vestibular nuclei

Summary

Summary: The four cellular masses in the floor of the fourth ventricle giving rise to a widely dispersed special sensory system. Included is the superior, medial, inferior, and LATERAL VESTIBULAR NUCLEUS. (From Dorland, 27th ed)

Top Publications

  1. pmc Bidirectional control of BK channel open probability by CAMKII and PKC in medial vestibular nucleus neurons
    Ingrid van Welie
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, USA
    J Neurophysiol 105:1651-9. 2011
  2. ncbi Zonal organization of the mouse flocculus: physiology, input, and output
    Martijn Schonewille
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    J Comp Neurol 497:670-82. 2006
  3. pmc Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents
    Aryn H Gittis
    Salk Institute for Biological Studies, Howard Hughes Medical Institute, Systems Neurobiology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurophysiol 104:1625-34. 2010
  4. ncbi Vestibular nuclei and cerebellum put visual gravitational motion in context
    William L Miller
    Dept of Neuromotor Physiology, Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
    J Neurophysiol 99:1969-82. 2008
  5. ncbi Vestibular signals in primate thalamus: properties and origins
    Hui Meng
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:13590-602. 2007
  6. ncbi Long-lasting increases in intrinsic excitability triggered by inhibition
    Alexandra B Nelson
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 40:609-20. 2003
  7. pmc Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning
    Peer Wulff
    Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK
    Nat Neurosci 12:1042-9. 2009
  8. ncbi Probing the human vestibular system with galvanic stimulation
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute, Easy St, Randwick, Sydney, NSW 2031, Australia
    J Appl Physiol (1985) 96:2301-16. 2004
  9. ncbi Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei
    Julien Puyal
    Department of Cell Biology and Morphology, University of Lausanne, 1005 Lausanne, Switzerland
    J Comp Neurol 497:610-21. 2006
  10. ncbi Signal processing in the vestibular system during active versus passive head movements
    Kathleen E Cullen
    Aerospace Medical Research Unit, Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 91:1919-33. 2004

Detail Information

Publications233 found, 100 shown here

  1. pmc Bidirectional control of BK channel open probability by CAMKII and PKC in medial vestibular nucleus neurons
    Ingrid van Welie
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, San Diego, CA 92037, USA
    J Neurophysiol 105:1651-9. 2011
    ....
  2. ncbi Zonal organization of the mouse flocculus: physiology, input, and output
    Martijn Schonewille
    Department of Neuroscience, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    J Comp Neurol 497:670-82. 2006
    ..The present study illustrates that Purkinje cells in the murine flocculus are organized in discrete zones with specific functions, specific input - output relations, and a specific histochemical signature...
  3. pmc Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents
    Aryn H Gittis
    Salk Institute for Biological Studies, Howard Hughes Medical Institute, Systems Neurobiology Laboratory, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Neurophysiol 104:1625-34. 2010
    ..These results demonstrate how divergent firing properties of two neuronal populations arise through the interplay of at least three ionic currents...
  4. ncbi Vestibular nuclei and cerebellum put visual gravitational motion in context
    William L Miller
    Dept of Neuromotor Physiology, Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
    J Neurophysiol 99:1969-82. 2008
    ..correlates of these visual context effects on gravitational motion processing in the vestibular nuclei and posterior cerebellar vermis...
  5. ncbi Vestibular signals in primate thalamus: properties and origins
    Hui Meng
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:13590-602. 2007
    ..regions of the ventral posterior and ventral lateral nuclei, and so were not restricted to the known vestibular nuclei projection zones...
  6. ncbi Long-lasting increases in intrinsic excitability triggered by inhibition
    Alexandra B Nelson
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Neuron 40:609-20. 2003
    ..Firing rate potentiation is a novel form of cellular plasticity that could contribute to motor learning in the vestibulo-ocular reflex...
  7. pmc Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning
    Peer Wulff
    Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen, UK
    Nat Neurosci 12:1042-9. 2009
    ..basis of modeling our experimental data, we propose that feedforward inhibition, by controlling the fine-scale patterns of Purkinje cell activity, enables the induction of plasticity in neurons of the cerebellar and vestibular nuclei.
  8. ncbi Probing the human vestibular system with galvanic stimulation
    Richard C Fitzpatrick
    Prince of Wales Medical Research Institute, Easy St, Randwick, Sydney, NSW 2031, Australia
    J Appl Physiol (1985) 96:2301-16. 2004
    ..To achieve this, neurons in the vestibular nuclei receive convergent signals from all vestibular receptors and somatosensory and cortical inputs...
  9. ncbi Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei
    Julien Puyal
    Department of Cell Biology and Morphology, University of Lausanne, 1005 Lausanne, Switzerland
    J Comp Neurol 497:610-21. 2006
    The patterns of development of the vestibular nuclei (VN) and their main connections involving glutamate neurotransmission offer a good model for studying the function of the glial-derived neuromodulator D-serine in synaptic plasticity...
  10. ncbi Signal processing in the vestibular system during active versus passive head movements
    Kathleen E Cullen
    Aerospace Medical Research Unit, Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 91:1919-33. 2004
    ..review first considers how head-in-space velocity is processed at the level of the vestibular afferents and vestibular nuclei during active versus passive head movements...
  11. pmc Neuronal classification and marker gene identification via single-cell expression profiling of brainstem vestibular neurons subserving cerebellar learning
    Takashi Kodama
    Howard Hughes Medical Institute, Salk Institute for Biological Studies, La Jolla, California, 92037, USA
    J Neurosci 32:7819-31. 2012
    ..This strategy is applicable throughout the nervous system and could facilitate the use of molecular genetic tools to examine the behavioral roles of distinct neuronal populations...
  12. ncbi Differential projections from the vestibular nuclei to the flocculus and uvula-nodulus in pigeons (Columba livia)
    Janelle M P Pakan
    Centre for Neuroscience, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    J Comp Neurol 508:402-17. 2008
    ..In summary, there were clear differences with respect to the projections from the vestibular nuclei to functionally distinct parts of the vestibulocerebellum...
  13. ncbi Post-lesional plasticity in the central nervous system of the guinea-pig: a "top-down" adaptation process?
    N Vibert
    Laboratoire de Neurobiologie des Reseaux Sensorimoteurs, CNRS ESA 7060, Universite Paris 5, Centre Universitaire des Saints Peres, France
    Neuroscience 94:1-5. 1999
    ..Similar strategies may be used by the mammalian brain to compensate for other types of deafferentations or environmental changes...
  14. ncbi Long-term potentiation in the rat medial vestibular nuclei depends on locally synthesized 17beta-estradiol
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, I 06126 Perugia, Italy
    J Neurosci 29:10779-83. 2009
    ..We suggest that the synthesis of E(2) occurs after aromatase activation during HFS and facilitates the development of vestibular synaptic plasticity by influencing glutamate and GABA transmission...
  15. ncbi Neurosteroid modulation of neuronal excitability and synaptic transmission in the rat medial vestibular nuclei
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Via del Giochetto, I 06126 Perugia, Italy
    Eur J Neurosci 26:23-32. 2007
    ..vestibular neurons, by analysing their effects on the amplitude of the field potentials evoked in the medial vestibular nuclei (MVN) by vestibular afferent stimulation and on the spontaneous firing rate of MVN neurons...
  16. ncbi New neurons in the vestibular nuclei complex after unilateral vestibular neurectomy in the adult cat
    Brahim Tighilet
    UMR 6149 Neurobiologie Intégrative et Adaptative Pôle 3C, Comportement, Cerveau, Cognition, Centre de St Charles, Case B, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    Eur J Neurosci 25:47-58. 2007
    ..neurectomy (UVN), we previously reported gamma-aminobutyric acid (GABA)ergic neurons are upregulated in the vestibular nuclei (VN) in the adult cat...
  17. ncbi Otolith fibers and terminals in chick vestibular nuclei
    Anastas Popratiloff
    Department of Anatomy and Cell Biology, George Washington University Medical Center, Washington, DC 20037, USA
    J Comp Neurol 502:19-37. 2007
    The distribution of gravity-sensing, otolith afferent fibers and terminals was studied in the vestibular nuclei of 4-5-day hatchling chicks by using single and double labeling of fibers and terminals with biocytin conjugated to Alexa ..
  18. ncbi Selective processing of vestibular reafference during self-generated head motion
    J E Roy
    Aerospace Medical Research Unit, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 21:2131-42. 2001
    The vestibular sensory apparatus and associated vestibular nuclei are generally thought to encode head-in-space motion...
  19. ncbi Rebalancing the commissural system: mechanisms of vestibular compensation
    Bayanne Olabi
    Centre for Integrative Physiology, University of Edinburgh College of Medicine and Veterinary Medicine, Edinburgh, UK
    J Vestib Res 19:201-7. 2009
    ..evidence strongly implicates the vestibular commissural inhibitory system which links the brainstem vestibular nuclei of the two sides, both in causing the initial severe oculomotor and postural symptoms of vestibular ..
  20. pmc Multimodal integration in rostral fastigial nucleus provides an estimate of body movement
    Jessica X Brooks
    Aerospace Medical Research Unit, Department of Physiology, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Neurosci 29:10499-511. 2009
    ..space, whereas the other half encoded the motion of the head in space in a manner similar to neurons in the vestibular nuclei. Notably, neurons encoding body motion responded to both vestibular and proprioceptive stimulation (..
  21. ncbi Projections from the parabrachial nucleus to the vestibular nuclei: potential substrates for autonomic and limbic influences on vestibular responses
    Carey D Balaban
    Departments of Otolaryngology and Neurobiology, Eye and Ear Institute, University of Pittsburgh, 203 Lothrop Street, Pittsburgh, PA 15213, USA
    Brain Res 996:126-37. 2004
    ..amine, Phaseolus vulgaris leucoagglutinin, Fluoro-Gold or tetramethylrhodamine dextran amine into either the vestibular nuclei or the PBN and KF nuclei. The results were similar in both rats and rabbits...
  22. ncbi Activity of vestibular nuclei neurons during vestibular and optokinetic stimulation in the alert mouse
    M Beraneck
    Department of Physiology, McGill University, Montreal, Quebec, Canada
    J Neurophysiol 98:1549-65. 2007
    ..Here we characterized the responses of individual neurons in the mouse vestibular nuclei during vestibular (horizontal whole body rotations) and full field visual stimulation...
  23. ncbi Intrinsic excitability changes in vestibular nucleus neurons after unilateral deafferentation
    A Him
    Department of Biomedical Sciences (Physiology, Edinburgh University Medical School, Teviot Place, EH8 9AG, Edinburgh, UK
    Brain Res 908:58-66. 2001
    ..These results therefore provide further evidence for synaptic and neuronal plasticity in ipsi-lesional MVN neurons during vestibular compensation...
  24. ncbi Resonance of spike discharge modulation in neurons of the guinea pig medial vestibular nucleus
    L Ris
    Laboratory of Neurosciences, University of Mons-Hainaut, B-7000 Mons, Belgium
    J Neurophysiol 86:703-16. 2001
    ..However, the more sensitive and phasic type B neurons contribute to both low- and high-frequency control as well as signal detection and would amplify the contribution of both irregular and regular primary afferents at high frequencies...
  25. ncbi Opposite long-term synaptic effects of 17β-estradiol and 5α-dihydrotestosterone and localization of their receptors in the medial vestibular nucleus of rats
    Silvarosa Grassi
    Dipartimento di Medicina Interna, Sezione di Fisiologia Umana, Universita di Perugia, Via del Giochetto, I 06126 Perugia, Italy
    Brain Res Bull 97:1-7. 2013
    ....
  26. ncbi Mitochondrial ultrastructure and apoptotic protein expression in the vestibular nucleus complex following unilateral labyrinthectomy
    John C Ashton
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, University of Otago, Dunedin, New Zealand
    Brain Res 1055:165-70. 2005
    ..However, we did detect a small but statistically significant upregulation of the anti-apoptotic protein Bcl-2 in the contralateral VNC at 10 h post-UL...
  27. ncbi Detection of herpes simplex virus type 1 in human vestibular nuclei
    V Arbusow
    Department of Neurology, Klinikum Grobetahadern, University of Munich, Munich, Germany
    Neurology 55:880-2. 2000
    The distribution of herpes simplex virus type 1 (HSV-1) in human geniculate, vestibular ganglia, and vestibular nuclei was determined in 10 human temporal bones and brainstems of five individuals by PCR...
  28. ncbi The anatomy of the vestibular nuclei
    Stephen M Highstein
    Washington University School of Medicine, Box 8115, 4566 Scott Avenue, St Louis, MO 63110, USA
    Prog Brain Res 151:157-203. 2006
    ..The termination sites of these eighth nerve afferents define the territory of the vestibular nuclei in the brainstem. (There is also a subset of afferents that project directly to the cerebellum...
  29. ncbi Long-term potentiation of synaptic response and intrinsic excitability in neurons of the rat medial vestibular nuclei
    V E Pettorossi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Via del Giochetto, I 06126 Perugia, Italy
    Neuroscience 187:1-14. 2011
    ....
  30. ncbi Comparative aspects of the hodological organization of the vestibular nuclear complex and related neuron populations
    Carmen Diaz
    Faculty of Medicine, Castilla La Mancha University, Albacete Campus, Albacete, Spain
    Brain Res Bull 57:307-12. 2002
    ..Here, we compare and contrast hodological patterns in birds and other vertebrate classes in an attempt to elucidate common denominators that may represent an evolutionary bauplan for vestibular connectivity...
  31. ncbi Aging and the human vestibular nuclei: morphometric analysis
    J C Alvarez
    , , Universidad de Oviedo, , Oviedo, Spain
    Mech Ageing Dev 114:149-72. 2000
    ..The study of the effects of aging in the vestibular nuclei could have clinical interest due to the high prevalence of balance control and gait problems in the elderly...
  32. ncbi Long-term potentiation and depression after unilateral labyrinthectomy in the medial vestibular nucleus of rats
    Vito Enrico Pettorossi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Perugia, Italy
    Acta Otolaryngol 123:182-6. 2003
    ..These changes in synaptic plasticity may be useful for re-balancing the tonic discharge of the MVN of the two sides during vestibular compensation, and for enhancing the dynamic responses of the deafferented MVN neurons in the long term...
  33. ncbi Current concepts of vestibular nucleus function: transformation of vestibular signals in the vestibular nuclei
    R McCrea
    Department of Neurobiology, Pharmacology and Physiology, University of Chicago, Illinois 60637, USA
    Ann N Y Acad Sci 942:328-44. 2001
    ..stage of sensory processing in the brain, and in many cases are apparent in the responses of neurons in the vestibular nuclei that receive direct inputs from the vestibular nerve...
  34. pmc Role of the flocculus in mediating vestibular nucleus neuron plasticity during vestibular compensation in the rat
    Alex R Johnston
    Department of Biomedical Sciences Physiology, Edinburgh University Medical School, Hugh Robson Building, George Square, Edinburgh EH8 9XD, Scotland, UK
    J Physiol 545:903-11. 2002
    ..These observations ascribe functional significance to the high levels of GR and 11-beta-HSD Type 1 expression in cerebellum...
  35. ncbi Quantitative changes in gene expression of glutamate receptor subunits/subtypes in the vestibular nucleus, inferior olive and flocculus before and following unilateral labyrinthectomy in the rat: real-time quantitative PCR method
    A Horii
    Department of Pharmacology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    Exp Brain Res 139:188-200. 2001
    ..It is suggested that such changes in the activities of the floccular-VNC pathways may be important to the vestibular compensation process...
  36. ncbi Cyclic estrogenic fluctuation influences synaptic transmission of the medial vestibular nuclei in female rats
    Vito E Pettorossi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Italy
    Acta Otolaryngol 131:434-9. 2011
    ..The estrous cycle in female rats influences the basal synaptic responsiveness and plasticity of the medial vestibular nucleus (MVN) neurons through different levels of circulating 17β-estradiol (cE(2))...
  37. ncbi Firing properties of GABAergic versus non-GABAergic vestibular nucleus neurons conferred by a differential balance of potassium currents
    Aryn H Gittis
    University of California, San Diego Graduate Program in Neuroscience, The Salk Institute for Biological Studies, Howard Hughes Medical Institute, La Jolla, California 92037, USA
    J Neurophysiol 97:3986-96. 2007
    ..GABAergic and non-GABAergic neurons in the medial vestibular nuclei, identified in GIN and YFP-16 lines of transgenic mice, respectively, exhibit different firing properties in ..
  38. ncbi Influence of sex and estrous cycle on synaptic responses of the medial vestibular nuclei in rats: role of circulating 17β-estradiol
    Silvarosa Grassi
    Dipartimento di Medicina Interna, Sezione di Fisiologia Umana, Universita di Perugia, Via del Giochetto, I 06126 Perugia, Italy
    Brain Res Bull 87:319-27. 2012
    ....
  39. ncbi Synaptic plasticity in the medial vestibular nuclei: role of glutamate receptors and retrograde messengers in rat brainstem slices
    S Grassi
    Dipartimento di Medicina Interna, Sezione di Fisiologia Umana, Universita di Perugia, I 06100, Perugia, Italy
    Prog Neurobiol 64:527-53. 2001
    The analysis of cellular-molecular events mediating synaptic plasticity within vestibular nuclei is an attempt to explain the mechanisms underlying vestibular plasticity phenomena...
  40. pmc Effects of visceral inputs on the processing of labyrinthine signals by the inferior and caudal medial vestibular nuclei: ramifications for the production of motion sickness
    Milad S Arshian
    Department of Otolaryngology, Eye and Ear Institute, University of Pittsburgh, Room 519, Pittsburgh, PA 15213, USA
    Exp Brain Res 228:353-63. 2013
    ..Consequently, it has been hypothesized that neurons in the caudal vestibular nuclei participate in triggering motion sickness and that visceral inputs to the vestibular nucleus complex can ..
  41. ncbi Effects of 17beta-estradiol on synaptic plasticity in the rat medial vestibular nuclei
    Silvarosa Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Perugia, Italy
    Acta Otolaryngol 129:390-4. 2009
    This study shows that 17beta-estradiol (E(2)) can amplify the long-term potentiation (LTP) induced in the vestibular nuclei by high frequency stimulation (HFS), while potentiation induced by E(2) alone, which is unrelated to synaptic ..
  42. ncbi Efferent connections of the vestibular nuclei in the rat: a neuromorphological study using PHA-L
    Clara Matesz
    Department of Anatomy, Histology and Embryology, University of Debrecen, Medical and Health Science Center, Debrecen, Hungary
    Brain Res Bull 57:313-5. 2002
    The efferent connections of the superior, medial, lateral, and descending vestibular nuclei were studied with anterograde tracing methods in rats...
  43. ncbi Dynamics of glutamatergic synapses in the medial vestibular nucleus of the mouse
    Dianne M Broussard
    Division of Fundamental Neurobiology, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada
    Eur J Neurosci 29:502-17. 2009
    ....
  44. ncbi Distribution of zebrin-immunoreactive Purkinje cell terminals in the cerebellar and vestibular nuclei of birds
    Douglas R Wylie
    University Centre for Neuroscience, Department of Psychology, University of Alberta, Edmonton, Alberta, T6G 2E9 Canada
    J Comp Neurol 520:1532-46. 2012
    ..We discuss our findings in light of similar studies in rats and with respect to the corticonuclear projections to the cerebellar nuclei and the functional connections of the vestibulocerebellum with the vestibular nuclei.
  45. pmc Intrinsic physiology of identified neurons in the prepositus hypoglossi and medial vestibular nuclei
    Kristine E Kolkman
    Neurosciences Graduate Program, University of California San Diego, San Diego, CA, USA
    J Vestib Res 21:33-47. 2011
    ..These results indicate that intrinsic membrane properties are differentially tuned in MVN and NPH neurons subserving different functions...
  46. pmc Direction discrimination thresholds of vestibular and cerebellar nuclei neurons
    Sheng Liu
    Department of Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:439-48. 2010
    ..Such a characterization of neural sensitivity is critical for understanding how early stages of vestibular processing limit behavioral performance...
  47. ncbi Organization of projections from the raphe nuclei to the vestibular nuclei in rats
    A L Halberstadt
    Department of Neurobiology, Biological Sciences Tower, 203 Lothrop Street, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 120:573-94. 2003
    Previous anatomic and electrophysiological evidence suggests that serotonin modulates processing in the vestibular nuclei. This study examined the organization of projections from serotonergic raphe nuclei to the vestibular nuclei in ..
  48. ncbi Spontaneous activity in rat vestibular nuclei in brain slices and effects of acetylcholine agonists and antagonists
    Yizhe Sun
    Department of Otolaryngology, Head and Neck Surgery, Medical College of Ohio, 3065 Arlington Avenue, Toledo, OH 43614, USA
    Brain Res 934:58-68. 2002
    ....
  49. ncbi An in situ hybridization and immunofluorescence study of GABA(A) and GABA(B) receptors in the vestibular nuclei of the intact and unilaterally labyrinthectomized rat
    Lyndell Eleore
    LNRS, CNRS Paris 5, Centre Universitaire des Saints Peres, 45 Rue des Saints Peres, 75270, Paris Cedex 06, France
    Exp Brain Res 160:166-79. 2005
    ..of the GABA(A) receptors and of the different variants of GABA Breceptors are modulated in rat medial vestibular nuclei (MVN) following unilateral labyrinthectomy...
  50. ncbi The coding of head orientations in neurons of bilateral vestibular nuclei of cats after unilateral labyrinthectomy: response to off-vertical axis rotation
    Y S Chan
    Department of Physiology, Faculty of Medicine, The University of Hong Kong
    Exp Brain Res 114:293-303. 1997
    ..These suggest that there is a segregation of otolithic signals to reach the ipsilateral and contralateral vestibular nuclei. Taken together, the present study demonstrates that one-dimensional and two-dimensional neuronal responses ..
  51. ncbi Connections between the vestibular nuclei and brain stem regions that mediate autonomic function in the rat
    J D Porter
    University of Pittsburgh, Department of Otolaryngology, PA 15213, USA
    J Vestib Res 7:63-76. 1997
    ..These findings are consistent with the hypothesis that a common pattern of vestibular nuclear projections to autonomic regions is shared by rabbits, cats, and rats...
  52. pmc Projections from the vestibular nuclei and nucleus prepositus hypoglossi to dorsal raphe nucleus in rats
    Bruna Cuccurazzu
    Department of Otolaryngology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neurosci Lett 439:70-4. 2008
    ..Recent studies using anterograde and retrograde tracers have shown that vestibular nuclei are targeted by regionally selective projections from the serotonergic dorsal raphe nucleus...
  53. ncbi Immediate early gene expression in the vestibular nuclei and related vegetative areas in rats during space flight
    O Pompeiano
    Dipartimento di Fisiologia e Biochimica, Scuola Medica, Universita di Pisa, Pisa, Italy
    Acta Otolaryngol Suppl 545:120-6. 2001
    ..respect to control rats, the number of labeled cells increased in flight animals in the medial and spinal vestibular nuclei (but not in the lateral vestibular nucleus) at FD2, decreased at FD14, greatly increased at R + 1 and ..
  54. pmc Direct projections from the caudal vestibular nuclei to the ventrolateral medulla in the rat
    G R Holstein
    Department of Neurology, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuroscience 175:104-17. 2011
    ..Since a direct pathway from the vestibular nuclei to the rostral ventrolateral medulla would provide a morphological substrate for rapid modifications in ..
  55. ncbi Retrograde neuron tracing with microspheres reveals projection of CGRP-immunolabeled vestibular afferent neurons to the vestibular efferent nucleus in the brainstem of rats
    Fang Lu Chi
    Department of Otology and Skull Base Surgery, Eye and ENT Hospital, Fudan University, Shanghai, PR China
    Neuroendocrinology 85:131-8. 2007
    ....
  56. ncbi Projections from the vestibular nuclei to the hypothalamic paraventricular nucleus: morphological evidence for the existence of a vestibular stress pathway in the rat brain
    Balazs Markia
    Neuromorphological and Neuroendocrine Research Laboratory, Department of Anatomy, Semmelweis University and the Hungarian Academy of Sciences, Tüzoltó utca 58, 1094, Budapest, Hungary
    Brain Struct Funct 213:239-45. 2008
    ..of cholera toxin B subunit, a monosynaptic retrograde tracer into the PVN failed to label any cells in the vestibular nuclei. These results provide anatomical evidence for the existence of a vestibulo-paraventricular polysynaptic ..
  57. ncbi Molecular mechanisms of vestibular compensation in the central vestibular system--review
    T Kitahara
    Department of Otolaryngology, Osaka University Medical School, Japan
    Acta Otolaryngol Suppl 539:19-27. 1998
    ....
  58. ncbi Dissociating self-generated from passively applied head motion: neural mechanisms in the vestibular nuclei
    Jefferson E Roy
    Aerospace Medical Research Unit, Department of Physiology, McGill University, Montreal, Quebec, Canada H3G 1Y6
    J Neurosci 24:2102-11. 2004
    ..We found that a cancellation signal was gated into the vestibular nuclei only in conditions in which the activation of neck proprioceptors matched that expected on the basis of the ..
  59. pmc Response linearity of alert monkey non-eye movement vestibular nucleus neurons during sinusoidal yaw rotation
    Shawn D Newlands
    University of Texas Medical Branch, Department of Otolaryngology, Galveston, TX, USA
    J Neurophysiol 102:1388-97. 2009
    ..the response sensitivity and linearity of non-eye movement central vestibular neurons, we recorded from the vestibular nuclei in awake rhesus macaques during sinusoidal yaw rotation at frequencies between 0.1 and 2 Hz and between 7...
  60. ncbi Differential spatial organization of otolith signals in frog vestibular nuclei
    Hans Straka
    Physiologisches Institut, 80336 Munchen, Germany
    J Neurophysiol 90:3501-12. 2003
    ..saccular nerve branches in the isolated frog hindbrain were recorded within a stereotactic outline of the vestibular nuclei. Utricular and lagenar nerve-evoked activation maps overlapped strongly in the lateral and descending ..
  61. pmc In vivo conditions induce faithful encoding of stimuli by reducing nonlinear synchronization in vestibular sensory neurons
    Adam D Schneider
    Department of Physics, McGill University, Montreal, Quebec, Canada
    PLoS Comput Biol 7:e1002120. 2011
    Previous studies have shown that neurons within the vestibular nuclei (VN) can faithfully encode the time course of sensory input through changes in firing rate in vivo...
  62. ncbi Dye coupling in developing vestibular nuclei
    M Shao
    Department of Anatomy and Regenerative Biology, George Washington University Medical Center, Washington, DC 20037, USA
    J Neurosci Res 86:832-44. 2008
    ..Thus, transient neuron-neuron and neuron-glia coupling may both play roles in establishing excitability in vestibular nucleus neurons during development...
  63. ncbi Cortical influences on the vestibular nuclei of the cat
    V J Wilson
    The Rockefeller University, New York, NY 10021, USA
    Exp Brain Res 125:1-13. 1999
    ..We conclude that, by their influence on vestibulospinal neurons, neurons in cortical areas 2 and 3a should be able to modulate, in behaving animals, vestibular reflexes acting on the neck and limbs...
  64. ncbi Intrinsic firing dynamics of vestibular nucleus neurons
    Chris Sekirnjak
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    J Neurosci 22:2083-95. 2002
    ..We conclude that the heterogeneity of firing dynamics observed in response to head movements in intact animals reflects intrinsic as well as circuit properties...
  65. ncbi Polysynaptic pathways from the vestibular nuclei to the lateral mammillary nucleus of the rat: substrates for vestibular input to head direction cells
    J E Brown
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Exp Brain Res 161:47-61. 2005
    ..The present study tested the hypothesis that a polysynaptic pathway connects the vestibular nuclei with the LMN via one or more relay nuclei...
  66. ncbi Effects of chronic infusion of a GABAA receptor agonist or antagonist into the vestibular nuclear complex on vestibular compensation in the guinea pig
    Catherine M Gliddon
    Vestibular Research Group, Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Dunedin, New Zealand
    J Pharmacol Exp Ther 313:1126-35. 2005
    ..Furthermore, the neurochemical mechanism responsible for vestibular compensation can cope with the both the GABA(A) receptor-mediated and the UVD-induced decrease in resting activity...
  67. ncbi Afferent pathways to the region of the vestibular nuclei that participates in cardiovascular and respiratory control
    B J Jian
    Department of Otolaryngology, University of Pittsburgh, Eye and Ear Institute, Room 519, 203 Lothrop Street, Pittsburgh, PA 15213, USA
    Brain Res 1044:241-50. 2005
    Prior experiments have shown that a region of the medial and inferior vestibular nuclei contributes to cardiovascular and respiratory regulation...
  68. ncbi Dynamics of vestibular neurons during rotational motion in alert rhesus monkeys
    J David Dickman
    Department of Otolaryngology, Washington University, 660 S Euclid, St Louis, MO 63110, USA
    Exp Brain Res 155:91-101. 2004
    The temporal processing in the encoding of head rotation was investigated by comparing the dynamics of vestibular nuclei neurons with those of the regularly and irregularly firing semicircular canal afferents in alert rhesus monkeys...
  69. ncbi Cell proliferation and survival in the vestibular nucleus following bilateral vestibular deafferentation in the adult rat
    Yiwen Zheng
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago Medical School, Frederick St, Dunedin, New Zealand
    Neurosci Lett 468:85-8. 2010
    ..These results raise questions about the potential functional significance of cell proliferation in the VNC following vestibular lesions...
  70. pmc Multimodal integration after unilateral labyrinthine lesion: single vestibular nuclei neuron responses and implications for postural compensation
    Soroush G Sadeghi
    McGill University, Department of Physiology, 3655 Sir William Osler, Montreal, Quebec H3G 1Y6, Canada
    J Neurophysiol 105:661-73. 2011
    ..Here, we studied another class of neurons, i.e., the vestibular-only neurons, in the vestibular nuclei that mediate vestibulospinal reflexes and provide information for higher brain areas...
  71. ncbi Memory trace of motor learning shifts transsynaptically from cerebellar cortex to nuclei for consolidation
    F Shutoh
    Laboratory for Motor Learning Control, RIKEN Brain Science Institute, Hirosawa 2 1, Wako, Saitama 351 0198, Japan
    Neuroscience 139:767-77. 2006
    ..that the memory is formed within the cerebellar flocculus, and the other that the memory is formed within vestibular nuclei. Here we developed a new paradigm of long-term adaptation of mouse horizontal optokinetic response eye ..
  72. ncbi GABAergic systems in the vestibular nucleus and their contribution to vestibular compensation
    Catherine M Gliddon
    Department of Pharmacology and Toxicology, School of Medical Sciences, University of Otago, Dunedin, New Zealand
    Prog Neurobiol 75:53-81. 2005
    ....
  73. ncbi Decreases in CaMKII activity trigger persistent potentiation of intrinsic excitability in spontaneously firing vestibular nucleus neurons
    Alexandra B Nelson
    Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA
    Neuron 46:623-31. 2005
    ..Reductions in CaMKII activity are necessary and sufficient to induce firing rate potentiation and may contribute to motor learning in the vestibulo-ocular reflex...
  74. ncbi Intrinsic membrane properties of vertebrate vestibular neurons: function, development and plasticity
    H Straka
    L N R S, CNRS UMR 7060 Université René Descartes Paris 5, Paris, France
    Prog Neurobiol 76:349-92. 2005
    ....
  75. pmc Information transmission and detection thresholds in the vestibular nuclei: single neurons vs. population encoding
    Corentin Massot
    Department of Physiology, Aerospace Medical Research Unit, McGill University, Montreal, Quebec, Canada
    J Neurophysiol 105:1798-814. 2011
    ..We studied how central neurons within the vestibular nuclei integrate information from both afferent classes by recording from a group of neurons termed vestibular only ..
  76. pmc Neurogenic potential of the vestibular nuclei and behavioural recovery time course in the adult cat are governed by the nature of the vestibular damage
    Sophie Dutheil
    Departement de Neurosciences, UMR 6149 Neurosciences Intégratives et Adaptatives, Université de Provence CNRS Pôle 3C Comportement, Cerveau, Cognition, Centre de Saint Charles, Marseille, France
    PLoS ONE 6:e22262. 2011
    Functional and reactive neurogenesis and astrogenesis are observed in deafferented vestibular nuclei after unilateral vestibular nerve section in adult cats...
  77. ncbi Transtympanic tetrodotoxin alters the VOR and Fos labeling in the vestibular complex
    D W Saxon
    Department of Anatomy and Cell Biology, Indiana University School of Medicine, Evansville Center for Medical Education, 8600 University Blvd, Evansville, IN 47712, USA
    Neuroreport 12:3051-5. 2001
    ..Fos immunocytochemistry, revealed an asymmetric pattern of Fos labeling in the medial, inferior and superior vestibular nuclei and the prepositus hypoglossal nucleus...
  78. pmc Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation
    Martine Liberge
    Universite Aix Marseille, UMR 6149 Université de Provence CNRS, Neurobiologie Intégrative et Adaptative, Pole 3C, Comportement, Cerveau, Cognition, Centre de St Charles, Case B, 3 Place Victor Hugo, 13331 Marseille Cedex 3, France
    J Neuroinflammation 7:91. 2010
    Unilateral vestibular deafferentation results in strong microglial and astroglial activation in the vestibular nuclei (VN) that could be due to an inflammatory response...
  79. ncbi Functional organization of vestibular commissural connections in frog
    David Malinvaud
    Laboratoire de Neurobiologie des Réseaux Sensorimoteur, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7060, Universite Paris 5, Paris Cedex 06, France
    J Neurosci 30:3310-25. 2010
    ....
  80. ncbi Effects of 17beta-estradiol on glutamate synaptic transmission and neuronal excitability in the rat medial vestibular nuclei
    S Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, Perugia, Italy
    Neuroscience 165:1100-14. 2010
    ..These findings provide evidence for a novel potential mechanism to modulate the responsiveness of vestibular neurons to afferent inputs, and so regulate vestibular function in vivo...
  81. ncbi Properties and axonal trajectories of posterior semicircular canal nerve-activated vestibulospinal neurons
    Keisuke Kushiro
    Department of Human and Environmental Studies, Kyoto University, Yoshida nihonmatsu cho, Sakyo ku, Kyoto 606 8501, Japan
    Exp Brain Res 191:257-64. 2008
    ..Selective electrical stimulation was applied to the PC nerve, and extracellular recordings in the vestibular nuclei were performed. The properties of the PC nerve-activated vestibulospinal neurons were then studied...
  82. pmc Plasticity of spontaneous excitatory and inhibitory synaptic activity in morphologically defined vestibular nuclei neurons during early vestibular compensation
    Mei Shao
    Dept of Anatomy and Regenerative Biology, George Washington Univ Medical Center, 2300 I St N W, Washington, DC 20037, USA
    J Neurophysiol 107:29-41. 2012
    ..Principal cells of the chick tangential nucleus offer a subset of morphologically defined vestibular nuclei neurons to study functional changes after vestibular lesions...
  83. pmc Role of the commissural inhibitory system in vestibular compensation in the rat
    Filip Bergquist
    Centre for Integrative Physiology, School of Biomedical Sciences, Edinburgh University College of Medicine and Veterinary Medicine, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    J Physiol 586:4441-52. 2008
    ....
  84. ncbi Stress axis plasticity during vestibular compensation in the adult cat
    B Tighilet
    Universite Aix Marseille, UMR 6149 Université de Provence CNRS, Neurobiologie Intégrative et Adaptative, Pole 3C, Comportement, Cerveau, Cognition, Centre de St Charles, 3 Place Victor Hugo, Marseille Cedex 3, France
    Neuroscience 160:716-30. 2009
    ..AVP) immunoreactivity (Ir) were analyzed and quantified in the paraventricular nucleus (PVN) and the vestibular nuclei (VN) complex of cats killed early (1 and 7 days) or late (30 and 90 days) after UVN...
  85. pmc Different neural strategies for multimodal integration: comparison of two macaque monkey species
    Soroush G Sadeghi
    Department of Physiology, McGill University, 3655 Prom Sir William Osler, Room 1218, Montreal, QC H3G 1Y6, Canada
    Exp Brain Res 195:45-57. 2009
    ..Notably, in rhesus monkey (Macaca mulata), an Old World monkey, neurons in the vestibular nuclei are insensitive to passive stimulation of neck proprioceptors...
  86. ncbi Implications of noise and neural heterogeneity for vestibulo-ocular reflex fidelity
    Timothy M Hospedales
    Institute for Adaptive and Neural Computation, School of Informatics, University of Edinburgh, Edinburgh EH1 2QL, U K
    Neural Comput 20:756-78. 2008
    ....
  87. ncbi Development of action potentials and apamin-sensitive after-potentials in mouse vestibular nucleus neurones
    M B Dutia
    Department of Physiology, Medical School, Edinburgh, UK
    Exp Brain Res 118:148-54. 1998
    ..These data show that the apamin-sensitive I(AHP) is one of the first ionic conductances to appear in type B cells, and that it plays an important role in regulating the intrinsic rhythmicity and excitability of these cells...
  88. pmc Changes in protein expression in the rat medial vestibular nuclei during vestibular compensation
    Janet M Paterson
    Centre for Integrative Physiology, Biomedical Sciences, Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    J Physiol 575:777-88. 2006
    The molecular mechanisms of neural and synaptic plasticity in the vestibular nuclei during 'vestibular compensation', the behavioural recovery that follows deafferentation of one inner ear, are largely unknown...
  89. pmc Self-motion signals in vestibular nuclei neurons projecting to the thalamus in the alert squirrel monkey
    Vladimir Marlinski
    Department of Neurobiology, Barrow Neurological Institute, 350 West Thomas Road, Phoenix, AZ 85013, USA
    J Neurophysiol 101:1730-41. 2009
    Sixty vestibular nuclei neurons antidromically activated by electrical stimulation of the ventroposterior thalamus were recorded in two alert squirrel monkeys...
  90. ncbi Vestibular convergence patterns in vestibular nuclei neurons of alert primates
    J David Dickman
    Department of Research, Central Institute for the Deaf, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurophysiol 88:3518-33. 2002
    ..In the present study, we have examined the responses of primate rostral vestibular nuclei (VN) neurons that do not exhibit any eye movement-related activity using 0...
  91. ncbi Comparison of human ocular torsion patterns during natural and galvanic vestibular stimulation
    Erich Schneider
    Department of Neurology with Center for Sensorimotor Research, Klinikum Grosshadern, Ludwig Maximilians University, 81377 Munich, Germany
    J Neurophysiol 87:2064-73. 2002
    ..Thus we conclude that both the tonic and the phasic OT responses to GVS can be reproduced by pure rotational stimulations and that the OT-related effects of GVS on SCC afferents are similar to natural stimulations at small amplitudes...
  92. ncbi Immunohistochemical localization of calcium-binding proteins in the brainstem vestibular nuclei of the jaundiced Gunn rat
    Wayne T Shaia
    Department of Otolaryngology Head and Neck Surgery, School of Medicine, Medical College of Virginia Campus, Virginia Commonwealth University Health System, Richmond 23298 0599, USA
    Hear Res 173:82-90. 2002
    ..cell death, we hypothesized that altered expression of calcium-binding proteins may occur in brainstem vestibular nuclei of the classic animal model of bilirubin neurotoxicity...
  93. ncbi Primary trigeminal afferents to the vestibular nuclei in the rat: existence of a collateral projection to the vestibulo-cerebellum
    G Pinganaud
    Laboratoire de Neuroanatomie Fonctionnelle des Systèmes Sensorimoteurs, Paris, France
    Neurosci Lett 264:133-6. 1999
    Projections from the mesencephalic trigeminal nucleus to the vestibular nuclei were analyzed using retrograde and anterograde tracing methods...
  94. ncbi Medial vestibular nucleus in the guinea-pig: histaminergic receptors. II. An in vivo study
    T Yabe
    Laboratoire de Physiologie Neurosensorielle, CNRS, Paris, France
    Exp Brain Res 93:249-58. 1993
    ..remained an open question since, during the slicing procedure, any histaminergic axons projecting to the vestibular nuclei would have been interrupted. This rendered our study of H3-mediated effects of histamine difficult...
  95. ncbi Serotonergic and nonserotonergic neurons in the dorsal raphe nucleus send collateralized projections to both the vestibular nuclei and the central amygdaloid nucleus
    A L Halberstadt
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Neuroscience 140:1067-77. 2006
    ..and nonserotonergic neurons in the dorsal raphe nucleus are sources of collateralized axonal projections to vestibular nuclei and the central amygdaloid nucleus in the rat...
  96. ncbi Expression of the AMPA-selective receptor subunits in the vestibular nuclei of the chinchilla
    P Popper
    Division of Head and Neck Surgery, UCLA School of Medicine, Los Angeles, CA 90024 1624, USA
    Brain Res Mol Brain Res 44:21-30. 1997
    ..the central nervous system; however, no detailed description of its distribution is available in the vestibular nuclei. In the present study, in situ hybridization histochemistry and immunohistochemistry were used to localize ..
  97. ncbi Effects of histamine and betahistine on rat medial vestibular nucleus neurones: possible mechanism of action of anti-histaminergic drugs in vertigo and motion sickness
    J J Wang
    Department of Physiology, Medical School, Edinburgh, UK
    Exp Brain Res 105:18-24. 1995
    ....
  98. pmc Histaminergic and glycinergic modulation of GABA release in the vestibular nuclei of normal and labyrinthectomised rats
    Filip Bergquist
    Centre for Integrative Physiology, School of Biomedical Laboratory Sciences, Edinburgh University Hugh Robson Building, George Square, Edinburgh EH8 9XD, UK
    J Physiol 577:857-68. 2006
    ..with increased central histamine release and alterations in histamine H(3) receptor expression in the vestibular nuclei. However, little is known of the effects of histamine on neurotransmission in the vestibular nuclei, and the ..
  99. ncbi Temporal changes of cFos-like protein expression in medial vestibular nuclei following arsanilate-induced unilateral labyrinthectomy in rats
    Min Sun Kim
    Department of Physiology, Wonkwang University School of Medicine and Institute of Wonkwang Medical Science, Iksan 570 749, South Korea
    Neurosci Lett 319:9-12. 2002
    ..two phases of significant asymmetry of cFos-like (cFL) protein expression between the bilateral medial vestibular nuclei, with more expression in the contralateral medial vestibular nuclei to the injured side than in the ..
  100. ncbi Increased noise level of purkinje cell activities minimizes impact of their modulation during sensorimotor control
    F E Hoebeek
    Department of Neuroscience, Erasmus MC, Dr Molenwaterplein 50, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neuron 45:953-65. 2005
    ..This study demonstrates the importance of regularity of firing in Purkinje cells for neuronal information processing...
  101. ncbi Role of nitric oxide in long-term potentiation of the rat medial vestibular nuclei
    S Grassi
    Department of Internal Medicine, Section of Human Physiology, University of Perugia, I 06100 Perugia, Italy
    Neuroscience 101:157-64. 2000
    ..investigated the role of nitric oxide in long-term potentiation induced in the ventral portion of the medial vestibular nuclei by high-frequency stimulation of the primary vestibular afferents...

Research Grants62

  1. VESTIBULO-CEREBELLAR CIRCUITS
    CAREY DAVID BALABAN; Fiscal Year: 2013
    ..tracing methods to test the hypothesis that the caudal parabrachial nucleus projects by collaterals to the vestibular nuclei and the paratrigeminal and caudal spinal trigeminal nuclei...
  2. Chemical Anatomy and Synaptology of Vestibulo-Sympathetic Pathways
    Gay R Holstein; Fiscal Year: 2013
    ..using rats as the experimental model, bilateral sinusoidal galvanic vestibular stimulation to activate the vestibular nuclei, telemetric detection of blood pressure, anterograde and retrograde tract-tracing, and immunofluorescence ..
  3. ROLE OF INHIBITION WITHIN THE CEREBELLAR NODULUS/UVULA IN VESTIBULAR PROCESSING
    TATYANA ALEKSANDROVNA YAKUSHEVA; Fiscal Year: 2012
    ..from the vestibular organs (otoliths and semicircular canals), and send outputs to cerebellar and brainstem vestibular nuclei. The long-term goal of this project is to understand the role of the NU in spatial navigation and vestibular ..
  4. VESTIBULAR REGULATION OF RESPIRATORY MUSCLE ACTIVITY
    Bill J Yates; Fiscal Year: 2013
    ..Specific Aim 2 will employ inactivation of subregions of the vestibular nuclei (VN) to identify the area that is essential for producing vestibular-elicited vomiting...
  5. Neural Interactions Among Multiple Motor Structures
    Marc H Schieber; Fiscal Year: 2010
    ..2, Spatial Interaction of Otolith Mediated Collic Reflexes (Gdowski, PI) asks how interactions between the vestibular nuclei and cervical motoneuron pools stabilize the head during linear whole-body translation...
  6. Mechanisms of Persistent Activity in a Neural Integrator
    David W Tank; Fiscal Year: 2010
    ..The possibility that vestibular nuclei are part of the integrator will be tested using local pharmacological inactivation...
  7. Neural Activity in Guinea Pig Vestibular Nuclei During Volitional Head Movements
    William M King; Fiscal Year: 2013
    ....
  8. NEURAL MECHANISMS OF VESTIBULAR FUNCTION
    Dora Angelaki; Fiscal Year: 2013
    ..In aim 2, we will compare heading direction discrimination thresholds of 2nd-order neurons in the vestibular nuclei with those of otolith afferents...
  9. Vestibular Control of the Vasovagal Response
    Bernard Cohen; Fiscal Year: 2013
    ..In Aim 3, single unit neurophysiological studies in otolith-recipient portions of the caudal vestibular nuclei will identify the functional characteristics and physiological signature of VVR- related neurons...
  10. Vestibulo-spinal influences on reflex performance
    GREG GDOWSKI; Fiscal Year: 2009
    ..To test this hypothesis we will record the firing behavior of VS neurons located in the vestibular nuclei during reflexive, voluntary, and passive head movements in the awake squirrel monkey...
  11. MULTISENSORY INTEGRATION OF VESTIBULAR AND MAGNETIC SIGNALS
    J David Dickman; Fiscal Year: 2013
    ..regions in the brain known to be involved with spatial orientation and navigation tasks, including the vestibular nuclei, dorsal thalamus, hippocampus, and visual association cortex...
  12. RESEARCH AND TRAINING CENTER IN HEARING AND BALANCE
    Eric Young; Fiscal Year: 1999
    ..central auditory system of awake, behaving animals; electrophysiological study of recovery processes in the vestibular nuclei after vestibular nerve section; behavioral study of short-term adaptation of the vestibuloocular reflex in ..
  13. MORPHOPHYSIOLOGICAL ANALYSIS OF VESTIBULAR NEURONS
    ADRIAN PERACHIO; Fiscal Year: 2001
    ..In previous work on this project, we have produced new information on the responses of neurons in the vestibular nuclei that represent spatial and temporal transformation of the sensory signal into appropriate driving signals ..
  14. MOTOR CONTROL--TONIC NECK AND VESTIBULOSPINAL R EFLEXES
    VICTOR WILSON; Fiscal Year: 1992
    ..For vestibulospinal reflexes the goal will be to find relay neurons between vestibular nuclei and motoneurons...
  15. Context-specific spatial adaptation of the VOR
    Sergei B Yakushin; Fiscal Year: 2011
    ..to determine the cellular basis for the gravity and frequency dependent aspects of this adaptation in the vestibular nuclei of the alert monkey...
  16. PROCESSING OF INFORMATION BY THE VESTIBULOSPINAL SYSTEM
    ROBERT SCHOR; Fiscal Year: 1993
    ..of the head movement, (b) how these signals are combined and processed by neurons in the brainstem vestibular nuclei, (c) with information is sent to various spinal motor pools to produce coordinated reflexes (for example, ..
  17. THREE DIMENSIONAL ORGANIZATION OF THE OCULOMOTOR SYSTEM
    Dora Angelaki; Fiscal Year: 1999
    ..from the vestibular labyrinths converge with visual inputs in a region of the brainstem that comprise the vestibular nuclei. Most previous investigations attempting to elucidate the exact role of vestibular nuclei neurons in ..
  18. Neural Control of Head Stabilization and Tracking
    Barry Peterson; Fiscal Year: 2005
    ..into the cervical spinal cord, brainstem reticular formation or regions of cerebral cortex projecting to vestibular nuclei and reticular formation to visualize pathways involved in neck motor control in primates...
  19. VESTIBULAR LABYRINTH IN HEALTH AND DISEASE
    STEPHEN HIGHSTEIN; Fiscal Year: 2000
    ..Concepts of the function of the vestibular nuclei have been completely revised by studies showing that signals related to head motion that are expressed in ..
  20. PHYSIOLOGY & ADAPTIVE CONTROL OF OTOLITH/OCULAR REFLEXES
    Richard Clendaniel; Fiscal Year: 2001
    ..dimensional and vergence eye movements in both monkeys and humans, as well as single-unit activity in the vestibular nuclei of the squirrel monkeys, will be recorded...
  21. SPATIAL ORIENTATION & PLASTICITY IN THE VESTIBULAR SYSTE
    Bernard Cohen; Fiscal Year: 2001
    ..about how information related to the GIA vector is coded and adapted by the vestibulo-cerebellum and vestibular nuclei, what role this coding plays in maintenance of posture and balance during locomotion, and how locomotion and ..
  22. BIOCHEMICAL CORRELATE OF VESTIBULAR FUNCTION
    Ruediger Thalmann; Fiscal Year: 1980
    ..aim is to correlate the generated quantitative histochemical patterns to the somatotopic organization of the vestibular nuclei. In order to provide a precise three-dimensional framework for the mapping of forthcoming histochemical ..
  23. Raphe Nuclei Projections to Vestibular Nuclei
    ADAM HALBERSTADT; Fiscal Year: 2005
    ..Although fibers originating from raphe nuclei are known to innervate the vestibular nuclei, little is known about the specific organization of the raphe-vestibular pathway...
  24. Structure-Function Studies of Avian MVN Neurons
    Adria Gottesman Davis; Fiscal Year: 2009
    ..Like most vertebrate vestibular nuclei, the MVN contains neurons with different morphologies and functions whose responses are analyzed most often ..
  25. Vestibular Contributions to Head Direction Cells
    Joel Brown; Fiscal Year: 2007
    ..The rostral NPH receives input from vestibular nuclei and projects to dorsal tegmental nucleus (DTN), where angular head velocity signals have been found...
  26. SENSING & CONTROLLING MOTION--VESTIBULAR & SENSORIMOTOR
    Bernard Cohen; Fiscal Year: 1991
    ..input to the vestibular system during linear motion, neural processing and transmitters utilized in the vestibular nuclei and cerebellum, including vestibulo-spinal interactions and their relation to central and peripheral ..
  27. NEURAL MECHANISMS OF VESTIBULAR FUNCTION
    STEPHEN HIGHSTEIN; Fiscal Year: 2003
    ..The effects of efferent vestibular nuclei stimulation on hair cell receptor and membrane potentials, and upon transmitter release as measured by ..
  28. ORPHAN NUCLEAR RECEPTOR COUP-TFI IN HEARING AND BALANCE
    Fred Pereira; Fiscal Year: 2000
    ..of COUP-TFI during development and differentiation of inner ear structure and the brainstem auditory and vestibular nuclei. 2...
  29. NEUROCHEMICAL CORRELATES OF VESTIBULAR COMPENSATION
    Glenn Thompson; Fiscal Year: 1991
    ..visualized all of these neurochemicals (except for ACh), using immunocytochemical techniques, in the vestibular nuclei of normal squirrel monkeys; ACh has been indirectly visualized using the histochemical reaction for AChE, ..
  30. Orphan Nuclear Receptor COUP TFI in Hearing and Balance
    Fred Pereira; Fiscal Year: 2005
    ..of COUP-TFI during development and differentiation of inner ear structures and the brainstem auditory and vestibular nuclei. 2...
  31. CENTRAL VESTIBULAR MECHANISMS
    Charles Markham; Fiscal Year: 1980
    ..extracellularly and intracellularly in the reticular formation, abducens nucleus, third nerve nucleus and vestibular nuclei during the course of natural vestibular stimulation or electrical stimulation of the labyrinth...
  32. State-dependent vestibular response and neural processing
    KIMBERLY MCARTHUR; Fiscal Year: 2009
    ..To characterize the effect of simulated flight on neural responses to rotational motion in the brainstem vestibular nuclei. I will compare vestibulospinal responses with the animal at rest and in airflow-evoked flight posture...
  33. Signal processing in the vestibular nuclei
    Michael Rowe; Fiscal Year: 2003
    ....
  34. FUNCTIONAL CORRELATES OF MOLECULAR MARKERS OF ADAPTATION
    Galen Kaufman; Fiscal Year: 2004
    ..We hypothesize that ITFs such as Fos will be expressed in specific vestibular nuclei and cerebellar cortical neurons in response to gain adaptation of the VOR...
  35. ROLE OF PARABRACHIAL NUCLEUS IN VESTIBULAR PROCESSING
    CYRUS MCCANDLESS; Fiscal Year: 2004
    ..Additionally, the vestibular nuclei-PBN-CeA network is not well characterized anatomically...
  36. Sex differences in vestibular effects of magnetic fields
    Angie Cason; Fiscal Year: 2005
    ..At the neural level, MF exposure induced c-Fos in brainstem visceral and vestibular nuclei. These effects are similar to the effects of vestibular disturbance, such as rotation...
  37. CONFERENCE ON OCULOMOTOR AND VESTIBULAR PHYSIOLOGY
    Bernard Cohen; Fiscal Year: 1980
    ..includes studies of how pathways within the CNS are utilized for oculomotor processing, studies of how the vestibular nuclei are controlled by the visual and body postural systems and studies of vestibulo-vestibular interactions...
  38. SYNAPTIC TRANSMISSION DURING NEURONAL DIFFERENTIATION
    Kenna D Peusner; Fiscal Year: 2010
    ..b>Vestibular nuclei neurons must be intact for recovery, suggesting that adaptation involves these neurons...
  39. Methylphenidate & gene expression in the rat brain.
    JOAN BAIZER; Fiscal Year: 2004
    ..abstract_text> ..
  40. DEVELOPMENT OF VESTIBULAR NUCLEI NEURONS
    KENNA PEUSNER; Fiscal Year: 2005
    ..include: (1) Describe the pathways, distribution, and terminals formed by otolithic afferents in the chick vestibular nuclei and their relationship to ampullary nerve inputs in hatchlings; (2) Study the onset and emergence of action ..
  41. RECOVERY OF DAMAGE TO THE VESTIBULAR-AUDITORY SYSTEM
    NEAL BARMACK; Fiscal Year: 2003
    ..abstract_text> ..
  42. NEURONAL PLASTICITY AND THE CONTROL OF EYE POSITION
    NEAL BARMACK; Fiscal Year: 2005
    ..We will use "differential display" to identify mRNAs in dorsal cap neurons whose proteins might be responsible for two functions: 1) Axonal transport of CRF , and 2) Calcium binding. ..
  43. Vestibular Influences on Head Direction Cell Activity
    Bill Yates; Fiscal Year: 2004
    ..One purpose of the proposed research is to establish whether a relatively direct pathway links the vestibular nuclei with brain areas containing HDC...
  44. Central Neuronal Activity in Vestibular Compensation
    SHAWN NEWLANDS; Fiscal Year: 2009
    ..movement will be investigated using extracellular single unit recordings from the rostral bilateral vestibular nuclei both before and after peripheral vestibular lesion...
  45. Physiology of vestibulo-thalamic pathways
    Robert McCrea; Fiscal Year: 2005
    DESCRIPIION(provided by applicant)Sensory vestibular signals are transformed in the vestibular nuclei aboutn a vartety of ways. The nature of transformation depends on the type of vestibular nucleus neuron and the behavioral context...
  46. PHYSIOLOGY OF OCULOMOTOR PREMOTOR PATHWAYS
    Robert McCrea; Fiscal Year: 2007
    The aim of the proposed studies is to study the firing behavior of afferent inputs to the vestibular nuclei that are influential in modifying signal processing in vestibulo-ocular reflex (VOR) pathways during smooth tracking head ..
  47. MORPHOLOGIC BASIS FOR CENTRAL VESTIBULAR INHIBITION
    GAY HOLSTEIN; Fiscal Year: 2002
    ..The objective of this current research proposal is to visualize glycinergic neurons and terminals in the vestibular nuclei, in order to further elucidate the cellular bases for inhibitory control of the velocity storage component ..
  48. VESTIBULAR AFFERENT ACTIVITY AFTER CANAL PLUGGING
    Sergei Yakushin; Fiscal Year: 2002
    ..This work should lead to a clearer understanding of how lesions, such as plugging and nerve section, affect the sensory processing of head movements and how the central vestibular system adapts to these types of lesions. ..
  49. Adaptation of Spatial Orientation in Locomotion and Posture
    FAY BAHLING HORAK; Fiscal Year: 2010
    ..abstract_text> ..
  50. VESTIBULAR NUCLEUS ACTIVITY IN VESTIBULAR COMPENSATION
    SHAWN NEWLANDS; Fiscal Year: 2003
    ..Single-unit recordings of neurons in the vestibular nuclei will be analyzed for changes in their oculomotor and angular acceleration sensitivity before unilateral ..
  51. Behavioral and Neural Effects of High Magnetic Fields
    THOMAS HOUPT; Fiscal Year: 2009
    ..c-Fos was observed in visceral and stress relays and in vestibular nuclei (e.g. the medial vestibular nucleus)...
  52. PERIPHERAL AND CENTRAL POSTURAL DISORDERS IN THE ELDERLY
    Fay Horak; Fiscal Year: 2003
    ..abstract_text> ..
  53. MOLECULAR MECHANISMS OF CONDITIONED TASTE AVERSION
    THOMAS HOUPT; Fiscal Year: 2004
    ..These experiments will contribute to an understanding of the neural pathways and molecular mechanisms underlying changes in food preferences that occur in eating disorders such as obesity and anorexia nervosa. ..
  54. Vestibular Compensation During Volitional Head Movements
    SHAWN NEWLANDS; Fiscal Year: 2004
    ..Single-unit recordings of neurons in the vestibular nuclei are underway to analyze changes in their oculomotor and passive angular acceleration sensitivity before ..
  55. Chemoanatomic bases for peripheral vestibular function
    GAY HOLSTEIN; Fiscal Year: 2007
    ..The proposed research is unique, and will have direct bearing on the development of more effective therapeutic interventions, both medicinal and device-oriented, for peripheral vestibular disorders. [unreadable] [unreadable] [unreadable]..
  56. EFFECTS OF DBS ON POSTURE AND OROMOTOR CONTROL
    Fay Horak; Fiscal Year: 2005
    ..Quantifying two types of postural and oromotor control in the same subjects will also substantially increase our understanding of the role of the basal ganglia in axial motor control. ..