Summary: Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement.

Top Publications

  1. ncbi p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS
    Safa Al-Sarraj
    Department of Clinical Neuropathology, Kings College Hospital, Denmark Hill, London SE5 9RS, UK
    Acta Neuropathol 122:691-702. 2011
  2. ncbi Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies
    Catherine J Stoodley
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuroimage 44:489-501. 2009
  3. ncbi Neuroanatomy of autism
    David G Amaral
    The M I N D Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Trends Neurosci 31:137-45. 2008
  4. pmc Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing
    Catherine J Stoodley
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 175 Cambridge Street, Boston, MA 02114, USA
    Cortex 46:831-44. 2010
  5. ncbi Integration of quanta in cerebellar granule cells during sensory processing
    Paul Chadderton
    Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 428:856-60. 2004
  6. ncbi Consensus paper: roles of the cerebellum in motor control--the diversity of ideas on cerebellar involvement in movement
    Mario Manto
    Unité d Etude du Mouvement, FNRS, ULB Erasme, 808 Route de Lennik, Brussels, Belgium
    Cerebellum 11:457-87. 2012
  7. pmc Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors
    Brandon M Stell
    Department of Neurology, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:14439-44. 2003
  8. pmc Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity
    Fenna M Krienen
    Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Cereb Cortex 19:2485-97. 2009
  9. ncbi A probabilistic MR atlas of the human cerebellum
    Jorn Diedrichsen
    Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Adeilad Brigantia, University of Wales Bangor, Gwynedd LL572AS, UK
    Neuroimage 46:39-46. 2009
  10. ncbi The cerebellar microcircuit as an adaptive filter: experimental and computational evidence
    Paul Dean
    Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK
    Nat Rev Neurosci 11:30-43. 2010

Detail Information

Publications321 found, 100 shown here

  1. ncbi p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS
    Safa Al-Sarraj
    Department of Clinical Neuropathology, Kings College Hospital, Denmark Hill, London SE5 9RS, UK
    Acta Neuropathol 122:691-702. 2011
    ..of TDP-43 proteinopathy patients who have unusual and abundant p62 positive, TDP-43 negative inclusions in the cerebellum and hippocampus...
  2. ncbi Functional topography in the human cerebellum: a meta-analysis of neuroimaging studies
    Catherine J Stoodley
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuroimage 44:489-501. 2009
    Clinical, experimental and neuroimaging studies indicate that the cerebellum is involved in neural processes beyond the motor domain...
  3. ncbi Neuroanatomy of autism
    David G Amaral
    The M I N D Institute, Department of Psychiatry and Behavioral Sciences, University of California, Davis, 2825 50th Street, Sacramento, CA 95817, USA
    Trends Neurosci 31:137-45. 2008
    ..Postmortem and structural magnetic resonance imaging studies have highlighted the frontal lobes, amygdala and cerebellum as pathological in autism. However, there is no clear and consistent pathology that has emerged for autism...
  4. pmc Evidence for topographic organization in the cerebellum of motor control versus cognitive and affective processing
    Catherine J Stoodley
    Ataxia Unit, Cognitive Behavioral Neurology Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 175 Cambridge Street, Boston, MA 02114, USA
    Cortex 46:831-44. 2010
    ..We have hypothesized that there is topographic organization in the human cerebellum such that the anterior lobe and lobule VIII contain the representation of the sensorimotor cerebellum; lobules ..
  5. ncbi Integration of quanta in cerebellar granule cells during sensory processing
    Paul Chadderton
    Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK
    Nature 428:856-60. 2004
    ..In the cerebellum, granule cells constitute the input layer, translating mossy fibre signals into parallel fibre input to Purkinje ..
  6. ncbi Consensus paper: roles of the cerebellum in motor control--the diversity of ideas on cerebellar involvement in movement
    Mario Manto
    Unité d Etude du Mouvement, FNRS, ULB Erasme, 808 Route de Lennik, Brussels, Belgium
    Cerebellum 11:457-87. 2012
    ..While the field has yet to reach a consensus on the precise role played by the cerebellum in movement control, the literature has witnessed the emergence of broad proposals that address cerebellar ..
  7. pmc Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors
    Brandon M Stell
    Department of Neurology, The David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:14439-44. 2003
    ..Recognition that delta subunit-containing GABAARs responsible for a tonic conductance are a preferential target for neuroactive steroids may lead to novel pharmacological approaches for the treatment of these common conditions...
  8. pmc Segregated fronto-cerebellar circuits revealed by intrinsic functional connectivity
    Fenna M Krienen
    Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Cereb Cortex 19:2485-97. 2009
    ..Direct comparison of right- and left-seeded frontal regions revealed contralateral lateralization in the cerebellum for each of the segregated circuits...
  9. ncbi A probabilistic MR atlas of the human cerebellum
    Jorn Diedrichsen
    Wolfson Centre for Cognitive and Clinical Neuroscience, School of Psychology, Adeilad Brigantia, University of Wales Bangor, Gwynedd LL572AS, UK
    Neuroimage 46:39-46. 2009
    The functional organization of the cerebellum is reflected in large part by the unique afferent and efferent connectivity of the individual cerebellar lobules...
  10. ncbi The cerebellar microcircuit as an adaptive filter: experimental and computational evidence
    Paul Dean
    Department of Psychology, University of Sheffield, Western Bank, Sheffield, S10 2TP, UK
    Nat Rev Neurosci 11:30-43. 2010
    ..This congruence suggests that insights from adaptive-filter theory might help to address outstanding issues of cerebellar function, including both microcircuit processing and extra-cerebellar connectivity...
  11. pmc Functional topography of the cerebellum for motor and cognitive tasks: an fMRI study
    Catherine J Stoodley
    Cognitive Behavioral Neurology Unit, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Neuroimage 59:1560-70. 2012
    Anatomical, clinical and imaging findings suggest that the cerebellum is engaged in cognitive and affective functions as well as motor control...
  12. pmc Consensus paper: pathological role of the cerebellum in autism
    S Hossein Fatemi
    University of Minnesota Medical School, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cerebellum 11:777-807. 2012
    There has been significant advancement in various aspects of scientific knowledge concerning the role of cerebellum in the etiopathogenesis of autism...
  13. ncbi Mitochondrial fusion protects against neurodegeneration in the cerebellum
    Hsiuchen Chen
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Cell 130:548-62. 2007
    ..However, the cellular basis underlying this relationship is poorly understood. By removing Mfn2 from the cerebellum, we established a model for neurodegeneration caused by loss of mitochondrial fusion...
  14. ncbi Channel-mediated tonic GABA release from glia
    Soojung Lee
    Center for Neural Science, Korea Institute of Science and Technology KIST, Seoul, Korea
    Science 330:790-6. 2010
    ..Here we report that tonic inhibition in the cerebellum is due to GABA being released from glial cells by permeation through the Bestrophin 1 (Best1) anion channel...
  15. ncbi Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog
    R J Wechsler-Reya
    Department of Developmental Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, California 94305, USA
    Neuron 22:103-14. 1999
    ..Blocking Shh function in vivo dramatically reduces GCP proliferation. These findings provide insight into the mechanisms of normal growth and tumorigenesis in the cerebellum.
  16. ncbi Cerebellar circuitry as a neuronal machine
    Masao Ito
    RIKEN Brain Science Institute, Wako, Saitama, Japan
    Prog Neurobiol 78:272-303. 2006
    ..the 1963 Nobel Prize in physiology/medicine, he opened another chapter of neuroscience with his work on the cerebellum. From 1963 to 1967, Eccles and his colleagues in Canberra successfully dissected the complex neuronal circuitry ..
  17. ncbi Structural and quantitative studies on the normal C3H and Lurcher mutant mouse
    K W Caddy
    Philos Trans R Soc Lond B Biol Sci 287:167-201. 1979
  18. ncbi Timing and plasticity in the cerebellum: focus on the granular layer
    Egidio D'Angelo
    Department of Cellular and Molecular Physiological and Pharmacological Sciences, University of Pavia and CNISM, Via Forlanini 6, I 27100 Pavia, Italy
    Trends Neurosci 32:30-40. 2009
    Two of the most striking properties of the cerebellum are its control in timing of motor operations and its ability to adapt behavior to new sensorimotor associations...
  19. ncbi The effect of filter size on VBM analyses of DT-MRI data
    Derek K Jones
    Neuroimaging Research Group, Centre for Neuroimaging Sciences, Institute of Psychiatry, London, UK
    Neuroimage 26:546-54. 2005
    ..ii) reduced FA in right superior temporal gyrus (STG) in patients; (iii) reduced FA in both right STG and left cerebellum in patients; and (iv) reduced FA only in left cerebellum in patients...
  20. ncbi The cerebellum and cognition: evidence from functional imaging studies
    Catherine J Stoodley
    Department of Psychology, American University, 4400 Massachusetts Avenue NW, Washington, DC 20016, USA
    Cerebellum 11:352-65. 2012
    Evidence for a role of the human cerebellum in cognitive functions comes from anatomical, clinical and neuroimaging data...
  21. pmc IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation
    Hongen Wei
    Department of Neurochemistry, NY State Institute for Basic Research in Developmental Disabilities, New York, USA
    J Neuroinflammation 8:52. 2011
    ..Recent evidence shows that IL-6 has a crucial role in the development and plasticity of CNS...
  22. ncbi Cerebellar loops with motor cortex and prefrontal cortex of a nonhuman primate
    Roberta M Kelly
    Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 23:8432-44. 2003
    ..Thus, our observations suggest that multiple closed-loop circuits represent a fundamental architectural feature of cerebrocerebellar interactions...
  23. ncbi Purkinje cells originate from cerebellar ventricular zone progenitors positive for Neph3 and E-cadherin
    Eri Mizuhara
    Group for Neuronal Differentiation, KAN Research Institute Inc, Kobe, Hyogo 650 0047, Japan
    Dev Biol 338:202-14. 2010
    ..Using FACS, Neph3(+) GABAergic progenitors were sorted from the embryonic cerebellum, and the cell fate of this population was mapped by culturing in vitro...
  24. pmc Ascl1 genetics reveals insights into cerebellum local circuit assembly
    Anamaria Sudarov
    Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA
    J Neurosci 31:11055-69. 2011
    Two recently generated targeted mouse alleles of the neurogenic gene Ascl1 were used to characterize cerebellum circuit formation...
  25. ncbi Math1 is essential for genesis of cerebellar granule neurons
    N Ben-Arie
    Department of Molecular and Human Genetics, Howard Hughes Medical Institute, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 390:169-72. 1997
    The cerebellum is essential for fine motor control of movement and posture, and its dysfunction disrupts balance and impairs control of speech, limb and eye movements...
  26. ncbi Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance
    S G Brickley
    Department of Pharmacology, University College London, London WC1E 6BT, UK
    Nature 409:88-92. 2001
  27. ncbi Anatomical and physiological foundations of cerebellar information processing
    Richard Apps
    Sensorimotor Control Group, Department of Physiology, University of Bristol, University Walk, Bristol BS8 1TD, UK
    Nat Rev Neurosci 6:297-311. 2005
    ..of spinocerebellar interactions in which the structure-functional organizing principle is a division of the cerebellum into discrete microcomplexes...
  28. pmc Distinct cerebellar contributions to intrinsic connectivity networks
    Christophe Habas
    Service de NeuroImagerie, Hôpital des Quinze Vingts, Universite Pierre et Marie Curie Paris 6, 75012 Paris, France
    J Neurosci 29:8586-94. 2009
    ..To better define this distinct functional anatomy, in the current study we delineate the role of the cerebellum in several nonmotor systems simultaneously and in the same subjects using resting state functional connectivity ..
  29. ncbi Math1 expression redefines the rhombic lip derivatives and reveals novel lineages within the brainstem and cerebellum
    Vincent Y Wang
    Program in Developmental Biology, Baylor College of Medicine, Houston, Texas 77030, USA
    Neuron 48:31-43. 2005
  30. ncbi Central cancellation of self-produced tickle sensation
    S J Blakemore
    Wellcome Department of Cognitive Neurology, London, UK
    Nat Neurosci 1:635-40. 1998
    ..More activity was found in somatosensory cortex when the stimulus was externally produced. In the cerebellum, less activity was associated with a movement that generated a tactile stimulus than with a movement that did ..
  31. ncbi Sonic hedgehog regulates the growth and patterning of the cerebellum
    N Dahmane
    The Skirball Institute, Developmental Genetics Program and Department of Cell Biology, NYU School of Medicine, New York, NY 10016, USA
    Development 126:3089-100. 1999
    ..Here we show that Sonic hedgehog (Shh) signaling controls the development of the cerebellum at multiple levels...
  32. ncbi Receptive field plasticity profoundly alters the cutaneous parallel fiber synaptic input to cerebellar interneurons in vivo
    Henrik Jörntell
    Department of Physiological Sciences, Section for Neurophysiology, SE 221 84 Lund, Sweden
    J Neurosci 23:9620-31. 2003
    ..The CF response, which is crucial for the induction of the PF synaptic potentiation, was strong but variable and very different from the conventional EPSPs evoked by PFs...
  33. ncbi The neural representation of time
    Richard B Ivry
    3210 Tolman Hall, Department of Psychology, University of California, Berkeley, California 94720 1650 USA
    Curr Opin Neurobiol 14:225-32. 2004
    ..Consistent with the specialized system framework, the cerebellum is associated with various tasks that require precise timing...
  34. ncbi Trans-synaptic interaction of GluRdelta2 and Neurexin through Cbln1 mediates synapse formation in the cerebellum
    Takeshi Uemura
    Department of Molecular Neurobiology and Pharmacology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Cell 141:1068-79. 2010
    ..These results suggest that GluRdelta2 mediates cerebellar synapse formation by interacting with presynaptic NRXNs through Cbln1...
  35. ncbi Stargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
    L Chen
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143, USA
    Nature 408:936-43. 2000
  36. ncbi Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum
    Mikio Hoshino
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuron 47:201-13. 2005
    ..Our results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum.
  37. ncbi Human cerebellar activity reflecting an acquired internal model of a new tool
    H Imamizu
    JST ERATO Kawato Dynamic Brain Project, Soraku gun, Kyoto, Japan
    Nature 403:192-5. 2000
    ..Because the human cerebellum is involved in higher cognitive function as well as in motor control, we propose a coherent computational theory ..
  38. pmc Updated energy budgets for neural computation in the neocortex and cerebellum
    Clare Howarth
    Brain Research Centre, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada
    J Cereb Blood Flow Metab 32:1222-32. 2012
    ..The majority of cerebellar signaling energy use is on the maintenance of resting potentials (54%) and postsynaptic receptors (22%), while action potentials account for only 17% of the signaling energy use...
  39. ncbi Spatiotemporal firing patterns in the cerebellum
    Chris I De Zeeuw
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Rev Neurosci 12:327-44. 2011
    ..Here, we review expanding lines of evidence that such spatiotemporal coding occurs in the cerebellum, and that the olivocerebellar system is optimally designed to generate and employ precise patterns of complex ..
  40. ncbi Sensory prediction errors drive cerebellum-dependent adaptation of reaching
    Ya weng Tseng
    Dept of Neurology, The Johns Hopkins School of Medicine, Kennedy Krieger Institute, Baltimore, MD 21205, USA
    J Neurophysiol 98:54-62. 2007
    The cerebellum is an essential part of the neural network involved in adapting goal-directed arm movements. This adaptation might rely on two distinct signals: a sensory prediction error or a motor correction...
  41. pmc The organization of the human cerebellum estimated by intrinsic functional connectivity
    Randy L Buckner
    Howard Hughes Medical Institute, Cambridge, Massachusetts, USA
    J Neurophysiol 106:2322-45. 2011
    The cerebral cortex communicates with the cerebellum via polysynaptic circuits. Separate regions of the cerebellum are connected to distinct cerebral areas, forming a complex topography...
  42. pmc Reevaluating the role of LTD in cerebellar motor learning
    Martijn Schonewille
    Department of Neuroscience, Dr Molewaterplein 50, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Neuron 70:43-50. 2011
    ..These findings demonstrate that PF-PC LTD is not essential for cerebellar motor learning...
  43. pmc Decreased connectivity and cerebellar activity in autism during motor task performance
    Stewart H Mostofsky
    Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Brain 132:2413-25. 2009
    ..associated with motor execution [contralateral primary sensorimotor cortex, contralateral thalamus, ipsilateral cerebellum, supplementary motor area (SMA)]; however, the TD group showed greater activation in the ipsilateral anterior ..
  44. pmc Dissociating the roles of the cerebellum and motor cortex during adaptive learning: the motor cortex retains what the cerebellum learns
    Joseph M Galea
    Department of Physical Medicine and Rehabilitation, Johns Hopkins Medical Institution, Baltimore, MD 21231, USA
    Cereb Cortex 21:1761-70. 2011
    ..in the processes of acquisition and retention during adaptive motor learning and demonstrate that the cerebellum and primary motor cortex have distinct functional roles...
  45. ncbi Integration of sensory and motor representations of single fingers in the human cerebellum
    Tobias Wiestler
    Institute of Cognitive Neuroscience, University College London, London, United Kingdom
    J Neurophysiol 105:3042-53. 2011
    The cerebellum is thought to play a key role in the integration of sensory and motor events. Little is known, however, about how sensory and motor maps in the cerebellum superimpose...
  46. ncbi Involvement of cerebellum in emotional behavior
    P Strata
    National Institute of Neuroscience Italy, University of Turin, Turin, Italy
    Physiol Res 60:S39-48. 2011
    In the last decade a growing body of data revealed that the cerebellum is involved in the regulation of the affective reactions as well as in forming the association between sensory stimuli and their emotional values...
  47. ncbi Properties of somatosensory synaptic integration in cerebellar granule cells in vivo
    Henrik Jörntell
    Department of Experimental Medical Sciences, Section for Neuroscience, Biomedical Center F10, SE 221 84 Lund, Sweden
    J Neurosci 26:11786-97. 2006
  48. pmc The basal ganglia communicate with the cerebellum
    Andreea C Bostan
    Department of Neurobiology, University of Pittsburgh School of Medicine, Center for the Neural Basis of Cognition, Systems Neuroscience Institute, Pittsburgh, PA 15261, USA
    Proc Natl Acad Sci U S A 107:8452-6. 2010
    The basal ganglia and cerebellum are major subcortical structures that influence not only movement, but putatively also cognition and affect. Both structures receive input from and send output to the cerebral cortex...
  49. ncbi Cerebellum and nonmotor function
    Peter L Strick
    Veterans Affairs Medical Center, Pittsburgh, Pennsylvania 15261, USA
    Annu Rev Neurosci 32:413-34. 2009
    Does the cerebellum influence nonmotor behavior? Recent anatomical studies demonstrate that the output of the cerebellum targets multiple nonmotor areas in the prefrontal and posterior parietal cortex, as well as the cortical motor areas...
  50. pmc Cerebellum development during childhood and adolescence: a longitudinal morphometric MRI study
    Henning Tiemeier
    Child Psychiatry Branch, National Institute of Mental Health NIH, Bethesda, MD 20892, USA
    Neuroimage 49:63-70. 2010
    In addition to its well-established role in balance, coordination, and other motor skills, the cerebellum is increasingly recognized as a prominent contributor to a wide array of cognitive and emotional functions...
  51. ncbi Cerebral and cerebellar gray matter reduction in first-episode patients with major depressive disorder: a voxel-based morphometry study
    Jing Peng
    Department of Radiology, Xuanwu Hospital of Capital Medical University, No 45, Chang Chun St, Xuanwu District, Beijing 100053, China
    Eur J Radiol 80:395-9. 2011
    ..To investigate cerebral and cerebellar gray matter abnormalities in patients with first-episode major depressive disorder (MDD)...
  52. pmc Genomic convergence analysis of schizophrenia: mRNA sequencing reveals altered synaptic vesicular transport in post-mortem cerebellum
    Joann Mudge
    National Center for Genome Resources, Santa Fe, NM, USA
    PLoS ONE 3:e3625. 2008
    ..Twenty three genes with altered expression and involvement in presynaptic vesicular transport, Golgi function and GABAergic neurotransmission define a unifying molecular hypothesis for dysfunction in cerebellar cortex in SCZ...
  53. ncbi A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
    Takeharu Nagai
    Laboratory for Cell Function and Dynamics, Advanced Technology Development Center, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako City, Saitama, 351 0198, Japan
    Nat Biotechnol 20:87-90. 2002
    ..With the improved speed and efficiency of maturation and the increased resistance to environment, Venus will enable fluorescent labelings that were not possible before...
  54. ncbi Role of olivary electrical coupling in cerebellar motor learning
    Ruben S Van Der Giessen
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Neuron 58:599-612. 2008
  55. pmc Distinct and overlapping functional zones in the cerebellum defined by resting state functional connectivity
    Jill X O'Reilly
    FMRIB Centre, Department of Clinical Neurology, University of Oxford, OX1 9DU Oxford, UK
    Cereb Cortex 20:953-65. 2010
    The cerebellum processes information from functionally diverse regions of the cerebral cortex. Cerebellar input and output nuclei have connections with prefrontal, parietal, and sensory cortex as well as motor and premotor cortex...
  56. ncbi Effects of age on tissues and regions of the cerebrum and cerebellum
    T L Jernigan
    Veterans Affairs San Diego Healthcare System, San Diego, CA, USA
    Neurobiol Aging 22:581-94. 2001
    ..Age was related to estimated volumes of: gray matter, white matter, and CSF of the cerebrum and cerebellum; gray matter, white matter, white matter abnormality, and CSF within each cerebral lobe; and gray matter of ..
  57. ncbi Multiple climbing fibers signal to molecular layer interneurons exclusively via glutamate spillover
    German Szapiro
    Laboratoire de Neurobiologie, Ecole Normale Superieure, CNRS, 46 rue d Ulm, 75005 Paris, France
    Nat Neurosci 10:735-42. 2007
    ..Climbing fibers are known to direct parallel fiber synaptic plasticity in interneurons, so one function of this spillover is likely to involve controlling synaptic plasticity...
  58. ncbi Reorganization and plasticity in the adult brain during learning of motor skills
    Julien Doyon
    Functional Neuroimaging Unit, University of Montreal Geriatric Institute, 4565, Queen Mary Street, Montreal, Quebec, H3W 1W5, Canada
    Curr Opin Neurobiol 15:161-7. 2005
    ..There has been recent behavioral, lesion and additional neuroimaging studies that have addressed the assumptions made in this theory that will help in the revision of this model...
  59. pmc NeuroD is required for differentiation of the granule cells in the cerebellum and hippocampus
    T Miyata
    Department of Molecular, Cellular, and Developmental Biology, University of Colorado at Boulder, Boulder, Colorado 80309 0347, USA
    Genes Dev 13:1647-52. 1999
    ..to adulthood but display severe neurological phenotype due to neuronal deficit in the granule layers of the cerebellum and hippocampus...
  60. ncbi Cerebellum activation associated with performance change but not motor learning
    R D Seidler
    Brain Sciences Center 11B, Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Science 296:2043-6. 2002
    The issue of whether the cerebellum contributes to motor skill learning is controversial, principally because of the difficulty of separating the effects of motor learning from changes in performance...
  61. ncbi Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development
    K R Thomas
    Howard Hughes Medical Institute, Department of Biology and Human Genetics, Salt Lake City, Utah 84112
    Nature 346:847-50. 1990
    ..The latter pathology in mice and humans is often associated with defects in the cerebellum. Examination of int-1-/int-1- mice at several stages of embryogenesis revealed severe abnormalities in the ..
  62. pmc Dendritic calcium signaling triggered by spontaneous and sensory-evoked climbing fiber input to cerebellar Purkinje cells in vivo
    Kazuo Kitamura
    Wolfson Institute for Biomedical Research and Department of Neuroscience, Physiology, and Pharmacology, University College London, Gower Street, London WC1E 6BT, UK
    J Neurosci 31:10847-58. 2011
  63. ncbi GABAergic and glutamatergic modulation of spontaneous and motor-cortex-evoked complex spike activity
    Eric J Lang
    Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York 10016, USA
    J Neurophysiol 87:1993-2008. 2002
  64. ncbi The role of the cerebellum in cognition and emotion: personal reflections since 1982 on the dysmetria of thought hypothesis, and its historical evolution from theory to therapy
    Jeremy D Schmahmann
    Ataxia Unit, Laboratory for Neuroanatomy and Cerebellar Neurobiology, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Neuropsychol Rev 20:236-60. 2010
    The cognitive neuroscience of the cerebellum is now an established multidisciplinary field of investigation...
  65. pmc Stoichiometry of base excision repair proteins correlates with increased somatic CAG instability in striatum over cerebellum in Huntington's disease transgenic mice
    Agathi Vassiliki Goula
    Department of Neurobiology and Genetics, Institute of Genetics and Molecular and Cellular Biology, UMR 7104 CNRS INSERM UdS, Illkirch, France
    PLoS Genet 5:e1000749. 2009
    ..that preferentially degenerates in HD, is highly unstable, whereas it is rather stable in the disease-spared cerebellum. The mechanisms underlying the age-dependence and tissue-specificity of somatic CAG instability remain obscure...
  66. ncbi Loss of autophagy in the central nervous system causes neurodegeneration in mice
    Masaaki Komatsu
    Laboratory of Frontier Science, Tokyo Metropolitan Institute of Medical Science, Bunkyo ku, Tokyo 113 8613, Japan
    Nature 441:880-4. 2006
    ..Our results indicate that autophagy is essential for the survival of neural cells, and that impairment of autophagy is implicated in the pathogenesis of neurodegenerative disorders involving ubiquitin-containing inclusion bodies...
  67. ncbi Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice
    A Aiba
    Howard Hughes Medical Institute, Center for Learning and Memory, Cambridge, Massachusetts
    Cell 79:377-88. 1994
    ..The anatomy of the cerebellum is not overtly disturbed...
  68. pmc Complex epigenetic regulation of engrailed-2 (EN-2) homeobox gene in the autism cerebellum
    S J James
    Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children s Hospital Research Institute, Little Rock, AR 72202, USA
    Transl Psychiatry 3:e232. 2013
  69. ncbi Math1 is expressed in temporally discrete pools of cerebellar rhombic-lip neural progenitors
    Rob Machold
    Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, 540 First Avenue, New York, New York 10016, USA
    Neuron 48:17-24. 2005
    ..labeled: first, ones that give rise to granule cells that predominantly populate the anterior lobes of the adult cerebellum and later, those that populate progressing more caudally lobes until labeling of all granule cell precursors is ..
  70. ncbi Early fetal development of the human cerebellum
    Kwang Ho Cho
    Department of Neurology, Wonkwang University School of Medicine, Institute of Wonkwang Medical Science, 344 2 Sinyong dong, Iksan, Jeonbuk, Korea
    Surg Radiol Anat 33:523-30. 2011
    Early cerebellum development in humans is poorly understood...
  71. ncbi Cognition, emotion and the cerebellum
    Jeremy D Schmahmann
    Ataxia Unit, Massachusetts General Hospital Boston, MA, USA
    Brain 129:290-2. 2006
  72. pmc Specific regions within the embryonic midbrain and cerebellum require different levels of FGF signaling during development
    M Albert Basson
    Department of Anatomy and Program in Developmental Biology, University of California San Francisco, CA 94158, USA
    Development 135:889-98. 2008
    Prospective midbrain and cerebellum formation are coordinated by FGF ligands produced by the isthmic organizer. Previous studies have suggested that midbrain and cerebellum development require different levels of FGF signaling...
  73. ncbi The isthmic organizer signal FGF8 is required for cell survival in the prospective midbrain and cerebellum
    Candace L Chi
    Department of Anatomy and Program in Developmental Biology, School of Medicine, University of California at San Francisco, San Francisco, CA 94143 0452, USA
    Development 130:2633-44. 2003
    Numerous studies have demonstrated that the midbrain and cerebellum develop from a region of the early neural tube comprising two distinct territories known as the mesencephalon (mes) and rostral metencephalon (met; rhombomere 1), ..
  74. pmc Sensory transmission in cerebellar granule cells relies on similarly coded mossy fiber inputs
    Fredrik Bengtsson
    Section for Neurophysiology, BMC F10, Tornavagen 10, SE 221 84 Lund, Sweden
    Proc Natl Acad Sci U S A 106:2389-94. 2009
    ..The computational consequences of this are that it becomes possible for granule cells to also transmit weak sensory inputs in a graded fashion and to preserve the specific activity patterns of the mossy fibers...
  75. ncbi Complementary roles of basal ganglia and cerebellum in learning and motor control
    K Doya
    Information Sciences Division, ATR International and CREST, Japan Science and Technology Corporation, 2 2 2 Hikaridai, Seika, Soraku, 619 0288, Kyoto, Japan
    Curr Opin Neurobiol 10:732-9. 2000
    The classical notion that the basal ganglia and the cerebellum are dedicated to motor control has been challenged by the accumulation of evidence revealing their involvement in non-motor, cognitive functions...
  76. ncbi The cerebellum and neural networks for rhythmic sensorimotor synchronization in the human brain
    Marco Molinari
    Experimental Neurorehabilitation Lab, I R C C S Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
    Cerebellum 6:18-23. 2007
    ..In the present review we will focus on the role of the cerebellum by referring to the general modeling of SMS functioning...
  77. pmc Reliable coding emerges from coactivation of climbing fibers in microbands of cerebellar Purkinje neurons
    Ilker Ozden
    Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 29:10463-73. 2009
    ..Given the anatomy of the olivocerebellar system, microband synchrony may shape the output of neurons in the cerebellar nuclei either via powerful inhibition by Purkinje cells or by direct monosynaptic excitation from the inferior olive...
  78. ncbi The cerebellum in emotion regulation: a repetitive transcranial magnetic stimulation study
    Dennis J L G Schutter
    Experimental Psychology, Helmholtz Research Institute, Utrecht University, Utrecht, The Netherlands
    Cerebellum 8:28-34. 2009
    Several lines of evidence suggest that the cerebellum may play a role in the regulation of emotion...
  79. pmc Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency
    Catherine Coffinier
    Departments of Medicine and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:5076-81. 2010
    ..brain abnormalities resembling lissencephaly, with abnormal layering of neurons in the cerebral cortex and cerebellum. This neuronal layering abnormality is due to defective neuronal migration, a process that is dependent on the ..
  80. ncbi Control of mental activities by internal models in the cerebellum
    Masao Ito
    Masao Ito is at the RIKEN Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198, Japan
    Nat Rev Neurosci 9:304-13. 2008
    The intricate neuronal circuitry of the cerebellum is thought to encode internal models that reproduce the dynamic properties of body parts...
  81. ncbi Neurogenesis in the cerebellum
    Barbara Carletti
    Department of Neuroscience and Rita Levi Montalcini Centre for Brain Repair, National Institute of Neuroscience, University of Turin, Italy
    Neuroscientist 14:91-100. 2008
    ..discuss the fate mapping studies with other new information stemming from transplantation experiments, in an effort to link the developmental potential of neural progenitor populations of the cerebellum with their spatio-temporal origin.
  82. ncbi Symbolic representations of action in the human cerebellum
    J H Balsters
    Department of Psychology, Royal Holloway, University of London, Egham, Surrey, UK
    Neuroimage 43:388-98. 2008
    ..Here, we test the hypothesis that the prefrontal-projecting zones in the human cerebellum process the abstract content of information embedded within sensory cues...
  83. ncbi Close correlation between the birth date of Purkinje cells and the longitudinal compartmentalization of the mouse adult cerebellum
    Kazunori Namba
    Hashimoto Research Unit, RIKEN BSI, Saitama 351 0198, Japan
    J Comp Neurol 519:2594-614. 2011
    The adult cerebellum is organized into longitudinal compartments that are revealed by specific axonal projections (olivocerebellar and corticonuclear projections)...
  84. ncbi Increase in cerebellar neurotrophin-3 and oxidative stress markers in autism
    Elizabeth M Sajdel-Sulkowska
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    Cerebellum 8:366-72. 2009
    ..In the present study, we further explored oxidative damage in the autistic cerebellum by measuring 8-hydroxydeoxyguanosine (8-OH-dG), a marker of DNA modification, in a subset of cases analyzed for ..
  85. ncbi A review of differences between basal ganglia and cerebellar control of movements as revealed by functional imaging studies
    M Jueptner
    Department of Psychiatry, University Clinics, Essen, Germany
    Brain 121:1437-49. 1998
    The role of the basal ganglia and cerebellum in the control of movements is unclear. We summarize results from three groups of PET studies of regional CBF...
  86. ncbi Maturation of EPSCs and intrinsic membrane properties enhances precision at a cerebellar synapse
    Laurence Cathala
    Department of Pharmacology, University College London, London WC1E 6BT, United Kingdom
    J Neurosci 23:6074-85. 2003
    ..We suggest that these concurrent developmental changes, which increase the temporal precision of EPSP-spike coupling, will increase the fidelity with which sensory information is processed within the input layer of the cerebellar cortex...
  87. pmc Transcriptional profiling of intrinsic PNS factors in the postnatal mouse
    Robin P Smith
    The Miami Project to Cure Paralysis, Department of Neurological Surgery, Miller School of Medicine, University of Miami, 1400 NW 12th Ave, Miami, FL 33136, USA
    Mol Cell Neurosci 46:32-44. 2011
    ..Real-time PCR and immunohistochemical studies confirmed that one representative TF, STAT3, is intrinsic to PNS neurons, and that constitutively active STAT3 is sufficient to promote CGN neurite outgrowth...
  88. ncbi Translocation of a "winner" climbing fiber to the Purkinje cell dendrite and subsequent elimination of "losers" from the soma in developing cerebellum
    Kouichi Hashimoto
    Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
    Neuron 63:106-18. 2009
    ..In newborn mouse cerebellum, each Purkinje cell (PC) is innervated by multiple climbing fibers (CFs) with similar strengths...
  89. pmc The basal ganglia and cerebellum interact in the expression of dystonic movement
    Vladimir K Neychev
    Department of Neurology, Johns Hopkins University, Baltimore, MD 21287, USA
    Brain 131:2499-509. 2008
    ..of dystonic movements depends on influences from a motor network that includes both the basal ganglia and cerebellum. The first strategy was to evaluate the consequences of subthreshold lesions of the striatum in two different ..
  90. pmc Trio is a key guanine nucleotide exchange factor coordinating regulation of the migration and morphogenesis of granule cells in the developing cerebellum
    Ya Jing Peng
    Model Animal Research Center and MOE Key Laboratory of Model Animal for Disease Study, Nanjing University, Nanjing 210061, China
    J Biol Chem 285:24834-44. 2010
    ..Trio may serve as a signal integrator decoding extrinsic signals to Rho GTPases for cytoskeleton organization...
  91. ncbi Should I stay or should I go? Becoming a granule cell
    Alain Chedotal
    Institut National de la Sante et de la Recherche Medicale INSERM, UMR S968, Institut de la Vision, Department of Development, F 75012 Paris, France
    Trends Neurosci 33:163-72. 2010
    ..These studies suggest that a major reorganization of the cytoskeleton occurs as granule cells switch from tangential to radial migration...
  92. ncbi Complementary stripes of phospholipase Cbeta3 and Cbeta4 expression by Purkinje cell subsets in the mouse cerebellum
    Justyna R Sarna
    Department of Cell Biology and Anatomy, Genes and Development Research Group, Faculty of Medicine, The University of Calgary, Alberta, Canada
    J Comp Neurol 496:303-13. 2006
    ..The data reveal that both phospholipase Cbeta isotypes are expressed strongly in the mouse cerebellum in subsets of Purkinje cells. The two distributions are distinct and largely nonoverlapping...
  93. ncbi Neuronal position in the developing brain is regulated by mouse disabled-1
    B W Howell
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Nature 389:733-7. 1997
    ..of the mouse disabled1 (mdab1) gene disturbs neuronal layering in the cerebral cortex, hippocampus and cerebellum. The gene encodes a cytoplasmic protein, mDab1 p80, which is expressed and tyrosine-phosphorylated in the ..
  94. ncbi The magnocellular theory of developmental dyslexia
    J Stein
    University Laboratory of Physiology, Oxford, UK
    Dyslexia 7:12-36. 2001
    ..The cerebellum is the head ganglion of magnocellular systems; it contributes to binocular fixation and to inner speech for ..
  95. ncbi Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer
    Keiko Matsuda
    Department of Physiology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Science 328:363-8. 2010
    ..with exogenously applied Cbln1, was necessary and sufficient to induce new synapses in vitro and in the adult cerebellum in vivo...
  96. ncbi Pallidal dysfunction drives a cerebellothalamic circuit into Parkinson tremor
    Rick C Helmich
    Donders Institute for Brain, Cognition, and Behavior, Center for Cognitive NeuroImaging, Radboud University Nijmegen, The Netherlands
    Ann Neurol 69:269-81. 2011
    ..Instead, resting tremor is associated with increased activity in a distinct cerebellothalamic circuit. To date, it remains unknown how the interplay between basal ganglia and the cerebellothalamic circuit can result in resting tremor...
  97. ncbi Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    K H Herzog
    Department of Developmental Neurobiology, St Jude Children s Research Hospital, 332 North Lauderdale, Memphis, TN 38101, USA
    Science 280:1089-91. 1998
    ..This lack of death occurred in diverse regions of the CNS, including the cerebellum, which is markedly affected in AT...
  98. ncbi Novel GABAA receptor alpha subunit is expressed only in cerebellar granule cells
    K Kato
    MRC Molecular Genetics Unit, Cambridge, England
    J Mol Biol 214:619-24. 1990
    ..This is the first demonstration of the exclusive presence of a neuroreceptor subtype in a single neuronal cell type...
  99. ncbi 'New' functions for 'old' proteins: the role of the calcium-binding proteins calbindin D-28k, calretinin and parvalbumin, in cerebellar physiology. Studies with knockout mice
    Beat Schwaller
    Institute of Histology and General Embryology, University of Fribourg, Fribourg, Switzerland
    Cerebellum 1:241-58. 2002
    ..Here, we review the biology of these calcium-binding proteins with distinct reference to the cerebellum, since they are particularly enriched in specific cerebellar neurons...
  100. pmc Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool
    N Spassky
    Universite Pierre and Marie Curie, IFR des Neurosciences, INSERM U711, Hopital Pitie Salpetriere, Paris, F 75013, France
    Dev Biol 317:246-59. 2008
    ..GCPs have a primary cilium on their surface [Del Cerro, M.P., Snider, R.S. (1972). Studies on the developing cerebellum. II. The ultrastructure of the external granular layer. J Comp Neurol 144, 131-64.]...
  101. ncbi Tonic activation of GABAB receptors reduces release probability at inhibitory connections in the cerebellar glomerulus
    Lisa Mapelli
    Department of Physiological and Pharmacological Sciences and National Consortium for the Physics of Matter, University of Pavia, I 27100 Pavia, Italy
    J Neurophysiol 101:3089-99. 2009
    In the cerebellum, granule cells are inhibited by Golgi cells through GABAergic synapses generating complex responses involving both phasic neurotransmitter release and the establishment of ambient gamma-aminobutyric acid (GABA) levels...

Research Grants105 found, 100 shown here

  1. Principles of Therapy in Cerebellar Disease: Explorations in Ion Channel Mutants
    JOHN SAMUEL STAHL; Fiscal Year: 2013
    ..to offer patients suffering the limb ataxia, imbalance, and visual impairment resulting from diseases of the cerebellum. Such patients are common in the veteran population and becoming more so due to traumatic brain injuries ..
  2. Axonopathy in Glaucoma
    Samuel D Crish; Fiscal Year: 2013
    ..Retinas, optic nerves, the superior colliculus (SC), and cerebellum (as a control structure) will be harvested and immunoblots will be performed to examine the quantity, ..
  3. Imbalances in Calcium Homeostasis: Mechanism Behind Ethanol-Related Dendritic Deg
    Cynthia A Dlugos; Fiscal Year: 2010
    ..Consistent, albeit moderate alcohol consumption in human adults results in permanent alterations in the cerebellum that discretely disrupt motor functions and become more pronounced with age...
  4. Inhibition of matrix proteases to sensitize medulloblastoma cells to radiation
    Andrei L Gartel; Fiscal Year: 2013
    ..PUBLIC HELATH RELEVANCE: Medulloblastomas are one type of brain tumors that are found near the midline of the cerebellum. It is a type of brain tumor that occurs in infants and young children...
  5. Dopamine D1 Receptor in mouse models of primary dystonia
    Laurie J Ozelius; Fiscal Year: 2013
    ..Abundant evidence supports dysfunction of the basal ganglia in dystonia, although other regions, e.g. cerebellum and cortex, are also involved...
  6. Role of G-gamma-7 in striatal cannabinoid and D2 dopamine
    Dana E Selley; Fiscal Year: 2010
    ..b>Cerebellum, which expressed CB1 receptors but does not express Gng7, will serve as negative control region...
  7. Analysis of FIP200 in signal transduction
    Jun Lin Guan; Fiscal Year: 2012
    ..ataxia, which are associated with progressive loss of Purkinje cells, spongiosis and increased apoptosis in the cerebellum. We also found an abnormal accumulation of ubiquitinated protein aggregates, but no decrease in the proteasome ..
    Paul R Schimmel; Fiscal Year: 2012
    ..generated strong upregulation of the unfolded protein response and caused degeneration of Purkinje cells of the cerebellum. Further work showed that editing defects are mutagenic in aging bacteria, because of mistranslation of proteins ..
  9. Oxymax System with Teadmill for Quantifying Exercise in Mice
    Neil B Ruderman; Fiscal Year: 2012
    ..Kandror will examine the mechanism by which exercise increases glucose uptake in the rodent cerebellum in vivo and Drs...
  10. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..g., thalamus, brainstem, and cerebellum)...
  11. Spinocerebellar Ataxia Type 2 Gene and Gene Product
    Stefan M Pulst; Fiscal Year: 2012
    ..Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant disorder leading to degeneration of neurons in the cerebellum and in other cell populations in the CNS...
  12. Rescuing Niemann-Pick C Disease: Pathways of Liver and Brain Degeneration
    Matthew P Scott; Fiscal Year: 2013
    ..hepatomegaly and progressive cognitive and locomotion losses, with massive Purkinje neuron (PN) death in the cerebellum. There is no effective treatment for NPC...
  13. Genetic and Optogenetic Models to Dissect the Role of the Serotonin 1B Receptor
    Katherine M Nautiyal; Fiscal Year: 2013
    ..of serotonergic and non-serotonergic neurons localized broadly in the basal ganglia, hippocampus, thalamus, cerebellum and raphe...
  14. Mechanism Underlying Neurodegeneration Caused by Dysfunction of Pre-mRNA Splicing
    Yichang Jia; Fiscal Year: 2012
    ..only a subset of alternative splicing events, including splicing of small introns, is disrupted in the mutant cerebellum. Therefore, this mutant strain not only provides the definitive evidence to directly link the dysfunction of ..
  15. RAX, PKR and ethanol neurotoxicity
    Gang Chen; Fiscal Year: 2013
    ..Central nervous system (CNS) damage is a major feature observed in FASD patients. The cerebellum is one of the most sensitive areas in the CNS to ethanol toxicity...
  16. Antisense oligonucleotides for the treatment of spinocerebellar ataxia type 2
    Daniel R Scoles; Fiscal Year: 2013
    ..a hereditary neurodegenerative disease affecting cerebellar Purkinje neurons (PNs) and other neurons in the cerebellum, brainstem and cerebrum...
  17. Coordination of orofacial and respiratory movements
    Detlef H Heck; Fiscal Year: 2012
    ..The cerebellum has long been implicated in the coordination of body movements and posture...
  18. Is Maternal Iron Status a Risk Factor in Fetal Alcohol Syndrome?
    Susan M Smith; Fiscal Year: 2010
    ..an established rat model in which early postnatal alcohol exposure disrupts cerebellar neuronal populations and cerebellum-dependent learning...
  19. Translating CNS therapies for the NCLs from rodent models to humans
    Beverly L Davidson; Fiscal Year: 2010
    ..peptide-modified AAVs were redirected from principally targeting hepatocytes, to target also the cerebrum, cerebellum, brain stem and spinal cord. As a result, established neuropathological and behavioral deficits were corrected...
  20. Aging Oxidative Stress and Microglia
    Paula C Bickford; Fiscal Year: 2013
    ..In the current funding period we have demonstrated that inducing inflammation in the cerebellum by infusing TNF1 disrupts cerebellar synaptic plasticity (motor learning) in young rats while blocking TNF1 in ..
  21. Structural consequences of TSC gene mutations in brain
    Peter B Crino; Fiscal Year: 2012
    ..alterations distinct from tubers in post-mortem TSC brain specimens in the cortex, thalamus, basal ganglia, and cerebellum which may contribute to neurocognitive abnormalites in TSC using neuronal and astrocytic protein markers...
  22. Use of Optogenetics to Assess the Role of Climbing Fibers in Motor Learning
    Rhea R Kimpo; Fiscal Year: 2013
    ..The candidate decided to focus on the cerebellum-dependent motor learning in the vestibulo-ocular reflex (VOR) in mice for three reasons: the circuit is ..
  23. The role of the terminal complement pathway in experimental cerebral malaria.
    Theresa N Ramos; Fiscal Year: 2012
    ..manifested by structural and transcriptional changes in Purkinje cells and disruptions in myelination in the cerebellum during ECM...
    Albert R La Spada; Fiscal Year: 2013
    ..The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving the retina and cerebellum, with a phenotype of ataxia and blindness...
  25. Ataxia Telangiectasia in the CNS - Cause and Effect
    Margot Mayer Proschel; Fiscal Year: 2010
    ..The deregulation of the glutamate transporter GLAST seems particular significant as the cerebellum contains a disproportionate ratio of glutaminergic neurons that rely on proper glutamate homeostasis controlled ..
  26. Mechanism of action of novel GluN2C NMDA receptor potentiators
    Alpa Khatri; Fiscal Year: 2013
    ..The GluN1/GluN2C NMDA receptor is highly expressed in the cerebellum, specifically on the cerebellar granule cell at the mossy fiber-cerebellar granule cell synapse...
  27. Genetics and biology of a viable mutant mouse with dystonic movements
    Kathleen J Sweadner; Fiscal Year: 2013
    ..Recent work points to roles for the basal ganglia, thalami, cortex and cerebellum in dystonia, but there are different theories about the underlying mechanisms and pathways...
  28. Investigating readout of cerebellar synchrony in delay eyeblink conditioning
    ALEXANDER D KLOTH; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Neurons in the deep cerebellar nuclei (DCN) form the sole output of the cerebellum and provide the sole readout for Purkinje cells (PC) in the cerebellar cortex that form the basis of many studies in ..
  29. 18F-Mefway PET for Human Aging and Alzheimer's Disease
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..rodent brain imaging studies exhibited selective binding in hippocampus and cortex with limited binding in the cerebellum. PET studies in rhesus monkeys showed 18F-Mefway binding to temporal cortex, hippocampus, raphe and other brain ..
    Richard L Huganir; Fiscal Year: 2013
    ..to elucidate the role of PDZ domain-based receptor complexes in several forms of plasticity in the hippocampus, cerebellum, somatosensory cortex and the amygdala...
  31. Regulation of Forebrain Neurogenesis by the Energy Sensor AMP Kinase
    Biplab Dasgupta; Fiscal Year: 2013
    ..embryo, while in the postnatal brain apoptosis was restricted to the external granule layer of the developing cerebellum. In vitro analysis showed cell-intrinsic G2M-specific defects and apoptosis of [unreadable]1 mutant neural ..
  32. Intrinsic plasticity and information storage in cerebellar Purkinje cells
    CHRISTIAN ROBERT HANSEL; Fiscal Year: 2012
    ..A crucial advantage of the cerebellum in learning research is that the underlying circuitry is simple and well-characterized, which is helpful when ..
  33. Perturbed cell signaling network and suicide neurobiology
    Yogesh Dwivedi; Fiscal Year: 2013
    ..To test our hypothesis, in brain areas implicated in suicidal behavior, i.e., dlPFC and hippocampus (cerebellum as negative control brain region) from well-characterized and well-matched depressed suicide and non-psychiatric ..
    Xiang Yang Chen; Fiscal Year: 2012
    ..the critical CST activity is produced in the hindlimb area of sensorimotor cortex (SMC) and is guided by the cerebellum;and (2) that reflex conditioning can improve locomotion after a spinal cord contusion injury...
  35. Role of Sodium Channel SCN1B in Inherited Epilepsy
    Lori L Isom; Fiscal Year: 2013
    ..6 to the axon initial segment (AIS) in cerebellum. Thus, disruptions in SCN1B expression during development may lead to a spectrum of neurological diseases...
    DANIEL WEBSTER FULTS; Fiscal Year: 2013
    ..Medulloblastomas (MBs) are malignant brain tumors that arise by transformation of neural progenitor cells in the cerebellum in children...
  37. Genome Wide Identification of PTF1-J Targets in Dorsal Neural Tube
    Jane E Johnson; Fiscal Year: 2010
    Ptf1a is required for GABAergic inhibitory neurons in the dorsal spinal cord, cerebellum, and retina...
  38. Effects of octanoic acid for treatment of essential voice tremor
    SOREN YVETTE LOWELL; Fiscal Year: 2013
    ..The origin of the tremor is thought to be within the cerebellum and related pathways of the central nervous system (CNS)1, 2...
  39. Systems Biology for Studies of Cognition in Down Syndrome
    Katheleen Gardiner; Fiscal Year: 2012
    ..48 protein measurements made in nuclear, cytoplasmic and membrane fractions, from hippocampus, cortex and cerebellum, from five DS mouse models. 2...
    Zhude Tu; Fiscal Year: 2012
    ..studies of both radiotracers in monkeys displayed good contrast between the target (striatal) and the reference (cerebellum) region...
  41. Spinocerebellar Ataxia Type 2 Gene and Gene Product
    Stefan M Pulst; Fiscal Year: 2013
    ..transcriptome and neurophysiological changes occurred before any dendritic or cell loss was apparent in the cerebellum. We discovered that mutant ATXN2 induced abnormal calcium release from the ER via enhanced interaction with the ..
  42. Features of chronic tinnitus in an animal model as indicated by MEMRI and MRS
    BORIS M ODINTSOV; Fiscal Year: 2012
    ..has shown that chronic tinnitus is associated with increased activity in the auditory brainstem and the cerebellum. Areas with significantly altered activity were the cochlear nucleus (CN), the inferior colliculus (IC), and the ..
  43. fMRI and Cognition in Adolescent Cannabis Users
    Susan F Tapert; Fiscal Year: 2010
    ..g., frontal lobe, hippocampus, striatum, and cerebellum)...
  44. Neuronal-Specific Splicing of CaV1.2 L-type Calcium Channels
    Kristin Webster; Fiscal Year: 2013
    ..Aim 1 will characterize e1a and e1b expression in specific WT and Nova-2 -/- tissues in the nervous system (cerebellum, cortex, and hippocampus) and cardiac tissue through RT-PCR...
  45. Ethanol and Bcl-2 Gene Interactions in the Developing CNS
    Marieta B Heaton; Fiscal Year: 2012
    ..These relationships are being explored in developing cerebellum, which is highly susceptible to ethanol during the early postnatal period...
    Wendy B Macklin; Fiscal Year: 2013
    ..the consequences of these null mutations for migration of neurons and oligodendrocyte progenitor cells in cerebellum, optic nerve and embryonic telencephalon, using real time imaging...
  47. Role of Inflammation in Progressive Multifocal Leukoencephalopathy
    Igor J Koralnik; Fiscal Year: 2012
    ..and Perfusion Imaging 3) Explore whether JCV-infected neurons in cerebral cortex and granule cell layer of the cerebellum can be recognized by the immune system, determine their prevalence and characterize the molecular determinants ..
  48. Preterm Epo Neuroprotection Trial (PENUT Trial) CCC
    Sandra E Juul; Fiscal Year: 2013
    ..of brain injury;4) whether Epo treatment improves brain structure (volume of gray matter, white matter and cerebellum, brain gyrification, and tract-based spatial statistics) at 36 weeks PMA as measured by MRI...
  49. The toxicity of the RNA CGG repeats in FXTAS
    Lubov T Timchenko; Fiscal Year: 2013
    ..system (UPS) in the FXTAS mouse model, rCGG ki mice, and found accumulation of the Ub-protein conjugates in the cerebellum in these mice...
  50. Requirements for Nfi proteins in Hedgehog signaling and development
    Alexander Brown; Fiscal Year: 2013
    ..Damage to Hh signaling causes birth defects and cancer. In the developing cerebellum Sonic Hedgehog (Shh) secreted from Purkinje neurons modulates the relative activator or repressor function of ..
  51. Rapid and inexpensive screening of disease candidate genes in mice
    KATHLEEN JOYCE MILLEN; Fiscal Year: 2010
    ..a new strategy to rapidly and inexpensively generate mouse models of human structural birth defects of the cerebellum and cerebrum (Dandy-Walker malformation, microcephaly) and severe congenital heart defects (Holt-Oram Syndrome ..
  52. Non-invasive Markers of Neurodegeneration in Movement Disorders
    David E Vaillancourt; Fiscal Year: 2013
    ..Our preliminary data indicate that DTI and fMRI measures from the basal ganglia and cerebellum show excellent promise for differentiating PD, MSA, PSP, and ET, and for tracking longitudinal disease-specific ..
  53. Preterm Epo Neuroprotection Trial (PENUT Trial) DCC
    Patrick J Heagerty; Fiscal Year: 2013
    ..of brain injury;4) whether Epo treatment improves brain structure (volume of gray matter, white matter and cerebellum, brain gyrification, and tract-based spatial statistics) at 36 weeks PMA as measured by MRI...
    David J Linden; Fiscal Year: 2010
    ..In contrast, in the cerebellum it has been possible to propose a 'circuit diagram" for some simple forms of learning such as associative ..
  55. Glutamate Spillover Transmission in the Cerebellar Cortex
    ..It has recently been shown that spillover transmission in the cerebellum mediates communication between excitatory climbing fibers (CFs) and molecular layer interneurons (MLIs), and ..
  56. Regulation of Ptf1a in the Developing Nervous System
    David M Meredith; Fiscal Year: 2010
    ..is essential for specification of GABAergic/inhibitory interneurons in the dorsal spinal cord, retina, and cerebellum. To uncover the molecular mechanisms controlling the generation of inhibitory versus excitatory interneurons, ..
  57. Transcriptional Atlas of Human Brain Development
    PAT R LEVITT; Fiscal Year: 2010
    ..The rest of the time points will add Occipital Cortex (OC), cerebellum (CB) and striatum (STR), for a total of 276 brain samples...
  58. Effect of ethanol on Bergmann glia Ca2+ dynamics during motor behavior
    Martin Paukert; Fiscal Year: 2013
    ..Ethanol is one of the most toxic substances for the cerebellum, acutely leading to ataxic motor behavior...
  59. Mechanisms of Hedgehog Target Gene Selection in Development and Cancer
    Matthew P Scott; Fiscal Year: 2013
    ..During development of the cerebellum, Purkinje neurons emit Sonic hedgehog (Shh), a potent mitogen for adjacent granule neuron precursors (GNPs)...
  60. Functional Imaging of Tremor Circuits and Mechanisms of Treatment Response.
    Fatta B Nahab; Fiscal Year: 2013
    ..with the source of the tremor remaining controversial since all studies show increased activity in the cerebellum (including mimicked tremor in controls), while animal models of ET using harmaline and a single human PET study ..
  61. GABA Receptors and Hilar Neuron Survival in Epilepsy
    Carolyn R Houser; Fiscal Year: 2013
    ..hypothesis that expressing an exogenous GABAAR subunit, which is normally involved in tonic inhibition in the cerebellum, will lead to the formation of functional GABAA receptors and increase tonic inhibition in both groups of hilar ..
  62. Presynaptic Fragile X Proteins
    Michael R Akins; Fiscal Year: 2011
    ..in a subset of circuits, including some implicated in the etiology of autism such as frontal cortex, cerebellum and amygdala. Importantly, FXG expression is developmentally regulated...
  63. Targeting physiologic changes as a route towards therapy for degenerative ataxias
    ..In most inherited degenerative ataxias, selective loss of certain types of neurons occurs primarily in the cerebellum and brain stem despite widespread expression of the disease protein...
  64. Prostaglandins and Cerebellum Development
    Margaret M McCarthy; Fiscal Year: 2013
    ..Pathologies of the cerebellum are frequently associated with both disorders but an effect of inflammation on this brain region has not been ..
  65. In vivo magnetic resonance-based analysis of inherited neurologic disease after g
    HEATHER G EDWARDS; Fiscal Year: 2013
    ..brain, will be measured in each cat at the level of thalamus, frontal cortex, occipital lobe, temporal lobe and cerebellum. High resolution NMR spectroscopy will allow for quantitative analysis of brain metabolites described above and ..
  66. CaMKII, endocannabinoids, synaptic plasticity and motor function
    Roger J Colbran; Fiscal Year: 2013
    ..kinase II (CaMKII) has diverse bidirectional roles controlling excitatory synapses in hippocampus, cortex and cerebellum. While CaMKII is expressed in both striatal MSN subtypes, suggesting that it regulates excitatory inputs to ..
  67. RNA Dysfunction in Selectively Vulnerable Populations in SCA7 Mice
    Gwenn A Garden; Fiscal Year: 2013
    ..However, IO inputs to the cerebellum are both decreased and redistributed in SCA7 mice...
    Zhude Tu; Fiscal Year: 2013
    ..studies of both radiotracers in monkeys displayed good contrast between the target (striatal) and the reference (cerebellum) region...
  69. Rare and Novel Genetic Variation in the Pathogenesis of Cerebellar Ataxia
    BRENT LINDEN FOGEL; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Degeneration of the cerebellum causes ataxia, a disorder of balance and coordination which can be severely disabling and render afflicted individuals unable to walk, speak, or make coordinated ..
  70. Presynaptic Fragile X Proteins
    Michael R Akins; Fiscal Year: 2013
    ..in a subset of circuits, including some implicated in the etiology of autism such as frontal cortex, cerebellum and amygdala. Importantly, FXG expression is developmentally regulated...
  71. Central Autonomic Nervous System Regulation in Heart Failure
    MARY ANN WOO; Fiscal Year: 2013
    ..to determine how damaged brain autonomic nervous system (ANS) regulatory areas (hypothalamus, insula cortex, and cerebellum) respond to an ANS challenge, and to assess the laterality of functional responses to that challenge in heart ..
  72. Genetic and cellular sex differences in cerebellum
    EMILLIE F RISSMAN; Fiscal Year: 2013
    ..This gap is critical and will be addressed by the work in this proposal. The cerebellum is the master coordination center in the brain and its dysregulation produces many kinds of motor diseases...
  73. CRCNS: Cerebellar cortico-nuclear interactions
    Dieter Jaeger; Fiscal Year: 2013
    ..the cerebellar cortex with excitatory input from the rest of the brain to generate the ultimate output of the cerebellum? An interdisciplinary approach of computer modeling and multisite recordings in awake rodents is taken to ..
  74. DTI, MRSI, and Volumetry of Cerebellar Injury in Preterm Neonates
    Anthony James Barkovich; Fiscal Year: 2013
    ..of the cerebral hemispheres, but recent studies have discovered frequent abnormalities of development of the cerebellum, a more posterior part of the brain...
  75. Neuroprotective drugs for A-T
    DAVID WASSARMAN; Fiscal Year: 2013
    ..Neurodegenerative events in the cerebellum that bring about the ataxia begin before the age of two and get worse with age, resulting in wheelchair ..
  76. Allele-Specific RNAi to treat Genetic Prion Disease - Resubmission 01
    James A Mastrianni; Fiscal Year: 2013
    ..mice reproduce all the major features of GSS, including progressive ataxia and PrP amyloid deposits within the cerebellum and hippocampus...
    Gammon M Earhart; Fiscal Year: 2013
    ..We expect treadmill training to enhance activity and connectivity of the primary somatosensory cortex and the cerebellum. We do not expect changes in brain activity or connectivity in the control group. Relevance PD affects 1-1...
  78. Mechanisms Underlying the Cerebellar Contribution to Autism in Mouse Models of Tu
    Peter T Tsai; Fiscal Year: 2013
    ..Cerebellar dysfunction has been implicated in autism pathogenesis;however, the precise role for the cerebellum in these disorders remains unclear...
  79. Neural Activity in Guinea Pig Vestibular Nuclei During Volitional Head Movements
    William M King; Fiscal Year: 2013
    ..We hypothesize that the extra-vestibular signal is encoded in the vestibular nucleus and/or cerebellum from either an efference copy of the intended head movement or proprioceptive feedback related to the head ..
  80. Wnt/planar cell polarity signaling in synapse formation
    Yimin Zou; Fiscal Year: 2013
    ..Wnts have been shown to be able to regulate synapse formation in several embryonic neurons in hippocampus, cerebellum, spinal cord and the neuromuscular junction...
  81. Imaging neonatal Hypoxic Ischemic Injury
    Jiangyang Zhang; Fiscal Year: 2013
    ..In aim 2, we will examine neurodegeneration in the cortex, hippocampus, and cerebellum using oscillating gradient diffusion MRI and histology...
  82. Growth and Development of the Striatum in Huntington's Disease
    Peggy C Nopoulos; Fiscal Year: 2013
    ..report) indicate volume deficits in the striatum with relative sparing or enlargement of the thalamus and cerebellum;and abnormal fractional anisotropy (FA) in multiple tracks...
  83. Plasticity of Voltage Gated Ion Channels in Mammalian Learning and Memory
    Anthony D Morielli; Fiscal Year: 2013
    ..In this research, we will utilize a form of mammalian learning and memory whose neural substrates in the cerebellum are well-understood (eyeblink conditioning) and study a voltage-gated ion channel whose regulation is well-..
  84. Identifying symptomatic and neuroprotective strategies for cerebellar ataxia
    ..At the cellular level, the ataxias are primarily associated with neuronal loss within the cerebellum and its associated pathways...
  85. Cerebello-Basal Ganglia Interactions
    Kamran Khodakhah; Fiscal Year: 2013
    ..An anatomical substrate for a direct disynaptic connection from the cerebellum to the basal ganglia via the centrolateral nucleus of the thalamus has been described both in rodents and ..
  86. Neural mechanisms for smooth pursuit adaptation
    Seiji Ono; Fiscal Year: 2013
    ..Previous studies demonstrate that the macaque cerebellum plays an essential role in adaptive changes of SP...
  87. Evaluation of Cellular Heterogeneity Using Patchclamp and RNA-Seq of Single Cells
    James A Knowles; Fiscal Year: 2013
    ..providing a positive control for differences in the RNA-Seq data;and third, individual Purkinje neurons from the cerebellum, which may have larger inter-cell variation...
  88. Glial control of sensory neuron function
    Shai Shaham; Fiscal Year: 2013
    ..Most excitatory synapses in the cerebellum and hippocampus are glia-ensheated...
  89. Effects of Methylmercury on Neuronal Cell Migration
    Hitoshi Komuro; Fiscal Year: 2010
    ..examination revealed widespread neuronal degeneration, abnormal arrangement of neurons in the cerebrum and cerebellum, and diffuse white matter gliosis in the brain of victims...
  90. Cerebellar dysfunction in schizophrenia
    William P Hetrick; Fiscal Year: 2013
    ..schizophrenia (SZ) is associated with learning and temporal processing deficits linked to dysfunction of the cerebellum (CB) and related circuits...
  91. Molecular Analysis of BDNF-TrkB Regulation of Synapse Formation and Maintenance
    Louis French Reichardt; Fiscal Year: 2013
    ..We will characterize mechanisms through which TrkB regulates inhibitory synapse formation and maintenance in the cerebellum with the expectation that the insights obtained will prove important for understanding the role of TrkB in many ..
  92. DNA methylation in Alzheimer?s disease and normally aged brain
    Paul D Coleman; Fiscal Year: 2013
    ..DNA methylation sites in a genome wide study of an affected (temporal neocortex) and a minimally affected (cerebellum) brain region of Alzheimer's disease (AD) and non demented control cases...
  93. A model system to study the interaction of multiple processes for motor learning
    Jordan A Taylor; Fiscal Year: 2013
    ..of these processes will be explored by testing neurological populations with degenerative disorders of the cerebellum or basal ganglia, and patients with cortical lesions affecting prefrontal regions...
  94. Role of Hox4 paralogs in the development of precerebellar neuronal function
    CHARLOTTE LOUISE GROVE; Fiscal Year: 2013
    ..Based on work in the adult goldfish, Area II neurons code for eye velocity and provide input to the cerebellum via mossy fibers, while the IO neurons give rise to the climbing fibers and signal retinal-slip velocity...
  95. Congenital brain malformations caused by aberrant head mesenchymal signaling
    KATHLEEN JOYCE MILLEN; Fiscal Year: 2013
    ..pathogenesis and causative genes for Dandy-Walker malformation, the most common structural malformation of the cerebellum. Dandy-Walker malformation is common, affecting 1/3000 live births and causes significant motor and intellectual ..
  96. Transcranial Stimulation in Spino-Cerebellar Ataxia
    Alvaro Pascual-Leone; Fiscal Year: 2013
    ..for many of the SCA subtypes are known, and even though we know that they all are associated with damage of the cerebellum and other specific parts of the brain, there is no cure for SCA and we still lack an effective symptomatic ..
    ..2) thyroid hormone (TH) is critical for normal CNS development; and (3) motor coordination, controlled by the cerebellum, is affected in both astronauts and animals under altered gravity...
    Andrej Rotter; Fiscal Year: 1992
    ..is to study the expression gamma-aminobutyric acid/benzodiazepine (GABA/BZ) receptors in bovine and murine cerebellum during development...
    JEREMY SCHMAHMANN; Fiscal Year: 1999
    ..National Library of Medicine is to provide short term assistance for the preparation of an atlas of the human cerebellum in printed book form and on CD-ROM...
  100. 18F-Mefway for Imaging Mood Disorders and Alzheimer's Disease
    JOGESH MUKHERJEE; Fiscal Year: 2009
    ..selective binding of F-mefway in hippocampus, cortex and other brain regions, 18 with limited binding in the cerebellum. Preliminary in vitro studies showed serotonin displaced 18 F-mefway from various brain regions with IC50 in the ..
    Richard Maas; Fiscal Year: 2001
    ..in abnormal development of the central nervous system, typified by poor neurite growth and synaptogenesis in the cerebellum. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), members of the neurotrophic factor family, ..