oligomers may provide a molecular basis for the specific loss of memory function in early AD...
  38. pmc Mechanisms of CaMKII action in long-term potentiation
    John Lisman
    Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA
    Nat Rev Neurosci 13:169-82. 2012
    ..These processes are all localized to stimulated spines and account for the synapse-specificity of LTP. In the later stages of LTP, CaMKII has a structural role in enlarging and strengthening the synapse...
  39. pmc Pattern separation in the hippocampus
    Michael A Yassa
    Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21218, USA
    Trends Neurosci 34:515-25. 2011
    ..This ability has long been hypothesized to require the hippocampus, and computational models suggest that it is dependent on pattern separation...
  40. ncbi Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
    Luca Santarelli
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Science 301:805-9. 2003
    ..X-irradiation of a restricted region of mouse brain containing the hippocampus prevented the neurogenic and behavioral effects of two classes of antidepressants...
  41. ncbi Memory of sequential experience in the hippocampus during slow wave sleep
    Albert K Lee
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 36:1183-94. 2002
    ..This rapid encoding of sequential experience is consistent with evidence that the hippocampus is crucial for spatial learning in rodents and the formation of long-term memories of events in time in humans.
  42. ncbi Reverse replay of behavioural sequences in hippocampal place cells during the awake state
    David J Foster
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, 46 5223, Cambridge, Massachusetts 02139, USA
    Nature 440:680-3. 2006
    The hippocampus has long been known to be involved in spatial navigational learning in rodents, and in memory for events in rodents, primates and humans...
  43. ncbi Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    Forming distinct representations of multiple contexts, places, and episodes is a crucial function of the hippocampus. The dentate gyrus subregion has been suggested to fulfill this role...
  44. pmc A functional screen implicates microRNA-138-dependent regulation of the depalmitoylation enzyme APT1 in dendritic spine morphogenesis
    Gabriele Siegel
    Interdisziplinäres Zentrum für Neurowissenschaften, SFB488 Junior Group, Universitat Heidelberg, and Institut für Neuroanatomie, Universitatsklinikum Heidelberg, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany
    Nat Cell Biol 11:705-16. 2009
    ..Our results uncover a previously unknown miRNA-dependent mechanism in neurons and demonstrate a previously unrecognized complexity of miRNA-dependent control of dendritic spine morphogenesis...
  45. ncbi Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
    Manuela Neumann
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 314:130-3. 2006
    ..to generate C-terminal fragments and was recovered only from affected central nervous system regions, including hippocampus, neocortex, and spinal cord...
  46. ncbi Vascular niche for adult hippocampal neurogenesis
    T D Palmer
    Stanford University, Department of Neurosurgery, Palo Alto, California 94305, USA
    J Comp Neurol 425:479-94. 2000
    ..hilus and granule cell layer, or subgranule zone (SGZ), is an area of active proliferation within the adult hippocampus known to generate new neurons throughout adult life...
  47. pmc Exercise enhances learning and hippocampal neurogenesis in aged mice
    Henriette van Praag
    Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 25:8680-5. 2005
    Aging causes changes in the hippocampus that may lead to cognitive decline in older adults. In young animals, exercise increases hippocampal neurogenesis and improves learning...
  48. ncbi Path integration and the neural basis of the 'cognitive map'
    Bruce L McNaughton
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, and Department of Psychology, University of Arizona, Tucson 85724, USA
    Nat Rev Neurosci 7:663-78. 2006
    ..The scale at which space is represented increases systematically along the dorsoventral axis in both the hippocampus and the MEC, apparently because of systematic variation in the gain of a movement-speed signal...
  49. doi Frequency of gamma oscillations routes flow of information in the hippocampus
    Laura Lee Colgin
    Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, MTFS, Olav Kyrres gate 9, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Nature 462:353-7. 2009
    ..Here we show that gamma oscillations in the CA1 area of the hippocampus split into distinct fast and slow frequency components that differentially couple CA1 to inputs from the medial ..
  50. pmc Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
    Matthew Suderman
    Sackler Program for Epigenetics and Developmental Psychobiology at McGill University, Department of Pharmacology and Therapeutics, McGill University, Montreal, QC, Canada
    Proc Natl Acad Sci U S A 109:17266-72. 2012
    ..long-term effects on behavior and epigenetic programming of the NR3C1 (GLUCOCORTICOID RECEPTOR) gene in the hippocampus of both rats and humans...
  51. pmc Neocortical excitation/inhibition balance in information processing and social dysfunction
    Ofer Yizhar
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nature 477:171-8. 2011
    ..These results provide support for the elevated cellular E/I balance hypothesis of severe neuropsychiatric disease-related symptoms...
  52. pmc Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132
    Dieter Edbauer
    The Picower Institute for Learning and Memory, Departments of Brain and Cognitive Sciences and Biology, Massachusetts Institute of Technology, Cambridge, MA 02319, USA
    Neuron 65:373-84. 2010
    ..Because NMDA receptor subunit composition profoundly affects synaptic plasticity, these observations have implications for the pathophysiology of fragile X syndrome, in which plasticity is altered...
  53. pmc Astrocyte-neuron lactate transport is required for long-term memory formation
    Akinobu Suzuki
    Department of Neuroscience, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cell 144:810-23. 2011
    We report that, in the rat hippocampus, learning leads to a significant increase in extracellular lactate levels that derive from glycogen, an energy reserve selectively localized in astrocytes...
  54. pmc Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease
    Mark Kilgore
    Department of Neurobiology, Evelyn F McKnight Brain Institute, University of Alabama at Birmingham School of Medicine, Birmingham, AL 35294, USA
    Neuropsychopharmacology 35:870-80. 2010
    ..These preclinical results indicate that targeted inhibition of class I HDAC isoforms is a promising avenue for treating the cognitive deficits associated with early stage AD...
  55. pmc Inflammation is detrimental for neurogenesis in adult brain
    Christine T Ekdahl
    Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Biomedical Center A 11, Lund, Sweden
    Proc Natl Acad Sci U S A 100:13632-7. 2003
    ..Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation...
  56. ncbi Control of synaptic strength by glial TNFalpha
    Eric C Beattie
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA 94304, USA
    Science 295:2282-5. 2002
    ..Through its effects on AMPA receptor trafficking, TNFalpha may play roles in synaptic plasticity and modulating responses to neural injury...
  57. pmc Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, MA 02454, USA
    Trends Neurosci 31:234-42. 2008
    ..Overactive pyramidal cells, notably those in the hippocampus, can drive a hyperdopaminergic state that produces psychosis...
  58. ncbi Distinct morphological stages of dentate granule neuron maturation in the adult mouse hippocampus
    Chunmei Zhao
    Laboratory of Genetics, Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 26:3-11. 2006
    Adult neurogenesis in the dentate gyrus may contribute to hippocampus-dependent functions, yet little is known about when and how newborn neurons are functional because of limited information about the time course of their connectivity...
  59. ncbi Inflammatory blockade restores adult hippocampal neurogenesis
    Michelle L Monje
    Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305 5487, USA
    Science 302:1760-5. 2003
    ....
  60. ncbi Astrocytic purinergic signaling coordinates synaptic networks
    Olivier Pascual
    Department of Neuroscience, Conte Center for Integration at the Tripartite Synapse, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 310:113-6. 2005
    ..These results indicate that astrocytes are intricately linked in the regulation of synaptic strength and plasticity and provide a pathway for synaptic cross-talk...
  61. doi GABAergic hub neurons orchestrate synchrony in developing hippocampal networks
    P Bonifazi
    Institut de Neurobiologie de la Méditerranée INSERM U901, Universitéde la Méditerranée, Parc Scientifique de Luminy, Boite Postale 13, 13273 Marseille Cedex 9, France
    Science 326:1419-24. 2009
    ..These findings establish a central role for GABAergic interneurons in shaping developing networks and help provide a conceptual framework for studying neuronal synchrony...
  62. pmc The parietal cortex and episodic memory: an attentional account
    Roberto Cabeza
    Center for Cognitive Neuroscience, Duke University, B203 LSRC Building, Durham, North Carolina 27708, USA
    Nat Rev Neurosci 9:613-25. 2008
    ....
  63. doi Local Ca2+ detection and modulation of synaptic release by astrocytes
    Maria Amalia Di Castro
    Department of Cell Biology and Morphology, University of Lausanne, Lausanne, Switzerland
    Nat Neurosci 14:1276-84. 2011
    ..two-photon microscopy, we identify the characteristics of local astrocyte calcium activity in the adult mouse hippocampus. Astrocytic processes showed intense activity, triggered by physiological transmission at neighboring synapses...
  64. ncbi Memory consolidation, retrograde amnesia and the hippocampal complex
    L Nadel
    Department of Psychology and Neural Systems, Memory and Aging Division, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Neurobiol 7:217-27. 1997
    ..g. autobiographical episodic and spatial memory) for as long as they exist and contribute to the transformation and stabilization of other forms of memory stored elsewhere in the brain...
  65. pmc Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
    Erik D Roberson
    Gladstone Institute of Neurological Disease, San Francisco, California 94158, USA
    J Neurosci 31:700-11. 2011
    ..Our results indicate that Aβ, tau, and Fyn jointly impair synaptic and network function and suggest that disrupting the copathogenic relationship between these factors could be of therapeutic benefit...
  66. ncbi Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
    Qiang Zhou
    Division of Neurobiology, Department of Molecular and Cell Biology, Helen Will Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Neuron 44:749-57. 2004
    ..This activity-induced spine shrinkage may contribute to activity-dependent elimination of synaptic connections...
  67. pmc Exercise training increases size of hippocampus and improves memory
    Kirk I Erickson
    Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Proc Natl Acad Sci U S A 108:3017-22. 2011
    The hippocampus shrinks in late adulthood, leading to impaired memory and increased risk for dementia...
  68. ncbi Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
    Radoslaw Rola
    Brain Tumor Research Center, Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Exp Neurol 188:316-30. 2004
    ..The pathogenesis of these deficits remains unknown, but may involve reduced neurogenesis within the hippocampus. To determine the acute radiosensitivity of the dentate subgranular zone (SGZ), 21-day-old C57BL/J6 male mice ..
  69. pmc Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
    Jia Yao
    Department of Pharmacology and Pharmaceutical Sciences and Program in Neuroscience, Pharmaceutical Sciences Center, University of Southern California, Los Angeles, CA 90033, USA
    Proc Natl Acad Sci U S A 106:14670-5. 2009
    ..Embryonic neurons derived from 3xTg-AD mouse hippocampus exhibited significantly decreased mitochondrial respiration and increased glycolysis...
  70. doi The mood-improving actions of antidepressants do not depend on neurogenesis but are associated with neuronal remodeling
    J M Bessa
    Life and Health Science Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Mol Psychiatry 14:764-73, 739. 2009
    ..of, and the recovery from, depression are still largely unknown; views that neurogenesis in the hippocampus may be important for the pathogenesis and amelioration of depressive symptoms have gained currency over the ..
  71. ncbi Culturing hippocampal neurons
    Stefanie Kaech
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, L606, 3181 SW Sam Jackson Park Rd, Portland, Oregon 97239, USA
    Nat Protoc 1:2406-15. 2006
    ..Preparation of glial feeder cultures must begin 2 weeks in advance, and it takes 5 d to prepare coverslips as a substrate for neuronal growth. Dissecting the hippocampus and plating hippocampal neurons takes 2-3 h.
  72. pmc Propagation of tau pathology in a model of early Alzheimer's disease
    Alix de Calignon
    MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Alzheimer s Disease Research Laboratory, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuron 73:685-97. 2012
    ..by propagation to neurons downstream in the synaptic circuit such as the dentate gyrus, CA fields of the hippocampus, and cingulate cortex. Human tau protein spreads to these regions and coaggregates with endogenous mouse tau...
  73. pmc DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212
    Ju Young Kim
    Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Neuron 63:761-73. 2009
    ..Here, we show that DISC1 suppression in newborn neurons of the adult hippocampus leads to overactivated signaling of AKT, another schizophrenia susceptibility gene...
  74. pmc Incipient Alzheimer's disease: microarray correlation analyses reveal major transcriptional and tumor suppressor responses
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, Spinal Cord and Brain Injury Research Center, and Sanders Brown Research Center on Aging, University of Kentucky College of Medicine, Lexington, KY 40536, USA
    Proc Natl Acad Sci U S A 101:2173-8. 2004
    ..These findings suggest a new model of AD pathogenesis in which a genomically orchestrated up-regulation of tumor suppressor-mediated differentiation and involution processes induces the spread of pathology along myelinated axons...
  75. ncbi Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease
    Gorazd B Stokin
    Howard Hughes Medical Institute and Department of Cellular and Molecular Medicine, School of Medicine, University of California San Diego UCSD, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Science 307:1282-8. 2005
    ..Reductions in microtubule-dependent transport may stimulate proteolytic processing of beta-amyloid precursor protein, resulting in the development of senile plaques and Alzheimer's disease...
  76. pmc Patients with hippocampal amnesia cannot imagine new experiences
    Demis Hassabis
    Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, 12 Queen Square, London WC1N 3BG, United Kingdom
    Proc Natl Acad Sci U S A 104:1726-31. 2007
    ..We tested whether a group of amnesic patients with primary damage to the hippocampus bilaterally could construct new imagined experiences in response to short verbal cues that outlined a range of ..
  77. doi MicroRNA loss enhances learning and memory in mice
    Witold Konopka
    Molecular Biology of the Cell I, German Cancer Research Center, D 69120 Heidelberg, Germany
    J Neurosci 30:14835-42. 2010
    ..The presented work shows miRNAs as key players in the learning and memory process of mammals...
  78. ncbi The hippocampal-VTA loop: controlling the entry of information into long-term memory
    John E Lisman
    Department of Biology, Brandeis University, 415 South Street, Waltham, Massachusetts 02454, USA
    Neuron 46:703-13. 2005
    In this article we develop the concept that the hippocampus and the midbrain dopaminergic neurons of the ventral tegmental area (VTA) form a functional loop...
  79. pmc Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
    Ganesh M Shankar
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Med 14:837-42. 2008
    ..potentiation (LTP), enhanced long-term depression (LTD) and reduced dendritic spine density in normal rodent hippocampus. Soluble Abeta from Alzheimer's disease brain also disrupted the memory of a learned behavior in normal rats...
  80. ncbi Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons
    Ajai Vyas
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    J Neurosci 22:6810-8. 2002
    The hippocampus and the amygdala are essential components of the neural circuitry mediating stress responses...
  81. ncbi LTP inhibits LTD in the hippocampus via regulation of GSK3beta
    Stephane Peineau
    MRC Centre for Synaptic Plasticity, Department of Anatomy, School of Medical Sciences, University Walk, Bristol, BS8 1TD, United Kingdom
    Neuron 53:703-17. 2007
    ..We conclude that the regulation of GSK3beta activity provides a powerful mechanism to preserve information encoded during LTP from erasure by subsequent LTD, perhaps thereby permitting the initial consolidation of learnt information...
  82. doi NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory
    Tatiana Korotkova
    Department of Clinical Neurobiology, IZN, Im Neuenheimer Feld 364, 69120 Heidelberg, Germany
    Neuron 68:557-69. 2010
    ..Finally, NR1(PVCre-/-) mice exhibited impaired spatial working as well as spatial short- and long-term recognition memory but showed no deficits in open field exploratory activity and spatial reference learning...
  83. pmc Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
    Michael D Saxe
    Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 103:17501-6. 2006
    ..Specifically, focal X irradiation of the hippocampus or genetic ablation of glial fibrillary acidic protein-positive neural progenitor cells impaired contextual ..
  84. pmc Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration
    Ming Jin
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 108:5819-24. 2011
    ..We conclude that natural dimers isolated from the AD brain are sufficient to potently induce AD-type tau phosphorylation and then neuritic dystrophy, but passive immunotherapy mitigates this...
  85. ncbi The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory
    J Z Tsien
    Howard Hughes Medical Institute, Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge 02139, USA
    Cell 87:1327-38. 1996
    ..a mouse strain in which the deletion of the NMDAR1 gene is restricted to the CA1 pyramidal cells of the hippocampus by using a new and general method that allows CA1-restricted gene knockout...
  86. ncbi Transient expression of doublecortin during adult neurogenesis
    Jason P Brown
    Department of Neurology, University of Regensburg, 93053 Regensburg, Germany
    J Comp Neurol 467:1-10. 2003
    ..This assumption is further supported by our observation that the number of DCX-expressing cells in the dentate gyrus was decreased with age according to the reduction of neurogenesis in the aging dentate gyrus previously reported...
  87. ncbi Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha
    David Stellwagen
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford Medical School, Palo Alto, California 94305, USA
    J Neurosci 25:3219-28. 2005
    ..These results suggest that TNFalpha can regulate neuronal circuit homeostasis in a manner that may exacerbate excitotoxic damage resulting from neuronal insults...
  88. ncbi Dynamics of the hippocampus during encoding and retrieval of face-name pairs
    Michael M Zeineh
    Ahmanson Lovelace Brain Mapping Center, UCLA School of Medicine, 660 Charles Young Drive South, Los Angeles, CA 90095 7085, USA
    Science 299:577-80. 2003
    ..Activity in the subiculum showed the same temporal decline, but primarily during retrieval. Our results demonstrate that subdivisions within the hippocampus make distinct contributions to new memory formation.
  89. ncbi Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    Pascale N Lacor
    Department of Neurobiology and Physiology, Northwestern University, Evanston, Illinois 60208, USA
    J Neurosci 27:796-807. 2007
    ..The observed disruption of dendritic spines links ADDLs to a major facet of AD pathology, providing strong evidence that ADDLs in AD brain cause neuropil damage believed to underlie dementia...
  90. ncbi Kinesin transports RNA: isolation and characterization of an RNA-transporting granule
    Yoshimitsu Kanai
    Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuron 43:513-25. 2004
    ..Thus, kinesin transports RNA via this granule in dendrites coordinately with opposite motors, such as dynein...
  91. ncbi Hippocampal remapping and grid realignment in entorhinal cortex
    Marianne Fyhn
    Centre for the Biology of Memory, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Nature 446:190-4. 2007
    ..In the hippocampus, this neuronal pattern separation is expressed as the tendency of ensembles of place cells to undergo extensive ..
  92. pmc Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
    Zheng Li
    The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 141:859-71. 2010
    ..NMDA receptor stimulation that induces LTD transiently activates caspase-3 in dendrites, without causing cell death. These data indicate an unexpected causal link between the molecular mechanisms of apoptosis and LTD...
  93. ncbi Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    Ian C G Weaver
    Douglas Hospital Research Center, Montreal, Quebec H4H 1R3, Canada
    J Neurosci 25:11045-54. 2005
    ..These results demonstrate that, despite the inherent stability of the epigenomic marks established early in life through behavioral programming, they are potentially reversible in the adult brain...
  94. ncbi Enforcement of temporal fidelity in pyramidal cells by somatic feed-forward inhibition
    F Pouille
    Brain Research Institute, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
    Science 293:1159-63. 2001
    ..Thus, the subcellular partitioning of feed-forward inhibition enforces precise coincidence detection in the soma, while allowing dendrites to sum incoming activity over broader time windows...
  95. ncbi Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval
    Thomas Seidenbecher
    Institut fur Physiologie, Otto von Guericke Universitat, Leipziger Strasse 44, Magdeburg D 39120, Germany
    Science 301:846-50. 2003
    ..We simultaneously recorded electrical activity in the lateral amygdala (LA) and the CA1 area of the hippocampus in freely behaving fear-conditioned mice...
  96. doi Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
    Paul A Adlard
    Oxidation Biology Laboratory, The Mental Health Research Institute of Victoria, Parkville, Victoria 3052, Australia
    Neuron 59:43-55. 2008
    ..The speed of recovery of the animals underscores the acutely reversible nature of the cognitive deficits associated with transgenic models of AD...
  97. pmc Division-coupled astrocytic differentiation and age-related depletion of neural stem cells in the adult hippocampus
    Juan M Encinas
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Cell Stem Cell 8:566-79. 2011
    Production of new neurons in the adult hippocampus decreases with age; this decline may underlie age-related cognitive impairment...
  98. ncbi CB1 cannabinoid receptors and on-demand defense against excitotoxicity
    Giovanni Marsicano
    Molecular Genetics of Behaviour, Max Planck Institute of Psychiatry, Kraepelinstrabetae 2 10, 80804 Munich, Germany
    Science 302:84-8. 2003
    ..These protective mechanisms could not be triggered in mutant mice. The endogenous cannabinoid system thus provides on-demand protection against acute excitotoxicity in central nervous system neurons...
  99. ncbi A role for adult neurogenesis in spatial long-term memory
    J S Snyder
    Department of Physiology, University of Toronto, 1 King s College Circle, Room 3214, Toronto, Ontario, Canada M5S 1A8
    Neuroscience 130:843-52. 2005
    ..These results suggest a new role for adult neurogenesis in the formation and/or consolidation of long-term, hippocampus-dependent, spatial memories.
  100. pmc Boundary vector cells in the subiculum of the hippocampal formation
    Colin Lever
    Behavioural Neuroscience Laboratory, Institute of Psychological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Neurosci 29:9771-7. 2009
    ..These cells may contribute environmental information to place cell firing, complementing path integrative information. Their relationship to other cell types, including medial entorhinal "border cells," is discussed...
  101. ncbi Stress and hippocampal plasticity
    B S McEwen
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, Rockefeller University, New York, New York 10021, USA
    Annu Rev Neurosci 22:105-22. 1999
    The hippocampus is a target of stress hormones, and it is an especially plastic and vulnerable region of the brain...

Research Grants119 found, 100 shown here

  1. Understanding/ Treating Neuropsychiatric Symptoms of Pediatric Physical Illness
    Eva Szigethy; Fiscal Year: 2009
    ..abstract_text> ..
  2. Brain Activation responses in adolescents with genetic predisposition to obesity
    Susan Carnell; Fiscal Year: 2011
    ..Ss are expected to show greater activation relative to lean Ss in the insula, orbitofrontal cortex, amygdala, hippocampus, and striatum (appetitive reward), and less activation in the dorsolateral prefrontal cortex (inhibition of ..
  3. Tyrosine Availability Influences Mesocortico-Limbic Catecholamines
    GEORGE EUGENE JASKIW; Fiscal Year: 2012
    ..We will examine the prefrontal cortex, the striatum, the nucleus accumbens and hippocampus, regions implicated in schizophrenia...
  4. Jonathan Savitz; Fiscal Year: 2016
    ..three neurophysiological correlates of MDD: (a) the abnormal pattern of hemodynamic response in the amygdala, hippocampus, and perigenual ACC to emotionally-valenced faces, (b) reductions in hippocampal volume, and (c) reductions in ..
  5. Susan Carnell; Fiscal Year: 2015
    ..Ss are expected to show greater activation relative to lean Ss in the insula, orbitofrontal cortex, amygdala, hippocampus, and striatum (appetitive reward), and less activation in the dorsolateral prefrontal cortex (inhibition of ..
  6. Alan Frazer; Fiscal Year: 2016
    ..estradiol benzoate (EB) or progesterone (P)), either given systemically or locally into the CA3 region of the hippocampus, interferes with the ability of SSRIs to inhibit the function of what is widely considered their initial ..
  7. Schahram Akbarian; Fiscal Year: 2014
    ..This resulted in decreased levels of the NMDA receptor subunit Grin2b (NR2B) in prefrontal cortex and hippocampus. This finding is interesting because the non-specific NMDA receptor antagonist, ketamine, and the NR2B ..
  8. Laura L Dugan; Fiscal Year: 2014
    ..Inflammatory induction of Nox2 led to a superoxide-dependent loss of subsets of inhibitory interneurons in hippocampus, cortex, and amygdala...
  9. Efficacy of GABAA a5 receptor inverse agonists in learning impaired rats
    EARL MICHAEL GIBBS; Fiscal Year: 2010
    ..GABAA receptor complexes that contain 15 subunits are abundantly expressed in the hippocampus and therefore considered to be a therapeutic target for treating cognitive disorders, like Alzheimer's and ..
  10. David E Clapham; Fiscal Year: 2014
    ..Three subfamily members of this class (TRPC1, TRPC4, and TRPC5) are highly expressed in the hippocampus. These ion channel subunits forms homomeric and heteromeric channels with distinct characteristics...
  11. SAMUEL BRANDON STEPHENS; Fiscal Year: 2015
    ..VGF is expressed in neuroendocrine tissues (hypothalamus, hippocampus), peripheral neurons innervating the gut and adipose, and pancreatic islet cells...
  12. Dopamine's Role in the Rapid Estradiol Enhancement of Excitatory Synapses
    CAROLINE COFER SMITH HAMILTON; Fiscal Year: 2013
    ..from noradrenergic, rather than dopaminergic fibers, is responsible for the observed dopaminergic tone in hippocampus and subsequent dopamine mediated increase in synaptic output...
  13. A Computational Framework for Mapping Long Range Genetic Circuits
    Tolga Tasdizen; Fiscal Year: 2010
    ..to tract tracing, current technology permits only visualization of cells in a single section of a mouse hippocampus but prevents providing answers to the critical questions at the systems level...
  14. CRAIG STEPHEN ATWOOD; Fiscal Year: 2014
    ..follicle-stimulating hormone, E2, pregnenolone (P5), progesterone (P4) and T in matched plasma, CSF and hippocampus from 200 AD and age-matched control brains...
  15. Robert H Eckel; Fiscal Year: 2014
    ..LPL is also present throughout the nervous system including neurons in the hippocampus, hypothalamus, and other brain regions...
  16. Bruce S McEwen; Fiscal Year: 2015
    ..along with resilience conferred by adaptive behaviors, resilience in the form of structural plasticity in the hippocampus and prefrontal cortex is a feature of the healthy brain's response to stress...
  17. Hiv-1 Infection: Central Serotonergic Activity and its Health Implications
    Adarsh M Kumar; Fiscal Year: 2010
    ..activity in the postmortem tissue samples from different brain regions {raphe nuclei, hypothalamus, hippocampus, basal ganglia (caudate nucleus, putamen, globus pallidus), substantia nigra, amygdala and fronto-cortical ..
  18. Design and Synthesis of Anxioselective Anxiolytics
    James M Cook; Fiscal Year: 2010
    ..This is of special importance here in regard to cognition/amnesia and other processes mediated by the hippocampus. A network of 12 collaborators has been established to work with us on receptor binding, efficacy and ..
  19. Ephrin-A3 in Neuron-Glia Communication
    Elena B Pasquale; Fiscal Year: 2011
    ..of neuron-glia communication that involves the ephrin-A3 ligand expressed on the surface of astrocytes in the hippocampus and the EphA4 receptor tyrosine kinase expressed on dendritic spines...
  20. Environmental regulation of estrogen dependent aggression
    Brian C Trainor; Fiscal Year: 2013
    ..appreciation that steroid hormones are synthesized de novo in brain regions such as the hypothalamus and hippocampus. Recent data show estrogen synthesis in the brain is modulated by social interactions on a moment-to- moment ..
  21. E Sherwood Brown; Fiscal Year: 2014
    ..suggests that stress hormones (corticosteroids) are associated with reversible and irreversible changes in the hippocampus, a brain structure that plays a critical role in learning and memory...
  22. Testing the efficacy of PGC-1alpha as a therapeutic target for Parkinson's diseas
    HANS BUELER; Fiscal Year: 2010
    ..and neuronal degeneration and display increased sensitivity to oxidative stressors affecting the SNc and the hippocampus, showing that endogenous PGC-1a protects against oxidative stress in the brain and is physiologically ..
  23. Interacting Impact of Adrenal and Ovarian Aging on the CNS
    Henryk F Urbanski; Fiscal Year: 2011
    ..to aging and prefrontal cortex dysfunction;2) delayed non- matching-to-sample, a task probing primarily hippocampus-based memory;3) a visuospatial cueing test of visual attention that is estrogen-sensitive;and 4) a test of ..
  24. Connexins in Neuronal and Glial Gap Junctions in the Central Nervous System
    John E Rash; Fiscal Year: 2012
    ..circuitry of the mouse brain, to make detailed measurements of "mini" gap junctions in cerebral cortex and hippocampus of both mouse and human brain, and to identify the neuronal subtypes linked by "mini" gap junctions...
  25. Jianxiong Jiang; Fiscal Year: 2014
    ..I will also receive training from Dr. Kerry Ressler for lentiviral-mediated RNA interference in the mouse hippocampus, take courses on advanced neuroscience techniques, research ethics and lab management, and participate in ..
  26. Robert S Fujinami; Fiscal Year: 2016
    ..We propose to test in Specific Aim 1 the hypothesis that direct virus infection of pyramidal cells of the hippocampus leads to the development of seizures...
  27. Neuroendocrine Mechanisms and Therapeutics in an Animal Model of PTSD
    DAVID MARK DIAMOND; Fiscal Year: 2013
    ..Specifically, we will assess the effects of psychosocial stress on BDNF gene methylation in the hippocampus, amygdala and prefrontal cortex...
  28. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..accumbens and globus pallidus, as well as other CB1 and D2 containing regions such as prefrontal cortex and hippocampus. Cerebellum, which expressed CB1 receptors but does not express Gng7, will serve as negative control region...
  29. Michael K Georgieff; Fiscal Year: 2015
    ..Fetal/neonatal ID has particularly profound effects on the developing hippocampus, the brain region responsible for recognition learning and memory...
  30. Carol L Cheatham; Fiscal Year: 2015
    ..Hippocampal slices, blood DNA, and brain DNA will be collected on GD 18 (after cell proliferation in hippocampus), PD 45 (prior to Morris water maze training), and PD 54 (after Morris water maze training)...
  31. Mechanism and Treatment of nerve agent-induced seizures
    Jaideep Kapur; Fiscal Year: 2010
    ..We demonstrate that low doses of paraoxon infused into the hippocampus cause prolonged seizures...
  32. Role of histone acetyltransferases in memory storage and synaptic plasticity
    MARCEL ANDRE ESTEVEZ; Fiscal Year: 2012
    ..to use a targeted approach that would result in a spatially restricted deletion of CBP, p300 or both in the hippocampus, through the use of a viral vector...
  33. Andrea M Allan; Fiscal Year: 2015
    ..The GRs are particularly concentrated in areas of central importance for cognition (hippocampus, amygdala and frontal cortex)...
  34. Mechanisms of Ubiquitin Trafficking in Neurons
    Michael C Wooten; Fiscal Year: 2013
    ..Sequestosome 1/p62 is predominantly expressed in the hippocampus, the center of learning and memory, where it serves as a scaffold to regulate the trafficking of K63-..
  35. Samina Salim; Fiscal Year: 2015
    ..via L-Buthionine-(S,R)-sulfoximine (BSO) treatment reduced RGS2, Glo1 and Gsr1 levels in locus coeruleus (LC), hippocampus and amygdala and increased anxiety-like behavior of rats...
  36. Neuroprotective strategies in seizure-induced damage
    JANA VELISKOVA; Fiscal Year: 2011
    ..is mediated by the NPY and mGluR systems and results in enhanced filtering of incoming seizure activity to the hippocampus leading thus to neuroprotective effects on hilar neurons. Specific aims are to determine: Whether 1A...
  37. PETER A FERRAZZANO; Fiscal Year: 2016
    ..developmental differences in microglial responses to hypoxia-ischemia (HI): early microglia activation in the hippocampus compared to other brain regions, and increased microglial responses in postnatal day 9 (P9) mice compared to ..
  38. BDNF-Estrogen Interactions with Perimenopausal Mood and Cognition
    Elizabeth M Waters; Fiscal Year: 2012
    ..anxiety and memory dysfunctions and in modulating the expression of BDNF and its receptor TrkB in the hippocampus, a region critically involved in anxiety and memory...
  39. Ashok K Shetty; Fiscal Year: 2015
    ..above chemicals (PB, DEET &Permethrin) and mild stress for 28 days causes considerable impairments in the hippocampus- dependent functions, which include impaired ability for new spatial learning, declined ability for making new ..
  40. Subunit dependent properties of kainate receptors
    David D Mott; Fiscal Year: 2013
    ..qRT-PCR and immunohistochemistry to determine the time course of changes in KAR subunit RNA and protein in the hippocampus during the development of epilepsy after pilocarpine-induced status epilepticus (SE)...
  41. Rita A Jablonski; Fiscal Year: 2014
    ..have heightened threat perception as a result of neurobiological changes that affect the cerebral cortex, hippocampus, and amygdale.16 These individuals may interpret mouth care as a threatening action by threatening people...
  42. microRNA analysis of neurons generated from patient-specific iPSCs
    Herbert M Lachman; Fiscal Year: 2013
    ..for Dgcr8 affects behavior, alters dendritic complexity, and influences the expression of several miRNAs in the hippocampus and cortex...
  43. Katherine M Nautiyal; Fiscal Year: 2014
    ..release in axon terminals of serotonergic and non-serotonergic neurons localized broadly in the basal ganglia, hippocampus, thalamus, cerebellum and raphe...
  44. Helen M Bramlett; Fiscal Year: 2014
    ..after TBI increases seizure threshold, reduces neuronal vulnerability and aberrant axonal sprouting in the hippocampus. Therefore, the present proposal will build on these exciting findings by investigating receptor-dependent ..
  45. John David Sweatt; Fiscal Year: 2014
    ..Much like memory formation in the hippocampus, central sensitization in the spinal cord produces pain hypersensitivity that is uncoupled from noxious input...
  46. Mark R Opp; Fiscal Year: 2016
    ..We will use this approach to quantify cytokine profiles in plasma and discrete brain regions (hypothalamus, hippocampus, brain stem) from the same animal...
  47. Stephen J Lippard; Fiscal Year: 2016
    ..by OI of hypotheses concerning the roles of mobile zinc in neurotransmission at mossy fiber synapses in the hippocampus and at glomeruli in the OB and the visualization by MRI of mobile zinc activity in the hippocampus under ..
  48. CATRINA SIMS ROBINSON; Fiscal Year: 2015
    ..The first aim of assesses the impact of obesity on insulin signaling in the hippocampus. We hypothesize that CNS insulin resistance is a major contributing factor to reduced levels of insulin in the ..
  49. Lucio G Costa; Fiscal Year: 2016
    ..Finally, primary neurons from olfactory bulb, hippocampus, and striatum neurons from mice of both genders will be exposed to DE-PM either alone or in the presence of ..
  50. Adolescent brains, nicotine and endogenous prototoxins
    Rae Nishi; Fiscal Year: 2010
    ..We predict that the cholinergic pathway from the basal forebrain to the cortex and hippocampus is not yet functionally mature in adolescents, yet an overabundance of terminals with nAChRs combined with a ..
  51. Christopher L Cunningham; Fiscal Year: 2016
    ..nucleus accumbens, bed nucleus of the stria terminalis, anterior cingulate cortex and the CA1 region of hippocampus. Neurotransmitters of interest include: dopamine, gamma-aminobutyric acid, glutamate, serotonin, and opioid ..
  52. Alpaslan Dedeoglu; Fiscal Year: 2014
    ..this effect was associated with increased angiogenesis and neuronal spine density in the dentate gyrus of the hippocampus in mice. Furthermore, improvement in spatial memory was enhanced in combination with exercise...
  53. CRCNS: Gamma Rhythms and Cell Assemblies
    Nancy Kopell; Fiscal Year: 2013
    Gamma frequency oscillations (30-90 Hz) are found in many parts of the nervous system, including the hippocampus, neocortex, entorhinal cortex and amygdala...
  54. Reactive Oxygen Species Signaling in the Hippocampus
    Eric Klann; Fiscal Year: 2012
    ..vivo, as measured by manganese enhanced magnetic resonance imaging, long-term potentiation (LTP), and impaired hippocampus-dependent memory...
  55. Jiu Chiuan Chen; Fiscal Year: 2014
    ..ambient air pollutants induce oxidative stress and neuroinflammation in multiple brain regions, especially in hippocampus and prefrontal region...
  56. Brian P Head; Fiscal Year: 2014
    ..reduced synaptosomes and their associated proteins (Cav-1, NMDAR, AMPAR, TrkR, and PSD-95) and synapses in the hippocampus;young Cav-1 KO mice exhibit early aging neuropathology...
  57. Andrey M Mazarati; Fiscal Year: 2016
    ..Further, we will examine, whether epilepsy-associated decrease of serotonin release in the hippocampus and the upregulation or raphe 5-HT1A autoreceptors can be reversed by the protracted pharmacological blockade ..
  58. miR132 regulation of neuronal plasticity, learning, and memory
    KATELIN L F HANSEN; Fiscal Year: 2013
    ..I hypothesize that miR132 is expressed in mature and developing neurons throughout the hippocampus, and its inducible expression is required for normal memory formation...
  59. Distance-Dependent Structure and Function of Neuronal Dendrites
    Kristen M Harris; Fiscal Year: 2010
    ..A rigorous plan is proposed to identify structure- function relationships along dendrites in the mature hippocampus, a brain region long known to be involved in learning and memory...
  60. Rene Hen; Fiscal Year: 2016
    ..TUC-4), and neural progenitor/neuroblasts (TUC-4-IR) will be examined along the antero-posterior axis of the hippocampus, and compared across the lifespan, between MD and normal controls and between MD patients without treatment and ..
  61. KATISHA ROSE GOPAUL; Fiscal Year: 2014
    DESCRIPTION (provided by applicant): In the hippocampus, and other brain areas, plasticity of a synapse allows it to change the way it responds based on its past history of activation, a form of cellular memory...
  62. Roger L Papke; Fiscal Year: 2016
    ..ion channel activation, in contrast, is essential for the enhancement of LTP, a memory-related process in the hippocampus. We have generated models for how the various a7-agonists dock in the ligand- binding domain of the a7 receptor ..
  63. The Role of HIF-1 in Neurogenic and Behavior Responses to Antidepressants.
    W TIMOTHY O'BRIEN; Fiscal Year: 2013
    ..Wnt/[unreadable]-catenin signaling is critical for adult neurogenesis in the hippocampus. In a recent collaboration we found that Hif-1a regulates Wnt/[unreadable]-catenin transcription in embryonic ..
  64. Jeffrey K Yao; Fiscal Year: 2014
    ..at 5 [unreadable]g/day for 1 week or six weeks following loss of ovarian function. Tissues from the hippocampus, frontal cortex, and striatum will be dissected and analyzed for levels of monoamines, monoamine metabolites, ..
  65. Rui Ming Liu; Fiscal Year: 2015
    ..We also show that O3 exposure induces oxidative stress and neuronal cell death in the cortex and hippocampus of APP/PS1 mice...
  66. Denson G Fujikawa; Fiscal Year: 2016
    ..estimate of the numbers of acidophilic and normal neurons in the most damaged brain region (probably hippocampus) and the numbers of normal neurons and those showing nuclear cyt c, cath-B and cath-D;(4) fluorometric calpain ..
  67. Karen S Wilcox; Fiscal Year: 2016
    ..Recently we used the kainic acid (KA) model of TLE to investigate 'reactive'astrocytes in the hippocampus (HC), a brain region known to be involved in seizure generation...
  68. Cytoskeletal Dynamics in Neuronal Dendrites
    Erik W Dent; Fiscal Year: 2013
    ..Because dendritic spines are the primary sites of contact with presynaptic axons in excitatory neurons of hippocampus and cortex, their structure and function have been studied in great detail...
  69. Kimberly Huber; Fiscal Year: 2016
    Project Summary: Cortical structures (the hippocampus and neocortex) are critical for cognition and perception, and their improper function is implicated in intellectual disability and autism...
  70. 18F-Mefway PET for Human Aging and Alzheimer's Disease
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..Mefway has high affinity for 5HT1A receptors and in rodent brain imaging studies exhibited selective binding in hippocampus and cortex with limited binding in the cerebellum...
  71. RONALD ROBERT SEESE; Fiscal Year: 2015
    ..b>hippocampus-dependent spatial learning activates synaptic signaling to cortactin in the WTs and if this signaling is ..
  72. Investigating the RhoA/ROCK pathway for the treatment of Alzheimer's disease
    JEREMY HARTFORD HERSKOWITZ; Fiscal Year: 2013
    ..in an AD mouse model by delivering adeno-associated virus expressing ROCK isoform specific shRNA to the hippocampus. Finally, we will test the model that activation or inhibition of RhoA reflects ROCK2-mediated effects in brain ..
  73. Mechanisms of PPAR-gamma Enhancement of Cognitive Function in Alzheimer's Disease
    Kelly T Dineley; Fiscal Year: 2013
    ..of AD patients, most notably age-dependent AB accumulation, cognitive deficits that are first apparent in hippocampus-selective learning and memory tasks, and insulin dysregulation...
  74. Yogesh Dwivedi; Fiscal Year: 2016
    ..To test our hypothesis, in brain areas implicated in suicidal behavior, i.e., dlPFC and hippocampus (cerebellum as negative control brain region) from well-characterized and well-matched depressed suicide and ..
  75. Estradiol and Hippocampal Development
    Margaret M McCarthy; Fiscal Year: 2013
    ..The hippocampus is a critical brain region for integrating external stimuli to promote learning and memory or induce stress and ..
  76. Jay S Schneider; Fiscal Year: 2016
    ..adult brain is highly dynamic and that the dynamic regulation of methylation in the prefrontal cortex (PFC) and hippocampus together play integral roles in memory formation, consolidation, and maintenance...
  77. Karin Schon; Fiscal Year: 2015
    ..between working memory and long-term memory and the role of the medial temporal lobes (including the hippocampus) and prefrontal cortex in working memory...
  78. 5-HT1A receptor anti-apoptotic transduction pathways in suicide
    Victoria Arango; Fiscal Year: 2013
    ..seem more specifically linked to major depression (anterior cingulate cortex [ACC], dorsolateral PFC [BA9] and hippocampus)...
  79. Somatic cell gene transfer/neurological &clinical applications
    En Ju Lin; Fiscal Year: 2013
    ..we noted that in the interictal state, the basal concentration of adenosine was lower in the epileptogenic hippocampus, consistent with the astrogliosis which characterizes such hippocampi...
  80. The role of CCR5 in HIV-1 Tat and morphine-mediated neurodegeneration.
    Elizabeth M Podhaizer; Fiscal Year: 2013
    ..disorders (HAND), which predominates in areas of the basal ganglia, such as the striatum, as well as the hippocampus and areas of the frontal cortex...
  81. Neuronal-Specific Splicing of CaV1.2 L-type Calcium Channels
    Kristin Webster; Fiscal Year: 2013
    ..e1a and e1b expression in specific WT and Nova-2 -/- tissues in the nervous system (cerebellum, cortex, and hippocampus) and cardiac tissue through RT-PCR. Ribonuclease protection assays will be used to quantify expression levels...
  82. Karl H Obrietan; Fiscal Year: 2014
    ..to utilize the Solexa deep sequence method to examine activity-dependent expression of non-coding RNA in the hippocampus. We will also examine the contribution of transcriptional networks that underlie activity-dependent neuronal ..
  83. Ping Yee Law; Fiscal Year: 2016
    ..nigra to the nucleus accumbens and striatum, glutaminergic inputs from the prefrontal cortex, amygdala, and hippocampus also have important roles in chronic drug action...
  84. Jiu Chiuan Chen; Fiscal Year: 2014
    ..toxicologists have revealed clear evidence of air pollution-induced neurotoxicity in the prefrontal lobe and hippocampus, epidemiologic studies have not yet examined higher cortical control functions (e.g...
  85. Paul S Buckmaster; Fiscal Year: 2016
    ..Previous rodent studies suggest in utero exposure to domoic acid might cause neuropathological changes in the hippocampus and the development of epilepsy, but direct evidence of spontaneous seizures is lacking...
  86. Experience-Dependent Synaptogenesis in Adult-Generated Neurons
    JESSICA CHANCEY; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The dentate gyrus (DG) relays information from the cortex to the hippocampus, a brain region critical for learning and memory...
  87. Stuart A Lipton; Fiscal Year: 2014
    ..Active neurogenesis normally occurs throughout life in the dentate gyrus in the hippocampus. Newly generated neurons are incorporated into the neural network, contributing to certain types of learning ..
  88. Cynthia A Lemere; Fiscal Year: 2014
    ..C3 knockout (C3KO) are C3-deficient through life. Aged male C3KO mice have more synapses in hippocampus and cortex, neurons in CA3 of hippocampus, increased gliosis, and perform better in cognitive tests compared to ..
  89. MARIA F BRAGA; Fiscal Year: 2016
    ..design-based stereology, and neurodegeneration, using Fluoro-Jade-C staining will be studied in the amygdala, hippocampus, and prefrontal cortex, at 24 hours, 1 week, 1 month, and 3 months after soman exposure...
  90. Tony Wyss-Coray; Fiscal Year: 2016
    ..Both muscle and brain (hippocampus) will be tested for transcriptional and epigenetic changes induced by exercise, both to explore the mechanisms ..
  91. Scott A Small; Fiscal Year: 2014
    ..The separate but interconnected subregions of the hippocampus are differentially vulnerable to pathogenic mechanisms, including the normal aging process...
  92. Nikolaos K Robakis; Fiscal Year: 2016
    ..reduction of glucose metabolism in regions of the AD brain affected at early stages of the disease such as hippocampus, entorhinal formation and temporal cortex...
  93. Catherine Cook Kaczorowski; Fiscal Year: 2015
    ..in mouse models of aging and AD correspond to disruption of Ca2+-dependent plasticity in neurons of the hippocampus. Albeit similar, the magnitude of neuronal dysfunction and scope of memory deficits were exacerbated in AD mice...
  94. Subroto Ghose; Fiscal Year: 2016
    ..a distinct expression profile of eCB signaling genes in the human dorsolateral prefrontal cortex (DLPFC) and hippocampus (HC), brain regions rich in CB1 receptors and repeatedly implicated in schizophrenia pathophysiology...
  95. Roger J Colbran; Fiscal Year: 2016
    ..protein kinase II (CaMKII) has diverse bidirectional roles controlling excitatory synapses in hippocampus, cortex and cerebellum...
  96. Daniel Johnston; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): There is compelling evidence for the involvement of the mammalian hippocampus in learning and memory as well as certain neurological and psychiatric disorders...
  97. Itzhak Fried; Fiscal Year: 2016
    ..that declarative memory, the ability to remember recently experienced facts and events, depends on the hippocampus and associated structures in the medial temporal lobe (MTL), including the entorhinal cortex...