cerebral ventricles

Summary

Top Publications

  1. ncbi Origin of oligodendrocytes in the subventricular zone of the adult brain
    Benedicte Menn
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7907-18. 2006
  2. pmc Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Neuro Oncol 9:424-9. 2007
  3. pmc Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database
    Sean M Nestor
    Department of Medical Biophysics, Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Brain 131:2443-54. 2008
  4. pmc Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic
    Lu Li
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Glia 58:1610-9. 2010
  5. ncbi Early central atrophy rate predicts 5 year clinical outcome in multiple sclerosis
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 81:1351-6. 2010
  6. ncbi Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice
    Anjen Chenn
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Cereb Cortex 13:599-606. 2003
  7. ncbi Effects of acute dehydration on brain morphology in healthy humans
    Matthew J Kempton
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:291-8. 2009
  8. ncbi New neurons follow the flow of cerebrospinal fluid in the adult brain
    Kazunobu Sawamoto
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
    Science 311:629-32. 2006
  9. ncbi Neuroblast division during migration toward the ischemic striatum: a study of dynamic migratory and proliferative characteristics of neuroblasts from the subventricular zone
    Rui Lan Zhang
    Neurology Department, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Neurosci 27:3157-62. 2007
  10. ncbi Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke
    Xian Shuang Liu
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    J Neurosci Res 85:2120-5. 2007

Detail Information

Publications267 found, 100 shown here

  1. ncbi Origin of oligodendrocytes in the subventricular zone of the adult brain
    Benedicte Menn
    Department of Neurosurgery and Developmental and Stem Cell Biology Program, University of California at San Francisco, San Francisco, California 94143, USA
    J Neurosci 26:7907-18. 2006
    ..Our work identifies SVZ type B cells as progenitors of oligodendrocytes in normal and injured adult brain...
  2. pmc Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Neuro Oncol 9:424-9. 2007
    ..Our MRI-based classification of GBMs may further our understanding of GBM histogenesis and help predict tumor recurrence pattern...
  3. pmc Ventricular enlargement as a possible measure of Alzheimer's disease progression validated using the Alzheimer's disease neuroimaging initiative database
    Sean M Nestor
    Department of Medical Biophysics, Centre for Functional and Metabolic Mapping, Robarts Research Institute, University of Western Ontario, London, Ontario, Canada
    Brain 131:2443-54. 2008
    ..Ventricular enlargement represents a feasible short-term marker of disease progression in subjects with MCI and subjects with AD for multi-centre studies...
  4. pmc Focal cerebral ischemia induces a multilineage cytogenic response from adult subventricular zone that is predominantly gliogenic
    Lu Li
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 0001, USA
    Glia 58:1610-9. 2010
    ..These results indicate that nestin(+) NSPCs within the SVZ mount a multilineage response to stroke that includes a gliogenic component more predominant than previously appreciated...
  5. ncbi Early central atrophy rate predicts 5 year clinical outcome in multiple sclerosis
    Carsten Lukas
    Department of Diagnostic and Interventional Radiology and Nuclear Medicine, St Josef Hospital, Ruhr University Bochum, Bochum, Germany
    J Neurol Neurosurg Psychiatry 81:1351-6. 2010
    ..To examine the predictive value of central atrophy in early multiple sclerosis (MS) patients, for medium term clinical outcome...
  6. ncbi Increased neuronal production, enlarged forebrains and cytoarchitectural distortions in beta-catenin overexpressing transgenic mice
    Anjen Chenn
    Department of Pathology, Northwestern University, Feinberg School of Medicine, Chicago, IL 60611 3008, USA
    Cereb Cortex 13:599-606. 2003
    ....
  7. ncbi Effects of acute dehydration on brain morphology in healthy humans
    Matthew J Kempton
    Centre for Neuroimaging Sciences, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:291-8. 2009
    ....
  8. ncbi New neurons follow the flow of cerebrospinal fluid in the adult brain
    Kazunobu Sawamoto
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California San Francisco, San Francisco, CA 94143, USA
    Science 311:629-32. 2006
    ..Results suggest that polarized epithelial cells contribute important vectorial information for guidance of young, migrating neurons...
  9. ncbi Neuroblast division during migration toward the ischemic striatum: a study of dynamic migratory and proliferative characteristics of neuroblasts from the subventricular zone
    Rui Lan Zhang
    Neurology Department, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Neurosci 27:3157-62. 2007
    ....
  10. ncbi Chemokine ligand 2 (CCL2) induces migration and differentiation of subventricular zone cells after stroke
    Xian Shuang Liu
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, USA
    J Neurosci Res 85:2120-5. 2007
    ..These data demonstrate that in addition to its role in cell motility, CCL2 plays an important role in neuronal differentiation...
  11. ncbi Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors
    Mladen Roko Rasin
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nat Neurosci 10:819-27. 2007
    ..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex...
  12. ncbi MicroRNA-124 is a subventricular zone neuronal fate determinant
    Malin Akerblom
    Department of Experimental Medical Science, Wallenberg Neuroscience Center and Lund Stem Cell Center, Lund University, 22184 Lund, Sweden
    J Neurosci 32:8879-89. 2012
    ..In summary, our results demonstrate that miR-124 is a neuronal fate determinant in the subventricular zone...
  13. ncbi Activation of the PI3-K/Akt pathway mediates cGMP enhanced-neurogenesis in the adult progenitor cells derived from the subventricular zone
    Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Cereb Blood Flow Metab 25:1150-8. 2005
    ..Furthermore, LY 294002 blocked Sildenafil-increased SVZ cell proliferation. These data suggest that Sildenafil-enhanced neurogenesis likely occurs through activation of the PI3-K/Akt/GSK-3 pathway...
  14. pmc Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone
    Sheng Xi Wu
    Department of Morphological Brain Science and Laboratory of Immunological Cell Biology, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Proc Natl Acad Sci U S A 102:17172-7. 2005
    ..Our data suggest that NEX-positive progenitors within the SVZ are committed to a glutamatergic neuronal fate and have evolved to expand the number of cortical output neurons that is characteristic for the mammalian forebrain...
  15. ncbi Neurogenesis and glial proliferation persist for at least one year in the subventricular zone following brain trauma in rats
    Xiao Han Chen
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 20:623-31. 2003
    ..These data suggest that there is a persistent proliferation of neurons and glia in the SVZ following brain trauma that does not diminish during aging as found in non-injured animals...
  16. pmc NMDA receptors activated by subventricular zone astrocytic glutamate are critical for neuroblast survival prior to entering a synaptic network
    Jean Claude Platel
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520 8082, USA
    Neuron 65:859-72. 2010
    ..In addition, our findings suggest an unexpected mechanism wherein SVZ astrocytes use glutamate signaling through NMDARs to control the number of adult-born neurons reaching their final destination...
  17. ncbi A cross-sectional and follow-up voxel-based morphometric MRI study in adolescent anorexia nervosa
    Josefina Castro-Fornieles
    Department of Child and Adolescent Psychiatry and Psychology, Institute Clinic of Neurosciences, Hospital Clinic, University of Barcelona, Centro de Investigación Biomédica en Red de Salud Mental CIBER sam, Barcelona, Spain
    J Psychiatr Res 43:331-40. 2009
    ..In conclusion, in adolescent anorexic patients gray matter is more affected than white matter and mainly involves the posterior regions of the brain. Overall gray matter alterations are reversible after nutritional recovery...
  18. ncbi Crucial role for Ser133-phosphorylated form of cyclic AMP-responsive element binding protein signaling in the differentiation and survival of neural progenitors under chronic cerebral hypoperfusion
    N Miyamoto
    Department of Neurology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Neuroscience 162:525-36. 2009
    ..Our results indicated that cAMP-responsive element binding protein signaling is a key mediator of neurogenesis after prolonged hypoperfusion and provide the basis for new regenerative therapies for ischemic brain injury...
  19. ncbi Functional identification of neural stem cell-derived oligodendrocytes by means of calcium transients elicited by thrombin
    Sofia Grade
    Neuroprotection and Neurogenesis in Brain Repair Group, Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, Coimbra, Portugal
    Rejuvenation Res 13:27-37. 2010
    ..Additionally, it opens new perspectives for the search of new pro-oligodendrogenic factors to be used prior grafting...
  20. ncbi Periventricular hemorrhagic infarction: risk factors and neonatal outcome
    Haim Bassan
    Department of Neurology, Neonatal Neurology Research Group, Children s Hospital Boston and Harvard Medical School, Boston Massachusetts 02115, USA
    Pediatr Neurol 35:85-92. 2006
    ..A growing population of survivors is apparent among infants with birth weight<750 gm. Multiple hemodynamic factors associated with periventricular hemorrhagic infarction cluster in the intrapartum and early neonatal periods...
  21. pmc Oligodendrogenesis in the subventricular zone and the role of epidermal growth factor
    Oscar Gonzalez-Perez
    Laboratory of Neuroscience, School of Psychology, University of Colima, Colima, Colima 28040, Mexico
    Brain Res Rev 67:147-56. 2011
    ....
  22. ncbi Neurodevelopmental outcome in children with intraventricular hemorrhage
    Yasuyuki Futagi
    Division of Pediatric Neurology, Osaka Medical Center and Research Institute for Maternal and Child Health, Osaka, Japan
    Pediatr Neurol 34:219-24. 2006
    ..The overall incidence of epilepsy was 39/335 (11.6%). This study has not demonstrated clear improvement of the outcome in children with intraventricular hemorrhage between the 1980s and 1990s...
  23. ncbi A prospective study of fetuses with isolated ventriculomegaly investigated by antenatal sonography and in utero MR imaging
    P D Griffiths
    Academic Unit of Radiology, University of Sheffield, Sheffield, UK
    AJNR Am J Neuroradiol 31:106-11. 2010
    ....
  24. ncbi Characterization of acute brain injuries and neurobehavioral profiles in a rabbit model of germinal matrix hemorrhage
    Paraskevi Georgiadis
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, NY, USA
    Stroke 39:3378-88. 2008
    ..Despite this, there is no standardized animal model of IVH depicting acute brain injuries...
  25. pmc Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia
    Elisabeth C W van Straaten
    Dept of Neurology and Alzheimer Center, VU Medical Center, De Boelelaan 1117, 7057, 1007 MB, Amsterdam, The Netherlands
    J Neurol 255:1302-8. 2008
    ..The influence of WMH on progression of aMCI to Alzheimer's disease (AD) is less clear...
  26. pmc The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone
    Hai Kun Liu
    Division of Molecular Biology of the Cell I, German Cancer Research Center DKFZ, Heidelberg 69120, Germany
    Genes Dev 22:2473-8. 2008
    ..These findings demonstrate the crucial role of Tlx in the generation and maintenance of NSCs in the adult SVZ in vivo...
  27. ncbi Atrophic enlargement of CSF volume after subarachnoid hemorrhage: correlation with neuropsychological outcome
    P Bendel
    Department of Clinical Radiology, Kuopio University Hospital and University of Kuopio, Finland
    AJNR Am J Neuroradiol 31:370-6. 2010
    ..Our aim was to quantify the late ventricular dilation and volumes of the CSF spaces after aSAH and to determine if they correlate with neurologic and cognitive impairments frequently detected in these patients...
  28. ncbi Ventricular enlargement in multiple sclerosis: a comparison of three-dimensional and linear MRI estimates
    B Turner
    Division of Clinical Neurology, Medical School, University Hospital, Queen's Medical Centre, Nottingham, UK
    Neuroradiology 43:608-14. 2001
    ....
  29. ncbi Adenomatous polyposis coli is essential for both neuronal differentiation and maintenance of adult neural stem cells in subventricular zone and hippocampus
    Tetsuya Imura
    Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Stem Cells 28:2053-64. 2010
    ..stem cells 2010;28:2053-2064...
  30. ncbi Prevention of external ventricular drain--related ventriculitis
    A M Korinek
    Neuroanaesthesia Unit, Department of Anaesthesiology, Pitie Salpetriere University Hospital, University of Paris VI, Paris, France
    Acta Neurochir (Wien) 147:39-45; discussion 45-6. 2005
    ....
  31. ncbi Consequences of neural cell adhesion molecule deficiency on cell migration in the rostral migratory stream of the mouse
    G Chazal
    Laboratoire de Genetique et Physiologie du Developpement, Institut de Biologie du Developpement de Marseille, Centre National de la Recherche Scientifique Université de la Santé et de la Recherche Medicale, INSERM, Paris Cedex, France
    J Neurosci 20:1446-57. 2000
    ....
  32. ncbi External ventricular drain infection: the effect of a strict protocol on infection rates and a review of the literature
    D Dasic
    Department of Neurological Surgery, Radcliffe Infirmary, Oxford, UK
    Br J Neurosurg 20:296-300. 2006
    ..This study demonstrates that adherence to an evidence-based protocol for their insertion and management is associated with a significant reduction in the infection rate...
  33. ncbi Enlarged perivascular spaces on MRI are a feature of cerebral small vessel disease
    Fergus N Doubal
    MRCP, Division of Clinical Neurosciences, Bramwell Dott Building, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK
    Stroke 41:450-4. 2010
    ..They may reflect underlying cerebral small vessel disease. We determined whether enlarged perivascular spaces were associated with lacunar stroke subtype and white matter hyperintensities, markers of established small vessel disease...
  34. pmc Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion
    JOHN M STAFFORD
    Division of Diabetes, Endocrinology, and Metabolism, Department of Internal Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Diabetes 57:1482-90. 2008
    ....
  35. ncbi Differential activation of microglia in neurogenic versus non-neurogenic regions of the forebrain
    Gwendolyn E Goings
    Children s Memorial Research Center, Neurobiology Program, Children s Memorial Hospital, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Glia 54:329-42. 2006
    ..Our data show that both constitutive and postlesion levels of microglial activation differ between neurogenic and non-neurogenic regions...
  36. pmc Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo
    Xiaomei Wang
    Buck Institute for Age Research, Novato, California, USA
    J Cereb Blood Flow Metab 29:1644-54. 2009
    ..Finally, ischemia-induced cell proliferation in the SVZ was blocked by inhibition of the Notch1 signaling pathway, suggesting that Notch1 signaling may have a key role in normal adult and ischemia-induced neurogenesis...
  37. ncbi Nitric oxide decreases subventricular zone stem cell proliferation by inhibition of epidermal growth factor receptor and phosphoinositide-3-kinase/Akt pathway
    Ana Torroglosa
    Area de Fisiologia, Facultad de Medicina, Universidad de Cadiz, Plaza Falla 9, 11003 Cadiz, Spain
    Stem Cells 25:88-97. 2007
    ....
  38. ncbi Proliferation in the human ipsilateral subventricular zone after ischemic stroke
    J Marti-Fabregas
    Department of Neurology, Hospital de la Santa Creu i Sant Pau, Avda Sant Antoni Maria Claret, 167, 08025 Barcelona, Spain
    Neurology 74:357-65. 2010
    ..It is uncertain whether neurogenesis occurs in humans after stroke. We studied the morphologic changes that occurred in the subventricular zone (SVZ) in patients who died following an acute ischemic stroke...
  39. ncbi Cell output, cell cycle duration and neuronal specification: a model of integrated mechanisms of the neocortical proliferative process
    V S Caviness
    Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cereb Cortex 13:592-8. 2003
    ..The results indicate that events affecting the output of the proliferative population affect both the number of neurons produced and their specification with regard to their laminar fate...
  40. ncbi Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat
    Ruilan Zhang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Neurosci 24:5810-5. 2004
    ..Our data suggest that neurons are produced by both asymmetric and symmetric cell divisions in the adult SVZ, and the transient increases in symmetric division and neuronal differentiation may result in stroke-induced neurogenesis...
  41. ncbi Neuropeptide Y promotes neurogenesis in murine subventricular zone
    Fabienne Agasse
    Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    Stem Cells 26:1636-45. 2008
    ..NPY, as a promoter of SVZ neurogenesis, is a crucial factor for future development of cell-based brain therapy. Disclosure of potential conflicts of interest is found at the end of this article...
  42. pmc The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone
    Sebastian J Arnold
    Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, United Kingdom
    Genes Dev 22:2479-84. 2008
    ..Neurogenesis in the adult dentate gyrus but not the subependymal zone is abolished. These studies establish Tbr2 as a key regulator of neurogenesis in the SVZ...
  43. pmc Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion
    Ira Adams-Chapman
    Department of Pediatrics Division of Neonatology, Emory University School of Medicine, 46 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
    Pediatrics 121:e1167-77. 2008
    ..We aimed to evaluate neurodevelopmental and growth outcomes among extremely low birth weight infants who had severe intraventricular hemorrhage that required shunt insertion compared with infants without shunt insertion...
  44. ncbi Neurodevelopmental outcome of preterm infants with severe intraventricular hemorrhage and therapy for post-hemorrhagic ventricular dilatation
    Annemieke Brouwer
    Department of Neonatology, Wilhelmina Children s Hospital, University Medical Center, Utrecht, The Netherlands
    J Pediatr 152:648-54. 2008
    ..To evaluate the neurodevelopmental outcome of preterm infants with a grade III or IV hemorrhage and to assess the effect of routine low-threshold therapy of post-hemorrhagic ventricular dilatation (PHVD) on neurodevelopmental outcome...
  45. ncbi A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner
    Maria Beatriz Goncalves
    Wolfson Centre for Age Related Diseases, King s College, London SE1 9RT, UK
    Mol Cell Neurosci 38:526-36. 2008
    ..These data identify CB2 receptor agonists and FAAH inhibitors as agents that can counteract the naturally observed decline in adult neurogenesis that is associated with ageing...
  46. pmc Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult mice
    Francoise Lazarini
    Institut Pasteur, Laboratory for Perception and Memory, Paris, France
    PLoS ONE 4:e7017. 2009
    ..Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear...
  47. pmc Phenotypic and functional characterization of adult brain neuropoiesis
    Bjorn Scheffler
    Departments of Neuroscience and Neurosurgery, University of Florida, McKnight Brain Institute, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 102:9353-8. 2005
    ....
  48. ncbi Neurogenic radial glial cells in reptile, rodent and human: from mitosis to migration
    Tamily Weissman
    Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, 630 W 168th Street, New York, NY 10032, USA
    Cereb Cortex 13:550-9. 2003
    ..Although radial glial cells have traditionally been characterized by their role in guiding migration, their role as neuronal progenitors may represent their defining characteristic throughout the vertebrate CNS...
  49. pmc Distinct mammalian precursors are committed to generate neurons with defined dendritic projection patterns
    Wolfgang Kelsch
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS Biol 5:e300. 2007
    ..Our results demonstrate that, at least in the neonatal and adult mammalian brain, the pattern of dendritic targeting of a given neuron is a cell-autonomous property of their precursors...
  50. pmc Brain specific proteins in posthaemorrhagic ventricular dilatation
    A Whitelaw
    Division of Child Health, University of Bristol, Bristol, UK
    Arch Dis Child Fetal Neonatal Ed 84:F90-1. 2001
    ..S-100 protein in cerebrospinal fluid was four times higher than control values. Glial fibrillary acidic protein concentrations correlated with death or disability and with parenchymal lesions but not with shunt dependence...
  51. ncbi Expression of Cux-1 and Cux-2 in the subventricular zone and upper layers II-IV of the cerebral cortex
    Marta Nieto
    Department of Neurology, Harvard Medical School and Howard Hughes Medical Institute, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    J Comp Neurol 479:168-80. 2004
    ..The patterns of expression of Cux genes suggest potential roles as determinants of the neuronal fate of the upper cortical layer neurons...
  52. ncbi Ischemic cerebral tissue response to subventricular zone cell transplantation measured by iterative self-organizing data analysis technique algorithm
    Lian Li
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan 48202, USA
    J Cereb Blood Flow Metab 26:1366-77. 2006
    ..Angiogenesis was present in sites either immediately adjacent to or surrounded by the grafted cells. Our data indicate that map-ISODATA accurately and dynamically characterizes the ischemic lesion and its response to cell therapy...
  53. ncbi Removal of polysialic acid triggers dispersion of subventricularly derived neuroblasts into surrounding CNS tissues
    Daniela Battista
    Laboratory of Cellular and Developmental Neuroscience, Department of Cell Biology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    J Neurosci 30:3995-4003. 2010
    ..These findings suggest that the presence of NCAM without PSA plays a role in the dispersion process, possibly by inducing a new pattern of migration associated with NCAM-dependent differentiation...
  54. ncbi Reelin induces the detachment of postnatal subventricular zone cells and the expression of the Egr-1 through Erk1/2 activation
    Sergi Simo
    Developmental Neurobiology and Regeneration Laboratory, Barcelona Science Park IRB and Department of Cell Biology, University of Barcelona, E 08028 Barcelona, Spain
    Cereb Cortex 17:294-303. 2007
    ....
  55. ncbi Postnatal neurogenesis and gliogenesis in the olfactory bulb from NG2-expressing progenitors of the subventricular zone
    Adan Aguirre
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 24:10530-41. 2004
    ..Our findings indicate region-specific differences between NG2+ progenitor cells and show that NG2+ cells can migrate throughout the RMS and contribute to both gliogenesis and neurogenesis in the postnatal OB...
  56. ncbi Intraventricular fibrinolysis versus external ventricular drainage alone in intraventricular hemorrhage: a meta-analysis
    Thomas Gaberel
    Department of Neurosurgery, Caen University Hospital, and Sérene Protease and Pathophysiology of the Neurovascular Unit, Centre d Imagerie et de Neurosciences Appliquées aux Pathologies, University Caen Lower Normandy, Avenue de la Cote de Nacre, Caen, F 14000, France
    Stroke 42:2776-81. 2011
    ....
  57. ncbi Neuroendoscopic removal of intraventricular hemorrhage combined with hydrocephalus
    H Hamada
    Department of Neurosurgery, Faculty of Medicine, University of Toyama, Toyama, Japan
    Minim Invasive Neurosurg 51:345-9. 2008
    ..Hydrocephalus associated with intraventricular hemorrhage (IVH) is a good indication for neuroendoscopic surgery. We describe herein our experiences with 17 cases of IVH combined with hydrocephalus treated using a neuroendoscope...
  58. ncbi Comparison of clinical outcomes of intraventricular hematoma between neuroendoscopic removal and extraventricular drainage
    Fuminari Komatsu
    Department of Neurosurgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    Neurol Med Chir (Tokyo) 50:972-6. 2010
    ..The procedure resulted in faster removal of the catheter in the postoperative period and earlier patient ambulation...
  59. pmc Brain ventricular volume and cerebrospinal fluid biomarkers of Alzheimer's disease
    Brian R Ott
    Department of Neurology, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA
    J Alzheimers Dis 20:647-57. 2010
    ..The basis for the apparent effect of APOE epsilon4 genotype on the relationship of ventricular volume to Abeta and tau levels is unknown, but could involve altered CSF-blood-brain barrier function during the course of disease...
  60. ncbi Application of neuroendoscopy in the treatment of intraventricular hemorrhage
    Zaiqiang Zhang
    Department of Neurosurgery, Qilu Hospital of Shandong University, Jinan, PR China
    Cerebrovasc Dis 24:91-6. 2007
    ..The objective of this article is to compare different surgical procedures in order to evaluate a method of minimally invasive treatment for intraventricular hemorrhage...
  61. ncbi Delineation of multiple subpallial progenitor domains by the combinatorial expression of transcriptional codes
    Nuria Flames
    Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
    J Neurosci 27:9682-95. 2007
    ..Furthermore, the results of microtransplantation experiments in vivo corroborate that anatomically defined regions of the mouse subpallium, such as the medial ganglionic eminence, can be subdivided into functionally distinct domains...
  62. ncbi Carmustine wafer implantation when surgical cavity is communicating with cerebral ventricles: technical considerations on a clinical series
    Alessandro Della Puppa
    Department of Neurosurgery, Padua University Hospital, Padova, Italy
    World Neurosurg 76:156-9; discussion 67-8. 2011
    ..Furthermore, there are no technical suggestions in literature put forward for the surgical repairing of ventricular defects. Our study was particularly focused on addressing these 3 issues...
  63. ncbi [New treatment strategies for intraventricular hemorrhage]
    D Staykov
    Neurologische Klinik, Universitatsklinikum Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland
    Med Klin Intensivmed Notfmed 107:192-6. 2012
    ..The present article gives an overview of pathophysiological and clinical aspects of IVH, emphasizing novel treatment options...
  64. ncbi External ventricular drainage alone versus endoscopic surgery for severe intraventricular hemorrhage: a comparative retrospective analysis on outcome and shunt dependency
    Luca Basaldella
    Department of Neurosurgery, Treviso Regional Hospital, University of Padova, Treviso, Italy
    Neurosurg Focus 32:E4. 2012
    ..Neuroendoscopy may offer some advantages over more traditional surgical approaches on outcome and may decrease the number of shunt procedures that need to be performed...
  65. pmc Endoscopic management of hypertensive intraventricular haemorrhage with obstructive hydrocephalus
    Yad Ram Yadav
    NSCB Medical College and Hospital, Jabalpur, India
    BMC Neurol 7:1. 2007
    ..We report the results following endoscopic decompression of obstructive hydrocephalus and evacuation of haematoma in patients with hypertensive intraventricular haemorrhage...
  66. ncbi New reference values for the neonatal cerebral ventricles
    Margaretha J Brouwer
    Department of Neonatology, University Medical Center Utrecht Wilhelmina Children s Hospital, Post box 85090, 3508 AB Utrecht, The Netherlands
    Radiology 262:224-33. 2012
    ....
  67. ncbi Management of non-traumatic intraventricular hemorrhage
    Thomas Gaberel
    Department of Neurosurgery, Caen University Hospital, Avenue de la Cote de Nacre, Caen, 14000, France
    Neurosurg Rev 35:485-94; discussion 494-5. 2012
    ..IVH represents a therapeutic challenge for neurosurgeons, neurologists, and intensivists. Thus, a better understanding of this dramatic event will help in better tailoring the treatment strategies...
  68. ncbi Influence of intraventricular hemorrhage and occlusive hydrocephalus on the long-term outcome of treated patients with basal ganglia hemorrhage: a case-control study
    Hagen B Huttner
    Department of Neurology, University of Heidelberg, Germany
    J Neurosurg 105:412-7. 2006
    ..The aim of this study was to compare the long-term outcome of patients with pure ganglionic hemorrhage and those requiring an EVD due to additional IVH and hydrocephalus...
  69. ncbi Dynamics of intraventricular hemorrhage in patients with spontaneous intracerebral hemorrhage: risk factors, clinical impact, and effect of hemostatic therapy with recombinant activated factor VII
    Thorsten Steiner
    Department of Neurology, Univesity of Heidelberg, Heidelberg, Germany
    Neurosurgery 59:767-73; discussion 773-4. 2006
    ..To evaluate predictors of intraventricular hemorrhage (IVH) and IVH growth, impact of IVH growth on outcome, and impact of recombinant activated factor VII (rFVIIa) in patients with intracerebral hemorrhage (ICH)...
  70. ncbi The angiogenic factor angiopoietin-1 is a proneurogenic peptide on subventricular zone stem/progenitor cells
    Alexandra I Rosa
    Neuroprotection and Neurogenesis in Brain Repair Group, Center for Neuroscience and Cell Biology, Institute of Biochemistry, Faculty of Medicine, Institute of Pharmacology and Experimental Therapeutics, and Institute of Biomedical Research on Light and Image, Faculty of Medicine, University of Coimbra, 3004 504 Coimbra, Portugal
    J Neurosci 30:4573-84. 2010
    ..Our work shows a proneurogenic effect of Ang-1, highlighting the relevance of blood vessel/stem cell cross talk in health and disease...
  71. ncbi A quantitative index of intracranial cerebrospinal fluid distribution in normal pressure hydrocephalus using an MRI-based processing technique
    A Tsunoda
    Department of Neurosurgery, Koshigaya Municipal Hospital, Saitama, Japan
    Neuroradiology 42:424-9. 2000
    ..In contrast, no subject in the other groups had a VV/ICV ratios higher than 30%. We conclude that these CSF volume parameters, especially the VV/ICV ratio, are useful for the diagnosis of NPH...
  72. ncbi Endoscopic surgery for intraventricular hemorrhage (IVH) caused by thalamic hemorrhage: comparisons of endoscopic surgery and external ventricular drainage (EVD) surgery
    Chun Chung Chen
    Department of Neurosurgery, China Medical University Hospital, Taichung, Taiwan, Republic of China
    World Neurosurg 75:264-8. 2011
    ..The aim of this study was to investigate the efficacy and the results of endoscopic surgery for the evacuation of IVH caused by thalamic hemorrhage compared with that of external ventricular drainage (EVD) surgery...
  73. ncbi Animal models of germinal matrix hemorrhage
    Janani Balasubramaniam
    Department of Pathology, University of Manitoba and Manitoba Instititute of Child Health, Winnipeg, MB, Canada
    J Child Neurol 21:365-71. 2006
    ..This literature review critically evaluates the animal models of germinal matrix hemorrhage. Each model has its own advantages and disadvantages; no single model is suitable for the study of all aspects of brain damage...
  74. ncbi Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial
    T Morgan
    Johns Hopkins University, 1550 Orleans Street, CRB II 3M50 South, Baltimore, MD 21231, USA
    Acta Neurochir Suppl 105:217-20. 2008
    ..e., approximately 80% removal over 48 h). The purpose of the CLEAR-IVH trial (Parts A and B) is to evaluate safety and efficacy of using multiple injections of low-dose rt-PA to accelerate lysis and evacuation of IVH...
  75. ncbi The ependyma in chronic hydrocephalus
    M Kiefer
    Department of Neurosurgery, Saarland University, Homburg, Germany
    Childs Nerv Syst 14:263-70. 1998
    ....
  76. ncbi The cortical subventricular zone-specific molecule Svet1 is part of the nuclear RNA coded by the putative netrin receptor gene Unc5d and is expressed in multipolar migrating cells
    Shinji Sasaki
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mol Cell Neurosci 38:474-83. 2008
    ..Thus, the previously reported "SVZ-specific expression of the Svet1 RNA" in fact indicates putative involvement of UNC5D signaling in the multipolar migrating cells...
  77. ncbi High-frequency ultrasound in the evaluation of cerebral intraventricular haemorrhage in preterm rabbit pups
    Snjolaug Sveinsdottir
    Division of Pediatrics, Department of Clinical Sciences Lund, Lund University, Lund, Sweden
    Ultrasound Med Biol 38:423-31. 2012
    ..Application of HFU is a powerful tool for the evaluation of mechanisms involved in cerebral IVH and PHVD in the preterm rabbit pup model...
  78. ncbi Reducing the incidence of intraventricular catheter-related ventriculitis in the neurology-neurosurgical intensive care unit at a tertiary care center in St Louis, Missouri: an 8-year follow-up study
    Hitoshi Honda
    Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Infect Control Hosp Epidemiol 31:1078-81. 2010
    ..The incidence density of intraventricular catheter-related ventriculitis decreased substantially after the implementation of standardized management of intraventricular catheters...
  79. ncbi Intraventricular haemorrhage and posthaemorrhagic hydrocephalus: pathogenesis, prevention and future interventions
    A Whitelaw
    Division of Child Health, University of Bristol Medical School, Southmead Hospital, Bristol BS9 1PJ, UK
    Semin Neonatol 6:135-46. 2001
    ..New treatment approaches aimed at preventing hydrocephalus are needed...
  80. ncbi Computational model of the cerebral ventricles in hydrocephalus
    Shaokoon Cheng
    Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia
    J Biomech Eng 132:054501. 2010
    ..This may not be adequate as the geometry of the cerebral ventricles is unique...
  81. ncbi Dysfunction of axonemal dynein heavy chain Mdnah5 inhibits ependymal flow and reveals a novel mechanism for hydrocephalus formation
    Ines Ibanez-Tallon
    Laboratory of Molecular Biology, Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA
    Hum Mol Genet 13:2133-41. 2004
    ..The higher incidence of aqueduct stenosis and hydrocephalus formation in patients with ciliary defects proves the relevance of this novel mechanism in humans...
  82. ncbi Mutations in filamin 1 prevent migration of cerebral cortical neurons in human periventricular heterotopia
    J W Fox
    Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, Massachusetts 02115, USA
    Neuron 21:1315-25. 1998
    ..FLN1 shows previously unrecognized, high-level expression in the developing cortex, is required for neuronal migration to the cortex, and is essential for embryogenesis...
  83. ncbi Deletion including the oligophrenin-1 gene associated with enlarged cerebral ventricles, cerebellar hypoplasia, seizures and ataxia
    D Tentler
    Department of Genetics and Pathology, Uppsala University Hospital, Sweden
    Eur J Hum Genet 7:541-8. 1999
    ..Cranial MRI scans show enlargement of the cerebral ventricles and cerebellar hypoplasia...
  84. ncbi The relationship between intracranial pressure and size of cerebral ventricles assessed by computed tomography
    P K Eide
    Department of Neurosurgery, The National Hospital, University of Oslo, Sognvannsveien 20, N 0027 Oslo, Norway
    Acta Neurochir (Wien) 145:171-9; discussion 179. 2003
    ..This study explored whether assessment of the cerebral ventricular size (or changes in size) by cranial computed tomography (CT) is a reliable way to predict the intracranial pressure (ICP)...
  85. ncbi Serum procalcitonin monitoring for differential diagnosis of ventriculitis in adult intensive care patients
    R Martinez
    Department of Neurosurgery, University of Dresden, Fetscherstrasse 74, 01307 Dresden, Germany
    Intensive Care Med 28:208-10. 2002
    ..The value of PCT as an additional marker with which to assess the efficacy of therapy in ventriculitis is suggested, but requires further assessment...
  86. ncbi Cell index--a new parameter for the early diagnosis of ventriculostomy (external ventricular drainage)-related ventriculitis in patients with intraventricular hemorrhage?
    B Pfausler
    Department of Neurology, University Hospital Innsbruck, Innsbruck, Austria
    Acta Neurochir (Wien) 146:477-81. 2004
    ..The aim of this prospective study was to validate a new parameter for the early detection of an intraventricular infection...
  87. ncbi Effect of repetitive icv injections of ANG II on c-Fos and AT(1)-receptor expression in the rat brain
    E Moellenhoff
    Institute of Pharmacology, University of Kiel, Hospitalstrasse 4, 24105 Kiel, Germany
    Am J Physiol Regul Integr Comp Physiol 280:R1095-104. 2001
    ....
  88. pmc The Notch pathway mediates expansion of a progenitor pool and neuronal differentiation in adult neural progenitor cells after stroke
    L Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, MI 48202, USA
    Neuroscience 158:1356-63. 2009
    ..These data suggest that the Notch signaling pathway mediates adult SVZ neural progenitor cell proliferation and differentiation after stroke...
  89. ncbi Subventricular zone neuroblasts emigrate toward cortical lesions
    Nikki L Sundholm-Peters
    CMRC Neurobiology Program, Children s Memorial Hospital, Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60614 3394, USA
    J Neuropathol Exp Neurol 64:1089-100. 2005
    ....
  90. ncbi Cortical neurogenesis enhanced by chronic perinatal hypoxia
    Devon M Fagel
    Child Study Center, Yale University Medical School, 230 South Frontage Road, New Haven, CT 06520, USA
    Exp Neurol 199:77-91. 2006
    ..We suggest that cortical neurogenesis may play a significant role in repairing neuronal losses after neonatal injury...
  91. ncbi Intracerebroventricular neuropeptide Y infusion precludes inhibition of glucose and VLDL production by insulin
    Anita M van den Hoek
    Organization of Applied Scientific Research Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Diabetes 53:2529-34. 2004
    ....
  92. ncbi Neuronal progenitor cells derived from the anterior subventricular zone of the neonatal rat forebrain continue to proliferate in vitro and express a neuronal phenotype
    M B Luskin
    Department of Anatomy, Emory University School of Medicine, George Washington University Medical Center, 2300 Eye St, N W, Atlanta, Georgia, 30322, USA
    Mol Cell Neurosci 8:351-66. 1997
    ..Thus, the neuronal progenitor cells of the SVZa constitute a unique cell population with characteristics distinct from the cells of other germinal zones...
  93. ncbi The cellular composition and morphological organization of the rostral migratory stream in the adult human brain
    Monica Kam
    Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    J Chem Neuroanat 37:196-205. 2009
    ..These findings contribute to the scientific understanding of adult neurogenesis and establish the detailed cytoarchitecture of this novel neurogenic niche in the human brain...
  94. ncbi Randomized clinical trial of prevention of hydrocephalus after intraventricular hemorrhage in preterm infants: brain-washing versus tapping fluid
    Andrew Whitelaw
    Department of Clinical Science at North Bristol, University of Bristol, Bristol, United Kingdom
    Pediatrics 119:e1071-8. 2007
    ..The aim of this study was to test a new treatment intended to prevent hydrocephalus and shunt dependence after intraventricular hemorrhage...
  95. ncbi Serum procalcitonin in cerebral ventriculitis
    Christian Berger
    Department of Neurology and Neurosurgery, University of Heidelberg, Germany
    Crit Care Med 30:1778-81. 2002
    ..The objective of this study was to test the hypothesis that serum procalcitonin is increased in patients with bacterial cerebral ventricular infections after the insertion of temporary external ventricular drains...
  96. ncbi Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors
    Sara Gil-Perotin
    Department Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    J Neurosci 26:1107-16. 2006
    ..Together, these findings provide a cellular mechanism for how the slow-proliferating SVZ cells can give rise to glial tumors in the adult brain...
  97. ncbi Regional specificity of cerebrospinal fluid abnormalities in first episode schizophrenia
    Katherine L Narr
    Laboratory of Neuroimaging, Division of Brain Mapping, UCLA School of Medicine, 710 Westwood Plaza, Los Angeles, CA 90095 1769, USA
    Psychiatry Res 146:21-33. 2006
    ..In contrast, sulcal and subarachnoid CSF increases may be manifest near or before the first episode but after brain development is complete, reflecting pronounced reductions in proximal brain tissue...
  98. ncbi Chronic hypoxia up-regulates fibroblast growth factor ligands in the perinatal brain and induces fibroblast growth factor-responsive radial glial cells in the sub-ependymal zone
    Y Ganat
    Child Study Center, Yale University, 230 South Frontage Road, New Haven, CT 06520, USA
    Neuroscience 112:977-91. 2002
    ....
  99. ncbi Roles of the mammalian subventricular zone in cell replacement after brain injury
    Michael J Romanko
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Prog Neurobiol 74:77-99. 2004
    ..By reviewing, comparing and contrasting the responses of the SVZs to different injuries, our goal is to provide a foundation from which current and future studies on the potential of the SVZs for cell replacement can be evaluated...
  100. ncbi Ventricular enlargement in schizophrenia related to volume reduction of the thalamus, striatum, and superior temporal cortex
    Christian Gaser
    Department of Psychiatry, Friedrich Schiller University of Jena, Germany
    Am J Psychiatry 161:154-6. 2004
    ..The authors investigated whether ventricular enlargement is related to regionally specific volume loss...
  101. ncbi Non-protein-bound iron is elevated in cerebrospinal fluid from preterm infants with posthemorrhagic ventricular dilatation
    K Savman
    Department of Pediatrics, , The Queen Silvia Children's Hospital, , Sweden
    Pediatr Res 49:208-12. 2001
    ..NPBI was increased in CSF from preterm infants with PHVD, and the increase could not be explained by hemolysis alone. Free iron may help to explain the association between intraventricular hemorrhage and white matter damage...

Research Grants72

  1. Diabetes suppresses sympathetic neurotransmission and thereby glucagon secretion
    Gerald J Taborsky; Fiscal Year: 2013
    ..ganglionic neurotransmission, we will restore euglycemia, without insulin, by infusing leptin into the cerebral ventricles of STZ diabetic rats...
  2. DTI, MRSI, and Volumetry of Cerebellar Injury in Preterm Neonates
    Anthony James Barkovich; Fiscal Year: 2013
    ..of the baby and with two common conditions of the brain in prematurely born neonates: hemorrhage into the cerebral ventricles, and injury of the cerebral white matter...
  3. Role of Neural Progenitor Cells in the Development of Neonatal Hydrocephalus
    Val C Sheffield; Fiscal Year: 2013
    ..Hydrocephalus leads to the expansion of cerebral ventricles and is associated with significant morbidity and mortality with mortality rates as high as 35%...
  4. BLOOD-BRAIN BARRIER IN NORMAL & EXPERIMENTAL BRAIN
    RICHARD BROADWELL; Fiscal Year: 1990
    ..Molecules that will be administered intravenously or injected into the cerebral ventricles and investigated for transcytosis are wheatgerm agglutinin, transferrin, insulin, albumin, cationized ..
  5. FIBROBLAST GROWTH FACTOR CEREBRAL CORTICAL DEVELOPMENT
    Flora Vaccarino; Fiscal Year: 2002
    ..Adult rats microinjected with FGF2 in the cerebral ventricles during embryogenesis have an increased number of cortical neurons, whereas mice lacking the FGF2 gene ..
  6. NEUROLOGICAL BASES OF FEEDING AND DRINKING
    ELIOT STELLAR; Fiscal Year: 1992
    ..mineralocorticoid (DOCA or aldosterone) combined with infusions of low doses of angiotensin II into the cerebral ventricles of the sodium replete rat induce a rapid, reliable, and robust appetite for salt, and the salt appetite of ..
  7. Choroid plexus macrophages in FIV neuropathogenesis
    RICK MEEKER; Fiscal Year: 2009
    ..Our recent data have indicated that FIV introduced directly into the cerebral ventricles can produce greater CNS infection and increased viral RNA in the cerebrospinal fluid (CSF)...
  8. FUNCTIONAL STUDIES OF BRAIN EXTRACELLULAR FLUIDS
    HELEN CSERR; Fiscal Year: 1993
    ..Techniques include: intracerebral microinjection; perfusion of cerebral ventricles and subarachnoid space; collection of deep cervical lymph; quantitative autoradiography; measurement of ISF ..
  9. GENERATION OF CELL DIVERSITY IN THE CEREBRAL CORTEX
    JAMES BARFIELD; Fiscal Year: 1991
    ..of clonally related cells will be examined following the injection of a retroviral lineage tracer into the cerebral ventricles of rat embryos at a variety of ages...
  10. STIMULUS CONTROL BY HALLUCINOGENS--SSRI INTERACTIONS
    JUSTIN ECKLER; Fiscal Year: 2002
    ..SSRI's will be injected into rat cerebral ventricles to determine if a metabolite or the parent SSRI is altering the stimulus properties of DOM...
  11. TAURINE AND EPILEPSY
    HUGH LAIRD; Fiscal Year: 1980
    ..the problem of general behavioral effects which are obtained when substances are administered into the cerebral ventricles. The information obtained will be of general applicability in the understanding of the pathological changes ..
  12. EARLY EXPERIENCE AT THE NIPPLE: ENDOGENOUS OPIOID SYSTEM
    EVGENIY PETROV; Fiscal Year: 1999
    ..drugs specific to mu (CTOP) or kappa (nor-BNI) opioid receptors will be injected into the cisterna magna or cerebral ventricles of the newborn rat to block endogenous activity at opioid receptors in rostral and caudal parts of the CNS...
  13. MECHANISMS OF HIV-INDUCED ALTERATIONS IN SLEEP
    Mark Opp; Fiscal Year: 2000
    ..They will use rats instrumented with EEG electrodes, and chronic guide cannulae directed into lateral cerebral ventricles. Sleep-wake activity, and changes in cytokine mRNA expression in the CNS, will be determined after ..
  14. Modeling, Monitoring and Control of Hydrocephalus
    ANDREAS LINNINGER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  15. Multicenter Randomized Indomethacin IVH Prevention Trial
    Laura Ment; Fiscal Year: 2009
    ..Serial MRI scans will determine growth patterns of cortical regions across time. ..
  16. IDENTIFICATION & SELECTION OF ADULT NEURAL PRECURSORS
    Steven Goldman; Fiscal Year: 2003
    ..If this work is successful, we may soon need to consider how best to train newly generated networks of replacement neurons and glia to assume lost functions, in diseases as diverse as stroke, trauma, and the neurodegenerations. ..
  17. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009
    ....
  18. ADAPTIVE MECHANISMS OF DEVELOPING BRAIN
    Laura Ment; Fiscal Year: 2007
    ..If the central hypothesis of our program is verified, then novel therapeutic approaches for the reduction of neurodevelopmental deficits in preterm infants may result...
  19. Angiogenic determinants of endogenous adult neurogenesis
    Steven Goldman; Fiscal Year: 2008
    ....
  20. Regulation of adult human oligodendrocyte progenitors
    Steven Goldman; Fiscal Year: 2008
    ..abstract_text> ..
  21. CEREBELLAR STRUCTURE AND FUNCTION IN ALCOHOLISM
    Edith Sullivan; Fiscal Year: 2008
    ..abstract_text> ..
  22. NORMAL AGING OF BRAIN STRUCTURE AND FUNCTION
    EDITH VIONI SULLIVAN; Fiscal Year: 2010
    ..Initiate longitudinal 4-year follow-up data collection to test hypotheses regarding selective accelerated deterioration of frontally-based brain systems in normal aging. ..
  23. BIPOLAR DISORDER IN LATE LIFE
    John Beyer; Fiscal Year: 2009
    ..This research is unique and is likely to enhance our understanding of the phenomenology, course, outcome and relationship of MRI changes to the pathophysiology of bipolar disorder in late life. ..
  24. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2008
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
  25. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2006
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  26. NON-OPIOID ANALGESICS DERIVED FROM IMPROGAN
    LINDSAY HOUGH; Fiscal Year: 2006
    ..These experiments will help to discover the mechanism of action of this novel class of agents, and lead to the development of new pharmacotherapies for pain. ..
  27. In Vivo CSF Shunt Hydrodynamics in Hydrocephalus
    Marvin Bergsneider; Fiscal Year: 2010
    ..Documenting definitive evidence of the tuned-dynamic absorber model could have fundamental implications to all ICP disorders. ..
  28. Computational Modeling of High-Field MR Images
    Paul M Thompson; Fiscal Year: 2010
    ..We will share all images, protocols, and algorithms with our network of 100+ collaborating laboratories. ..
  29. HISTAMINERGIC MECHANISMS OF ANTINOCICEPTION
    LINDSAY HOUGH; Fiscal Year: 2009
    ..abstract_text> ..
  30. A Multidimensional Alzheimer's Disease Brain Atlas
    Paul M Thompson; Fiscal Year: 2010
    ..We will share all images, protocols, and algorithms with our 100+ collaborating laboratories. ..
  31. PEPTIDE REGULATION OF THE CHOROID PLEXUS-CSF SYSTEM
    Conrad Johanson; Fiscal Year: 2002
    ..Our long-term goal is to delineate the multifunctional roles of CP in brain fluid homeostasis. ..
  32. A HEMODYNAMIC MODEL OF INTRACRANIAL PRESSURE DYNAMICS
    Marvin Bergsneider; Fiscal Year: 2002
    ..An improved understanding of these disorders will offer new and better treatment modalities for millions of affected patients. ..
  33. Age-Related Decrease in A-Beta Peptide Clearance Pathways: CSF and BBB
    Conrad Earl Johanson; Fiscal Year: 2010
    ..Translation: Ap is an expedient marker to analyze aging effects on ISF-CSF relationships, and the compromised solute clearance by malfunctioning barrier systems. This sheds light on neurodegeneration. ..
  34. COR HONORS HIGH SCHOOL RESEARCH EDUCATION
    Joseph Dunbar; Fiscal Year: 2005
    ..abstract_text> ..
  35. ALCOHOL, HIV, AND THE BRAIN
    Adolf Pfefferbaum; Fiscal Year: 2004
    ..Specific Aim 3: To establish cross-sectional and longitudinal within-subject relationships among nueroimaging, neuropsychological, and clinical measures. ..
  36. Novel PDEs for Cortical Mapping and Analysis in Disease
    Paul Thompson; Fiscal Year: 2004
    ..abstract_text> ..
  37. White Matter Change and CNS Process in the Elderly
    Lisa Silbert; Fiscal Year: 2008
    ..This application proposes a structured didactic mentorship program for the principal investigator, Dr. Lisa Silbert, to ensure her independence as a clinical investigator at the end of the 5-year award period. [unreadable] [unreadable]..
  38. In Vivo Imaging of Post-Traumatic Cerebral Amyloid Deposition
    Marvin Bergsneider; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  39. Algorithms to Map Disease & Genetic Effects on the Brain
    Paul Thompson; Fiscal Year: 2005
    ..Validated on unique datasets, these tools will greatly empower biomedical studies that bridge imaging and genetics. They will help investigate the genetic transmission, triggers, and dynamics of disease in whole human populations. ..
  40. Pericytes in Pathogenesis of Germinal-Matrix Hemorrhage
    Praveen Ballabh; Fiscal Year: 2006
    ..Our data may help in understanding the etiology of GMH and may explain the basis of prenatal glucocorticoid therapy. It may also identify new strategies in the prevention and treatment of GMH. [unreadable] [unreadable]..
  41. Genetics of Chronic Kidney Disease
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  42. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  43. DRUG SENSITIVITY IN ELDERLY PSYCHIATRIC PATIENTS
    Ian Cook; Fiscal Year: 2002
    ..Cook will be well prepared to undertake independent and collaborative investigations, to expand his teaching roles, and to play a role in bridging basic science and clinical research within the Department. ..
  44. COHORT REGISTRY OF TYPE 1 DIABETES
    Mari Palta; Fiscal Year: 2010
    ..Findings on the predictive role of plasma lipids, body composition, insulin therapy and insulin resistance during adolescence could have important implications for prevention of diabetes complications. ..
  45. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2011
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
  46. Gross morphological correlates to the minicolumnopathy of autism
    Manuel F Casanova; Fiscal Year: 2010
    ..The intent is to develop markers of the condition that can be detected while the patient is alive. Another innovative aspect of the proposal is an attempt to validate current diagnostic screening techniques against autopsy findings. ..
  47. Neuroanatomy and Cognition in Velocardiofacial Syndrome
    Wendy Kates; Fiscal Year: 2005
    ....
  48. PHybrid Quadrupole/Orthogonal Time-of-Flight Mass Spec
    Kym Faull; Fiscal Year: 2002
    ..Reflecting this diversity of use, descriptions of the research of the major users of the instrument are provided...
  49. CELL MIGRATION AND CNS DEVELOPMENT ANOMALIES
    Jeffrey Golden; Fiscal Year: 2002
    ..abstract_text> ..
  50. EFFECTS OF EARLY-LIFE EXPERIENCE: ROLE OF CRH
    TALLIE BARAM; Fiscal Year: 2003
    ..Thus, these studies will set the stage for early intervention, with a promise of influencing the consequences of early-life experience on neurobiological correlates of stress throughout life. ..
  51. Developmental Affects of Ritalin on Brain
    TERESA MILNER; Fiscal Year: 2004
    ..Determining how therapeutic dosage regimens effect these transmitter systems is critical in understanding the safety of long-term therapeutic doses of MPH administered to children and adolescents with ADHD and other related disorders. ..
  52. Reduced Interneuronal Space in Schizophrenic Brains
    Manuel Casanova; Fiscal Year: 2005
    ..If our preliminary findings are corroborated, the smaller than normal minicolumns will demonstrate a reorganization of brain circuitry most probably defined during development. ..
  53. Silencing Hypothalamic Galanin with RNA Interference
    SuJean Choi; Fiscal Year: 2005
    ....
  54. Radiation Damage Repair in the Brain via Human ES cells
    Viviane Tabar; Fiscal Year: 2004
    ..If successful, we plan to initiate future studies addressing the functional impact of hES-derived neural precursor grafts on radiation-induced cognitive decline. This grant will only use the INIH-approved cell line: HI. NIH code WA01. ..
  55. PURCHASE OF MASS SPECTROMETRIC INSTRUMENTATION
    Kym Faull; Fiscal Year: 2001
    ..In addition to the role it plays in these research programs, the facility handles numerous routine LDMS analyses, further substantiating the importance of this new instrument to this campus. ..
  56. Behavior of Stem Cells in the Lesioned Aging Hippocampus
    Ashok Shetty; Fiscal Year: 2006
    ..abstract_text> ..
  57. Socially induced brain cells in adults: fate activity and regulation
    KENT DUNLAP; Fiscal Year: 2007
    ..This research seeks to identify specific features of social interaction that promote new neuron formation. [unreadable] [unreadable] [unreadable]..
  58. The VETSA Longitudinal Twin Study of Cortisol and Aging
    William Kremen; Fiscal Year: 2007
    ..Using multivariate twin analytic approaches, we will determine the extent of genetic, and shared and unique environmental factors influencing cortisol in midlife as well as their association with other key measures. ..
  59. CRF2 Receptor Modulation of Colonic Response to Stress
    MILLION MULUGETA; Fiscal Year: 2006
    ..abstract_text> ..
  60. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
    ..Successful completion of the proposed work will expand the knowledge base on brain mechanisms controlling bodily fluid homeostasis. ..
  61. Neuron Phenotype Changes During Lactation
    Gloria Hoffman; Fiscal Year: 2005
    ..abstract_text> ..
  62. The Brain & Psychosis: Asymmetry & cortical organization
    Martin Reite; Fiscal Year: 2005
    ..Altered tototopy and somatotopy will be examined as antecedents or results of psychosis. The findings will help identify individuals at risk for illness, and separate disease and psychosis-associated brain changes in mental disorders. ..
  63. Genetics of Microangiopathic Brain Injury
    Stephen T Turner; Fiscal Year: 2010
    ..abstract_text> ..
  64. RISK FACTORS FOR ATHEROGENESIS IN TYPE 1 DIABETES
    Mari Palta; Fiscal Year: 2003
    ..Such information is critical in directing further efforts toward primary prevention of atherosclerosis in individuals with Type 1 diabetes mellitus. ..
  65. RISK FACTORS IN BRONCHOPULMONARY DYSPLASIA
    Mari Palta; Fiscal Year: 2006
    ....
  66. Anthipertensive PharmacoGenomics
    Stephen Turner; Fiscal Year: 2006
    ..abstract_text> ..
  67. Normal Human and Schizophrenic Brain
    Manuel Casanova; Fiscal Year: 2004
    ..Another possible outcome is that the number of minicolumns in the temporal lobe may differ without a concomitant change in the structural reorganization. ..
  68. EFFECTS OF MISSPECIFICATION IN LONGITUDINAL MODELS
    Mari Palta; Fiscal Year: 2003
    ....
  69. fRMI Studies of Emotion and Cognition
    Bruce Wexler; Fiscal Year: 2007
    ..Both projects provide opportunities to develop and apply skills in measurement of inter-regional brain connectivity and in use of new analytic software. ..
  70. Modular Abnormalities of Brain Organization in Autism
    Manuel Casanova; Fiscal Year: 2007
    ..Treatment modalities, especially neuropharmaceutical agents, will prove more specific as their targets are better understood. ..
  71. fMRI of Cognitive Remediation Therapy in Schizophrenia
    Bruce Wexler; Fiscal Year: 2005
    ....